I S T I T U T O DI R I C E R C A " A L B E R T O SORTI

I D R A S

M e d i c i n a e B i o l o g i a M e t a m o 1 e c o 1 a r e

Diret tore: Dott . M a s s i m o C i t ro

PRESENTATION TO "6TH INTERSCIENCE WORLD CONFERENCE ON INFLAJT1ATI0N, ANTIRHEUdATICS, ANALGESIA IrtllNCnCOULATCRS" GENEVA, 28-30 MARCH 1995.

ALTHOUGH SOME RESEARCHERS PRETEND TO BE THE INVENTORS OF THE METHODIC

WE PRESENT ,WE WERE THE FIRST IN THE WORLD TO THEORIZE,INVESTIGATE

AND PUBLISH (CURO, 1990) THE FIRST PHARMACOLOGICAL FREQUENCY

TRANSFERING, WE CALLED TFF.

THE EFFECTIVENESS OF TFF PROVES THE EXISTANCE OF

M.I.S. (METAHOLECULAR INFORMED SIGNALS) SPONTANEOUSLY EMITTED

BY EVERY SUBSTANCE AND THAT WE THEORIZED.

OUR INSTITUTE IS AVAILABLE TO COOPERATE WITH OTHER INSTITUTES

IN THIS RESEARCH BECAUSE THESE STUDIES ARE ONLY AT THE BEGINNING

AND HAVE TO BE MORE INVESTIGATED.

WE THINK WE OPENED A DOOR ON A NEW DIMENSION THAT IS UNKNOWN TILL NOW

AND WE THINK TO BE AT THE BEGINNING OF A BIG REVOLUTION IN

PHYSICS, BlOCHEMISTRY,BlOLOGY AND HUMAN KNOWLEDGE.

MASSIMO CITRO

10122 T o r i n o - I ta l ia - V i a Passalacqua, 19 - Te l . e Fax ( O l i ) 53 52 52

N O N M O L E C U L A R I N F O R M E D S I G N A L S C O M I N G F R O M D R U G S : P O S S I B L E A P P L I C A T I O N I N A N T I - I N F L A M M A T O R Y T H E R A P Y . CITRO M, CONROTTO R, G O N E L L A A , VINATTIERI C, Istituto di Ricerca " A . Sorti" (IDRAS), Torino, Italia

I N T R O D U C T I O N

Wè assume the existance of specific non molecular informed signals coming from ali substances and especially front drugs (5,7). On the basis of prior experiences in the field of acupuncture, we have conceived and patented a process that allows to catch such signals, to transmit them to a subject or to imprint them on water. Water activated in such way acquires the pharmacologic properties of the yielding substance and it reproduces its effects without ics admlnistration (1,2). We have called this method T F F (Trasferimento Farmacologico Frequenziale) that is, Pharmacologic Frequency Transfer.

C A S I S T I C AND METHODS

Since 1990, we have gathered severa! clinic cases with TFF from drugs of different classes. We have observed therapeutic responses to TFF made from: antibiotics, anti-inflammatories, analgesics, benzodiazepine, bronchodilators, progestin, oestroprogestin associations, hormones, antihistaminics, antitossives, gastric motility regùlators and synthetic opiates. This study includes a group of 89 patients aged between 20 and 75, that we have observed from May 1990 and March 1995. The patients have been treated with TFF prepared with anti-inflammatories and analgesics. We operate pharmacologic frequency transfers (TFF) using a particular amplifier ( M O R A III200, Firma MEDTRON1K, Friesenheim, Germany) with a selectable gain from 1 to 40 and with a post amplifier x l 2 (gain from 1 to 480) (Fig. 1). It is provided with: an entry cable-connected to a brass celi, in which the phial containing the drug to be transferred is to be placed, an exit cable-connected to an identica! celi containing a glass bottle (or phial) of water (or water and ethanol, or a physiologic solution) to be activated and a second exit cable-connected to a brass electrode directly in contact with the patient or with the receiving biological system (Fig. 2, 3). The informatìon is transmitted along the copper cables isolated with P V C , bayonet coupling. The apparatus is a large band amplifier with minimum frequency distortion, very low phase shift during the transfer and it is capable of amplifying ali possible frequencies keeping their width unchanged. Once it is on, the apparatus, which works by means of accumulators, intercepts and amplifies the signals coming from the entry, including the drug's specific ones, and it tranfers them to the exit with a periodism of 7 seconds of activity and 3 of pause for 15 minutes. Water activated in such way can be given sublingually or parenterally (IM. SC. IV.) and it reproduces the pharmacologic action of the drug of which it has memorized the signal.

