Post on 28-Sep-2020
CNAO (Centro Nazionale di Adroterapia Oncologica)CNAO (Centro Nazionale di Adroterapia Oncologica)Attivita’ della Sezione di MilanoAttivita’ della Sezione di Milano
LASA 5.07.2007 C. De Martinis Attivita’ INFN-MI 2007/20081
L’adroterapia consente di trattare casi “difficili”L’adroterapia consente di trattare casi “difficili”
VANTAGGI UNIVERSALMENTE RICONOSCIUTIVANTAGGI UNIVERSALMENTE RICONOSCIUTIV N GGI UNIVERS LMEN E RI ONOS IU IV N GGI UNIVERS LMEN E RI ONOS IU I
- risparmio dei tessuti sani circostanti
- migliore conformazione al volume tumorale
TUMORI RADIORESISTENTI
-maggiore efficacia biologica degli ioni 12C rispetto a : radioterapia convenzionale (ACCERTATA)
LASA 5.07.2007 C. De Martinis Attivita’ INFN-MI 2007/20083
p ( E )protoni (IPOTIZZATA, in attesa di validazione clinica )
Vantaggio macroscopico dell’adroterapiVantaggio macroscopico dell’adroterapi
Per il controlloPer il controllodei tumoridei tumori
radioresistentiradioresistenti 25 cm25 cmradioresistentiradioresistentiioni carbonio
400 MeV*A
25 cmTumour
target
25 cmVolume
tumorale
protoni 200 MeV
Beam of hadronsthat slows down in matter
Fasci di adroniche rallentano nei tessuti
Photons Protons10 MVX rays
protonscarbon ionsPhotons Protons
10 MVraggi X
protoniioni carbonio
Confronto tra fasci singoli
LASA 5.07.2007 C. De Martinis Attivita’ INFN-MI 2007/20084
LASA 5.07.2007 C. De Martinis Attivita’ INFN-MI 2007/20086
The CNAO The CNAO FF
The synchrotron
Injector by LNL
RF-Cavity by Sez. Mi
Ion sources by LNS
Magnets,PS,vacuumtech plants Rprot
by LNS
tech.plants,Rprot. Engineerig by LNF
Vertical magnet and
LASA 5.07.2007 C. De Martinis Attivita’ INFN-MI 2007/20088
Monitoring ,scanning systems by Sez. To
Vert
gscanning magnets by Sez. Ge
Power Supply for
DC Bias of VITROVAC
0 70V d 0 50CAVITY
0-70V dc, 0-50
RF OUTAnode Power Supply
12kV dc, 10 A
Screen Grid Power Suplly
1500V dc, 10 A12kV dc, 10 A
THALES RS 1084 CJ
Control Grid Power Supply
600V dc 0 6 A
RF IN
600V dc, 0.6 A
Filament Power Supply
0-12 V, 200A, 50HzRF Driver AMPLIFIER
13 luglio 2007 C. De Martinis INFN-MI attivita' 2007 12
LASA 5.07.2007 C. De Martinis Attivita’ INFN-MI 2007/200813
LASA 5.07.2007 C. De Martinis Attivita’ INFN-MI 2007/200814
AchievementsAchievements
The RF vacuum chamber has The RF vacuum chamber has been completely disassembled in order to insert two additional Vitrovac disks ( this should permit to reach the should permit to reach the lower frequency of 300 kHz)
LASA 5.07.2007 C. De Martinis Attivita’ INFN-MI 2007/200816
Frequency range 300 kHz - 4.0 MHz
RF Specifications (as per 30/07/05)RF Specifications (as per 30/07/05) AchievementsAchievements
Max error and resolution on frequency
10 Hz
Maximum rate of change of frequency 7 MHz/s
Vgap range 10 V – 3 kV
Max error and resolution on Vgap 1%
Maximum rate of change of Vgap 20 kV/s
Noise & perturbation on Vgap signal To satisfy the requirements on the maximum error on the Vgap, th i h ld b l th 1%the noise should be less than 1%.
Preliminary measurements have shown noise of about 2.5 % (at 1 MHz and 400 V)
Phase stability required 0.1°
Phase of the signals at the input of the driver amplifier 180° 0 1°Phase of the signals at the input of the driver amplifier 180 0.1
Detuning phase error 6° max (stability should be within 0.5°)
Response time of Vitrovac ?
Response time of Vitrovac Power Supply ?
Input range of the Vitrovac Power Supply 0-10 V
Input range of the driver amplifier 0-10 V
Acceleration Time Protons, 7 to 60 MeV: 270 msProtons, 7 to 250 MeV: 482 msC 7 to 120 MeV: 490 ms
LASA 5.07.2007 C. De Martinis Attivita’ INFN-MI 2007/200819
C, 7 to 120 MeV: 490 msC, 7to 400 MeV: 734 ms
AchievementsAchievementsRF cycles definition
C b I (400M V) Carbon Ions (400MeV) 3.0 3000
Trap
ping Acceleration Extraction End
2.0
2.5
2000
2500Phase jump
1.5
Volta
ge [k
V]
1500
requ
ency
[kH
z]
0 5
1.0
500
1000
Fr
0.0
0.5
0 200 400 600 800 1000 1200 1400 1600 18000
500VoltageFrequency
LASA 5.07.2007 C. De Martinis Attivita’ INFN-MI 2007/200820
Time [ms]
Cavita’ RF
C. De Martinis INFN-MI attivita' 2007 281 m