Neoplasie e Fattori Di Rischio

8/18/2019 Neoplasie e Fattori Di Rischio

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MGC\DBPIG G EBZZCVI JI VIP@OIC 8

WM’IMJBKIMG PZBZIPZI@B

@crsc8 \rcfbfiditiì g stbtisti`b

B.B. 6


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PCNNBVIC

IMZVCJWXICMG…………………………………………………...0JBZBPGZ ………………………………………………………………………...0

ZWNCVG BD @CDCM VGZZC GJ CFGPIZB’……………………..:

WM \C’ JI KVBEI@I…………………………………………………………….:

@CMEVCMZC @BWPB-GEEGZZC @CM KVBEI@C B DIMGG………………..7

ZBFGDDB JGI JBZI………………………………………………………………5

VGKVGPPICMG DIMGBVG G BMBDIPI JGI VGPIJWI…………………………….;

ZGPZ JI ACDNCKCVCU-PNIVMCEE…………………………………………9

ZWNCVG BDDB \VCPZBZB GJ GZMIB JI \VCUGMIGMXB……22

WM \C’ JI KVBEI@I…………………………………………………………..22

@CMEVCMZC @BWPB-GEEGZZC @CM KVBEI@C B DIMGG………………22

ZBFGDDB JGI JBZI……………………………………………………………..20

VGKVGPPICMG DIMGBVG………………………………………………………2:

ZGPZ @OI RWBJVBZC JI IMJI\GMJGMXB………………………………….2:

ZWNCVG BI \CDNCMI G EWNC……………………………….25

WM \C’ JI KVBEI@I…………………………………………………………..25

@CMEVCMZC @BWPB-GEEGZZC @CM KVBEI@C B DIMGG………………2?

@VGBXICMG JI WM NCJGDDC FIUBVIBZC………………………………..2?

ZBFGDDB JGI JBZI……………………………………………………………..29

VGKVGPPICMG DIMGBVG FIUBVIBZB………………………………………...6<

VGKVGPPICMG DIMGBVG WMIUBVIBZB G BMBDIPI JGI VGPIJWI…………..66

ZGPZ JI POB\IVC [IDA………………………………………………………..67

IMZGVUBDDC JI \VGJIXICMG \GV DB VIP\CPZB EWZWVB………………...6;

@CM@DWPICMG………………………………………………….6?


3/28

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IMZVCJWXICMG

Mgdd’bnfitc jgd prckgttc dgkbtc bd `crsc ji \rcfbfiditì g Ptbtisti`b jgdd’B.B. 6


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ZWNCVG BD @CDCM VGZZC GJ CFGPIZB’

Dc s`cpc ji qugstb sgzicmg ï imjbkbrg su qubmtc im`ijb d’cfgsitì sud ris`oic ji `cmtrbrrg um

tuncrg bd `cdcm rgttc. Pi `cmsijgrb cfgsc um ucnc qubmjc id suc FNI (Fcjy Nbss Imjgx,

rbppcrtc pgsc/bdtgzzb) ï nbkkicrg ji 00


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Zbssc ji im`ijgmzb ji tuncrg bd `cdcm-rgttc ckmi 2


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Pudd’bssg jgddg bs`issg bffibnc jispcstc kdi stbti bngri`bmi, ngmtrg dg crjimbtg imji`bmc mgd

`bsc jgddb dimgb rcssb id mungrc ji pgrscmg ckmi 2


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\gmmsydvbmib 0


8/28

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beeijbrg `cm siùrgzzb bd ncjgddc dimgbrg, tuttbvib ritgmibnc ji mcm pctgr trbsùrbrg um `grtc

dgkbng trb db vbribfidg ji imkrgssc g db vbribfidg ji usìtb. Kubrjbmjc id krbei`c, imebtti,

pcssibnc mctbrg `cng db muvcdb ji pumti si bjjgmsi imtcrmc bddb rgttb ji rgkrgssicmg

bs`gmjgmtg.

Jgeimibnc i rgsijui `cng dg jieegrgmzg trb i vbdcri geegttivi jgddb vbribfidg ji usìtb Y g i vbdcri

bttgsi, ìcï id vbdcrg òg db vbribfidg Y bssungrgffg sg sgkuissg gsbttbngmtg db rgdbzicmg

dimgbrg.

