CURRICULUM VITAE

D A T I P E R S O N A L I

Nome e cognome Teresa RinaldiData e luogo di nascita 31 gennaio 1966, RomaCittadinanza ItalianaLingue Inglese e francese

C U R R I C U L U M

1989 Laurea in Scienze Biologiche conseguita presso l’Università degli Studi di Roma "La Sapienza" con il punteggio di 110 e lode.

1990-1992 Periodo di ricerca all’estero, in Francia, nel Laboratorio di Génétique et Biologie Moléculaire, Université Paris sud, Orsay.

1992-1995 Dottorato di Ricerca in Biologia Cellulare e Sviluppo svolto presso il Laboratorio di Chimica delle Fermentazioni e Microbiologia Industriale.

1997 Abilitazione alla professione di biologo.

1995-1997 Thèse de Doctorat (Expression génétique chez les microorganismes) conseguito all'Università Paris Sud, Orsay.

Dal 2000 Ricercatore per il Settore scientifico-disciplinare C09B- Chimica e Biotecnologie delle Fermentazioni, presso la Facoltà di Scienze Matematiche Fisiche e Naturali dell’Università “La Sapienza” di Roma.

2004-2008 Docente del corso di Microbiologia Industriale per la Laurea Triennale in Scienze Biologiche, dell’Università “La Sapienza” di Roma.

Dal 2008 al 2014 Docente del corso di Biotecnologie Microbiche ed Ambientali per la Laurea Triennale in Scienze Biologiche, dell’Università “La Sapienza” di Roma.

Dal 2009 ad oggi Docente del corso di Farmacogenomica per la Laurea Magistrale in Biotecnologie Genomiche Industriali ed ambientali, dell’Università “La Sapienza” di Roma.

Pubblicazioni scientifiche

1) Angela Cirigliano; Alberto Macone; Michele M Bianchi; Simonetta Oliaro Bosso; Gianni Balliano; Rodolfo Negri; Teresa Rinaldi (2019). Ergosterol reductions impairs mitochon-drial DNA maintenance in S.cerevisiae. BBA Molecular and Cell Biology of Lipids. Doi: 10.1016/j.bbalip.2018.12.002.

2) Bramasole, L., Sinha, A., Gurevich, S., Radzinski, M., Klein, Y., Panat, N., ... & Krogan, N. J. (2019). Proteasome lid bridges mitochondrial stress with Cdc53/Cullin1 NEDDyla-tion status. Redox biology, 20, 533-543. Doi: 10.1016/j.redox.2018.11.010.

3) Cirigliano, M. C. Tomassetti, M. Di Pietro, F. Mura, M. L. Maneschi, M. D. Gentili, B. Cardazzo, C. Arrighi, C. Mazzoni, R. Negri and T. Rinaldi. (2018). Calcite moonmilk of microbial origin in the etruscan Tomba degli Scudi in Tarquinia, Italy. Scientific Reports, 8:15839. doi:10.1038/s41598-018-34134-y.

4) Nigro L., Montanari D., Mura F., J. Yasine and Rinaldi T. (2018). A hoard of Nilotic nacreous shells from Egypt to Jericho (Early Bronze II, 3000-2900 BC): Their finding, content and historical archaeological implications" Palestine Exploration Quarterly, 150:2, 110-125. Doi: 10.1080/00310328.2018.1425957.

5) Cirigliano, A., Negri R., Rinaldi T. (2017). Dual-use Molecules from Yeast. Biomedicine & Prevention vol.3 CBRNe safety. Special issue (PART1)-(114). Doi: 10.19252/000000072.

6) Tomassetti, M. C., Cirigliano, A., Arrighi, C., Negri, R., Mura, F., Maneschi, M. L., Gentili M.D., Stirpe M., Mazzoni C., Rinaldi, T. (2017). A role for microbial selection in frescoes’ deterioration in Tomba degli Scudi in Tarquinia, Italy. Scientific Reports, 7: 6027. doi: 10.1038/s41598-017-06169-0.

