CURRICULUM VITAEVia Giovanni Battista Grassi 74 20157, Milano Tel.: 02-503 19865 02-3904 2714 Fax:...

Pantoni L. - Curriculum vitae

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CURRICULUM VITAE

Prof. LEONARDO PANTONI

Medico

Specialista in Neurologia

Dottore di Ricerca in Neuroscienze

Professore Ordinario, settore scientifico disciplinare MED26 Neurologia

Dipartimento di Scienze Biomediche e Cliniche “L. Sacco”

Università degli Studi di Milano

Direttore U.O.C. Neurologia

Ospedale Luigi Sacco

Milano

Data di aggiornamento: 15 Novembre 2018


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Prof. Leonardo Pantoni Luogo e data di nascita: Firenze, 15 Ottobre 1964 Recapito professionale: Dipartimento di Scienze Biomediche e Cliniche 'L. Sacco'

Università degli Studi di Milano U.O.C. Neurologia Ospedale Luigi Sacco, padiglione 3 Via Giovanni Battista Grassi 74 20157, Milano

Tel.: 02-503 19865 02-3904 2714

Fax: 02-3567524 Email: [email protected]

STUDI COMPIUTI E TITOLI CONSEGUITI: Liceo scientifico "Leonardo da Vinci", Firenze Settembre 1978 - Giugno 1983 Diploma di maturità scientifica Luglio 1983 Voto: 60/60 Corso di laurea in Medicina e Chirurgia Università degli Studi di Firenze Novembre 1983 - Luglio 1989 Laurea in Medicina e Chirurgia il 23 Ottobre 1989 Tesi: "Fattori precipitanti le poussées nella sclerosi multipla. Disegno di studio e risultati preliminari" Relatore: Prof. Luigi Amaducci Voto: 110 e lode/ 110 Scuola di Specializzazione in Neurologia Università degli Studi di Firenze Direttore Prof. Luigi Amaducci Dicembre 1989 - Luglio 1993 Diploma di specialista in Neurologia il 15 Luglio 1993 Tesi: "Attitudini fobiche ed eventi stressanti recenti nell'amnesia globale transitoria" Relatore: Prof. Domenico Inzitari Voto: 70 e lode/ 70


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Studi compiuti e titoli conseguiti (continua) Research Fellowship Department of Pathology, Division of Neuropathology Henry Ford Hospital, Detroit, Michigan (USA) Division Head: Julio H. Garcia, M.D. Agosto 1993 - Giugno 1995 Dottorato di Ricerca in Neuroscienze Dipartimento di Scienze Neurologiche e Psichiatriche Università degli Studi di Firenze Coordinatori: Prof. Luigi Amaducci (1994-1997), Prof. Domenico Inzitari (1997-1998) Novembre 1994 - Ottobre 1998 Titolo di Dottore di Ricerca il 1 Febbraio 1999 Tesi: "Alterazioni della sostanza bianca cerebrale: aspetti clinici, radiologici, patogenetici e sperimentali" CORSI DI SPECIALIZZAZIONE: Corso di Neuroepidemiologia Sezione di Neuroepidemiologia della Società Italiana di Neurologia Roma, Università La Sapienza, 12-16 Febbraio 1990 Corso "Applicazione e calcolo di curve di sopravvivenza" Sezione di Neuroepidemiologia della Società Italiana di Neurologia Perugia, 24-25 Novembre 1992 Corso di Neuropatologia Department of Pathology Henry Ford Hospital, Detroit, Michigan, USA 2 Gennaio - 31 Marzo 1994 CORSI DI FORMAZIONE: Gestione Efficace in ottica di Qualità Totale Azienda Ospedaliera Careggi Firenze, 22 Aprile 1999 Basic Life Support (esecutore) Azienda Ospedaliera Careggi Gruppo Italiano di Rianimazione Cardiopolmonare Firenze, 29 Maggio 2000


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Corsi di formazione (segue) Defribillazione Precoce (esecutore) Gruppo Italiano di Rianimazione Cardiopolmonare Azienda Ospedaliera Careggi Firenze, 31 Ottobre 2000 Advanced Life Support Italian Resuscitation Council Azienda Ospedaliero Universitaria Careggi Firenze, 26-28 Gennaio 2005 Le strutture sanitarie nel sistema di prevenzione della corruzione: obblighi di pubblicazione, trasparenza ed integrità. Azienda Ospedaliero Universitaria Careggi Firenze, 17 Novembre 2014 POSIZIONE: Specializzando della Scuola di Specializzazione in Neurologia Università degli Studi di Firenze Dicembre 1989 - Luglio 1993 Investigator, Progetto Finalizzato Invecchiamento, Sottoprogetto Studio Longitudinale (finanziato dal Consiglio Nazionale delle Ricerche) Presidente Prof. Luigi Amaducci Gennaio 1992 – Luglio 1993 Borsista per l’estero, Università degli Studi di Padova Agosto 1993 – Luglio 1994 Research Fellow, Department of Neuropathology Henry Ford Hospital, Detroit, Michigan, USA Agosto 1993 – Giugno 1995 Dottorando di Ricerca in Neuroscienze Dipartimento di Scienze Neurologiche e Psichiatriche Università degli Studi di Firenze Novembre 1994 – Ottobre 1998 Collaboratore Tecnico di VII livello Dipartimento di Scienze Neurologiche e Psichiatriche Università degli Studi di Firenze 1 Novembre 1997 – 8 Febbraio 1998


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Posizione (segue) Dirigente Medico di I livello U.O. Neurologia Azienda U.S.L. n.3 Pistoia 9 Febbraio 1998 – 30 Settembre 1998 Dirigente Medico di I livello SOD Stroke Unit e Neurologia, Azienda Ospedaliero Universitaria Careggi 1 Ottobre 1998 – 1 Marzo 2015 Responsabile di struttura semplice intraSOD (“Gestione delle cerebropatie su base microvascolare”) SOD Stroke Unit e Neurologia, Azienda Ospedaliero Universitaria Careggi Dal 2008 al 2017 Professore Associato, settore scientifico disciplinare MED26 Neurologia Dipartimento di Neuroscienze, Psicologia, Area del Farmaco e Salute del Bambino (NEUROFARBA) Università degli Studi di Firenze 2 Marzo 2015 – 31 Ottobre 2017 Attribuzione di funzione di sostituzione temporanea/supporto del direttore di struttura complessa. SOD Stroke Unit e Neurologia, Azienda Ospedaliero Universitaria Careggi 1 Dicembre 2016 - 31 Ottobre 2017 Professore Ordinario, settore scientifico disciplinare MED26 Neurologia Dipartimento di Scienze Biomediche e Cliniche 'L. Sacco' Università degli Studi di Milano e Direttore U.O.C. Neurologia Ospedale Luigi Sacco, Milano Dal 1 Novembre 2017 ad oggi CONOSCENZA LINGUE STRANIERE Lingua: inglese • Capacità di lettura: eccellente • Capacità di scrittura: eccellente • Capacità di espressione orale: eccellente


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ESPERIENZE PROFESSIONALI CLINICHE E ASSISTENZIALI Neurologia clinica: Gestione intensiva e sub-intensiva del paziente con ictus in fase acuta e subacuta (inclusa l’attività di Stroke Team per procedure per trombolisi sistemica ed intrarteriosa). Diagnosi, terapia, prevenzione primaria e secondaria dell’ictus cerebrale.

Specifico interesse in pazienti affetti da ictus cerebrale, deterioramento cognitivo di origine vascolare, amnesia globale transitoria e in pazienti sottoposti ad interventi cardiochirurgici.

Esperienza nella diagnosi e cura del paziente affetto da patologia neurologica acuta (Neurologia d’urgenza)

Esperienza clinica con pazienti neurologici e con pazienti geriatrici, principalmente nel campo delle malattie cerebrovascolari, delle demenze, della sclerosi multipla e del morbo di Parkinson.

Esperienza nella organizzazione e conduzione di trial terapeutici controllati e randomizzati. Responsabilità di struttura semplice intraSOD. Responsabilità di Unità Operativa Complessa di Neurologia con annessa Stroke Unit. Neuroradiologia: Esperienza con le moderne tecniche di tomografia computerizzata e risonanza magnetica, con particolare riferimento alle alterazioni età-associate e al campo del deterioramento cognitivo. Esperienza con sistemi computerizzati per l’analisi di immagini di risonanza magnetica nucleare. Esperienza specifica nel campo delle alterazioni della sostanza bianca e degli aspetti neuroradiologici della malattia dei piccoli vasi, in particolare per quanto concerne la valutazione visiva, le diverse classificazioni e le correlazioni fra aspetti clinici, radiologici e patologici. Utilizzazione in ambito clinico delle moderne tecnice di RM (diffusione, sequenze gradient-echo, dimensione frattale, ecc.) RM funzionale. Altre esperienze assistenziali: Ufficiale Medico dell’Esercito Italiano, Caserma Predieri Firenze, Agosto 1990 – Luglio 1991 Sostituto incaricato di Guardia Medica Firenze, USL 10/D, Agosto 1992


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ESPERIENZE DI RICERCA SPERIMENTALE e DI LABORATORIO Neuropatologia: Esperienza con le tecniche dell’esame neuropatologico macroscopico e microscopico.

Tecniche di microscopia ottica applicabili allo studio delle malattie degenerative del sistema nervoso centrale (in particolare alle demenze) e alle malattie cerebrovascolari.

Microscopia a luce polarizzata. Tecniche di immunoistochimica (es. anticorpi anti beta-A4 amiloide ed anti- GFAP – glial fibrillary acidic protein-).

Esperienza con le tecniche di analisi computerizzata delle immagini su materiale neuropatologico umano ed animale. Ischemia cerebrale sperimentale:

Approfondita conoscenza della tecnica di occlusione dell'arteria cerebrale media mediante inserzione di filamento intraluminale nell'arteria carotide esterna e della tecnica di legatura bilaterale delle arterie carotidi nel ratto Wistar.

Analisi neurocomportamentale e neuromotoria nel ratto Wistar. Analisi computerizzata delle immagini su materiale neuropatologico umano ed animale.

PRINCIPALI LINEE DI RICERCA (documentate da pubblicazioni): Demenza e deterioramento cognitivo vascolare: epidemiologia, correlazioni clinico-

patologiche, neuroimaging, trial terapeutici. Malattia dei piccoli vasi cerebrali: classificazione, patogenesi, correlati clinici e aspetti

terapeutici e nuove frontiere della neuroradiologia. Patologia della sostanza bianca cerebrale età-correlata: aspetti clinici, neuroradiologici e

patologici e loro correlazioni. Neuropatologia della demenza vascolare e delle demenze in genere. Malattie ereditarie e genetiche cerebrovascolari con particolare riferimento alla CADASIL

(Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy)

Ischemia cerebrale sperimentale (focale e globale). Prevenzione secondaria e primaria delle malattie cerebrovascolari. Fattori di rischio per le malattie vascolari e il deterioramento cognitivo. Malattie neurologiche legate all'invecchiamento. Complicanze neurologiche degli interventi cardio-chirurgici. Amnesia globale transitoria. Complicanze neurologiche della fibrillazione atriale. Aspetti infiammatori dell'ischemia cerebrale. Epidemiologia della demenza e del deterioramento cognitivo


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BORSE DI STUDIO E PREMI: Borsa di studio bandita dall'Università di Padova per un periodo di ricerca di 12 mesi presso una struttura estera (Agosto 1993 - Luglio 1994) Premio "Neuroscienze cliniche e di base con particolare riguardo alle malattie cerebrovascolari, alle cefalee, alle epilessie" sostenuto dalla Glaxo S.p.A. sotto l'egida della Società Italiana di Neurologia (Roma, Novembre 1995, XXIX Congresso Nazionale). Premio Dr. Belarmino Rodriguez Arias Conferito in occasione del congresso nazionale della Società Spagnola di Neurologia Valencia, 19 Novembre 2015


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COLLABORAZIONI INTERNAZIONALI (selezione): Department of Pathology (Division of Neuropathology), Henry Ford Hospital, Detroit, Michigan, USA: studio neuropatologico delle alterazioni della sostanza bianca cerebrale causate da ischemia (1993-1998). Antenne de Neuropathologie, Hopital Roger Salengro, Lille, France Prof. Marie-Magdaleine Ruchoux: analisi neuropatologica di casi affetti da sospetto CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencepahlopathy) (1996-2000). Unité de Recherche de l'Inserm U 25, Hopital Saint-Antoine, Paris, France Laboratorio della Dr.ssa Elisabeth Tournier-Lasserve: analisi genetica di casi con sospetto CADASIL (1996-1998). Department of Clinical Neurosciences, Helsinki University Central Hospital, Helsinki, Finland (Timo Erkinjuntti, MD, PhD) e Institute of Clinical Neuroscience, Göteborg University, Mölndal, Sweden (Anders Wallin, MD, PhD): analisi dell'efficacia della nimodipina in pazienti affetti da demenza vascolare sottocorticale e multi-infartuale arruolati nello "Scandinavian Multi-infarct Dementia Trial" (1998-2000). European Task Force on Age-Related White Matter Changes, gruppo di studio formato dai principali ricercatori europei nel campo delle alterazioni della sostanza bianca legate alle malattie cerebrovascolari e ai disturbi cognitivi (1996-2002). Neuropsychiatric Epidemiology Unit, The Sahlgrenska Academy, Institute of Clinical Neurosciences, University of Göteborg (Ingmar Skoog, MD, PhD): “Evaluation of brain CT-scans in two large population-based studies performed in Göteborg, Sweden” (2002 - al presente). Deputy Coordinator e Publication Coordinator dello Studio LADIS (Leukoaraiosis and Disability in the Elderly), studio collaborativo multicentrico (11 centri europei) finanziato dall’Unione Europea (2000 al presente).

Neurologische Klinik und Poliklinik, Ludwig-Maximilians-Universität, Munich, Germany (coordinatore Prof. Martin Dichgans), co-referente italiano per lo studio “Genome-wide search for quantitative trait loci for radiographic white matter hyperintensities in CADASIL” condotto dall’European CADASIL Consortium (2009 al presente).

COEN (Centres of Excellence in Neurodegeneration) per lo studio “Standards for determining the vascular contribution to neurodegeneration” in collaborazione con Canadian Institutes of Health Research (CIHR, Canada), Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE, Germany), Medical Research Council (MRC, UK) (dal 2012 al presente)


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Collaborazioni internazionali (segue) Working Group "Realising the potential of cohort studies to determine the vascular contribution to neurodegeneration" (P.I. Joanna Wardlaw, UK) Joint Programme - Neurodegenerative Disease (JPND) Research Call for Working Groups to Inform Cohort Studies in Neurodegenerative Disease Research (dal 2014 al presente) Vascular Impairment of Cognition Classification Consensus Study (VICCCS) Collaborazione internazionale sponsorizzata dalla Alzheimer's Society sulla armonizzazione dei criteri diagnostici per il Mild Vascular Cognitive Impairment Principle Investigators: Patrick Kehoe, Seth Love, Yoav Ben-Shlomo (Bristol University, UK) Peter Passmore (Queen’s University Belfast, Northern Ireland) (dal 2010 al presente) Membro del Scientific Advisory Board come independente Ethics Advisor CoSTREAM (Common mechanisms and pathways in stroke and Alzheimer’s disease) Understanding Stroke and Alzheimer Progetto collaborativo fra 11 centri finanziato dall’Unione Europea (>5 milioni di euro) nell’ambito del bando Horizon 2020 Coordinator: Prof. Cornelia van Duijn Erasmus Medical Center, Rotterdam/NL (dal 2016 al presente) Canadian Consortium on Neurodegeneration in Aging (CCNA) External advisor for the development of Clinical Trials for Vascular Cognitive Impairment (P.I. Prof. Eric Smith, University of Calgary) (dal 2016 al presente) Membro del progetto collaborativo HARmoNising Brain Imaging MEthodS for VaScular Contributions to Neurodegeneration (HARNESS) supportato dal Joint Programme - Neurodegenerative Disease (JPND) (P.I. Prof. Eric Smith, University of Calgary) (dal 2016 al presente)

http://alzheimers.org.uk/

http://www.bris.ac.uk/clinicalsciencenorth/dementia/staffprofiles/pat

https://www.bris.ac.uk/clinicalsciencenorth/dementia/staffprofiles/seth

http://www.bristol.ac.uk/neuroscience/people/person/12787

http://www.qub.ac.uk/research-centres/CentreforPublicHealth/Staff/StaffProfile/?school=ccrcb&ns=e6bc0e107ecbce6ff990234242f953a6b0ab41978862c363d0c67e512321cb89&page=general

http://www.erasmusmc.nl/?lang=en


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FINANZIAMENTI PUBBLICI (sintesi) (Nota: a ruolo ospedaliero fino al Febbraio 2015 e quindi non ammissibile amministrativamente come coordinatore o responsabile di centro a progetti MIUR) 1) Programma per la Ricerca Regionale in Materia di Salute 2009. Progetto: “Evaluation of Notch3 mutations and correlation with clinical phenotypes” Responsabile: Prof. Antonio Federico (Siena) Ruolo: coordinatore di centro 2) Bando Ricerca Finalizzata / Giovani Ricercatori 2010 - Ministero Salute – RF-2010-2321706, titolo: “The rehabilitation of attention in patients with mild cognitive impairment and brain subcortical vascular changes using the Attention Process Training-II” Ruolo: responsabile del progetto

3) Studio LADIS (Leukoaraiosis and Disability in the Elderly) promosso e finanziato dalla Unione Europea (grant QLRT-2000-00446) nell’ambito del Vth Framework programme. P.I.: Prof. Domenico Inzitari Ruolo: vice-coordinatore, responsabile dellla coordinazione del processo di pubblicazione (oltre 50 pubblicazioni indicizzate su PubMed) 4) MIUR Ministero dell’Istruzione, dell’Università e della Ricerca, programmi di ricerca cofinanziati-2006 (MIUR 2006-prot.2006065719) “Fattori di rischio, marker di danno endoteliale e fattori emodinamici associati alla leucoencefalopatia su base microvasculopatica” P.I.: Prof. Domenico Inzitari Ruolo: coordinatore di centro, primo aiuto al PI 5) MIUR Ministero dell’Istruzione, dell’Università e della Ricerca, programmi di ricerca cofinanziati-2009 (MIUR 2009-prot. 20095JPSNA), “Studio genetico, della funzione endoteliale e con neuroimaging avanzato di forme sporadiche e familiari (CADASIL e CADASIL-like) di microangiopatia cerebrale” P.I.: Prof. Domenico Inzitari Ruolo: coordinatore di centro, primo aiuto al PI 6) Italian coordinator for the study “Genome-wide search for quantitative trait loci for radiographic white matter hyperintensities in CADASIL” performed within the European CADASIL Consortium (principal investigator Prof. Martin Dichgans, Neurologische Klinik und Poliklinik, Ludwig-Maximilians-Universität, Munich, Germany) Ruolo: responsabile di centro e coordinatore nazionale


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Finanziamenti pubblici (segue) 7) Vascular Mild Cognitive Impairment Tuscany Study (VMCI-Tuscany). Rischio e determinanti di demenza in pazienti con deterioramento cognitivo lieve ed alterazioni vascolari sottocorticali dell’encefalo. Studio dei marker clinici, di neuroimmagini e biologici. Programma per la Ricerca Regionale in Materia di Salute 2009 (Regione Toscana) P.I.: Prof. Domenico Inzitari Ruolo: coordinatore di centro, primo aiuto al PI


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ATTIVITA' DIDATTICHE: (Nota: a ruolo ospedaliero fino al Febbraio 2015) Università degli Studi di Firenze Tutor e correlatore nelle seguenti tesi sperimentali in Medicina e Chirurgia: 1) Marco Romanelli: "La demenza vascolare: revisione dell'inquadramento

nosografico e dei meccanismi fisiopatologici. Studio dell'incidenza di demenza vascolare dopo stroke in 635 pazienti inclusi in un registro ospedaliero" (A.A. 1995-96).

