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DIPARTIMENTO DI NEUROLOGIA E PSICHIATRIA CURRICULUM DIDATTICO-‐‑SCIENTIFICO DEL PROF. Giuseppe MECO

DATI PERSONALI Nome e Cognome GIUSEPPE MECO

Luogo e data di nascita: Stato Civile:

Dipartimento

Indirizzo

L’Aquila Neurologia e Psichiatria Viale dell’Università 30 00185 Roma

Telefono uff./lab./mobile 06/4991.4465-‐‑.4460

Fax 06/4991.4460

E-‐‑mail [email protected]

Settore Scientifico-‐‑Disciplinare: MED 26 Orario di Ricevimento: Martedì ore 12-‐‑14; Mercoledì ore 12-‐‑14 ATTUALE POSIZIONE Ø Ricercatore Confermato/Professore Aggregato CARRIERA E TITOLI

1. 1975-‐‑1980 Assegno di studio per formazione didattico-‐‑scientifica 2. Dal 1981 a tutt’oggi Ricercatore Confermato 3. Dal 2003 Professore Aggregato a tutt’oggi 4. Dal 2001 al 2010 Vice-‐‑Presidente CL Fisioterapisti (Ariccia/ASL-‐‑RMH) 5. Dal 2010 a rutt’oggi Presidente CL Fisioterapisti (Ariccia/ASL-‐‑RMH)

ATTIVITA’ DIDATTICA

1. Neurologia CL Fisioterapisti (Ariccia/ASL-‐‑RMH 2. Neurologia CL Audiometristi (Policlinico Umberto I°) 3. Neurologia CL Medicina e Chirurgia D

Fo

tografia formato JPG


ATTIVITA’ SCIENTIFICA (Settori di ricerca di interesse e luoghi di svolgimento delle ricerche, con collaborazioni etc.) I principali argomenti di ricerca sviluppati con continuità temporale nella produzione scientifica sono i seguenti:

1. Malattie degenerative con particolare attenzione alla Malattia di Parkinon ed alle malattie extrapiramidali

2. Neuropsicofarmacologia sperimentale e clinica 3. Neuroepidemiologia e Neurotossicologia

Dal 1995 fa parte del panel su “Environmental neurology and toxicology” della E.F.N.S. Dal 1999 è membro del “Research Group on Parkinsonism and Related Disorders” of the World Federation of Neurology. Membro dell’ Editorial Board di Movement Disorders dal 2009. Svolge la sua attività di ricerca presso il Centro Malattia di Parkinson del Policlinico Umberto I° in collaborazione con centri nazionali ed internazionali. Aderisce al Centro di Ricerca Malattie Sociale (CIMS) “Sapienza” Università di Roma. ATTIVITA’ ASSISTENZIALE (per i settori in cui è prevista) Direttore del Centro Malattia di Parkinson del Policlinico Umberto I° Roma. PUBBLICAZIONI SCIENTIFICHE (max 30 su un totale di…..)

A. Peer reviewed publications of NOME COGNOME: selezionate (ultimi 15 anni) # Riferimento Impact

Factor 1 Morgante L, Colosimo C, Antonini A, Marconi R, Meco G, Pederzoli M, Pontieri

FE, Cicarelli G, Abbruzzese G, Zappulla S, Ramat S, Manfredi M, Bottacchi E, Abrignani M, Berardelli A, Cozzolino A, Paradiso C, De Gaspari D, Morgante F, Barone P; on behalf of the PRIAMO Study Group.

Psychosis associated to Parkinson's disease in the early stages: relevance of cognitive decline and depression.

J Neurol Neurosurg Psychiatry. 2011 Aug 11. 4.791 2 Moreno-López C, Santamaría J, Salamero M, Del Sorbo F, Albanese A, Pellecchia

MT, Barone P, Overeem S, Bloem B, Aarden W, Canesi M, Antonini A, Duerr S, Wenning GK, Poewe W, Rubino A, Meco G, Schneider SA, Bhatia KP, Djaldetti R, Coelho M, Sampaio C, Cochen V, Hellriegel H, Deuschl G, Colosimo C, Marsili L, Gasser T, Tolosa E.

Excessive daytime sleepiness in multiple system atrophy (SLEEMSA study). Arch Neurol. 2011 Feb;68(2):223-30. 6.31 3 Di Battista ME, Giustini P, Bernardi S, Stirpe P, Vanacore N, Meco G


A simplified algorithm may lead to overestimate dementia in PD. A clinical and epidemiological study using criteria for PD-D proposed by the Movement Disorders Task Force.

