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- Roberto Federico Villa – Elena Arrigoni - Farmacologia Generale (Anno 1993) - Edizioni “La Goliardica Pavese”

- Roberto Federico Villa - Principi di Farmacologia Generale (Anno 1993, I Edizione; Anno 1996, II Edizione) - Edizioni “La Goliardica Pavese”

- Roberto Federico Villa – Antonella Gorini - Principi di Farmacologia Generale (Anno 2004, I Edizione; Anno 2007, II Edizione, Anno 2011, III Edizione) - Edizioni “La Goliardica Pavese”

- Roberto Federico Villa - Molecular Pharmacology (Monografia - Anno 2010, I Edizione) - Roberto Federico Villa – Antonella Gorini - Principi di Farmacologia Generale (Anno

2013, I Edizione, Anno 2015 II Edizione, Anno 2017 III Edizione)) - Edizioni “Medea”, Pavia

PPAARRTTEE II.. PPUUBBBBLLIICCAAZZIIOONNII SSPPEERRIIMMEENNTTAALLII EEDDIITTEE SSUU RRIIVVIISSTTEE SSCCIIEENNTTIIFFIICCHHEE

NNAAZZIIOONNAALLII EEDD IINNTTEERRNNAAZZIIOONNAALLII

1) Villa RF, Panceri P. Action of some drugs on performance time in mice. Il Farmaco Ed.

Pr., 28, 43-48 (1973). 2) Benzi G, Arrigoni E, Panceri P.Villa RF, D'Angelo L, Panzarasa R, Autelli M, Bertè, F.

Action of some antispasmodics on gastrointestinal muscle. Digestion, 11, 72-89 (1974).

3) Villa RF, Benzi G. Drugs and muscular pathways of pyruvate metabolism adapted to endurance training. Il Farmaco Ed. Pr., 30, 311-314 (1975).

4) Benzi G, Panceri P, De Bernardi M., Villa RF, Arcelli E., D'Angelo L., Arrigoni E, Bertè F. Mitochondrial enzymatic adaptation of skeletal muscle to endurance training. J. Appl. Physiol., 38, 565-569 (1975).

5) Villa RF. Effect of hypoxia on the cerebral energy state. Il Farmaco Ed. Pr., 30, 561-569 (1975).

6) Benzi G, Villa RF. Adenyl cyclase system and cerebral energy state. J. Neurol. Neurosurg. Psych., 39, 77-83 (1976).

7) Benzi G, Villa RF, Pastoris O, Arrigoni E, Strada P, Ogliari M., Montani A. Drugs and brain mitochondrial enzymatic activities during post-natal development in rat. Il Farmaco Ed. Pr., 31, 412-417 (1976).

8) Benzi G, Arrigoni E, Pastoris O, Villa RF. Muscle metabolism investigated at rest and during exercise and/or pharmacological treatment by vasodilators. lI Farmaco Ed. Pr., 31, 3-20 (1976).

9) Villa RF, Strada P, Barbieri G. A comparative study on some mitochondrial enzymes from rat brain. Il Farmaco Ed. Pr., 32, 192-196 (1977).

10) Benzi G, Villa RF, Montani A., Pastoris O, Arcelli E, Strada P, Arrigoni E. Influence of training and pharmacological treatment on muscular enzymatic activities. J. Pharm. Sci., 66, 1278-1281 (1977).

11) Benzi G, Arrigoni E, Strada P, Pastoris O, Villa RF, Agnoli A. Metabolism and cerebral energy state: effect of acute hyperammonemia in beagle dog. Biochem. Pharmacol., 26, 2397-2404 (1977).

12) Benzi G, Arrigoni E, Villa RF, Agnoli A. Effect of acute hyperammoniemia on metabolism and cerebral energy state. Monogr. Gesamtgeb. Psychiatr. Psychiatry Ser., 18, 79-99 (1978).

13) Villa RF, Strada P, Dagani F, Benzi G. Magnification of some enzymatic activities of brain cortex subfractions. Biochem. Pharmacol., 27, 2278-2280 (1978).

14) Villa RF, Strada P, Marzatico F, Dagani F, Effect of (-)eburnamonine, papaverine and UDP-glucose on cerebral energy state during and after experimental hypoxia and ischemia in beagle dog. Eur. Neurol., 17, 97-112 (1978).

15) Benzi G, Villa RF, Arrigoni E, Agnoli A. Cerebral energy status and the acute hyperammoniemia syndrome: interference of S-adenosyl-L-methionine and adenosine. Minerva Med., 69, 661-670 (1978).

16) Benzi G, Arrigoni E, Dagani F, Pastoris O, Villa RF, Agnoli A. Cerebral energy state during or after hypoxia and complete or incomplete ischemia. J. Appl. Physiol., 45, 312-319 (1978).

17) Benzi G, Arrigoni E, Dagani F, Marzatico F, Manzini A., Pastoris O, Villa RF. Drug action on cerebral energy state during and after various hypoxic conditions. Arch. Int. Pharmacodyn. Therap., 236, 234-251 (1978).

18) Benzi G, Arrigoni E, Strada P, Villa RF. Enzymatic activities in the senescent brain

and interference with S-adenosyl-L-methionine. Exp. Geront., 14, 183-187 (1979). 19) Benzi G, Arrigoni E, Pastoris O, Villa RF, Dagani F, Marzatico F, Agnoli A. Effect of

some drugs on cerebral energy state during and after hypoxia and complete or incomplete ischemia. Biochem. Pharmacol., 28, 435-439 (1979).

20) Arrigoni E, Benzi G, Dagani F, Falconi G., Mandelli V., Moretti A., Scelsi R., Villa RF. Zerebrale Enzymatische Activitatin Verbindung mit Energieumwandlungsprozessen. Arzneim. Forsch. (Drug Res.), 29, 1231-1237 (1979).

21) Benzi G, Arrigoni E, Dagani F, Carini L., Curti D, Villa RF. S-adenosyl-L-methionine, related compounds and cerebral enzymatic activities during chronic hyperammonemia in rats. Toxicol. Appl. Pharmacol., 48, 11-18 (1979).

22) Benzi G, Arrigoni E, Marzatico F, Villa RF- Influence of some biological pyrimidines on the succinate cycle during and after cerebral ischemia. Biochem. Pharmacol., 28, 2545-2550 (1979).

23) Benzi G, Arrigoni E, Dagani F, Marzatico F, Curti D, Manzini A., Villa RF. Effect of chronic treatment with some drugs on the enzymatic activities of the rat brain. Biochem. Pharmacol, 28, 2703-2708 (1979).

24) Benzi G, Agnoli A., Dagani F, Ruggieri S., Villa RF. Effect of phenobarbital on cerebral energy state and metabolism. Stroke, 10, 733-736 (1979).

25) Benzi G, Arrigoni E, Dagani F, Marzatico F, Curti D, Raimondo S., Dossena M., Polgatti M., Villa RF. Age dependent modifications of drug interference on the enzymatic activities of the rat brain. Exp. Geront., 15, 593-603 (1980).

26) Benzi G, Arrigoni E, Scelsi R., Marzatico F, Gorini A., Villa RF. Acetylcholinesterase sensitivity to chronic administration of diphenylhydantoin and effects on cerebral enzymatic activities related to energy metabolism. Neurochem. Res., 5, 905-911 (1980).

27) Benzi G, Arrigoni E, Marzatico F, Pastoris O, Polgatti M., Villa RF. Effect of alphaxalone-alphadolone on some enzymatic activities from rat brain. Il Farmaco Ed. Pr., 35, 771-778 (1980).

28) Benzi G, Arrigoni E, Pastoris O, Raimondo S., Dossena M, Fulle D., Tuminello MC, Villa RF. Drug interference on some biochemical parameters of rat cerebral cortex during post-ischemic recovery. Arch. Int. Pharmacodyn. Therap., 247, 198-215 (1980).

29) Villa RF. Brain enzymes and ischemia. Eur. Neurol., 20, 245-252 (1981). 30) Benzi G, Arrigoni E, Pastoris O, Raimondo S, FULLE, D., Curti D, Villa RF. Metabolic

changes induced by acute hypoxia on the synaptosomes from dog brain. Eur. Neurol., 20, 235-244 (1981).

31) Villa RF, Raimondo S, Curti D. Cerebral enzymatic activities during chronic hyperammonemia and treatment with S-adenosyl-L-methionine in rat. Il Farmaco Ed. Pr., 36, 251-259 (1981).

32) Benzi G, Arrigoni E, Pastoris O, Raimondo S, Fulle D., Villa RF. Phenobarbital interference on cerebral metabolism related to energy transduction. Il Farmaco Ed. Pr., 36, 804-810 (1981).

33) Benzi G, Arrigoni E, Pastoris O, Marzatico F, Curti D, Piacenza G., Villa RF. Effect of vincamine on some enzymatic activities from various areas of the beagle dog cerebral cortex. Il Farmaco Ed. Pr., 36, 811-816 (1981).

34) Villa RF, Benzi G, Curti D. The effect of ischemia and pharmacological treatment evaluated on synaptosomes and purified mitochondria from rat cerebral cortex. Biochem. Pharmacol., 30, 2399-2408 (1981).

35) Curti D, Marzatico F, Dagani F, Villa RF, Benzi G. Effect of ischemia and pharmacological treatment on subcellular fractions from neonatal rat brain. Il Farmaco Ed. Pr., 37, 275-282 (1982).

36) Villa RF, Curti D, Polgatti M, Benzi G. Synaptosomes and mitochondria from rat

brain cerebral cortex. In vivo interference on some enzymatic activities by SAMe and CDP-choline. J. Neurosc. Res., 7, 341-347 (1982).

37) Benzi G, Arrigoni E, Agnoli A., Raimondo S, Fulle D, Pastoris O, Curti D, Villa RF. Influence of age upon the cerebral metabolic changes induced by acute hypoxia on the synaptosomes from dog brain. Exp. Geront., 17, 19-31 (1982).

38) Benzi G, Arrigoni E, Pastoris O, Villa RF, Dossena M, Agnoli A, Giuffrida AM. Drug action on the metabolic changes induced by acute hypoxia on synaptosomes from the cerebral cortex. J. Cereb. Blood Flow Metabol., 2, 229-239 (1982).

39) Dagani F, Gorini A, Polgatti M, Villa RF, Benzi G. Rat cortex synaptic and non-synaptic mitochondria: enzymatic characterization and pharmacological effects of naftidrofuryl. J. Neurosci. Res., 10, 135-140 (1983).

40) Villa RF, Marzatico F, Benzi G. Changes induced by ischemia on some cerebral enzymatic activities related to energy transduction and amino acids metabolism. Neurochem. Res., 8, 269-290 (1983).

41) Gorini A, Villa RF. Action of dihydroergocristine on enzyme activities related to energy transduction. Il Farmaco Ed. Pr., 38, 191-199 (1983).

42) Dagani F, Gorini A, Polgatti M, Villa RF, Benzi G. Synaptic and non-synaptic mitochondria from rat cerebral cortex. Characterization and effect of pharmacological treatment on some enzyme activities related to energy transduction. Il Farmaco Ed. Pr., 38, 584-594 (1983).

43) Villa RF, Gorini A. Effect of ischemia and pharmacological treatment on enzyme activities of cortical mitochondria and synaptosomes. Int. J. Clin. Pharm. Res., 4, 263-275 (1984).

44) Benzi G, Pastoris O, Villa RF, Giuffrida, AM. Effect of aging on cerebral cortex energy metabolism in hypoglycemia and posthypoglicemic recovery. Neurobiol. Aging, 5, 205-212 (1984).

45) Benzi G, Villa RF, Dossena M, Vercesi L, Gorini A, Pastoris O. Cerebral and cerebellar metabolic changes induced by drugs during the recovery period after profound hypoglycemia. Il Farmaco Ed. Pr., 39, 44-56 (1984).

46) Benzi G, Villa RF, Dossena M, Vercesi L, Gorini A, Pastoris O. Cerebral endogenous substrate utilization during the recovery period after profound hypoglycemia. J. Neurosci. Res., 11, 437-450 (1984).

47) Arrigoni E, Benzi G, Curti D, Dagani F, Gallico S, Gorini A, Mandelli A, Marzatico F, Moretti A, Villa RF. Effect of hypoxia and pharmacological treatment on some enzyme activities in dog brain areas. Arch. Int. Pharmacodyn. Therap., 269, 111-140 (1984).

48) Benzi G, Villa RF, Dossena M, Vercesi L, Gorini A, Taglietti M, Pastoris O. Recovery period after profound hypoglycemia. Influence of some metabolic modulators on the cerebral endogenous substrate utilization. Il Farmaco Ed. Pr., 39, 430-449 (1984).

49) Benzi G, Villa RF, Dossena M, Vercesi L, Gorini A, Pastoris O. Role of drugs in recovery of metabolic function of rat brain following severe hypoglycemia. Neurochem. Res., 9, 979-992 (1984).

50) Benzi G, Pastoris O, Villa RF, Giuffrida, AM. Influence of aging and exogenous substances on cerebral energy metabolism in posthypoglycemic recovery. Biochem. Pharmacol., 34, 1477-1483 (1985).

51) Villa RF, Gorini A, Zanada F, Benzi G. Action of L-acetylcarnitine on different cerebral mitochondrial populations from hippocampus. Arch. Int. Pharmacodyn. Therap., 279, 195-211 (1986).

52) Villa RF, Pastoris O. Influence du veillissement sur le métabolisme énérgetique cérébral pendant la récupération post-hypoglycemique chez le rat - application pharmacologique. J. Pharmacol., 17, 623-636 (1986).

53) Benzi G, Pastoris O, Vercesi L, Gorini A, Viganotti C, Villa RF. Energetic state of aged

brain during hypoxia. Gereontology, 33, 207-212 (1987). 54) Villa RF, Pastoris O. Effect du veillissement et de divers agents pharmacologiques sur

le métabolisme énérgetique cérébral au cours de la récupération post-hypoglycemique chez le rat. La Press Méd., 16, 1128-1134 (1987).

55) Benzi G, Pastoris O, Tentoni S, Villa RF. Modifications in cerebral lipid metabolism by severe glucose deprivation during aging. Neurobiol. Aging, 8, 457-463 (1987).

56) Benzi G, Pastoris O, Villa RF. Changes induced by aging and drug treatment on cerebral enzymatic antioxidant system. Neurochem. Res., 13, 467-478 (1988). 57) Benzi G, Pastoris O, Marzatico F, Villa RF. Influence of aging and drug treatment on the cerebral glutathione system. Neurobiol. Aging, 9, 371-375 (1988).

58) Turpeenoja L, Villa RF, Magrì G, Giuffrida-Stella AM. Changes of mitochondrial membrane proteins in rat cerebellum during ageing. Neurochem. Res., 13, 859-865 (1988).

59) Villa RF, Turpeenoja L, Benzi G, Giuffrida-Stella AM. Action of L-acetylcarnitine on age-dependent modifications of mitochondrial membrane proteins from rat cerebellum. Neurochem. Res., 13, 909-916 (1988).

60) Gorini A, Arnaboldi R, Ghigini B, Villa RF. Brain cytochrome oxidase activity of synaptic and non-synaptic mitochondria during aging. Basic Appl. Histochem., 33,139-145 (1989).