2) Michela Simoni: "Lesioni radiologiche della sostanza bianca encefalica di origine vascolare: significato patologico e clinico e metodi di valutazione" (A.A. 1998-99)

3) Elisabetta Bertini: "Amnesia globale transitoria: aspetti patogenetici e valutazione prognostica mediante studio controllato di follow-up in 46 casi" (A.A. 1998-99) 4) Marco Inzitari: “La depressione vascolare: aspetti fisiopatologici e nosografici. Valutazione pilota degli strumenti di definizione clinica” (A.A. 2000-01).

5) Francesca Pescini: “CADASIL: aspetti clinici, genetici e neuroradiologici in due famiglie italiane. Confronto con casi sporadici di leucoencefalopatia vascolare ad insorgenza giovanile” (A.A. 2001-02) 6) Raffaella Valenti: “Disturbi psichiatrici nella CADASIL. Studio caso-controllo su disturbi del tono dell’umore, aspetti ossessivo-compulsivi e riconoscimento delle espressioni facciali” (A.A. 2006-07). 7) Serena Nannucci: “Screening e diagnosi di CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) presso una struttura di riferimento regionale per le malattie cerebrovascolari” (A.A. 2006-07) 8) Marco Pasi: “Valutazione di un test di screening cognitivo nella fase acuta dell’ictus: studio di fattibilità ed applicabilità” (A.A. 2009-10) 9) Guido Chiti: “Valore predittivo del MoCA (Montreal Cognitive Assessment) somministrato nella fase acuta dell’ictus sulla diagnosi di deterioramento cognitivo in un follow-up a medio termine” (A.A. 2011-12)

10) Lapo Borgheresi: “Leucoaraiosi e diabete mellito tipo 2. Dati trasversali e revisione sistematica della letteratura” (A.A. 2012-13)


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Tutor e correlatore nelle seguenti tesi sperimentali in Medicina e Chirurgia (UNIFI) (segue): 11) Carlotta Mancini: “I disturbi comportamentali e la loro valutazione in un ambulatorio dedicato ai disturbi neuro-cognitivi di origine vascolare” (A.A. 2015-16)

Tutor e relatore delle seguenti tesi di specializzazione in Neurologia:

1) Dr.ssa Cristina Sarti: “Lipoproteina(a) e patologie età-correlate: risultati di uno studio di popolazione” (A.A. 1999-2000)

2) Dr.ssa Monica Martini: “Depressione vascolare: diagnosi di depressione maggiore in

pazienti con leucoencefalopatia sottocorticale vascolare” (A.A. 2002-03) 3) Dr.ssa Michela Simoni: “Alterazioni della sostanza bianca età-correlata e disabilità. Lo

studio LADIS (Leukoaraiosis and Disability): caratteristiche dei pazienti, fattori di rischio vascolare, danno funzionale e progressione verso la disabilità ad un anno di follow-up” (A.A. 2003-04).

4) Dr.ssa Anna Poggesi: “Leucoaraiosi e disabilità nell’anziano: rischio di rapido declino

funzionale globale in soggetti anziani con leucoaraiosi grave. Lo studio LADIS (Leukoaraiosis and Disability) (A.A. 2005-06)

5) Dr.ssa Francesca Pescini: “CADASIL (Cerebral Autosomal Dominant Arteriopathy with

Subcortical Infarcts and Leukoencephalopathy): individuazione di 14 nuove famiglie e loro studio clinico e neuroradiologico con particolare riferimento allo sviluppo di criteri di screening pre-genetico” (A.A. 2006-07)

6) Dr.ssa Laura Ciolli: “Caratteristiche cliniche, profilo di rischio vascolare e profilo neuropsicologico dei pazienti affetti da leucoencefalopatia microangiopatica: risultati del MIcrovascular LEukoencephalopaty Study (MILES)” (A.A. 2009-10)

7) Dr.ssa Raffaella Valenti: “Deterioramento cognitivo vascolare lieve: aspetti clinici, di neuroimaging, e dati preliminary del Vascular Mild Cognitive Impairment Tuscany Study (VMCI-Tuscany)” (A.A. 2011-2012)

8) Dr.ssa Serena Nannucci: “Screening e diagnosi di CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) presso il centro di riferimento per le malattie cerebrovascolari di Firenze: caratteristiche geno- e feno-tipiche di 83 pazienti consecutivi, creazione della CADASIL scale e identificazione di pazienti CADASIL-like” (A.A. 2012-2013)

9) Dr. Sandro Marini: “Metodi di analisi computerizzata e visiva delle lesioni cerebrali e loro correlazione con le performance cognitive in pazienti con deterioramento cognitivo lieve di di presunta origine vascolare e degenerativa” (A.A. 2013-2014)


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Tutor e correlatore nelle seguenti tesi di specializzazione in Neurologia (UNIFI) (segue):

10) Dr. Marco Pasi: “Cerebral small vessel disease and intracerebral hemorrhage: new evidence on lacunes topography, cerebral atrophy and concomitant presence of lobar/deep bleeds in patients with intracerebral hemorrhage” (A.A. 2015-2016).

11) Dr. Fabio Fierini: “Studio retrospettivo e case series prospettica di pazienti con

dolicoarterie e dolicoectasie arteriose intracraniche. Dati demografici e clinici, relazione con la malattia dei piccoli vasi cerebrali e con alterazioni vascolari sistemiche”. (A.A. 2015-2016).

Altre attività didattiche Dal momento dell’istituzione del ruolo di tutor all’interno della Scuola di Specializzazione in Neurologia dell’Università degli Studi di Firenze (2010), ha svolto tale ruolo per 9 specializzandi. Tutor e correlatore nella tesi in Scienze delle Professioni Sanitarie della Riabilitazione, Università degli Studi di Firenze, del candidato logopedista Santi Centorrino: “La riabilitazione precoce dell’afasia post-ictus: uno studio pilota sul recupero” (A.A. 2005-06)

Professore a contratto presso la Scuola di Specializzazione in Neurologia dell'Università degli Studi di Firenze a partire dall'A.A. 1998-99 fino all’entrata a ruolo come Professore Associato. Dal 2008 e al 2015, ha svolto il lavoro di coordinatore della Scuola di Specializzazione in Neurologia dell’Università di Firenze (direttore Prof. D. Inzitari) per quanto riguarda l’organizzazione delle lezioni, dei turni guardia e dei periodi di rotazione degli specializzandi. Professore a Contratto e docente di Neurologia presso la Scuola di Specializzazione in Neuropsichiatria Infantile dell'Università degli Studi di Firenze dall'A.A. 2001-02 all’A.A. 2006-07. Attività didattiche presso l’Università degli Studi di Firenze: Corso di laurea in LOGOPEDIA (ABILITANTE ALLA PROFESSIONE SANITARIA DI LOGOPEDISTA) (B166) Titolare dell’insegnamento B020243 – NEUROSCIENZE, ModuloB020244 - NEUROLOGIA Corso di laurea in SCIENZE E TECNICHE DELLO SPORT E DELLE ATTIVITÀ MOTORIE PREVENTIVE E ADATTATE (B185) Titolare dell’insegnamento B016931 - NEUROLOGIA

http://www.unifi.it/index.php?module=ofform2&mode=1&cmd=3&AA=2015&afId=395641




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Attività didattiche presso l’Università degli Studi di Firenze (segue): Corso di laurea in MEDICINA E CHIRURGIA (B120) Insegnamento B011751 - NEUROLOGIA (C.I.), Modulo B011754 - NEUROLOGIA Membro del Collegio dei docenti “Dottorato Toscano di Neuroscienze” a partire dall’anno accademico 2016-17




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Università degli Studi di Milano Relatore nelle seguenti tesi sperimentali in Medicina e Chirurgia:

1) Samuel Alberto Padelli: “Modifiche della connettività funzionale nel trauma cranico sportivo ricorrente: uno studfio fMRI” (A.A. 2017-18)

2) Anna Freddi: “La stimolazione binaurale nell’emicrania: valutazione di un trattamento

serale trimestrale” (A.A. 2017-18) 3) Giovanni Bianchi: “Valutazione del metabolismo ossidativo del muscolo scheletrico in

pazienti con malattia di Alzheimer”. (A.A. 2017-18) 4) Payam Tabaee Damavandi: “Shunt destro-sinistro e apnee notturne nella cefalea a

grappolo” (A.A. 2017-18)

5) Mariavittoria Maspes: “Attività onirica e abitudini del sonno nel paziente emicranico: studio caso-controllo” (A.A. 2017-18)

6) Federica Del Tedesco: “Il declino cognitivo in un campione di popolazione straniera nell’area milanese: Caratteristiche socio-demografiche, culturali e cliniche dei casi valutati presso il centro per il trattamento e lo studio dei disturbi cognitivi dell’ospedale Luigi Sacco dal 2001 al 2017” (A.A. 2017-18)

Relatore nelle seguenti tesi di specializzazione in Neurologia:

1) Dr.ssa Caterina Mariotti D’Alessandro: “Confronto fra regimi dietetici chetogenici e non chetogenici nella profilassi dell’emicrania cronica multiresistente” (A.A. 2016-17)

Correlatore nelle seguenti tesi di specializzazione in Oftalmologia:

2) Dr.ssa Alba Xhepa: “Sclerosi multipla e pigmento maculare” (A.A. 2015-16) Attività didattiche attuali Coordinatore corso integrato di Malattie del Sistema Nervoso (91.18.1) Università degli Studi di Milano Corso di Laurea in Medicina e Chirurgia, polo Vialba Coordinatore corso integrato di Neurologia MED 26 (semeiotica) (90.18.1) Università degli Studi di Milano Corso di Laurea in Medicina e Chirurgia, polo Vialba


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Attività didattiche attuali (segue) Docente Scuola Specializzazione in Neurologia Università degli Studi di Milano Membro del Consiglio della Scuola di Specializzazione in Medicina Tropicale Attività didattiche o similari svolte all’estero o in altri atenei Controrelatore (opponent) alla tesi di PhD della dr.ssa Ellen Garde “Age-related white matter changes in MRI. Evaluation of a possible relation to changes in cognitive function in a population of normal 80 year old subjects”. Faculty of Health Sciences, University of Copenhagen, 8 Maggio 2001. Membro della commissione di promozione per il titolo di PhD della dr.ssa Alida Gouw (“Cerebral small vessel disease on MRI. Clinical impact and underlying pathology”) Vrije Universitiet, Amsterdam, 20 Marzo 2009. Referee per la tesi di PhD del dr. Galit Weinstein “Vascular risk factors and their variability, atherosclerosis parameters and cognitive functions among patients with coronary heart disease”, Tel Aviv University, Novembre 2010. Revisore esterno (External Examiner) per il titolo di PhD presso la Newcastle University. Esame orale (“viva”) della tesi della dr.ssa Yumi Yamamoto “Characterisation of the neurovascular pathology in CADASIL: a model for subcortical vascular dementia”. Newcastle-upon-Tyne, 9 Marzo 2011. Revisore per la Scuola di Dottorato di Ricerca delle Facoltà di Medicina e Chirurgia dell’Università Politecnica della Marche della tesi “The role of obstructive sleep apnea syndrome in the pathogenesis and evoluation of dementia” della dr.ssa Laura Buratti (corso di Dottorato in Salute dell’Uomo, XV ciclo)


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INCARICHI EDITORIALI: Curatore e co-editore (con Domenico Inzitari e Anders Wallin) del libro: The Matter of White Matter. Clinical and pathophysiological aspects of white matter disease related to cognitive decline and vascular dementia. Utrecht, The Netherlands: Academic Pharmaceutical Productions, 2000 (438 pagine). Editore (con Philip Gorelick) del libro: Small Vessel Disease Cambridge University Press, 2014 (360 pagine) Referee per riviste scientifiche: New England Journal of Medicine; Lancet; JAMA; Lancet Neurology; Annals of Neurology; Alzheimer’s & Dementia; Circulation; Stroke; Neurology; Brain; Hypertension; Journal of Cerebral Blood Flow and Metabolism; BMJ Case Report; Nature Reviews Neurology; Archives of General Psychiatry; JAMA Neurology; Alzheimer’s Research & Therapy; Journal of Neurology; Neurobiology of Aging; Molecular Psychiatry; Human Mutation; British Journal of Psychiatry; Scientific Reports, Bioessays; Journal of Neurology Neurosurgery and Psychiatry; American Journal of Geriatric Psychiatry; Molecular Genetics and Metabolism; International Journal of Stroke; Pharmacology and Therapeutics; Brain Research; Neuroimage; Neuropathology and Applied Neurobiology; Cerebrovascular Diseases; Dementia and Geriatric Cognitive Disorders; Journal of Neuroimaging; Journal of the Neurological Sciences; Neuroepidemiology; European Journal of Neurology; BMC Neurology; Expert Review of Neurotherapeutics; Pharmacology Biochemistry and Behavior; Current Alzheimer Research; Experimental Neurology; Clinical Drug Investigation; Life Sciences; International Psychogeriatrics; European Neurology; Journal of the International Neuropsychological Society; Psychiatric Research: Neuroimaging; Journal of Pharmacy and Pharmacology; CNS Drugs; Neuroradiology; Tohoku Journal of Experimental Medicine; Acta Neurologica Scandinavica; Neuroscience Letters; Clinical Neurology and Neurosurgery; Journal of Drug Assessment; Aging Clinical and Experimental Research; Neurology India; Neurological Sciences (formerly, Italian Journal of Neurological Sciences).

Revisore per bandi di ricerca: Austrian Science Fund grant application (1998)

Alzheimer’s Association grant application (2001, 2007, 2008) Wellcome Trust (UK) (2004, 2011, 2013)

Health Research Board of Ireland (2006) Research Grants Council of Hong Kong (2009 e 2011) UK Alzheimer’s Society (2009)

Dunhill Medical Trust (2013) Alzheimer's Research UK (2013) UK Stroke Association (2014, 2015)


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Revisore per bandi di ricerca (segue): UK Medical Research Council (MRC) (2015) Agency for Health Quality and Assessment of Catalonia (AQuAS) (2017) Université de Bordeaux (2016, 2018) Altri incarichi di revisore

Revisore per la Cochrane Collaboration

Membro dell’Albo dei Revisori MIUR per la VQR 2011-14

Revisore MIUR progetti PRIN 2017

Advisory e Editorial Boards (attuali o passati): Membro del panel per lo sviluppo delle linea guida sull’"Impiego delle tecniche di imaging nelle demenze" dell’Istituto Superiore di Sanità.

Membro dell’expert panel sulla demenza vascolare della USA National Stroke Association Membro del comitato tecnico-scientifico dell’Italian Stroke Forum Network Membro dell’advisory board SPREAD (Stroke Prevention And Educational Awareness Diffusion) sulle linee guida italiane per la prevenzione ed il trattamento dell’ictus cerebrale (sezione sulle complicanze psico-cognitive dell’ictus cerebrale e sezione ictus giovanile)

Vice-coordinatore della sezione sulle complicanze psico-cognitive dell’ictus cerebrale delle linee guida ISO-SPREAD (Stroke Prevention And Educational Awareness Diffusion) Membro dello Steering Committee del Remember Project (Registry Evaluation Memory in Buttrio and Remanzacco) finanziato dalla regione Friuli Venezia Giulia (coordinatore, dr. Patrizio Prati) Membro dell’advisory panel del workshop "Vascular Cognitive Impairment: Harmonization Criteria" organizzato dal National Institutes of Neurological Disorders and Stroke a Washington, DC, il 24-27 Aprile 2005, e co-promosso da Canadian Stroke Network, The Institute of Ageing, The Institute of Circulatory and Respiratory Health and The Institute of Neuroscience, Mental Health and Addiction of the Canadian Institutes of Health Research, the Alzheimer’s Association, and the NIH Office of Rare Diseases. Membro della Associazione Italiana di Neurologia dell'Emergenza Urgenza – (ANEU) Responsabile dell’algoritmo sulle vertigini

Membro dell’International Scientific Advisory Committee della organizzazione non-profit CADASIL Together We Have Hope (CTWHH)


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Advisory e Editorial Boards (segue):

Membro del Centro Eccellenza Denothe, Università degli Studi di Firenze

Membro del Collegio dei Revisori dei Conti dell’Italian Stroke Organization-ISO Editorial Boards di riviste scientifiche:

Acta Neurologica Scandinavica: membro dell’Editorial Board (dal 2006) International Journal of Alzheimer’s Disease: membro dell’Editorial Board (dal 2009 al 2013)

Chairman del Publication Committee della International Psychogeriatric Association (2009-2011)

Stroke: Editor della sezione Vascular Cognitive Impairment (dal Luglio 2010)

Cerebrovascular Diseases: membro dell’Editorial Board (dal 2011) European Stroke Journal: membro dell’Editorial Board (dal 2016, anno di fondazione) Neurological Sciences: membro dell’Editorial board (dal 2018)


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ALTRI INCARICHI E CARICHE: Congressi scientifici (selezione): Membro del Program Committee First International Congress on Vascular Dementia Ginevra (Svizzera), 3-6 Ottobre 1999

Moderatore della sessione Pathophysiology e membro del writing committee della International Psychogeriatric Association Special Expert Conference Vascular Burden of the Brain – New Therapeutic Directions Madrid (Spagna), 28-30 Novembre 2001 Membro del Scientific Advisory Board Third Congress on Vascular Factors in Alzheimer's Disease Kyoto (Giappone), 7-10 Aprile 2002 Co-chairman del simposio “Subcortical vascular dementia: a new disorder?” 11th Congress of the Association of European Psychiatrists Stoccolma, Svezia, 5 Maggio 2002 Membro del Comitato Scientifico e moderatore XII Convegno Nazionale “Nuove Frontiere in Neurogeriatria” Bologna, 28-30 Novembre 2002 1st Congress of the International Society for Vascular Behavioural and Cognitive Disorders (Göteborg, Svezia, 28-31 Agosto 2003)

-Moderatore del simposio “Progression of white matter changes” -Moderatore del workshop “Subcortical vascular disease: impact on cognitive and mood disorders, disability and prognosis” -Moderatore della sessione poster “White matter lesions: clinical picture”

Co-chairman del Second Congress of the International Society for Vascular Behavioural and Cognitive Disorders (Firenze, 8-12 Giugno 2005). Membro del Scientific Advisory Committee 12° Congresso Internazionale della International Psychogeriatric Association "Aging with Dignity: new challenges, new possibilities, new solutions" Stoccolma, Svezia, 20-24 Settembre 2005 Membro del Comitato Scientifico European Regional Meeting 2006 International Psychogeriatric Association Lisbona, Portogallo, 3-6 Maggio 2006


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altri incarichi e cariche (segue): Membro della Commissione Scientifica del 1°, 2°, 3°, 4° Hipponion Stroke National Price Vibo Valentia, 17-19 Novembre 2006, 3-5 Ottobre 2008, 7-10 Ottobre 2010, 26-28 Ottobre 2012, 26-27 Ottobre 2014 Membro del Comitato Scientifico IPA European Regional Meeting 2007 International Psychogeriatric Association Istanbul, Turchia, 3-6 Maggio 2007 Membro del Comitato Scientifico del Third Congress of the International Society for Vascular Behavioural and Cognitive Disorders San Antonio, Texas, 11-14 Luglio 2007 Membro del Comitato di Coordinamento Locale del XXXVIII Congresso della Società Italiana di Neurologia Firenze, 13-17 Ottobre 2007 Membro del Comitato Scientifico del Fourth Congress of the International Society for Vascular Behavioural and Cognitive Disorders Singapore, 14-16 Gennaio 2009 Membro del comitato scientifico della conferenza nazionale sull’ictus Stroke a partire dal 2010 Membro permanente del Comitato Scientifico della European Stroke Conference Dal 2005 al 2014 Membro dell’International Stroke Conference Program Committee (2013-2016) e chairman per la categoria Vascular Cognitive Impairment Membro del Scientific Advisory Board della European Stroke Organization Conference (ESOC) A partire dalla sua fondazione nel 2015 Membro del Dementia Committee della European Stroke Organization (dal 2018) Membro del Local Planning Committee della 5ª European Stroke Organization Conference (Milano, 22-24 Maggio 2019)