J Neural Transm. 2011 Apr 10. 2.597 4 Köllensperger M, Geser F, Ndayisaba JP, Boesch S, Seppi K, Ostergaard K, Dupont

E, Cardozo A, Tolosa E, Abele M, Klockgether T, Yekhlef F, Tison F, Daniels C, Deuschl G, Coelho M, Sampaio C, Bozi M, Quinn N, Schrag A, Mathias CJ, Fowler C, Nilsson CF, Widner H, Schimke N, Oertel W, Del Sorbo F, Albanese A, Pellecchia MT, Barone P, Djaldetti R, Colosimo C, Meco G, Gonzalez-Mandly A, Berciano J, Gurevich T, Giladi N, Galitzky M, Rascol O, Kamm C, Gasser T, Siebert U, Poewe W, Wenning GK; EMSA-SG.

Presentation, diagnosis, and management of multiple system atrophy in Europe: final analysis of the European multiple system atrophy registry

Mov Disord. 2010 Nov 15;25(15):2604-12. 4.014 5 Pascale E, Passarelli E, Purcaro C, Vestri AR, Fakeri A, Guglielmi R, Passarelli F,

Meco G. Lack of association between IL-1β, TNF-α, and IL-10 gene polymorphisms and

sporadic Parkinson's disease in an Italian cohort. Acta Neurol Scand. 2010 Sep 29. doi: 10.1111/j.1600-0404.2010.01441.x. [Epub

ahead of print 2.324 6 Ricciardi MC, Sirimarco G, Vicenzini E, Zuco C, Meco G, Di Piero V, Lenzi GL.J Transcranial sonographic findings in Wilson disease. Ultrasound Med. 2010 Jul;29(7):1143-5. 3.15 7 Iacovelli E, Gilio F, Meco G, Fattapposta F, Vanacore N, Brusa L, Giacomelli E,

Gabriele M, Rubino A, Locuratolo N, Iani C, Pichiorri F, Colosimo C, Carbone A, Palleschi G, Inghilleri M

Bladder symptoms assessed with overactive bladder questionnaire in Parkinson's disease

Mov Disord. 2010 Jul 15;25(9):1203-9. 4.014 8 Colosimo C, Morgante L, Antonini A, Barone P, Avarello TP, Bottacchi E, Cannas

A, Ceravolo MG, Ceravolo R, Cicarelli G, Gaglio RM, Giglia L, Iemolo F, Manfredi M, Meco G, Nicoletti A, Pederzoli M, Petrone A, Pisani A, Pontieri FE, Quatrale R, Ramat S, Scala R, Volpe G, Zappulla S, Bentivoglio AR, Stocchi F, Trianni G, Del Dotto P, Simoni L, Marconi R; PRIAMO STUDY GROUP.

Non-motor symptoms in atypical and secondary parkinsonism: the PRIAMO study. J Neurol. 2010 Jan;257(1):5-14. Epub 2009 Aug 9. 2.903 9 Meco G, Stirpe P, Edito F, Purcaro C, Valente M, Bernardi S, Vanacore N. Aripiprazole in L-dopa-induced dyskinesias: a one-year open-label pilot study J Neural Transm. 2009 Jul;116(7):881-4. Epub 2009 May 12. 2.259 10 Barone P, Antonini A, Colosimo C, Marconi R, Morgante L, Avarello TP, Bottacchi

E, Cannas A, Ceravolo G, Ceravolo R, Cicarelli G, Gaglio RM, Giglia RM, Iemolo F, Manfredi M, Meco G, Nicoletti A, Pederzoli M, Petrone A, Pisani A, Pontieri FE, Quatrale R, Ramat S, Scala R, Volpe G, Zappulla S, Bentivoglio AR, Stocchi F, Trianni G, Dotto PD; PRIAMO study group.


The PRIAMO study: A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease.

Mov Disord. 2009 Aug 15;24(11):1641-9. 4.014 11 Di Fonzo A, Fabrizio E, Thomas A, Fincati E, Marconi R, Tinazzi M, Breedveld GJ,

Simons EJ, Chien HF, Ferreira JJ, Horstink MW, Abbruzzese G, Borroni B, Cossu G, Dalla Libera A, Fabbrini G, Guidi M, De Mari M, Lopiano L, Martignoni E, Marini P, Onofrj M, Padovani A, Stocchi F, Toni V, Sampaio C, Barbosa ER, Meco G; Italian Parkinson Genetics Network, Oostra BA, Bonifati V

GIGYF2 mutations are not a frequent cause of familial Parkinson's disease Parkinsonism Relat Disord. 2009 Nov;15(9):703-5. Epub 2009 May 31. 2.406 12 Pascale E, Purcaro C, Passarelli E, Guglielmi R, Vestri AR, Passarelli F, Meco G. Genetic polymorphism of Angiotensin-Converting Enzyme is not associated with the

development of Parkinson's disease and of L-dopa-induced adverse effects. J Neurol Sci. 2009 Jan 15;276(1-2):18-21. Epub 2008 Sep 20. 2.903 13 Healy DG, Falchi M, O'Sullivan SS, Bonifati V, Durr A, Bressman S, Brice A, Aasly

J, Zabetian CP, Goldwurm S, Ferreira JJ, Tolosa E, Kay DM, Klein C, Williams DR, Marras C, Lang AE, Wszolek ZK, Berciano J, Schapira AH, Lynch T, Bhatia KP, Gasser T, Lees AJ, Wood NW; International LRRK2 Consortium.

Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study.

Lancet Neurol. 2008 Jul;7(7):583-90. Epub 2008 Jun 6. 18.06 14 Köllensperger M, Geser F, Seppi K, Stampfer-Kountchev M, Sawires M, Scherfler

C, Boesch S, Mueller J, Koukouni V, Quinn N, Pellecchia MT, Barone P, Schimke N, Dodel R, Oertel W, Dupont E, Østergaard K, Daniels C, Deuschl G, Gurevich T, Giladi N, Coelho M, Sampaio C, Nilsson C, Widner H, Sorbo FD, Albanese A, Cardozo A, Tolosa E, Abele M, Klockgether T, Kamm C, Gasser T, Djaldetti R, Colosimo C, Meco G, Schrag A, Poewe W, Wenning GK; European MSA Study Group.

Red flags for multiple system atrophy. Mov Disord. 2008 Jun 15;23(8):1093-9 4.014 15 Meco G, Rubino A, Caravona N, Valente M. Sexual dysfunction in Parkinson's disease Parkinsonism Relat Disord. 2008 Aug;14(6):451-6. Epub 2008 Mar 3. Review 2.406 16 Fabrizio E, Vanacore N, Valente M, Rubino A, Meco G. High prevalence of extrapyramidal signs and symptoms in a group of Italian dental

technicians. BMC Neurol. 2007 Aug 8;7:24 2.113 17 Di Fonzo A, Chien HF, Socal M, Giraudo S, Tassorelli C, Iliceto G, Fabbrini G,

Marconi R, Fincati E, Abbruzzese G, Marini P, Squitieri F, Horstink MW, Montagna P, Libera AD, Stocchi F, Goldwurm S, Ferreira JJ, Meco G, Martignoni E, Lopiano L, Jardim LB, Oostra BA, Barbosa ER; Italian Parkinson Genetics Network, Bonifati V.

ATP13A2 missense mutations in juvenile parkinsonism and young onset Parkinson disease.


Neurology. 2007 May 8;68(19):1557-62. 8.172 18 Grünewald A, Breedveld GJ, Lohmann-Hedrich K, Rohé CF, König IR, Hagenah J,

Vanacore N, Meco G, Antonini A, Goldwurm S, Lesage S, Dürr A, Binkofski F, Siebner H, Münchau A, Brice A, Oostra BA, Klein C, Bonifati V.

Biological effects of the PINK1 c.1366C>T mutation: implications in Parkinson disease pathogenesis

Neurogenetics.2007 Apr;8(2):103-9. Epub 2007 Jan 12 3.486 19 Meco G, Fabrizio E, Epifanio A, Morgante F, Valente M, Vanacore N, Di Rosa AE,

Morgante L. Levetiracetam in tardive dyskinesia. Clin Neuropharmacol. 2006 Sep-Oct;29(5):265-8. 2.349 20 Meco G, Bernardi S. Antidepressant use in treatment of psychosis with comorbid depression in

Parkinson's disease. Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jan 30;31(1):311-3. Epub 2006

Aug 17 2.823 21 Schrag A, Geser F, Stampfer-Kountchev M, Seppi K, Sawires M, Köllensperger M,

Scherfler C, Quinn N, Pellecchia MT, Barone P, Del Sorbo F, Albanese A, Ostergaard K, Dupont E, Cardozo A, Tolosa E, Nilsson CF, Widner H, Lindvall O, Giladi N, Gurevich T, Daniels C, Deuschl G, Coelho M, Sampaio C, Abele M, Klockgether T, Schimke N, Eggert KM, Oertel W, Djaldetti R, Colosimo C, Meco G, Poewe W, Wenning GK; European MSA-Study Group.

Health-related quality of life in multiple system atrophy. Mov Disord. 2006 Jun;21(6):809-15. 4.014 22 Di Fonzo A, Tassorelli C, De Mari M, Chien HF, Ferreira J, Rohé CF, Riboldazzi G,

Antonini A, Albani G, Mauro A, Marconi R, Abbruzzese G, Lopiano L, Fincati E, Guidi M, Marini P, Stocchi F, Onofrj M, Toni V, Tinazzi M, Fabbrini G, Lamberti P, Vanacore N, Meco G, Leitner P, Uitti RJ, Wszolek ZK, Gasser T, Simons EJ, Breedveld GJ, Goldwurm S, Pezzoli G, Sampaio C, Barbosa E, Martignoni E, Oostra BA, Bonifati V Italian Parkinson's Genetics Network

Comprehensive analysis of the LRRK2 gene in sixty families with Parkinson's disease.

