Prof.ssa Marcella Reale Università "G. d'Annunzio" di Chieti - Pescara Dip. Scienze Sperimentali e Cliniche, Sez. Immunodiagnostica e Patologia Molecolare Nuovo Polo Didattico, Ed. C, III Livello, Via dei Vestini, 31 66100 Chieti Tel. 0871 3554029, E-mail. mreale@unich.it

Dati personali:

Nata a Montorio Al Vomano (TE) il 30/1/1957. 1981 Laurea in Scienze Biologiche, Alma Mater Studiorum, Università di Bologna 1988 Dottorato di Ricerca in Medicina Sperimentale, Università “La Sapienza”, Roma.

Posizione attuale Professore associato 06/A2 Patologia generale (MED/04), Facoltà di Medicina, Università “G. D'Annunzio” Chieti-Pescara

Attività di ricerca: Studio della risposta infiammatoria nelle patologie neurodegenerative e autoimmuni. Utilizzo di modelli animali e modelli in vitro, per definire le basi molecolari di tali patologie. Lo studio degli effetti dei campi elettromagnetici a bassa frequenza su modelli cellulari finalizzati a sostenere e supportare il loro uso terapeutico. Approcci sperimentali: Culture cellulari, proliferazione e migrazione cellulare, produzione di citochine e specie reattive dell'ossigeno. Saggi enzimatici, Western blotting, RT-PCR.

Attività Editoriale Reviewer per: Acta Biomaterialia Acta Neuropsychiatrica AGE Annual Review & Research in Biology Cytokine Cochrane Dementia and Cognitive Improvement Review Group Current Alzheimer Research European Cytokines Network Journal of Neuroimmunology Journal of Pharmacy and Pharmacology Journal of Psychiatric Research Mediators of inflammation Neuroscience Letters Neurochemical Research Neuroimmunomodulation Psychiatric Research Plos Preparative Biochemistry and Biotechnology

Guest editor:

Journal Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry (AIAAMC)

Associate Editor: Journal of Alzheimer’s Disease (JAD) International Journal of Alzheimer’s Disease (IJAD) Int J Clin Exp Med ISRN Inflammation American Journal of Neurodegenerative Disease (AJND)

PROJECTS REVIEWER 2009 Cochrane Dementia and Cognitive Improvement” Review Group 2010 Reviewing Committee for Research Grant "JOINT PROJECTS 2010” 2011 Reviewer for French National Research Agency (ANR) "SAMENTA 2011" 2013 Reviewer for National Agency for Evaluation of Universities and Research Institute (ANVUR)

COLLABORAZIONI DI RICERCA NAZIONALI E INTERNAZIONALI:

Prof.ssa Ada Maria Tata, Department of Biology and Biotecnologies Charles Darwin Sapienza, University of Rome, Italy Prof. Mohammad A. Kamal, (PhD, FRACI C Chem), King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia Prof. Nigel H. Greig, Laboratory of Neurosciences, National Institute on Aging, Baltimore, MD 21224-6825, USA Prof.ssa Laura López-Mascaraque, Molecular, Cellular and Developmental Neurobiology, Instituto Cajal-CSIC, Madrid, Spain

Attività didattica:

Corso di Laurea in Medicina e Chirurgia: Fisiopatologia e Patologia Generale e Immunologia. Corso di Laurea Tecniche di Laboratorio Biomedico: Patologia e Immunologia Corso di Laurea Tecniche della Prevenzione dell'Ambiente e Luoghi di Lavoro: Patologia Generale Coordinatore del corso integrato di Fisiologia umana e Patologia generale e Immunologia del C.d.L. in Tecniche di Laboratorio Biomedico Coordinatore del corso integrato di Fisopatologia e Microbiologia del C.d.L. in Tecniche della Prevenzione dell’Ambiente e Luoghi di Lavoro,

ELENCO PUBBLICAZIONI ULTIMI 5 ANNI

1. C. Iarlori, D. Gambi, A. Lugaresi, A. Patruno, M. Felaco, M. Salvatore, L. Speranza, M. Reale. Reduction of free radicals in Multiple Sclerosis: effect of glatiramer acetate (Copaxone®) Multiple Sclerosis Journal 2008,14:739-748

2. G. Vianale, M. Reale, P. Amerio, M. Stefanachi, S. Di Luzio, and R. Muraro. Extremely Low Frequency Electromagnetic Field (ELF-EMF) enhances human keratinocyte cell growth and decreases pro-inflammatory chemokines production. British Journal of Dermatology 2008; 158(6):1189-1196.

3. M. Reale, C.Iarlori, C. Feliciani, D.Gambi. Peripheral chemokine receptors, their

ligands, cytokines and Alzheimer's disease. Journal of Alzheimer’s Disease, 2008; 14 (2): 147-159

4. Boscolo P, Di Donato A, Di Giampaolo L, Forcella L, Reale M, Dadorante V, Alparone

F, Pagliaro S, Kouri M, Magrini A, Fattorini E. Blood natural killer activity is reduced in men with occupational stress and job insecurity working in a university. Int Arch Occup Environ Health. 2009, 82(6):787-94.

