Darunavir/ritonavir

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Reactions 1482, p18 - 14 Dec 2013 Darunavir/ritonavir Depressive syndrome: case report In an observational study of 65 HIV-infected patients, aged 40–49 years, 35 patients were switched from double ritonavir- boosted protease inhibitor therapy to darunavir/ritonavir either once or twice daily [dose and route not stated]. One of these patients [exact age and sex not stated] stopped darunavir/ ritonavir due to the onset of depressive syndrome [duration of treatment to reaction onset and outcome not stated]. Author comment: "[O]ne patient in the [darunavir/ ritonavir] arm stopped treatment due to side effects (depressive syndrome)". Curran A, et al. Efficacy and safety of switching double-boosted protease inhibitors to boosted darunavir in HIV-infected patients with virologic suppression. Journal of the International AIDS Society 15 (Suppl. 4): 162-163 abstr. P297, 11 Nov 2012. Available from: URL: http://dx.doi.org/10.7448/IAS.15.6.18350 - Spain 803096952 1 Reactions 14 Dec 2013 No. 1482 0114-9954/13/1482-0001/$14.95 Adis © 2013 Springer International Publishing AG. All rights reserved

Transcript of Darunavir/ritonavir

Page 1: Darunavir/ritonavir

Reactions 1482, p18 - 14 Dec 2013

Darunavir/ritonavir

Depressive syndrome: case reportIn an observational study of 65 HIV-infected patients, aged

40–49 years, 35 patients were switched from double ritonavir-boosted protease inhibitor therapy to darunavir/ritonavireither once or twice daily [dose and route not stated]. One ofthese patients [exact age and sex not stated] stopped darunavir/ritonavir due to the onset of depressive syndrome [duration oftreatment to reaction onset and outcome not stated].

Author comment: "[O]ne patient in the [darunavir/ritonavir] arm stopped treatment due to side effects(depressive syndrome)".Curran A, et al. Efficacy and safety of switching double-boosted proteaseinhibitors to boosted darunavir in HIV-infected patients with virologic suppression.Journal of the International AIDS Society 15 (Suppl. 4): 162-163 abstr. P297, 11Nov 2012. Available from: URL: http://dx.doi.org/10.7448/IAS.15.6.18350 -Spain 803096952

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Reactions 14 Dec 2013 No. 14820114-9954/13/1482-0001/$14.95 Adis © 2013 Springer International Publishing AG. All rights reserved