MORA IH200 - MEDTR0NIK Fig.2 T F F

MB óeóo ©eoo

a

TRASFERIMENTO FARMACOLOGICO FREQUENZIALE

( P H A R M A C O L O G I C A L F R E Q U E N C Y T R A N S F E R )

O U T P U T (WATER) INPUT (DRUG)

Fig.1

A M P L I PIER

(Poster presentedat the '6th Interscience 'WorldConfennce on Inf[ammattiti, Qineva, March 28-30 , 1335.

R E S U L T S We observed therapeutic response with reduction or disappearence of pain (we used the Vaona scale, from 0 to 11, as a reference) in 66 out of the 89 patients treated (74%) in the remaining 23 cases there has been no response (26%) (Tab.l). None of the patients subject to TFF treatment has ever reported the appearence of side effects. As for the positive cases, 65% of them were treated with T F F of 4 drugs (Tenoxicam 15 cases, Noramidopirina 11 cases, Diclofenac 9 cases and Naproxene 8 cases). The percentage of positivity has been evaluated (Tenoxicam 67%, Noramidopirina 82%, Diclofenac 78%, Naproxene 62.5%) in a 62.5%-82% range (72% average) to which also the percentage of positive cases belongs.

Tab. 1 1 ) DICLOFENAC (TFF08)- HeraxThoidal pain 2) DICLOFENAC (TFF09)- Back pain 3) DICLOFENAC (TFF41)- Shoulder pain 4) DICLOFENAC (TFF49)- Costai pain 5) DICLOFENAC (TFPU8)- Dyamcnotrhua 6) DICLOFENAC (TFF90)- Back pam 7) DICLOFENAC (TFF103)- Arthralgia 8) TENOXICAM (TFF10)- Coxalgy 9) TENOXICAM (TFP11)- Ceivical pam 10) TENOXICAM (TFP28)- Back pam 11) TENOXICAM (TFF40)- Scapulalgy 12) TENOXICAM (TFF68)- Ccphalea 13) TENOXICAM (TFF69)- Brachialgy 14) TENOXICAM (TFF70)- Tendiniti. 15) TENOXICAM (TFF95)- Psoriasi Arthritii 16) TENOXICAM CTFF112)- Scapulalgy 17) TENOXICAM (TFF100)- Gengiviti* 18) KETOPROFENE (TFF84)- Back pain 19) KETOPROFENE (TFF12)- Sciatica 20) KETOPROFENE (TFF108)- DysmcixxThea 21) NAPROXENE (TFF80)- Ccphalea 22) NAPROXENE (TFF60)- Ccphalea

CASES WITH TERAPEUTIC 23) NAPROXENE (TPF46> Ccphalea 24) NAPROXENE (TFF96> Ccphalea 23) NAPROXENE (TFF110)- Ncuralgia 26) DBFLAZACORT (TFF89 y Arthralgia 27) NIMESULIDE (TFF99)- Odctìalgy 28) NIMESULIDE (TFF122)- Gingivkis 29) NORAMIDOPIRINA (TTF115)- Ccphalea 30) NORAMIDOPIRINA (TFF98)- Ccphalea 31) NORAMIDOPIRINA (TPF34)- Luxatico 32) NORAMIDOPIRINA (TFP36)- Ccphalea 33) NORAMIDOPIRINA (TFF39)- Gonalgia 34) NORAMIDOPIRINA (TFF43)- Ccphalea 35) NORAMIDOPIRINA (TFF59)- Ccphalea 36) NORAMIDOPIRINA CTFF64)- Ccphalea 37) NORAMIDOPIRINA (TFF66> Headache 38) A C ACETILSALICILICO (TFF114> Pharyngitis 39) A C ACTTILSALOLICO (TPF33)- Back pain 40) A C ACETILSALICILICO (TFP61)- Ccphalea 41) A C ACETILSALICILICO (TFF83)- Back pam 42) PKOXICAM-CICLODESTRINA (TFF32)- Ccphalea 43) PROXICAM-aCLODESTRINA (TFF51> Neuralgia 44) SEAPROSB (TFF07> Tracheida