5. M. Reale, C Iarlori, A Thomas, D Gambi, B Perfetti, M. Di Nicola, M Onofrj. Peripheral cytokines profile in Parkinson’s Disease. Brain, Behavior and Immunity 2009 Jan; 23(1):55-63.

6. Maccallini C, Patruno A, Besker N, Alì JI, Ammazzalorso A, De Filippis B,

Franceschelli S, Giampietro L, Pesce M, Reale M, Tricca ML, Re N, Felaco M, Amoroso R. Synthesis, biological evaluation and docking studies of N-substituted acetamidines as selective inhibitors of inducible nitric oxide synthase J Med Chem. 2009. Mar 12;52(5):1481-5.

7. Kamal MA, Greig NH, Reale M. Anti-Inflammatory Properties of Acetylcholinesterase

Inhibitors Administred in Alzheimers Disease Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 2009, 8, 1, 85-100.

8. Reale M., Greig N.H., Kamal M.A. Peripheral chemo-cytoines profiles in alzheimer’s

and Parkinson’s disease. Mini-Reviews in Medicinal Chemistry 2009 Sep;9(10):1229-41.

9. Patruno A, Amerio P, Pesce M, Vianale G, Di Luzio S, Tulli A, Franceschelli S, Grilli

A, Muraro R, Reale M. Extremely low frequency electromagnetic field (elf-emf) modulate iNOS, eNOS and Cox-2 expressions in the human keratinocyte cell line hacat: potential therapeutical effects in wound healing. British Journal of Dermatology 2010 162, pp258–266

10. Amerio P, Vianale G, Reale M, Trubiani O, Muraro R, Tulli A, Piattelli A. The effect

of deproteinized bovine bone on osteoblast growth factors and pro-inflammatory cytokine production. Clinical Oral Implants Research 21, 2010 (6):650-5.; 650–655.ISSN 0905-7161

11. Kamal MA, Reale M, Al-Jafari AA. Multiple Approaches to Analyse the Data for Rat Brain Acetylcholinesterase Inhibition by Cyclophosphamide. Neurochem Res. 2010. 35(10):1501-9.

12. Speranza L, Franceschelli S, Pesce M, Reale M, Menghini L, Vinciguerra I, De Lutiis MA, Felaco M, Grilli A. Antiinflammatory effects in THP-1 cells treated with verbascoside. Phytother Res. 2010;24(9):1398-404.

13. Reale M, Patruno A, De Lutiis MA, Pesce M, Felaco M, Di Giannantonio M, Di Nicola M, Grilli A.Dysregulation of chemo-cytokine production in schizophrenic patients versus healthy controls. BMC Neurosci. 2011 Jan 25;12(1):13.

14. Patruno A, Pesce M, Marrone A, Speranza L, Grilli A, De Lutiis MA, Felaco M, Reale M.Activity of matrix metallo proteinases (MMPs) and the tissue inhibitor of MMP (TIMP)-1 in electromagnetic field-exposed THP-1 cells. J Cell Physiol. 2011 Sep 16. doi: 10.1002/jcp.23024 .

15. Reale M, Vianale G, Lotti LV, Mariani-Costantini R, Perconti S, Cristaudo A, Leopold K, Antonucci A, Di Giampaolo L, Iavicoli I, Di Gioacchino M, Boscolo P. Effects of palladium nanoparticles on the cytokine release from peripheral blood mononuclear cells of palladium-sensitized women. J Occup Environ Med. 2011 Sep;53(9):1054-60. doi: 10.1097/JOM.0b013e318228115e. .

16. Reale M, Boscolo P, Bellante V, Tarantelli C, Di Nicola M, Forcella L, Li Q, Morimoto K, Muraro R. Daily intake of Lactobacillus casei Shirota increases natural killer cell activity in smokers. Br J Nutr. 2011 Dec 6:1-7 .

17. Patruno A, Tabrez S, Amerio P, Pesce M, Vianale G, Franceschelli S, Grilli A, Kamal MA, Reale M. Kinetic Study on the Effects of Extremely Low Frequency Electromagnetic Field on Catalase, Cytochrome P450, Inducible Nitric Oxide Synthase in Human HaCaT and THP-1 Cell Lines. CNS Neurol Disord Drug Targets. 2011 Dec 1;10(8):936-44.

18. Al Jafari AA, Shakil S, Reale M, Kamal MA. Human Platelet Acetylcholinesterase Inhibition by Cyclophosphamide: A Combined Experimental and Computational Approach. CNS Neurol Disord Drug Targets. 2011 Dec 1;10(8):936-44.

19. Reale M, Kamal MA, Velluto L, Gambi D, Di Nicola M, Greig NH. Relationship between Inflammatory Mediators, Aβ Levels and APOE Genotype in Alzheimer's Disease. Curr Alzheimer Res. May;9(4):447-57, 2012

20. Reale M, Pesce M, Priyadarshini M, Kamal MA, Patruno A. Mitochondria as an Easy Target to Oxidative Stress Events in Parkinson's Disease. CNS Neurol Disord Drug Targets Jun 1;11(4):430-8. 2012,

21. Priyadarshini M, Kamal MA, Greig NH, Reale M, Abuzenadah AM, Chaudhary A, Damanhouri GA. Alzheimers Disease and Type 2 Diabetes: Exploring the Association to Obesity and Tyrosine Hydroxylase. CNS Neurol Disord Drug Targets. Jun 1;11(4):482-9 2012 May 11.