Eur J Hum Genet. 2006 Mar;14(3):322-31. 2.567 23 Goldwurm S, Di Fonzo A, Simons EJ, Rohé CF, Zini M, Canesi M, Tesei S,

Zecchinelli A, Antonini A, Mariani C, Meucci N, Sacilotto G, Sironi F, Salani G, Ferreira J, Chien HF, Fabrizio E, Vanacore N, Dalla Libera A, Stocchi F, Diroma C, Lamberti P, Sampaio C, Meco G, Barbosa E, Bertoli-Avella AM, Breedveld GJ, Oostra BA, Pezzoli G, Bonifati V.

The G6055A (G2019S) mutation in LRRK2 is frequent in both early and late onset Parkinson's disease and originates from a common ancestor.

J Med Genet. 2005 Nov;42(11):e65. 7.037 24 Bonifati V, Rohé CF, Breedveld GJ, Fabrizio E, De Mari M, Tassorelli C, Tavella A,

Marconi R, Nicholl DJ, Chien HF, Fincati E, Abbruzzese G, Marini P, De Gaetano A, Horstink MW, Maat-Kievit JA, Sampaio C, Antonini A, Stocchi F, Montagna P, Toni V, Guidi M, Dalla Libera A, Tinazzi M, De Pandis F, Fabbrini G, Goldwurm S,


de Klein A, Barbosa E, Lopiano L, Martignoni E, Lamberti P, Vanacore N, Meco G, Oostra BA; Italian Parkinson Genetics Network.

Early-onset parkinsonism associated with PINK1 mutations: frequency, genotypes, and phenotypes.

Neurology. 2005 Jul 12;65(1):87-95. 8.17 25 Meco G, Fabrizio E, Epifanio A, Di Raimondo G, Vanacore N, Morgante L. Levetiracetam in L-dopa-induced dyskinesia. Clin Neuropharmacol. 2005 Mar-Apr;28(2):102-3. 2.349 26 Di Fonzo A, Rohé CF, Ferreira J, Chien HF, Vacca L, Stocchi F, Guedes L, Fabrizio

E, Manfredi M, Vanacore N, Goldwurm S, Breedveld G, Sampaio C, Meco G, Barbosa E, Oostra BA, Bonifati V; Italian Parkinson Genetics Network.

A frequent LRRK2 gene mutation associated with autosomal dominant Parkinson's disease.

Lancet. 2005 Jan 29-Feb 4;365(9457):412-5. 33.633 27 Bertoli-Avella AM, Giroud-Benitez JL, Akyol A, Barbosa E, Schaap O, van der

Linde HC, Martignoni E, Lopiano L, Lamberti P, Fincati E, Antonini A, Stocchi F, Montagna P, Squitieri F, Marini P, Abbruzzese G, Fabbrini G, Marconi R, Dalla Libera A, Trianni G, Guidi M, De Gaetano A, Boff Maegawa G, De Leo A, Gallai V, de Rosa G, Vanacore N, Meco G, van Duijn CM, Oostra BA, Heutink P, Bonifati V; Italian Parkinson Genetics Network.

Novel parkin mutations detected in patients with early-onset Parkinson's disease. Mov Disord. 2005 Apr;20(4):424-31. 4.014 28 Pezzella FR, Colosimo C, Vanacore N, Di Rezze S, Chianese M, Fabbrini G, Meco

G. Prevalence and clinical features of hedonistic homeostatic dysregulation in

Parkinson's disease. Mov Disord. 2005 Jan;20(1):77-81. 4.014 29 Vanacore N, Bonifati V, Fabbrini G, Colosimo C, De Michele G, Marconi R, Stocchi

F, Nicholl D, Bonuccelli U, De Mari M, Vieregge P, Meco G; ESGAP Consortium. Case-control study of multiple system atrophy. Mov Disord. 2005 Feb;20(2):158-63 4.014 30 Bonifati V, Rizzu P, van Baren MJ, Schaap O, Breedveld GJ, Krieger E, Dekker MC,

Squitieri F, Ibanez P, Joosse M, van Dongen JW, Vanacore N, van Swieten JC, Brice A,Meco G, van Duijn CM, Oostra BA, Heutink P.

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism.

Science. 2003 Jan 10;299(5604):256-9. Epub 2002 Nov 21. 31.36 LIBRI (max 5)

1 Giuseppe Meco, L’invalidità in Neurologia e Psichiatria, Carocci Editore, 2011 2 Giuseppe Meco, Elementi di Neurologia, 2004, Adelphi Editore.

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