Risperidone
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Reactions 1462, p29 - 27 Jul 2013 S Risperidone Priapism: case report A 21-year-old man with autism developed priapism while receiving treatment with risperidone. The man had been diagnosed with an autistic disorder at 38 months of age, and he had been receiving risperidone since the age of 10 years. Between 2002 and 2009 he received risperidone 6 mg/day [route not stated]. In late 2009, his dosage was reduced to 3 mg/day. In August 2011, he experienced an episode of priapism for the first time. The man’s risperidone dosage was reduced to 1.5mg qpm; however, he experienced a recurrence of priapism approximately 6 months later. His dosage was reduced to 1mg at night, but he experienced another priapism episode 1 week later. He was then switched from the generic form of risperidone to the brand form, still at 1mg daily. Ketoconazole was also added to his medications. He experienced two more episodes of priapism. Risperidone was reduced to 0.5mg but he experienced a further episode and, in July 2012, risperidone was discontinued. Over the period of one year, he had experienced five episodes of priapism that had required intervention. However, investigations showed that no permanent tissue damage had occurred, and he was not impotent. In August 2012, ketoconazole was discontinued and leuprorelin was started. Leuprorelin was discontinued in October 2012 and, at 4 months’ follow-up, no further episodes of priapism were noted. Author comment: "[T]his case report illustrates the risk of priapism caused by risperidone for individuals with autism." Pradhan T, et al. Priapism associated with risperidone in a 21-year-old male with autism. Journal of Child and Adolescent Psychopharmacology 23: 367-368, No. 5, Jun 2013. Available from: URL: http://dx.doi.org/10.1089/cap.2013.0022 - USA 803090247 1 Reactions 27 Jul 2013 No. 1462 0114-9954/13/1462-0001/$14.95 Adis © 2013 Springer International Publishing AG. All rights reserved
Transcript of Risperidone
Reactions 1462, p29 - 27 Jul 2013
SRisperidone
Priapism: case reportA 21-year-old man with autism developed priapism while
receiving treatment with risperidone.The man had been diagnosed with an autistic disorder at
38 months of age, and he had been receiving risperidone sincethe age of 10 years. Between 2002 and 2009 he receivedrisperidone 6 mg/day [route not stated]. In late 2009, hisdosage was reduced to 3 mg/day. In August 2011, heexperienced an episode of priapism for the first time.
The man’s risperidone dosage was reduced to 1.5mg qpm;however, he experienced a recurrence of priapismapproximately 6 months later. His dosage was reduced to 1mgat night, but he experienced another priapism episode 1 weeklater. He was then switched from the generic form ofrisperidone to the brand form, still at 1mg daily. Ketoconazolewas also added to his medications. He experienced two moreepisodes of priapism. Risperidone was reduced to 0.5mg buthe experienced a further episode and, in July 2012, risperidonewas discontinued. Over the period of one year, he hadexperienced five episodes of priapism that had requiredintervention. However, investigations showed that nopermanent tissue damage had occurred, and he was notimpotent. In August 2012, ketoconazole was discontinued andleuprorelin was started. Leuprorelin was discontinued inOctober 2012 and, at 4 months’ follow-up, no furtherepisodes of priapism were noted.
Author comment: "[T]his case report illustrates the risk ofpriapism caused by risperidone for individuals with autism."Pradhan T, et al. Priapism associated with risperidone in a 21-year-old male withautism. Journal of Child and Adolescent Psychopharmacology 23: 367-368, No. 5,Jun 2013. Available from: URL: http://dx.doi.org/10.1089/cap.2013.0022 -USA 803090247
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Reactions 27 Jul 2013 No. 14620114-9954/13/1462-0001/$14.95 Adis © 2013 Springer International Publishing AG. All rights reserved