22. Reale M., De Angelis F. , Di Nicola M. , Capello E. , Di Ioia M. , De Luca G. , Lugaresi A., Tata A.M. Relation between Pro-inflammatory Cytokines and Acetylcholine Levels in Relapsing-Remitting Multiple Sclerosis Patients. Int. J. Mol. Sci. 2012, 13(10), 12656-12664; doi:10.3390/ijms131012656

23. Yu QS, Reale M, Kamal MA, Holloway HW, Luo W, Sambamurti K, Ray B, Lahiri DK, Rogers JT, Greig NH. Synthesis of the Alzheimer drug Posiphen into its primary metabolic products (+)-N1-norPosiphen, (+)-N8-norPosiphen and (+)-N1, N8-bisnorPosiphen, their inhibition of amyloid precursor protein, α-synuclein synthesis, interleukin-1β release, and cholinergic action. Antiinflamm Antiallergy Agents Med Chem. 12, 2: 117 – 128, 2013

24. Reale M, Tata AM.Modulation of Cholinergic System Activity in Neuronal and Non-Neuronal Tissues: Therapeutic Implications. Antiinflamm Antiallergy Agents Med Chem. 12, 2: 108, 2013

25. Greig NH, Reale M, Tata AM. New Pharmacological Approaches to the Cholinergic System: An Overview on Muscarinic Receptor Ligands and Cholinesterase Inhibitors. Recent Pat CNS Drug Discov. 2013, 8, 2: 123 – 141.

26. Auriemma M, Vianale G, Amerio P, Reale M.Cytokines and T cells in atopic dermatitis. Eur Cytokine Netw. 2013 Mar 1;24(1):37-44.

27. Pesce M, Patruno A, Speranza L, Reale M. Extremely low frequency electromagnetic field and wound healing: implication of cytokines as biological mediators. Eur Cytokine Netw. 2013 Mar 1;24(1):1-10.

28. Kamal MA, Shahida K, Gan SW, Firoz CK, Khan A, Abuzenadah A, Kamal W, Aliev G,

Reale M. Alzheimer's Disease and Type 2 Diabetes Mellitus: The Link to Tyrosine Hydroxylase and Probable Nutritional Strategies. CNS Neurol Disord Drug Targets. (In press) 2013.

29. BOOK

1. Marcella Reale, Carla Iarlori, Claudio Feliciani, Domenico Gambi. Chemokine Involvement in Alzheimer's Disease Pathogenesis: Implication for Peripheral Inflammatory Process. Progress in Chemokine Research, Ed. W.P. Linker, Chap.12.. ISBN 978-1-60021-641-1. Nova Science Publisher,Inc. 2007

2. Lucia Velluto, Carla Iarlori, Domenico Gambi, Marcella Reale CYTOKINES AND ALZHEIMER’S DISEASE. Cytokines: Preedy, Victor R.; Hunter, Ross. Taylor & Francis Inc. ISBN: 9781578086900 June 2011

3. Carla Iarlori, Domenico Gambi, Marcella Reale PARKINSON’S DISEASE AND CYTOKINES. Cytokines: Preedy, Victor R.; Hunter, Ross. Taylor & Francis Inc. ISBN: 9781578086900 June 2011

4. Reale M. Cytokine network as attractive therapeutic target for neurodegenerative diseases. In "Cytokines: Mechanisms, Functions and Abnormalities " Chapter 4. E-Book, NOVA SCIENCE PUBLISHERS, INC (2012) ISBN: 978-1-62100-975-7

5. G. Vianale, M. Auriemma, P. Amerio and M. Reale. Keratinocytes and Anti Microbial Peptides: Influence of Extremely Low Frequency Electromagnetic Field (ELF-EMF). Chapter 7. Cell Biology Research Progress Dermatology - Laboratory and Clinical Research, Nova Science Publisher ebook. 2013 - 4th Quarter. ISBN 978-1-62618-920-1

6. Reale M, Amerio P. Extremely Low Frequency Electromagnetic Field and Cytokines Production. In “Electromagnetic Fields: Principles, Engineering Applications and Biophysical Effects”. Chapter 6. (pp. 239-254) Nova Science Publisher. 2013. Editors: Myung-Hee Kwang and Sang-Ook Yoon. ISBN 978-1-62417-063-8

ELENCO PUBBLICAZIONI 1. P. Conti, M.G. Cifone, E. Alesse, G. Ianni, M. Reale and P.U. Angeletti: Effects of

salicylates on lymphocyte blastogenesis in vitro: association with other non steroid anti-inflammatory drugs. Clin. Rheumatol. 1983; 2, 127-132.

2. Conti P, Gigante GE, Cifone MG, Alesse E, Ianni G, Reale M, Angeletti PU. Reduced

mitogenic stimulation of human lymphocytes by extremely low frequency electromagnetic fields. FEBS Lett. 1983, 3;162(1):156-160.