61) Benzi G, Marzatico F, Pastoris O, Villa RF. Relationships between aging, drug treatment and the cerebral enzymatic antioxidant system. Exp. Gerontol., 24, 137-148 (1989).

62) Villa RF, Arnaboldi R, Gorini A, Geroldi D. Action of piracetam and clonidine on different mitochondrial populations from hippocampus. Il Farmaco Ed. Sc., 44, 215-226 (1989).

63) Vanella A, Villa RF, Gorini A, Campisi A, Giuffrida-Stella AM. Superoxide dismutase and cytochrome oxidase activities in light and heavy synaptic mitochondria from rat cerebral cortex during aging. J. Neurosc. Res., 22, 351-355 (1989).

64) Benzi G, Pastoris O, Marzatico F, Villa RF. Age related effect induced by oxidative stress on the cerebral glutathione system. Neurochem. Res., 14, 573-581 (1989).

65) Benzi G, Pastoris O, Marzatico F, Villa RF. Cerebral enzyme antioxidant system. Influence of aging and phosphatidylcholine. J. Cereb. Blood Flow Metabol., 9, 373-380 (1989).

66) Villa RF, Gorini A, Lo Faro A, Dell’Orbo C. A critique on the preparation and enzymatic characterization of synaptic and non-synaptic mitochondria from hippocampus. Cell. Mol. Neurobiol., 9, 247-262 (1989).

67) Condorelli DF, Avola R, Ragusa N, Reale S, Renis M, Villa RF, Giuffrida-Stella AM. Age-dependent changes of nucleic acid labeling in different rat brain regions. Neurochem. Res., 14, 701-706 (1989)

68) Villa RF, Gorini A, Geroldi D, Lo Faro A, Dell’Orbo C. Enzyme activities in perikaryal and synaptic mitochondrial fractions from rat hippocampus during development. Mech. Aging Develop., 49, 211-225 (1989).

69) Benzi G, Marzatico F, Pastoris O, Villa RF. Influence of oxidative stress on the age-linked alterations of the cerebral glutathione system. J. Neurosci. Res., 26, 120-128 (1990).

70) Benzi G, Pastoris O, Dossena M, Marzatico F, Villa RF, Dagani F. Factors involved in the age-related alteration in the efficiency of the brain bioenergetics. Mech. Aging Develop., 56, 155-168 (1990).

71) Villa RF, Ghigini B, Arnaboldi R, Geroldi D.Gorini A. Factors involved in drug interference on enzyme activities of three mitochondrial populations from rat hippocampus. Eur. J. Basic Appl. Histochem., 35, 409-421 (1991)

72) Battino M, Bertoli E, Formiggini G, Sassi S, Gorini A, Villa RF, Lenaz G. Structural and functional aspects of the respiratory chain of synaptic and non-synaptic mitochondria derived from selected brain regions. J. Bioenerg. Biomembr., 23, 345-363 (1991).

73) Benzi G, Pastoris O, Gorini A, Marzatico F, Villa RF, Curti D. Influence of aging on the acute depletion of reduced glutathione induced by electrophilic agents. Neurobiol. Aging, 12, 227-231 (1991)

74) Villa RF, Turpeenoja L, Magrì G, Gorini A, Ragusa N, Giuffrida-Stella AM. Effect of hypoxia on mitochondrial protein composition of cerebral cortex during aging. Neurochem. Res., 16, 821-826 (1991).

75) Villa RF, Turpeenoja L, Magrì G, Gorini A, Ragusa N, Giuffrida-Stella AM. Effect of hypoxia on protein composition of synaptic plasma membranes from cerebral cortex during aging. Neurochem. Res., 16, 827-832 (1991)

76) Villa RF, Gorini A. Action of L-acetylcarnitine on different cerebral mitochondrial populations from hippocampus and striatum during aging. Neurochem. Res., 16, 1125-1132 (1991)

77) Benzi G, Curti D, Pastoris O, Marzatico F, Villa RF, Dagani F. Sequential damage in mitochondrial complexes by peroxidative stress. Neurochem. Res., 16, 1295-1302 (1991)

78) Villa RF, Gorini A. Enzyme mitochondrial systems during aging: pharmacological implications. Life Sci.Adv., 10, 49-59 (1991)

79) Battino M, Ferri E, Rodriguez Huertas JF, Pierluigi F, Genova ML, Marchetti M, Gorini A, Villa RF, Lenaz G. Natural distribution and occurrence of Coenzyme Q homologues. Membr. Biochem, 9, 179-190 (1991)

80) Benzi G, Pastoris O, Marzatico F, Villa RF, Dagani F, Curti D. The mitochondrial electron transfer alteration as a factor involved in the brain aging. Neurobiol. Aging, 13, 361-368 (1992).

81) Ragusa N, Villa RF, Magrì G, Ingrao F, Gorini A, Turpeenoja L, Giuffrida-Stella AM. Modifications of synaptosomal plasma membrane protein composition in various brain regions during aging. Int. J. Dev. Neuroscience, 10, 265-272 (1992)

82) Villa RF, Arnaboldi R, Ghigini B, Gorini A. Mitochondrial factors involved in Parkinson’s disease by MPTP toxicity in Macaca fascicularis and drug effect. Neurochem. Res., 17, 1147-1154 (1992)

83) Villa RF, Ingrao F, Magrì G, Gorini A, Reale S, Costa A, Ragusa N, Avola R, Giuffrida-Stella AM. Effect of CDP-Choline treatment on mitochondrial and synaptosomal protein composition in different brain regions during aging. Int. J. Dev. Neuroscience, 11, 83-93 (1993).

84) Benzi G, Gorini A, Ghigini B, Arnaboldi R, Villa RF. Synaptosomal non-mitochondrial ATPase activities and drug treatment. Neurochem. Res., 18, 719-726 (1993).

85) Benzi G, Gorini A, Arnaboldi R, Ghigini B, Villa RF. Effect of intermittent mild hypoxia and drug treatment on synaptosomal non-mitochondrial ATPase activities. J. Neurosci. Res., 34, 654-663 (1993)

86) Benzi G, Gorini A, Arnaboldi R, Ghigini B, Villa RF. Age-related alterations by chronic intermittent hypoxia on cerebral synaptosomal ATPase activities. J. Neural Transm., 44, 159-171 (1994)

87) Villa RF, Arnaboldi R, Ghigini B, Gorini A. Parkinson-like disease by 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) toxicity in Macaca fascicularis: synaptosomal metabolism and action of dihydroergocriptine. Neurochem. Res., 19, 229-236 (1994)

88) Benzi G, Gorini A, Ghigini B, Arnaboldi R, Villa RF. Modifications by hypoxia and drug treatment of cerebral ATPase plasticity. Neurochem. Res., 19, 517-524 (1994)

89) Benzi G, Gorini A, Arnaboldi R, Ghigini B, Villa RF. Synaptosomal non-mitochondrial ATPase activities: age-related alterations by chronic normobaric intermittent hypoxia. Neurochem. Int., 25, 61-67 (1994).

90) Benzi G, Gorini A, Arnaboldi R, Ghigini B, Villa RF. Age-related changes by hypoxia and TRH analogue on synaptic ATPase activities. Neurobiol. Aging, 15, 409-417 (1994).

91) Pastoris O, Dossena M, Arnaboldi R, Gorini A, Villa RF. Age-related alterations of

skeletal muscle metabolism by intermittent hypoxia and TRH-analogue treatment. Pharmac. Res., 30, 171-185 (1994).

92) Castelluccio C, Baracca A, Fato R, Pallotti F, Maranesi M, Barzanti V, Gorini A, Villa RF, Parenti Castelli G, Marchetti M, Lenaz G. Mitochondrial activities of rat heart during ageing. Mech. Ageing Develop., 76, 73-88 (1994).

93) Pastoris O, Dossena M, Foppa P, Arnaboldi R, Gorini A, Villa RF, Benzi G. Modifications by chronic intermittent hypoxia and drug treatment on skeletal muscle metabolism. Neurochem. Res, 20, 143-150 (1995).

94) Battino M, Gorini A, Villa RF, Genova ML, Bovina C, Sassi L, Littarru GP, Lenaz G. Coenzyme Q content in synaptic and non-synaptic mitochondria from different brain regions in the ageing rat. Mech. Ageing Develop., 78, 173-187 (1995).

95) Nicoletti VG, Tendi EA, Lalicata C, Reale S, Costa A, Villa RF, Guerrieri F, Ragusa N, Giuffrida-Stella AM. Changes of mitochondrial cytochrome c oxidase and F0F1 ATP synthase subunits in rat cerebral cortex during aging. Neurochem. Res., 20, 1465-1470 (1995).

96) Benzi G, Gorini A, Ghigini B, Moretti A, Dagani F, Villa RF. Is the Mg++-ATP-dependent proton pumping activity of the synaptic vesicles a factor involved in the cerebral hypoxia? Neurochem. Res., 21, 7-18 (1996)

97) Nicoletti VG, Tendi EA, Lalicata C, Reale S, Villa RF, Ragusa N, Giuffrida-Stella AM. Age-related changes of mitochondrial cytochrome c oxidase and F0F1 ATP synthase subunits contents in rat cerebral cortex. Arch. Gerontol. Geriatr., 22, 509-513 (1996).

98) Gorini A, Ghigini B, Villa RF. Acetylcholinesterase activity of synaptic plasma membranes during ageing and effect of L-acetylcarnitine. Dementia, 7, 147-154 (1996)

99) Battino M, Littarru GP, Gorini A, Villa RF. Coenzyme Q, peroxidation and cytochrome oxidase features after Parkinson’s-like disease by MPTP toxicity in intra-synaptic and non-synaptic mitochondria from Macaca fascicularis cerebral cortex and hippocampus: action of diidroergocriptine. Neurochem. Res., 21, 1505-1514 (1996)

100) Battino M, Svegliati Baroni S, Littarru GP, Bompadre S, Leone L, Gorini A, Villa RF. Coenzyme Q homologs and Vitamin E in synaptic and non-synaptic occipital cortex mitochondria in the ageing rats. Mol. Aspects Med., 18, 279-282 (1997)

101) Villa RF, Gorini A. Pharmacology of lazaroids and brain energy metabolism: a review. Pharmacological Review, 49, 99-136 (1997)

102) Genova ML, Bovina C, Marchetti M, Pallotti F, Tietz C, Biagini G, Pugnaloni A, Viticchi C, Gorini A, Villa RF, Lenaz G. Decrease of rotenone inhibition is a sensitive parameter of complex I damage in brain non-synaptic mitochondria of aged rats. FEBS Lett., 410, 467-469 (1997)

103) Nicoletti VG, Tendi EA, Console A, Privitera A, Villa RF, Ragusa N, Giuffrida-Stella AM. Regulation of cytochrome c oxidase and Fo-F1-ATPase subunits expression in rat brain during aging. Neurochem. Res., 23, 55-61 (1998)

104) Gorini A, D’Angelo A, Villa RF. Action of L-Acetylcarnitine on different cerebral mitochondrial populations from cerebral cortex . Neurochem. Res., 23, 1485-1491 (1998)

105) Gorini A, D’Angelo A, Villa RF. Energy metabolism of synaptosomal subpopulations from different neuronal systems of rat hippocampus: effect of L-acetylcarnitine administration in vivo. Neurochem. Res., 24, 617-624 (1999).

106) Villa RF, D’Angelo A, Gorini A. ATPases of synaptic plasma membranes and vesicles from rat cerebral cortex during ageing and hypoxia. Ann. N. Y. Acad. Sci., 893, 417-420 (1999).

107) Gorini A, Rancati A, D’Angelo A, Devecchi E, Villa RF. Effect of in vivo administration of naloxone on ATP-ases's enzyme systems of synaptic plasma membranes from rat cerebral cortex. Neurochem. Res., 25, 867-873 (2000).

108) Battino M, Quiles JL, Huergtas JR, Mataix JF, Gorini A, Villa RF. Cerebral cortex

synaptic heavy mitochondria may represent the oldest synaptic mitochondrial population: biochemical heterogeneity and effects of L-acetylcarnitine. J. Bioenerg. Biomembr., 32, 163-173 (2000)

109) Battino M, Bompadre S, Leone L, Villa RF, Gorini A. Coenzyme Q9 and Q10, Vitamin E and peroxidation in rat synaptic and non-synaptic occipital cerebral cortex mitochondria during ageing. Biol Chem., 382, 925-931 (2001)

110) Gorini A, Villa RF. Effect of in vivo treatment of clonidine on ATP-ases's enzyme systems of synaptic plasma membranes from rat cerebral cortex. Neurochem. Res., 26, 819-825 (2001)

111) Gorini A, Canosi U, Devecchi E, Geroldi D.Villa RF. ATP-ases enzyme activities during ageing in different types of somatic and synaptic plasma membranes from rat frontal cerebral cortex. Progr. Neuro-Psychopharmacol. & Biol. Psychiatry., 26, 81-90 (2002).

112) Villa RF, Gorini A, Hoyer S. ATP-ases of synaptic plasma membranes from hippocampus after ischemia and recovery during ageing. Neurochem. Res. 27, 861-870 (2002).

113) Battino M, Ferreiro MS, Littarru GP, Quiles JL, Ramirez-Tortosa MC, Huertas JR, Mataix JF, Villa RF, Gorini A. Structural damages induced by peroxidation could account for functional impairment of heavy synaptic mitochondria. Free Rad. Res., 36, 479-484 (2002).

114) Moretti A, Gorini A, Villa RF. Affective disorders, antidepressant drugs and brain metabolism. Mol. Psychiatr., 8, 773-785 (2003).

115) Battino M, Bompadre S, Leone L, Devecchi E, Degiuli A, D’Agostino F, Cambiè G, D’Agostino M, Faggi L, Colturani G, Gorini A, Villa RF. Coenzyme Q, Vitamin E and Apo-E alleles in Alzheimer Disease. Biofactors, 18, 277-281 (2003).

116) Villa RF, Gorini A, Hoyer S. Differentiated effect of ageing on the enzymes of Krebs’ cycle, electron transfer complexes, and glutamate metabolism of non-synaptic and intra-synaptic mitochondria from cerebral cortex.J .Neuronal Transm, 113, 1659-1670 (2006).

117) Villa RF, Gorini A, Hoyer S. Effect of ageing and ischemia on enzymatic activities linked to Krebs’ cycle, electron transfer chain, glutamate and aminoacids metabolism of free and intrasynaptic mitochondria of cerebral cortex. Neurochem. Res. 34, 2102-2116 (2009).

118) Moretti A, Gorini A, Villa RF. Pharmacology and prevention of vascular dementia. CNS & Neurological Disorders – Drug Targets. 10, 370-390 (2011).

119) Villa RF, Ferrari F, Gorini A. Effect of in vivo L-acetylcarnitine administration on ATP-ases enzyme systems of synaptic plasma membranes from rat cerebral cortex. Neurochem. Res. 36, 1372-1382 (2011).

120) Villa RF, Ferrari F, Gorini A. Functional proteomics of ATP-ases enzyme systems of rat striatum during aging. Neural. Reg. Res. 7, 6-12 (2012).

121) Villa RF, Ferrari F, Gorini A. Energy metabolism of rat cerebral cortex, hypothalamus and hypophysis during ageing. Neuroscience. 227, 55-66 (2012).

