5to Informe de Farmaco

8/18/2019 5to Informe de Farmaco

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UNIVERSIDAD PRIVADA ANTENOR ORREGO

FACULTAD DE MEDICINA HUMANA

ESCUELA PROFESIONAL DE MEDICINA HUMANA

FARMACOLOGÍA BÁSICA

PRACTICA V

“ANALGESICOS, ANTIPIRETICOS Y ANTIINFLAMATORIOS E HIPNOANTALGICOS”

INTEGRANTES:

HORARIO PRÁCITCO: MIERCOLES 10:40am – 2:20 pm

MESA NÚMERO: 5

ASESORES: Dr. GALO G. ARÉVALO BENITEZ

Dra. ROSA ABANTO

TRUJILLO – PERÚ

!!" – #

AINES

Los A!""#$ama!or"os o %s!%ro"&%os &% pr"m%ra '%%ra(") "*"+% $as

a(!","&a&%s &% $a ("($oo-"'%asa 1 (o-/1 ("($oo-"'%asa 2 (o-/2 arras!ra

%$ "(o,%"%!% 3% $a (o-/1 !"%% #("o%s pro!%(!oras &% $a m(osa

http://es.wikipedia.org/wiki/Ciclooxigenasahttp://es.wikipedia.org/wiki/Ciclooxigenasahttp://es.wikipedia.org/w/index.php?title=Mucosa_g%C3%A1strica&action=edithttp://es.wikipedia.org/wiki/Ciclooxigenasahttp://es.wikipedia.org/wiki/Ciclooxigenasahttp://es.wikipedia.org/w/index.php?title=Mucosa_g%C3%A1strica&action=edit


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'5s!r"(a r"6) %&o!%$"o p$a3%!as a$ s%r spr"m"&a s pro&((") p%&%

'%%rar %#%(!os a&,%rsos so+r% %s!os or'a"smos.

La s%'&a '%%ra(") &% A!""#$ama!or"os o %s!%ro"&%os "*"+%

s%$%(!",am%!% $a (o-/2 (o(%!ra&o s a(!","&a& % %$ pro(%so "#$ama!or"o.

MECANISMO DE ACCI$N

La a((") +5s"(a %s $a "*"+"(") &% $a ("($oo-"'%asa %7"ma 3% (o,"%r!% %$

5("&o ara3"&)"(o % %&op%r)-"&os (8($"(os $os (a$%s s% !ras#orma % 9G

% !rom+o-aos $a "*"+"(") &% s s8!%s"s por $os AINEs s%r8a r%sposa+$%

&% s a(!","&a& !%rap!"(a &% ,ar"os %#%(!os !)-"(os &% %s!% 'rpo &%

#5rma(os.

Los AINEs a(!a$%s o p%&% "*"+"r $a ,8a &% $a $"poo-"'%asa por $o 3%

(o!";a #orm5&os% $%(o!r"%os o!ros %$%m%!os a(!",os por %s!o s%

(ompr%&% $a $"m"!a(") &% s!os #5rma(os para (o!ro$ar $os pro(%sos % $os

3% "!%r,%'a m%rosos m%&"a&or%s. La "*"+"(") &% $a a((") &% $a

("($oo-"'%asa %s &% #orma (omp%!"!",a r%,%rs"+$% r%&("%&o &% %s!a #orma$a s8!%s"s &% 9G %-(%p!o $a asp"r"a 3% "*"+% "rr%,%rs"+$%m%!% a(%!"$a&o

&% ma%ra (o,a$%!% %$ s"!"o a(!",o &% $a %7"ma por $o 3% $a "*"+"(") &% $a

("($oo-"'%asa &ra !o&a $a ,"&a &% $a p$a3%!a.

S% *a "&%!"#"(a&o &os !"pos &% ("($oo-"'%asa CO


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EFECTOS

1 A((") aa$'s"(a:

E $a a((") aa$'s"(a %s!a r%$a("oa&a (o $a "*"+"(") &% $a s8!%s"s &% 9Gpros!a'$a&"as a ",%$ (%!ra$ p%r"#r"(o. A ",%$ p%r"#r"(o pr%,"%% $a

s%s"+"$"7a(") &% $os o("(%p!or%s ma!"%% %$ m+ra$ #"s"o$)'"(o &%

r%sp%s!a &% %s!8m$os o("(%p!",os a ",%$ (%!ra$ po&r8a (os"&%rars%

"&(!or%s &% $a $"+%ra(") &% %ro!rasm"sor%s "*"+"&or%s &% $a r%sp%s!a

&o$orosa. So %#"(a(%s % (a&ros &o&% $a *"p%ra$'%s"a %s!a m%&"a&as por

pros!a'$a&"as por $o 3% s%r5 ;!"$%s % &o$or%s (o (ompo%!%

"#$ama!or"o (r)"(o o a'&o. So m5s a!"5$'"(os 3% aa$'s"(os % ra7)3% o +$o3%a $as 9G a $"+%ra&as. T"%% &os"s !%(*o por %("ma &% $a (a$

o am%!a %$ %#%(!o aa$'s"(o p%ro s" $os %#%(!os s%(&ar"os. No !"%%

%#%(!o a&"!",os %!r% $os AINES por $o 3% o s% &%+% aso("ar a 3% o

am%!a %$ %#%(!o aa$'s"(o s" $os s%(&ar"os. =a a 'ra ,ar"a+"$"&a&

% $a r%sp%s!a "&","&a$. S %#"(a("a $a ,a$orar%mos por EVA Es(a$a ,"sa$

a5$o'a &%$ 1 a$ 10. E$ pa("%!% r%spo&%: 1 o *a &o$or 10 %$ &o$or %s $o m5s

"!%so !o$%ra+$%. E$ o+>%!",o !%rap!"(o %s %$ EVA 1.