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altri incarichi e cariche (segue): Partecipazione a trial clinici: Responsabile della revisione centralizzata delle tomografie computerizzate cerebrali dello studio italo-spagnolo "Efficacy and safety of nimodipine (Bay e 9736) in patients with subcortical vascular dementia: a double-blind, placebo controlled and multicenter study (study No. 0695) (anni 1998-2000). Ricercatore (responsabile di centro) Studio SIFA-II (Studio Italiano Fibrillazione Atriale-II) Ricercatore (responsabile di centro) Studio VantagE study (Efficacy, tolerability, and safety of rivastigmine -Exelon- in probable vascular dementia) Responsabile di centro e responsabile nazionale CADASIL Study (Safety and tolerability of Donepezil in patients with CADASIL who have cognitive impairment) AFFILIAZIONE E BOARD DI SOCIETA’ E ORGANIZZAZIONI SCIENTIFICHE Gruppo di Studio Malattie Cerebrovascolari (afferente alla Società Italiana di Neurologia) quindi denominata Associazione Italiana Ictus-Italian Stroke Association - ISA e quindi Italian Stroke Organization-ISO Dal 1996 al presente. European Task Force on Age-Related White Matter Changes 1996 - 2002 Comitato Scientifico dell’Italian Stroke Forum Network e dal 2011 al 2015 membro del Comitato Direttivo (revisore dei conti). International Society for Vascular Behavioural and Cognitive Disorders (VAS-COG) (membro fondatore). International Psychogeriatric Association (IPA) (dal 2003 al 2011) Board of Directors della International Psychogeriatric Association (IPA) (2003-2007) Rieletto per il quadriennio 2007-2011. Società Italiana di Neurologia (dal 2005)


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Affiliazioni (segue):

Membro dell’Executive Committee dell’International Society for Vascular Behavioural and Cognitive Disorders (2009-2013) Membro del Consiglio Direttivo della Società Italiana di Neurogeriatria (SINEG) (2009-2011, confermato 2012-2014 e 2015-2017) Membro del Comitato Scientifico della Società Italiana per lo Studio delle Demenze (SINDEM) (2012-2015) Membro del Comitato Direttivo della Società Italiana per lo Studio delle Demenze (SINDEM) (dal 2016) Presidente Eletto Società Italiana di Neurogeriatria (SINEG) (2018-19)


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RELAZIONI, SEMINARI E LETTURE AD INVITO (solo internazionali) 1. "Experimental approaches to white matter disease" Roundtable "White matter disease" Amsterdam (Olanda), 28 Maggio 1997, 6th European Stroke Conference

2. "Subcortical vascular dementia: therapeutical approaches"

Conferencia Nacional de Alzheimer Pamplona (Spagna), 7 Novembre 1997

3. “Vascular dementia without strokes”

Swiss Dementia Advisory Board Berna (Svizzera), 23 Giugno 1998

4. "Pathophysiology of subcortical vascular dementia"

Workshop on Subcortical Vascular Dementia 3rd Congress of the European Federation of Neurological Societies Siviglia (Spagna), 22 Settembre 1998

5. "The role of white matter changes in vascular dementia"

3rd International Conference on Harmonization of Dementia Drug Guidelines Osaka (Giappone), 8 Ottobre 1998

6. "Binswanger's disease: one century later"

VIth Lille Neurological Workshop Lille (Francia), 28 Novembre 1998

7. “Subcortical vascular dementia: pathogenic aspects and therapeutic approaches”

Subcortical Vascular Dementia Symposium, Annual Meeting of the Spanish Neurological Society Barcellona (Spagna), 18 Dicembre 1998

8. "White matter diseases" European Seminars on Diagnostic and Interventional Radiology (ESDIR) MRI: Diagnosis, Function and Treatment Copenhagen (Danimarca), 3 Giugno 1999

9. "Should the term subcortical vascular dementia replace the eponym «Binswanger's disease»?" First International Congress on Vascular Dementia Ginevra (Svizzera), 4 Ottobre 1999


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Relazioni, seminari e letture ad invito internazionali (segue) 10. “What is the significance of leukoaraiosis in dementia?”

Joint Meeting of the International Psychogeriatric Association and Royal College of Psychiatrists’ Faculty of Old Age “Non-Alzheimer Cognitive Impairment” Newcastle upon Tyne (UK), 6 Aprile 2000

11. “Age-related white matter changes: clinical, pathological, and pathogenic aspects” University of Göteborg, Institute of Clinical Neuroscience Göteborg (Svezia), 13 Settembre 2000

12. “Pathophysiological and biochemical aspects of vascular dementia”

2nd Paul Janssen Medical Institute and University of Göteborg Postgraduate Course “Alzheimer’s disease and vascular dementia and their interaction” Göteborg (Svezia), 15 Settembre 2000

13. “Pathophysiology of white matter lesions”

The Friedrich Merz Visiting Professorship Symposium at the Deutsche Bibliothek “Small vessel diseases, white matter lesions and vascular cognitive impairment” Francoforte sul Meno (Germania), 14 Febbraio 2001

14. “Small vessel disease: pathophysiology” International Psychogeriatric Association Special Expert Conference Vascular Burden of the Brain – New Therapeutic Directions Madrid (Spagna), 28 Novembre 2001

15. “Vascular cognitive impairment. MRI features” Symposium Vascular Cognitive Impairment – Towards Criteria Second International Congress on Vascular Dementia Salisburgo (Austria), 25 Gennaio 2002

16. “Pathological lesions in vascular dementia” Third World Congress in Vascular Factors in Alzheimer’s Disease Kyoto (Giappone), 8 Aprile 2002

17. “Subcortical vascular dementia: pathophysiology and experimental models”. Symposium “Subcortical vascular dementia: a new disorder?” 11th Congress of the Association of European Psychiatrists Stoccolma (Svezia), 5 Maggio 2002

18. “Vascular dementia – evolving concepts” The Master Class in Dementia St. John’s College

Cambridge (Inghilterra), 15 Settembre 2002


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Relazioni, seminari e letture ad invito internazionali (segue)

19. “Subcortical vascular dementia: pathophysiological aspects” Simposio “Vascular Dementia in Clinical Practice” Firenze (Italia), 14 Ottobre 2002

20. “Subcortical vascular dementia: pathophysiology and experimental models” Simposio “Subcortical vascular dementia: a new disorder?” 30th Congress of the European Association of Geriatric Psychiatry Abano Terme (Italia), 15 Novembre 2002

21. “Small vessel disease and disability in the geriatric population” First National Congress of the Austrian Society of Neurology Innsbruck (Austria), 22 Marzo 2003

22. “Treatment of vascular dementia: evidence from trials with non-cholinergic drugs” 1st Congress of the International Society for Vascular Behavioural and Cognitive Disorders Göteborg (Svezia), 31 Agosto 2003

23. “The Benefits of donepezil in the treatment of vascular dementia” Satellite Symposium “Maximizing the therapeutic benefits in dementia”

7th Congress of the European Federation of Neurological Societies Helsinki (Finlandia), 2 Settembre 2003

24. “Therapeutic perspectives in subcortical vascular disease” Symposium “Subcortical Brain Parenchyma Changes in Vascular Diseases, Multiple Sclerosis and in the Aging Brain - New Insights and Therapeutic Perspectives” Mannheim (Germania), 29 Gennaio 2005 25. “Subcortical vascular dementia: natural history and therapeutic perspectives”

Teaching course “Subcortical vascular dementia” 14th European Stroke Conference Bologna, 25 Maggio 2005

26. “Therapeutic approaches to subcortical vascular dementia” Symposium “Subcortical vascular dementia” 2nd Congress of the International Society for Vascular Behavioural and Cognitive Disorders Firenze, 11 Giugno 2005

27. “New evidence in the field of white matter changes” 2005 Brain Forum Tokyo (Giappone), 16 Settembre 2005


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Relazioni, seminari e letture ad invito internazionali (segue) 28. “Are post-stroke dementia and post-stroke depression possible target for clinical trials?” Simposio “Vascular Cognitive ad Behavioural Disorders” 12th International Congress of the International Psychogeriatric Association Stoccolma (Svezia), 20-24 Settembre 2005 29. “Clinical use of neuroimaging: expectations and problems of the practicing physician” Symposium “Clinical use of neuroimaging” 12th International Congress of the International Psychogeriatric Association Stoccolma (Svezia), 20-24 Settembre 2005 30. “Neuroimaging correlates of vascular cognitive impairment”

Regional meeting of the International Psychogeriatric Association Lisbona (Portogallo), 3-6 Maggio 2006

31. “Vascular cognitive impairment: diagnosis and treatment”

Luigi Amaducci Teaching Course on Dementia 10th Congress of the European Federation of Neurological Societies Glasgow, (Regno Unito), 2 Settembre 2006

32. “Suspecting and diagnosing CADASIL in the clinical setting: usefulness and limitations of applying criteria”

CADASIL symposium Sigtuna (Svezia), 30 Novembre- 1 Dicembre 2006 33. ”Small vessels disease: treatment aspects”

16th European Stroke Conference Glasgow (Regno Unito), 29 Maggio - 1 Giugno 2007

34. “Non-CADASIl familial leuko-encephalopathy” 5th International Congress on Vascular Dementia Budapest (Ungheria), 8-11 Novembre 2007 35. “Leukoaraiosis and disability: the LADIS (leukoaraiosis and disability) study

experience” 5th International Congress on Vascular Dementia Budapest (Ungheria), 8-11 Novembre 2007 36. “Usefulness of CT-scanning in dementia” International Psychogeriatrics Association Neuroimaging in Dementia Workshop

Amsterdam (Olanda), 28 Novembre 2007


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Relazioni, seminari e letture ad invito internazionali (segue) 37. “White matter changes and the transition to disability in the elderly” 2nd Portuguese Stroke Society Congress Cascais (Portogallo), 25 Gennaio 2008 38. “The Burden of Cerebrovascular Diseases in Vascular Cognitive Impairment and Dementia” Vth International Workshop on Ischemic Stroke Madrid (Spagna), 4 Aprile 2008 39. “Usefulness of CT-scanning in dementia” International Psychogeriatrics Association Neuroimaging in Dementia Workshop

Dublino (Irlanda), 8 Aprile 2008

40. “Age-related white matter changes: effects on cognition, mood, gait and disability” XVI Brazilian Congress of Geriatrics and Gerontology Porto Alegre (Brasile), 6 Giugno 2008 41. “The role of cerebrovascular diseases and pathology in cognitive impairment” XVI Brazilian Congress of Geriatrics and Gerontology Porto Alegre (Brasile), 6 Giugno 2008 42. “Usefulness of CT-scanning in dementia” International Psychogeriatrics Association Neuroimaging in Dementia Workshop

Firenze, 11 Novembre 2008 43. “The relationship of white matter lesions with mood and cognition” Raymond Levy lecture, 2009 International Meeting of the International Psychogeriatrics Association Rio de Janeiro (Brasile), 4 Maggio 2009 44. “Sporadic and genetic small vessel disease: mechanisms and pathogenesis” 13th Congress of the European Federation of Neurological Societies. Firenze, 12-15 Settembre 2009 45. “Vascular dementia: diagnosis and treatment”

Luigi Amaducci Teaching Course on Dementia 13th Congress of the European Federation of Neurological Societies. Firenze, 12-15 Settembre 2009 46. “Clinical impact of lesion progression in SVD (longitudinal data) in elderly subjects:

The LADIS Experience” 20th European Stroke Conference

Barcellona (Spagna), 26 Maggio 2010


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47. “Usefulness of CT-scanning in dementia” International Psychogeriatrics Association Neuroimaging in Dementia Workshop

Santiago de Compostela (Spagna), 25 Settembre 2010 48. “The contribution of small vessel disease to cognitive impairment”

Bis 10 Brain Ischemia and Stroke Roma, 8 Ottobre 2010

49. “CADASIL” Congresso Stroke Lombardia 2011 Stroke Registries: epidemiology, quality indicators and process care Milano, 4 Febbraio 2011

50. “Management issues of MCI after stroke” 21st European Stroke Conference Amburgo (Germania), 26 Maggio 2011

51. “2001-2011: what did we learn from the LADIS Study on the role of white matter

lesions and small vessel disease?” 15th European Stroke Organization Summer School Mannheim (Germania), 26 Luglio 2011


IPA 15th International Congress L’Aia (Olanda), 5 Settembre 2011

53. “Neuroimaging examination: CT, MRI, SPECT, PET” The Luigi Amaducci teaching course on dementia 15th Congress of the European Federation of Neurological Societies Budapest (Ungheria), 10 Settembre 2011

54. “The Leukoaraiosis and Disability Study. Top 10 in 10 years - outlook for the future” VAS-COG 2011 Congress Lille (Francia), 14 Settembre 2011

55. “Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges” ANIM 2012 Berlino (Germania), 20 Gennaio 2012


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56. “Clinical Features and Therapeutic Targets in Microvascular Disease” Internation Stroke Conference 2012 New Orleans, Louisiana, (USA), 2 Febbraio 2012

57. “Post-stroke dementia” Teaching course 22nd European Stroke Conference Lisbona (Portogallo), 22 Maggio 2012


Coimbra (Portogallo), 7 Giugno 2012 59. “Update on vascular risk management in dementia “

The Luigi Amaducci teaching course on dementia 16th Congress of the European Federation of Neurological Societies Stoccolma (Svezia), 8 Settembre 2012

60. “Cognitive impairment and dementia after stroke”

22nd European Stroke Conference Londra (UK), 28-31 Maggio 2013

61. “The clinical consequences of white matter changes and cerebral small vessel disease:

insight from the LADIS (Leukoaraiosis and Disability) Study “ VAS-COG Japan 2013 Tokyo (Giappone), 10 Agosto 2013

62. “Small vessel stroke: a benign etiology?” 17th European Stroke Organization Summer School Perugia, 9 Settembre 2013

63. “Update on post-stroke dementia and vascular risk factor modification”

23rd European Stroke Conference Nizza (Francia), 6-9 Maggio 2014

64. “Pathogenic mechanisms of post-stroke cognitive decline and mood disorders. Relevance

of connectivity dysfunction” SIECV-ESC joint Academic Symposium

23rd European Stroke Conference Nizza (Francia), 6-9 Maggio 2014


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65. “Cerebral small vessel disease: what have we learned from the LADIS Study?”

The 10th International Symposium on Geriatrics and Gerontology Nagoya (Giappone), 7 Febbraio 2015

66. “Treating SVD: current standards and novel approaches”

European Stroke Organization conference Glasgow (UK), 17-19 Aprile 2015


Berlino (Germania), 13 Ottobre 2015 68. “Cerebral small vessel disease: from new definition to therapeutic options” Congresso nazionale della Società Spagnola di Neurologia Conferencia Dr. Belarmino Rodriguez Arias Valencia (Spagna), 19 Novembre 2015

69. “Small vessel diseases in the brain”

2016 International Meeting on asthma, COPD and concomitant disorders Modena, 25 Febbraio 2016

70. “How to approach the patient with cerebral SVD: a practical guide” The Second European Stroke Organization Conference Barcellona (Spagna), 11 Maggio 2016 71. “Update on neuropsychiatric complications of stroke” Belgian Stroke Council International Symposium Leuven (Belgio), 3 Dicembre 2016 72. “How to approach the patient with cerebral SVD” 11° congresso nazionale della Società Portoghese di Malattie Cerebrovascolari (AVC) Oporto (Portogallo), 3 Febbraio 2017 73. “Pathophysiology and treatment of the patient with COPD and neurological disorders” 2017 International Meeting on asthma, COPD and concomitant disorders Firenze, 10 Marzo 2017 74. “The Florence-Gothenburg collaboration: a 20-year experience” Anders Wallin symposium Gothenburg (Svezia), 7 Aprile 2017


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Relazioni, seminari e letture ad invito internazionali (segue) 75. “Natural history of white matter disease of ageing” World Stroke Congress Montreal, Canada, 18 Ottobre 2018 76. “Detecting the contribution of small vessel disease to dementia” Congresso nazionale della Società Spagnola di Neurologia Conferencia Thomas-Willis Siviglia, Spagna, 23 Novembre 2018


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PUBBLICAZIONI: Indici bibliometrici

Hirsh Index (HI) = 60 (fonte: Scopus, 15 Novembre 2018)

Hirsh Index (HI) = 55 (fonte: ISI Web of Knowledge, 15 Novembre 2018)

Published Items in Each Year


36

Citations in Each Year


37

Articoli pubblicati su riviste internazionali:

1. Pantoni L, Inzitari D, Colao MG, De Mayo E, Marini P, Mazzotta F. Cytomegalovirus

encephalitis in a non-immunocompromised patient: CSF diagnosis by in situ hybridization

cells. Acta Neurologica Scandinavica 1991;84:56-58.

2. Pantoni L, Inzitari D, Pracucci G, Lolli F, Giordano GP, Bracco L, Amaducci L.

Cerebrospinal fluid proteins in patients with leucoaraiosis: possible abnormalities in

blood-brain barrier function. Journal of the Neurological Sciences 1993;115:125-131.

3. Pantoni L, Inzitari D. Hachinski's Ischemic Score and the diagnosis of vascular

dementia: a review. The Italian Journal of Neurological Sciences 1993;14:539-546.

4. Pantoni L, Garcia JH. The significance of cerebral white matter abnormalities 100 years

after Binswanger's report: a review. Stroke 1995;26:1293-1301.

5. Garcia JH, Pantoni L. Stroke in childhood. Seminars in Pediatric Neurology

1995;2:180-191.

6. Pantoni L, Garcia JH, Brown GG. Vascular pathology in three cases of progressive

cognitive deterioration. Journal of the Neurological Sciences 1996;135:131-139.

7. Pantoni L, Garcia JH. Binswanger's disease: what's in a name? Cerebrovascular

Diseases 1996;6:259-262.

8. Pantoni L, Garcia JH, Gutierrez JA. Cerebral white matter is highly vulnerable to

ischemia. Stroke 1996;27:1641-1647.

9. Pantoni L, Moretti M, Inzitari D. The first Italian report of "Binswanger's disease". The

Italian Journal of Neurological Sciences 1996;17:367-370.

10. Pantoni L, Carosi M, Amigoni S, Mascalchi M, Inzitari D. A preliminary open trial with

nimodipine in patients with cognitive impairment and leukoaraiosis. Clinical

Neuropharmacology 1996;19:497-506.

11. Inzitari D, Cadelo M, Marranci ML, Pracucci G, Pantoni L. Vascular deaths in elderly

neurological patients with leukoaraiosis. Journal of Neurology, Neurosurgery, and

Psychiatry 1997;62:177-181.

12. Pantoni L, Poggesi L, Repice A, Inzitari D. Disappearance of motor tics after Wernicke's

encephalopathy in a patient with Tourette's syndrome. Neurology 1997;48:381-383.

13. Pantoni L, Garcia JH. Pathogenesis of leukoaraiosis: a review. Stroke 1997;28:652-659.

14. Inzitari D, Pantoni L, Lamassa M, Pallanti S, Pracucci G, Marini P. Emotional arousal

and phobia in transient global amnesia. Archives of Neurology 1997;54:866-873.