122) Villa RF, Ferrari F, Gorini A. Effect of CDP-Choline on age-dependent modifications of energy- and glutamate-linked enzyme activities in synaptic and non-synaptic mitochondria from rat cerebral cortex. Neurochem. Int., 61, 1424-1432 (2012).

123) Villa RF, Ferrari F, Gorini A. ATP-ases of synaptic plasma membranes in striatum: enzymatic systems for synapses functionality by in vivo administration of L-acetylcarnitine in relation to Parkinson’s disease. Neuroscience, 248, 414-426 (2013).

124) Villa RF, Ferrari F, Gorini A, Hoyer, S. Energy metabolism of cerebral during ageing, ischemia and post-ischemic recovery assessed by functional proteomics of enzymes. Neurochem. Int., 63: 765-781 (2013)

125) Villa RF, Ferrari F, Gorini A. Functional proteomics related to energy metabolism of synaptosomes from different neuronal systems of rat hippocampus during aging. J. Proteome Res., 12: 3422-3435 (2013)

126) Moretti A., Ferrari, F.,Villa RF. Neuroprotection for ischaemic stroke: current status and challenges. Pharmacology and Therapeutics, 146, 23-34 (2015); on-line 2014.

127) Ferrari F, Gorini A., Villa RF. Energy metabolism of synaptosomes from different neuronal systems of rat cerebellum during aging: a functional proteomic characterization. Neurochem. Res., 40, 172-185 (2015); on-line 2014.

128) Villa RF, Ferrari F, Gorini A. Functional proteomics of synaptic plasma membrane ATP-ases of rat hippocampus: effect of L-Acetylcarnitine in vivo administration and relationships with Dementia and Depression pathophysiology. Eur. J. Neuropharm., 756, 67-74 (2015).

129) Moretti, A., Ferrari F, Villa RF. Pharmacological therapy of acute ischaemic stroke: achievements and problems. Pharmacology and Therapeutics, 153, 79-89 (2015).

130) Villa, R.F., Ferrari, F. Functional Proteomics as Marker for neurological and psychiatric disorders: the first application to dementia for an immediate future. J. Neurol. Neurosci. 7, 1-4 (2016).

131) Ferrari, F., Devecchi, E., Pero, G., Gorini, A., Villa, R.F. Bioenergetic characterization of lymphocytes from stroke depression. Cerebrovascular Disease, 41(1), S44 (2016). 3.754

132) Villa RF, Ferrari F, Gorini A, Brunello, N, Tascedda, F. Effect of Desipramine and Fluoxetine on energy metanolism of cerebral mitochondria. Neuroscience, 330, 326-334 (2016).

133) Ferrari, F., Villa, R.F. (2016). The neurobiology of depression: an integrated overview from the biological theories to clinical evidence. Mol. Neurobiol., 54, 4847-4865 (2017).

134) Villa R.F., Ferrari F., Moretti, A. (2016). Effects of neuroprotectants before and after stroke: statins and anti-hypertensives. In: Lapchak, P., Zhang, J. (Eds.), Neuroprotective Therapy for Stroke and Ischemic Disease. Springer Series in Translational Stroke Research, Chapter 14, 329-399 (2017).

135) Villa, R.F., Ferrari, F., Bagini, L., Gorini, A., Brunello, N., Tascedda, F. Mitochondrial energy metabolism of rat hippocampus after treatment with antidepressants Desipramine and Fluoxetine Neuropharmacology, 121, 30-38 (2017).

136) Ferrari, F., Bascì, J., Bagini, L., Viscardi, P., Pero, G., Moretti, A., Villa, R.F.

Prevention of Acute and recurrent stroke by anti-hypertensives: interaction with

thrombolysis. Cerebrovascular Disease. 43(1): S164 (2017)

137) Villa RF, Ferrari F, Gorini A, Hoyer, S. Functional proteomics (glutamate) of brain

energy metabolism: activities of non-synaptic and intra-synaptic mitochondria

from cerebral cortex after ischemia and post-ischemic recirculation during aging.

J. Neurochem., 146, 416-428 (2018).

138) Villa, R.F., Ferrari, F., Moretti A.. Post stroke depression: mechanisms and

pharmacological treatment. Pharmacology and Therapeutics, 184, 131-144 (2018)

139) Ferrari, F., Bagini, L., Pero, G., Moretti, A., Villa, R.F. Physiopathological

mechanisms and pharmacological treatment of post-stroke depression.

Cerebrovascular Disease. 45(1), (2018)

140) Ferrari, F., Viscardi, P., Gorini, A., Villa, R.F. Physiopathological mechanisms and

pharmacological treatment of post-stroke depression. Neurosci. Lett..694: 74-79

(2019)

PPAARRTTEE IIII.. PPUUBBBBLLIICCAAZZIIOONNII SSPPEERRIIMMEENNTTAALLII EEDDIITTEE SSUU AATTTTII DDII CCOONNGGRREESSSSII EE SSUU

RRIIVVIISSTTEE SSPPEECCIIAALLIIZZZZAATTEE AA CCAARRAATTTTEERREE DDIIVVUULLGGAATTIIVVOO OO SSUU LLIIBBRRII

1) Benzi G, Arrigoni E, Pastoris O, Villa RF. Effect of pharmacological treatment by

vasodilators on muscle metabolism. Atti I° Congresso della Società di Microangiologia e Microcircolazione, Cagliari, 1975.

2) Arrigoni E, Fanfani A, Montani A, Scelsi R, Villa RF. Effetti del veleno di Phoneyusa lesserti (Araneae): rilievi biochimici, istologici ed enzimo istochimici a livello della muscolatura striata di ratto. Pubbl. Ist. Entom. Argr. Univ. Pavia & C.N.R., 4, 3-11 (1976).

3) Villa RF, Arrigoni E, Pastoris O, Benzi G. Studio sulla eventuale interferenza della caffeina e della papaverina su alcune vie cvicarie della metabolizzazione del piruvato attivate dall’allenamento di durata. Medicina dello Sport, 29, 21-26 (1976)

4) Villa RF, Arrigoni E, Arcelli, E., Benzi G. Allenamento ed attività enzimatiche mitocondriali del muscolo scheletrico di ratto. Medicina dello Sport, 29, 212-214 (1976)

5) Benzi G, Arrigoni E, Villa RF, Agnoli A. Effect of acute hyperammonemia on metabolism and cerebral energy state. In "Transmethylation and the Central Nervous System" (V.M. Andreoli, A. Agnoli and C. Fazio, eds.), pp. 79-99, Springer-Verlag, Berlin (1978).

6) Benzi G, Arrigoni E, Villa RF, Agnoli A. Influence of phenobarbital on cerebral metabolic pathways related to energy transduction . In "Cerebral Vascular Disease" (J.S. Meyer, H. Lechner and R. Reivich, eds.), pp. 351-354, Excerpta Medica, Amsterdam-Oxford (1978).

7) Benzi G, Arrigoni E, Dagani F, Marzatico F, Curti D, Polgatti M, Villa RF. Role of cerebral enzymatic activities in the relationships between energy metabolism and amino acid acting as neurotrasmitters. In "Cerebral Circulation" (A. Bes and G.

Géraud, eds.), pp. 241-246, Excerpta Medica, Amsterdam-Oxford (1979) 8) Benzi G, Villa RF, Arrigoni E, Actividades enzimaticas cerebrales en relaciòn con la

transferencia de energia en el cerebro de rata adulta: efecto del tratamiento con algunos fàrmacos. In "Transtornos Cerebrovasculares", pp. 106-125, Excerpta Medica, Amsterdam-Oxford (1979).

9) Agnoli A, Palesse N, Bocola V, Ruggieri S, Leonardis, G, Varassi G, Ciamitti B, Benzi G, Villa RF. Protezione del SNC dall'ipossia ipossica ed ischemica. Studio comparativo sull'azione dei barbiturici e dell'alfaxolone-alfadolone. Acta Anaesth. Ital., 30, 629-643 (1979).

10) Benzi G, Arrigoni E, Dagani F, Marzatico F, Curti D, Polgatti M, Villa, RF. Drug interference on the age-dependent modification of the cerebral enzymatic activities related to energy transduction. In "Aging of the Brain and Dementia" (L. Amaducci, A.N. Davison and P. Antuono, eds.), Vol. 13, pp. 113-117, Raven Press, New York (1980).

11) Benzi G, Arrigoni E, Dagani F, Marzatico F, Curti D, Polgatti M, Villa, RF. Aging.and brain enzymes. In "The Aging Brain. Neurological and Mental Disturbances" (G.

Barbagallo-Sangiorgi and A.N. Exton-Smith, eds.), pp. 1-13, Plenum Press, New York (1981).

12) Benzi G, Arrigoni E, Dagani F, Marzatico F, Curti D, Polgatti M, Villa, RF. Les modifications enzymatiques du cerveau age chez le rat. In "Souffrance Cérébrale et Précurseurs des Phospholipides", Paris (1981).

13) Benzi G, Arrigoni E, Dagani F, Marzatico F, Curti D, Polgatti M, Villa, RF, Agnoli A. Differential pharmacological action as a function of age on cerebral enzymatic activities related to energy transduction. In "Les Alpha-Bloquants: Pharmacologie Expérimentale et Clinique", pp. 362-371, Masson, Paris (1981).

14) Villa RF, Curti D, Dagani F, Polgatti M, Marzatico F, Benzi G, Rat brain cortex subfractions: action of an alpha-bloking agent on some enzymatic activities. In "Pharmacologie Expérimentale et Clinique", pp. 357-361, Masson, Paris (1981).

15) Villa RF, Curti D, Marzatico F, Polgatti M, Dagani F. Changements de certaines

activities enzymatiques dans l'ischemie cérébrale totale chez le rat. In "Souffrance Cérébrale et .Précurseurs des Phospholipides", pp. 91-101, Paris (1981).

16) Marzatico F, Arrigoni E, Curti D, Villa RF, Benzi G, Modifications produced by ischemia on some cerebral enzyme.activities related to energy transduction. It. J. Biochem., 31, 207-209 (1982).

17) Villa RF, Gorini A. Experimentacao farmacologica com CDP-colina. Acta International Congress, Lisboa (1982).

18) Benzi G, Arrigoni E, Pastoris O, Dossena M, Gorini A.Villa RF. Effects of ergot derivatives on the metabolic changes induced by acute hypoxia on the synaptosomes from dog brain. In "Aging Brain and Ergot Alkaloids" (A. Agnoli, G. Crepaldi, P.F., Spano and M. Trabucchi, eds.), Vol. 23, pp. 263-282, Raven Press, New York (1983).

19) Villa RF, Benzi G, Synaptosomes from dog cerebral cortex: action of CDP-choline and pentobarbital during hypoxia on energy metabolism. In "Cerebral Pathology in Old Age", pp. 335-342, Emiras, Pavia (1983).

20) Benzi G, Villa RF, Gorini A. Interferenza della diidroergocristina sul metabolismo energetico cerebrale. Giornale di Neuropsicofarmacologia, 5, 23-25 (1983).

21) Benzi G, Pastoris O, Villa RF. Pharmacobiological interventions of CDP-choline in hypoxia and aging of the brain. In "Novel Biochemical, Pharmacological and Clinical Aspects of Cytidine Diphosphocoline" (V. Zappia, B. Nilsson, E.P. Kennedy and P. Galletti, eds.), pp. 239-250, Elsevier, New York (1985).

22) Villa RF, Gorini A, Zanada F, Benzi G. Changes of acetylcholinesterase and (Na+K+)ATPase activities of synaptic plasma membranes from cerebral cortex of 4 and 8 month-old rats. It. J. Biochem., 35, A120 (1986).

23) Villa RF, Gorini A, Zanada, F, Benzi G. Enzyme activities in perikaryal and synaptic mitochondrial fractions from rat hippocampus. In “"Neuroendocrine System and Aging" (P. Vezzadini, A. Facchini and G. Labò, eds.) Vol. 8, pp. 199-204, Eurage (Rijswijk) (1986).

24) Benzi G, Pastoris O, Villa RF. Metabolic changes by severe hypoglycemia during brain aging. In "Modulation of Central and Pheripheral Transmitter Function" (G. Biggio, P.F. Spano, G. Toffano and G.L. Gessa, eds.), Vol. 3, pp. 283-290, Springer-Verlag, Padova (1986).

25) Benzi G, Villa RF, Pastoris O, Tentoni, S, Dossena M, Giuffrida, AM. Influence of aging on the derangement of brain bioenergetic by hypoxic insult. In "Pharmacology of Cerebral Ischemia" (J. Krieglstein, ed.), pp. 153-165, Elsevier (1986).

26) Benzi G, Pastoris O, Tentoni, S, Dossena M, Marzatico F, Villa RF. Modificazioni indotte dall'invecchiamento sul metabolismo dei lipidi cerebrali durante grave carenza di glucosio. In "Lipidi ed Invecchiamento", pp. 5-18, Abano Terme (1986).

27) Benzi G, Marzatico F, Pastoris O, Villa RF, Giuffrida, AM. Modifications des métabolismes énérgetique, lipidique et protéique et leurs roles au cours du

veillissement cérébral. In "Investigations Cliniques et Paracliniques dans le Vieillissement Cérébral", pp. 141-168, Paris (1987).

28) Giuffrida-Stella, AM, Alberghina M, Avola, R, Condorelli, DF, Ragusa N, Turpeenoja L, Vanella A, Villa RF, Benzi G, Effetto della somministrazione cronica di CDP-colina sul metabolismo degli acidi nucleici delle proteine in diverse aree cerebrali durante l'invecchiamento.Gior. Geront., XXXVI, 331-340 (1988).

29) Avola, R, Villa RF, Condorelli, DF, Turpeenoja L, L., Magrì G, Ragusa N, Giuffrida-Stella, AM. Changes of brain metabolism during aging induced by drug treatment. Advances in Miochemistry, 2, 215-220 (1989).

30) Gorini A, Arnaboldi R, Villa RF. Age-related changes in acetylcholinesterase activity od synaptic plasma membranes from rat cerebral cortex frontal area. It. J. Biochem., 38, 112A-115A (1989).

31) Battino M, Bertoli E, Formiggini G, Gorini A, Villa RF, Lenaz G. Comparative

investigations on animal mitochondria ubiquinone content. A qualitative and quantitative study. In "Highlights in Ubiquinone Research" (G. Lenaz, O. Barnabei, A. Rabbi and M. Battino, eds.), pp. 178-181, Taylor and Francis Ltd., London, (1989).

32) Avola, R, Condorelli, DF, Ragusa N, Turpeenoja L, L., Magrì G, Villa RF, Giuffrida-Stella, AM. Age dependent changes of gene expression in different brain regions. In "Role et évolution de l'animal de laboratoire dans la recherche biomédicale", pp. 75-83, Collection Fondation M. Merieux, Lyon, France, (1989).

33) Benzi G, Pastoris O, Marzatico F, Villa RF. Effect induced by oxidative stress on the cerebral glutathione system during aging. In "Role et évolution de l'animal de laboratoire dans la recherche biomédicale", pp. 197-211,, Collection Fondation M. Merieux, Lyon, France, (1989).