7) Cirigliano, A., Cenciarelli, O., Malizia, A., Bellecci, C., Gaudio, P., Lioj, M., & Rinaldi, T. (2017). Biological dual-use research and synthetic biology of yeast. Science and engineering ethics, 23(2), 365-374. doi: 10.1007/s11948-016-9774-1.

8) Cirigliano, A., Stirpe, A., Menta, S., Mori, M., Dell’Edera, D., Pick, E., Negri, R., Botta, B. & Rinaldi, T. (2016). Yeast as a tool to select inhibitors of the cullin deneddylating enzyme Csn5. Journal of Enzyme Inhibition and Medicinal Chemistry, 1-6. doi: 10.3109/14756366.2016.1160901.

9) L. De Angelis; T. Rinaldi; A. Cirigliano; C. Bello; M. Reverberi; A. Amaretti; A. Montanari; R. Santomartino; S. Raimondi; A. Gonzalez; M. M. Bianchi (2016). Functional roles of the fatty acid desaturases encoded by KlOLE1, FAD2 and FAD3 in the yeast Kluyveromyces lactis. Microbiology doi: 10.1099/mic.0.000315. doi: 10.1099/mic.0.000315.

10) Rinaldi, T. (2015). “Poppy” yeast. EMBO reports, 16(11), 1410-1410. doi: 10.15252/embr.201541367.

11) Ottaviano, D; Montanari, A; De Angelis, L; Santomartino, R; Visca, A; Brambilla, L; Rinaldi, T; Bello, C; Reverberi, M; Bianchi, M. (2015). Unsaturated fatty acids-dependent linkage between respiration and fermentation revealed by deletion of hypoxic regulatory KlMGA2 gene in the facultative anaerobe-respiratory yeast Kluyveromyces lactis. FEMS Yeast Research. 15(5):fov028. doi: 10.1093/femsyr/fov028.

12) G.M. Ludovici, O. Cenciarelli, V. Gabbarini, M. Carestia, A. Malizia, A. Tamburrini, A. Sassolini, D. Di Giovanni, S. Mancinelli, L. Palombi, P. Gaudio, C. Bellecci & T. Rinaldi (2015). The importance of forensic microbiology in the CBRNe investigation. Defence S&T Technical Bulletin. Vol. 8;2: 153-161.

13) Di Noia, M. A., Todisco, S., Cirigliano, A., Rinaldi, T., Agrimi, G., Iacobazzi, V., & Palmieri, F. (2014). The human SLC25A33 and SLC25A36 genes of solute carrier family

25 encode two mitochondrial pyrimidine nucleotide transporters. Journal of Biological Chemistry, 289(48), 33137-33148. doi: 10.1074/jbc.M114.610808.

14) Livnat-Levanon N, Kevei E, Kleifeld O, Krutauz D, Segref A, Rinaldi T, Erpapazoglou Z, Cohen M, Reis N, Hoppe T, Glickman MH. (2014). Reversible 26S Proteasome Disassembly upon Mitochondrial Stress. Cell Rep. Jun 12;7(5):1371-80. doi: 10.1016/j.celrep.2014.04.030.

15) Raimondi S, Rossi M, Leonardi A, Bianchi MM, Rinaldi T, Amaretti A. (2014). Getting lipids from glycerol: new perspectives on biotechnological exploitation of Candida freyschussii. Microb Cell Fact. Jun 7;13:83. doi: 10.1186/1475-2859-13-83.

16) Mannironi C, Proietto M, Bufalieri F, Cundari E, Alagia A, Danovska S, Rinaldi T, Famiglini V, Coluccia A, La Regina G, Silvestri R, Negri R. (2014). An High-Throughput In Vivo Screening System to Select H3K4-Specific Histone Demethylase Inhibitors. PLoS One. Jan 29;9(1):e86002. doi: 10.1371/journal.pone.0086002.

