PROGRAMMA DCSB2015 GIOVEDÌ 24 SETTEMBRE

08:30 — 9:00 Registrazione

SESSIONE I (Chair Roberto Purrello e Roberto Fattorusso) 09:00 — 09:45 Pl1 Enrico Rizzarelli - From Metallome to Metallostasis 09:45 — 10:05 O1 Diego Sbardella - Cisplatin targets proteasomeactivity 10:05 — 10:25 O2 Chiara Nardon - 20S proteasome inhibition by gold(III)-based antitumor agents: from in vitro and in vivo studies to X- ray crystallography 10:25 — 10:45 O3 Grazia Tundo - Dys-regulation of the Ubiquitin Proteasome System in Rett Syndrome 10:45 — 11:05 O4 Alessandro Sinopoli - Inhibiton of Alzheimer’s amyloid-β peptide aggregation and neurotoxicity by the Trehalose conjugated β-sheet breaker peptide Ac-LPFFD-Th 11:05 — 11:30 Coffee break

SESSIONE II (Chair Massimo Coletta) 11:30 — 12:15 Pl2 Anna Bernardi - Design and synthesis of selective glycomimetic antagonists of DC-SIGN 12:15 — 12:35 O5 Domenico Garozzo - Glycomics and Glycoproteomics for Biomarker discovery in Human diseases 12:35 — 12:55 O6 Sara Sattin - Allosteric activation of Hsp90 enzymatic activity and molecular dynamics with glycobenzofurans 12:55 — 13:15 O7 Marta De Zotti - Helical Oligopeptides Inhibiting the VEGF/VEGFR Protein-Protein Interaction for Cancer Therapy 13:15 — 14:30 Pranzo

SESSIONE III (Chair Carla Isernia e Gianluca Fossati) 14:30 — 15:15 Premio Italfarmaco “G. De Santis” - Jussara Amato - “DNA: alternative conformations and their unrevealed biological significance” 15:15 — 15:35 O8 Gennaro Piccialli - In silico driven synthesis of new Tetra-End-Linked DNA aptamers targeting the HIV-1 gp120 15:35 — 15:55 O9 Nunzio Cardullo - Bioinspired neolignans: chemo-enzymatic synthesis and antiproliferative activity 15:55 — 16:15 O10 Domenica Musumeci - Screening and evaluation of putative telomeric G4-binders by the G4-OAS binding assay 16:15 — 16:45 Coffee break

SESSIONE IV (Chair Luca Prodi) 16:45 — 17:30 Pl3 Pierangelo Metrangolo - Halogenation Amplifies Amyloid Self-Assembly 17:30 — 17:50 O11 Agostino Casapullo - Biomolecular Fishing for Calixarene Partners by Chemoproteomics 17:50 — 18:10 O12 Bruno Pagano - G-quadruplexes and their interaction with proteins: new opportunities for drug development 18:10 — 18:30 O13 Antonino Mazzaglia - Supramolecular assemblies based on amphiphilic cyclodextrin/porphyrin complexes as potentially cell-targeted nanotherapeutics 18:30 — 19:30 SESSIONE POSTER 19:30 ASSEMBLEA DEI SOCI 21:00 Cena Sociale VENERDÌ 25 SETTEMBRE

SESSIONE V (Chair Antonio Rosato e Stefano Ciurli) 09:00 — 09:45 Pl4 Stefano Mangani – Integrated platforms for drug discovery campaigns: the role of protein crystallography 09:45 — 10:05 O14 Rita Berisio - Collagen-like proteins as pathogenicity factors of bacterial diseases 10:05 — 10:25 O15 Barbara Zambelli - Metal sensing and selectivity in Ni(II) dependent transcriptional regulators 10:25 — 10:45 O16 Luigi Russo - The molecular recognition mechanism in prokaryotic zinc finger 10:45 — 11:05 O17 Francesco Bellia - Amyloid-binding substances and Abeta-degrading enzymes: how do they interplay? 11:05 — 11:30 Coffee break

SESSIONE VI (Chair Luca D’Andrea) 11:30 — 11:50 O18 Francesco Musiani - Molecular dynamics study on the Fur regulator from H. pylori 11:50 — 12:10 O19 Giampaolo Barone - Host-guest interactions between biomolecules and small molecules: a contribution by Computational Chemistry 12:10 — 12:30 O20 Antonella Paladino - Ligand-based modulation of integrin functional dynamics. 12:30 — 12:50 O21 Martina Pannuzzo - Positional Adjustments Induced by the Membrane Curvature Affect the Fate of Self-Assembling Peptides: A Theoretical and Molecular Dynamics Study 12:50 –– 13:10 O22 Emanuela Iaccarino - SsCEI 4 peptide analogues for the regulation/inhibition of porcine APEH enzyme. 13:10 Conclusione dei lavori