34) Turpeenoja, L., Villa, R.F., Lahdesmaki, P., Giuffrida-Stella, A.M.. Age-related modifications of synaptosomal plasma membranes proteins in various brain regions. Acta Neurol. Scand., 79, 262-263 (1989)

35) Benzi G, Marzatico F, Pastoris O, Villa RF. Age-related modifications of the cerebral enzyme antioxidant system in different brain regions. In "50th Anniversary of Phospholipid Research" (K.J. Gundermann and R. Schumacher, eds.),pp. 197-211, wbn-Verlag - Bingen/Rhein (1990).

36) Villa RF., Arnaboldi, R., Ghigini, B., Geroldi, D., Gorini, A. Age-related changes of enzyme activity of motochondrial populations from hippocampus and striatum. Minerva Biotech., 2, 381 (1990).

37) Villa RF, Arnaboldi R, Ghigini, B., Geroldi D, Gorini A. Effect of CDP-choline on age-related changes of non-synaptic mitochondrial enzyme systems of cerebral cortex. Pharmacol. Res., 22, 496 (1990).

38) Villa RF, Gorini A. Effect of drug treatment on age-related changes of brain enzyme activity in different mitochondrial populations Arch. Geront. Geriatr., 12(2), 557-562 (1991).

39) Benzi G, Marzatico F, Pastoris O, Villa RF. Influenza degli stress ossidativi sulle alterazioni età-dipendenti del sistema glutationico cerebrale. In “I radicali liberi in Fisiologia e Patologia”. Atti XXII Congresso Nazionale della Società Italiana per lo studio del metabolismo normale e patologico, pp. 1-19, Mattioli (1991).

40) Gazzaruso C, Villa RF, Priori F, Falcone C, Geroldi D, Fratino P. Lipoproteina (a), inibitore-1 dell’attivatore del plasminogeno e trigliceridi nella cardiopatia ischemica. Giorn. It. Chim. Clin., 17, 239-242 (1992).

41) Villa RF, Gorini A.Benzi G, Tecnologie preparativa ed analitica delle popolazioni non-sinaptiche ed intra-sinaptiche (due tipologie) dei mitocondri di corteccia cerebrale di ratto. In “Metodi di Neurobiologia”: metodi per lo studio del metabolismo cerebrale, pp. 1-7, Il Pensiero Scientifico Editore (1993).

42) Villa RF, Arnaboldi R, Ghigini B, Gorini A. Synaptic non-mitochondrial ATPase activities as a pharmacological model for the evaluation of drugs’s action on

cerebral energy metabolism during ageing British Journal of Pharmacology. Proceeding Supplement, 210P, (1993)

43) Ingrao, F., Turpeenoja, L., Villa RF, Magrì, G., Gorini, A., Reale, S., Costa, A., Ragusa, N., Avola, A., Giuffrida-Stella, A.M. Age dependent changes of mitochondrial and synaptosomal membrane protein composition in different brain regions. It. J. Biochem., 42, 148A-149A (1993).

44) Garzaniti A, Bonetti G, Buscaglia P, Villa RF, Giudici A, Gazzaruso C, Pozzi M, Geroldi D, Finardi G. Evidences for a non genetic nature of high Lp(a) levels in hemodialysis patients. It. J. Biochem., 43, 302A-303A (1994).

45) Nicoletti, V.G., Tendi, E.A., Lalicata, G., Reale, S., Costa, A., Villa RF, Guerrieri, F., Ragusa, N., Giuffrida-Stella, A.M. Modifications of mitochondrial cytochrome c oxidase and FoF1 ATP synthase subunits content in rat cerebral cortex during aging. It. J. Biochem., 44, 329-330 (1995).

46) Benzi G, Villa RF, Dagani F. Modificazioni bioenergetiche da ipossia cerebrale. Ruolo della ATPasi nel turnover del glutamato. In “Il cervello senile”; pp. 163-181, Pythagora Press (Milano) (1995).

47) Villa RF, Arnaboldi, R., Ghigini, B., Geroldi, D., Gorini, A. I sistemi enzimatici ATP-asici sinaptosomiali: un modello per la valutazione del metabolismo energetico cerebrale. In “Saggi di Neuropsicologia Infantile, Psicopedagogica e Riabilitazione”, Vol. I, pp. 1-7, Masson (1995).

48) Genova ML, Gorini A. Villa RF, Tietz, C., Pallotti F, Pugnaloni, A., Biagini G, Viticchi C, Brighetti, B., Bovina C, Lenaz G. Changes in different mitochondrial populations from cerebral cortex of aged rats. It. J. Biochem., 45, 207-208 (1996).

49) Villa RF, Ghigini B, Maggi AM, D’Angelo A, Gorini A. Synaptic plasma membranes from striatum during ageing: changes of ATPases enzymatic activities. Fundamental & Clinical Pharmacology, 223 (1996)

50) Villa RF, Maggi AM, D’Angelo A, Canosi U, Geroldi D, Gorini A. ATPases of synaptosomes, synaptic plasma membranes and synaptic vesicles during ageing and chronic hypoxia. J. Neural Transm, 103, LIII (1996)

51) Genova ML, Bovina C, Pallotti F, Carraro S, Sgarbi G, Castaldini C, Biagini G, Viticchi C, Gorini A.Villa RF, Lenaz G. Age-related changes in nonsynaptic and synaptic mitochondria from rat cerebral cortex. It. J. Biochem., 46, 148-153 (1997)

52) Battino M, Svegliati Baroni S, Littarru GP., Bompadre S, Leone L, Gorini A, Villa RF. Coenzyme Q homologs and vitamin E in synaptic and non-synaptic occipital cerebral cortex mitochondria in the aging rat. In "Molec. Aspects Med." (G.P. Littarru, R. Alleva, M. Battino, K. Folkers, eds.), Vol. 18, pp. 279-282, Pergamon Press (1997).

53) Canosi U, Gorini A, Villa RF, Geroldi D. Analysis of apolipoproteins(a) isoforms and lipoprotein(a) levels in a family.Atti della Associazione Genetica Italiana, XLIII, 35-36 (1997).

54) Villa RF, D’Angelo A, Canosi U, Geroldi D, Gorini A. Le variazioni indotte dall'invecchiamento cerebrale sulle attività catalitiche delle ATP-asi delle membrane plasmatiche sinaptiche della corteccia cerebrale frontale di ratto. Giornale di Gerontologia, XLVI, 239 (1998)

55) Villa RF, D’Angelo A, Canosi U, Geroldi D, Gorini A. Le variazioni indotte dall'invecchiamento cerebrale sulle attività catalitiche delle ATP-asi in differenti popolazioni sinaptosomiali di ippocampo. Giornale di Gerontologia, XLVI, 240 (1998)

56) Villa RF, D’Angelo A, Gorini A. Catalytic properties of ATP-ases of selected synaptosomes from hippocampus during aging. Neurosci. Lett., S52, 80-81 (1999)

57) Villa RF, D’Angelo A, Gorini A. Attività catalitiche delle ATP-asi di differenti tipi di membrane plasmatiche sinaptiche e somatiche della xcorteccia cerebrale frontale durante l'invecchiamento. Giornale di Gerontologia, XLVII, 291-292 (1999)

58) Villa RF, D’Angelo A, Devecchi E, Rancati A, Geroldi D, Gorini A. Modificazioni indotte dall'invecchiamento sulle attività delle ATP-asi delle membrane plasmatiche sinaptiche e somatiche della corteccia cerebrale. Giornale di Gerontologia, XLVII, 319(2000)

59) Battino M, Ferreiro S, Littarru GP, Quiles JL, Huertas JR, Mataix JF, Villa RF, Gorini A. Biochemical heterogeneity of brain mitochondria. Atti della "Second Conference of the International Coenzyme Q Association" Frankfurt (2000).

60) Villa RF, Gorini A. Neuronal signaling during hypoxia and pharmacological treatment. Atti del First Colloquia of the National Academy of Sciences “Neuronal Signaling” National Academy of Sciences, Washington USA (2001).

61) Gorini A, Devecchi E, Villa RF. Effect of clonidine on ATP-ases’ Activities of synaptic plasma membranes from cerebral cortex. Pharm. Res., 43, Suppl. A (2001).

62) Villa RF, Devecchi E, Gorini A. Effect of naloxone treatment on ATPases’ activities of

synaptic plasma membranes from rat hippocampus. Eur. Neuropsychopharm., 11, 321-322 (2001)

63) Villa RF, Devecchi E, Brera F, Degiuli A, D’Agostino A, D’Agostino M, Cambiè G, Gorini A. Mitochondrial energy-linked enzymes in lymphocytes during ageing as biochemical markers for drug’s action. J. Clinical Pharmac., 44, 1197 (2004)

64) Villa RF, Devecchi E, Brera F, Degiuli A, D’Agostino A, D’Agostino M, Cambiè G, Faggi L, Colturani G, Gorini A. Energy-linked enzymes in lymphocytes of patients with a diagnosis of dementia. J. Clinical Pharmac., 45, 1071 (2005)

65) Villa RF, Gorini A, Brera F, Geroldi D. Functional proteomics of lymphocytes is related to energy failure in acute stroke. Acta Pharmac. Sinica, 27, 102-103 (2006)

66) Villa, R.F., A. Gorini, D. Geroldi, G. Pero, F. Brera Energy metabolism of lymphocytes from acute stroke patients J. Cereb. Blood Flow and Metabol., 27, BP56-09M (2007)

67) Villa RF, Gorini A. Parkinson-like disease by 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) toxicity on energy-linked non-synaptic and intra-synaptic mitochondrial enzyme systems from Macaca fascicularis brain. In «Mitochondria: Structure, Functions and Dysfunctions », Oliver L. Svensson Ed., Nova Publisher, Hauppauge New York, U.S.A., (2010)

68) Villa, R.F. Handling Editor for Sensory stimulation based complete protection from ischemic stroke remains stable at 4 months post-occlusion of MCA by Hancock, A.M., Lay, C.C., Davis, M.F. and Frostig, R.D. In “Drugs for Stroke”, Roberto F. Villa, Ed., Special Issue Journal of Neurological Disorders, OMICS Publishing Group, U.S.A. (2013)

69) Ferrari, F., Geroldi D., Gorini A., Pero, G., Hoyer, S., Villa, R.F. Mitochondrial energy metabolism of brain and lymphocytes after ischemia and recovery during aging. Cerebrov. Dis, 39, S140, (2015)

70) Ferrari, F., Devecchi, E., Pero, G., Gorini, A, Villa, R.F. Bioenergetic characterization of lymphocytes from stroke patients. Cerebrov. Dis, 41, S44, (2016)

71) Villa, R.F., Ferrari, F., Moretti, A. Effects of neuroprotectants before and after stroke: statints and anti-hypertensives. In “Journal of Neurology & Neurophysiology”, Paul A. Lapchak, Editor J. Neurol. Neurophys. and Associate Editor of Translational Stroke Research, Edition 2017, U.S.A.

72) Ferrari, F., Bascì, J., Bagini, L., Viscardi, P., Pero, G., Moretti, A., Villa, R.F. Prevention of

acute and recurrent stroke by anti-hypertensives: interaction with thrombolysis.

Cerebrov. Dis, 43, S164, (2017)

73) Ferrari, F., Bagini, L., Pero, G., Moretti, A., Villa, R.F. Physiopathological mechamnisms

and pharmacological treatment of post-stroke depression Cerebrov. Dis, 45, (1),

(2018)

PPaarrttee IIIIII.. RREELLAAZZIIOONNII,, CCOOMMUUNNIICCAAZZIIOONNII ee ““PPOOSSTTEERRSS”” PPRREESSEENNTTAATTII AA CCOONNGGRREESSSSII

NNAAZZIIOONNAALLII EEDD IINNTTEERRNNAAZZIIOONNAALLII

1) Congresso Internazionale: "La Terapia Medica della Ischemia Cerebrale". Azione della (-)eburnamonina, papaverina ed UDP-glucoso sul metabolismo energetico cerebrale in condizioni di ipossia ed ischemia sperimentale. Milano, (1977).

2) II° Rencontre Franco-Italienne de Geriatrie et de Gerontologie-Psychiatrie. Effets d'un traitement expérimental au long cours sur quelques activitatés enzymatiques cérébrales. Martigues, Francia (1978).

3) Satellite Sympsosium of 7th International Congress of Pharmacology. Phenobarbital interference on cerebral metabolism related to energy transduction.

Rheims, Francia (1978). 4) 9th International Salzburg Conference on Cerebral Vascular Disease.

Influence of phenobarbital on cerebral metabolic pathways related to energy transduction. Salzburg, Austria (1978).

(1)*5) IInd European Neuroscience Meeting. Villa, R.F., Benzi, G. Pharmacological action on energy-related enzyme activities of rat brain subfractions. Firenze (1978).

6) Congresso Internazionale: "Omeostasi e Senescenza". Influenza del trattamento cronico con vari farmaci su alcune attività enzimatiche cerebrali correlate con la liberazione di energia. Parma (1978).

7) Congresso Nazionale: "L'Ischemia Cerebrale". Azioni farmacologiche sul metabolismo energetico in condizioni di ipossia ed ischemia cerebrale sperimentale. Roma (1978).

(2)*8) IIIrd European Neuroscience Meeting. Villa, R.F., Curti, D., Dagani, F., F. Marzatico A study on enzymatic activities of glycolisis, TCA cycle, electron transfer chain and cholinergic transmission in purified mitochondria and crude synaptosomes from different rat brain areas. Roma (1979).

(3)*9) IIIrd European Neuroscience Meeting. Villa, R.F., Dagani, F., Curti, D., F. Marzatico

Behaviour of some enzymatic activities related to energy transduction during experimetal ischemia in rat brain. Roma (1979).

10) Symposium International les "Alpha-boquants". Villa, R.F., Dagani, F., Curti, D., F. Marzatico Rat brain cortex subfractions: action on an alpha bloking agent on some enzymatic activities. Paris, Francia (1979).

11) Symposium International les "Alpha-boquants". Villa, R.F., Dagani, F., Curti, D., F. Marzatico Differentiated pharmacological action as a function of age on cerebral enzymatic activities related to energy transduction. Paris, Francia (1979).

(4)*12) XX Congresso della Società Italiana di Farmacologia. Curti, D., Dagani, F., Villa, R.F., G. Benzi

Stimolazione beta adrenergica ed enzimi mitocondriali e sinaptosomiali di corteccia cerebrale di ratto. Verona (1980).

(5)*13) XX Congresso della Società Italiana di Farmacologia. Dagani, F., Villa, R.F., G. Benzi Barbiturici e metabolismo cerebrale: effetto su intermedi ed enzimi. Verona (1980).

(6)*14) XX Congresso della Società Italiana di Farmacologia. Marzatico, F., Villa, R.F., G. Benzi Curve dose/azione e tempo/azione di alcune molecole biologiche valutate in vivo mediante lo studio delle attività enzimatiche sul cervello di ratto. Verona (1980).

15) Congresso Internazionale: "Deoxyglucose Uptake and Oxigen Consumption: a Metabolic Approach to Cerebral Function". Villa, R.F., G. Benzi Effect of eburnamonine on brain energy metabolism. Paris, Francia (1980).

16) Convegno Nazionale: "Cerebropatie Senili". Risposte biochimiche cerebrali differenziate in funzione dell'età. Parma (1980).

17) Congresso Internazionale: "Souffrance Cérébrale et Précurseurs des Phospholipides". Villa, R.F., G. Benzi Les modofications enzymatiques du cerveau chez le rat. Paris, Francia (1980).