2 A((") a!"!rm"(a:

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",%$ (%!ra$. R%&(% $a $"+%ra(") $o(a$ &% 9GE2 % $a r%'") pr%)p!"(a

*"po!5$am"(a 3% r%'$a %$ !%rmos!a!o &% $a !%mp%ra!ra (orpora$. La 9GE2

(a $"+%ra(") %s %s!"m$a&a por $a a((") &% &"#%r%!%s p"r)'%os a(!;a

(omo m%&"a&or &% $a r%sp%s!a #%+r"$ a$ a$!%rar %$ p!o #">o &% $a !%mp%ra!ra.Los AINES r%&(% $a !%mp%ra!ra (orpora$ s" %s!a s% *aa pr%,"am%!%

am%!a&a por %$ p"r)'%o.

? A((") a!""#$ama!or"a:

IN@LAMACIN AGDA: S% &a o so$am%!% por $a "*"+"(") &% $a s8!%s"s &%

9G s"o por 3% so (apa(%s &% &%s%s!r(!rar $a s%(%("a &% *%(*os a


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E $as so$("o%s (o(%!ra&as &% *"&r)-"&os &% (ar+oa!os a$(a$"os

%s so$+$% (o &%s(ompos"(").

A112*%(+ -'3-1*)6721-+

Acciones analgésica, antitérmica y antiinflamatoria

E$ AAS a(%!"$a % "*"+% &% #orma "rr%,%rs"+$% $as ("($oo-"'%asas

m"%!ras 3% $a a((") "*"+"&ora &% s!as por $os sa$"("$a!os o

a(%!"$a&os %s r%,%rs"+$%. A&%m5s %$ AAS s% m%!a+o$"7a r5p"&am%!% a

5("&o sa$"(8$"(o %$ (a$ "*"+% in vitro s)$o &+"$m%!% $a pro&((") &%

pros!a'$a&"as. In vivo %$ %#%(!o aa$'s"(o &%$ AAS %s sp%r"or a$ &%$

sa$"("$a!o s)&"(o p%ro $a a(!","&a& a!""#$ama!or"a &% am+os %s s"m"$ar.

La (ompro+a(") &% 3% %$ sa$"("$a!o in vivo a &os"s a!""#$ama!or"as

"*"+% $a pro&((") &% pros!a'$a&"as s'"%r% 3% %s!a a((") %s

m%&"a&a por m%!a+o$"!o a(!",o. 9%s!o 3% $a po!%("a aa$'s"(a

a!"!rm"(a &%$ AAS 'ar&a r%$a(") (o s a(!","&a&

a!"("($oo-"'%5s"(a p%ro $a a(!","&a& a!""#$ama!or"a r%3"%r% &os"s

m5s %$%,a&as s% &%&(% 3% % %s!a ;$!"ma a((") "!%r,"%% !am+"

!a$ (omo a s% *a %-p%s!o o!ros m%(a"smos "&%p%&"%!%s &% $a

s8!%s"s &% pros!a'$a&"as.

Acciones metabólicas

A $as &os"s !"$"7a&as % $a maor8a &% ss "&"(a("o%s ($8"(as $os

sa$"("$a!os o "!%r#"%r% s"'"#"(a!",am%!% (o $os pro(%sos

m%!a+)$"(os %s%("a$%s. S" %m+ar'o a (o(%!ra("o%s %$%,a&as % %$

$8m"!% sp%r"or &% $as !"$"7a&as % %$ !ra!am"%!o &% $a ar!r"!"s

r%ma!o"&%a a#%(!a "!%sam%!% %$ m%!a+o$"smo "!%rm%&"ar"o

a3% o s% (oo(% % 3 'ra&o %s!o p%&% (o!r"+"r a$ %#%(!oa!"rr%m5!"(o ("%r!am%!% (o!r"+% a pro,o(ar %$ (a&ro !)-"(o por

so+r%&os"#"(a(").

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&"sm"% $a pro&((") &% AT9 "!%r#"%r% (o %$ m%!a+o$"smo a%ro+"o

&% $a '$(osa "*"+% $as &%s*"&ro'%asas $a /#os#o#r(!o("asa &% $a

'$()$"s"s $a ,8a &% $as p%!osas. La r%&((") &% $a pro&((") &% AT9

r%p%r(!% % $a pro&((") &% AM9( % &%!%rm"a&as r%a(("o%saa+)$"(as p. %>. $a s8!%s"s &% '$(osam"o'$(aos '$(opro!%8as


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(o$5'%o &%$ !%>"&o (o>!",o. As"m"smo p%&% or"'"ar &%p$%(") &%$

'$()'%o *%p5!"(o *"p%r'$(%m"a '$(osr"a.