3. P. Conti, M.G. Cifone, E. Alesse, G. Ianni, M. Reale and P.U. Angeletti: A comparative

study of the effects of some non-steroidal antiinflammatory drugs on prostacyclin production ex-vivo and thromboxane B2 release by polymorphonuclears in vitro. Agents and Actions, 1984;15, (1-2), 91.

4. Conti P, Gigante GE, Alesse E, Cifone MG, Fieschi C, Reale M, Angeletti PU. A role

for Ca2+ in the effect of very low frequency electromagnetic field on the blastogenesis of human lymphocytes. FEBS Lett. 1985;11;181(1):28-32.

5. Conti P, Cifone MG, Alesse E, Reale M, Boidi E, Williams T. Effect of supernatants

from PHA-stimulated and non-stimulated lymphocyte cultures on thromboxane B2 release by polymorphonuclear leukocytes in vitro. Agents Actions. 1985;16(1-2):52-54.

6. Conti P, Allegretta M, Williams TW, Cifone MG, Alesse E, Reale M, Boidi E, Dempsey RA. Enhanced thromboxane synthesis and vacuolization in human polymorphonuclear leucocytes induced by human lymphokine containing supernatants. Clin Rheumatol. 1985;4(4):410-419.

7. Conti P, Cifone MG, Alesse E, Reale M, Fieschi C, Dinarello CA. In vitro enhanced thromboxane B2 release by polymorphonuclear leukocytes and macrophages after treatment with human recombinant interleukin 1. Prostaglandins. 1986 ;32(1):111-115.

8. P. Conti, M.G. Cifone, E. Alesse, M. Reale, C. Fieschi, S. Fiore, M. Bologna and C.A. Dinarello: Synergistic sctivation of natural killer activity by human recombinant Interferon alpha or gamma and indomethacin. Int. J. Immunother. 1986; 4, 289-293.

9. M.G. Cifone, E. Alesse, M. Reale, M. Bologna, P.U. Angeletti and P. Conti.

Stimulatory effect of hrTNF on TxB2 release by polymorphonuclears and macrophages. Agents and Actions, 1986; 19, 5/6, 349-350.

10. M.G. Cifone, E. Alesse, M. Reale, C. Fieschi, M. Bologna, S. Fiore and P. Conti: Effect of hrTNF alpha on TxB2 release by macrophages. Int. J. Tissue Reac., 1987; 9, 51-53.

11. P.Conti, M. Reale, A. Cancelli, P.U. Angeletti. Lipoxin A augments release of thromboxane from human polymorphonuclear leukocyte suspensions. FEBS lett, 1987; 225,1-2:103-108.

12. P. Conti, M. Reale, R.C. Barbacane, M. Bongrazio, M.R. Panara and S. Fiore: Cytokines and arachidonic acid metabolites: Int. J. Immunopathol. Pharmacol., 1989; 2, 95-98.

13. P.Conti, M. Reale, S. Fiore, R.C. Barbacane, M. Bongrazio,M.R. Panara, L. Carratelli.

Enhanced natural killer cell activity by proglumetacin, a non-steroidal anti-inflammatory drug. Agents and Actions, 1989; 26,1-2:216-218.

14. P. Conti, M. Reale, R.C. Barbacane, M. Bongrazio and M.R. Panara: Lipoxin A4 and

B4 inhibit leukotriene B4 generation from human neutrophil leukocyte suspensions. Immunol.Letters, 1990; 24, 237-242 .

15. P. Conti, M. Reale, R.C. Barbacane, M. Bongrazio, M.R. Panara, S. Fiore, R. Dempsey

and L. Borish. Leukocyte inhibitory factor activates human neutrophils and macrophages to release leukotriene B4 and thromboxanes. Cytokine, 1990; 2, 142-148

16. P. Conti, M. Reale, P. Trisi, R.C. Barbacane, M.R. Panara, M. Bongrazio and A. Piattelli: Lipoxins increase granuloma formation induced by potassium permanganate in vivo. Agents and Actions, 1990; 29, 1-2, 50-51.

17. M. Reale, M.R. Panara, M. Bongrazio, R.C. Barbacane, P. Conti, C. Franceschi, I.

Caruso, F. Bersani and G.E. Gigante. Enhancing effect of electromagnetic exposure on calcium ionophore (A23187), but not IL-1-induced TxA2 release by human neutrophils. Int.J.Immunopathol. Pharmacol. 1991; 4, 55-60.

18. Conti P, Reale M, Barbacane RC, Panara MR, Bongrazio M. Inhibition of leukotriene

B4 in neutrophils by lipoxins A4 and B4. Agents Actions. 1991;32(1-2):85-87.

19. Conti P, Reale M, Barbacane RC, Panara MR, Bongrazio M, Dempsey RA, Dinarello CA. Reduced mitogen stimulation of DNA synthesis in human lymphocytes by a human recombinant interleukin-1 receptor antagonist. Immunol Lett. 1991;28(1):19-25.

20. Conti P, Reale M, Panara MR, Barbacane RC, Bongrazio M, Dempsey RA.Human recombinant interleukin-1 receptor antagonist inhibits lymphocyte blastogenesis induced by concanavalin A. Restorative effect of hrIL-1. FEBS Lett. 1991; 29;286(1-2):137-141.

