Alberto Angeli, Ernesto Canalis, Andrea Giustina, Claudio Marcocci

J.D. Adachi (Canada)S. Adami (Italy)

M. Almeida (USA)A. Angeli (Italy)

R. Alten (Germany)J.P. Bilezikian (USA)

F. Bertoldo (Italy)G. Bianchi (Italy)

S. Bombardieri (Italy)O. Bruyere (Belgium)

E. Canalis (USA)F. Cetani (Italy)

I. Chiodini (Italy)M. Cutolo (Italy)

O. Di Munno (Italy)B. Frediani (Italy)S. Giannini (Italy)A. Giustina (Italy)

S.R. Goldring (USA)N.C. Harvey (UK)

L. Hofbauer (Germany)G.C. Isaia (Italy)

G. Lombardi (Italy)C. Marcocci (Italy)G. Mazziotti (Italy)S. Minisola (Italy)

L. Moro (Italy)A. Nilsson (Sweden)

R. Nuti (Italy)M. Rauner (Germany)R. Rizzoli (Switzerland)

L. Sinigaglia (Italy)R. V. Thakker (UK)A. Tincani (Italy)

C. Torti (Italy)

SCIENTIFIC COMMITTEE

FACULTY

LOCAL SCIENTIFIC MEMBERSCarlo Bartolozzi

Stefano BombardieriRomano Danesi

Stefano Del PratoOmbretta Di Munno

Alfredo Falcone

Giulio GuidoMichele Lisanti

Giuliano MarianiEnio MartinoCesare SelliPaolo Vitti

SCIENTIFIC SECRETARIATFilomena Cetani, Edda Vignali

Department of Clinical and Experimental Medicine - University of Pisa

10.30 - 11.00 Opening Ceremony

11.00 - 13.00 New Insights in the Pathogenesis of GIO Chairs: A. Angeli (Italy), L. Moro (Italy)11.00 - 11.30 A Mouse Model of Cushing’s Syndrome - R. V. Thakker (UK)11.30 - 12.00 Hypothalamic-pituitary-adrenal Axis and Rheumatic Diseases - M. Cutolo (Italy)12.00 - 12.30 Notch Signal and Osteocytes - E. Canalis (USA)12.30 - 13.00 Role of the Oxidative Stress - M. Almeida (USA)

13.00 - 14.00 Lunch

14.00 - 16.00 Drug-induced Osteoporosis Chairs: G. Bianchi (Italy), R. Rizzoli (Switzerland)14.00 - 14.30 Proton Pump Inhibitors and H2 Receptor Antagonists - J. D. Adachi (Canada)14.30 - 15.00 Selective Seretonin Reuptake Inhibitors and Fractures: an Epidemiologic Perspective - O. Bruyere (Belgium)15.00 - 15.30 Cardiovascular Drugs - G. Mazziotti (Italy)15.30 - 16.00 Antiretroviral Therapy - C. Torti (Italy)

16.00 - 16.30 Coffee Break

16.30 - 18.00 Malignancy and Osteoporosis Chairs: J.P. Bilezikian (USA), G.C. Isaia (Italy)16.30 - 17.00 Aromatase Inhibitors and Breast Cancer - R. Rizzoli (Switzerland)17.00 - 17.30 Androgen Deprivation Therapy and Prostate Cancer - F. Bertoldo (Italy)17.30 - 18.00 Thyroid Cancer and Levothyroxine Therapy - C. Marcocci (Pisa, IT)

18.00 - 19.00 Oral Communications Chair: F. Cetani (Italy)

19.00 - 19.30 GIOSEG General Assembly

Friday, May 31st 2013PROGRAM

08.30 -11.00 Rheumatic and Metabolic Bone Diseases Chairs: S. Bombardieri (Italy), S.R. Goldring (USA)08.30 - 09.00 Systemic Lupus, Autoimmunity and Bone - A. Tincani (Italy)09.00 - 09.30 Biologics and Bone Remodeling in Rheumatoid Arthritis - O. Di Munno (Italy)09.30 - 10.00 Osteoporotic Fractures in Diabetes Mellitus - L. Hofbauer (Germany)10.00 - 10.30 Organ Transplantation and Osteoporosis - S. Giannini (Italy) 10.30 - 11.00 Subclinical Hypercortisolism and Bone - I. Chiodini (Italy)

11.00 - 11.30 Coffee Break

11.30 -13.00 Novel Glucocorticoids Chairs: L. Hofbauer (Germany), G. Lombardi (Italy)11.30 - 12.00 Selective GC Receptor Agonists - M. Rauner (Germany)12.00 - 12.30 Modified Release Glucocorticoids - R. Alten (Germany)12.30 - 13.00 Dual-release Hydrocortisone - A. Nillson (Sweden)

13.00 - 14.00 Lunch

14.00 - 15.30 Guidelines and Algorithms Chairs: J.D. Adachi (Canada), L. Sinigaglia (Italy)14.00 - 15.00 Debate on New ACR vs IOF Guidelines in the Management of Glucocorticoid-induced Osteoporosis: Which One to Follow?