Acciones sobre la respiración y el equilibrio ácido-base

A (o(%!ra("o%s %$%,a&as $os sa$"("$a!os %s!"m$a &"r%(!am%!% %$

(%!ro r%sp"ra!or"o: am%!a $a ,%!"$a(") &"sm"% $a 9CO2 por

(os"'"%!% #a,or%(% $a apar"(") &% alcalosis respiratoria 3% s%

o+s%r,a % a&$!os p%ro rara ,%7 % "6os. Como (omp%sa(")

am%!a $a %$"m"a(") r%a$ &% =CO?. Es!a a((") p%&% (o"("&"r (o

am%!o &%$ (osmo &% O2 &% $a pro&((") &% CO2 &%

m%!a+o$"!os 5("&os p"r;,"(o $5(!"(o (omo (os%(%("a "&"r%(!a &% $a

"!%r#%r%("a (o %$ m%!a+o$"smo &% (ar+o*"&ra!os $o (a$ !"%&% a

pro&("r acidosis metabólica. A$ pro'r%sar %$ (a&ro !)-"(o $a

%s!"m$a(") &%$ (%!ro r%sp"ra!or"o ,a s%'"&a &% &%pr%s") $o 3%

"mp"&% $a %$"m"a(") &%$ CO2 pro&("&o % $os !%>"&os. E (os%(%("a

apar%(% (a&ro &% acidosis metabólica respiratoria 3% (os!"!%

a r'%("a m&"(a.

Otras acciones

A &os"s +a>as p. %>. 1/2 'J&8a %$ sa$"("$a!o "*"+% $a s%(r%(") a(!",a &%

ácido úrico % %$ !;+$o r%a$ m"%!ras 3% a &os"s %$%,a&as p. %>. K F

'J&8a "*"+% $a r%a+sor(") a(!",a (ompor!5&os% (omo r"(os;r"(o. E$

&"#$"sa$ !"%% a(!","&a& r"(os;r"(a a &os"s +a>as. E$ AAS m%s!ra a

mar(a&a a(!","&a& antiagregante plaquetaria a &os"s "#%r"or%s a $as

aa$'s"(as. A (o(%!ra("o%s %$%,a&as "!%r#"%r% % $a s8!%s"s &%

pro!rom+"a.

OPIACEOS

PROPIEDADES GENERALES


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O'27(% 8 1-'-1&('4+&21-+ 94321-+

Los aa$'s"(os op"o"&%s (os!"!% 'rpo &% #5rma(os 3% s%

(ara(!%r"7a por pos%%r a#""&a& s%$%(!",a por $os r%(%p!or%s op"o"&%s.

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aa$'%s"a &% %$%,a&a "!%s"&a& pro&("&a pr"("pa$m%!% so+r% %$

SNC as8 (omo o!ros %#%(!os s+>%!",os 3% !"%&% a #a,or%(%r $a

"s!ara(") &% a (o&(!a &% a!oa&m""s!ra(") &%om"a&a

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p%!a(8($"(o %-"s!%!% % %$ op"o >'o %-!ra8&o &% $a a&orm"&%ra Papaver

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s%r (os"&%ra&a &%r",a&o &%$ #%a!r%o o &%r",a&o &% $a 4/

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#%a!r"(os: $a 1*.(4%- m%!"$mor#"a &% m%or a(!","&a& aa$'s"(a

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b! &%r",a&os +%("$"so3"o$8"(os %!r% $os 3% &%s!a(a $a /-/-;('2%-

$a %*+1-/2%-< E "!%!o &% r%&("r ss prop"%&a&%s m5s

p%r"("osas s% *a r%a$"7a&o mo&"#"(a("o%s &% $a %s!r(!ra mor#8"(a

3% *a or"'"a&o m%rosas #am"$"as &% op"o"&%s.

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a!a'o"s!as pros. M5s a&%$a!% s% %-p$"(ar5 $a +as% &% %s!a

om%($a!ra. S% s%$% !"$"7ar &% #orma "&"s!"!a $os !rm"os opiáceo

opioide S" %m+ar'o % s%!"&o %s!r "(!o opiáceo s% r%#"%r%%sp%(8#"(am%!% a $os pro&(!os o+!%"&os &%$ >'o &% $a a&orm"&%ra &%$

op"o por %-!%s") a $os pro&(!os 38m"(am%!% &%r",a&os &% $a

mor#"a m"%!ras 3% opioide a+ar(a a$ (o>!o &% (a$3"%r ss!a("a

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#5rma(o a!a'o"s!a a$o-oa.

a! "structura pentac#clica Compr%&% ,ar"os 'rpos:a 9ro&(!os a!ra$%s &%$ op"o: mor#"a (o&%8a !%+a8a.


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+ D%r",a&os s%m"s"!!"(os: $os a'o"s!as %!"$mor#"a *%ro8a

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%$ a'o"s!aJa!a'o"s!a m"-!o a$+#"a $os a!a'o"s!as pros

a$o-oa N/a$"$oro-"mor#oa a$!r%-oa.

b! "structura $e%ac#clica& oripavinas Compr%&% %$ a'o"s!a pro

%!or#"a &% 'ra po!%("a op"5(%a $a ("pr%or#"a %$ a!a'o"s!a

&"pr%or#"a %$ a'o"s!a par("a$ +pr%or#"a.

c! "structura tetrac#clica& morfinanos Compr%&% %$ a'o"s!a $%,or#5 %$

a!a'o"s!a $%,a$or#5 N/a$"$/$%,or#5 %$ a'o"s!aJa!a'o"s!a m"-!o

+!or#ao$. E$ &%-!ror#5 %s %s!%r%o"s)m%ro &%$ $%,or#5 3% (ar%(%

&% a(!","&a& op"o"&%.

d! "structura tric#clica& ben'omorfanos Compr%&% $os

a'o"s!asJa!a'o"s!as m"-!os p%!a7o("a %!o("($a7o("a

("($a7o("a.

e! "structura bic#clica Co!"%% a %s!r(!ra m s"mp$"#"(a&a 3%

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%s!%r%os%$%(!",a sa!ra+$% (omp%!"+$% &%mos!raro $a %-"s!%("a &%