38

Articoli pubblicati su riviste internazionali (segue):

15. Pantoni L, Garcia JH. Cognitive impairment and cellular/vascular changes in cerebral

white matter. Annals of New York Academy of Sciences 1997;826:92-102.

16. Scheltens P, Erkinjuntti T, Leys D, Wahlund L-O, Inzitari D, del Ser T, Pasquier F,

Barkhof F, Mäntylä R, Bowler J, Wallin A, Ghika J, Fazekas F, Pantoni L. White matter

changes on CT and MRI: an overview of visual rating scales. European Neurology

1998;39:80-89.

17. Pantoni L, Sarti C, Inzitari D. Cytokines and cell adhesion molecules in cerebral

ischemia: experimental bases and therapeutic perspectives. Arteriosclerosis, Thrombosis

and Vascular Biology 1998;18:503-513.

18. Inzitari D, Pantoni L. Subcortical vascular dementia: therapeutical aspects. Archives of

Gerontology and Geriatrics 1998;suppl 6:263-268.

19. Pantoni L. Experimental approaches to white matter disease. Dementia and Geriatric

Cognitive Disorders 1998;9(suppl.1):20-24.

20. Erkinjuntti T, Pantoni L, Scheltens P. Cooperation and networking on white matter

disorders: the European Task Force on Age-Related White Matter Changes. Dementia

and Geriatric Cognitive Disorders 1998;9(suppl.1):44-45.

21. Inzitari D, Pantoni L. Cognitive impairment and cerebrovascular diseases. European

Journal of Neurology 1998;5(suppl 5):S9-S13.

22. Leys D, Englund E, del Ser T, Inzitari D, Fazekas F, Bornstein N, Erkinjuntti T, Bowler J,

Pantoni L, Parnetti L, de Reuck J, Ferro J, Bogousslavsky J, on behalf of the European

Task Force on Age-Related White Matter Changes. White matter changes in stroke

patients. Relationship with stroke subtypes and outcome. European Neurology

1999;42:67-75. [IF 1,379]

23. Melani A, Pantoni L, Corsi C, Bianchi L, Monopoli A, Bertorelli R, Pepeu G, Pedata F.

Striatal outflow of adenosine, excitatory amino acids, -aminobutyric acid, and taurine in

awake freely moving rats following middle cerebral artery occlusion. Correlations with

neurological deficit and histopathological damage. Stroke 1999;30:2448-2455. [IF 5,528]

24. Pantoni L, Leys D, Fazekas F, Longstreth WT Jr., Inzitari D, Wallin A, Filippi M,

Scheltens P, Erkinjuntti T, Hachinski V. The role of white matter lesions in cognitive

impairment of vascular origin. Alzheimer Disease and Associated Disorders

1999;13(suppl.3):S49-S54. [IF 1,229]

25. Inzitari D, Erkinjuntti T, Wallin A, del Ser T, Pantoni L. Is subcortical vascular dementia

a clinical entity for clinical drug trials? Alzheimer Disease and Associated Disorders

1999;13(suppl.3):S66-S68. [IF 1,229]


39


26. Rossi R, Inzitari D, Pantoni L, del Ser T, Erkinjuntti T, Wallin A, Bianchi C, Badenas

JM, Beneke M. Nimodipine in subcortical vascular dementia trial. Alzheimer Disease

and Associated Disorders 1999;13(suppl.3):S159-S165. [IF 1,229]

27. Erkinjuntti T, Bowler JV, DeCarli CS, Fazekas F, Inzitari D, O'Brien JT, Pantoni L,

Rockwood K, Scheltens P, Wahlund L-O, Desmond DW. Imaging of static brain lesions

in vascular dementia: implications for clinical trials. Alzheimer Disease and Associated

Disorders 1999;13(suppl.3):S81-S90. [IF 1,229]

28. Pantoni L, Bianchi C, Beneke M, Inzitari D, Wallin A, Erkinjuntti T. The Scandinavian

Multi-Infarct Dementia Trial: a double-blind, placebo-controlled trial on nimodipine in

multi-infarct dementia. Journal of the Neurological Sciences 2000;175:116-123. [IF

1,678]

29. Pantoni L, Rossi R, Inzitari D, Bianchi C, Beneke M, Erkinjuntti T, Wallin A. Efficacy

and safety of nimodipine in subcortical vascular dementia: a subgroup analysis of the

Scandinavian Multi-Infarct Dementia Trial. Journal of the Neurological Sciences

2000;175:124-134. [IF 1,678]

30. Inzitari D, Erkinjuntti T, Wallin A, del Ser T, Romanelli M, Pantoni L. Subcortical

vascular dementia as a specific target for clinical trials. Annals of the New York Academy

of Sciences 2000;903:510-521. [IF 1,381]

31. Erkinjuntti T, Inzitari D, Pantoni L, Wallin A, Scheltens P, Rockwood K, Desmond DW.

Limitations of clinical criteria for the diagnosis of vascular dementia in clinical trials: is

subcortical vascular dementia a solution? Annals of the New York Academy of Sciences

2000;903:262-272. [IF 1,381]

32. Erkinjuntti T, Inzitari D, Pantoni L, Wallin A, Scheltens P, Rockwood K, Roman GC,

Chui H, Desmond DW. Research criteria for subcortical vascular dementia in clinical

trials. Journal of Neural Transmission Supplement 2000;59:23-30. [IF 2,106]

33. Inzitari D, Carlucci G, Pantoni L. White matter changes: the clinical consequences in the

aging population. Journal of Neural Transmission Supplement 2000;59:1-8. [IF 2,106]

34. Pantoni L, Lamassa M, Inzitari D. Transient global amnesia: a review emphasizing

pathogenic aspects. Acta Neurologica Scandinavica 2000;102:275-283. [IF 1,304]

35. Pantoni L, Sarti C, Pracucci G, Di Carlo A, Vanni P, Inzitari D, for the Italian

Longitudinal Study on Aging. Lipoprotein(a) serum levels and vascular diseases in an

older Caucasian population cohort. Journal of the American Geriatrics Society

2001;49:117-125. [IF 2,878]


40


36. Wahlund LO, Barkhof F, Fazekas F, Bronge L, Augustin M, Sjögren M, Wallin A, Ader

H, Leys D, Pantoni L, Pasquier F, Erkinjuntti T, Scheltens P. A new rating scale for age-

related white matter changes applicable to MRI and CT. Stroke 2001;32:1318-1322. [IF

5,330]

37. Sarti S, Pantoni L, Pracucci G, Di Carlo A, Vanni P, Inzitari D, for the Italian

Longitudinal Study on Aging. Lipoprotein(a) and cognitive performances in an elderly

white population: cross-sectional and follow-up data. Stroke 2001;32:1678-1683. [IF

5,330]

38. Di Carlo A, Perna AM, Pantoni L, Basile AM, Bonacchi M, Pracucci G, Trefoloni G,

Bracco L, Sangiovanni V, Piccini C, Palmarini MF, Carbonetto F, Biondi E, Sani G,

Inzitari D. Clinically relevant cognitive impairment after cardiac surgery: a 6-month

follow-up study. Journal of the Neurological Sciences 2001;188:85-93. [IF 1,986]

39. Pantoni L, Basile AM, Romanelli M, Piccini C, Sarti C, Nencini P, Inzitari D. Abulia

and cognitive impairment in two patients with capsular genu infarct. Acta Neurologica

Scandinavia 2001;104:185-190. [IF 1,064]

40. Fazekas F, Barkhof F, Wahlund LO, Pantoni L, Erkinjuntti T, Scheltens P, Schmidt R.

CT and MRI rating of white matter lesions. Cerebrovascular Diseases 2002;13 (Suppl.

2):31-36. [IF 1,852]

41. Sarti C, Pantoni L, Bartolini L, Inzitari D. Cognitive impairment and chronic cerebral

hypoperfusion: what can be learned from experimental models. Journal of the

Neurological Sciences 2002;203-204:263-266.

42. Pantoni L. Pathophysiology of age-related cerebral white matter changes.

Cerebrovascular Diseases 2002;13 (Suppl. 2):7-10. [IF 1,852]

43. Sarti C, Pantoni L, Bartolini L, Inzitari D. Persistent impairment of gait performances

and working memory after bilateral common carotid artery occlusion in the adult Wistar

rat. Behavioural Brain Research 2002;136:13-20. [IF 2,791]

44. Mascalchi M, Moretti M, Della Nave R, Lolli F, Tessa C, Carlucci G, Bartolini L,

Pracucci G, Pantoni L, Filippi M, Inzitari D. Longitudinal evaluation of leukoaraiosis

with whole brain ADC histograms. Neurology 2002;59:939-940. [IF 5,340]

45. Román GC, Erkinjuntti T, Wallin A, Pantoni L, Chui HC. Subcortical ischaemic vascular

dementia. Lancet Neurology 2002;1:426-436. [IF 3,070]

46. Pantoni L, Simoni M, Pracucci G, Schmidt R, Barkhof F, Inzitari D. Visual rating scales

for age-related white matter changes (leukoaraiosis): can the heterogeneity be reduced?

Stroke 2002;33:2827-2833. [IF 5,176]


41


47. Pantoni L, Palumbo V, Sarti C. Pathological lesions in vascular dementia. Annals of the

New York Academy of Sciences 2002;977:279-291. [IF 1,682]

48. Melani A, Pantoni L, Bordoni F, Gianfriddo M, Bianchi L, Vannucchi MG, Bertorelli R,

Monopoli A, Pedata F. The selective A2A receptor antagonist SCH 58261 reduces striatal

transmitter outflow, turning behavior and ischemic brain damage induced by permanent

focal ischemia in the rat. Brain Research 2003;959:243-250. [IF 2,474]

49. O’Brien JT, Erkinjuntti T, Reisberg B, Roman R, Sawada T, Pantoni L, Bowler JV,

Ballard C, DeCarli C, Gorelick PB, Rockwood K, Burns A, Gauthier S, DeKosky ST.

Vascular cognitive impairment. Lancet Neurology 2003;2:89-98. [IF 3,070]

50. Pantoni L. Not-so-silent infarcts. Lancet Neurology 2003;2:335. [IF 3,070]

51. Wallin A, Milos V, Sjögren M, Pantoni L, Erkinjuntti T. Classification and subtypes of

vascular dementia. International Psychogeriatrics 2003;15(suppl.1):27-37. [IF 1,577]

52. Pantoni L, Simoni M. Pathophysiology of cerebral small vessels in vascular cognitive

impairment. International Psychogeriatrics 2003;15(suppl.1):59-65. [IF 1,577]

53. Schmidt R, Scheltens P, Erkinjuntti T, Pantoni L, Markus HS, Wallin A, Barkhof F,

Fazekas F, for the European Task Force on Age-Related White Matter Changes. White

matter lesion progression. A surrogate endpoint for trials in cerebral small vessel disease.

Neurology 2004;63:139-144. [IF 5,973]

54. Inzitari D, Lamassa M, Pantoni L, Basile AM. Therapy of vascular dementias. Archives

of Gerontology and Geriatriacs 2004;38(Suppl):229-234. [IF 0,556]

55. Pantoni L, Sarti C, Pescini F, Bianchi S, Bartolini L, Nencini P, Basile AM, Lamassa M,

Kalaria RN, Dotti MT, Federico A, Inzitari D. Thrombophilic risk factors and unusual

clinical features in three Italian CADASIL patients. European Journal of Neurology

2004;11:782-787. [IF 2,225]

56. Pantoni L. Treatment of vascular dementia: evidence from trials with non-cholinergic

drugs. Journal of the Neurological Sciences 2004;226:67-70. [IF 2,366]

57. Pantoni L, Basile AM, Pracucci G, Asplund K, Bogousslavsky J, Chabriat H, Erkinjuntti

T, Fazekas F, Ferro JM, Hennerici M, O'Brien J, Scheltens P, Visser MC, Wahlund L-O,

Waldemar G, Wallin A, Inzitari D, on behalf of the LADIS Study Group. Impact of age-

related cerebral white matter changes on the transition to disability. The LADIS

(Leukoaraiosis And DISability in the elderly) Study: rationale, design and methodology.

Neuroepidemiology 2005;24:51-62. [IF 2,602]

58. Pantoni L, Bertini E, Lamassa M, Pracucci G, Inzitari D. Clinical features, risk factors, and

prognosis in transient global amnesia: a follow-up study. European Journal of Neurology

2005;12:350-356. [IF 2,244]


42


59. Dotti MT, Federico A, Mazzei R, Bianchi S, Scali O, Conforti FL, Sprovieri T, Guidetti

D, Aguglia U, Consoli D, Pantoni L, Sarti C, Inzitari D, Quattrone A. The spectrum of

NOTCH3 mutations in 28 Italian CADASIL families. Journal of Neurology,

Neurosurgery and Psychiatry 2005;76:736-738. [IF 3,122]

60. Pantoni L, Del Ser T, Soglian AG, Amigoni S, Spadari G, Binelli D, Inzitari D. Efficacy

and safety of nimodipine in subcortical vascular dementia: a randomized placebo-

controlled trial. Stroke 2005;36:619-624. [IF 5,855]

61. van der Flier WM, van Straaten ECW, Barkhof F, Ferro JM, Pantoni L, Basile AM,

Inzitari D, Erkinjuntti T, Wahlund LO, Rostrup E, Schmidt R, Fazekas F, Scheltens P, on

behalf of the LADIS study group. Medial temporal lobe atrophy and white matter

hyperintensities are associated with mild cognitive deficits in non-disabled elderly: the

LADIS study. Journal of Neurology, Neurosurgery and Psychiatry 2005;76:1497-1500.

[IF 3,122]

62. Firback MJ, O’Brien JT, Pakrasi S, Pantoni L, Simoni M, Erkinjuntti T, Wallin A,

Wahlund L-O, van Strateen I, Inzitari D, on behalf of the LADIS group. White matter

hyperinyensities and depression. Preliminary results from the LADIS study. International

Journal of Geriatric Psychiatry 2005;20:674-679. [IF 2,160]

63. van der Flier WM, van Straaten ECW, Barkhof F, Verdello A, Madureira S, Pantoni L,

Inzitari D, Erkinjuntti T, Crisby M, Waldemar G, Schmidt R, Fazekas F, Scheltens P, on

behalf of the LADIS study group. Small vessel disease and general cognitive function in

non-disabled elderly: the LADIS study. Stroke 2005;36:2116-2120. [IF 5,855]

64. Pescini F, Sarti C, Pantoni L, Mangiafico S, Bianchi S, Dotti MT, Federico A, Inzitari D.

Cerebellar arteriovenous malformation and vertebral artery aneurysm in a CADASIL

patient. Acta Neurologica Scandinavica 2006;113:62-63. [IF 1,833]

65. Basile AM, Pantoni L, Pracucci G, Asplund K, Chabriat H, Erkinjuntti T, Fazekas F,

Ferro JM, Hennerici M, O'Brien J, Scheltens P, Visser MC, Wahlund L-O, Waldemar G,

Wallin A, Inzitari D, on behalf of the LADIS Study Group. Age, hypertension, and

lacunar stroke are the major determinants of the severity of age-related white matter

changes. The LADIS (Leukoaraiosis And DISability in the elderly) Study.

Cerebrovascular Diseases 2006;21:315-322. [IF 2,003]

66. van Straaten ECW, Fazekas F, Rostrup E, Scheltens P, Schmidt R, Pantoni L, Inzitari D,

Waldemar G, Erkinjuntti T, Mantyla R, Wahlund L-O, Barkhof F, on behalf of the LADIS

study group. Impact of white matter hyperintensities scoring method on correlations with

clinical data: the LADIS study. Stroke 2006;37:836-840. [IF 5,391]

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Pescini+F%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Sarti+C%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Pantoni+L%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Mangiafico+S%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Bianchi+S%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Dotti+MT%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Federico+A%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Inzitari+D%22%5BAuthor%5D


43


67. Pantoni L, Sarti C, Alafuzoff I, Jellinger K, Munoz DG, Ogata J, Palumbo V.

Postmortem examination of vascular lesions in cognitive impairment. A survey among

neuropathological services. Stroke 2006;37:1005-1009. [IF 5,391]

68. Pantoni L. New evidence in the field of white matter changes [Articolo in Giapponese].

No To Shinkei 2006;58:298-302.

69. Prati P, Casaroli M, Bignamini A, Scotti S, Canciani L, Ruscio M, Balestrieri M,

Bornstein N, Zanetti O, Tosetto A, Castellani S, Pantoni L, Touboul PJ, Inzitari D.

Cognitive Impairment and Carotid Atherosclerosis in a General Italian Midlife and Old

Population. Neuroepidemiology 2006;27:33-38. [IF 2,352]

70. Pantoni L, Poggesi A, Basile AM, Pracucci G, Barkhof F, Chabriat H, Erkinjuntti T,

Ferro JM, Hennerici M, O'Brien JT, Schmidt R, Visser MC, Wahlund L-O, Waldemar G,

Wallin A, Inzitari D on behalf of the LADIS Study Group. Leukoaraiosis predicts hidden

global functioning impairment in nondisabled elderly. The LADIS (Leukoaraiosis and

Disability in the Elderly) Study. Journal of the American Geriatrics Society

2006;54:1095-1101. [IF 3,331]

71. Guo X, Pantoni L, Simoni M, Gustafson D, Bengtsson C, Palmertz B, Skoog I. Midlife

respiratory function related to white matter lesions and lacunar infarcts in late life: The

Prospective Population Study of Women in Gothenburg, Sweden. Stroke 2006;37:1658-

1662. [IF 5,391]

72. Pantoni L. White matter ischemia: time to begin integrating experimental and clinical

data. European Neurology 2006;56:71-73. [IF 1,031]

73. Madureira S, Verdelho A, Ferro J, Basile AM, Chabriat H, Erkinjuntti T, Fazekas F,

Hennerici M, O’Brien J, Pantoni L, Salvadori E, Scheltens P, Visser MC, Wahlund L-O,

Waldemar G, Wallin A, Inzitari D on behalf of the LADIS Study. Development of a

neuropsychological battery for a multinational study: the LADIS (Leukoaraiosis And

DISability): experience and baseline data. Neuroepidemiology 2006;27:101-116. [IF

2,352]

74. Krishnan MS, O’Brien JT, Firbank MJ, Pantoni L, Carlucci G, Erkinjuntti T, Wallin A,

Wahlund L-O, Scheltens P, van Straaten ECW, Inzitari D,on behalf of the LADIS group.