14.00 - 14.30 ACR Guidelines - S. R. Goldring (USA) 14.30 - 15.00 IOF Guidelines - N.C. Harvey (UK)15.00 - 15.30 FRAX Adjustment According to the Dose of Glucocorticoids - S. Adami (Italy)

15.30 - 17.00 Treatment Chairs: S. Minisola (Italy), R. Nuti (Italy)15.30 - 16.00 Clodronate - B. Frediani (Italy)16.00 - 16.30 Medical Therapy of Cushing’s Disease - A. Giustina (Italy)16.30 - 17.00 Glucocorticoid-induced Osteoporosis - J. P. Bilezikian (USA)

17.00 - 17.30 Closing Remarks

Saturday, June 1st 2013

PREVALENCE OF REDUCED BONE MINERAL DENSITY AND FRAGILITY FRACTURES IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUSL. Carli1, C. Tani2,S. Vagnani2,F. Querci2, C. Baldini2,A. Della Rossa2,R. Talarico2,M. Mazzantini2S. Bombardieri2, M. Mosca2, O. Di Munno2

1 Rheumatology Unit of Pisa, Doctorate in Genetics, Oncology and Clinical Medicine University of Siena, Italy. 2 Rheumatology Unit, University of Pisa, Italy

ANALYSIS OF THE ADHERENCE TO THE RECOMMENDATIONS FOR THE MONITORING OF GLUCOCORTICOID-INDUCED OSTEOPOROSIS IN A MONOCENTRIC COHORT OF PA-TIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUSL. Carli1, C. Tani2, C. Baldini2, A. Della Rossa2, A. d’Ascanio2, R. Neri2, M. Cagnoni2, M. Mazzantini2O. Di Munno2, S. Bombardieri2, M. Mosca2

1 Rheumatology Unit of Pisa, Doctorate in Genetics, Oncology and Clinical Medicine University of Siena, Italy. 2 Rheumatology Unit, University of Pisa, Italy

INCIDENCE OF NEW VERTEBRAL FRACTURES AFTER VERTEBROPLASTY IN PATIENTS WITH GLUCOCORTICOID-INDUCED OSTEOPOROSIS: A PROSPECTIVE, CONTROLLED, COHORT STUDYM. Mazzantini1, M. Puglioli2, S. Bombardieri1, O. Di Munno1

1U.O. Reumatologia, Azienda Universitario-Ospedaliera di Pisa, Italy2U.O. Neuroradiologia, Azienda Universitario-Ospedaliera di Pisa, Italy

SPONTANEOUS ADIPOGENESIS IN BONE MARROW DERIVED MESENCHYMAL STROMAL CELLS AFTER CHRONIC TREATMENT WITH GLUCOCORTICOIDSC. Tani, S.Vagnani, L. Carli, F. Querci, M. Mosca, S. BombardieriRheumatology Unit, University of Pisa

ROLE OF BONE MINERAL DENSITY AND ANTIRETROVIRAL THERAPY IN PREDICTING MORPHOMETRIC VERTEBRAL FRACTURES IN PATIENTS WITH HIV INFECTIONT. Porcelli1, E. Quiros-Roldan2, M. Gianizza1, D. Gotti2 , F. Maffezzoni1, G. Mazziotti1, F. Castelli2, A. Giustina1

1Chairs of Endocrinology University of Brescia, Italy2Chairs of Infectious Diseases, University of Brescia, Italy

EFFECT OF SUBCLINICAL CUSHING’S SYNDROME ON BONE MINERAL DENSITYV. Raffaelli, L.Manetti, E. Vignali, F. Bogazzi, C. MarcocciDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

RELANTIONSHIP BETWEEN DIABETES MELLITUS AND SKELETAL FRAGILITY IN PATIENTS EXPOSED TO GLUCOCORTICOID EXCESSG. Mazziotti, I. Karamouzis, I. Patelli, F. Maffezzoni, A. Cristiano, M. Doga, P. Vescovi, A. GiustinaChair of Endocrinology, University of Brescia, Italy; Department of Medicine, Endocrine and Bone Unit, Azienda Ospedaliera Carlo Poma of Mantua, Italy.