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%sp%(8#"(as por o o!ro !"po &% r%(%p!or s% r%a$"7aro m%rosas

mo&"#"(a("o%s % $as %s!r(!ras p%p!8&"(as 3% *a or"'"a&o

;m%ro "'%!% &% $"'a&os p%p!8&"(os op"o"&%s (o a#""&a&%s

po!%("as m &",%rsas por $os !r%s !"pos &% r%(%p!or%s. Los ;$!"mos

pp!"&os a!ra$%s &%s(+"%r!os *a s"&o $os !%!rapp!"&os(%.*3*'2%-+ 1 2 (a s%$%(!","&a& por %$ r%(%p!or m %s &% 4.000 a


10/24

1F.000 ,%(%s maor 3% por %$ & %$ . Los pp!"&os s"!!"(os s%$%

s%r pro&("&os para "(r%m%!ar s a#""&a& s s%$%(!","&a& por

&%!%rm"a&o !"po &% r%(%p!or para a$ar'ar $a &ra(") &% s a((") a$

s%r m%os s%s"+$%s a $as p%p!"&asas.

Las !("(as &% +"o$o'8a mo$%($ar (os"'"%ro ($oar $os !r%s !"pos

pr"("pa$%s por %s!% or&% %$ &, %$ %$ m pr"m%ro % ra!) ra!a

&%sps % $a %sp%("% *maa.

A1&2;-126% .( '(1(/&*'(+ 8 1*%+(1(%12-+

3*)(1)-'(+

Co %-!raor&"ar"a #r%(%("a $a r%sp%s!a &% a %roa a $a a((")

&% op"o"&% s% (ara(!%r"7a por:

a! I*"+"(") &% $a a(!","&a& +"o%$(!r"(a

b! "*"+"(") &% $a $"+%ra(") &%$ %ro!rasm"sor % 3% %sa %roa s%

*a %sp%("a$"7a&o s%a (a$ #%r% s a!ra$%7a a(!",a&ora o "*"+"&ora.

Los r%(%p!or%s op"o"&%s s% %(%!ra a(op$a&os a &",%rsas #ormas &%

pro!%8as G"JGo s%'; $a $o(a$"7a(") %roa$ &%$ r%(%p!or s%s"+$%s

!o&as %$$as a $a !o-"a pertussis La a(!",a(") &% $as pro!%8as Ga"JGao

pro,o(a "*"+"(") &% $a a&%"$"$("($asa (o r%&((") &%$ AM9( ap%r!ra

&% (aa$%s &% ("%rr% &% (aa$%s &% Ca2. E$ am%!o &% $a

(o&(!a("a &%$ pro&(% *"p%rpo$ar"7a(") &% m%m+raa r%&((")

&% $a &ra(") &%$ po!%("a$ &% a((") % "*"+"(") &% $a a(!","&a& &%

&%s(ar'a &% po!%("a$%s &% a((") por par!% &% $a %roa. La

(os%(%("a %s a ($ara "*"+"(") &% $a a(!","&a& +"o%$(!r"(a &% $a

%roa % $a !%rm"a(") %r,"osa a r%&((") &% $a (apa("&a& &%

$"+%rar %$ %ro!rasm"sor. S% *a (ompro+a&o %s!% !"po &% r%sp%s!a %m;$!"p$%s s"!"os &%$ SNC %$ SN9: locus coeruleus, *"po!5$amo m&$a

%sp"a$ ;($%o para+ra3"a$ 'a'$"os ra38&%os p$%-o s+m(oso &%

$a par%& "!%s!"a$. Es "mpor!a!% s%6a$ar 3% %$ m"smo !"po &% (aa$%s

&% a#%(!a&os por $os op"o"&%s %s !am+" "*"+"&o por $os #5rma(os

3% a(!",a $os a2/a&r%o(%p!or%s. La "*"+"(") &% $os (aa$%s &% Ca2

a$'os &% $os (a$%s so &% !"po N (o r%&((") &% $a %!ra&a &%

%s!% "o pro,o(a apar!% (am+"os &% po!%("a$ &% m%m+raa a"*"+"(") &% $a $"+%ra(") &% %ro!rasm"sor%s. La r%&((") &% $os


11/24

",%$%s &% AM9( r%p%r(!% % %$ %s!a&o &% #os#or"$a(") &% m;$!"p$%s

pro!%8as"!ra%roa$%s "($"&as $as 3% s% %(%!ra % %$ ;($%o

para r%'$ar pro(%sos &% !ras(r"p(") a par!"r &% '%%s &% a((")

"m%&"a!a &% a((") !ar&8a.

FARMACOS UTILI>ADOS:

MORFINA

La mor#"a %s a$(a$o"&% #%a!r%o &%$ op"o

s"%&o pr%para&o %$ s$#a!o por %!ra$"7a(") (o

5("&o s$#;r"(o. La mor#"a %s a ss!a("a

(o!ro$a&a op"o"&% a'o"s!a !"$"7a&a %

pr%m%&"(a(") a%s!%s"a aa$'%s"a !ra!am"%!o

&%$ &o$or aso("a&o a $a "s3%m"a m"o(5r&"(a para

$a &"s%a aso("a&a a$ #ra(aso ,%!r"($ar "73"%r&o a'&o %&%ma p$moar. La

mor#"a %s po$,o +$a(o (r"s!a$"o "o&oro so$+$% % a'a. La %s!r(!ra

mo$%($ar %s C1=1NO?2 =2SO4 F=20 (o p%so mo$%($ar F.?. E$

s$#a!o &% mor#"a %s 38m"(am%!% &%s"'a&o (omo s$#a!o //D"&%*"&ro/4

F/%po-"/1/m%!"$$/Faamor#"a/?/&"o$ s$#a!o 2:1sa$ p%!a*"&ra!o.