21. Conti P, Dempsey RA, Reale M, Barbacane RC, Panara MR, Bongrazio M, Mier

JW.Activation of human natural killer cells by lipopolysaccharide and generation of interleukin-1 alpha, beta, tumour necrosis factor and interleukin-6. Effect of IL-1 receptor antagonist. Immunology. 1991;73(4):450-456.

22. Conti P, Reale M, Barbacane RC, Panara MR, Bongrazio M, Fiore S, Mier JW,

Dempsey RA. Granulocyte-macrophage colony stimulating factor potentiates human polymorphonuclear leukocyte aggregation responses to formyl-methionyl-leucyl-phenylalanine. Immunol Lett. 1992;32(1):71-79.

23. Conti P, Reale M, Barbacane RC, Panara MR, Bongrazio M, Theoharides TC. Role of

lipoxins A4 and B4 in the generation of arachidonic acid metabolites by rat mast cells and their effect on [3H]serotonin release. Immunol Lett. 1992;32(2):117-123.

24. Conti P, Panara MR, Porrini AM, Gambi D, Barbacane RC, Reale M, Bongrazio M, Dempsey RA. Inhibition of interleukin-1 (alpha and beta), interleukin-2 secretion and surface expression of interleukin-2 receptor (IL-2R) by a novel cytokine interleukin-1 receptor antagonist (IL-1ra). Scand J Immunol. 1992;36(1):27-33.

25. Conti P, Barbacane RC, Panara MR, Reale M, Placido FC, Fridas S, Bongrazio M, Dempsey RA. Human recombinant interleukin-1 receptor antagonist (hrIL-1ra) enhances the stimulatory effect of interleukin-2 on natural killer cell activity against MOLT-4 target cells.Int J Immunopharmacol. 1992;14(6):987-993.

26. Conti P, Feliciani C, Barbacane RC, Panara MR, Reale M, Placido FC, Sauder DN,

Dempsey RA, Amerio P. Inhibition of interleukin-1 beta mRNA expression and interleukin-1 alpha and beta secretion by a specific human recombinant interleukin-1 receptor antagonist in human peripheral blood mononuclear cells. Immunology. 1992;77(2):245-250.

27. Conti P, Panara MR, Barbacane RC, Placido FC, Bongrazio M, Reale M, Dempsey RA,

Fiore S. Blocking the interleukin-1 receptor inhibits leukotriene B4 and prostaglandin E2 generation in human monocyte cultures. Cell Immunol. 1992;145(1):199-209.

28. Conti P, Panara MR, Barbacane RC, Bongrazio M, Dempsey RA, Reale M. Human recombinant IL-1 receptor antagonist (IL-1Ra) inhibits leukotriene B4 generation from human monocyte suspensions stimulated by lipopolysaccharide (LPS).Clin Exp Immunol. 1993;91(3):526-531.

29. Conti P, Panara MR, Fridas S, Barbacane RC, Grilli A, Placido FC, Reale M, Fiore S.

Inhibition of granuloma formation induced by potassium permanganate in the mouse by a specific human recombinant receptor antagonist for interleukin-1 (hrIL-1ra). Cell Immunol. 1993;147(2):446-457.

30. Conti P, Reale M, Panara MR, Fridas S, Placido FC, Barbacane RC. Interleukin-1

receptor antagonist inhibits calcium accumulation in in vivo chronic granuloma induced by potassium permanganate. Calcif Tissue Int. 1993;52(4):300-304.

31. Conti P, Barbacane RC, Felaco M, Grilli A, Placido FC, Reale M. Human recombinant

interleukin-1 receptor antagonist (hrIL-1RA) inhibits prostaglandin E2 (PGE2) generation but not alkaline phosphatase activity in in vivo chronic granulomatous tissue induced by KMnO4. Immunol Lett. 1993;37(1):1-6.

32. Conti P, Reale M, Stuard S, Spoto G, Picerno F, Ferrara T, Placido FC, Barbacane RC,

Albertazzi A, Errichi BM. Reduced human lymphocyte blastogenesis and enhancement of adenosine triphosphate (ATP) by L-carnitine. Mol Cell Biochem. 1994;131(1):1-8.

33. Conti P, Reale M, Nicolai M, Barbacane RC, Placido FC, Iantorno R, Tenaglia R. Bacillus Calmette-Guérin potentiates monocyte responses to lipopolysaccharide-induced tumor necrosis factor and interleukin-1, but not interleukin-6 in bladder cancer patients. Cancer Immunol Immunother. 1994;38(6):365-371.

34. E. Porreca, M. Reale, C. Di Febbo, R.C. Barbacane, M.L. Castellani, F. Cipollone, L.

Carratelli, P. Conti, and F. Cuccurullo. Effect of MK-571, a selective leukotriene D4 receptor antagonist, on vascular smooth muscle cell proliferation and interleukin-1 release.Int. J. Immunopathol. Pharmacol. 1994; 7: 57-64.

35. Conti P, Reale M, Barbacane RC, Stuard S, Placido F. Effect of the antirheumatic agent

Tenidap on CD3, CD4, and CD8 expression and interleukin-1 and leukotriene B4

secretion in human peripheral blood mononuclear cells. Biochem Cell Biol. 1994;72(9-10):397-402.

