Dott.ssa Giulia De Falco - Pubblicazioni

1. M.R. Ruocco, X. Chen, C. Ambrosino, E. Dragonetti, W. Liu, M. Mallardo, G. De Falco, G. Franzoso, I. Quinto, S. Venuta and G. Scala. Regulation of HIV-1 Long Terminal Repeat by interaction of C/EBP (NF-IL6) and NF-kB/Rel Transcription Factors” - (1996) J Biol Chem 271:22479-22486. 2. V.Giordano, G. De Falco, C. Ambrosino, M.R. Ruocco, I. Quinto, P.G. Pelicci, P. Del Mastro and G. Scala. Interleuchin-6 induces the association of SHC with gp130 and Jak2 through different tyrosine-binding domains. (1997) J Immunology 158:4097-5103. 3. G. De Falco and A. Giordano. CDK9 (PITALRE): a multifunctional cdc2-related kinase. (1998) J Cell Physiol, 177:501-506. 4. Romano G., Kasten M., De Falco G., Micheli P. Khalili K. and Giordano A. Regulatory functions of Cdk9 and of cyclin T1 in HIV Tat transactivation pathway gene expression. (1999) J Cell Biochem, 75:357-368. 5. G. De Falco, L. Bagella, P.P Claudio, A. De Luca, Y. Fu, B. Calabretta, A. Sala and A. Giordano: Physical interaction between CDK9 and B-Myb results in suppression of B-Myb gene autoregulation. (2000) Oncogene, 19:373-379. 6. Zini N., Trimarchi C., Claudio P.P., Stiegler P., Marinelli F., Maltarello M.C., La Sala D., De Falco G., Russo G., Ammirati G., Maraldi N.M., Giordano A. and Cinti C. pRb2/p130 and p107 control cell growth by multiple strategies and in association with different compartments within the nucleus. (2001) J Cell Physiol, 189:34-44. 7. De Falco M, Laforgia V, Fedele V, De Luca L, Cottone G, De Falco G and De Luca A. Vasoactive intestinal peptide stimulation modulates the expression of Bcl-2 family members in the adrenal gland of the lizard Podarcis sicula. (2001) Histochem J, 33:639-45. 8. Bellan C., De Falco G., Tosi G.M., Lazzi S., Ferrari F., Morbini G., Bartolommei S., Toti P., Mangiavacchi P., Cevenini G., Trimarchi C., Cinti C., Giordano A., Leoncini L., Tosi P. and Cottier H. Missing expression of pRb2/p130 in human retinoblastomas is associated with reduced apoptosis and lesser differentiation. (2002)Invest Ophthalmol Vis Sci. 43:3602-8. 9. De Falco G. and Giordano A. CDK9: from basal transcription to cancer and AIDS. (2002) Cancer Biol Ther 1:342-7. 10. Lazzi S., Bellan C., De Falco G., Cinti C., Ferrari F., Nyongo A., Claudio P.P., Tosi G.M., Vatti R., Gloghini A., Carbone A., Giordano A., Leoncini L. and Tosi P. Expression of RB2/p130 tumor-suppressor gene in AIDS-related non-Hodgkin's lymphomas: implications for disease pathogenesis. (2002) Hum Pathol 33:723-31. 11. Simone C., Stiegler P., Bagella L., Pucci B., Bellan C., De Falco G., De Luca A., Guanti G., Puri P.L. and Giordano A. Activation of MyoD-dependent transcription by cdk9/cyclin T2. (2002) Oncogene 21:4137-48. 12. De Falco G., Neri L.M., De Falco M., Bellan C., Yu Z., De Luca A., Leoncini L. and Giordano A. Cdk9, a member of the cdc2-like family of kinases, binds to gp130, the receptor of the IL-6 family of cytokines. (2002) Oncogene. 21:7464-70. 13. Bellan C., Lazzi S., De Falco G., Nyongo A., Giordano A., Leoncini L. Burkitt's lymphoma: new insights into molecular pathogenesis. (2003) J Clin Pathol. 56:188-92. 14. De Falco, G., Bellan, C., Lazzi, S., Claudio, P.P., La Sala, D., Cinti, C., Tosi, P., Giordano, A. and Leoncini L. Interaction between HIV-1 Tat and pRb2/p130: a possible mechanism in the pathogenesis of AIDS-related neoplasms. (2003) Oncogene. 22:6214-9. 15. Bellan C., De Falco G., Lazzi S. and Leoncini L., Pathogenetic aspects of AIDS-related malignancies. (2003) Oncogene 22:6639-45. 16. Bellan C., De Falco G., Lazzi S., Schuerfeld K., Micheli P., Bartolommei S., Vestri M., Nyongo A., Pileri S., Leoncini L., Tosi P. and Giordano A. Cdk9/Cyclin T expression in reactive lymph nodes and malignant lymphomas. (2004) The Journal of Pathol 203:946-952.