E$ pr%("so m%(a"smo &% a((") &% $a mor#"a o!ros op"o"&%s o %s (oo("&o

a3% s% (r%% 3% %s!a r%$a("oa&o (o $a %-"s!%("a &% r%(%p!or%s %s!r%o

%sp%(8#"(os op"o"&%s pr%s"5p!"(os pos!s"5p!"(os % %$ s"s!%ma %r,"oso

(%!ra$ SNC o!ros !%>"&os. Los op"o"&%s "m"!a $a a((") &% $as %&or#"as

pro&("%&o a "*"+"(") &% $a a(!","&a& &% $a a&%"$("($asa. Es!o s%

ma"#"%s!a por a *"p%rpo$ar"7a(") %roa$ (o spr%s") &% $a &%s(ar'a%spo!5%a r%sp%s!as %,o(a&as. Los op"o"&%s !am+" "!%r#"%r% % %$

!raspor!% !rasm%m+raa &% "o%s (a$("o a(!;a % $a m%m+raa pr%s"5p!"(a

"!%r#"r"%&o (o $a $"+%ra(") &%$ %ro!rasm"sor.

TRAMADOL

E$ !rama&o$ %s aa$'s"(o &% a((") (%!ra$ (a %#"(a("a %s &%+"&a a $as"%r'"a a &os"s !%rap!"(as &%: %#%(!o op"o"&% &%+"&o a $a #">a(") so+r% $os


12/24

r%(%p!or%s op"5(%os &% !"po . %#%(!o moo/

am"r'"(o (%!ra$ &%+"&o a a "*"+"(") &% $a

r%(ap!a(") &% $a ora&r%a$"a &% $a

s%ro!o"a m%(a"smo "mp$"(a&o % %$ (o!ro$ &%

$a !rasm"s") o("(%p!",a.

@arma(o&"5m"(a: % $os s%r%s *maos

a"ma$%s %$ !rama&o$ %s m%!a+o$"7a&o pr"("pa$m%!% por &%sm%!"$a(") O/ N/

(o>'a(") s+s"'"%!%. D% ma%ra (o!ras!a!% (o %$ (aso &% $os a"ma$%s

% $os s%r%s *maos s% %$"m"a m(*o m5s &ro'a "!a(!a % $a or"a. Apar!%

&%$ m%!a+o$"!o O/&%sm%!"$!rama&o$ M1 !o&os $os &%m5s m%!a+o$"!os so

#arma(o$)'"(am%!% "a(!",os. V"&as m%&"as +"o$)'"(as &% !rama&o$ s

m%!a+o$"!o M1 &%sps &% a&m""s!ra(") ora$ % *maos: % s%ro . .4

*oras r%sp%(!",am%!% % or"a .2 .2 *oras r%sp%(!",am%!%. D%sps &%

$a a&m""s!ra(") ora$ %$ !rama&o$ %s a+sor+"&o r5p"&o (as" por (omp$%!o por

$o m%os 0. Las (o(%!ra("o%s sr"(as m5-"mas s% a$(a7a as 2

*oras &%sps &% $a a&m""s!ra(") &% !rama&o$. La +"o&"spo"+"$"&a& a+so$!a

&% !rama&o$ ora$ %s &% (%r(a &% F.

?ETOROLAC @?ETOROLACO ACIDO HETERO ARIL ACTICO:

Es po!%!% aa$'s"(o p%ro pos%%

s)$o mo&%ra&a %#"(a("a a!""#$ama!or"a.

Es o &% $os po(os a!""#$ama!or"os o

%s!%ro"&%s apro+a&os para a&m""s!ra(")

par%!%ra$.

E$ %!oro$a(o %s a!""#$ama!or"o o%s!%ro"&% (o a(("o%s aa$'s"(as

a!""#$ama!or"as a!"p"r!"(as (o m%(a"smo &% a((") %s!5

r%$a("oa&o (o s (apa("&a& "*"+"!or"a &% $a s8!%s"s &% pros!a'$a&"as

%#%(!o aa$'s"(o p%r"#r"(o.

9rop"%&a&%s #arma(o$)'"(as:

• E$ %!oro$a(o "*"+% $a +"os8!%s"s &% pros!a'$a&"asH pos%%a(!","&a& a!"p"r!"(a a!""#$ama!or"a aa$'s"(a p%ro %


13/24

(a!"#"(a("o%s &% "#$ama(") s a(!","&a& aa$'s"(a s"s!m"(a

%s m(*o maor 3% $a a!""#$ama!or"a.

• A &"#%r%("a &% $os a'o"s!as op"o&%s $% %!oro$a(o o '%%ra

!o$%ra("a %#%(!os &% a+s!"%("a " &%pr%s") r%sp"ra!or"a.

• 9os%% !am+" a(!","&a& a!""#$ama!or"a s" s% ap$"(a &"r%(!am%!%

% %$ o>o.

• I*"+% $a a'r%'a(") p$a3%!ar"a p%&% "("!ar $a #orma(") &%

;$(%ras '5s!r"(as.

@arma(o("!"(a m%!a+o$"smo:

•

D%sps &% "'%s!") o ap$"(a(") "!rams($ar %$ %!oro$a(o s%a+sor+% (o rap"&%7 a$(a7a (o(%!ra("o%s p$asm5!"(as

m5-"mas % ?0 a F0 m".

