PROTEINE DEL SISTEMA IMMUNITARIO Immunoglobuline …...(b) Protein Ill VI Vil Vill IX Vil Vill 10 20...

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PROTEINE DEL SISTEMA IMMUNITARIO Immunoglobuline MHCI MHC II RECETTORE T cellulare

Transcript of PROTEINE DEL SISTEMA IMMUNITARIO Immunoglobuline …...(b) Protein Ill VI Vil Vill IX Vil Vill 10 20...

Page 1: PROTEINE DEL SISTEMA IMMUNITARIO Immunoglobuline …...(b) Protein Ill VI Vil Vill IX Vil Vill 10 20 30 CDRI 40 WVRQAPGKGL EVQLVESGGGLVQPGGSLRLSCAASGFTFS D 50 E WV CDR2 60 sus CDR3

PROTEINE DEL SISTEMA IMMUNITARIO

Immunoglobuline

MHCI

MHC II

RECETTORE T cellulare

Page 2: PROTEINE DEL SISTEMA IMMUNITARIO Immunoglobuline …...(b) Protein Ill VI Vil Vill IX Vil Vill 10 20 30 CDRI 40 WVRQAPGKGL EVQLVESGGGLVQPGGSLRLSCAASGFTFS D 50 E WV CDR2 60 sus CDR3
Page 3: PROTEINE DEL SISTEMA IMMUNITARIO Immunoglobuline …...(b) Protein Ill VI Vil Vill IX Vil Vill 10 20 30 CDRI 40 WVRQAPGKGL EVQLVESGGGLVQPGGSLRLSCAASGFTFS D 50 E WV CDR2 60 sus CDR3
Page 4: PROTEINE DEL SISTEMA IMMUNITARIO Immunoglobuline …...(b) Protein Ill VI Vil Vill IX Vil Vill 10 20 30 CDRI 40 WVRQAPGKGL EVQLVESGGGLVQPGGSLRLSCAASGFTFS D 50 E WV CDR2 60 sus CDR3
Page 5: PROTEINE DEL SISTEMA IMMUNITARIO Immunoglobuline …...(b) Protein Ill VI Vil Vill IX Vil Vill 10 20 30 CDRI 40 WVRQAPGKGL EVQLVESGGGLVQPGGSLRLSCAASGFTFS D 50 E WV CDR2 60 sus CDR3
Page 6: PROTEINE DEL SISTEMA IMMUNITARIO Immunoglobuline …...(b) Protein Ill VI Vil Vill IX Vil Vill 10 20 30 CDRI 40 WVRQAPGKGL EVQLVESGGGLVQPGGSLRLSCAASGFTFS D 50 E WV CDR2 60 sus CDR3
Page 7: PROTEINE DEL SISTEMA IMMUNITARIO Immunoglobuline …...(b) Protein Ill VI Vil Vill IX Vil Vill 10 20 30 CDRI 40 WVRQAPGKGL EVQLVESGGGLVQPGGSLRLSCAASGFTFS D 50 E WV CDR2 60 sus CDR3
Page 8: PROTEINE DEL SISTEMA IMMUNITARIO Immunoglobuline …...(b) Protein Ill VI Vil Vill IX Vil Vill 10 20 30 CDRI 40 WVRQAPGKGL EVQLVESGGGLVQPGGSLRLSCAASGFTFS D 50 E WV CDR2 60 sus CDR3
Page 9: PROTEINE DEL SISTEMA IMMUNITARIO Immunoglobuline …...(b) Protein Ill VI Vil Vill IX Vil Vill 10 20 30 CDRI 40 WVRQAPGKGL EVQLVESGGGLVQPGGSLRLSCAASGFTFS D 50 E WV CDR2 60 sus CDR3
Page 10: PROTEINE DEL SISTEMA IMMUNITARIO Immunoglobuline …...(b) Protein Ill VI Vil Vill IX Vil Vill 10 20 30 CDRI 40 WVRQAPGKGL EVQLVESGGGLVQPGGSLRLSCAASGFTFS D 50 E WV CDR2 60 sus CDR3
Page 11: PROTEINE DEL SISTEMA IMMUNITARIO Immunoglobuline …...(b) Protein Ill VI Vil Vill IX Vil Vill 10 20 30 CDRI 40 WVRQAPGKGL EVQLVESGGGLVQPGGSLRLSCAASGFTFS D 50 E WV CDR2 60 sus CDR3