17) Licursi, Valerio; Salvi, Chiara; De Cesare, Virginia; Rinaldi, Teresa; Mattei, Benedetta; Fabbri, Claudia; Serino, Giovanna; Bramasole, Laylan; Zimbler, Jacob; Pick, Elah; Barnes, Brett; Bard, Martin; Negri, Rodolfo. (2014). The Cop9 signalosome is involved in the regulation of lipid metabolism and of transition metals uptake in S. cerevisiae. FEBS J. Jan;281(1):175-90. doi: 10.1111/febs.12584. Epub 2013 Nov 25. doi: 10.1111/febs.12584.

18) Michela Esposito, Simonetta Piatti, Line Hofmann, Laura Frontali, Agnès Delahodde, Teresa Rinaldi. (2011). Analysis of the rpn11-m1 proteasomal mutant reveals connection between cell cycle and mitochondrial biogenesis. FEMS Yeast Res. 11(1):60-71. doi: 10.1111/j.1567-1364.2010.00690.x.

19) Teresa Rinaldi, Cristina Dallabona, Ileana Ferrero, Laura Frontali & Monique Bolotin-Fukuhara. (2010). Mitochondrial diseases and the role of the yeast models. Yeast FEMS Research 10:1006-22. doi: 10.1111/j.1567-1364.2010.00685.x.

20) Line Hofmann, Rémy Saunier, Raynald Cossard, Michela Esposito, Teresa Rinaldi and Agnès Delahodde. (2009). A non-proteolytic activity of the proteasome controls fission of organelles in yeast. J. of Cell Science 122: 3673-3683. doi: 10.1242/jcs.050229.

21) Teresa Rinaldi, Line Hofmann, Alessia Gambadoro, Raynald Cossard, Nurit Livnat-Levanon, Michael Glickman, Laura Frontali and Agnès Delahodde. (2008). Dissection of the carboxy terminal of the Rpn11 essential proteasomal protein: contribution to mitochondrial structure and function in Saccharomyces cerevisiae. Mol. Bio. Cell 19: 1022-1031. Doi: 10.1091/mbc.E07-07-0717.

22) Teresa Rinaldi, Elah Pick, Alessia Gambadoro, Stefania Zilli, Vered Maytal-Kivity, Laura Frontali and Michael H. Glickman. (2004). Participation of the proteasomal lid subunit Rpn11 in mitochondrial morphology and function is mapped to a distinct C-terminal domain. Biochem. J. 380: 1-11. DOI: 10.1042/BJ20040008.

23) T.Rinaldi, A. Gambadoro, S. Francisci and L. Frontali. (2003). Nucleo-mitochondrial interactions in Saccharomyces cerevisiae: characterization of a nuclear gene suppressing a defect in mitochondrial tRNAAsp processing. Gene 303:63-68.

24) Feuermann M., Francisci S., Rinaldi T., De Luca C., Rohou H., Frontali L and Bolotin-Fukuhara M (2003). The Yeast counterparts of human ‘MELAS’ mutations cause mitochondrial dysfunction which can be rescued by overexpression of the mitochondrial translation factor EF-Tu. Embo Reports 4:53-58.

25) Rinaldi, T., Ricordy R., Bolotin-Fukuhara, M., Frontali, L. (2002). Mitochondrial effects of the pleiotropic proteasomal mutation mpr1/rpn11: uncoupling from cell cycle defects in extragenic revertants Gene 286:43-51.

26) Rohou, H., Francisci, S., Rinaldi, T., Frontali, L., and Bolotin-Fukuhara, M. (2001). Reintrodution of a characterized mit tRNA glycine mutation into yeast mitochondria provides a new tool for the study of human neurodegenerative diseases. Yeast 18:219-227.

27) Rinaldi, T., Ricci, C., Porro, D., Bolotin-Fukuhara, M. and Frontali, L. (1998). A mutation in a novel yeast proteasomal gene produces a cell cycle arrest, overreplication of nuclear and mitochondrial DNA and an altered mitochondrial morphology. Mol. Biol Cell 9: 2917-2931. DOI: 10.1091/mbc.9.10.2917. 62

28) Tettelin, H., Agostoni, M. C., Albermann, K., Albers, M., Arroyo, J., Backes, U., … Rinaldi, T., ... & Bruschi, C. V. (1997). The nucleotide sequence of Saccharomyces cerevisiae chromosome VII. Nature, 387(6632 Suppl), 81-84.

