Precision medicine: dal genoma all'esposoma

PRECISION MEDICINEdal genoma all’esposoma

Roberto Mollica

Bergamo, 14 giugno 2016

SERT 3 – ATS Metropolitana di Milano

http://www.asl.milano.it/Default.aspx

PARADIGM SHIFT #3Precision medicine System medicine

PARADIMG SHIFT #2Big data Analytics

PARADIGM SHIFT #1Omran Omics

Una scienza omica studia un argomento il cui suffisso termina in -oma. Per questa ragione, la trascrittomica studia il trascrittoma, la genomica il genoma, la proteinomica il proteoma e via dicendo.

THE NEED OF INVENTING “OMICS”The need to create these words rose from the need to study holistic or the totality of the biology of the systems (systems biology).

http://www.google.it/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&ved=0ahUKEwjE-oDs54bNAhXKOxoKHaSZDg0QjRwIBw&url=http://journal.frontiersin.org/article/10.3389/fpls.2014.00244/full&psig=AFQjCNFdkFo0FClwg6Pn8saMgOgygUWGAQ&ust=1464869905679334

http://www.google.it/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&ved=0ahUKEwiItKPwx6TNAhWTDRoKHdVFA08QjRwIBw&url=http://bitesizebio.com/24629/learn-omics-what-is-that-omics-i-keep-stumbling-upon/&psig=AFQjCNHv6ShhJqVWv2VYr74yTzGTaLg0Iw&ust=1465892041047265

Phenomics

Dati clinici ~10%Professionisti della salute

Dati genetici ~30%Laboratorio

Dati esogeni ~60%Prodotti da clienti

“Health Policy Brief: The Relative Contribution of Multiple Determinants to Health Outcomes,” Health Affairs, August 21, 2014.

The bands biometric sensors monitor tangible metrics such as moods, happiness, stress and even fertility tracking. The standard features of tracking fitness, activity, and sleep patterns are also present, making this wearable tech a gateway into both mind and body.


Catena del valore dei dati personali

Dal “produttore” al “consumatore/beneficiario”

Big Data management by Analytics

Big Data and the paradigm shiftNo longer we will pool data from individuals to predict

what happens at the population level.

Instead, population data will be so comprehensive that it will accurately predict what happens to an individual.

Om

ics

Schema semplificato di organizzazione sistemica del vivente

AbstractThe National Institutes of Health's (NIH) commitment to improving health outcomes for women and men through rigorous science has been compromised by the lack of basic science evidence obtained from female animals. To correct this limitation, in June 2015 the NIH announced expectations that "sex," as a biological variable, be included into research design and analysis in studies of vertebrate animals and humans (NOT-OD-15-102). Scientists must take the responsibility to implement this directive. However, in doing so, there is a risk that attention could be restricted to only studies of direct comparison between female/women and male/men. By contrast, understanding how sex influences health and disease needs to take a programmatic approach that includes the study of sex-specific conditions. A programmatic approach will assure the advancement of knowledge to improve women's health.

Suggestion from Pristipino C.

http://www.google.it/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=0ahUKEwjll_a_s5rNAhXFrRoKHeHRDUsQjRwIBw&url=http://www.giocattolivecchi.com/Forum_detail.aspx?t%3D0%26id_d%3D1201520%26p%3D1&bvm=bv.124088155,d.d2s&psig=AFQjCNEE9e9wl8ingnTdz39fPYV8Lr6BbA&ust=1465543010181526

Diseasoma (x..ome)

System medicine

https://www.google.it/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=0ahUKEwjA6vPumoTNAhVHvRQKHf7aCf4QjRwIBw&url=https://twitter.com/hashtag/diseasoma&bvm=bv.123325700,d.d24&psig=AFQjCNFm-MXezBT1Cz3wT8LtTEmP1wBagg&ust=1464780491120747

Average patient«one-size-fits-all»

Bio-psycho-socio-environmentalapproach

http://www.google.it/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=0ahUKEwjjycXmx5rNAhUFOhoKHXmtCGYQjRwIBw&url=http://www.dfmmolinari.com/PAGMICRO/biolog.html&bvm=bv.124088155,d.d2s&psig=AFQjCNHQF-QEjnreGI4DS0TmV9UxE4EJZA&ust=1465548506830020

https://www.google.it/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=0ahUKEwiE1tqayJrNAhWClxoKHbCYCigQjRwIBw&url=https://helix.northwestern.edu/blog/2013/11/braintools-functional-neuroimaging&bvm=bv.124088155,d.d2s&psig=AFQjCNFvm4E8GQ1h92y4WxbaRwC-qBDs3A&ust=1465548590643838

http://www.google.it/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=0ahUKEwiyrLXYyJrNAhUFfhoKHUuJATQQjRwIBw&url=http://alimentazionebambini.e-coop.it/la-tata-consiglia/mio-figlio-e-timido-come-posso-aiutarlo-socializzare/&psig=AFQjCNEJ2KmyqUwvoVrdwd4AcIP4zzUS2g&ust=1465548728071396

http://www.google.it/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=0ahUKEwixgrfIyZrNAhWHOBoKHSFPD5AQjRwIBw&url=http://it.123rf.com/clipart-vettori/ambiente.html&bvm=bv.124088155,d.d2s&psig=AFQjCNH4u5MKN1qCLq2s3fV5vSABsJKOpQ&ust=1465548923427839

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"YOU CAN'T DO TODAY'S JOBWITH YESTERDAY'S METHODSAND BE IN BUSINESS TOMORROW"

Addiction and gender. Bergamo 14 giugno 2016

Roberto Mollica

Precision medicine: dal genoma all'esposoma

Healthcare

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