• La +"o&"spo"+"$"&a& &%sps &% "'%r"&o %s &% 0 % prom%&"o.

• S% %-(r%!a (o a ,"&a m%&"a &% %$"m"a(") &% 4 a *oras.

• La %-(r%(") por or"a (ompr%&% 0 apro-"ma&am%!% &%

#5rma(o %$"m"a&o. 0 s% %-(r%!a s" mo&"#"(a("o%s %$ r%s!o

% $a #orma &% (o>'a&o '$(oro"&a&o.• La ,%$o("&a& &% %$"m"a(") %s m%or % s>%!os (o "s#"("%("a

r%a$.

Ap$"(a("o%s !%rap!"(as:

S% !"$"7a (o!ra %$ &o$or pos! op%ra!or"o % ,%7 &% $os op"o&%s s%

a&m""s!ra por $a ,8a "!rams($ar ora$.

E#%(!os !)-"(os:

I($% somo$%("a mar%os (%#a$%a &o$or 'as!ro"!%s!"a$ &"sp%ps"a

5s%a as8 (omo &o$or % %$ s"!"o &% $a "%((").

II< OBJETIVOS

#< O(&2;*+ G(%('-)(+1. E(o!rar %$ p%r"o&o &% $a!%("a &% %$ ("&o a(%!"$sa$"(8$"(o


14/24

2. O+s%r,ar $a %#"(a("a &%$ ("&o a(%!"$sa$"(8$"(o

?. Comparar $a a((") &%$ ("&o a(%!"$sa$"(8$"(o (o $a a((") &%$

%!oro$a(o

4. O+s%r,ar $as r%a((") &%$ Ra!!s ra!!s ,ar a$+"a% $os &"#%r%!%s

,o$!a>%s ap$"(a&os.

III< HIP$TESIS

1. E$ %!%ro$a(o !"%% a a(("P aa$'s"(a mas %#"(a7 3% %$ A("&o A(%!"$

Sa$"(8$"(o

2. E$ Trama&o$ !"%% a a((") aa$'s"(a &% maor %#"(a7 3% $a Mor#"a.

?. E$A("&o A(%!"$ Sa$"(8$"(o !"%% a a(("o a!"#$ama!or"a &% maor

%#"(a("a 3% %$ %!%ro$a(o.

IV< PROBLEMA

• QEs %$ %!%ro$a(o aa$'s"(o &% maor %#"(a("a 3% %$ A("&o As(%!"$

Sa$"(8$"(o

• QEs %$ A("&o A(%!"$ Sa$"(8$"(o a!"#$ama!or"o m5s %#"(a7 3% %$

%!%ro$a(o

• QEs %$ Trama&o aa$'s"(o m5s %#"(a7 3% $a Mor#"a

V< MATERIALES Y MTODO:

#< MATERIALES:

A%23-)(+

• 4 ra!o%s Rattus ratus var albina

F0'3-1*+:

• A("&o a(%!"$sa$"(8$"(o so$. 2


15/24

• %!oro$a(o so$. ?

• Mor#"a C$or*"&ra!o so$. 1.

• Trama&o$ C$or*"&ra!o so$. F

D( )-*'-&*'2*:• A'a

• %r"'as.

• A'a &%s!"$a&a

• R%$o>.

• a$a (o%(!a&a a %$%(!r"("&a&.

• R%'$a&or &% ,o$!a>% 0 ,o$!"os a 100 ,o$!"os.

• G8a &% pr5(!"(a &% #arma(o$o'8a.

• L"+r%!a &% !oma &% ap!%s.

< MTODO:

I< ANALGESICOS, ANTIPIRETICOS Y ANTIINFLAMATORIOS

A< A%&-)721*+ O=H2.'*2(%*21*:

E/('2(%12- #: A12.* -1(&2)+-)214)21* (% R-&++ '-&&+ ;-' -)2%-

1. 9%sar a"ma$.


16/24

2. Co!ro$ +asa$: m+ra$ %$(!r"(o % ,o$!"os.

?. A("&o a(%!"$sa$"(8$"(o: So$. 2 % &os"s &% 10m'J100' p.(. ,8a SC.

4. Co!ro$ pos! #5rma(o: a $os 1020?0 m"!os ,%r m+ra$ %$(!r"(o %

,o$!"os.

B< A%&-)721*+ A12.* H(&('* A'2) A1&21*:

E/('2(%12- #: ?(&*'*)-1* (% R-&&+ '-&&+ ;-' -)2%-<

1. 9%sar a"ma$.

2. Co!ro$ Basa$: m+ra$ %$(!r"(o % ,o$!"os.

?. %!oro$a(o: so$(") ? &os"s &% 1Fm'J100' p.(. ,8a SC.

4. Co!ro$ pos! #5rma(o: a $os 1020?0 m"!os ,%r s m+ra$ %$(!r"(o

% ,o$!"os.

II<

HIPNOANTALGICOS

A< 2/%*-%&-)721*+ O/2-1(*+ F(%-%&'(%21*+:

E/('2(%12- #: M*'2%- C)*'2.'-&* (% R-&&+ '-&&+ ;-' -)2%-<

1. 9%sar a"ma$.2. Co!ro$ Basa$: m+ra$ %$(!r"(o % ,o$!"os.


17/24

?. Mor#"a C$or*"&ra!o: so$(") 1 &os"s &% 2Fm'J'. p.(. ,8a SC.

4. Co!ro$ pos! #5rma(o: a $os 1020?0 m"!os ,%r s m+ra$ %$(!r"(o

% ,o$!"os.