17. De Falco G., Bellan C., D’Amuri A., Angeloni G., Giordano A. and Leoncini L.: Cdk9 regulates neural differentiation and its expression correlates with the differentiation grade of PNET tumors. (2005) Cancer Biol Therapy 4:277-81. 18. Florio P, Torricelli M, Galleri L, De Falco G, Leucci E, Calonaci G, Picciolini E, Ambrosini G, Linton EA, Petraglia F. High fetal urocortin levels at term and preterm labor. (2005) J Clin Endocrinol Metab. 90:5361-5. 19. P. Vogiatzi and G. De Falco: Commentary: Gene expression profiles of serous, endometrioid, and clear cell subtypes of ovarian and endometrial cancer. Zorn KK, Bonome T, Gangi L, Chandramouli GV, Awtrey CS, Gardner GJ, Barrett JC,Boyd J, Birrer MJ. Clin Cancer Res 2005; 11:6422-30. (2005) The Women’s Oncology Review, 5:219 – 221. 20. Vogiatzi P, De Falco G, Claudio PP, Giordano A. How Does the Human RUNX3 Gene Induce Apoptosis in Gastric Cancer? Latest Data, Reflections and Reactions. (2006) Cancer Biol Ther. 5: 371-4. 21. Florio P, De Falco G, Leucci E, Torricelli M, Torres PB, Toti P, Dell’Anna A, Santopietro R, Pecciarini L, Leoncini L and Petraglia F: Urocortin expression is downregulated in human endometrial carcinoma. (2006) J Endocrinol. 190:99-105. 22. Florio P, Torricelli M, De Falco G, Leucci E, Giovannelli A, Gazzolo D, Severi FM, Bagnoli F, Leoncini L, Linton EA, Petraglia F. High maternal and fetal plasma urocortin levels in pregnancies complicated by hypertension. (2006) J Hypertens. 24:1831-1840. 23. G De Falco and A Giordano. pRb2/p130: a new candidate in retinoblastoma tumor formation. (2006) Oncogene, 25:5333-40. 24. G. De Falco, F. Comes and C. Simone: pRb master of differentiation: Coupling irreversible cell cycle withdraw to induction of muscle-specific transcription. (2006) Oncogene, 25:5244-9. 25. Leoncini L, Bellan C and De Falco G.: Retinoblastoma gene family expression in lymphoid tissues. (2006) Oncogene, 25:5309-14. 26. Caracciolo V, Reiss K, Khalili K, De Falco G and Giordano A.: Role of the interaction between large T antigen and Rb family members in the oncogenicity of JC virus. (2006) Oncogene, 25:5294-301. 27. Nyagol J, Leucci E, Onnis A, De Falco G, Tigli C, Sanseverino F, Torriccelli M, Palummo N, Pacenti L, Santopietro R, Spina D, Gichangi P, Muchiri L, Lazzi S, Petraglia F, Leoncini L, Giordano A. The Effects of HIV-1 Tat Protein on Cell Cycle during Cervical Carcinogenesis (2006) Cancer Biol Ther, 5:684-90. 28. Roviello F, Corso G, Pedrazzani C, Marrelli D, De Falco G, Berardi A, Garosi L, Suriano G, Vindigni C, De Stefano A, Leoncini L, Seruca R, Pinto E. Hereditary diffuse gastric cancer and E-cadherin: Description of the first germline mutation in an Italian family (2007) Eur J Surg Oncol, 33:448-51. 29. Torricelli M, De Falco G, Florio P, Rossi M, Leucci E, Viganò P, Leoncini L, Petraglia F: Secretory endometrium highly expresses urocortin mRNA and peptide: possible role in the decidualization process. (2007) Hum Reprod, 22:92-96. 30. Eleonora Leucci, Anna Onnis, Giulia De Falco, Anna Luzzi, Giovanna Cerino, Antonio Giordano and Lorenzo Leoncini. Silencing human Rb2/p130 with shRNA. (2007) Cellular Oncology 29:265-8. 31. Eleonora Leucci, Giulia De Falco, Anna Onnis, Giovanna Cerino, Mario Cocco, Anna Luzzi, Domenica Crupi, Chiara Tigli, Cristiana Bellan, Piero Tosi, Lorenzo Leoncini and Antonio Giordano. The role of the Cdk9/Cyclin T1 complex in T cell differentiation. (2007) J Cell Physiol, 212:411-5. 32. Michela Torricelli, Alessia Giovannelli, Eleonora Leucci, Giulia De Falco, Fernando M. Reis, Alberto Imperatore, Pasquale Florio and Felice Petraglia. Labor (term and preterm) is associated with changes in the placental mRNA expression of CRF. (2007) Reprod Sci. 14:241-5.