Id mcrnbd prcfbfidity pdct ï umb tg`mi`b krbei`b òg pgrngttg ji visubdizzbrg sikmiei`btivi

jis`cstbngmti jbddb jistrifuzicmg mcrnbdg. Pudd’bssg x vi scmc i rgsijui jispcsti im crjimg

`rgs`gmtg, sudd’bssg y i qubmtidi jgddb mcrnbdg stbmjbrj `bd`cdbti b pbrtirg jbddb eumzicmg ji

ripbrtizicmg gnpiri`b. Pg id krbei`c òg mg risudtb bsscnikdib bj umb rgttb b `cgeeiìgmtg

bmkcdbrg pcsitivc, bddcrb id `bnpicmg cssgrvbtc si bvviìmb bddb mcrnbditì. Bddcmtbmbngmti

jbddb rgttb c jgecrnbzicmi sikmiei`bmc òg id `bnpicmg mcm puö gssgrg `cmsijgrbtc mcrnbdg.

Mgd mcstrc `bsc i rgsijui si jispcmkcmc bpprcssinbtivbngmtg su umb rgttb, bmòg sg mgd tgrzc

qubjrbmtg i pumti si jispgrjcmc.

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ZGPZ JI ACDNCKCVCU PNIVMCEE \GV DB MCVNBDIZÌ JGI VGPIJWI

Jcpc bvgr cssgrvbtc db jistrifuzicmg jgi rgsijui `cm id Mcrnbd \rcfbfidity \dct, bmjibnc b

tgstbrg d’ ipctgsi `og qugsti sibmc jistrifuiti mcrnbdngmtg `cm ngjib " ukubdg bddb ngjib

`bnpicmbrib jgi rgsijui g `cm vbribmzb !6 pbri bd rbppcrtc

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Zbfgddb jgd tgst ji Acdnckcrcv-Pnirmcv

Ptbtc Vgsijui Vgsijui stj h/m (h-2)/m EJV tgcri`b |E(x)-h/m| |E(x)-(h-2)/m|Bdbfbnb -0,9:


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ZWNCVG BDDB \VCPZBZB GJ GZMIB JI \VCUGMIGMXB

Im qugstc ncjudc si prcpcmg d’cssgrvbzicmg jgd dgkbng trb ebttcri kgmgtiì jcvuti bdd’gtmib ji

um imjivijuc g db jivgrsb imìjgmzb ji bdùmg ecrng tuncrbdi.

Bvgmjc cssgrvbtc umb gvijgmtg bmbdckib trb db jistrifuzicmg jgddb nimcrbmzb

bercbngri`bmb mgi jivgrsi stbti jgdd’Wmicmg g id tbssc ngjic ji imìjgmzb jgd `bm`rc bddbprcstbtb suddb pcpcdbzicmg, ì prcpcmibnc im qugstb sgjg ji bpprcecmjirg tbdg ipctgti`c

dgkbng cssgrvbmjcmg db `crrgdbzicmg.

B tbdg s`cpc geegttugrgnc um tgst ji imjipgmjgmzb g bmbdizzgrgnc id dgkbng dimgbrg trb db

`busb(bppbrtgmgmzb bdd’gtmib bercbngri`bmb) g d’geegttc(nbkkicrg imìjgmzb jgd `bm`rc

bddb prcstbtb).

Wm pc’ ji krbeiì@cmercmtc `busb-geegttc `cm krbei`c b dimgg

Pudd’bssg jgddg bsìssg bffibnc imsgritc i mcni jgkdi stbti bngri`bmi, ngmtrg suddg crjimbtg ï

prgsgmtg db pgr`gmtubdg ji bercbngri`bmi stbtc pgr stbtc(dimgb rcssb), db ngjib mbzicmbdg ji

bercbngri`bmi sud tctbdg jgddb pcpcdbzicmg (dimgb vicdb), g id mungrc ji `bsi ji `bm`rc bddb

prcstbtb ckmi 2


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Jistrifuzicmg jgddb pcpcdbzicmg bercbngri`bmb mgkdi Ptbti Wmiti

Mgd krbei`c scvrbstbmtg si mctb `cng db pcpcdbzicmg bercbngri`bmb sib nbkkicrngmtg

prgsgmtg bj gst, bj g``gzicmg jgd Mgw Obnpsoirg, Nbimg g Ugrncmt, `cm umb `cm

`cm`gmtrbzicmg pbrti`cdbrngmtg gdgvbtb mgddb zcmb ngrijicmbdg.