RESPONSE 45) PROPIFENAZONE-BUTALBrrAL-CAPFEINA (TFF123)- Ccphalea 46) PROPIFEWAZONE-Bin-AUn-AL^CAPPEINA OFFIOI)- Ccphalea 47) mOPIFENAZONE-PARACETAMOLO-CAPFEINA (TFF14)- Ccphalea 48) PROPIFENAZONE-PARACETAMOLO-CAFFEINA (TPF55)- Ccphalea 49) PROCLO RPERA20 NE-INDO METACINA-CAFFELNA CTFF31)- Ccphalea 50) PROCLO RPERAZONE-INDO METACINA-CAFFEINA (TFF65)- Ccphalea 51) FROCLORPERAZONE-INDOMETACLNA-CAFFEINA (TPF67)- Ccphalea 52) FEPRA20NE-PARACETAMO LO-NOREFED RINA-CLORFENAMINA (TPF57)- S inusiui 53) FEPRAZONE-PARACETAMOLO-NOREFEDRINA-CLORFENAM- (TPF42)- Fharyngiti. 54) BROMELINA- DESOSSIRIBONUCLEASI OTF05> Tendinina 55) BROMELINA- DESOSSIRIBONUCLEASI (TPP06> Pharyagkli 56) BROMELINA- DESOSSIRIBONUCLEASI (TFF73> Pharyngihs 57) BROM.- DESOSS.-NIMESULIDE-COTRIMOSS A2OL0 (TFP15)- Phaiyngiui 58) BROM.- DESOSS.•NIMESUUDB- AMOXICILLINA (TFP50> Pharyngitis 59) BROM.- DESOSS.-NIMESUUDE-CLARrrROMICINA (TFP74)- Pharyngitis 60) BROM.- DESOSS.-NIMESUUDE-CLARITROMiaNA (TFF82)- Pharyngitii 61) BROM.- DESOSS.-NAPROXENE-CLARITR.-AMOXICILLINA (TFF109)- Gingivitii 62) BROM.- DESOSS.-NTMESULIDE (TFFS7)- Pharyngitii 63) BROM.- DESOSS.-NIMESUUDE-SEAPROSE-ClARrrR. (TFF88)- Influenza 64) NIMESULIDE-SE APROSE (TFP81> Pharyngitis 65) PIROXICAM-ROCrVERINA (TFP13)- Kidney Colie 66) DEFIJV2>COPT-CBFALESSINA (TFF56)- Uveitis

1) TRIAMCINOLONE - Arthralgia 2) TENOXICAM - Arthralgia 3) TENOXICAM - Pain in post-hemiparesis 4) TENOXICAM - Cervical pain 5) TENOXICAM - Arthritis 6) TENOXICAM - Sciatica 7) NORAMIDOPIRINA - Cephalea 8) NORAMIDOPIRINA - Ccphalea

CASES WITH NO TERAPEUTIC 9) NIMESULIDE - Pharyngitii 10) NIMESULIDE - Rheumatoid Arthritis 11) NIMESULIDE - Fratture pain 12) INDOMETAONA - Ccphalea 13) NAPROXENE - Dysmenorrhea 14) NAPROXENE - Dysmenorrhei 15) NAPROXENE -Nevralgia 16) DICLOFENAC- Back pain

RESPONSE 17) KETOPROFENE - Sciatica 18) IBUPROFENE - Dysmenorrhea 19) DICLOFENAC-ROCrVERINA - Kidney colie 20) PROPIFENAZONE-ALLOBARBITALE - Dysmenorrhea 21) PIROXICAM-CICLODESTRTNA - Psoriasi! Arthritis 22) NIMESULIDE- PLROXICAM-CICLODESTRINA - Ccphalea 23) INDOMETACINA-PROCLORPERAZINA-CAFFEINA - Ccphalea

D I S C U S S I O N Although the exiguity of our sample does not allow us to operate a statistic evaluation, we stili wanted to check whether our 74% of positive cases were due to the subtype of the specific drug used. As for the negative cases, they do not seem to depend on the kind of drugs used. In our opinion the negative cases (26%) might depend on various factors, such as unsatisfactory amplification of the signal, wrong choice of the drug, mistakes in the patients' own administration of the drug and various other eventual environmental or chronological variables that might have disactivated the TFF action during the signal transfer and therefore the liquid vector itself.