Page 12: PROTEINE DEL SISTEMA IMMUNITARIO Immunoglobuline …...(b) Protein Ill VI Vil Vill IX Vil Vill 10 20 30 CDRI 40 WVRQAPGKGL EVQLVESGGGLVQPGGSLRLSCAASGFTFS D 50 E WV CDR2 60 sus CDR3
Page 13: PROTEINE DEL SISTEMA IMMUNITARIO Immunoglobuline …...(b) Protein Ill VI Vil Vill IX Vil Vill 10 20 30 CDRI 40 WVRQAPGKGL EVQLVESGGGLVQPGGSLRLSCAASGFTFS D 50 E WV CDR2 60 sus CDR3
Page 14: PROTEINE DEL SISTEMA IMMUNITARIO Immunoglobuline …...(b) Protein Ill VI Vil Vill IX Vil Vill 10 20 30 CDRI 40 WVRQAPGKGL EVQLVESGGGLVQPGGSLRLSCAASGFTFS D 50 E WV CDR2 60 sus CDR3
Page 15: PROTEINE DEL SISTEMA IMMUNITARIO Immunoglobuline …...(b) Protein Ill VI Vil Vill IX Vil Vill 10 20 30 CDRI 40 WVRQAPGKGL EVQLVESGGGLVQPGGSLRLSCAASGFTFS D 50 E WV CDR2 60 sus CDR3
Page 16: PROTEINE DEL SISTEMA IMMUNITARIO Immunoglobuline …...(b) Protein Ill VI Vil Vill IX Vil Vill 10 20 30 CDRI 40 WVRQAPGKGL EVQLVESGGGLVQPGGSLRLSCAASGFTFS D 50 E WV CDR2 60 sus CDR3
Page 17: PROTEINE DEL SISTEMA IMMUNITARIO Immunoglobuline …...(b) Protein Ill VI Vil Vill IX Vil Vill 10 20 30 CDRI 40 WVRQAPGKGL EVQLVESGGGLVQPGGSLRLSCAASGFTFS D 50 E WV CDR2 60 sus CDR3
Page 18: PROTEINE DEL SISTEMA IMMUNITARIO Immunoglobuline …...(b) Protein Ill VI Vil Vill IX Vil Vill 10 20 30 CDRI 40 WVRQAPGKGL EVQLVESGGGLVQPGGSLRLSCAASGFTFS D 50 E WV CDR2 60 sus CDR3
Page 19: PROTEINE DEL SISTEMA IMMUNITARIO Immunoglobuline …...(b) Protein Ill VI Vil Vill IX Vil Vill 10 20 30 CDRI 40 WVRQAPGKGL EVQLVESGGGLVQPGGSLRLSCAASGFTFS D 50 E WV CDR2 60 sus CDR3
Page 20: PROTEINE DEL SISTEMA IMMUNITARIO Immunoglobuline …...(b) Protein Ill VI Vil Vill IX Vil Vill 10 20 30 CDRI 40 WVRQAPGKGL EVQLVESGGGLVQPGGSLRLSCAASGFTFS D 50 E WV CDR2 60 sus CDR3
Page 21: PROTEINE DEL SISTEMA IMMUNITARIO Immunoglobuline …...(b) Protein Ill VI Vil Vill IX Vil Vill 10 20 30 CDRI 40 WVRQAPGKGL EVQLVESGGGLVQPGGSLRLSCAASGFTFS D 50 E WV CDR2 60 sus CDR3
Page 22: PROTEINE DEL SISTEMA IMMUNITARIO Immunoglobuline …...(b) Protein Ill VI Vil Vill IX Vil Vill 10 20 30 CDRI 40 WVRQAPGKGL EVQLVESGGGLVQPGGSLRLSCAASGFTFS D 50 E WV CDR2 60 sus CDR3
Page 23: PROTEINE DEL SISTEMA IMMUNITARIO Immunoglobuline …...(b) Protein Ill VI Vil Vill IX Vil Vill 10 20 30 CDRI 40 WVRQAPGKGL EVQLVESGGGLVQPGGSLRLSCAASGFTFS D 50 E WV CDR2 60 sus CDR3
Page 24: PROTEINE DEL SISTEMA IMMUNITARIO Immunoglobuline …...(b) Protein Ill VI Vil Vill IX Vil Vill 10 20 30 CDRI 40 WVRQAPGKGL EVQLVESGGGLVQPGGSLRLSCAASGFTFS D 50 E WV CDR2 60 sus CDR3