B< H2/%*=A%&-)721*+ O/2*.( B(%1(%21*+:

E/('2(%12- #: T'-3-.*) C)*'2.'-&* (% R-&&+ '-&&+ ;-' -)2%-<

F. 9%sar a"ma$.

. Co!ro$ Basa$: m+ra$ %$(!r"(o % ,o$!"os.

. Trama&o C$or*"&ra!o: So$. F &os"s &% 40m'J'. p.(. ,8a SC.

. Co!ro$ pos! #5rma(o: a $os 1020?0 m"!os ,%r s m+ra$ %$(!r"(o

% ,o$!"os.

VI< RESULTADOS

9%so a"ma$ Co!ro$ @5rma(os Dos"s Dos"s

Co!ro$

9os! #5rma(o


18/24

Basa$ Es!5&ar 10 20 ?0140' 1,o$ AAS 100m'J' 0m$ F, 1F, 20,

1?0' 1,o$ %!%ro$a(o 1Fm'J' 00m$ F, 1F, 40,

1F0' 1,o$ Mor#"a 2Fm'J' 014m$ K100, K100, K100,

10' 1,o$ Trama&o$ 40m'J' 01?m$ F0, 0, 0,

#< ANALGSICOS, ANTIPIRTICO Y ANTINFLAMATORIOS

A< A%&-)721*+ =H2.'*2(%*21*:

a. ("&o a(%!"$ sa$"(8$"(o % Ca,"a por(%$$s.: F % &os"s &%

10m'J100' p.( ,8a s+(!5%a.

Cálculo de dosis:

P(+*: 120 '.

D*+2+ ;*)3(%: 0.m$.

Basa$: 0.01 - 0 , U 0.,

1F : 20 ,

20 : 40 ,

4F : F0 ,

C*3(%&-'2*:

A("&o or'5"(o p%r!%%("%!% a $a #am"$"a &% $os AINES


19/24

La asp"r"a % #orma (o,a$%!% mo&"#"(a $as &os ,ar"%&a&%s &% ("($oo-"'%asas

1 2. A$ "*"+"r$as "*"+% $a pro&((") &% pros!a'$a&"as p%ro o

spr"m% $as ,8as &% $a $"poo-"'%asa " $a #orma(") &% $%(o!r"%os.

La asp"r"a por s%r 5("&o or'5"(o s% a(m$a % s"!"os &% "#$ama(") $o

(a$ (os!"!% a prop"%&a& #arma(o("!"(a a!ra(!",a &% %s!% pro&(!o 3%

s% pr%!%&% sar (omo a!""#$ama!or"o.

E %sp%("a$ $a asp"r"a pro&(% "*"+"(") s%$%(!",a por $a "so#orma (os!"!!",a

CO


20/24

a. %!oro$a(o % ra!!s ra!!s ,ar a$+"a.: ? % &os"s &% 1.Fm'J100'

p.( ,8a s+(!5%a.

Cálculo de dosis:

P(+*: 12F '.

D*+2+ ;*)3(%: 0.02 m$.

Basa$: 0.01 - 0 , U 0.,

1F : 40 ,

20 : F0 ,

4F : 0 ,

C*3(%&-'2*:

Es AINES 3% "mp"&% $a a(("o &% $a ("($oo-"'%asa "*"+"%&o as" $a

s"!%s"s &% pros!a'$a&"as pos%% a maor a(!","&a& aa$'%s"(a s"s!%m"(a.

No ppro&(% %#%(!os &% a+s!"%("a " &%pr%s"o r%sp"ra!or"a por $o 3%

pr%s%!a a ,%!a>a #r%!% a $os *"poa$!a'"(os op"o&%s.

E$ %!aro$a(o "*"+% $a a'r%'a("o p$a3%!ar"a p%ro pr%&"spo% a$ or'a"smo a

$a #orma("o &% $(%ras 'as!r"(as.

E$ %!aro$a(o %s %-(r%!a&o por or"a 0H s"%&o s ,%$o("&a& &%

%$"m"a("o m%or % a("aos % pa("%!%s (o "s#"("%("a r%a$.

D%+"&o a 3% %$ %!aro$a(o "*"+% $as ,8as CO


21/24

A< H2/%*=A%&0)721*+ O/2-1(*+ F(%-%&'(%21*+:

a. Mor#"a ($or*"&ra!o % ra!!s ra!!s ,ar a$+"a: F % &os"s &%

10m'J100' p.( ,8a s+(!5%a.

Cálculo de dosis:

P(+*: 120 '.

D*+2+ ;*)3(%: 0.?m$.

Basa$: 1,

1F : 0,

20 : F ,

4F : 100 ,

C*3(%&-'2*:

Es aa$'%s"(o (%!ra$ 3% a(!a so+r% $os r%(%p!or%s M" appa

&"sm%&o $a #orma("o &% AM9( a(!",a&o $os (aa$%s &% % "*"+"%&o

$os (a%$s &% (a$("o am%!a$ %$ m+ra$ &%$ &o$or (o (or!o p%r"o&o &%

$a!%("a !am+"% a(!a % %$ SNC (omo %ro&%pr%sor.