33. Michela Torricelli, Alessia Giovannelli, Eleonora Leucci, Pasquale Florio, Giulia De Falco, Paulo B. Torres, Fernando Reis, Lorenzo Leoncini and Felice Petraglia. Placental Neurokinin B mRNA expression increases at preterm labor. Placenta, (2007) 28:1020-3. 34. G. De Falco, E. Leucci, D. Lenze, P.P. Piccaluga, P.P. Claudio, A. Onnis, G. Cerino, J. Nyagol, W. Mwanda, C. Bellan, M. Hummel, S. Pileri, P. Tosi, H. Stein, A. Giordano and L. Leoncini: Gene expression analysis identifies novel RBL2/p130 target genes in endemic Burkitt’s lymphoma cell lines and primary tumors. Blood, (2007) 110:1301-7. 35. Bardelli M, Leucci E, Schurfeld K, Bellan C, Passiatore G, Rocchigiani M, Bartolommei S, Orlandini M, Zagursky J, Lazzi S, De Falco G, Tosi P, Oliviero S, Leoncini L. VEGF-D is expressed in activated lymphoid cells and in tumors of hematopoietic and lymphoid tissues. Leukemia & Lymphoma (2007) 48:2014-21. 36. Roviello F, Corso G, Pedrazzani C, Marrelli D, De Falco G, Berardi A, Garosi L, Suriano G, Vindigni C, De Stefano A, Leoncini L, Seruca R, Pinto E. Family history of gastric cancer in a high incidente Italian area. Oncology (2007) 72:243-7. 37. G. De Falco, E. Leucci, A. Onnis, C. Tigli, S. Wirths, M. Cocco, C. Bellan, A. De Luca, A. Lanzavecchia, A. Giordano and L. Leoncini. Cdk9/Cyclin T1 expression during normal lymphoid differentiation and malignant transformation. J Cell Physiol (2008) 215:276-82. 38. C. Giacinti, A. Musarò, G. De Falco, I. Jourdane, L. Bagella, M. Molinaro, C. Simone and A. Giordano. Cdk9-55: a new player in muscle regeneration. J Cell Physiol (2008) 216:576-82. 39. Leucci E, Cocco M, Onnis A, De Falco G, van Cleef P, Bellan C, van Rijk A, Nyagol J, Byakika B, Lazzi S, Tosi P, van Krieken H, Leoncini L. MYC-negative classical Burkitt Lymphoma cases: an alternative pathogenetic mechanism involving miRNA deregulation. J Pathol (2008) 216:440-50. 40. Nyagol J., De Falco G., Palummo N., Shaheen S., Bellan C., Lazzi S., Spina D., Leoncini L. HIV-1 Tat increases micro vessels density independently of VEGF expression in AIDS-related Diffuse Large B-Cell and Burkitt lymphomas. J Hematopathology (2008),1:3-10. 41. Stefano Lazzi, Cristiana Bellan, Anna Onnis, Giulia De Falco, Shaheen Sayed, Ioannis Kostopoulos, Monica Onorati, Alessandro D’Amuri, Rosa Santopietro,Carla Vindigni, Alberto Fabbri, Piero Tosi and Lorenzo Leoncini. Rare Lymphoid Neoplasms Co-expressing B and T-cell Antigens. The Role of Pax-5 Gene Methylation in their Pathogenesis. Hum Pathol (2009), 40:1252-61. 42. Giulia De Falco, Giuseppina Antonicelli, Anna Onnis, Cristiana Bellan, Stefano Lazzi and Lorenzo Leoncini. Role of EBV in microRNA dysregulation in Burkitt lymphoma. Seminars in Cancer Biology 2009, 19:401-6. 43. Leucci E, Onnis A, Cocco M, De Falco G, Costanzo V, Bellan C, Lazzi S and Leoncini L. Altered hsa-miR-127 expression impairs terminal B cell differentiation in EBV-positive Burkitt lymphoma. Int J Cancer (2010), 126:1316-26. 44. Alessandro Carugi, Anna Onnis, Giuseppina Antonicelli, Benedetta Rossi, Susanna Mannucci, Anna Luzzi, Stefano Lazzi, Cristiana Bellan, Gian Marco Tosi, Giulia De Falco and Lorenzo Leoncini. Geographic variation and environmental conditions as cofactors in Chlamydia psittaci association with ocular adnexal lymphomas: a comparison between Italian and African samples. Hematological Oncology (2010), 28:20-6. 