18) Congresso Internazionale: "Souffrance Cérébrale et Précurseurs des Phospholipides". Villa, R.F., G. Benzi Changements de certaines activities enzymatiques dans l'ischemie cerebrale totale chez le rat. Paris, Francia (1980).

19) Congresso Internazionale: "Le Cerebropatie Croniche, Vascolari e Cellulari". Aspetti biochimici della azione dei farmaci. Stresa (1981).

(7)*20) International Symposium on "Nervous System Regeneration". Rapisarda, A., Villa, R.F., Fulle, D., Benzi, G., Giuffrida, A.M. Enzymatic activities related to energy transduction during hypoglossal nerve regeneration. Catania (1981).

21) 12° World Congress of Neurology. Villa, R.F., G. Benzi

Drug action on cerebral metabolic changes induced by acute hypoxia in dog brain synaptosomes. Kyoto, Giappone (1981).

22) 27°Congresso Nazionale Società Italiana di Biochimica: "Gruppo di Neurochimica” Dagani, F., Gorini, A., Polgatti, M., Villa, R.F., Benzi, G. Metaboliti ed attività enzimatiche cerebrali correlate con la trasduzione energetica valutate nei sinaptosomi e nei mitocondri; trattamento farmacologico. Parma (1981).

(8)*23) 27° Congresso Nazionale della Società Italiana di Biochimica. Ibidem. Dagani, F., Gorini, A., Polgatti, M., Villa, R.F., Benzi, G. Attività enzimatiche correlate con la trasduzione di energia valutate nei mitocondri liberi ed intrasinaptosomiali di corteccia cerebrale di ratto. Parma (1981).

(9)*24) 27° Congresso Nazionale della Società Italiana di Biochimica. Ibidem. Marzatico, F., Curti, D., Villa, R.F., Benzi, G.

Effetto della ischemia totale sulle attività enzimatiche connesse con la trasduzione energetica in varie frazioni subcellulari di cervello di ratto. Parma (1981).

(10)*25) 27° Congresso Nazionale della Società Italiana di Biochimica. Ibidem. Curti, D., Polgatti, M., Dagani, F., Marzatico, F., Gorini, A., Villa, R.F., Benzi, G. Caratterizzazione enzimatica di varie frazioni subcellulari in diverse zone cerebrali di ratto. Parma (1981).

(11)*26) 27° Congresso Nazionale della Società Italiana di Biochimica. Ibidem Rapisarda, A, Villa, R.F., Gorini, A., Giuffrida, A.M. Attività enzimatiche correlate con la trasduzione energetica durante i processi rigenerativi del nervo ipoglosso di coniglio. Parma (1981).

(12)*27) 27° Congresso Nazionale della Società Italiana di Biochimica. Ibidem Villa, R.F., Pastoris, O., Arrigoni, E., Benzi, G. Modificazioni età-dipendenti dello stato metabolico sinaptosomiale dell'area corticale motoria di cane. Parma (1981).

(13)*28) XXI Congresso Società Italiana di Farmacologia e Joint Meeting con la British Pharmacological Society. Villa, R.F., Gorini, A., Arrigoni, E., Benzi, G. Metabolic changes induced by hypoxia on synaptosomes from dog brain. Effect of dihydroergocristine. Napoli (1981).

29) International Seminary at "Max Plank Institut fur Biophysikalische Chemie, Abteilung Neurochemie". Villa, R.F.. Cerebral energy metabolism. Gottingen, Germania Ovest (1982).

30) Convegno di Aggiornamento della Società Italiana di Farmacologia. Interferenza della diidroergocristina sul metabolismo energetico cerebrale. Torino (1982).

31) Symposium International Startonyl. CDP-choline: experimental pharmacology. Lisboa, Portogallo (1982).

32) Meeting of Neuropharmacology. Modificazioni delle attività enzimatiche cerebrali indotte dalla somministrazione ripetuta di farmaci potenzialmente attivi sul metabolismo energetico cerebrale. Urbino (1982).

(14)*33) Fourth Meeting of the European Society for Neurochemistry. Villa, R.F., Gorini, A., Pastoris, O., Arrigoni, E. Metabolic changes induced by acute hypoxia on synaptosomes from cerebral cortex. Catania (1982).

(15)*34) Fourth Meeting of the European Society for Neurochemistry. Villa, R.F., Curti, D., Gorini, A. Effect of CDP-Choline and SAMe on some enzymatic activities in synaptosomes and mitochondria from adult rat brain cerebral cortex. Catania (1982).

(16)*35) Special Joint Meeting on "Energy Transduction and Neurotrasmission". Villa, R.F. Effect of ischemia and pharmacological treatment on enzyme activities of cortical mitochondria and synaptosomes. Roma (1982

(17)*36) Special Joint Meeting on "Energy Transduction and Neurotrasmission".

Arrigoni, E., Dagani, F., Marzatico, F., Curti, D., Gorini, A., Villa, R.F. Effect of hypoxia and pharmacological treatment on some enzyme activities from various areas of dog brain. Roma (1982).

37) International Multidisciplinary Seminary on "Cerebral Pathology in Old Age". Villa, R.F., Benzi, G. Synaptosomes from dog cerebral cortex: action of CDP-choline and pentobarbital during hypoxia on energy metabolism. Pavia (1982).

(18)*38) IInd Satellite Symposium of the International Society of Cerebral Blood Flow and Metabolism. Villa, R.F., Benzi, G., Arrigoni, E. Effect of hypoxia and pharmacological treatment on some enzyme activities from

dog brain areas. San Remo (1983).

(19)*39) 29° Congresso Nazionale della Società Italiana di Biochimica. Villa, R.F., Gorini, A. Effetto della L-acetilcarnitina sulla attività di alcuni enzimi dei mitocondri sinaptici e non-sinaptici di ippocampo di ratto. Saint Vincent (1983).

(20)*40) 29° Congresso Nazionale della Società Italiana di Biochimica: "Gruppo di Neurochimica della International Society for Neurochemistry". Villa, R.F., Gorini, A. Mitocondri sinaptici e non-sinaptici estratti da ippocampo di ratto: caratterizzazione enzimatica. Saint Vincent (1983).

41) International Symposyum "Suloctidil e Invecchiamento Cerebrale". Fattori metabolici nell'invecchiamento cerebrale. Ischia (1984).

(21)*42) 30° Congresso Nazionale della Società Italiana di Biochimica: "Gruppo di Neurochimica della International Society for Neurochemistry". Villa, R.F., Gorini, A. Azione della L-acetilcarnitina sulle attività enzimatiche delle popolazioni mitocondriali di ippocampo. Lacco Ameno d'Ischia (1983).

(22)*43) 30° Congresso Nazionale della Società Italiana di Biochimica. Ibidem. Gorini, A., Villa, R.F., Dell’Orbo, C., Zanada, F., Benzi, G. Caratterizzazione enzimatica dei mitocondri sinaptici e non sinaptici di ippocampo di ratto di 2 e 4 mesi.

Lacco Ameno d'Ischia (1983). (23)*44) International Congress on "Novel, Biochemical, Pharmacological and Clinical Aspects

of Cytidine Diphosphocholine". Benzi, G., Pastoris, O., Villa, R.F. Pharmacobiological interventins of CDP-choline in hypoxia and aging of the brain. Sorrento (1984)

45) 4th Capo Boi Conference on Neurosciences. Metabolic changes by severe hypoglycemia during brain aging. Villasimius (1985).

46) 31° Congresso Nazionale della Società Italiana di Biochimica: "Gruppo di Neurochimica della International Society for Neurochemistry". Changes of acetylcholinesterase and Na+-K+(ATP)ase activities of synaptic plasma membranes from cerebral cortex of 4 and 8 month-old rats. Rimini (1985).

(24)*47) International Symposium on "New Trends in Aging Research". Villa, R.F., Gorini, A., Zanada, F., Benzi, G.

Mitochondrial enzyme activities in perikaryal and synaptic fractions. Bologna (1985).

48) Nootropika Symposium. Hypoxic alterations of brain bioenergetics during aging and drug treatment. Dresden, Germania Est (1986).

49) Congresso della Comunità Economica Europea: "Lipidi e Invecchiamento". Modificazioni indotte dall'invecchiamento sul metabolismo dei lipidi cerebrali durante grave carenza di glucoso. Abano Terme (1986).

50) Meeting on "Metabolism and Energy Production in Aging Brain". Influence of aging on cerebral utilization of alternative sources to glucose during hypoglycemia and post hypoglycemic recovery. Roma (1986).

(25)*51) International Symposium on "Pharmacology of Cerebral Ischemia". Benzi, G., Villa, R.F., Pastoris, O., Giuffrida, A.. Influence of aging on the derangement of brain bioenergetics by hypoxic insult. Marburg, Germania Est (1986).

52) 32° Congresso della Società Italiana di Biochimica. Modificazioni dei processi bioenergetici cerebrali durante l'invecchiamento. Naxos (1986).

(26)*53) Sixth General Meeting of European Society for Neurochemistry. Turpeenoja, L., Lahdesmaki, P., Villa, R.F., Giuffrida, A.M. Modifications of synaptosomal plasma membrane proteins during aging . Prague, Cecoslovacchia (1986).

54) 2nd Joint Meeting on "Cerebral Metabolism in Aging and Neurological Disease". Energetic state of aged brain during hypoxia. Baden-Wien, Austria (1986).

(27)55) 2nd Joint Meeting on "Cerebral Metabolism in Aging and Neurological Disease". Vanella, A., Gorini, A., Campisi, A., Villa, R.F. Superoxide dismutase and cytochrome oxidase activities in synaptic mitochondria from rat cerebral cortex at different ages. Baden-Wien, Austria (1986).

(28)56) IIe Symposium International sur les Expressions Métaboliques et Tissulaires de l'Ischémie Cérébrale et de la Maladie d'Alzheimer. Villa, R.F., Pastoris, O., Benzi, G. Effect du vieillissemnt et de divers agents pharmcologiques sur le metabolisme energetique cérébral au cours de la récuperation post-hypoglycémique chez le rat. Madrid, Spagna (1986).

(29)*57) International Symposium on "New Trends in Aging Research". Turpennoja, L., Benzi, G., Villa, R.F., Magrì, G., Giuffrida-Stella, A.M. Changes of mitochondrial inner membrane proteins in rat cerebellum during aging. Sirmione (1987).

(30)*58) International Society for Neurochemistry-American Society for Neurochemistry 1987: "Joint Meeting". Benzi, G., Villa, R.F. Influence of aging and pharmacological treatment on brain energy metabolism during post-hypoglycemic recovery. La Guaira, Venezuela (1987).

(31)*59) International Society for Neurochemistry-American Society for Neurochemistry 1987: "Joint Meeting". Turpennoja, L., Villa, R.F., Benzi, G., Lhdesmaki, P., Giuffrida-Stella, A.M. Changes in cerebellar mitochondrial proteins during aging. La Guaira, Venezuela (1987).

(32)*60) 33° Congresso Nazionale della Società Italiana di Biochimica: "Gruppo di Neurochimica della International Society for Neurochemistry".

Gorini, A., Arnaboldi, R., Villa, R.F. Variazioni sull'attività dell'enzima acetilcolinesterasi indotte dall'età nelle membrane plasmatiche sinaptiche di corteccia frontale. Brescia-Gardone Riviera (1987).

(33)*61) 33° Congresso Nazionale della Società Italiana di Biochimica. Ibidem. Turpeenoja, L., Villa, R.F., Magrì, G., Giuffrida-Stella, A.M. Modificazioni delle proteine delle membrane mitocondriali del cervelletto di ratto durante l'invecchiamento. Brescia-Gardone Riviera (1987).

(34)*62) VII South-East European Conference for Neurology and Psychiatry (Thessaloniki Conference):"Aging Brain: New Trend in Neurology and Psychiatry, Cerebrao Vascular Disease, Dementia and Depression". Villa, R.F., Gorini, A.

Effect of drug treatment on age-related changes of brain enzyme activity in different mitochondrial populations. Roma (1987).

63) VII South-East European Conference for Neurology and Psychiatry (Thessaloniki Conference):"Aging Brain: New Trend in Neurology and Psychiatry, Cerebrao Vascular Disease, Dementia and Depression". CDP-choline action on the cerebral bioenergetics during aging. Roma (1987).

64) 33° Congresso Nazionale della Società Italiana di Biochimica: "Gruppo di Neurochimica della International Society for Neurochemistry". Age-related changes in acetylchonesterase activity of synaptic plasma membranes from rat cerebral cortex frontal area. Perugia (1988).

(35)*65) 14th International Congress of Biochemistry. Battino, M., Bertoli, M., Marchetti, C., Bovina, G., Formiggini, G., Villa, R.F., Gorini, A., Benzi, G., Lenaz., G. Respiratory chain features of synaptic and non-synaptic mitochondria from rat brain regions. Praga, Cecoslovacchia (1988).

(36)*66) Third Joint Meeting on "Neurochemical Approaches to the Understanding of Cerebral Disorders". Turpennoja, L., Villa, R.F., Lhdesmaki, P., Giuffrida-Stella, A.M. Age-related modifications of synaptosomal plasma membrane proteins in various brain regions. Helsingor-Copenaghen, Danimarca (1988).

(37)*67) International Symposium "Biochemistry, Bioenergetics and Clinical Applications of Ubiquinone". Battino, M., Bertoli, E., Gorini, A., Villa, R.F., Benzi, G., Bovina, C., Sassi, S., Formiggini, G., Marchetti, M., Barzanti, V, Lenaz., G. Different structural and functional aspects of synaptic and non-synaptic rat brain mitochondria. Bologna (1989).

(38)*68) XIV International Symposium on Cerebral Blood Flow and Metabolism. Pastoris, O., Marzatico, M., Dossena, M., Vercesi, L., Villa, R.F., Benzi, G. Ageing and the cerebral enzymatic antioxidant system. Bologna (1989).

(39)*69) XIV International Symposium on Cerebral Blood Flow and Metabolism. Villa, R.F., Gorini, A. Age-related changes on enzyme activity of perikaryal and synaptic mitochondria from hippocampus and striatum. Bologna (1989).

(40)*70) International Symposium "Molecular Organization of Biological Structures".

Battino, M., Bertoli, E., Formiggini, G., Gorini, A., Villa, R.F., Lenaz., G. Respiratory chain features of synaptic and non-synaptic rat brain mitochondria. A characterization study. Moscow, Unione Sovietica (1989).

(41)*71) 19th Meeting of the Federation of European Biochemical Societies. Formiggini, G., Battino, M., Bertoli, E., Gorini, A., Villa, R.F., Lenaz., G. A characterization study on respiratory chain.features of synaptic and non-synaptic rat brain mitochondria. Roma, (1989).

72) Post 19th Meeting of the Federation of European Biochemical Societies. Age-dependent changes of nucleic acid and protein metabolism in different brain regions: effect of CDP-choline treatment. Catania, (1989).

73) 3rd Congress of the International Society for Myochemistry. Changes of brain metabolism during aging induced by drug treatment. Nice, Francia (1989).

(42)*74) Riunione Annuale del Gruppo Italiano - Studio dell'Invecchiamento Cerebrale. Pastoris, O., Marzatico, F., Dossena, M., Vercesi, L., Villa, R.F., Benzi G. Invecchiamento ed attività enzimatiche del sistema antiossidante cerebrale. Como (1989).