Relationship between periventricular and deep white matter lesions and depressive

symptoms in older people. The LADIS Study. International Journal of Geriatric

Psychiatry 2006;21:983-989. [IF 1,930]

75. O’Brien JT, Firbank MJ, Krishnan MS, van Straaten ECW, van de Flier W, Petrovic K,

Pantoni L, Simoni M, Erkinjuntti T, Wallin A, Wahlund L-O, Inzitari D on behalf of the

LADIS group.White matter hyperintensities rather than lacunar infacts are associated with

depressive symptoms in older people. The LADIS study. American Journal of Geriatric

Psychiatry 2006;14:834-841. [IF 2,894]


http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Sarti+C%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Alafuzoff+I%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Jellinger+K%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Munoz+DG%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Ogata+J%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Palumbo+V%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Prati+P%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Casaroli+M%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Bignamini+A%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Scotti+S%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Canciani+L%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Ruscio+M%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Balestrieri+M%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Bornstein+N%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Zanetti+O%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Tosetto+A%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Castellani+S%22%5BAuthor%5D


http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Touboul+PJ%22%5BAuthor%5D

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Search&itool=pubmed_Abstract&term=%22Inzitari+D%22%5BAuthor%5D


44


76. Gouw AA, van der Flier WM, van Straaten ECW, Barkhof F, Ferro JM, Baezner H.

Pantoni L, Inzitari D, Erkinjuntti T, Wahlund L-O, Waldemar G, Schmidt R, Fazekas F,

Scheltens P on behalf of the LADIS study group. Simple versus complex assessment of

white matter hyperintensities in relation to gait and cognition in non-disabled elderly,

experience within the LADIS study. Journal of Neurology 2006; 253:1189-1196. [IF

2,984]

76. Ryberg C, Rostrup E, Stegmann MB, Barkhof F, Scheltens P, van Straaten ECW,

Fazekas F, Schmidt R, Ferro JM, Baezner H, Erkinjuntti T, Jokinen H, Wahlund L-O,

O’Brien J, Basile AM, Pantoni L, Inzitari D, Waldemar G, on behalf of the LADIS

study group. Clinical significance of corpus callosum atrophy in a mixed elderly

population. Neurobiology of Aging 2007;28:955-963. [IF 5,607]

77. Jokinen H, Ryberg C, Kalska H, Ylikoski R, Rostrup E, Stegmann MB, Waldemar G,

Madureira S, Ferro JM, van Straaten EC, Scheltens P, Barkhof F, Fazekas F, Schmidt R,

Carlucci G, Pantoni L, Inzitari D, Erkinjuntti T. Corpus callosum atrophy is associated

with mental slowing and executive deficits in subjects with age-related white matter

hyperintensities. The LADIS study. Journal of Neurology, Neurosurgery and Psychiatry

2007;78:491-496. [IF 3,857]

78. Inzitari D, Simoni M, Pracucci G, Poggesi A, Basile AM, Chabriat H, Erkinjuntti T,

Fazekas F, Ferro JM, Hennerici M, Langhorne P, O'Brien J, Barkhof F, Visser MC,

Wahlund LO, Waldemar G, Wallin A, Pantoni L; LADIS Study Group. Risk of rapid

global functional decline in elderly patients with severe cerebral age-related white matter

changes: the LADIS study. Archives of Internal Medicine 2007;167:81-88. [IF 8,391]

79. Korf ES, van Straaten EC, de Leeuw FE, van der Flier WM, Barkhof F, Pantoni L,

Basile AM, Inzitari D, Erkinjuntti T, Wahlund LO, Rostrup E, Schmidt R, Fazekas F,

Scheltens P; LADIS Study Group. Diabetes mellitus, hypertension and medial temporal

lobe atrophy: the LADIS study. Diabetic Medicine 2007;24:166-171. [IF 2,970]

80. Ylikoski R, Jokinen H, Andersen P, Salonen O, Madureira S, Ferro J, Barkhof F, van der

Flier W, Schmidt R, Fazekas F, Scheltens P, Waldemar G, Salvadori E, Pantoni L,

Inzitari D, Erkinjuntti T. Comparison of the Alzheimer's Disease Assessment Scale

Cognitive Subscale and the Vascular Dementia Assessment Scale in Differentiating

Elderly Individuals with Different Degrees of White Matter Changes. The LADIS Study.

Dementia and Geriatric Cognitive Disorders 2007;24:73-81. [IF 2,641]

81. Pantoni L, Poggesi A, Inzitari D. The relation between white matter lesions and

cognition. Current Opinion in Neurology 2007;20:390-397. [IF 5,550]

82. Pescini F, Bianchi S, Dotti MT, Federico A, Inzitari D, Pantoni L. First report of a

Romanian CADASIL patient following immigration to Italy. European Journal of

Neurology, 2007;14:e7-8. [IF 2,580]

http://www.unifi.it/LADIS/publicationform.php?idp=16

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http://www.ncbi.nlm.nih.gov/sites/entrez?Db=pubmed&Cmd=ShowDetailView&TermToSearch=17210882&ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum










45


83. Teodorczuk A, O'Brien JT, Firbank MJ, Pantoni L, Poggesi A, Erkinjuntti T, Wallin A,

Wahlund LO, Gouw A, Waldemar G, Schmidt R, Ferro JM, Chabriat H, Bazner H,

Inzitari D; the LADIS Group. White matter changes and late-life depressive symptoms:

longitudinal study. British Journal of Psychiatry 2007;191:212-217. [IF 5,446]

84. Verdelho A, Madureira S, Ferro JM, Basile AM, Chabriat HC, Erkinjuntti T, Fazekas F,

Hennerici MM, O'brien J, Pantoni L, Salvadori E, Scheltens P, Visser MC, Wahlund

LO, Gunhild Waldemar G, Wallin A, Inzitari D. Differential impact of cerebral white

matter changes, diabetes, hypertension and stroke on cognitive performance among non

disabled elderly. The LADIS study. Journal of Neurology Neurosurgery and Psychiatry

2007;78:1325-1330. [IF 3,857]

85. Frisoni GB, Galluzzi S, Pantoni L, Filippi M. The effect on cognition of white matter

lesions in the elderly: small but detectable. Nature Clinical Practice Neurology

2007;3:620-627. [IF 4,339]

86. Sjöstrand K, Rostrup E, Ryberg C, Larsen R, Studholme C, Baezner H, Ferro J, Fazekas

F, Pantoni L, Inzitari D, Waldemar G; LADIS Study Group. Sparse decomposition and

modeling of anatomical shape variation. IEEE Transaction Medical Imaging

2007;26:1625-1635. [IF 3,275]

87. Gouw AA, van der Flier WM, van Straaten EC, Pantoni L, Bastos-Leite AJ, Inzitari D,

Erkinjuntti T, Wahlund LO, Ryberg C, Schmidt R, Fazekas F, Scheltens P, Barkhof F.

Reliability and sensitivity of visual scales versus volumetry for evaluating white matter

hyperintensity progression. Cerebrovascular Diseases 2008;25:247-253. [IF 3,041]

88. Pescini F, Bianchi S, Salvadori E, Poggesi A, Dotti MT, Federico A, Inzitari D, Pantoni

L. A pathogenic mutation on exon 21 of the NOTCH3 gene causing CADASIL in an

octogenarian paucisymptomatic patient. Journal of the Neurological Sciences

2008;267:170-173. [IF 2,359]

89. Baezner H, Blahak C, Poggesi A, Pantoni L, Inzitari D, Chabriat H, Erkinjuntti T,

Fazekas F, Ferro JM, Langhorne P, O'Brien J, Scheltens P, Visser MC, Wahlund L-O,

Waldemar G, Wallin A, Hennerici MG, on behalf of the LADIS Study Group.

Association of gait and balance disorders with age-related white matter changes -the

LADIS study. Neurology 2008;70:935-942. [IF 7,043]

90. Pantoni L. Leukoaraiosis: from an ancient term to an actual marker of poor

prognosis (invited editorial). Stroke 2008;39:1401-1403. [IF 6,499]

91. Guo X, Skoog I, Idrizbegovic E, Pantoni L, Simoni M, Rosenhall U. Hearing loss and

cortical atrophy in a population-based study on non-demented women. Age Ageing

2008;37:333-336. [IF 3,052]









http://www.ncbi.nlm.nih.gov/pubmed/18216467?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum




46


92. Dyrby TB, Rostrup E, Baaré WF, van Straaten EC, Barkhof F, Vrenken H, Ropele S,

Schmidt R, Erkinjuntti T, Wahlund LO, Pantoni L, Inzitari D, Paulson OB, Hansen LK,

Waldemar G; on behalf of the LADIS study group. Segmentation of age-related white

matter changes in a clinical multi-center study. Neuroimage 2008;41:335-345. [IF

5,694]

93. Gouw AA, van der Flier WM, Fazekas F, van Straaten EC, Pantoni L, Poggesi A,

Inzitari D, Erkinjuntti T, Wahlund LO, Waldemar G, Schmidt R, Scheltens P, Barkhof F;

on behalf of the LADIS Study Group. Progression of white matter hyperintensities and

incidence of new lacunes over a 3-year period. The Leukoaraiosis and Disability Study.

Stroke 2008;39:1414-1420. [IF 3,052]

94. Miranda B, Madureira S, Verdelho A, Ferro JM, Pantoni L, Salvadori E, Chabriat H,

Erkinjuntti T, Fazekas F, Hennerici M, O'Brien J, Scheltens P, Visser MC, Wahlund LO,

Waldemar G, Wallin A, Inzitari D. Self-perceived memory impairment and cognitive

performance in an elderly independent population with age-related white matter changes.

Journal of Neurology Neurosurgery and Psychiatry 2008;79:869-873. [IF 4,622]

95. Poggesi A, Pracucci G, Chabriat H, Erkinjuntti T, Fazekas F, Verdelho A, Hennerici M,

Langhorne P, O'Brien J, Scheltens P, Visser MC, Crisby M, Waldemar G, Wallin A,

Inzitari D, Pantoni L, on behalf of the LADIS Study Group. Urinary complaints in Non-

Disabled Elders With Age-Related White Matter Changes: the LADIS Study. Journal of

the American Geriatrics Society 2008;56:1638-1643. [IF 3,805]

96. Galluzzi S, Lanni C, Pantoni L, Filippi M, Frisoni GB. White matter lesions in the

elderly: pathophysiological hypothesis on the effect on brain plasticity and reserve.

Journal of the Neurological Sciences 2008;273:3-9. [IF 2,359]

97. Valenti R, Poggesi A, Pescini F, Inzitari D, Pantoni L. Psychiatric disturbances in

CADASIL: a brief review. Acta Neurologica Scandinavica 2008;118:291-295. [IF 2,317

98. Simoni M, Pantoni L, Pracucci G, Palmertz B, Guo X, Gustafson D, Skoog I.

Prevalence of CT-detected cerebral abnormalities in an elderly Swedish population

sample. Acta Neurologica Scandinavica 2008;118:260-267. [IF 2,317]

99. Ryberg C, Rostrup E, Sjöstrand K, Paulson OB, Barkhof F, Scheltens P, van Straaten

ECW, Fazekas F, Schmidt R, Erkinjuntti T, Wahlund L-O, Basile AM, Pantoni L,

Inzitari D, Waldemar G, on behalf of the LADIS study group. White matter changes

contribute to corpus callosum atrophy in the elderly: The LADIS study. AJNR American

Journal of Neuroradiology 2008; 29:1498-1504. [IF 2,745]

100. Gouw AA, van der Flier WM, Pantoni L, Inzitari D, Erkinjuntti T, Wahlund LO,

Waldemar G, Schmidt R, Fazekas F, Scheltens P, Barkhof F, on behalf of the LADIS

study group. On the etiology of incident brain lacunes: longitudinal observations

from the LADIS study. Stroke 2008;39:3083-3085. [IF 6,499]











47


101. Stromillo ML, Dotti MT, Battaglini M, Mortilla M, Bianchi S, Plewnia K, Pantoni L,

Inzitari D, Federico A, De Stefano N. Structural and Metabolic Brain Abnormalities in

Preclinical CADASIL. Journal of Neurology Neurosurgery and Psychiatry 2009;80:41-

47. [IF 4,622]

102. Jokinen H, Kalska H, Ylikoski R, Madureira S, Verdelho A, Gouw A, Scheltens P,

Barkhof F, Visser MC, Fazekas F, Schmidt R, O'Brien J, Hennerici M, Baezner H,

Waldemar G, Wallin A, Chabriat H, Pantoni L, Inzitari D, Erkinjuntti T. MRI-Defined

Subcortical Ischemic Vascular Disease: Baseline Clinical and Neuropsychological

Findings. The LADIS Study. Cerebrovascular Diseases 2009;27:336-344. [IF 3,041]

103. Ropele S, Seewann A, Gouw AA, van der Flier WM, Schmidt R, Pantoni L, Inzitari D,

Erkinjuntti T, Scheltens P, Wahlund LO, Waldemar G, Chabriat H, Ferro J, Hennerici M,

O'Brien J, Wallin A, Langhorne P, Visser MC, Barkhof F, Fazekas F; LADIS study

group. Quantitation of brain tissue changes associated with white matter hyperintensities

by diffusion-weighted and magnetization transfer imaging: the LADIS (Leukoaraiosis

and Disability in the Elderly) study. Journal of Magnetic Resonance Imaging

2009;29:268-274. [IF 2,658]

104. Zipoli V, Hakiki B, Portaccio E, Lolli F, Siracusa G, Giannini M, Pantoni L, Pescini F,

Sorbi S, Amato M. The contribution of cerebrospinal fluid oligoclonal bands to the early

diagnosis of multiple sclerosis. Multiple Sclerosis 2009;15:472-478. [IF 3,312]

105. Nannucci S, Pescini F¸ Poggesi A, Ciolli L, Patrosso MC, Marocchi A, Inzitari D, Penco

S, Pantoni L. Familial cerebral cavernous malformation: report of a further Italian

family. Neurological Sciences 2009;30:143-147. [IF 1,435]

106. Jokinen H, Kalska H, Ylikoski R, Madureira S, Verdelho A, van der Flier WM, Scheltens

P, Barkhof F, Visser MC, Fazekas F, Schmidt R, O'Brien J, Waldemar G, Wallin A,

Chabriat H, Pantoni L, Inzitari D, Erkinjuntti T; LADIS group. Longitudinal cognitive

decline in subcortical ischemic vascular disease--the LADIS Study. Cerebrovascular

Diseases 2009;27:384-391. [IF 3,041]

107. Pantoni L, Poggesi A, Inzitari D. Cognitive decline and dementia related to

cerebrovascular diseases: some evidence and concepts. Cerebrovascular Diseases

2009;27(Suppl. 1):191-196. [IF 3,041]

108. Benisty S, Gouw AA, Porcher R, Madureira S, Hernandez K, Poggesi A, van der Flier

WM, Van Straaten EC, Verdelho A, Ferro J, Pantoni L, Inzitari D, Barkhof F, Fazekas

F, Chabriat H. Location of lacunar infarcts correlates with cognition in a sample of non

disabled subjects with age-related white matter changes: the LADIS study. Journal of

Neurology Neurosurgery and Psychiatry 2009;80:478-483. [IF 4,622]

http://www.ncbi.nlm.nih.gov/pubmed/18829627?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

















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109. Blahak C, Baezner H, Pantoni L, Poggesi A, Chabriat H, Erkinjuntti T, Fazekas F, Ferro

JM, Langhorne P, O'Brien J, Visser MC, Wahlund LO, Waldemar G, Wallin A, Inzitari

D, Hennerici MG. Deep frontal and periventricular age-related white matter changes but

not basal ganglia and infratentorial hyperintensities are associated with falls - cross-

sectional results from the LADIS study. Journal of Neurology Neurosurgery and

Psychiatry 2009;80:608-613. [IF 4,622]

110. Inzitari D, Pracucci G, Poggesi A, Carlucci G, Barkhof F, Chabriat H, Erkinjuntti T,

Fazekas F, Ferro JM, Hennerici M, Langhorne P, O'Brien J, Scheltens P, Visser MC,

Wahlund LO, Waldemar G, Wallin A, Pantoni L for the LADIS Study Group. Changes

in white matter as determinant of global functional decline in older independent

outpatients: three year follow-up of LADIS (leukoaraiosis and disability) study cohort.

BMJ 2009 Jul 6;339:b2477. doi: 10.1136/bmj.b2477 [IF 12,827]

111. Guo X, Pantoni L, Simoni M, Bengtsson C, Björkelund C, Lissner L, Gustafson D,

Skoog I. Blood Pressure Components and Changes in Relation to White Matter Lesions:

A 32-year Prospective Population Study of Women. Hypertension 2009;54.57-62. [IF

7,368]

112. Saia V, Pantoni L. Progressive stroke in pontine infarction. Acta Neurologica

Scandinavica 2009;120:213-215. [IF 2,317]

113. Pantoni L. Should memory clinic physicians be independent in assessing neuroimaging

of patients with cognitive impairment? Aging Clinical and Experimental Research

2009;21:264-265. [IF 1,397]

114. Pantoni L, Pescini F, Nannucci S, Sarti C, Bianchi S, Dotti MT, Federico A, Inzitari D.

Comparison of clinical, familial, and MRI features of CADASIL and NOTCH3 negative

patients. Neurology 2010;74:57-63. [IF 7,043]

115. Pescini F, Cesari F, Giusti B, Sarti C, Zicari E, Bianchi S, Dotti MT, Federico A,

Balestrino M, Enrico A, Gandolfo C, Gori AM, Abbate R, Pantoni L, Inzitari D. Bone

Marrow-Derived Progenitor Cells in Cerebral Autosomal Dominant Arteriopathy With

Subcortical Infarcts and Leukoencephalopathy. Stroke 2010;41:218-223. [IF 6,499]

116. Teodorczuk A, Firbank MJ, Pantoni L, Poggesi A, Erkinjuntti T, Wallin A, Wahlund

LO, Scheltens P, Waldemar G, Schrotter G, Ferro JM, Chabriat H, Bazner H, Visser M,

Inzitari D, O'Brien JT. Relationship between baseline white-matter changes and

development of late-life depressive symptoms: 3-year results from the LADIS study.

Psychological Medicine 2010;40:603-610. [IF 4,212]

117. Madureira S, Verdelho A, Moleiro C, Ferro JM, Erkinjuntti T, Jokinen H, Pantoni L,

Fazekas F, Van der Flier W, Visser M, Waldemar G, Wallin A, Hennerici M, Inzitari D.

Neuropsychological Predictors of Dementia in a Three-Year Follow-Up Period: Data

from the LADIS Study. Dementia and Geriatric Cognitive Disorders 2010;29:325-334.

[IF 3,142]








http://www.ncbi.nlm.nih.gov/pubmed/19959913?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2







http://www.ncbi.nlm.nih.gov/pubmed/20389074



49


118. Bianchi S, Rufa A, Ragno M, D'Eramo C, Pescini F, Pantoni L, Cappelli A, Perretti A,

Zicari E, Zolo P, Inzitari D, Dotti MT, Federico A. High frequency of exon 10 mutations

in the NOTCH3 gene in Italian CADASIL families: phenotypic peculiarities. Journal of

Neurology 2010;257:1039-1042. [IF 2,536]

119. Schmidt R, Ropele S, Ferro J, Madureira S, Verdelho A, Petrovic K, Gouw A, van der

Flier WM, Enzinger C, Pantoni L, Inzitari D, Erkinjuntti T, Scheltens P, Wahlund LO,

Waldemar G, Rostrup E, Wallin A, Barkhof F, Fazekas F; on behalf of the LADIS study

group. Diffusion-Weighted Imaging and Cognition in the Leukoariosis and Disability in

the Elderly Study. Stroke 2010;41:e402-408. [IF 6,499]

120. Jonsson M, Zetterberg H, van Straaten E, Lind K, Syversen S, Edman Å, Blennow K,

Rosengren L, Pantoni L, Inzitari D, Wallin A. Cerebrospinal fluid biomarkers of white

matter lesions – cross-sectional results from the LADIS study. European Journal of

Neurology 2010;17:377-382. [IF 2,732]

121. Verdelho A, Madureira S, Moleiro C, Ferro JM, Santos CO, Erkinjuntti T, Pantoni L,

Fazekas F, Visser M, Waldemar G, Wallin A, Hennerici M, Inzitari D. White matter

changes and diabetes predict cognitive decline in the elderly: the LADIS study.

Neurology 2010;75:160-167. [IF 7,043]

122. Pantoni L. Cerebral small vessel diseases: a reappraisal of nosology, pathogenesis,

neuroimaging, clinical correlates, and therapeutic issues [invited review]. Lancet

Neurology 2010; 9:689-701. [IF 14,270]

123. Olesen PJ, Gustafson DR, Simoni M, Pantoni L, Ostling S, Guo X, Skoog I. Temporal

lobe atrophy and white matter lesions are related to major depression over 5 years in the

elderly. Neuropsychopharmacology 2010; 35:2638-2645.

