OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship...
Transcript of OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship...
![Page 1: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/1.jpg)
GrazianoCeresiniSSEndocrinologiaMetabolicaGeriatrica
UniversitàdiParmaAzOspedaliero-UniversitariadiParma
ILRUOLODELLAVITAMINAD
OSTEOPOROSIPERNONOSTEOPOROLOGI
![Page 2: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/2.jpg)
D3:colecalciferoloD2:ergocalciferolo25(OH)D3:calcifediolo1,25(OH)2D3:calcitriolo
![Page 3: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/3.jpg)
LivellicircolanJdivitaminaD
• LivelliSufficienJ:>30ng/mL(75nmol/L)• Insufficienza:20-30ng/mL(50-75nmol/L)
• Carenza:<20ng/mL(<50nmol/L)
![Page 4: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/4.jpg)
VitaminaDedosso:studiosservazionali
![Page 5: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/5.jpg)
AmJMed2004
VitaminDandBMIinYOUNGERADULTS
![Page 6: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/6.jpg)
AmJMed2004
VitaminDandBMIinOLDERADULTS
![Page 7: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/7.jpg)
![Page 8: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/8.jpg)
![Page 9: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/9.jpg)
![Page 10: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/10.jpg)
![Page 11: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/11.jpg)
![Page 12: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/12.jpg)
Prieto-Alhambraetal,2014
![Page 13: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/13.jpg)
VitaminaDedosso:studidiintervento
![Page 14: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/14.jpg)
JNutr2015
![Page 15: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/15.jpg)
![Page 16: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/16.jpg)
Bishoff-FerrarietalArchInternMed,2009
![Page 17: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/17.jpg)
![Page 18: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/18.jpg)
«VitaminDaloneisunlikelytopreventfracturesinolderpeople.SupplementsofvitaminDandcalciummaypreventhiporanytypeoffracture»
![Page 19: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/19.jpg)
• Difficoltànelconfrontotraglistudi:
GeneJcadipopolazione
Biasdiselezione
METODODIDOSAGGIODELLAVITD
![Page 20: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/20.jpg)
Glucosemetabolism
![Page 21: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/21.jpg)
![Page 22: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/22.jpg)
Sayed-HassanRetal,2014
RelaJonshipbetweenPTHandVitaminD
![Page 23: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/23.jpg)
JAMAPediatrics,2014
![Page 24: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/24.jpg)
RelaJonshipbetweenVitaminDandPTHinelderlysubjects
MelinAetal,2014
![Page 25: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/25.jpg)
0
10
20
30
40
50
60
70
80
1 2
PTHpg/mL(M
±SE)
Età<65aa Età≥65aa
LivellicircolanJdiPTHinsoggeigiovaniedanzianiconcarenzadiVitD
![Page 26: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/26.jpg)
![Page 27: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/27.jpg)
Bishoff-Ferrarietal2009
![Page 28: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/28.jpg)
![Page 29: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/29.jpg)
![Page 30: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/30.jpg)
![Page 31: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/31.jpg)
![Page 32: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/32.jpg)
TrajamentoconVitaminaDnell’osteoporosi
![Page 33: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/33.jpg)
![Page 34: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/34.jpg)
![Page 35: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/35.jpg)
![Page 36: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/36.jpg)
![Page 37: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/37.jpg)
![Page 38: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/38.jpg)
Standard recommendations for most postmenopausal
women with osteoporosis support a total calcium intake of
1000 to 1500 mg per day (through diet, supplements, or
both) and a total vitamin D intake of 600 to 800 IU per
day.
January,2016
![Page 39: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/39.jpg)
QualeVitaminaDuJlizzare?
• D2:ergocalciferolo• D3:colecalciferolo• 25(OH)D3:calcifediolo
![Page 40: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/40.jpg)
![Page 41: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/41.jpg)
Variazioni plasmatiche di 25OHD in pazienti trattate con calcifediolo o colecalciferolo
Bischoff-Ferrari HA et al, 2012
![Page 42: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/42.jpg)
Variazioni plasmatiche di PTH in pazienti trattate con calcifediolo o colecalciferolo
Bischoff-Ferrari HA et al, 2012
![Page 43: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/43.jpg)
Variazioni della pressione arteriosa sistolica in pazienti trattate con calcifediolo o colecalciferolo
Bischoff-Ferrari HA et al, 2012
![Page 44: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/44.jpg)
![Page 45: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/45.jpg)
![Page 46: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/46.jpg)
![Page 47: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/47.jpg)
Camozzietal,2016
![Page 48: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/48.jpg)
JAMA Intern Med, 2016
![Page 49: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/49.jpg)
![Page 50: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/50.jpg)
![Page 51: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/51.jpg)
Rossini et al J Clin Endocrinol Metab 2012)
![Page 52: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/52.jpg)
TrajamentoconVitaminaDnell’osteoporosi
ElemenJdaconsiderare• CarajerisJchedelpaziente(possibilecarenzadiVitD–
dosaggioemaJco?)• Dose:inmedia,600-800U/die• (Obieivo:portarelaconcentrazionediVitDalivellidi
sufficienza)• Aderenzaallarestanteterapiaincasodiconcomitante
trajamento• CarajerisJchedelpreparatodiVitDchesiintendeuJlizzare• Compliancedelpaziente• SJledivitadelpaziente-anchenell’anziano
![Page 53: OSTEOPOROSI PER NON OSTEOPOROLOGI IL RUOLO DELLA …€¦ · Sayed-Hassan R et al, 2014 Relaonship between PTH and Vitamin D JAMA Pediatrics, 2014 Relaonship between Vitamin D and](https://reader031.fdocumenti.com/reader031/viewer/2022011909/5f6c6fe9542b424e70152874/html5/thumbnails/53.jpg)