29) Rinaldi, T., Lande, R., Bolotin-Fukuhara, M. and Frontali, L. (1997). Additional copies of the Ef-Tu and Aspartyl-tRNA synthetase genes can compensate a mutation affecting the maturation of the mitochondrial tRNAAsp. Curr. Gen. 31: 494-496.

30) Mazzoni,C., Ruzzi, M., Rinaldi, T., Solinas, F., Montebove, F. and Frontali, L. (1997). Sequence analysis of a 10,5 kb DNA fragment from the yeast chromosome VII reveals the presence of three new open reading frames and of a tRNAThr gene. Yeast 13: 369-372. 3

31) Cardazzo,B., Rinaldi,T., Frontali,L., Carignani,G. and Palleschi,C. (1997). Evolution of mitochondrial genomes in yeast: a study of mitochondrial divergence in two closely related species, Saccharomyces douglasii and Saccharomyces cerevisiae. Mol. Biol. Evol. 14 (2): 200-204.

32) Rinaldi, T., Bolotin-Fukuhara, M. and Frontali, L. (1995). A Saccharomyces cerevisiae gene essential for viability has been conserved in evolution. Gene 160:135-136. DOI: 10.1016/0378-1119(95)00212-O. 16

33) Rinaldi,T., Palleschi,C., Cardazzo,B., Francisci,S., Zennaro,E., Lorenzetti,S., Carignani,G., Frontali,L. (1995). Nucleo-cytoplasmic interactions in the expression of mitochondrial tRNA genes in yeast. Progress in Cell Research Vol. 5: 173-176.

34) Rinaldi, T., Francisci, S., Zennaro, E., Frontali, L. and Bolotin-Fukuhara, M. (1994). Suppression of a mitochondrial point mutation in a tRNA gene can cast light on the mechanisms of 3' end processing. Curr. Gen. 25: 451-455. Doi: 10.1007/BF00351785 11

35) Rinaldi,T., Valens,M. and Bolotin-Fukuhara,M. (1993). Yeast mitochondrial translation: nuclear genes involved in the expression of the mitochondrial genome. NATO/ASI series Vol H71 Protein synthesis and targeting in yeast. Edited by A.J.P. Brown, M.F.Tuite and J. E. G. McCarthy.

36) Valens,M., Rinaldi,T., Daignan-Fornier,B., Bolotin-Fukuhara,M. (1991). Identification of nuclear genes which participate to mitochondrial translation in Saccharomyces cerevisiae. Biochimie 73: 1525-1532.

37) Tian,G.L., Macadre,C., Kruszewska,A., Szczesniak,B., Ragnini,A., Grisanti,P., Rinaldi,T., Palleschi,C., Frontali,L., Slonimski,P.P. and Lazowska,J. (1991). Incipient mitochondrial evolution in yeasts. 1. The physical map and gene order of Saccharomyces douglasii mitochondrial DNA discloses a traslocation of a segment of 15,000 base-pares and the presence of new introns in comparison with Saccharomyces cerevisiae. J.Mol.Biol. 218: 735-746.

38) Ragnini,A., Grisanti,P., Rinaldi,T., Frontali,L. and Palleschi,C. (1991). Mitochondrial genome of Saccharomyces douglasii: genes coding for components of the protein synthetic apparatus. Curr. Gen. 19: 169-174.

39) Francisci,S., Frontali,L., Grisanti,P., Palleschi,C., Ragnini,A., Rinaldi,T., Wilson,C., Zennaro,E. (1990). Genome organization and nucleocytoplasmic interactions in the expression of mitochondrial tRNA genes in yeast. In: Structure, function and biogenesis of energy transfer systems. pp 187-192. Editors: Quagliariello,E., Papa,S., Palmieri,F., Saccone,C.