124. Pantoni L, Gorelick P. Advances in vascular cognitive impairment 2010. Stroke

2011;42:291-293.

125. Jokinen H, Gouw AA, Madureira S, Ylikoski R, van Straaten EC, van der Flier WM,

Barkhof F, Scheltens P, Fazekas F, Schmidt R, Verdelho A, Ferro JM, Pantoni L,

Inzitari D, Erkinjuntti T; On behalf of the LADIS Study Group. Incident lacunes

influence cognitive decline: The LADIS study. Neurology 2011;76:1872-1878.

126. Valenti R, Pescini F, Antonini S, Castellini G, Poggesi A, Bianchi S, Inzitari D, Pallanti

S, Pantoni L. Major depression and bipolar disorders in CADASIL: a study using the

DSM-IV semi-structured interview. Acta Neurologica Scandinavica 2011;124:390-395.

127. Valenti R, Bianchi S, Pescini F, D’Eramo C, Inzitari D, Dotti MT, Pantoni L. First

report of a pathogenic mutation on exon 24 of the NOTCH3 gene in a CADASIL family.

Journal of Neurology 2011;258:1632-1636.









50


128. Ryberg C, Rostrup E, Paulson OB, Barkhof F, Scheltens P, van Straaten EC, van der

Flier WM, Fazekas F, Schmidt R, Ferro JM, Baezner H, Erkinjuntti T, Jokinen H,

Wahlund LO, Poggesi A, Pantoni L, Inzitari D, Waldemar G; on behalf of the LADIS

study group. Corpus callosum atrophy as a predictor of age-related cognitive and motor

impairment: A 3-year follow-up of the LADIS study cohort. Journal of the Neurological

Sciences 2011;307:100-105.

129. Schmidt R, Schmidt H, Haybaeck J, Loitfelder M, Weis S, Cavalieri M, Seiler S,

Enzinger C, Ropele S, Erkinjuntti T, Pantoni L, Scheltens P, Fazekas F, Jellinger K.

Heterogeneity in age-related white matter changes. Acta Neuropathologica

2011;122:171-185.

130. Pasi M, Poggesi A, Pantoni L. The use of CT in dementia. International

Psychogeriatrics 2011;23 (Suppl. 2):S6–S12.

131. Verdelho A, Madureira S, Moleiro C, Santos CO, Ferro JM, Erkinjuntti T, Poggesi A,

Pantoni L, Fazekas F, Scheltens P, Waldemar G, Wallin A, Inzitari D. Self-Perceived

Memory Complaints Predict Progression to Alzheimer Disease. The LADIS Study.

Journal of Alzheimer’s Disease 2011;27:491-498.

132. The LADIS Study Group. 2001-2011: a decade of the LADIS (Leukoaraiosis And

DISability) Study: what have we learned about white matter changes and small vessel

disease? Cerebrovascular Diseases 2011;32: 577–588.

133. Frederiksen KS, Garde E, Skimminge A, Barkhof F, Scheltens P, van Straaten EC,

Fazekas F, Baezner H, Verdelho A, Ferro JM, Erkinjuntti T, Jokinen H, Wahlund LO,

O'Brien JT, Basile AM, Pantoni L, Inzitari D, Waldemar G. Corpus Callosum Tissue

Loss and Development of Motor and Global Cognitive Impairment: The LADIS Study.

Dementia and Geriatric Cognitive Disorders 2011;32:279-286.

134. Campolo J, De Maria R, Frontali M, Taroni F, Inzitari D, Federico A, Romano S, Puca E,

Mariotti C, Tomasello C, Pantoni L, Pescini F, Dotti MT, Stromillo ML, De Stefano N,

Tavani A, Parodi O. Impaired vasoreactivity in mildly disabled CADASIL patients.

Journal of Neurology, Neurosurgery and Psychiatry 2012; 83:268-274.

135. Johansson L, Skoog I, Gustafson DR, Olesen PJ, Waern M, Bengtsson C, Björkelund C,

Pantoni L, Simoni M, Lissner L, Guo X. Midlife psychological distress associated with

late-life brain atrophy and white matter lesions: a 32-year population study of women.

Psychosomatic Medicine 2012;74:120-125.

136. Rostrup E, Gouw AA, Vrenken H, van Straaten EC, Ropele S, Pantoni L, Inzitari D,

Barkhof F, Waldemar G; on behalf of the LADIS study group. The spatial distribution of

age-related white matter changes as a function of vascular risk factors-Results from the

LADIS study. Neuroimage 2012;60:1597-1607.











51


137. Donnini I, Pescini F, Nannucci S, Valenti R, Bianchi S, Inzitari D, Pantoni L.

Acetazolamide for the prophylaxis of migraine in CADASIL: a preliminary experience.

The Journal of Headache and Pain 2012;13:299-302.

138. Jokinen H, Lipsanen J, Schmidt R, Fazekas F, Gouw AA, van der Flier WM, Barkhof F,

Madureira S, Verdelho A, Ferro JM, Wallin A, Pantoni L, Inzitari D, Erkinjuntti T.

Brain atrophy accelerates cognitive decline in cerebral small vessel disease. The LADIS

study. Neurology 2012;78:1785-1792.

139. Firbank MJ, Teodorczuk A, van der Flier WM, Gouw AA, Wallin A, Erkinjuntti T,

Inzitari D, Wahlund LO, Pantoni L, Poggesi A, Pracucci G, Langhorne P, O'Brien JT;

the LADIS group. Relationship between progression of brain white matter changes and

late-life depression: 3-year results from the LADIS study. British Journal of Psychiatry

2012;201:40-45.

140. Jokinen H, Frederiksen KS, Garde E, Skimminge A, Siebner H, Waldemar G,Ylikoski

R, Madureira S, Verdelho A, van Straaten EC, Barkhof F, Fazekas F,Schmidt R, Pantoni

L, Inzitari D, Erkinjuntti T. Callosal tissue loss parallels subtle decline in psychomotor

speed. a longitudinal quantitative MRI study. The LADIS Study. Neuropsychologia

2012;50:1650-1655.

141. Jonsson M, Zetterberg H, Rolstad S, Edman A, Gouw AA, Bjerke M, Lind K, Blennow

K, Pantoni L, Inzitari D, Wallin A. Low Cerebrospinal Fluid Sulfatide Predicts

Progression of White Matter Lesions - The LADIS Study. Dementia and Geriatric

Cognitive Disorders 2012;34:61-67.

142. Schmidt R, Berghold A, Jokinen H, Gouw AA, van der Flier WM, Barkhof F,

Scheltens P, Petrovic K, Madureira S, Verdelho A, Ferro JM, Waldemar G, Wallin A,

Wahlund LO, Poggesi A, Pantoni L, Inzitari D, Fazekas F, Erkinjuntti T; on behalf

of the LADIS Study Group. White Matter Lesion Progression in LADIS: Frequency,

Clinical Effects, and Sample Size Calculations. Stroke 2012;43:2643-2647.

143. Pescini F, Nannucci S, Bertaccini B, Salvadori E, Bianchi S, Ragno M, Sarti C, Valenti

R, Zicari E, Moretti M, Chiti S, Stromillo ML, De Stefano N, Dotti MT, Federico A,

Inzitari D, Pantoni L. The Cerebral Autosomal-Dominant Arteriopathy With Subcortical

Infarcts and Leukoencephalopathy (CADASIL) Scale: A Screening Tool to Select

Patients for NOTCH3 Gene Analysis. Stroke 2012;43:2871-2876.

144. Verdelho A, Madureira S, Ferro JM, Baezner H, Blahak C, Poggesi A, Hennerici

M, Pantoni L, Fazekas F, Scheltens P, Waldemar G, Wallin A, Erkinjuntti T,

Inzitari D; on behalf of the LADIS Study. Physical Activity Prevents Progression

for Cognitive Impairment and Vascular Dementia: Results From the LADIS

(Leukoaraiosis and Disability) Study. Stroke 2012;43:3331-3335.


52


145. Consoli A, Pasi M, Pantoni L. Vascular mild cognitive impairment: concept, definition,

and directions for future studies. Aging, Clinical and Experimental Research

2012;24:113-116.

146. Ciolli L, Poggesi A, Salvadori E, Valenti R, Nannucci S, Pasi M, Pescini F, Inzitari D,

Pantoni L. The VAS-COG clinic: an out-patient service for patients with cognitive and

behavioral consequences of cerebrovascular diseases. Neurological Sciences

2012;33:1277-1283.

147. Poggesi A, Salvadori E, Pantoni L, Pracucci G, Cesari F, Chiti A, Ciolli L, Cosottini M,

Del Bene A, De Stefano N, Diciotti S, Dotti MT, Ginestroni A, Giusti B, Gori AM,

Nannucci S, Orlandi G, Pescini F, Valenti R, Abbate R, Federico A, Mascalchi M, Murri

L, Inzitari D. Risk and determinants of dementia in patients with mild cognitive

impairment and brain subcortical vascular changes: a study of clinical, neuroimaging,

and biological markers - The VMCI-Tuscany study: rationale, design, and methodology.

International Journal of Alzheimer’s Disease 2012:608013. doi:10.1155/2012/608013.

Epub 2012 Apr 8.

148. Valenti R, Salvadori E, Pescini F, Poggesi A, Castellini G, Antonini S, Bianchi S, Inzitari

D, Pallanti S, Pantoni L. Facial affect recognition in CADASIL patients. Archives of

Clinical Neuropsychology 2013;28:65-71.

149. Gorelick PB, Pantoni L. Advances in vascular cognitive impairment. Stroke

2013;44:307-308.

150. Poggesi A, Gouw A, van der Flier W, Pracucci G, Chabriat H, Erkinjuntti T, Fazekas F,

Ferro JM, Hennerici M, Langhorne P, O'Brien JT, Visser MC, Wahlund L-O, Waldemar

G, Wallin A, Scheltens P, Inzitari D, Pantoni L, on behalf of the LADIS Study Group.

Cerebral White Matter Changes are associated with Abnormalities on Neurological

Examination in Non-Disabled Elderly: the LADIS study. Journal of Neurology

2013;260:1014-1021.

151. Pasi M, Salvadori E, Poggesi A, Inzitari D, Pantoni L. Factors predicting the Montreal

cognitive assessment (MoCA) applicability and performances in a stroke unit. Journal of

Neurology 2013; 260:1518-1526.

152. Jokinen H, Schmidt R, Ropele S, Fazekas F, Gouw AA, Barkhof F, Scheltens P,

Madureira S, Verdelho A, Ferro JM, Wallin A, Pantoni L, Inzitari D, Erkinjuntti T on

behalf of the LADIS study group. Microstructural changes in normal-appearing brain

tissue predict 3-year cognitive and functional outcome in the LADIS Study. Annals of

Neurology 2013;73:576-583.


53


153. Moleiro C, Madureira S, Verdelho A, Ferro JM, Poggesi A, Chabriat H, Erkinjuntti T,

Fazekas F, Hennerici M, O’Brien J, Pantoni L, Salvadori E, Scheltens P, Visser MC,

Wahlund L-O, Waldemar G, Wallin A, Inzitari D, on behalf of the LADIS group.

Confirmatory factor analysis of the neuropsychological assessment battery of the LADIS

Study: a longitudinal analysis. Journal of Clinical and Experimental Neuropsychology

2013;35:269-278.

154. Rinnoci V, Nannucci S, Valenti R, Donnini I, Bianchi S, Pescini F, Dotti MT, Federico

A, Inzitari D, Pantoni L. Cerebral hemorrhages in CADASIL: report of four cases and a

brief review. Journal of the Neurological Sciences 2013;330:45-51.

155. Wardlaw JM, Smith EE, Biessels GJ, Cordonnier C, Fazekas F, Frayne R, Lindley RI,

O'Brien JT, Barkhof F, Benavente OR, Black SE, Brayne C, Breteler M, Chabriat H,

Decarli C, de Leeuw FE, Doubal F, Duering M, Fox NC, Greenberg S, Hachinski V,

Kilimann I, Mok V, Oostenbrugge Rv, Pantoni L, Speck O, Stephan BC, Teipel S,

Viswanathan A, Werring D, Chen C, Smith C, van Buchem M, Norrving B, Gorelick PB,

Dichgans M; STandards for ReportIng Vascular changes on nEuroimaging (STRIVE v1).

Neuroimaging standards for research into small vessel disease and its contribution to

ageing and neurodegeneration. Lancet Neurology 2013;12:822-838.

156. Kreisel SH, Blahak C, Bäzner H, Inzitari D, Pantoni L, Poggesi A, Chabriat H,

Erkinjuntti T, Fazekas F, Ferro JM, Langhorne P, O'Brien J, Scheltens P, Visser MC,

Wahlund LO, Waldemar G, Wallin A, Hennerici MG. Deterioration of gait and balance

over time: the effects of age-related white matter change - The LADIS Study.

Cerebrovascular Diseases 2013;35:544-553.

157. Verdelho A, Madureira S, Moleiro C, Ferro JM, O'Brien JT, Poggesi A, Pantoni L,

Fazekas F, Scheltens P, Waldemar G, Wallin A, Erkinjuntti T, Inzitari D; on behalf of the

LADIS Study. Depressive symptoms predict cognitive decline and dementia in older

people independently of cerebral white matter changes: the LADIS study. Journal of

Neurology Neurosurgery and Psychiatry 2013;84:1250-1254.

158. Salvadori E, Pasi M, Poggesi A, Chiti G, Inzitari D, Pantoni L. Predictive value of

MoCA in the acute phase of stroke on the diagnosis of mid-term cognitive impairment.

Journal of Neurology 2013; 260:2220-2227.

159. Mascalchi M, Ginestroni A, Toschi N, Poggesi A, Cecchi P, Salvadori E, Tessa C,

Cosottini M, Stefano ND, Pracucci G, Pantoni L, Inzitari D, Diciotti S; VMCI Tuscany

investigators. The burden of microstructural damage modulates cortical activation in

elderly subjects with MCI and leuko-araiosis. A DTI and fMRI study. Human Brain

Mapping 2014;35:819-830.

160. Pantoni L, Fierini F, Poggesi A. Thrombolysis in acute stroke patients with cerebral

small vessel disease. Cerebrovascular Diseases 2014;37:5-13.


54


161. Poggesi A, Gouw A, van der Flier W, Pracucci G, Chabriat H, Erkinjuntti T, Fazekas F,

Ferro JM, Blahak C, Langhorne P, O'Brien J, Schmidt R, Visser MC, Wahlund LO,

Waldemar G, Wallin A, Scheltens P, Inzitari D, Pantoni L. Neurological abnormalities

predict disability: the LADIS (Leukoaraiosis And DISability) study. Journal of

Neurology 2014;261:1160-1169.

162. Ciolli L, Pescini F, Salvadori E, Del Bene A, Pracucci G, Poggesi A, Nannucci S, Valenti

R, Basile AM, Squarzanti F, Bianchi S, Dotti MT, Adriano E, Balestrino M, Federico A,

Gandolfo C, Inzitari D, Pantoni L. Influence of vascular risk factors and

neuropsychological profile on functional performances in CADASIL: results from the

MIcrovascular LEukoencephalopathy Study (MILES). European Journal of Neurology

2014;21:65-71.

163. Opherk C, Gonik M, Duering M, Malik R, Jouvent E, Hervé D, Adib-Samii P, Bevan S,

Pianese L, Silvestri S, Dotti MT, De Stefano N, Liem M, Boon EM, Pescini F, Pachai C,

Bracoud L, Müller-Myhsok B, Meitinger T, Rost N, Pantoni L, Lesnik Oberstein S,

Federico A, Ragno M, Markus HS, Tournier-Lasserve E, Rosand J, Chabriat H, Dichgans

M. Genome-wide genotyping demonstrates a polygenic risk score associated with white

matter hyperintensity volume in CADASIL. Stroke 2014;45:968-972.

164. Pasi M, Nappini S, Salvadori E, Mangiafico S, Limbucci N, Pantoni L. Rapidly

progressive cognitive impairment in a patient with high flow dural arteriovenous fistulas,

cerebral sinus thrombosis and protein S deficiency. Journal of Clinical Neurosciences

2014 ;21:1654-1656.

165. Chiti G, Pantoni L. Use of Montreal Cognitive Assessment in patients with stroke.

Stroke 2014; 45:3135-3140.

166. De Maria R, Campolo J, Frontali M, Taroni F, Federico A, Inzitari D, Tavani A, Romano

S, Puca E, Orzi F, Francia A, Mariotti C, Tomasello C, Dotti MT, Stromillo ML,

Pantoni L, Pescini F, Valenti R, Pelucchi C, Parolini M, Parodi O. Effects of sapropterin

on endothelium-dependent vasodilation in patients with CADASIL: a randomized

controlled trial. Stroke 2014;45:2959-2966.

167. Poggesi A, Salvadori E, Valenti R, Nannucci S, Ciolli L, Pescini F, Pasi M, Fierini F,

Donnini I, Marini S, Chiti G, Rinnoci V, Inzitari D, Pantoni L. The Florence VAS-COG

Clinic: A Model for the Care of Patients with Cognitive and Behavioral Disturbances

Consequent to Cerebrovascular Diseases. Journal of Alzheimers Disease 2014;42:S453–

S461.

168. Marini S, Caruso A, Falcini M, Palumbo P, Pantoni L. Listeria monocytogenes

brainstem infection (rhombencephalitis) mimicking ischemic stroke. Journal of Clinical

Neurosciences 2014;21:2006-2008.








55


169. Nannucci S, Donnini I, Pantoni L. Inherited leukoencephalopathies with clinical onset in

middle and old age. Journal of the Neurological Sciences 2014;347:1-13.

170. Valenti R, Pantoni L, Markus HS. Treatment of vascular risk factors in patients with a

diagnosis of Alzheimer's disease: a systematic review. BMC Medicine 2014 Nov

11;12(1):160. doi: 10.1186/s12916-014-0160-z.

171. Bjerke M, Jonsson M, Nordlund A, Eckerström C, Blennow K, Zetterberg H, Pantoni L,

Inzitari D, Schmidt R, Wallin A. Cerebrovascular biomarker profile is related to white

matter disease and ventricular dilation in a LADIS substudy. Dementia and Geriatric

Cognitived Disorders Extra 2014;4:385-394.

172. Gislason TB, Ostling S, Börjesson-Hanson A, Sjögren M, Simoni M, Pantoni L, Skoog

I. Effect of diagnostic criteria on prevalence of frontotemporal dementia in the elderly.

Alzheimer’s & Dementia 2015;11:425-433.

173. Nannucci S, Pescini F, Bertaccini B, Bianchi S, Ciolli L, Valenti R, Dotti MT, Federico

A, Inzitari D, Pantoni L. Clinical, familial, and neuroimaging features of CADASIL-like

patients. Acta Neurologica Scandinavica 2015;131:30-36.

174. Salvadori E, Poggesi A, Pracucci G, Inzitari D, Pantoni L. Development and

psychometric properties of a neuropsychological battery for mild cognitive impairment

with small vessel disease: the VMCI-Tuscany Study. Journal of Alzheimers Disease

2015;43:1313-1323.

175. Bianchi S, Zicari E, Carluccio A, Di Donato I, Pescini F, Nannucci S, Valenti R, Ragno

M, Inzitari D, Pantoni L, Federico A, Dotti MT. CADASIL in central Italy: a

retrospective clinical and genetic study in 229 patients. Journal of Neurology

2015;262:134-141.

176. Pasi M, Salvadori E, Poggesi A, Ciolli L, Del Bene A, Marini S, Nannucci S, Pescini F,

Valenti R, Ginestroni A, Toschi N, Diciotti S, Mascalchi M, Inzitari D, Pantoni L, for

the VMCI study. White matter microstructural damage in SVD is associated with MoCA

but not with MMSE performances: VMCI-Tuscany Study. Stroke 2015;46:262-264.