Es pr%#%r"+$% a&m""s!rar %s!% #arma(o por ,"a par%!ra$ s% %(%!ra %

sa'r% $"+r% "&o a pro!%"as p$asma!"(a ?F ss m%!a+o$"!os so mor#"a

moo'$(oro"&o mor#"a &"'$(oro"&o s% &"s!r"+% % !o&os $os !%>"&os

!%"%&o %#%(!os "mpor!a!%s % %$ (ora7o a 3% $o $$%,a a +ra&"(ar&"a

&"sm% $a pr%s"o ar!%r"a$ *as!a p&"%&o (asar S*o o!ro %#%(!o "mpor!a!%

%s 3% p%&% (asar a &%pr%s"o +$+ar o(as"oa&o paro r%sp"ra!or"o.Es!% #arma(oo s% %-(r%!a por $a or"a (omo mor#"a s m%!a+o$"!os !am+"%

s% p%&% %-(r%!ar % *%(%s s&or +"$"s.

A%-)2+2+: % $a pra(!"(a s% p&o (ompro+ar $a %#"(a("a &% $os aa$'%s"(os

(%!ra$%s a &"#%r%("a &% $os a%$'%s"(os $o(a$%s a 3% (o mor#"a am%!o

mas %$ m+ra$ &%$ &o$or o+s%r,a&o s %#%(!o aa$'%s"(o a $os 1F m"!os &%

*a+%r$% a&m""s!ra&o %$ #arma(o. 9%ro pos%% mas !o-"("&a& 3% $os aa$'%s"(os$o(a$%s por a(!ar a ",%$ (%!ra$.


22/24

B< H2/%*=-%&0)721*+ O/2*.(+ B(%1(%2*+:

a. Trama&o$ ($or*"&ra!o % ra!!s ra!!s ,ar a$+"a.: F % &os"s &%

40m'J100' p.( ,8a s+(!5%a.

Cálculo de dosis:

P(+*: 120 '.

D*+2+ ;*)3(%: 0.1m$.

Basa$: 1,

1F : 0 ,

20 : 0 ,

4F : 0 ,

C*3(%&-'2*:

E$ !rama&o$ %s *"poa!a$'"(o ar(o!"(o a'o"s!a &+"$ &% $os r%(%p!or%s

op"o&%s m".

S m%(a"smo &% a((") %s!a &a&o por $a "*"+"(") &% $a (ap!a(") &%

ora&r%a$"a s%ro!o"a.

Es m ;!"$ % %$ !ra!am"%!o &%$ &o$or $%,% a mo&%ra&o. S" %m+ar'o s

%#"(a("a % %$ !ra!am"%!o &%$ &o$or "!%so o (r)"(o %s %s(asa.

9or s%r #5rma(o op"o&% p%&% (asar &%pr%s") r%sp"ra!or"aH s 'ra&o &%

%s!r%6"m"%!o %s m%or.E$ #5rma(o !"%% m%!a+o$"smo *%p5!"(o %-(r%(") r%a$.

E!r% $os %#%(!os a&,%rsos o+s%r,a+$%s so $as as%as ,)m"!os mar%os

+o(a s%(a s%&"(") (%#a$'"aH %$ #5rma(o &%+% %,"!ars% % pa("%!%s (o

a!%(%&%!%s &% a&"(").

La aa$'%s"a &ra apro-"ma&am%!% *oras.

CONCLUSIONES


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E$ A("&o A(%!"$sa$"(8$"(o !"%% (omo m%(a"smo &% a((") $a "*"+"(") &% $a

("($oo-"'%asa CO%. La *"p%rpo$ar"7a("o &%

m%m+raa por a(!",a(") &% (orr"%!% &%$ po!as"o $a $"m"!a(") % $a %!ra&a

&% (a$("o por spr%s") &% $as (orr"%!%s so m%(a"smos m pro+a+$%s para

%-p$"(ar %$ +$o3%o &% op"o"&%s &% $a &%s(ar'a &% NT $a !rasm"s") &%$ &o$or

% &",%rsas ,8as %roa$%s.

E$ %!oro$a(o "*"+% $a +"os8!%s"s &% pros!a'$a&"asH pos%% a(!","&a&

a!"p"r!"(a a!""#$ama!or"a. A &"#%r%("a &% $os a'o"s!a op"o"&%s %s!% o

'%%ra !o$%ra("a. I*"+% $a a'r%'a(") p$a3%!ar"a p%&% "("!ar $a #orma(")

&% $(%ras '5s!r"(as.

E$ %!aro$a(o m%s!ra maor po!%("a 3% %$ a("&o a(%!"$sa$"(8$"(o.

La mor#"a m%s!ra maor po!%("a 3% %$ !rama&o$.

E$ !rama&o$ %s (os"&%ra&o op"5(%o s"!!"(o 3% %#%(!;a s a((") &%

aa$'s"(o so+r% $os r%(%p!or%s op"o"&%s (%!ra$%s &%$ !"po M.

a ,%7 3% s% % a %$$os "(r%m%!a $a p%rm%a+"$"&a& /a$ (omo

(os%(%("a a *"p%rpo$ar"7a(") p%rma%!% %!o(%s &"#"($!a $a

&%spo$ar"7a(") &% $a m%m+raa %roa$ pro&("%&o (omo %#%(!o #"a$ $a

"*"+"(") &% $os "mp$sos &o$orosos.E-"s!% !r%s r%(%p!or%s a ",%$ (%!ra$ ",o$(ra&os % %$ &o$or: .

La mor#"a %s a a$(a$o"&% #%a!r%"(o 3% !"%% a((") aa$'s"(a a&"(!",a

r%$a>a!% ms($ar.

La mor#"a a ",%$ &%$ SNC ,a %>%r(%r a a((") &%pr%sora '%%ra&o &% %s!a

#orma s%6o pro#&o r%sp"ra(") &%pr"m"&a m"os"s.

BIBLIOGRAFIA


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