Zbssc ji imìjgmzb suddb pcpcdbzicmg bngri`bmb jgd `bm`rc bddb prcstbtb

Im qugstc sg`cmjb nbppb vgjibnc òg db zcmb suj-gst ob umb pgr`gmtubdg nbkkicrg ji

imjivijui òg obmmc `cmtrbttc id `bm`rc bddb prcstbtb, im dimgb `cm db `brtimb prg`gjgmtg im

ùi mgddb ngjgsinb zcmb ̀ ’ï umb nbkkicr ̀ cm`gmtrbzicmg ji pcpcdbzicmg bercbngri`bmb.

Imcdtrg mgddg brgg im ùi db pgr`gmtubdg ji bercbngri`bmi ï mctgvcdngmtg imegricrg, `’ï um

tbssc ji imìjgmzb jgd tuncrg rgdbtivbngmtg fbssc.

Mcm pcssibnc pgrö ritgmgrg `cnpdgtbngmtg vbdijb db `cmkgtturb rikubrjc bd dgkbng trb idebttcrg kgmgti`c g db `cmtrbzicmg jgd `bm`rc pciòé ncdti stbti (bj gsgnpic Wtbo g Edcrijb)

mcm sgkucmc qugstc trgmj.


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Zbfgddb jgi jbti

60:07

5%/* G P:@NBD/4> "&*) "*# "*''&$#

A:BB:0D3B>77B "&*) (*+ "*)"#&+

E147D L:H17: "%*- "*# "*&'&$#

.137D F:418/2: "%*- #(*- ,"*)(&$"

F1814:C1 "%*+ %*" "*"(+&"

A127:2: "%*( )*% "*%%%%%

Z>22BO85:2/: "%*' ""*# )*#('$#

\4H:2B:B "%*& "&*' ,)*#&++%

W:BD/2=4:BH: "$*( %*& )*)$+-&

F:8/6142/: "$*' '*' ,)*#'+(%

_D/1 "$*' "#*# ,)*+##&+

_4> "$*% "*" )*)("

9>4@127 "$*$ )*- ,)*))&)"

V1G: "$*$ #*- ,)*#)#+"

R>2730HO "#*- (*+ ,"*)+(%#

Y814/C: "#*+ "&*- ,"*-++&"

U>X:B "#*( ""*" ,"*'"$(-

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@cmsijgrbtc um `bnpicmg cnckgmgc ̀ og tgmkb ̀ cmtc jgdd’im`ijgmzb jgddb nbdbttib sui

jivgrsi kruppi gtmi`i g db pgr`gmtubdg ji imjivijui bppbrtgmgmti bi qubttrc nb`rckruppi

`cmsijgrbti, db tbfgddb ribssumtivb jgddg cssgrvbzicmi sbrì8

Uckdibnc tgstbrg8

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ZWNCVG BI \CDNCMI G EWNC

Id eunc ji sikbrgttb ï db prim`ipbdg `busb ji nbdbttig ncrtbdi mgkdi Ptbti Wmiti, bj gssc scmcjcvuti :?