SWITCH DELLE CATENE PESANTI

Page 25: PROTEINE DEL SISTEMA IMMUNITARIO Immunoglobuline …...(b) Protein Ill VI Vil Vill IX Vil Vill 10 20 30 CDRI 40 WVRQAPGKGL EVQLVESGGGLVQPGGSLRLSCAASGFTFS D 50 E WV CDR2 60 sus CDR3
Page 26: PROTEINE DEL SISTEMA IMMUNITARIO Immunoglobuline …...(b) Protein Ill VI Vil Vill IX Vil Vill 10 20 30 CDRI 40 WVRQAPGKGL EVQLVESGGGLVQPGGSLRLSCAASGFTFS D 50 E WV CDR2 60 sus CDR3

ANERGIA CLONALE Se in questa fase Ig viene in contatto con antigeni

Page 27: PROTEINE DEL SISTEMA IMMUNITARIO Immunoglobuline …...(b) Protein Ill VI Vil Vill IX Vil Vill 10 20 30 CDRI 40 WVRQAPGKGL EVQLVESGGGLVQPGGSLRLSCAASGFTFS D 50 E WV CDR2 60 sus CDR3
Page 28: PROTEINE DEL SISTEMA IMMUNITARIO Immunoglobuline …...(b) Protein Ill VI Vil Vill IX Vil Vill 10 20 30 CDRI 40 WVRQAPGKGL EVQLVESGGGLVQPGGSLRLSCAASGFTFS D 50 E WV CDR2 60 sus CDR3
Page 29: PROTEINE DEL SISTEMA IMMUNITARIO Immunoglobuline …...(b) Protein Ill VI Vil Vill IX Vil Vill 10 20 30 CDRI 40 WVRQAPGKGL EVQLVESGGGLVQPGGSLRLSCAASGFTFS D 50 E WV CDR2 60 sus CDR3
Page 30: PROTEINE DEL SISTEMA IMMUNITARIO Immunoglobuline …...(b) Protein Ill VI Vil Vill IX Vil Vill 10 20 30 CDRI 40 WVRQAPGKGL EVQLVESGGGLVQPGGSLRLSCAASGFTFS D 50 E WV CDR2 60 sus CDR3
Page 31: PROTEINE DEL SISTEMA IMMUNITARIO Immunoglobuline …...(b) Protein Ill VI Vil Vill IX Vil Vill 10 20 30 CDRI 40 WVRQAPGKGL EVQLVESGGGLVQPGGSLRLSCAASGFTFS D 50 E WV CDR2 60 sus CDR3
Page 32: PROTEINE DEL SISTEMA IMMUNITARIO Immunoglobuline …...(b) Protein Ill VI Vil Vill IX Vil Vill 10 20 30 CDRI 40 WVRQAPGKGL EVQLVESGGGLVQPGGSLRLSCAASGFTFS D 50 E WV CDR2 60 sus CDR3
Page 33: PROTEINE DEL SISTEMA IMMUNITARIO Immunoglobuline …...(b) Protein Ill VI Vil Vill IX Vil Vill 10 20 30 CDRI 40 WVRQAPGKGL EVQLVESGGGLVQPGGSLRLSCAASGFTFS D 50 E WV CDR2 60 sus CDR3

chain chromosome 14

chain chromosome 7

Page 34: PROTEINE DEL SISTEMA IMMUNITARIO Immunoglobuline …...(b) Protein Ill VI Vil Vill IX Vil Vill 10 20 30 CDRI 40 WVRQAPGKGL EVQLVESGGGLVQPGGSLRLSCAASGFTFS D 50 E WV CDR2 60 sus CDR3
Page 35: PROTEINE DEL SISTEMA IMMUNITARIO Immunoglobuline …...(b) Protein Ill VI Vil Vill IX Vil Vill 10 20 30 CDRI 40 WVRQAPGKGL EVQLVESGGGLVQPGGSLRLSCAASGFTFS D 50 E WV CDR2 60 sus CDR3
Page 36: PROTEINE DEL SISTEMA IMMUNITARIO Immunoglobuline …...(b) Protein Ill VI Vil Vill IX Vil Vill 10 20 30 CDRI 40 WVRQAPGKGL EVQLVESGGGLVQPGGSLRLSCAASGFTFS D 50 E WV CDR2 60 sus CDR3