177. Frederiksen KS, Verdelho A, Madureira S, Bäzner H, O'Brien JT, Fazekas F, Scheltens

P, Schmidt R, Wallin A, Wahlund LO, Erkinjunttii T, Poggesi A, Pantoni L, Inzitari D,

Waldemar G; on behalf of the LADIS Study. Physical activity in the elderly is associated

with improved executive function and processing speed: the LADIS Study. International

Journal of Geriatric Psychiatry 2015;30:744-750.

178. Bersano A, Zuffardi O, Pantoni L, Quaglini S, Ciccone R, Vetro A, Persico A, Denaro

MF, Micieli G, on behalf of SVE-LA project collaborators. Next generation sequencing

for systematic assessment of genetic factors of small vessel disease: SVE-LA project.

Journal of Stroke and Cerebrovascular Diseases 2015;24:759-765..




56


179. Valenti R, Salvadori E, Poggesi A, Ciolli L, Pescini F, Nannucci S, Inzitari D, Pantoni

L. Mild cognitive impairment etiologic subtyping using pragmatic and conventional

criteria: preliminary experience in the Florence VAS-COG clinic. Aging Clinical and

Experimental Research 2015;27:345-350.

180. Del Bene A, Ciolli L, Borgheresi L, Poggesi A, Inzitari D, Pantoni L. Is type 2 diabetes

related to leukoaraiosis? An updated review. Acta Neurologica Scandinavica

2015;132:147-155 .

181. Gudmundsson P, Olesen PJ, Simoni M, Pantoni L, Östling S, Kern S, Guo X, Skoog I.

White matter lesions and temporal lobe atrophy related to incidence of both dementia and

major depression in 70-year-olds followed over 10 years. European Journal of

Neurology 2015;22:781-788.

182. Fierini F, Barilaro A, Giambene B, Carlucci G, Grandi V, Maio V, Pantoni L.

Moyamoya in a patient with Sneddon's syndrome. Clinical Neurology and Neurosurgery

2015;129:34-36.

183. Poggesi A, Inzitari D, Pantoni L. Atrial fibrillation and cognition: epidemiological data

and possible mechanisms. Stroke 2015;46:3316-3321.

184. Diciotti S, Ciulli S, Ginestroni A, Salvadori E, Poggesi A, Pantoni L, Inzitari D,

Mascalchi M, Toschi N. Multimodal MRI classification in vascular mild cognitive

impairment. Conference Proceedings IEEE Enginiring Medical Biological Society

2015;2015:4278-4281.

185. Pantoni L, Fierini F, Poggesi A; LADIS Study Group. Impact of cerebral white matter

changes on functionality in older adults: An overview of the LADIS Study results and

future directions. Geriatrics and Gerontology International 2015;15(Suppl 1):10-16.

186. Sakurai T, Tomimoto H, Pantoni L. A new horizon of cerebral white matter

hyperintensity in geriatric medicine. Geriatrics and Gerontology International

2015;15(Suppl. 1) :1-2.

187. Jokinen H, Gonçalves N, Vigário R, Lipsanen J, Fazekas F, Schmidt R, Barkhof F,

Madureira S, Verdelho A, Inzitari D, Pantoni L, Erkinjuntti T; LADIS Study Group.

Early-stage white matter lesions detected by multispectral MRI segmentation predict

progressive cognitive decline. Frontiers in Neuroscience 2015 Dec 2;9:455. doi:

10.3389/fnins.2015.00455. eCollection 2015. PubMed PMID: 26696814; PubMed

Central PMCID: PMC4667087.

188. Charidimou A, Pantoni L, Love S. The concept of sporadic cerebral small vessel

disease: A road map on key definitions and current concepts. International Journal of

Stroke 2016;11:6-18.


57


189. Salvadori E, Poggesi A, Valenti R, Pracucci G, Pescini F, Pasi M, Nannucci S, Marini S,

Del Bene A, Ciolli L, Ginestroni A, Diciotti S, Orlandi G, Di Donato I, De Stefano N,

Cosottini M, Chiti A, Federico A, Dotti MT, Bonuccelli U, Inzitari D, Pantoni L;

VMCI-Tuscany Study Group. Operationalizing mild cognitive impairment criteria in

small vessel disease: the VMCI-Tuscany Study. Alzheimer’s & Dementia 2016;12:407-

418.

190. Poggesi A, Pasi M, Pescini F, Pantoni L, Inzitari D. Circulating biologic markers of

endothelial dysfunction in cerebral small vessel disease: a review. Journal of Cerebral

Blood Flow and Metabolism 2016;36:72-94.

191. Gesierich B, Opherk C, Rosand J, Gonik M, Malik R, Jouvent E, Hervé D, Adib-Samii P,

Bevan S, Pianese L, Silvestri S, Dotti MT, De Stefano N, van der Grond J, Boon EM,

Pescini F, Rost N, Pantoni L, Lesnik Oberstein SA, Federico A, Ragno M, Markus HS,

Tournier-Lasserve E, Chabriat H, Dichgans M, Duering M, Ewers M. APOE ɛ2 is

associated with white matter hyperintensity volume in CADASIL. Journal of Cerebral

Blood Flow and Metabolism 2016;36:199-203.

192. Pasi M, Poggesi A, Salvadori E, Diciotti S, Ciolli L, Del Bene A, Marini S, Nannucci S,

Pescini F, Valenti R, Ginestroni A, Toschi N, Mascalchi M, Inzitari D, Pantoni L. White

matter microstructural damage and depressive symptoms in patients with mild cognitive

impairment and cerebral small vessel disease: the VMCI-Tuscany Study. International

Journal of Geriatric Psychiatry 2016;31:611-618.

193. Pasi M, van Uden IW, Tuladhar AM, de Leeuw FE, Pantoni L. White matter

microstructural damage on diffusion tensor imaging in cerebral small vessel disease:

clinical consequences. Stroke 2016;47:1679-1684.

194. Pantoni L. The relevance of assessing cognitive performances in patients with

cerebrovascular diseases. Journal of the American Medical Directors Association

2016;17:458-459.

195. De Guio F, Jouvent E, Biessels GJ, Black SE, Brayne C, Chen C, Cordonnier C, De

Leeuw FE, Dichgans M, Doubal F, Duering M, Dufouil C, Duzel E, Fazekas F,

Hachinski V, Ikram MA, Linn J, Matthews PM, Mazoyer B, Mok V, Norrving B,

O'Brien JT, Pantoni L, Ropele S, Sachdev P, Schmidt R, Seshadri S, Smith EE, Sposato

LA, Stephan B, Swartz RH, Tzourio C, van Buchem M, van der Lugt A, van

Oostenbrugge R, Vernooij MW, Viswanathan A, Werring D, Wollenweber F, Wardlaw

JM, Chabriat H. Reproducibility and variability of quantitative magnetic resonance

imaging markers in cerebral small vessel disease. Journal of Cerebral Blood Flow and

Metabolism 2016;36:1319-1337.

196. Ciulli S, Citi L, Salvadori E, Valenti R, Poggesi A, Inzitari D, Mascalchi M, Toschi N,

Pantoni L, Diciotti S. Prediction of impaired performance in Trail Making Test in MCI

patients with small vessel disease using DTI data. IEEE Journal of Biomedical and

Health Informatics 2016;20:1026-1033.


58


197. Salvadori E, Poggesi A, Valenti R, Della Rocca E, Diciotti S, Mascalchi M, Inzitari D,

Pantoni L. The rehabilitation of attention in patients with mild cognitive impairment and

brain subcortical vascular changes using the Attention Process Training-II. The RehAtt

Study: rationale, design and methodology. Neurological Sciences 2016;37:1653-1662.

198. METACOHORTS Consortium. METACOHORTS for the study of vascular disease and

its contribution to cognitive decline and neurodegeneration: An initiative of the Joint

Programme for Neurodegenerative Disease Research. Alzheimers & Dementia

2016;12:1235-1249.

199. Charidimou A, Pasi M, Fiorelli M, Shams S, von Kummer R, Pantoni L, Rost N.

Leukoaraiosis, Cerebral hemorrhage, and outcome after intravenous thrombolysis for

acute ischemic stroke: a meta-analysis (v1). Stroke 2016;47:2364-2372.

200. Valenti R, Del Bene A, Poggesi A, Ginestroni A, Salvadori E, Pracucci G, Ciolli L,

Marini S, Nannucci S, Pasi M, Pescini F, Diciotti S, Orlandi G, Cosottini M, Chiti A,

Mascalchi M, Bonuccelli U, Inzitari D, Pantoni L; VMCI-Tuscany Study Group..

Cerebral microbleeds in patients with mild cognitive impairment and small vessel

disease: The Vascular Mild Cognitive Impairment (VMCI)-Tuscany study. Journal of the

Neurological Sciences 2016;368:195-202.

201. Jokinen H, Melkas S, Madureira S, Verdelho A, Ferro JM, Fazekas F, Schmidt R,

Scheltens P, Barkhof F, Wardlaw JM, Inzitari D, Pantoni L, Erkinjuntti T. Cognitive

reserve moderates long-term cognitive and functional outcome in cerebral small vessel

disease. Journal of Neurology, Neurosurgery and Psychiatry 2016;87:1296-1302.

202. Diciotti S, Orsolini S, Salvadori E, Giorgio A, Toschi N, Ciulli S, Ginestroni A, Poggesi

A, De Stefano N, Pantoni L, Inzitari D, Mascalchi M; VMCI Tuscany investigators.

Resting state fMRI regional homogeneity correlates with cognition measures in

subcortical vascular cognitive impairment. Journal of the Neurological Sciences

2017;373:1-6.

203. Valenti R, Charidimou A, Xiong L, Boulouis G, Fotiadis P, Ayres A, Riley G, Kuijf HJ,

Reijmer YD, Pantoni L, Gurol ME, Davidsdottir S, Greenberg SM, Viswanathan A.

Visuospatial functioning in cerebral amyloid angiopathy: a pilot study. Journal of

Alzheimers Disease 2017;56:1223-1227.

204. Paciaroni M, Pantoni L. Thrombolysis in dementia patients with acute stroke: is it

justified? Neurological Sciences 2017;38:27-31.

205. Mascalchi M, Pantoni L, Giannelli M, Valenti R, Bianchi A, Pracucci G, Orsolini S,

Ciulli S, Tessa C, Poggesi A, Pescini F, Inzitari D, Diciotti S. Diffusion tensor imaging

to map brain microstructural changes in CADASIL. Journal of Neuroimaging.

2017;27:85-91.


59


206. Di Donato I, Bianchi S, De Stefano N, Dichgans M, Dotti MT, Duering M, Jouvent E,

Korczyn AD, Lesnik-Oberstein SA, Malandrini A, Markus HS, Pantoni L, Penco S,

Rufa A, Sinanović O, Stojanov D, Federico A. Cerebral Autosomal Dominant

Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) as a model

of small vessel disease: update on clinical, diagnostic, and management aspects. BMC

Medicine 2017;15:41. doi: 10.1186/s12916-017-0778-8.

207. Pescini F, Donnini I, Cesari F, Nannucci S, Valenti R, Rinnoci V, Poggesi A, Gori AM,

Giusti B, Rogolino A, Carluccio A, Bianchi S, Dotti MT, Federico A, Balestrino M,

Adriano E, Abbate R, Inzitari D, Pantoni L. Circulating biomarkers in Cerebral

Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy

patients. Journal of Stroke and Cerebrovascular Diseases 2017;26:823-833.

208. Valenti R, Charidimou A, Xiong L, Boulouis G, Fotiadis P, Ayres A, Riley G, Kuijf HJ,

Reijmer YD, Pantoni L, Gurol ME, Davidsdottir S, Greenberg SM, Viswanathan A.

Visuospatial Functioning in Cerebral Amyloid Angiopathy: A Pilot Study. Journal of

Alzheimers Disease 2017;56:1223-1227.

209. Skrobot OA, O'Brien J, Black S, Chen C, DeCarli C, Erkinjuntti T, Ford GA, Kalaria

RN, Pantoni L, Pasquier F, Roman GC, Wallin A, Sachdev P, Skoog I, Ben-Shlomo

Y, Passmore AP, Love S, Kehoe PG. The vascular impairment of cognition

classification consensus study. Alzheimers & Dementia 2016;13:624-633.

210. Carluccio MA, Di Donato I, Pescini F, Battaglini M, Bianchi S, Valenti R, Nannucci

S, Franci B, Stromillo ML, De Stefano N, Inzitari D, Pantoni L, Nuti R, Federico A,

Gonnelli S, Dotti MT. Vitamin D levels in cerebral autosomal dominant arteriopathy

with subcortical infarcts and leukoencephalopathy (CADASIL). Neurological Sciences

2017;38:1333-1336.

211. Diciotti S, Orsolini S, Salvadori E, Giorgio A, Toschi N, Ciulli S, Ginestroni A,

Poggesi A, De Stefano N, Pantoni L, Inzitari D, Mascalchi M; VMCI Tuscany

investigators. Resting state fMRI regional homogeneity correlates with cognition

measures in subcortical vascular cognitive impairment. Journal of the Neurological

Sciences 2017;373:1-6.

212. Pasi M, Boulouis G, Fotiadis P, Auriel E, Charidimou A, Haley K, Ayres A, Schwab

KM, Goldstein JN, Rosand J, Viswanathan A, Pantoni L, Greenberg SM, Gurol ME.

Distribution of lacunes in cerebral amyloid angiopathy and hypertensive small vessel

disease. Neurology 2017;88:2162-2168.

213. Pantoni L. Have stroke neurologists entered the arena of stroke-related cognitive

dysfunctions? Not yet, but they should! Stroke 2017;48:1441-142.


60


214. Donnini I, Rinnoci V, Nannucci S, Valenti R, Pescini F, Mariani G, Bianchi S, Dotti MT,

Federico A, Inzitari D, Pantoni L. Pregnancy in CADASIL. Acta Neurologica

Scandinavica 2017;136:668-671.

215. Pantoni L. Antipsychotics and Cerebrovascular Accidents: Taking or Not the Risk?

Journal of the American Medical Directors Association 2017;18:651-652.

216. Fierini F, Poggesi A, Pantoni L. Leukoaraiosis as an outcome predictor in the acute and

subacute phases of stroke. Expert Reviews Neurotherapeutics 2017;17:963-975.

217. Pantoni L, Poggesi A, Diciotti S, Valenti R, Orsolini S, Della Rocca E, Inzitari D,

Mascalchi M, Salvadori E. Effect of Attention Training in Mild Cognitive Impairment

Patients with Subcortical Vascular Changes: The RehAtt Study. Journal of Alzheimer’s

Disease 2017;60:615-624.

218. Valenti R, Reijmer YD, Charidimou A, Boulouis G, Martinez SR, Xiong L, Fotiadis P,

Jessel M, Ayres A, Riley G, Pantoni L, Edip Gurol M, Greenberg SM, Viswanathan A.

Total small vessel disease burden and brain network efficiency in cerebral amyloid

angiopathy. Journal of the Neurological Sciences 2017;382:10-12.

219. Skrobot OA, Black SE, Chen C, DeCarli C, Erkinjuntti T, Ford GA, Kalaria RN, O'Brien

J, Pantoni L, Pasquier F, Roman GC, Wallin A, Sachdev P, Skoog I; VICCCS group,

Ben-Shlomo Y, Passmore AP, Love S, Kehoe PG. Progress toward standardized

diagnosis of vascular cognitive impairment: Guidelines from the Vascular Impairment of

Cognition Classification Consensus Study. Alzheimers & Dementia 2018;14:280-292

220. Pasi M, Charidimou A, Boulouis G, Auriel E, Ayres A, Schwab KM, Goldstein JN,

Rosand J, Viswanathan A, Pantoni L, Greenberg SM, Gurol ME. Mixed-location

cerebral hemorrhage/microbleeds: Underlying microangiopathy and recurrence risk.

Neurology 2018;90:e119-e126.

221. Nannucci S, Rinnoci V, Pracucci G, MacKinnon AD, Pescini F, Adib-Samii P, Bianchi

S, Dotti MT, Federico A, Inzitari D, Markus HS, Pantoni L. Location, number and

factors associated with cerebral microbleeds in an Italian-British cohort of CADASIL

patients. PLoS One. 2018 Jan 25;13(1):e0190878.

222. van der Flier WM, Skoog I, Schneider JA, Pantoni L, Mok V, Chen CLH, Scheltens P.

Vascular cognitive impairment. Nature Review Disease Primers 2018 Feb 15;4:18003.

223. Bernhardt J, Zorowitz RD, Becker KJ, Keller E, Saposnik G, Strbian D, Dichgans M,

Woo D, Reeves M, Thrift A, Kidwell CS, Olivot JM, Goyal M, Pierot L, Bennett DA,

Howard G, Ford GA, Goldstein LB, Planas AM, Yenari MA, Greenberg SM, Pantoni L,

Amin-Hanjani S, Tymianski M. Advances in Stroke 2017. Stroke 2018;49:e174-e199.


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224. Salvadori E, Poggesi A, Pracucci G, Chiti A, Ciolli L, Cosottini M, Del Bene A, De

Stefano N, Diciotti S, Di Donato I, Ginestroni A, Marini S, Mascalchi M, Nannucci S,

Orlandi G, Pasi M, Pescini F, Valenti R, Federico A, Dotti MT, Bonuccelli U, Inzitari D,

Pantoni L. Application of the DSM-5 Criteria for Major Neurocognitive Disorder to

Vascular MCI Patients. Dementia and Geriatric Cognitive Disorders Extra 2018;8:104-

116.

225. Piccardi B, Arba F, Nesi M, Palumbo V, Nencini P, Giusti B, Sereni A, Gadda D,

Moretti M, Fainardi E, Mangiafico S, Pracucci G, Nannoni S, Galmozzi F, Fanelli A,

Pezzati P, Vanni S, Grifoni S, Sarti C, Lamassa M, Poggesi A, Pescini F, Pantoni L,

Gori AM, Inzitari D. Reperfusion Injury after ischemic Stroke Study (RISKS): single-

centre (Florence, Italy), prospective observational protocol study. BMJ Open 2018 May

24;8(5):e021183.

226. Lovati C, Giani L, Mariotti D Alessandro C, Tabaee Damavandi P, Mariani C, Pantoni

L. May migraine attack response to triptans be a predictor of the efficacy of

Onabotulinum toxin-A prophylaxis? Neurological Sciences 2018;39(Suppl.1):153-154.

227. Muscogiuri G, Dimaggio L, Giani L, Mariani C, Pantoni L, Lovati C. Personality traits

in migraineurs: a case-control study by personality inventory for DSM-5 (PID-5).

Neurological Sciences 2018;39(Suppl.1):129-130.

228. Corno S, Giani L, Laganà MM, Baglio F, Mariani C, Pantoni L, Lovati C. The brain

effect of the migraine attack: an ASL MRI study of the cerebral perfusion during a

migraine attack. Neurological Sciences 2018 Jun;39(Suppl 1):73-74.

229. Qualtieri A, Ungaro C, Bagalà A, Bianchi S, Pantoni L, Moccia M, Mazzei R. Notch3

protein expression in skin fibroblasts from CADASIL patients. Journal of the

Neurological Sciences 2018;390:121-128.

230. Salvadori E, Dieci F, Caffarra P, Pantoni L. Qualitative Evaluation of the Immediate

Copy of the Rey-Osterrieth Complex Figure: Comparison Between Vascular and

Degenerative MCI Patients. Archives of Clinical Neuropsychology 2018 Feb 6.

doi:10.1093/arclin/acy010. [Epub ahead of print] PubMed PMID: 29420698.