36. Conti P, Bartle L, Barbacane RC, Reale M, Sipe JD. The down-regulation of IL-6-

stimulated fibrinogen steady state mRNA and protein levels by human recombinant IL-1 is not PGE2-dependent: effects of IL-1 receptor antagonist (IL-1RA). Mol Cell Biochem. 1995;142(2):171-178.

37. Porreca E, Di Febbo C, Reale M, Barbacane R, Mezzetti A, Cuccurullo F, Conti P.

Modulation of rat vascular smooth muscle cell (VSMC) proliferation by cysteinyl leukotriene D4: a role for mediation of interleukin 1. Atherosclerosis. 1995;113(1):11-18.

38. Conti P, Bartle L, Barbacane RC, Reale M, Placido FC, Sipe J. Synergistic activation of

serum amyloid A (SAA) by IL-6 and IL-1 in combination on human Hep 3B hepatoma cell line. Role of PGE2 and IL-1 receptor antagonist. Immunol Invest. 1995;24(3):523-535.

39. Porreca E, Conti P, Feliciani C, Di Febbo C, Reale M, Mincione G, Neri M, Amerio P,

Cuccurullo F. Cysteinyl-leukotriene D4 induced IL-1 beta expression and release in rat vascular smooth muscle cells. Atherosclerosis. 1995;115(2):181-189.

40. Conti P, Boucher W, Letourneau R, Feliciani C, Reale M, Barbacane RC, Vlagopoulos P, Bruneau G, Thibault J, Theoharides TC. Monocyte chemotactic protein-1 provokes mast cell aggregation and [3H]5HT release. Immunology. 1995;86(3):434-440.

41. Conti P, Bouchet W, Feliciani C, Mammarella S, Kudchadker L, Barbacane RC, Reale M, Haggag I, Bruneau G, Thibault J, Theoharides TC. Effect of interleukin-1 receptor antagonist (IL-1RA) on histamine and serotonin release by rat basophilic leukemia cells (RBL-2H3) and peritoneal mast cells. Mol Cell Biochem. 1996;155(1):61-68.

42. Frydas S, Karagouni E, Dotsika E, Reale M, Barbacane RC, Vlemmas I, Anogianakis G, Trakatellis A, Conti P. Generation of TNF alpha, IFN gamma, IL-6, IL-4 and IL-10 in mouse serum from trichinellosis: effect of the anti-inflammatory compound 4-deoxypyridoxine (4-DPD).Immunol Lett. 1996;49(3):179-184.

43. Reale M, Barbacane RC, Frydas S, Anogianakis G, Trakatellis A, Dimitriadou D,

Vacalis D, Placido FC, De Fazio P, Porreca E, Di Febbo C, Conti P.Human recombinant interleukin-1 beta induces thromboxane A2 release in polymorphonuclear leukocytes, macrophages and platelets: effect of IL-1 receptor antagonist. Mol Cell Biochem. 1996;159(2):163-168.

44. M. Reale, S. Frydas, R.C. Barbacane, P. Conti, F.C.Placido, I Cataldo, G. Anogianakis, D. Dimitriadou, D. Vacalis and A. Trakatellis. 1996. Generation of monocyte chemotactic protein-1(MCP-1) by rat peritoneal mast cells after LPS or TNF alpha activation. Int.J. Immunopathol. Pharmacol, 1996; 9:109-112,

45. Porreca E, Di Febbo C, Di Sciullo A, Angelucci D, Nasuti M, Vitullo P, Reale M, Conti

P, Cuccurullo F, Poggi A. Cysteinyl leukotriene D4 induced vascular smooth muscle cell proliferation: a possible role in myointimal hyperplasia. Thromb Haemost. 1996;76(1):99-104.

46. Porreca E, Reale M, Di Febbo C, Di Gioacchino M, Barbacane RC, Castellani ML,

Baccante G, Conti P, Cuccurullo F. Down-regulation of cyclooxygenase-2 (COX-2) by interleukin-1 receptor antagonist in human monocytes. Immunology. 1996;89(3):424-429.

47. Di Febbo C, Reale M, Baccante G, Castellani ML, Placido F, Cuccurullo F, Porreca E.

Trasforming growth factor b1 induces IL-1 receptor antagonist gene expression and production an rat vascular smooth muscle cells. Atherosclerosis, 1997; 134, (1,2),

48. Porreca E, Di Febbo C, Reale M, Castellani ML, Baccante G, Barbacane R, Conti P, Cuccurullo F, Poggi A. Monocyte chemotactic protein 1 (MCP-1) is a mitogen for cultured rat vascular smooth muscle cells. J Vasc Res. 1997;34(1):58-65.

49. Reale M, Orso C, Castellani ML, Barbacane RC, Placido FC, Porreca E, Di Febbo C, Cataldo I, Vacalis D, Anogianakis G, Trakatellis A, Conti P. Infra-red laser irradiation enhances interleukin-1 receptor antagonist, increases 3H-thymidine incorporation and the release of [3H]arachidonic acid in human monocytes. Mol Cell Biochem. 1997;169(1-2):51-59.