S T A T E M E N T OF T H E O R Y On the basis of the results that we obtained in 5 years of experimentation in medicai clinic practice and laboratory (on isolated organs, on unicellulars and on animai and vegetable models) (3), we have come to the cohclusion that drugs release signals, which may be electromagnetic, provided with pharmacologic activity. Subjected to an amplifier, they produce effects on a subject that receives them directìy or by means of a liquid vector (5). We have therefore formulated our theory of Metamolecular Informed Signals (MIS) (Fig. 4). In our opinion, the amplifier records a concert of waves coming from the backgrounduoise, including the specific MIS. It amplifies ali the waves and it impregnates water with them; then the biologie receptors behave as if in presence of the drug (2) (Fig. 5).

METAMOLECULAR INFORMED SIGNALS (M.I.S.)

1 ) ALL SUBSTANCES CONTINUALLY AND SPONTANEUSLY

EMIT N O N MOLECULAR SIGNALS THAT ARE BOTH SPECIFIC

AND INFORMED. LE. ABLE TO REPRODUCE THE PRO-

PERTIES AND EFFECTS OF A SUBSTANCE EVEN IN ITS

ABSENCE.

2) THESE SIGNALS CAN BE INTERCEPTED, AMPLIFIED AND F I

TRANSM1TTED DIRECTLY TO A BIOLOGICA!. SYSTEM WHICH ''

WILL RECEIVED THEM, OR ELSE, THEY CAN BE RECORDED

IN A LIQUID VECTOR WHICH WILL MEMORIZE THEM.

3) THE ADMINISTRATION OF THIS VECTOR OR THE DIREC-

TLY APPLICATION OF THE SIGNALS TO A BIOLOGICAL

SYSTEM WILL INDUCE THE SPECIFIC EFFECT OF THE ORIGI­

NAI. SUBSTANCE, IN THIS CASE THE DRUG. P L A

HYPOTHESIS ON T H E PHENOMENON OF T H E

RECEPTIVE SIGNAL THROUGH T F F

BIOLOGICAL SYSTEM

TARGKTSYSTRM

ci». SIGNAL (MIS) -4 ci». SIGNAL (MIS)

RKACTION PKIM1NG

-4

i

SEVERAL METABOLIC PASSAGES

/ ^ _ J - . . M

CHEMICAL MOLECUL

THE TARGET SYSTEM RECEIVE ELECTROMAGNETIC TRIGGER';

SIGNALS AND RECOGNIZE THEM EVEN IF ARE FREE OR

MOLECULE BINDING.

Fig. 5

E X P E R I M E N T A L S U P P O R T

To obtain more direct and tangible proof of the TFF phenomenum, so to exclude as much as possible a placebo effect, we have been working for years on laboratory experiments on animai and vegetai models. We name two in particular: 1) Thyroxine action on tadpoles' metamorphosis 2) Herbicides action on the growth of vegetable sprouts We check all the biological experiments with Water TFF, that is, prepared leaving the entry empty in order to exclude the variable of a possible interference of electromagnetic signals coming from the apparatus (the only vàriable between Water TFF and Drug TFF is the presence of the drug itself). The same water (purified by P U R O L U X , Firma E R A , Germany) is used for ali T F F (Water or Drug), except for the Ladpoles' model (pond water).

A N I M A L M O D E L S

I N T R O D U C T I O N - Thyroxine plays an important steering role in the metamorphosis of amphibia. We used TFF of this hormone on Rana Temporaria and it has shown significative effects. M E T H O D S - For the experiments (in accordance with a protocol studied by Dr. P.CEndler, Graz) we chose only two-legged tadpoles which had just started to develop their hind legs. The tadpoles were monitored until they hed entered the four-legged stage (Fa). Furthermore, the animals were monitored until they hed entered the stage with reduced tail (Fb). Having reached this stage, the animals were transferred in a naturai biotope. Basins containing 18 animals each were used for a total of 108 animals. Three basins were used for treatment with, respectively, liquid Thyroxine (sodium pentahydrate, S IGMA 1 : IO"3) TFF and three with water TFF. 8 mi of Thyroxine TFF or 8 mi of control (water TFF) were added blindly to the corresponding basins (each basin contained 8 1 of water) foHowed by gentle stirring every 8 hours. The corresponding amount of liquid (8 mi) was always pipetted out of the water basins. Temperature was kept about 18°C. Indirect light was used. The tadpoles were fed with cooked greens (lettuce).The first experiment took place in Graz (P.C. Endler, W. Pongratz, Zoolog.U.Inst., Graz, Austria) in late Spring 1993. The sets of experiment were coded at the University of Graz and presented at the A A A S meeting "Science Innovation 93", Boston, USA (4). Reproductibility has been obtained in May/June 1994 with a multicentric Torino (184 aa) and Graz (540 aa) (8). R E S U L T S - In preliminary experiments (Graz 1993) Thyroxine TFF caused a dropping of Fa by 10% and of Fb by 30% (4,6). The difference referred to the sum of all the experiments (1993-1994, tot. 936 aa) is between 15 and 16% for both Fa and Fb, with a statistic significance of p<0.01 in chi-square test