45. Paola Indovina, Antonio Acquaviva, Giulia De Falco, Francesca Giorgi, Anna Luzzi, Anna Onnis, Paolo Toti, Alessandro Carugi and Antonio Giordano. Down-regulation and aberrant promoter methylation of p16INK4a: a possible novel heritable susceptibility marker to retinoblastoma. J of Cell Physiol (2010), 223:143-50. 46. Nagaja Capitani, Orso Maria Lucherini, Elisa Sozzi, Micol Ferro, Nico Giommoni, Francesca Finetti, Giulia De Falco, Emanuele Cencini, Pier Giuseppe Pelicci, Francesco Lauria, Francesco Forconi, Cosima T. Baldari. Impaired expression of p66Shc, a novel regulator of B-cell survival, in chronic lymphocytic leukemia. Blood (2010), 115:3726-36.

47. Anna Onnis, Giulia De Falco, Giuseppina Antonicelli, Monica Onorati, Benedetta Rossi, Cristiana Bellan, Joshua Nyagol, Bessie Byakika and Lorenzo Leoncini. microRNA altered expression as an alternative mechanism of MYC dysregulation in aggressive B-cell lymphoma. PloS ONE (2010), 5:piie12960. 48. E. Rogena, S. Lazzi, G. De Falco, M. R. Ambrosio, M. Onorati, B. J. Rocca, C. Bellan, PP. Piccaluga, P.Pileri and L. Leoncini. Burkitt lymphoma, fifty years plus: the beginning and the future. Pathologica, (2010), 102:187-188. 49. Cristiana Bellan, Stefano Lazzi, Giulia De Falco, Emily A. Rogena and Lorenzo Leoncini. Burkitt lymphoma versus diffuse large B-cell lymphoma: a practical approach. Hematological Oncology (2010), 28:53-56. 50. Emily Rogena, Giulia De Falco and Lorenzo Leoncini. A review of the trends in lymphomas: from north to south of the equator. Hematol Oncol (2011), 29:111-115. 51. Pier Paolo Piccaluga, Giulia De Falco, Manjunath Kustagi, Anna Gazzola, Annalisa Astolfi, Anna Onnis, Eleonora Leucci, Maria Rosaria Sapienza, Valeria Calbi, Michael Mawanda, Lynnette Tumwine, Claudio Agostinelli, Cristiana Bellan, Stefano Lazzi, Claudio Tripodo, Martin Ogwang, Andrea Califano, Riccardo Dalla Favera, Stefano A Pileri and Lorenzo Leoncini. Gene expression analysis uncovers similarity and differences in endemic and sporadic Burkitt lymphomas molecular profiles. Blood (2011), 117:3596-608. 52. Giulia De Falco, Emily Rogena and Lorenzo Leoncini: Infectious agents and lymphoma. Seminars in Diagnostic Pathology (2011), 28:178-187. 53. Dido Lenze, Lorenzo Leoncini, Michael Hummel, Stefano Volinia, Chang Gong Liu, Teresa Amato, Giulia De Falco, Jessie Githanga, Heike Horn, Joshua Nyagol, German Ott, Jeff Pallatini, Michael Pfreundschuh, Emily Rogena, Andreas Rosenwald, Reiner Siebert, Carlo M Croce, Harald Stein. The different epidemiologic subtypes of Burkitt Lymphoma share a largely homogenous micro RNA profile distinct from diffuse large B-cell lymphoma. Leukemia (2011), 25:1869-1876. 54. Martina Cozzi, Francesca Giorgi, Eleonora Marcelli, Francesca Pentimalli, Iris Maria Forte, Silvia Schenone, Vittorio D’Urso, Giulia De Falco, Maurizio Botta, Antonio Giordano and Paola Indovina. Antitumor activity of new pyrazolo[3,4-d]pyrimidine SRC kinase inhibitors in Burkitt lymphoma cell lines and its enhancement by WEE1 inhibition. Cell Cycle (in press). 