50. Conti P, Pang X, Boucher W, Letourneau R, Reale M, Barbacane RC, Thibault J, Theoharides TC. Impact of Rantes and MCP-1 chemokines on in vivo basophilic cell recruitment in rat skin injection model and their role in modifying the protein and mRNA levels for histidine decarboxylase. Blood. 1997;89(11):4120-4127.

51. S. Frydas, M. Reale, R.C. Barbacane, P. Conti, F.C. Placido, I. Cataldo, D. Dimitriadou, A. Trakatellis and G. Anogianakis. Generation of monocyte chemotactic protein-1 (MCP-1) and TNF-alpha in mouse serum from trichinellosis. Int. J. Immunopathol. Pharmacol. 1997; 10:23-26.

52. Porreca E, Di Febbo C, Mincione G, Reale M, Baccante G, Guglielmi MD, Cuccurullo F, Colletta G. Increased transforming growth factor-beta production and gene expression by peripheral blood monocytes of hypertensive patients.Hypertension. 1997;30:134-139.

53. Conti P, Reale M, Barbacane RC, Frydas S, Felaco M, Grilli A, Placido FC, Cataldo I,

Feliciani C, Di Gioacchino M, Anogianakis G, Dimitriadou D, Vacalis D, Trakatellis A. Massive infiltration of basophilic cells in inflamed tissue after injection of RANTES. Immunol Lett. 1997;58(2):101-106.

54. Conti P, Pang X, Boucher W, Letourneau R, Reale M, Barbacane RC, Thibault J, Theoharides TC. Monocyte chemotactic protein-1 is a proinflammatory chemokine in rat skin injection sites and chemoattracts basophilic granular cells. Int Immunol. 1997;(10):1563-1570.

55. Conti P, Reale M, Feliciani C, Frydas S, Trakatellis M, Placido FC, Cataldo I, Di

Gioacchino M, Barbacane RC. Augmentation of monocyte chemotactic protein-1 and mRNA transcript in chronic inflammatory states induced by potassium permanganate (KMnO4) in vivo. Immunology. 1997;92(2):300-306.

56. Conti P, Pang X, Boucher W, Letourneau R, Reale M, Barbacane RC, Thibault J, Theoharides TC. RANTES is a pro-inflammatory chemokine and chemoattracts basophil cells to extravascular sites. J Pathol. 1997 ;183(3):352-358.

57. Conti P, Barbacane RC, Trakatellis M, Placido FC, Cataldo I, Reale M. Influence of

interleukin-1 receptor antagonist on [3H]serotonin and histamine release by rat basophilic leukemia-2H3 cells. Ann N Y Acad Sci. 1997;832:223-232.

58. De Luca G., Reale M., Iarlori C., Lugaresi A., Conti P., D. Gambi. RANTES and MCP-

1 secretion by mononuclear cells of patients with multiple sclerosis J.Neuroimmunology, 1998; 90 (1).

59. Di Febbo C, Baccante G, Reale M, Castellani ML, Angelini A, Cuccurullo F, Porreca

E. Transforming growth factor beta1 induces IL-1 receptor antagonist production and gene expression in rat vascular smooth muscle cells. Atherosclerosis. 1998;136(2):377-382.

60. Reale M, Frydas S, Barbacane RC, Placido FC, Cataldo I, Vacalis D, Trakatellis A,

Anogianakis G, Felaco M, Di Gioacchino M, Conti P. Induction of monocyte chemotactic protein-1 (MCP-1) and TNF alpha by Trichinella spiralis in serum of mice in vivo. Mol Cell Biochem. 1998;179(1-2):1-5.

61. Conti P, Barbacane RC, Di Gioacchino M, Reale M. Will MCP-1 and RANTES take

center stage in inflammatory diseases including asthma? Allergy Asthma Proc. 1998;19(3):121-12

62. Bonomini M, Reale M, Santarelli P, Stuard S, Settefrati N, Albertazzi A. Serum levels

of soluble adhesion molecules in chronic renal failure and dialysis patients. Nephron. 1998;79(4):399-407.

63. Conti P, Reale M, Barbacane RC, Letourneau R, Theoharides TC. Intramuscular

injection of hrRANTES causes mast cell recruitment and increased transcription of histidine decarboxylase in mice: lack of effects in genetically mast cell-deficient W/WV mice. FASEB J. 1998;12(15):1693-1700.

64. Conti P, Reale M, Barbacane RC, Felaco M, Grilli A, Theoharides TC. Mast cell

recruitment after subcutaneous injection of RANTES in the sole of the rat paw. Br J Haematol. 1998;103(3):798-803.

65. Boscolo P., Di Stefano F., Di Sciascio M.B., Verna N., Reale M., Cervone M., Simone

R., M. Di Gioacchino. Preliminary Study on the effects of electromagnetic fields on the human immune system. Int. J. Immunopathol and Pharmacol. 1999; 12, 2 (S): 54.

66. Boscolo P., M. Di Gioacchino, Di Stefano F., Di Sciascio M.B., Verna N., Di Giacomo F., Reale M., Cervone M., Lizza M, Sabbioni E. : Expression of lymphocyte subpopulation, cytokine serum levels, and blood and urinary trace elements in atopic women exposed to an urban environment. Int. J. Immunopathol and Pharmacol. 1999;12, 2 (S): 60.