75) Third Conference of Institute of Developmental Neuroscience and Aging. Plasticity and regeneration of the nervous system. Torino (1990).

(43)*76) European Congress on Geriatric Treatment "The Elderly at Risk". Villa, R.F., Gorini, A. Effect of L-acetylcarnitine on age-related changes of brain enzyme activity in mitochondrial populations. Catania (1990).

(44)*77) 35° Congresso Nazionale della Società Italiana di Biochimica and Joint Symposia Italian Biochemical Society - Dutch Biochemical Society - Union of Biochemical Societies of Yugoslavia. Villa, R.F., Arnaboldi, R., Ghigini, B., Geroldi, D., Gorini, A. Age-related changes of enzyme activity of mitochondrial populations from hippocampus and striatum. Bari, (1990).

(45)*78) 35° Congresso Nazionale della Società Italiana di Biochimica . Ibidem. Magrì, G., Ingrao, L., Turpeenoja, L., Villa, R.F., Gorini, A., Costa, S., Renis, S., Condorelli, D.F., Avola, R., Ragusa, N., Giuffrida-Stella, A.M. Effect of aging and hypoxia on mitochondrial and synaptosomal protein

composition in various rat brain regions. Bari, (1990).

79) XXII Congresso Nazionale della Società Italiana per lo Studio del Metabolismo Normale e Patologico. Influenza degli stress ossidativi sulle alterazioni età-dipendenti del sistema glutationico cerebrale. Palermo, (1990).

80) XXV National Congress of the Italian Society of Pharmacology. Effect of CDP-choline on age-related changes of non-synaptic mitochondrial enzyme systems of cerebral cortex. Giardini-Naxos, Taormina, (1990).

(46)*81) Fourth Meeting of the Italian Society of Neuroscience. Villa, R.F., Arnaboldi, R., Ghigini, B., Gorini, A. Age related changes of enzyme activities in mitochondrial populations from hippocampus and striatum. Palermo, (1990).

(47)*82) 5th World Congress of Biological Psychiatry. Villa, R.F., Gorini, A. Ageing and enzyme profiles of different mitochondria types from rat and Macaca Fascicularis brain areas. Firenze, (1991).

(48)*83) 5th World Congress of Biological Psychiatry. Gorini, A., Ghigini, B.,. Arnaboldi, R., Villa, R.F.. Energy-linked enzyme of synaptic plasma membranes from rat and Macaca Fascicularis brain areas. Firenze, (1991).

(49)*84) 5th World Congress of Biological Psychiatry. Geroldi, D., Arnaboldi, R., Ghigini, B.,. Luce, G.G., Marti, G., Gorini, A., Villa, R.F. Ageing and RNA profiles of rat brain cerebral cortex. Firenze, (1991).

(50)*85) 13th Biennal Meeting of the International Society for Neurochemistry. Villa, R.F., Arnaboldi, R., Ghigini, B., Gorini, A. Enzyme profiles of different mitochondria from Macaca Fascicularis cerebral cortex and action of diidroergocriptine. Sydney, Australia (1991).

(51)*86) 36° Congresso Nazionale della Società Italiana di Biochimica: "Gruppo di Neurochimica della International Society for Neurochemistry". Villa, R.F., Arnaboldi, R., Ghigini, B., Quacci,, D., Gorini, A. Enzymatic and morphological characterization of synaptosomes subtypes from rat cerebellum. Ferrara, (1991).

(52)*87) 36° Congresso Nazionale della Società Italiana di Biochimica: "Gruppo di Neurochimica della International Society for Neurochemistry". Villa, R.F., Ingrao, L., Magrì, G., Gorini, A., Turpeenoja, L., Reale, S., Costa, S., Ragusa, N., Avola, R., Giuffrida-Stella, A.M. Changes of mitochondrial and synaptosomal protein composition in different brain regions during aging: effect of CDP-choline. Ferrara, (1991).

88) Società Italiana di Biochimica: “Riunione del Gruppo di Neurochimica della International Society for Neurochemistry” Modificazioni delle proteine delle membrane mitocondriali e sinaptosomiali in varie regioni cerebrali durante l’invecchiamento: effetto della CDP-colina. Lipari, 1992

(53)*89) First IUBMB Conference: “Chemistry of Disease” Villa, R.F., Arnaboldi, R., Ghigini, B., Geroldi,, D., Gorini, A.

Mitochondrial factors in Parkinson’s disease by MPTP toxicity in Macaca fascicularis and role of glutamate. Nagoya, Giappone (1992).

(54)*90) First IUBMB Conference: “Chemistry of Disease” Geroldi, D., Cortello, F., Priori, F., Villa, R.F., Malamani, G.D., Gazzaruso, C. Clinical significance of lipoprotein(a) in essential hypertension. Nagoya, Giappone (1992).

(55)*91) 37° Congresso Nazionale della Società Italiana di Biochimica. Geroldi, D., Gazzaruso, C., Priori, F., Cappelletti, E., Cazzalini, C., Buscaglia, F., Villa, R.F. Assay of lipoprotein (a) in several pathological conditions. Perugia, (1992).

(56)*92) 37° Congresso Nazionale della Società Italiana di Biochimica. Villa, R.F., Arnaboldi, R., Ghigini, B., Geroldi, D., Gorini, A. Mitochondrial factors in Parkinson’s disease by MPTP toxicity in Macaca Fascicularis and role of glutamate.

Perugia, (1992). (57)*93) XXVI Congresso della Società Italiana di Farmacologia.

Villa, R.F., Arnaboldi, R., Ghigini, B., Gorini, A. Age-related changes of enzyme activities of non-synaptic and synaptic mitochondria of cerebral cortex and CDP-choline. Napoli, (1992).

(58)*94) Collegium Internationale Neuro-Psychoparmacologicum: President’s Workshopon “Recent Advances in the treatment of neurodegenerative disorders and cognitive dysfunction”. Villa, R.F., Arnaboldi, R., Ghigini, B., Gorini, A. Synaptosomal non-mitochondrial ATPase activities as a pharmacological model for the evaluation of drug’s action on cerebral energy metabolism. Capri, (1993).

(59)*95) Consiglio Nazionale delle Ricerche - Progetto Finalizzato Invecchiamento. Giuffrida-stella, A.M., Ragusa, N., Avola, R., Condorelli, D.F., Ingrao, F., Costa, A., Reale, S., Villa, R.F., Gorini, A., Benzi, G., Guerreri, F., Capozza, G., Zanoni, F., Papa, S. Modificazioni nella composizione delle proteine mitocondriali e sinaptosomiali, dell’ATP sintetasi e dei processi bioenergetici cerebrali durante l’invecchiamento Roma, (1993).

96) Riunione Monotematica Nazionale della Società Italiana di Farmacologia: “Meccanismi e basi razionali del trattamento farmacologico del danno tessutale da ischemia”. Siena, (1993).

(60)*97) International Symposium on: “The Lipid Triad (Triglycerides, HDL, LDL) and Cardiovascular Diseases”. Geroldi, D., Buscaglia, P., Malamani, G.D., Villa, R.F., Bonetti, G., Mariotti, S., Frattino, P. Risk factors for coronary heart disease: role of apo(a) isoforms. Milano, (1993).

(61)*98) 38° Congresso Nazionale della Società Italiana di Biochimica. Castelluccio, C., Baracca, A., Barogi, S., Bovina, C:, Calazzoni, M., Fato, R., Genova, M.L., Merlo Pich, M., Marchetti, M., Pallotti, F., Parenti-Castelli. G., Biagini, G., Gorini, A., Villa, R.F., Rugolo, M., Lenaz, G. Considerations on mitochondrial functional changes in aging. Trieste, (1993).

(62)*99) 38° Congresso Nazionale della Società Italiana di Biochimica. Villa, R.F., Arnaboldi, R., Ghigini, B., Geroldi, D., Gorini, A. Synaptosomal non-mitochondrial ATPase activities as a model for the evaluation of the cerebral energy metabolism.

Trieste, (1993). (63)*100) 38° Congresso Nazionale della Società Italiana di Biochimica.

Geroldi, D., Bellotti, B., Buscaglia, P., Bonetti, G., Capriaoli, A., Gazzaruso, C., Villa, R.F. Fratino, P. Characterization of apo(a) polymorphism in an italian population sample. Trieste, (1993).

(64)*101) V Joint Meeting Between the British and Italian Societies of Pharmacology. Villa, R.F., Arnaboldi, R., Ghigini, B., Gorini, A. Synaptic non-mitochondrial ATPase activities as a pharmacological model for the evaluation of drug’s action on cerebral energy metabolism during ageing. Roma, (1993).

(65)*102) III Meeting on: “New Perspectives in Ischemic Heart Disease, Heart Failure, Atherosclerosis and Hypertension Geroldi, D., Falcone, C., Villa, R.F., Bonetti, G., Auguadro, C., Gatti, G., Gazzaruso, C., Buscaglia, P., Frattino, P.

Lp(a) concentration and Apo(a) isoforms in patients with coronary heart disease (CHD) documented by angiography. Bologna, (1993).

(66)*103) 39° Congresso Nazionale della Società Italiana di Biochimica. Benzi, G., Curti, D., Pastoris, O., Marzatico, F., Dagani, F., Villa, R.F. Perspective for a possible pharmacological intervention on the mitochondrial complex damages by brain aging or cerebral diseases. Pavia, (1994).

(67)*104) 39° Congresso Nazionale della Società Italiana di Biochimica: "Gruppo di Neurochimica della International Society for Neurochemistry". Villa, R.F., Arnaboldi, R., Ghigini, B., Geroldi, D., Gorini, A. Energy-linked enzyme systems of “large” and “small” synaptosomes of hippocampus during aging.

Pavia, (1994). (68)*105) 39° Congresso Nazionale della Società Italiana di Biochimica.

Buscaglia, P., Gazzaruso, C., Bonetti, G., Garzaniti, A., Villa, R.F., Jucci, A., Falcone, C., Geroldi, D. Relationship between APO(a) isoforms and LP(a) concentration in several pathological conditions. Pavia, (1994).

(69)*106) XXVII Congresso della Società Italiana di Farmacologia. Villa, R.F., Arnaboldi, R., Ghigini, B., Gorini, A. Synaptosomal ATPase enzymatic activities as a model for evaluating drug’s action on cerebral energy metabolism Torino, (1994).

(70)*107) Riunione Gruppo di Studio sul “Diabete ed Aterosclerosi” Buscaglia, P., Vandelli, G., Porta, A., Gazzaruso, C., Garzaniti, A., Bonetti, G., Palumbo, P., Villa,R.F., Ranieri, G., Geroldi, D., Frattino, P. Lp(a) e retinopatia diabetica nel diabete mellito di tipo 2. Parma, (1994).

(71)*108) Riunione della Società Italiana di Neuroscienze: “Modelli Sperimentali in Neurologia e Psichiatria” Villa, R.F., Arnaboldi, R., Ghigini, B., Geroldi, D., Gorini, A. I sistemi enzimatici ATPasici sinaptosomiali: un modello per la valutazione del metabolsimo energetico cerebrale. Bosisio Parini, (1994).

(72)*109) 3rd International Symposium on “Multiple Risk Factors in Cardiovascular Disease: Vascular and Organ Protection” Geroldi, D., Bonetti, G., Gazzaruso, C., Garzaniti, A., Buscaglia, P., Chioffi, M.,

Auguadro, C., Villa, R.F., Falcone, C., Frattino, P., Finardi, G. Low MW apo(a) isoforms as genetic risk factor for restenosis Firenze, (1994).

(73)*110) IV Riunione dell’Associazione Italiana per Ricerca sull’ Invecchiamento Cerebrale. Arnaboldi, R., Gorini, A., Ghigini, B., Geroldi, D., Villa, R.F., Subtypes of hippocampal synaptosomes: energy-linked enzymes during ageing. Como, (1995).

(74)*111) Meeting di Aggiornamento Tosco-Umbro Bonetti, G., Garzaniti, A., Gazzaruso, C., Buscaglia, P., Giudici, A., Jucci, A., Villa, R.F., Frattino, P., Geroldi, D. Lipoproteina (a): nuovo fattore di rischio aterogeno Siena, (1995).

(75) *112) First European Congress of Pharmacology Villa, R.F., Arnaboldi, R., Ghigini, B., Geroldi, D., Gorini, A. Synaptic plasma membranes ATPases activities during ageing of cerebral specific functional areas.

Milano, (1995). (76)*113) VI Congresso della Società Italiana di Neuroscienze

Villa, R.F., Arnaboldi, R., Ghigini, B., Geroldi, D., Gorini, A. I sistemi enzimatici ATPasici delle membrane plasmatiche sinaptiche: un modello per la valutazione del metabolismo energetico cerebrale. Milano, (1995).

(77)*114) 40° Congresso Nazionale della Società Italiana di Biochimica Genova, M.L., Merlo Pich, M., Gorini, A., Villa, R.F., Tietz, C., Lenaz, G. Decrease of rotenone sensitivity of NADH-coenzyme Q reductase in brain cortex mitochondria from aged rats. Torino, (1995).

(78)*115) 40° Congresso Nazionale della Società Italiana di Biochimica: "Gruppo di Neurochimica della International Society for Neurochemistry". Villa, R.F., Milesi, G., Ghigini, B., Geroldi, D., Gorini, A. Energy-utilizing ATPases activities of synaptic plasma membranes during ageing of striatum. Torino, (1995).

(79)*116) 40° Congresso Nazionale della Società Italiana di Biochimica: "Gruppo di Neurochimica della International Society for Neurochemistry". Nicoletti, V.G., Tendi, E.A., Lalicata, C., Reale, S., Costa, A., Villa, R.F., Ragusa, N., Giuffrida-Stella, A.M. Influence of aging on cytochrome c oxidase and F0F1 ATP Synthase subunit content in rat cerebral cortex. Torino, (1995).

117) Forum della Accademia Nazionale di Medicina: “Sclerosi Multipla: Basi Razionali delle Moderne Terapie”. Sclerosi Multipla: Basi Razionali delle Moderne Terapie Varese (1995)

118) Cellular and Molecular Pharmacology Center in Milan Cellular and Molecular Pharmacology in Milan Milano (1996)

119) 9th International Symposium “Biomedical and Clinical Aspects of Coenzyme Q” Ubiquinone and Nervous System Villa, R.F. Co-chairperson of the session Ancona (1996)

(80)*120) 9th International Symposium on“Biomedical and Clinical Aspects of Coenzyme Q” Battino, M., Svegliati-Baroni, S., Bompadre, S., Leone, L., Littarru, G..P., Gorini, A., Villa, R.F. Coenzyme Q homologs and vitamin E in synaptic and non-synaptic occipital

cerebral cortex mitochondria in the ageing rat Ancona (1996)

(81)*121) 3rd Joint Meeting of the French and Italian Pharmacological Societies Villa, R.F., Ghigini, B, Maggi, A., D’Angelo, A., Gorini, A. Synaptic plasma membranes from striatum during ageing: changes of ATP-ases enzymatic activities. Capri (1996)

122) Convegno Internazionale I.R.C.C.S. e Università di Pavia - Neurochorurgia Il trapianto di cellule nervose nella ricerca e nella clinica: terapia ricostruttiva - terapia genica Pavia (1996)

(82)*123) 41° Congresso Nazionale della Società Italiana di Biochimica: “Advances in Protein Biochemistry” Villa, R.F., Maggi, A., D’Angelo, A., Canosi, U., Geroldi, D., Gorini, A. ATPases activities of synaptic plasma membranes during ageing Catania (1996)

124) International Congress on New Trends in Biotechnology, Science and Education Agrobiotechnology, archeobiotechnology, biocatalysis, biotechnology and cosmetics, new products and methodologies. Capri (1996)

(83)*125) Third Congress of the European Society for Clinical Neuropharmacology Villa, R.F., Maggi, A., D’Angelo, A., Canosi, U., Geroldi, D., Gorini, A.