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Zbssc ji im`ijgmzb ji tuncrg b pcdncmi g frcm`oi ckmi 2


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@cmercmtc `busb-geegttc `cm krbei`c b dimgg

Pudd’bssg jgddg bs`issg bffibnc jispcstc kdi stbti bngri`bmi, ngmtrg dg crjimbtg imji`bmc mgd

`bsc jgddb dimgb rcssb id mungrc ji pgrscmg ckmi 2


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0%).&&% 8:G:4> #)*) #"*( '%*$

L/B74/07 16 F183@=/: #)*) #)*+ &&*+

Y814/C: "*+ "-*$ '"*)

M>14X:B &*' "-*# &%*"

^7:D "&*" ""*+ $-*$

9>4@127 )*( "-*" '&*(

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20/28

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VGKVGPPICMG DIMGBVG FIUBVIBZBZbfgddb 2

!"#"$%"$ ()**# +),+)%%$-.) /#*-+)

[ @387/N81 )*-"$"+#'(#

[ :8 ]3:C4:71 )*+$$-)#&-#

[ :8 ]3:C4:71 0144>771 )*+#')%+&

S4414> B7:2C:4C $*$$&"'"&(#

_BB>45:Q/12/ %+

Zbfgddb 6

mungrc ji `bsi ji `bm`rc bi pcdncmi ckmi 2 6 -


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Zbfgddb jgi jbti suddb rgdbzicmg trb pgr`gmtubdg ji eunbtcri g `bm`rc bi pcdncmi

6+%+* I H2$%+"#* B?;*07/037 "(*" '#*" &$*($'$ ,+*$'$(

L>8:G:4> #"*( '%*$ '$*%(() ,)*+#$)

L/B74/07 16 F183@=/: #)*+ &&*+ '"*&("# &*(("#

Y814/C: "-*$ '"*) &+*$-%- ,#*')&"

M>142730HO #-*) +)*" (+*-$&" ,"*"'%-

J13/B/:2: #&*( '-*+ ("*-%(# #*"%(#

A:/2> ##*+ '-*# '&*+)'$ ,$*$-$(

A:4O8:2C "-*" &'*( &(*-("% "*#("%

A:BB:0D3B>77B "+*# &&*+ &'*)'&' )*#'&'

A/0D/G A>X/01 #"*& '#*# '$*)&$& )*+&$&

E>G I14H "+*" '"*' &&*+&$+ ,&*(%'#

E147D F:418/2: #"*+ '+*% '$*'+++ ,%*(""#

E147D L:H17: #"*- &+*' '$*-))& &*$))&

_D/1 #&*" '+*' ()*'('( #*)('(

_H8:D1@: #'*" ()*# (#*(-%# #*&-%#

_4>22BO85:2/: ##*% ''*" '%*-&-$ ,"*"%)(

[D1C> VB8:2C #)*) '$*# &-*+((# ,$*$##+

.137D F:418/2: #$*" '&*$ ''*%%"' "*"%"'

.137D L:H17: #$*) '(*) ''*##-+ ,)*(()#

U>22>BB>> #$*) '%*+ ''*##-+ "*%#-+

U>X:B "-*# &%*" &+*"+$" %*)+$"

^7:D ""*+ $-*$ %#*&"$$ $*#"$$

9>4@127 "-*" '&*( &(*-("% ,(*(#+'

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Vgkrgssicmg dimgbrg umivbribtb g bmbdisi jgi rgsijui

Im qugstc krbei`c si ipctizzb d’gsistgmzb ji um dgkbng dimgbrg trb pgr`gmtubdg ji eunbtcri g

imìjgmzb jgd `bm`rc bi pcdncmi mgi simkcdi stbti.

Ckmumc ji gssi ï rbpprgsgmtbtc jb um pumtc \8

• D’bsìssb jgd pumtc x(\) rbpprgsgmtb db pgr`gmtubdg ji eunbtcri mgddc Ptbtc

rbpprgsgmtbtc jb \

• D’crjimbtb jgd pumtc y(\) rbpprgsgmtb id tbssc ji imìjgmzb jgddb ecrnb tuncrbdg

im qugsticmg su um tctbdg ji 2


23/28

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Vgsijui@i bspgttibnc `og i rgsijui bffibmc bpprcssinbtivbngmtg ngjib muddb .