55. Michela Torricelli, Romina Novembri, Nathalie Conti, Giulia De Falco, Maria De Bonis, Felice Petraglia. Correlation with placental Kisspeptin in post term pregnancy and apoptosis. Reproductive Sciences (in press). 56. Susanna Mannucci, Anna Luzzi, Alessandro Carugi, Alessandro Gozzetti, Valeria Malagnino, Lorenzo Leoncini, Cornelia van den Bosch and Giulia De Falco. Euphorbia tirucalli as a possible cofactor in inducing EBV-driven malignant transformation. Advances in Heamatology, (in press). 57. Ambrosio MR, Rocca BJ, Giulia De Falco, Pier Paolo Piccaluga, Onorati M, Ogwang M, Calbi V, Naresh KN, Doglioni C, Leoncini L, Lazzi S. Adipophilin, a novel marker useful in the diagnosis of Burkitt lymphoma. PlosONE (in press). 58. Anna Onnis, Mohsen Navari, Giuseppina Antonicelli, Federica Morettini, Susanna Mannucci, Giulia De Falco, Elena Vigorito and Lorenzo Leoncini. Epstein-Barr Nuclear Antigen-1 induces the expression of the cellular microRNA hsa-miR-127 and B-cell differentiation impairment of EBV-infected memory B cells. New insights in the pathogenesis of Burkitt Lymphoma. Blood Cancer Journal (In press). 59. Maria Teresa Savino, Cristina Ulivieri, Giacomo Emmi, Domenico Prisco, Giulia De Falco, Barbara Ortensi, Enrico Beccastrini, Lorenzo Emmi, Giuliana Pelicci, Mario Milco D'Elios, Cosima T. Baldari The Shc family protein adaptor, Rai, acts as a negative regulator of mouse Th17 cell development. Journal of Leukocyte Biology (in press).

60. A. Onnis, G. De Falco, E. Rogena, F. Morettini, C. Bellan, L. Leoncini. MicroRNA expression profile identifies a different signature between MYC translocation-positive and negative Burkitt Lymphoma cases. (Submitted to the Journal of Pathology). 61. Anna Luzzi, Federica Morettini, Anna Onnis, Cristiana Bellan and Lorenzo Leoncini and Giulia De Falco. microRNA modulation in HIV-associated malignancies. (Submitted). CAPITOLI DI LIBRI 1. Giulia De Falco, Catherine Soprano and Antonio Giordano. Chapter I: Cdk inhibitors: Background and introduction. Cell cycle inhibitors in cancer therapy. Humana press. 2. Antonio Giordano, Giulia De Falco, Emanuel Rubin, Raphael Rubin. Chapter VI: Neoplasia. Rubin’s Pathology (Edition 2007). Lippincott Williams & Wilkins. 3. Giulia De Falco, Donatella Cirillo, Annamaria Rachiglio, Antonio Giordano: I microRNA nella diagnostica molecolare. (2008). 4° Volume Educazionale GOIM. 4. Giulia De Falco, Cristiana Bellan, Stefano Lazzi and Lorenzo Leoncini. Chapter 17: HIV-related lymphoma. In Viral Oncology: Basic Science and Clinical Applications, Ed. Khalili and Jeang KT. John Wiley & Sons (2010). 5. Giulia De Falco, Emily A. Rogena, Kikkeri Naresh, Martine Raphael, Ian Magrath and Lorenzo Leoncini. Managing lymphomas in the African settings: Improving diagnostic accuracy and carrying out research projects. INCTR Book. 6. Giulia De Falco and Alessandro Davide Videtta: “Clinical criterion to define familial gastric cancer” in Springer familial gastric cancer, Springer (in press). 7. Giulia De Falco and Cornelia A. Van den Bosch: “Infectious agents and lymphomas”, in Aggressive B-celll lymphomas: from molecular biology to target therapy, Research Signpost (in press).