ATP-ases of synaptosomes, synaptic plasma memebranes and synaptic vesicles during ageing and chronic hypoxia.

Roma (1996) (84)*126) Congresso Nazionale della Società Italiana di Gerontologia e Geriatria

Villa, R.F., Maggi, A., D’Angelo, A., Canosi, U., Geroldi, D., Gorini, A. Modificazioni indotte dell’invecchiamento sull’attività catalitica delle ATPasi in differenti popolazioni sinaptosomiali di ippocampo

Firenze (1996) 127) Seminario presso la Facoltà di Scienze dell’Università degli Studi di Ancona

Isolamento di popolazioni mitocondriali sinaptiche e non sinaptiche e caratterizzazione della attività ATPasica nell’invecchiamento cerebrale Ancona (1997)

(85)*128) International Congress New Trends in Biotechnology Science and Education Villa, R.F., Gorini, A. Catalytic and molecular biological properties of ATP-ases: an approach for the study of cerebral degenerative diseases Capri (1997)

(86)*129) II Workshop dell’Istituto Nazionale Biostrutture e Biosistemi Genova, M.L., Gorini, A., Villa, R.F., Tietz, C., Pallotti, F., Pugnaloni, A., Biagini, G., Viticchi, C., Bovina, C., Lenaz., G. Modificazioni della catena respiratoria in diverse popolazioni mitocondriali di corteccia cerebrale di ratti invecchiati Ancona (1997)

130) "Gruppo di Neurochimica della International Society for Neurochemistry". Poliammine e Neurochimica - Progressi della Ricerca Biologica e Clinica S. Marinella (Roma) (1997)

131) Congresso a Milano La scienza Milano (1997)

132) Congresso a Bologna I mitocondri Bologna (1997)

(87)*133) 42° Congresso Nazionale delle Società Italiana di Biochimica - Joint Symposia Israel Society for Biochemistry and Molecular Biology Genova, M.L., Gorini, A., Villa, R.F., Tietz, C., Pallotti, F., Pugnaloni, A., Biagini, G., Viticchi, C., Formiggini, G., Bovina, C., Lenaz., G. Changes in NADH oxidation in different mitochondrial populations in the cerebral cortex from aged rats Ancona (1997)

(88)*134) 42° Congresso Nazionale delle Società Italiana di Gerontologia e Geriatria Villa, R.F., D’Angelo, A., Canosi, U., Geroldi, D., Gorini, A. Le variazioni indotte dall’invecchiamento cerebrale sulle attività catalitiche delle ATP-asi delle membrane plasmatiche sinaptiche di corteccia cerebrale frontale Roma (1997)

135) 42° Congresso Nazionale delle Società Italiana di Biochimica - Joint Symposia Israel Society for Biochemistry and Molecular Biology Relazione su: “L’invecchiamento della membrana sinaptica: aspetti morfo-funzionali Ancona, 1997

136) Convegno Congiunto Associazione Genetica Italiana - Società Italiana di Mutagenesi Ambientale Analysis of apolipoprotein (a) isoforms and lipoprotein(a) levels in a family Orvieto (1997)

(89)*137) 42° Congresso Nazionale della Società Italiana di Gerontologia e Geriatria. Modificazioni indotte dall'invecchiamento sulla attività catalitica delle ATP-asi in differenti popolazioni sinaptosomiali di ippocampo. Roma (1997)

(90)*138) Biomedicina '97: "Meeting on molecular medicine" Villa, R.F., D’Angelo, A., Canosi, U., Gorini, A. Cerebral degenerative diseases: catalytic and molecular biological properties of ATP-ases. Firenze (1997)

(91)*139) 8° Congresso della Società Italiana di Psichiatria Biologica Gorini, A., D’Angelo, A., Geroldi, D., Villa, R.F. Effetto del naloxone sui sistemi ATPasici delle membrane plasmatiche sinaptiche di corteccia cerebrale frontale. Napoli (1998)

(92)*140) 28th Annual Meeting of the Society for Neurosciences U.S.A.. Gorini, A., D’Angelo, A., Villa, R.F. Age-related changes of ATP-ases activities of synaptic plasma membranes from rat cerebral cortex. Los Angeles, U.S.A. (1998)

(93)*141) 28th Annual Meeting of the Society for Neurosciences U.S.A.. Gorini, A., D’Angelo, A., Villa, R.F. Age related changes of enzyme activities of mitochondrial populations from rat cerebral cortex. Los Angeles U.S.A. (1998)

142) 43° Congresso Nazionale della Società Italiana di Gerontologia e Geriatria Attività catalitiche delle ATP-asi di differenti tipi di membrane plasmatiche sinaptiche e somatiche di corteccia cerebrale frontale durante l'invecchiamento. Firenze (1998)

(94)*143) Biomedicina '98: "Meeting on Molecular Medicine" Villa, R.F., Gorini, A., D’Angelo, A., Geroldi, D., Canosi, U., Catalytic and molecular properties of ATP-ases during aging of cerebral tissue. Firenze (1998)

144) International Conference of "Genes and Crystals" Pavia (1998)

(95)*145) Stroke '99: Meeting on Cerebrovascular Diseases Gorini, A., D’Angelo, A., Villa, R.F. Adattamento delle proprietà catalitiche delle ATPasi delle membrane plasmatiche sinaptiche e delle vescicole all'invecchiamento ed alla ipossia ipossica. Firenze (1999)

(96)*146) First Annual Meeting of American Society for Experimental NeuroTherapeutics. Villa, R.F., D’Angelo, A., Gorini, A. ATP-ases activities of synaptosomes, synaptic plasma membranes and synaptic vesicles from rat cerebral cortex during ageing and experimental hypoxia.. Washington D.C., U.S.A. (1999),

(97)*147) New York Academy of Science: "Oxidative Energy Metabolism in Neurodegenerative Disorders" Villa, R.F., D’Angelo, A., Gorini, A. ATP-ases of synaptic plasma membranes and vesicles from rat cerebral cortex during ageing and hypoxia. New York, U.S.A. (1999)

148) International Congress on: "Gene delivery into the Central Nervous System".

Pavia (1999) (98) *149) Joint Symposia: "Italian Biochemical Society - Sociedad Espanola de Bioquimica y

Biologia Molecular - Italian Society of Experimental Biology". Villa, R.F., D’Angelo, A., Geroldi, D., Gorini, A. Adaptation of ATP-ases of synaptic plasma membranes and synaptic vesicles to hypoxia during ageing. Alghero (1999)

(99)*150) 8th National Congress of the Italian Society for Neurosciences. Villa, R.F., D’Angelo, A., Gorini, A. Catalytic properties of ATP-ases of selected synaptosomes from hippocampus during ageing. Roma (1999)

(100)*151) 29th Annual Meeting of Society for Neurosciences. Villa, R.F., D’Angelo, A., Gorini, A. ATP-ases activities during ageing of different types of synaptic plasma membranes from rat cerebral cortex. Miami, U.S.A. (1999)

(101)*152) 29th Annual Meeting of Society for Neurosciences. Gorini, A., D’Angelo, A., Villa, R.F. Enzyme activities of cerebral cortex mitochondria during aging of hypertensive rats. Miami, U.S.A. (1999)

153) 44° Congresso Nazionale della Società Italiana di Gerontologia e Geriatria. Modificazioni indotte dall'invecchiamento sulle attività delle ATP-asi delle membrane plasmatiche sinaptiche e somatiche della corteccia cerebrale. Napoli (1999)

(102)*154) Biomedicina '99: "Meeting on Molecular Medicine" Gorini, A. D’Angelo, A., Devecchi, E., Rancati, A., Villa, R.F. Catalytic properties of ATP-ases of selected synaptosomes from hippocampus during aging. Firenze (1999)

155) Italian Group for Pharmacoeconomic Studies. Workshop on the Harmonization of drug pricing and remboursement procedures. Pavia (1999)

156) International Symposium on the "The photon century: updating and new trends in Light Microscopy". Workshop on the "Oxidative stress in ageing and pathology". Pavia (2000)

157) Seminario "La sperimentazione clinica: aspetti metodologici , etici e normativi". Pisa (2000)

(103)*158) XV Corso di Aggiornamento della Società italiana di Neurologia. Villa, R.F., D’Angelo, A., Devecchi, E., Gorini, A. ATP-ases of synaptic plasma membranes and synaptic vesicles during ageing and experimental hypoxia. Milano (2000)

(104)*159) 45° Congresso Nazionale Società Italiana di Biochimica e Biologia Molecolare. Gorini, A., D’Angelo, A., Devecchi, E., Villa, R.F. ATP-ases activities during aging in somatic and synaptic plasma membranes from cerebral cortex. Napoli (2000)

(105)*160) 29th Annual Meting of Society for Neurosciences. Villa, R.F. D’Angelo, A., Devecchi, E., Gorini, A. ATP-ases activities during aging of synaptic plasma membranes from rat hippocampus. New Orleans, U.S.A (2000)

(106)*161) 29th Annual Meting of Society for Neurosciences.

Gorini, A., D’Angelo, A., Devecchi, E., Villa, R.F. Glutamate metabolism of cerebral cortex mitochondria during ageing in normotensive or hypertensive rats. New Orleans, U.S.A. (2000)

(107)*162) 45° Congresso Nazionale della Società Italiana di Gerontologia e Geriatria. Gorini, A., D’Angelo, A., Devecchi, E., Villa, R.F. Ipossia cerebrale e ATP-asi sinaptiche. Firenze (2000)

163) Second Conference of the International Coenzyme Q Association. Biochemical heterogeneity of brain mitochondria. Frankfurt, Germania (2000)

164) Colloquia of the National Academy of Sciences: "Neuronal Signaling". Neuronal signaling during hypoxia and pharmacological treatment.

Washington D.C. U.S.A. (2001) (108)*165) 5th International Conference "Progress in Alzheimer's and Parkinson's Diseases".

Villa, R.F., Devecchi, E., Gorini, A. Mitochondrial factors in Parkinson's Disease by MPTP toxicity in Macaca fascicularis cerebral cortex. Kyoto, Giappone (2001)

(109)*166) 5th International Conference "Progress in Alzheimer's and Parkinson's Diseases". Devecchi, E., D’Agostino, F., De Giuli, A., D’Agostino, M., Cambiè, G., Gorini, A., Villa, R.F. Frequency of Apolipoproteine-E alleles in patients with diagnosis of Dementia. Kyoto, Giappone (2001)

(110)*167) XXX Congresso Nazionale della Società Italiana di Farmacologia. Gorini, A., Devecchi, E., Villa, R.F. Effetto della clonidina sull'attività ATP-asica delle membrane sinaptiche della corteccia cerebrale. Genova (2001)

(111)*168) XXXII Congresso Nazionale della Società Italiana di Neurologia. Villa, R.F., Devecchi, E., Gorini, A. Effect of clonidine administration on some ATP-ases enzyme activities of synaptic plasma membranes from brain. Rimini (2001)

(112)*169) 31th Annual Meting of Society for Neurosciences. Gorini, A., Borghi, E., Devecchi, E., Villa, R.F. Cerebral cortex during ageing: synaptic mitochondrial metabolism of normotensive or hypertensive rats. San Diego, U.S.A. (2001)

(113)*170) 31th Annual Meting of Society for Neurosciences. Villa, R.F., Borghi, E., Devecchi, E., Gorini, A. ATP-ases activities during aging of synaptic plasma membranes from striatum. San Diego, U.S.A. (2001)

(114) *171) Third World Congress on “Vascular Factors in Alzheimer’s Disease”. Devecchi, E., De Giuli, A., D’Agostino, F., Cambiè, G., D’Agostino, M.,Faggi, L., Colturani, G., Gorini, A., Villa, R.F: A study on the possible association between Apo-E alleles and Dementia. Kyoto, Giappone (2002).

(115)*172) XIVth World Congress of Pharmacology Villa, R.F., Devecchi, E., Gorini, A. ATP-ases activities of synaptic plasma membranes after clonidine treatment. San Francisco, U.S.A (2002).

(116)*173) 47° Congresso nazionale della Società italiana di Biochimica Gorini, A., Devecchi, E., Villa, R.F.

Somatic and synaptic plasma membranes from hippocampus: ATP-ases’ activities during ageing. Palermo, (2002).

(117)*174) International Conference on “The Structural Bsis of Understanding Human Brain Function and Dysfunction” Villa, R.F., Gorini, A. Regional mitochondrial energy metabolism of cerebral tissue during ageing. Roma, (2002).

(118)*175) 32nd Annual Meeting of Society for Neurosciences. Villa, R.F., Devecchi, E., Gorini, A. ATP-ases activities of type 1 and type 2 synaptic plasma membranes from rat striatum amd clonidine teatment. Orlando, U.S.A (2002).

(119)*176) 32nd Annual Meeting of Society for Neurosciences. Gorini, A., Devecchi, E., Villa, R.F. Mitochondrial metabolism of normotensive and hypertensive rat cerebral cortex during ageing. Orlando, U.S.A (2002).

(120)*177) 2002 First World Congress of “The Human Proteome Organisation”. Villa, R.F., Gorini, A.

Isoenzyme forms and catalytic activity of brain Na+-K+-ATP-ase during ageing. Versailles, France (2002).

(121)*178) Congresso Nazionale Sezione Italiana della “The Human Proteome Organisation”. Villa, R.F., Gorini, A. ATP-ases of synaptic plasma membranes and synaptic vesicles during ageing and experimental hypoxia. Napoli, (2003).

(122)*179) 75th Annual Scientific Meeting of the “Aerospace Medical Association”. Villa, R.F., Gorini, A. Effect of microgravity and environmental stress on brain energy metabolism and function. Anchorage, Alaska, U.S.A.. (2004).

(123)*180) XIV Congresso Nazionale della Società Italiana di Neuropsicofarmacologia. Villa, R.F., Gorini, A., Brera, F, Carra, S., Tascedda, F., Brunello, N. Effect of some antidepressants on mitochondrial metabolism of rat cerebral cortex. Bologna, (2004).

(124)*181) 20th International Conference of Alzheimer’s Disease International Kyoto 2004. Devecchi, E., De Giuli, A., D’Agostino, F., Cambiè, G., D’Agostino, M.,Faggi, L., Colturani, G., Gorini, A., Brera, F., Villa, R.F. Mitochondrial energy.linked enzymes in lymphocytes of patients with dementia Kyoto, Giappone. (2004).

182) 33rd Annual Meeting of the American College of Clinical Pharmacology. Mitochondrial Energy-Linked Enzymes in Lymphocytes During Ageing as Biochemical Markers for Drug’s Action Phoenix, U.S.A. (2004).