6+%+* O./*07/037 ,+*$'$()"&''

L>8:G:4> ,)*+##-++$)$

L/B74/07 16 F183@=/: &*(("#"--(#

Y814/C: ,#*')&)--&("

M>14 ,$*$-$'+($)&

A:4O8:2C "*#("$-""&(

A:BB:0D3B>77B )*#'&&--%$#

A/0D/G P:@NBD/4> ,"*)-$$%%-$%

E>G K>4B>O ,&*%-+-'&%(%

E>G A>X/01 )*+&$&)#%#&

E>G I14H ,&*(%'"&)%

E147D F:418/2: ,%*(""#$$''(

E147D L:H17: &*$)))-()

_D/1 #*)('''-$#(

_H8:D1@: #*&-%#"&'++

_4>X:B %*)+$"%&(-$

^7:D $*#"$$)#("+

9>4@127 ,(*(#+')++%$

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Cncsògjbstì itì jgi rgsijui

Pudd’bssg jgddg bsìssg vi ï db pgr`gmtubdg ji eunbtcri mgkdi stbti bngri`bmi, ngmtrg sudd’bssg

jgddg crjimbtg vi scmc id vbdcrg jgi rgsijui.

Mctibnc òg i rgsijui mcm sgkucmc um bmjbngmtc mctgvcdg, id òg ì eb fgm spgrbrg

rikubrjc db dcrc mcrnbditì, im qubmtc db jieegrgmzb jbd vbdcrg bttgsc (sg`cmjc db rgkrgssicmg

dimgbrg) jgd vbdcrg geegttivc rgkistrbtc mcm ncstrb umb jipgmjgmzb inngjibtbngmtg visifidg

jbd vbdcrg jgddb vbribfidg ji imkrgssc _.

D'cncsògjbstiìtì ï umb `cmjizicmg ijgbdg mgddb qubdg si trcvb umb eumzicmg ji jbtirbpprgsgmtbfidi krbei`bngmtg `cng jispgrsi im nbmigrb bffbstbmzb cnckgmgb bd ji scprb

cj bd ji scttc ji umb dimgb rgttb.

Db muvcdb jgi rgsijui rispgttb db jgeimizicmg scvrbstbmtg pciòé si jistrifuis`g piuttcstc

cnckgmgbngmtg sudd’brgb jgd krbei`c.

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25/28

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I pumti si jispcmkcmc `cm fucmb bpprcssinbzicmg bttcrmc bj umb rgttb pbssbmtg pgr

d’crikimg, g``gzicm ebttb ji bdùmi pumti `cm vbdcri ncdtc bdti c fbssi8 pcssibnc quimji

bssungrg òg i rgsijui sgkubmc umb jistrifuzicmg mcrnbdg ji ngjib " # $ ! # #$

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Pg db tbkdib m jgd `bnpicmg ï pbri `cmsijgrgrgnc n>m/6, im `bsc ji jispbritì n>(m-2)/6.

Id vbdcrg ji n ì sgrvirì crb pgr `bd`cdbrg db stbtisti`b tgst.

Jgeimitc f `cng8

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&+#!$$>#

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jcvg i vbdcri bi scmc `cgeeiìgmti vbribfidi b sg`cmjb jgd vbdcrg ji m, db stbtisti`b tgst [ sbrì

ukubdg b8

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I vbdcri jgddb stbtisti`b tgst ji Pobpirc-[ida scmc `cnprgsi trb < g 2 g vgmkcmc `cmercmtbti `cm

dg tbvcdg bppcsitbngmtg `cstruitg pgr id tgst.

Bppbrg gvijgmtg òg, sg `cmsijgribnc id `bnpicmg crjimbtc `rgs`gmtgngmtg, im `bsc ji m

jispbri, gssgmjc f db scnnb pgsbtb(`ci `cgeeiìgmti bi) jgddg jieegrgmzg trb i tgrnimi jgd`bnpicmg gquijistbmti jbddb ngjibmb, mcm vgrrì utidizzbtc, mgd `bd`cdc ji f, id vbdcrg jgddb

ngjibmb stgssb.

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26/28

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ZBFGDDB VIG\IDCKBZIUB JGD ZGPZ JI POB\IVC-[IDA

PZBZI VGPIJWI BJJGMJI JI PP BJJGMJI JI f @CGEE UBDCVG @CGEE@cmmg`ti`ut -?,550; ;7,


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Pcstitugmjc bddb vbribmzb id suc stinbtcrg!!"

#!! pcssibnc `cstruirg um imtgrvbddc jgddb ecrnb

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Neoplasie e Fattori Di Rischio

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