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FIBROMA OVARII

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Clinical Features

Fibroma Ovarii is a tumor arising in the

ovarian stroma that are composed of

fibroblasts.

90 % unilateral.

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Macrocopic

Fibroma ovarii is a solid tumor, spherical

or slightly lobulated, encapsulated, hard,

gray-white in color.

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FIBROMA OVARY

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Microscopic

Fibroma ovarii are composed of well

differentiated fibroblast, which have

spindle nuclei, collagenous connective

tissue interspersed between them.

The fibroblast cells are arranged in

irregular bundles (nonspesific pattern)

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LIPOMA

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Clinical Features

Lipoma is benign tumor of fat.

The most common soft tissue tumor ofadulthood.

Most lipomas are subcutaneous masses, welldemarcated, soft, mobile, and painless tumor.However, lipoma can also occur in the deep-seated tissue (intramuscular lipoma).

Location: can arise in any location but themajority occur in the upper half of the body,particularly the trunk and neck.

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Macroscopic & Microscopic

Lipomas can grow to a large size

Macroscopic:

usually encapsulated.

Cut section: solid tumor, consisted of bright

yellow fat tissue.

Microscopic:

Lipomas are composed of mature adipose

tissue with no cellular atypia ( no sign of

anaplasia).

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FIBROSARCOMA

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Clinical Features

Fibrosarcoma is malignant tumor originatingfrom fibroblast cells.

Age: commonly occur in adult, but can occur in

any age group. They arise from superficial and deep connective

tissue such as fascia, tendon, periosteum, etc.

Location: may occur anywhere in the body, most

commonly in the retroperitoneum, thigh, knee,and distal extremities.

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Macrocopic

Typically, these neoplasm are:

Unencapsulated

Infiltrative

Soft, fish-flesh consistency

Often having areas of hemorrhage and

necrosis.

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FIBROSARKOMA

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Microscopic

Tumor composed of fibroblast cells whichhave plump-spindle nuclei with sign ofanaplasia.

These cells are arranged in fascicles thatintersect each other at acute anglesresulting in a herringbone appearance.

Numerous mitotic activity. May contain areas of hemorrhage and

necrosis

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LEIOMYOMA UTERI

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Clinical Features Leiomyoma is benign tumor of smooth muscles

Uterine leiomyoma are perhaps the mostcommon benign tumor in females. These benigntumor may present in about 75% of females of

reproductive age. Leiomyoma of the uterus may be asymptomatic.

The most important symptoms are abnormalbleeding, urinary frequency (due to compression

of the bladder), impaired fertility, abdominalmass (if the tumor has already extensive).

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Macroscopic

Leimyomas are solid and sharply circumscribed

tumor, round, firm, gray-white in color, varying in

size from small nodule to massive tumor.

Cut section: whorled pattern of smooth musclebundles.

They can occur :

Within the myometrium---intramural

Just beneath the endometrium--- submucosal

Beneath the serosa --- subserosal

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Microscopic

Leiomyoma is composed of proliferation of

smooth muscle cells, which have oval and

long (spindle) nuclei, uniform in size and

shape (no sign of anaplasia), andarranged in characteristic whorled pattern

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