(125)*183) 34th Annual Meeting of Society for Neurosciences. Villa, R.F., Devecchi, E., De Giuli, A., D’Agostino, F., Cambiè, G., D’Agostino, M.,Faggi, L., Colturani, G., Brera, F., Gorini, A. Mitochondrial and cytoplasmic enzymes of lymphocytes from patients with a diagnosis of dementia. San Diego, U.S.A. (2004).

(126)*184) 34th Annual Meeting of Society for Neurosciences. Geroldi, D., D’Angelo, A., Gorini, A., Villa, R.F., Peros, E., Montagna, L., Minoretti, P., Emanuele, E.

The apolipoprotein(a) size polymorphism is associated with Alzheimer’s disease and vascular dementia. San Diego, U.S.A. (2004).

127)*185) Habitation Conference - NASA. Villa, R.F., Gorini, A. Effect of microgravity and environmental stress on brain energy metabolism and function: Human Life Support. Orlando, U.S.A. (2004).

(128)*186) 34th Annual Meeting of the American College of Clinical Pharmacology. Villa, R.F., Devecchi, E., Brera, F., De Giuli, A., D’Agostino, F., D’Agostino, M., Cambiè, G., Faggi, L., Colturani, G., Gorini, A. Energy linked enzymes in lymphocytes of patients with a diagnosis of dementia. Rockville Pike - Bethesda, U.S.A. (2005).

(129)*187) 36à Congresso Nazionale della Società Italiana di Neurologia. Villa, R.F., Devecchi, E., D’Agostino, F., D’Agostino, M., Geroldi, D., Emanuele, E., Brera, F., Gorini, A. Functional proteomics of energy-linked enzymes in lymphocytes is related to metabolic failure in acute stroke patients. Cernobbio, (2005).

(130)*188) 35th Annual Meeting of Society for Neurosciences. Villa, R.F., Brera, F., Gorini, A., Devecchi, E., De Giuli, A., D’Agostino, F., D’Agostino, M., Cambiè. Mitochondrial metabolism of lymphocytes during ageing. Washington, U.S.A. (2005).

(131)*189) 15th World Congress of Pharmacology (IUPHAR). Villa, R.F., Gorini, A., Brera, F., Geroldi, D. Functional proteomics of lymphocytes is related to energy failure in acute stroke. Beijing (Pechino), Cina (2006).

(132)*190) 23rd International Symposium on Cerebral Blood Flow, Metabolism & Function and 8th International Conference on Quantification of Brain Function with PET. Villa, R.F., Gorini, A., Geroldi, D., Pero, G., Brera, F. Energy metabolism of lymphocytes from acute stroke patients. Osaka, Giappone (2007).

(133)*191) XXXIII Congresso Nazionale della Società Italiana di Farmacologia. Brera, F., Gorini, A., Villa, R.F. Mitochondrial factors involved in Parkinson’s disease by MPTP toxicity in Macaca Fascicularis and drug effect. Cagliari (2007).

192) Conferenza su “Industria del Farmaco e Società Medico Scientifiche”. Circolo della Stampa di Milano. Milano, (2008).

193) 6th Giornata di Studio sulle Cellule Staminali. Terapia Genica e Cellule Staminali. Milano (2009).

(134)*194) XXXIV Congresso Nazionale della Società Italiana di Farmacologia. Villa, R.F., Devecchi, E., Brera, F., Pero, G., Gorini, A. Metabolomics of energy-linked enzymes in lymphocytes from acute stroke patients Rimini (2009).

195) 9th Giornata di Studio sulle Cellule Staminali. Staminali e geni nello sviluppo del cervello. Milano (2010).

(135)*196) 35th Annual Meeting of Society for Neurosciences. Villa, R.F., Ferrari, F., Gorini, A. Action of some antidepressants on mitochondrial energy metabolism of rat cerebral cortex.

Washington, U.S.A. (2011). (136)*197) Nuove Strategie Terapeutiche nell’Ischemia Cerebrale

Villa, R.F., Ferrari, F., Gorini, A., Hoyer, S. Effect of cerebral ischemia and postischemic recovery during aging on mitochondrial energy metabolism: an in vivo model for experimental therapy. Urbino, (2012).

(137)*198) 16° Seminario SIF Dottorandi e Assegnisti di Ricerca Ferrari, F., Gorini, A., Hoyer, S., Villa, R.F. Cerebral ischemia and postischemic recovery during aging: metabolomics of Krebs’ cycle , glutamate and related amino acids enzyme activities as a functional approach for responsiveness of ischemic tissue. Rimini, (2012).

(138)*199) International Congress on “Brain Ischemia and Stroke” Villa, R.F., Ferrari, F., Gorini, A., Hoyer, S. Aging and cerebral ischemia during postischemic recovery: enzyme activities of Krebs’ cycle, glutamate and related amino acids as a functional proteomics approach to evaluate the responsiveness of ischemic tissue and drug actions Roma, (2012).

(139)*200) XVII Conferenza Nazionale sull’Ictus Cerebrale – Stroke 2013 Villa, R.F., Geroldi, D., Ferrari, F., Gorini, A. Functional proteomics of energy-linked enzymes in lymphocytes after stroke. Firenze, (2013).

201) Convegno Monotematico Nazionale della Società Italiana di Farmacologia. Alzheimer Disease: which are the challenges we need to face. Milano (2013).

(140)*202) Convegno Monotematico Nazionale della Società Italiana di Farmacologia. Inflammatory based diseases: molecular and cellular mechanisms Villa, R.F., Geroldi, D., Devecchi, E., Ferrari, F., Gorini, A. Peripheral energy dysfunction in cerebral ischemia: focus on lymphocytes. Napoli, (2013).

(141)*203) Congresso Internazionale della Società Italiana di Neuroscienze. Cerebral ischemia and peripheral energy dysfunction in lymphocytes Villa, R.F., Geroldi, D., Devecchi, E., Ferrari, F., Pero, G., Gorini, A.

Roma, (2013). (142)*204) Congresso Nazionale della Società Italiana di Farmacologia.

Effect of in vivo administration of L-acetylcarnitine on ATP-ases of synaptic plasma membranes of rat striatum. Ferrari, F., Gorini, A., Villa, R.F.. Torino, (2013).

(143)*205) Congresso “Dagli Atomi al Cervello”, Politecnico di Milano “Progetto Brain” Functional Proteomics and Metabolomics of Brain Energy Metabolism in Pathology and Therapy Villa R. F., Ferrari F., Gorini A. Milano, (2014).

(144)*206) I Congresso Nazionale Ictus Cerebrale della Italian Stroke Organization. Functional proteomics of energy-linked enzymes in lymphocytes after stroke: an update Villa R.F., Geroldi D., Devecchi E., Ferrari F., Gorini A. Firenze, (2014).

207) Convegno Monotematico Nazionale della Società Italiana di Farmacologia. Mood Disorders: from Neurobiology to Novel Therapeutic Strategies Modena (2014).

(145)*208) International Congress .

Energy metabolism of mitochondria after ischemia and recovery times during aging and peripheral energy dysfunction in stroke patients: focus on lymphocytes. Villa, R.F., Geroldi, D., Devecchi, E., Ferrari, F., Pero, G., Gorini, A.

Magdeburg, Germany, (2014). 209) 16th Giornata di Studio sulle Cellule Staminali.

La complessità delle malattie neurologiche: quale spazio per le staminali? Milano (2014).

(146)*210) 37th Annual Meeting of Society for Neurosciences.. Lymphocytes bioenergetics after stroke: a functional proteomic study Ferrari, F., Geroldi, D., Gorini, A., Pero, G., Villa, R.F..

Washington, USA, (2014). (147)*211) 17° Seminario SIF Dottorandi e Assegnisti di Ricerca

L-acetylcarnitine and ATP-ases of synaptic plasma membranes of rat hippocampus: implications for Alzheimer’s Disease and Dementia Therapy. Ferrari, F., Gorini, A., Villa, R.F. Rimini, (2014).

212) International Congress on Bioeconomy e Ricevimento al Quirinale Neurodegenerative Diseases. Roma (2014).

(148)*213) International Congress on Cerebral Ischemia . Functional proteomics of mitochondria in aging and cerebral ischemia during postischemic recovery: enzyme activities of electron transfer chain complex of non-synaptic and intra-synaptic mitochondria. Ferrari, F., Gorini, A., Hoyer, S., Villa R.F.. Roma (2014).

214) Simposio della Società Italiana di Farmacologia. Globalizazione e Ricerca Clinica per lo sviluppo dei farmaci Università degli Studi di Milano Milano, (2014).

(149)*215) II Congresso Nazionale Ictus Cerebrale della Italian Stroke Organization. Glutamate metabolism in aging and experimental stroke Villa R.F., Gorini A., Ferrari F., Hoyer S. Firenze, (2015)

216) 13 Giornata di Studio sulla malattia di Alzheimer. Psicologia e Funzioni Cognitive Ateneo Veneto, Aula Magna Venezia, (2015)

(150)*217) 24th European Stroke Conference Mitochondrial energy metabolism of brain and lymphocytes after ischemia and recovery during aging. Ferrari, F., Geroldi D., Gorini A., Pero G., Hoyer S., Villa R.F.. Vienna, Austria (2015)

218) Convegno Alma Laurea. Università Bicocca. Milano (2015).

219) 5° Convegno Nazionale sulle Malattie Mitocondriali. Associazione Mitocon ONLUS. Bologna, (2015)

(151)*220) 45th Annual Meeting of Society for Neuroscience, U.S.A. Bioenergetics of desipramine: a functional proteomics. Study. Ferrari F., Gorini A., Villa R.F.. Chicago, U.S.A. (2015)

(152)*221) 37° Congresso Nazionale della Società di Farmacologia. Bioenergetic effects of Clonidine on functional proteomics.

Ferrari F., Gorini A., Villa R.F.. Napoli, (2015)

222) 3° Congresso Nazionale sull’Ictus cerebrale, Stroke 2016. Effetto della somministrazione acuta di clonidina sul metabolismo energetico cerebrale. Ferrari, F., Gorini, A., Pero, G., Villa, R.F.. Firenze, (2016)

223) Convegno Monotematico Internazionale della Società di Farmacologia “The stressed brain: psychopathologic implications and pharmacological intervention”. Effect of aging on the energy metabolism of cerebral cortex, hypothalamus and hypophysis: implications for the responsiveness to stress. Ferrari F., Gorini A., Villa R.F..

Milano, (2016) (153)*224) 25th European Stroke Conference

Bioenergetic characterization of lymphocytes from stroke patients. Ferrari, F., Devecchi, E., Pero G., Gorini A., Villa R.F.. Venezia, (2016)

(154)*225) 18° Seminario SIF Dottorandi e Assegnisti di Ricerca The energy metabolism of cerebral mitochondria of hypertensive rats to study the action of drugs on this major risk factor for the prevention of ischemic stroke Ferrari, F., Gorini, A., Villa, R.F. Rimini, (2016).

(155)*226) 45th Annual Meeting of Society for Neuroscience U.S.A. Bioenergetics of Fluoxetine: a functional proteomic study. Ferrari, F., Gorini, A., Villa, R.F. San Diego, U.S.A., (2016)

227) Convegno: Attività Preclinica e Clinica: il Ruolo della Farmacologia Roma, (2016).

(156)*228) More than neurons: towards a less neuronocentric view of brain disorders Bioenergetics of lymphocytes as biomarkers of ischemic stroke patients during aging. Ferrari, F., Bagini, L., Devecchi, E., Pero, G., Gorini, A., Villa, R.F. Torino (2016).

(157)*229) BIS 16 – Brain, Ischemia and Stroke 2016 Characterization of lymphocyte bioenergetics as potential biomarker in ischemic stroke patients during aging. Ferrari, F., Bagini, L., Devecchi, E., Pero, G., Gorini, A., Villa, R.F. Roma (2016).

(158)*230) IV Congresso Nazionale dell’Italian Stroke Organization (I.S.O.) Effetti degli antiipertensivi sulla prevenzione dell’Ictus ischemico acuto e interazioni con la terapia trombolitica. Ferrari, F., Bascì, J., Bagini, L., Viscardi, P., Pero, G., Moretti, A., Villa, R.F. Napoli (2017).

231) Convegno Alma Laurea. Università di Parma. Parma (2017).

232) Convegno: Modelli Sperimentali per lo Studio della Ischemia Cerebrale. Consiglio Nazionale delle Ricerche (CNR). Roma (2017).

(159)*233) 26th European Stroke Conference Prevention of acute and recurrent stroke by anti-hypertensives and interaction with thrombolysis Ferrari, F., Basci’, J., Bagini, L., Viscardi, P., Pero, G., Moretti, A., Villa, R.F. Berlin, Germany (2017)

(160)*234) 47th Annual Meeting of Society for Neuroscience U.S.A. Prevention of acute and recurrent stroke with statins and interaction with thrombolysis. Ferrari, F., Bagini, L., Moretti, A., Villa, R.F. Washington, U.S.A., (2017)

(161)*235) 38° Congresso Nazionale della Società di Farmacologia Effects of Clonidine on hippocampal synaptic energy metabolism: a functional proteomic study. F. Ferrari, J. Bascì, L. Bagini, P. Viscardi, A. Viotti, A. Gorini, R.F. Villa. Rimini (2017).

(162) *236) XXVII Congresso Nazionale della Società Italiana di Neuroscienze Ferrari, F., Devecchi, E., Pero G., Villa, R.F. Lymphocyte bioenergetics in ischemic stroke patients during aging.

Napoli, (2017) (163)*237) XXVII Congresso Nazionale della Società Italiana di Neuroscienze

Ferrari, F., Devecchi, E., Pero G., Villa, R.F. Lymphocyte bioenergetics in ischemic stroke patients during aging. Ischia, 2017

238) V Congresso Nazionale della Italian Stroke Organization Roma, (2018)

(164) *239) 27 European Stroke Conference 2018 Physiopathological Mechanisms and Pharmacological treatment of post-stroke depression. F. Ferrari, J. Bagini, G. Pero, A. Moretti, R.F. Villa. Athens, Grecia (2018).

(165) *240) 48th Annual Meeting of Society for Neuroscience U.S.A. Ferrari, F., Bagini, L., Gorini, A., Villa, R.F. Selective effects on energy-utilizing ATPases of synapses derived from hippocampal sub-fields. San Diego, U.S.A. (2018)

(166) *241) 48th Annual Meeting of American College of Clinical Pharmacology, U.S.A. Emerging Therapies for Hyperglycemia in Acute Ischemic Stroke: Glucagon-like Peptide 1 Receptor Agonists and Dipeptidyl Peptidase IV Inhibitors Ferrari F.*, Moretti A., Villa R.F. Chicago, U.S.A. (2019)

(167) *242) 39° Congresso Nazionale della Società di Farmacologia Ferrari, F., Tascedda, A., Brunello, N., Villa, R.F. Antidepressants and cerebral energy metabolism: new functional proteomic insights. Firenze, (2019)

243) Conferenza Internazionale Accademia dei Lincei International Antonio Feltrinelli Conference Ageing: from Basic Science to Policy Advice. Roma, (2019)

(168) *244) 39° Congresso Nazionale della Società di Farmacologia Ferrari, F., Tascedda, A., Brunello, N., Villa, R.F. Antidepressants and cerebral energy metabolism: new functional proteomic insights. Firenze, (2019)

Aggiornato al 1 Ottobre 2019.