231. Rutten JW, Van Eijsden BJ, Duering M, Jouvent E, Opherk C, Pantoni L, Federico A,

Dichgans M, Markus HS, Chabriat H, Lesnik Oberstein SAJ. The effect of NOTCH3

pathogenic variant position on CADASIL disease severity: NOTCH3 EGFr 1-6

pathogenic variant are associated with a more severe phenotype and lower survival

compared with EGFr 7-34 pathogenic variant. Genetics in Medicine 2018 Jul 22.

doi:10.1038/s41436-018-0088-3. [Epub ahead of print] PubMed PMID: 30032161


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232. Canevelli M, Lacorte E, Cova I, Zaccaria V, Valletta M, Agabiti N, Bruno G, Bargagli

AM, Pomati S, Pantoni L, Vanacore N. Estimating dementia cases in the immigrant

population living in Italy. Neurological Sciences 2018;39:1775-1778..

233. Mascalchi M, Salvadori E, Toschi N, Giannelli M, Orsolini S, Ciulli S, Ginestroni A,

Poggesi A, Giorgio A, Lorenzini F, Pasi M, De Stefano N, Pantoni L, Inzitari D, Diciotti

S; VMCI-Tuscany study group. DTI-derived indexes of brain WM correlate with

cognitive performance in vascular MCI and small-vessel disease. A TBSS study. Brain

Imaging and Behavior 2018 May 9. doi: 10.1007/s11682-018-9873-5. [Epub ahead of

print] PubMed PMID: 29744799.

234. Cova I, Contri P, Pantoni L, Pomati S. Resolution of unilateral upper limb action tremor

after surgical treatment of a contralateral frontoparietal arachnoid cyst. Neurological

Sciences 2018 Sep 19. doi: 10.1007/s10072-018-3559-z. [Epub ahead of print] PubMed

PMID: 30232669.

235. Fierini F, Poggesi A, Salvadori E, Acquafresca M, Fainardi E, Moretti M, Pantoni L.

Cerebral small vessel disease and systemic arteriopathy in intracranial arterial

dolichoectasia patients. Acta Neurologica Scandinavica 2018 Oct 18. doi:

10.1111/ane.13038. [Epub ahead of print] PubMed PMID: 30338521.


63

Articoli pubblicati su riviste italiane:

1. Pantoni L, Inzitari D, Colao MG, De Majo E, Marini P, Mazzotta F. Neuroinfezione da

cytomegalovirus: forme patologiche e mezzi diagnostici a proposito di un caso di

meningoencefalite in soggetto non immunodepresso. Nuova Rivista di Neurologia

1992;2:94-96.

2. Di Carlo AS, Pantoni L, Perna AM, Braconi L, Bonacchi M, Ancona AL, Marinoni M,

Ginanneschi A, Inzitari D. Complicanze neurologiche a seguito di by-pass

cardio-polmonare. Nuova Rivista di Neurologia 1992;2:225-227.

3. Di Carlo AS, Perna AM, Braconi L, Pantoni L, Mascitelli EM, Nannini M, Vaccari G,

Marinoni M, Inzitari D. Complicanze cerebrali a seguito di interventi cardiochirurgici in

circolazione extracorporea. (Revisione critica ed orientamenti attuali). In By Pass

1992;5:429-436.

4. Perna AM, Inzitari D, Bonacchi M, Di Carlo AS, Gentile C, Ginanneschi A, Marinoni M,

Macera-Mascitelli E, Pantoni L, Sabato A, Sangiovanni V, Vaccari G. Il Doppler

transcranico come metodica valutativa del flusso cerebrale in pazienti sottoposti ad

interventi in circolazione extracorporea. Archivio di Chirurgia Toracica e

Cardiovascolare 1994;16:285-292.

5. Inzitari D, Pantoni L. Leucoencefalopatie di origine ischemica. Il Policlinico Sez. Prat.

1995;102:410-412.

6. Pantoni L, Moretti M, Inzitari D. La leucoaraiosi nell'anziano: aspetti clinici e

fisiopatologici. Giornale di Gerontologia 1995;43:407-414.

7. Gensini GF, Simone I, Pantoni L, Inzitari D. I grandi trial nella prevenzione secondaria

dello stroke. Annali Italiani di Medicina Interna 1996;11(suppl 2):102S-109S.

8. Inzitari D, Pantoni L. Le demenze vascolari sottocorticali. Rivista di Neurobiologia

1997;43:499-506.

9. Inzitari D, Romanelli M, Pantoni L. Demenza vascolare sottocorticale: inquadramento

nosografico e indicazioni terapeutiche. Dementia Update 1999;4:24-31.

10. Inzitari D, Pantoni L. Fattori di rischio e terapia della demenza vascolare sottocorticale.

Giornale di Neuropsicofarmacologia 2000;22(suppl.):19-23.

11. Inzitari D, Pantoni L. La leucoencefalopatia vascolare dell’anziano: frequenza e

significato clinico. Giornale di Neuropsicofarmacologia 2000;22:112-114.

12. Inzitari D, Lamassa M, Pantoni L. La demenza vascolare sottocorticale: aspetti

nosografici, diagnostici e terapeutici. Neurological Sciences 2001;22(suppl.):S599-S601.


64

Articoli pubblicati su riviste nazionali (segue):

13. Pantoni L. Demenza vascolare: aspetti clinici e terapeutici. Neurological Sciences

2003;24(suppl.):S607-S609.

14. Pantoni L, Sarti C. Ipoperfusione cerebrale e malattia cerebrovascolare ischemica.

Neurological Sciences 2003;24(suppl.)S771-S773.

15. Inzitari D, Simoni M, Basile AM, Pantoni L. La leucoaraiosi ed il rischio di ictus

cerebrale. Ictus 2004;1: 22-26.

16. Inzitari D, Pescini F, Sarti C, Pantoni L, a nome del Gruppo Italiano CADASIL. Progetti

di ricerca: prospettive per la creazione di un registro italiano della CADASIL.

Neurological Sciences 2004;25:S393-S395.

17. Pantoni L, Di Piero V. La leucoencefalopatia vascolare età-correlata (leucoaraiosi):

proposta per la creazione di un registro nazionale. Neurological Sciences 2004;25:S163-

S166.

18. Magnani E, Pantoni L, Basile AM, Simoni M, Prieto M, Pracucci G, Inzitari D. Disabilità

in una coorte di pazienti anziani europei con leucoaraiosi (lo studio LADIS). Ictus 2005;2:

104-107.

19. Pescini F, Sarti C, Salvadori E, Moretti M, Chiti S, Giordano GP, Bianchi S, Dotti MT,

Federico A, Inzitari D, Pantoni L. Morfologia del corpo calloso nella CADASIL:

possibile influenza sul profilo cognitivo. Rivista Italiana di Neurobiologia 2007;53:247-

254.

20. Pantoni L, Nannucci S, Pescini F, Inzitari D. CADASIL. Ruolo dei fattori di rischio

vascolare e dei deficit della memoria sulla funzionalità. La Neurologia Italiana 2014;3:8-

12.

21. Nannucci S, Donnini I, Pantoni. Leucoencefalopatie ereditarie. Le forme con esordio

clinico in età medio-avanzata. La Neurologia Italiana 2015;2:14-24.


65

Libri editi:

Pantoni L, Inzitari D, Wallin A (Eds). The matter of white matter. Clinical and

pathophysiological aspects of white matter disease related to cognitive decline and vascular

dementia. Utrecht, The Netherlands: Academic Pharmaceutical Productions, 2000 (438

pagine).

Pantoni L, Gorelick P. Cerebral Small Vessel Disease. Cambridge University Press, 2014

(360 pagine)

Libri scritti:

Pantoni L. Ipertensione e deterioramento cognitivo vascolare

Editrice G&G srl, Roma, 2006 (75 pagine).


66

Capitoli di libri:

1. Inzitari D, Marinoni M, Ginanneschi A, Mascalchi M, Pracucci G, Ancona AL, Piccininni

MS, Di Carlo AS, Pantoni L. Pathophysiology of leucoaraiosis. In: Culebras A, Matías

Guiu J, Román G (Eds). New Concepts in Vascular Dementia. Barcelona, Prous Science

Publishers, 1993:103-113.

2. Pantoni L, Garcia JH. Cerebral ischemia and cognitive impairment in the elderly. In :

Bruno A, Chollet F, Vellas BJ, Albarede JL (Eds). Facts and Research in Gerontology

1996. Stroke in the Elderly. Paris: Serdi Publisher 1996:171-182.

3. Garcia JH, Ho K-L, Pantoni L. Pathology. In: Barnett HJM, Mohr JP, Stein BM, Yatsu

FM (Eds). Stroke. Pathophysiology, Diagnosis, and Management (third edition). New

York: Churchill Livingstone, 1998:139-157.

4. Inzitari D, Pantoni L. Do stroke patients with white matter changes have an increased

risk for dementia? In: Leys D, Pasquier F, Scheltens P (Eds). Stroke and Alzheimer's

Disease. The Hague, The Netherlands: Holland Academic Graphics, 1998:141-155.

5. Garcia JH, Pantoni L. Cellular inflammation in experimental ischemic stroke. In: Miller

PL (Ed). Stroke therapy: basic, preclinical, and clinical directions. New York: John

Wiley & Sons, Inc., 1999:271-297.

6. Sarti C, Pantoni L. CADASIL and other hereditary forms of vascular

leukoencephalopathy. In: Pantoni L, Inzitari D, Wallin A (Eds). The matter of white

matter. Clinical and pathophysiological aspects of white matter disease related to

cognitive decline and vascular dementia. Utrecht, The Netherlands: Academic

Pharmaceutical Productions, 2000:335-345.

7. Pantoni L. Cerebral white matter ischemia and anoxia: data from experimental models.

In: Pantoni L, Inzitari D, Wallin A (Eds). The matter of white matter. Clinical and

pathophysiological aspects of white matter disease related to cognitive decline and

vascular dementia. Utrecht, The Netherlands: Academic Pharmaceutical Productions,

2000:377-388.

8. Erkinjuntti T, Pantoni L. Subcortical vascular dementia. In: Gauthier S, Cummings JL

(Eds). Alzheimer’s Disease and Related Disorders Annuals. London, UK: Martin Dunitz

Ltd, 2000:101-133.

9. Inzitari D, Romanelli M, Pantoni L. Leukoaraiosis and cognitive impairment. In: O’Brien

J, Ames D, Burns A (Eds). Dementia, Second edition. London: Edward Arnold

Publishers, 2000:635-653.

10. Pantoni L, Simoni M. The role of white matter lesions in cognitive impairment of

vascular origin. In: Vellas B, Fitten LJ, Winblad B, Feldman H, Grundman M, Giacobini

E (eds). Research and Practice in Alzheimer’s Disease, volume 5. Paris: Serdi Edition,

2001:98-102.


67

Capitoli di libri (segue):

11. Pantoni L, Garcia JH. Ischemic injury to the cerebral white matter: neuropathology of

human and experimental lesions. In: Choi D, Dacey RG, Hsu CY, Powers WJ (eds).

Cerebrovascular Disease: Momentum at the End of the Second Millennium (American

Heart Association Monograph Series). Armonk, New York: Futura Publishing Company,

Inc., 2001:115-129.

12. Pantoni L, Lammie A. Cerebral small vessel disease: pathological and pathophysiological

aspects in relation to vascular cognitive impairment. In: Erkinjuntti T, Gauthier S

(eds).Vascular cognitive impairment. London: Martin Dunitz Ltd., 2002:115-133.

13. Wallin A, Milos V, Sjögren M, Pantoni L, Erkinjuntti T. Classification and subtypes of

vascular dementia. In: Erkinjuntti T, Gauthier S (eds). Vascular cognitive impairment.

London: Martin Dunitz Ltd., 2002:27-42.

14. Pantoni L. Subtypes of vascular dementia and their pathogenesis: a critical overview. In:

Bowler J, Hachinski V (eds). Vascular cognitive impairment: preventable dementia.

Oxford: Oxford University Press, 2003:217-229.

15. Inzitari D, Lamassa M, Pantoni L. Treatment of vascular dementias. In: Bowler J,

Hachinski V (eds). Vascular cognitive impairment: preventable dementia. Oxford: Oxford

University Press, 2003:277-292.

16. Sarti C, Pantoni L. Experimental models of vascular dementia: a focus on white matter

disease and incomplete infarction. In: Bowler J, Hachinski V (eds). Vascular cognitive

impairment: preventable dementia. Oxford: Oxford University Press, 2003:76-92.

17. Pantoni L. The role of white-matter lesions in dementia. In: Gauthier S, Scheltens P,

Cummings JL (eds). Alzheimer’s Disease and related disorders annual 2004. London,

UK: Martin Dunitz Ltd, 2004:47-59.

18. Pantoni L, Inzitari D. Leukoaraiosis and cognitive impairment. In: Burns A, O’Brien J,

Ames D (Eds). Dementia, Third edition. London: Edward Arnold Publishers, 2005:546-

564.

19. Ogata J, Yamanishi H, Pantoni L. Neuropathology of ischemic brain injury. In: Fisher M

(editor). Handbook of Clinical Neurology, volume 92 (3rd

series) Stroke, Part I.

Edinburgh, Elsevier, 2009;92:93-116.

20. Pantoni L, Pescini F, Poggesi A. Physiopathology of large-vessel vascular dementia. In:

Wahlund L-O, Erkinjuntti T, Gauthier S (Eds). Vascular cognitive impairment in clinical

practice. Cambridge, Cambridge University Press, 2009:95-117.

21. Poggesi A, Pantoni L. Investigations in Primary Care. Frontiers in Neurology and

Neuroscience 2009;24:66-78.



68

Capitoli di libri (segue):

22. Pasi M, Poggesi A, Salvadori E, Pantoni L. Post-stroke dementia and cognitive

impairment. Frontiers in Neurology and Neuroscience 2012;30:65-69.

23. Poggesi A, Pantoni L. Neuropsychiatric aspects of vascular cognitive impairment. In:

Ferro JM (Ed). Neuropsychiatric Symptoms of Cerebrovascular Diseases. Springer

Science & Business Media, 2013.xxx.

24. Valenti R, Pantoni L. Secondary prevention after ischemic lacunar stroke. In:

Obviagele B, Turan TN (Eds). Ischemic Stroke Therapeutics. Springer International

Publishing Switzerland, 2016:137-146.




69

Capitoli di libri in italiano:

1. Inzitari D, Pantoni L. Demenze vascolari: risonanza magnetica morfologica. In: Tedeschi

G, Cirillo S, Caltagirone C. Le neuroimmagini delle demenze. Roma, Critical Medicine

Publishing Editore, 2005:129-148.

2. Pantoni L, Inzitari D. Demenza vascolare. In: Gambina G, Pasetti C. Introduzione alla

malattia di Alzheimer e alle altre demenze. Dalla clinica alla bioetica. Verona, Edizioni

Libreria Cortina 2008: 203-210.


70

Lavori in extenso pubblicati su atti di congressi nazionali ed internazionali:

1. Inzitari D, Pantoni L, Ginanneschi A, Marinoni M. Fisiopatologia dell'infarto lacunare e

della leucoaraiosi: ruolo dell'ipertensione arteriosa. In: Atti del convegno:

"L'ipertensione arteriosa. Recenti acquisizioni in tema di fisiopatologia e danno d'organo",

Firenze, 23 Maggio 1992, pp.49-54.

2. Amaducci L, Pantoni L, Inzitari D. Epidemiologia delle demenze non-Alzheimer: tante

idee, pochi fatti. In: Carreras M, Defanti CA, Cornelio F, Federico A (Eds). Atti del XI

Corso di Aggiornamento della Società Italiana di Neurologia. Bergamo, 1992. Monduzzi

Editore, pp.415-421.

3. Inzitari D, Pantoni L. Leucoencefalopatie di origine ischemica. In: Atti del 96(

Congresso della Società Italiana di Medicina Interna (Volume II). Roma: Edizioni Luigi

Pozzi, 1995, pp.24-34.

4. Inzitari D, Pantoni L. Le demenze vascolari sottocorticali. In: Atti del XXXVII

Congresso Nazionale della Società dei Neurologi Neurochirurghi e Neuroradiologi

Ospedalieri S.N.O., a cura di Bassi P, Marforio S, Gomitoni A. Como, 29-31 Maggio

1997, pp.188-191.

5. Inzitari D, Pantoni L. Trends in the therapy of vascular dementia. In: Proceedings of the

First International Congress on Vascular Dementia, Geneva (Switzerland), October 3-6,

1999 (Korczyn AD, editor). Monduzzi Editore, S.p.A., Bologna 1999: pp. 53-58.

6. Pantoni L. Should the term subcortical vascular dementia replace the eponym

"Binswanger's disease"? In: Proceedings of the First International Congress on Vascular

Dementia, Geneva (Switzerland), October 3-6, 1999 (Korczyn AD, editor). Monduzzi

Editore, S.p.A., Bologna 1999: pp. 5-9.

7. Erkinjuntti T, Inzitari D, Pantoni L, Wallin A, Scheltens P, Rockwood K, Roman GC,

Chui H, Desmond DW. Research criteria for subcortical vascular dementia in clinical

trials. In: Proceedings of the First International Congress on Vascular Dementia, Geneva

(Switzerland), October 3-6, 1999 (Korczyn AD, editor). Monduzzi Editore, S.p.A.,

Bologna 1999: pp. 37-42.


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Lettere pubblicate su riviste nazionali e internazionali:

1. Pantoni L, Inzitari D. Abnormal penetration of haptoglobin through the blood-brain-

barrier (BBB) into the cerebro-spinal fluid (CSF) in Alzheimer's disease patients [letter].

Acta Neurologica Scandinavica 1995;91:225.

2. Pantoni L, Inzitari D, for the European Task Force on Age-Related White Matter

Changes. New clinical relevance of leukoaraiosis [letter]. Stroke 1998;29:543.

3. Pantoni L, Bartolini L, Pracucci G, Inzitari D. Interrater agreement on a simple

neurological score in rats [letter]. Stroke 1998;29:871-872.

4. Pantoni L. Incomplete lacunar infarction: an alternative hypothesis [letter]. Acta

Neuropathologica (Berl) 1999;97:322.

5. Pantoni L, Inzitari D. Pathological examination in vascular dementia [letter]. American

Journal of Psychiatry 2002;159:1439-1440.

6. Pantoni L, Pescini F, Inzitari D, Dotti MT. Postpartum psychiatric disturbances as an

unrecognized onset of CADASIL [letter]. Acta Psychiatrica Scandinavica 2005;112:241.

7. Nannucci S, Pescini F, Valenti R, Ciolli L, Bianchi S, Dotti MT, Inzitari D, Pantoni L.

Stroke recurrence in an elderly cadasil patient on aspirin discontinuation due to severe

auto-immune thrombocytopenia [letter]. Aging Clinical and Experimental Research

2010;22:98-99.

8. Valenti R, Nannucci S, Pescini F, Bianchi S, Inzitari D, Pantoni L. High lipoprotein(a)

serum levels in three CADASIL families [letter]. Journal of Neurology 2012; 259:379-

380.

9. Pescini F, Nannucci S, Pantoni L. Response to letter regarding article “The Cerebral

Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephaòopathy

Scale. A screening tool to select patients for NOTCH3 analysis” [letter]. Stroke

2013;44.e19.

10. Pescini F, Poggesi A, Pantoni L. Letter by Pescini et al regarding article, "Peripheral

artery disease as a manifestation of cerebral autosomal dominant arteriopathy with

subcortical infarcts and leukoencephalopathy (CADASIL) and practical implications"

[letter]. Circulation 2013;128:e362. doi: 10.1161/CIRCULATIONAHA.113.003783.







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