ORAL COMMUNICATIONS

On the fertile Tuscan plains where the Arno river flows into the sea, the area around Pisa has been inhabited since Etruscan times, and became a Roman colony in 179 AC. Pisa used to lie directly on the sea, with boats docking at the walls of the main square the Campo dei Miracoli, but the centuries of silt has pushed it further inland.Nothing says Pisa more than its Leaning Tower, part of the Campo dei Miracoli literally, Field of Miracles. Gateway to the Tuscan hills, this medieval city of architectural mas-terpieces goes against type with its young and upbeat feel. Native son Galileo may be long gone but students still come here to study at the prestigious university where he taught. In its heyday Pisa was one of Italy’s most powerful maritime republics. Follow its past in the Romanesque churches, piazzas and palaces that line the winding Arno River through the city to the Tyrrhenian Sea. Pisa suffered terrible bombing damage during World War II, but fortunately a fair amount of its beautiful ancient architecture remains.

Meeting VenueAC Hotel - Via delle Torri, 20 · 56124 Pisa Italy +39 050 575395

Official LanguageThe official language is English (translation is not provided).

CMEThe 8TH International Congress GIO program has received nr. 12 credits by the Italian Educazi-one Continua in Medicina (ECM) for Physician (Medico Chirurgo)Provider: ECM SERVICE srl Via T. Invrea 9/13 16129 Genova

Attendence CertificateAttendance Certificate can be collected at registration desk only at the end of the Meeting.

Website For further information, please visit the official website of the Meeting: www.gioseg.org

PISA

GENERAL INFORMATION

Registration (21% VAT included)€ 363,00 within April 30th - € 423,00 after April 30th - € 181,00 under 35 - FREE Abstract Submitter Under 35. Identity Document (ID) is required for delegates UNDER 35. Registration fee includes: Congress Kit, Certificate of Attendance, Lunch and Coffee Breaks mentioned in program. Registration Form is available on website www.gioseg.org. c/o A.I.C. Asti Incentives & Congressi Piazza San Uomobono, 30 56126 Pisa Italy - Phone +39 050 598808 Fax +39 050 598688

Liability & InsuranceThe registration fees do not include the insurance of participants against personal accidents, sick-ness, cancellations by any party, theft, loss or damage to personal belongings. Participants are advised to take out adequate personal insurance to cover travel, accommodation, cancellation and personal effects.

Commercial ExhibitionThe exhibition will take place in the foyer of the Venue. Exhibitors will have the chance to meet with the delegates.

Cancellation & RefundRequests for refund must be received within April 30th 2013 by email to: gio2013@aicgroup.it All refunds will be sent after the Meeting. No refund will apply for cancellations received after April 30th, 2013

How to reach the Congress VenueBy train Pisa Central Station, 7 km by taxi (cost approx. euro 12,00)

By car Exit “Pisa Nord Est” on highway S.G.C. FI-PI-LI, follow directions for City center, after approx. 1 km you will find the hotel on your left (in the back of an ENI tank station)

By plane Pisa Airport, km 8 by taxi (cost approx. euro 15,00)

Oral Communication GuidelinesTime available for each presentation is 7’ speech and 3’ discussion. Speakers must adhere strictly to the scheduled times according to program. Speakers are kindly requested to use PowerPoint (Windows). The uploading of DVD movies is NOT supported. We recommend using “jpeg” and “tiff” formats for images. Other types of ex-tension will be accepted, provided that they are recognized by PowerPoint.Please download your presentations by using USB pens at least 2 hours before speech at the Slide Center. All Oral Communication Speaker must be registered to the Meeting.

Poster GuidelinesPapers must be posted within Friday, 31st may at 10.00 am. Poster Panel size is 90 cm large x 120 cm high. Please remember (if you haven’t provided yet) that 1st author/presenter should be in order with registration. For further information please contact: gio2013@aicgroup.it

Speakers GuidelinesSpeakers must adhere strictly to the scheduled times according to program. Only computer pro-jection will be available, personal laptops cannot be used.Speakers are kindly requested to use PowerPoint (Windows). The uploading of DVD movies is NOT supported. We recommend using “jpeg” and “tiff” formats for images. Other types of extension will be accepted, provided that they are recognized by PowerPoint. Please download your presentations by using USB pens at least 2 hours before speech at the Slide Center.

By submitting an abstract all author’s agree to transfer all copyrights to the G.I.O.S.E.G.For further information please contact: infogioseg@aicgroup.it or ph +39 050 598808

SCIENTIFIC INFO & GUIDELINES

NOTES

NOTES

patronages

Comune di Pisa

Università di Pisa

Dipartimento di Medicina Clinica e Sperimentale

Azienda Ospedaliero Universitaria Pisana

Azienda USL 5 Pisa

International Osteoporosis Foundation (IOF)

European Society of Endocrinology (ESE)

European Calcified Tissue Society (ECTS)

Società Italiana di Endocrinologia (SIE)

Società Italiana dell’Osteoporosi del Metabolismo Mineralee delle Malattie dello Scheletro (SIOMMMS)

Società Italiana di Reumatologia (SIR)