V E G E T A B L E M O D E L S

I N T R O D U C T I O N - Glyphosate is a total herbicide for soil. Its application on Ervum lens sprouts damages the buds, stops the growth and induces the death ot the plant. M E T H O D S - 10 capsules containing 10 seeds of Ervum lens each have been used. 5 were treated with water TFF and 5 wi(h Glyphosate pure acid TFF (360 gr/1, COMPO). Each capsule was initially soaked with with 15 mi of solution.(Water TFF or Glyphosate TFF) and 3 mi were added every 12 hours, for 10 days. At every solution addition, the stern height, expressed in mm, of every plant was measured and the mathematical average of each group was considered. R E S U L T S - In all our experiments in accordance with this protocol, visible signs of sufference were observed in almost all the plants treated with Glyphosate TFF, with damaged apex and growth slowdown. The growth curves on the graph show Constant inhibition (form a minimum of 31% to a maximum of 63%) for all groups treated with herbicide TFF. The statistic significance is excellent (p<0.001) (Fig. 7). The experiment is reproducible and it attests the presence, in TFF drops, of a signal capable of inducing sufference and growth stop of the plants, as if a solution of the herbicide itself was used.

D I S C U S S I O N

According to our observations after the TFF administration on the above biologie models, we are in the position to assert that the inhibition observed in the animai model is caused by the toxic effect due to a too high concentration of Thyroxine; while in the vegetable model inhibition depends on the herbicede's own effect. As shown by a comparison between the results obtained with the biologie models and those observed in the clinic practice the in a sensible difference between the two experiences concerning the percentage of positive response. These data seem to confirm the hypothesis we previously illustrated, concerning the clinic casistic, according to which several variables, both known and unknown, interfere when it is impossible to work in conditions of laboratory standards and are the reason of the missing responses in the clinic practice.

C O N C L T J S I O N S

On the basis of the results we obtained, our conclusions can be synthesized as follows: 1) the MIS that we assumed, of stili unknown nature (it might be electromagnetic), and their coherence characteristic exist, 2) it is presently impossible to measure the MIS because of their extreme weakness, 3) the MIS can be used and transferred by means of TFF, 4) the action of TFF seems to depend on the concentration of the drug used, 5) it seems that there may be a model after which the drug doesn't act merely chemically, but it also behaves as a medium of an information of electromagnetic type capable, by itself, of provoking a response on the target system, 6) every celi would therefore be able to recognize both the MIS directly released by the drug and the MIS administered by us through TFF in the same way, 7) the MIS compose a sort of general file of all the information that serves the purpose of defining a substance, similar to the genetic code function carried on by cellular D N A in biologie Field.

R E F E R E N C E S

1) Citro M , TFF un'alchimia elettronica: basi teoriche e dati preliminari. Soc. It. Moraterapia (1990). E M P E D O C L E , a. X , n. 2/92. 2) Citro M , TFF von Pharmakon zur Frequenz. II Int. Symp. biocyb. Med Wurzburg (1991). VIVIBIOS. a. II, n. 3/92. 3) Cirro M , Biologische Experimente mit Hilfe des TFF. IV int. Symp. Biokyb. Med. BadHomburg (1993). 4) Citro M , Pongratz W , Endler PC, Transmission of hormone signals by electronic circuitry. A m . Ass. Adv. Sci. Meet.. Boston, 1993. 5) Citro M , Metamolecular Informed Signals theory and TFF. Wien. int. Akad. f. Ganzheitsmed., Wien, 1993. 6) Citro M , Smith C W , Scott-Morley A , Pongratz W, Endler PC, in Ultra High Dilution . Physiology and Physics. pp.209-214, Kluwer Acad. Pubi., Dordrecht, 1994 . 7) Citro M , Sacchi R, Vinattieri C , Metasegnali informati e TFF, M E D I C I N A N A T U R A L E a. IV n. 4, 1994. 8) Citro M , Endler PC, Pongratz W, Vinattieri C, Hormone effects by electronic transmission. F A S E B J. 1995 (in printing).