Darunavir/ritonavir
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Reactions 1457 - 22 Jun 2013 ★ S Darunavir/ritonavir Acute demyelinating polyneuropathy (first report) in an elderly patient: case report A 65-year-old HIV-infected man developed acute demyelinating polyneuropathy during treatment with darunavir and ritonavir. The man presented with muscle ache and progressive weakness of his lower limbs; he was totally wheelchair-bound. Darunavir 600mg and ritonavir 100mg twice daily [routes not stated] had been added to his antiretroviral backbone regimen of didanosine and abacavir 3 months earlier, in February 2007. Electromyogram results revealed severe sensory peripheral polyneuropathy. All the man’s medication was withdrawn. His clinical state rapidly deteriorated, and his CD4+ cell count fell. He was treated with empirical antiretrovirals including raltegravir, etravirine and emtricitabine/tenofovir disoproxil fumarate. Three months later, his electromyogram results revealed a normal pattern, with no signs of peripheral neuropathy or myopathy. Author comment: "In this report, we present a case of severe HIV-1-related acute demyelinating polyneuropathy which initiated after new generation PI [protease inhibitor] darunavir/ritonavir was given and resolved after cessation of the drug without the use of immune-based therapies . . . The HIV-related inflammatory neuropathies can be further distinguished into a subtype associated with HIV infection per se and an antiretroviral (ARV) toxic neuropathy associated with the use of ARV agents." Lorber M. A case of possible darunavir/ritonavir-induced peripheral neuropathy: Case description and review of the literature. Journal of the International Association of Providers of AIDS Care 12: 162-165, No. 3, May-Jun 2013. Available from: URL: http://dx.doi.org/10.1177/2325957412471993 - Israel 803088536 » Editorial comment: A search of AdisBase, Medline and Embase did not reveal any previous case reports of polyneuropathy associated with darunavir. The WHO ADR database contained 1 report of polyneuropathy associated with darunavir. 1 Reactions 22 Jun 2013 No. 1457 0114-9954/10/1457-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
Transcript of Darunavir/ritonavir
Reactions 1457 - 22 Jun 2013
★ SDarunavir/ritonavir
Acute demyelinating polyneuropathy (first report) inan elderly patient: case report
A 65-year-old HIV-infected man developed acutedemyelinating polyneuropathy during treatment withdarunavir and ritonavir.
The man presented with muscle ache and progressiveweakness of his lower limbs; he was totally wheelchair-bound.Darunavir 600mg and ritonavir 100mg twice daily [routes notstated] had been added to his antiretroviral backbone regimenof didanosine and abacavir 3 months earlier, in February 2007.Electromyogram results revealed severe sensory peripheralpolyneuropathy.
All the man’s medication was withdrawn. His clinical staterapidly deteriorated, and his CD4+ cell count fell. He wastreated with empirical antiretrovirals including raltegravir,etravirine and emtricitabine/tenofovir disoproxil fumarate.Three months later, his electromyogram results revealed anormal pattern, with no signs of peripheral neuropathy ormyopathy.
Author comment: "In this report, we present a case ofsevere HIV-1-related acute demyelinating polyneuropathywhich initiated after new generation PI [protease inhibitor]darunavir/ritonavir was given and resolved after cessation ofthe drug without the use of immune-based therapies . . . TheHIV-related inflammatory neuropathies can be furtherdistinguished into a subtype associated with HIV infection perse and an antiretroviral (ARV) toxic neuropathy associatedwith the use of ARV agents."Lorber M. A case of possible darunavir/ritonavir-induced peripheral neuropathy:Case description and review of the literature. Journal of the InternationalAssociation of Providers of AIDS Care 12: 162-165, No. 3, May-Jun 2013.Available from: URL: http://dx.doi.org/10.1177/2325957412471993 -Israel 803088536
» Editorial comment: A search of AdisBase, Medline andEmbase did not reveal any previous case reports ofpolyneuropathy associated with darunavir. The WHO ADRdatabase contained 1 report of polyneuropathy associated withdarunavir.
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Reactions 22 Jun 2013 No. 14570114-9954/10/1457-0001/$14.95 Adis © 2010 Springer International Publishing AG. All rights reserved
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