67. Conti P, Feliciani C, Barbacane RC, Frydas S, Placido FC, Cataldo I, Reale M. Monocyte chemotactic protein-1 gene expression and translation in formed granulomatous calcified tissue in vivo. Calcif. Tissue Int. 1999;64(1):57-62.

68. Boscolo P, Di Gioacchino M, Sabbioni E, Benvenuti F, Conti P, Reale M, Bavazzano

P, Giuliano G. Expression of lymphocyte subpopulations, cytokine serum levels, and blood and urinary trace elements in asymptomatic atopic men exposed to an urban environment. Int Arch Occup Environ Health. 1999;72(1):26-32.

69. Boscolo P, Andreassi M, Sabbioni E, Reale M, Conti P, Amerio P, Di Gioacchino M.

Systemic effects of ingested nickel on the immune system of nickel sensitised women. Life Sci. 1999;64(17):1485-1491.

70. Frydas S, Reale M, Vacalis D, Barbacane RC, Placido FC, Cataldo I, Di Gioacchino M,

Karagouni E, Dotsika E, Anogiannakis G, Trakatellis A, Conti P. IgG, IgG1 and IgM response in Trichinella spiralis-infected mice treated with 4-deoxypirydoxine or fed a Vitamin B6-deficient diet. Mol Cell Biochem. 1999;194(1-2):47-52.

71. Conti P, Barbacane RC, Reale M. Chemokines in inflammatory states. Allergy Asthma

Proc. 1999;20(4):205-208.

72. Frydas S, Papaioanou N, Vlemmas I, Theodoridis I, Anogiannakis G, Vacalis D, Trakatellis A, Barbacane RC, Reale M, Conti P.Vitamin B6-deficient diet plus 4-deoxypyridoxine (4-DPD) reduces the inflammatory response induced by T. spiralis in diaphragm, masseter and heart muscle tissue of mice. Mol Cell Biochem. 1999;197(1-2):79-85.

73. Conti P, Reale M, Grilli A, Barbacane RC, Di Luzio S, Di Gioacchino M, De Lutiis MA, Felaco M. Effect of electromagnetic fields on several CD markers and transcription and expression of CD4. Immunobiology. 1999;201(1):36-48.

74. Porreca E, Sergi R, Baccante G, Reale M, Orsini L, Febbo CD, Caselli G, Cuccurullo F,

Bertini R. Peripheral blood mononuclear cell production of interleukin-8 and IL-8-dependent neutrophil function in hypercholesterolemic patients. Atherosclerosis. 1999;146(2):345-350

75. Felaco M, Reale M, Grilli A, De Lutiis MA, Barbacane RC, Di Luzio S, Conti P.

Impact of extremely low frequency electromagnetic fields on CD4 expression in peripheral blood mononuclear cells. Mol Cell Biochem. 1999;201(1-2):49-55.

76. Iarlori C, Reale M, Lugaresi A, De Luca G, Bonanni L, Di Iorio A, Feliciani C, Conti P, Gambi D. RANTES production and expression is reduced in relapsing-remitting multiple sclerosis patients treated with interferon-beta-1b. J Neuroimmunol. 2000;107(1):100-107.

77. Boscolo P, Di Gioacchino M, Sabbioni E, Di Giacomo F, Reale M, Volpe AR, Di Sciascio MB, Conti P, Giuliano G. Lymphocyte subpopulations, cytokines and trace elements in asymptomatic atopic women exposed to an urban environment. Life Sci. 2000;67(10):1119-1126.

78. Felaco M, Grilli A, Gorbunov N, Di Napoli P, De Lutiis MA, Di Giulio C, Taccardi AA, Barsotti A, Barbacane RC, Reale M, Conti P. Endothelial NOS expression and ischemia-reperfusion in isolated working rat heart from hypoxic and hyperoxic conditions. Biochim Biophys Acta. 2000;1524(2-3):203-211.

79. Felaco M, Di Maio FD, De Fazio P, D'Arcangelo C, De Lutiis MA, Varvara G, Grilli A,

Barbacane RC, Reale M, Conti P. Localization of the e-NOS enzyme in endothelial cells and odontoblasts of healthy human dental pulp. Life Sci. 2000;68(3):297-306.

80. Reale M, Barbacane RC, DiGioacchino M, Felaco M, Croce A, Ferro FM, Lotti TM, Conti P. Differential expression and secretion of RANTES and MCP-1 in activated peripheral blood mononuclear cell cultures of atopic subjects. Immunol Lett. 2001;76(1):7-14.

81. Cipollone F, Marini M, Fazia M, Pini B, Iezzi A, Reale M, Paloscia L, Materazzo G, D'Annunzio E, Conti P, Chiarelli F, Cuccurullo F, Mezzetti A. Elevated circulating levels of monocyte chemoattractant protein-1 in patients with restenosis after coronary angioplasty. Arterioscler Thromb Vasc Biol. 2001;21(3):327-334.

82. Bonomini M, Sirolli V, Reale M, Arduini A. Involvement of phosphatidylserine

exposure in the recognition and phagocytosis of uremic erythrocytes. Am J Kidney Dis. 2001;37(4):807-814.

83. Conti P, Barbacane RC, Feliciani C, Reale M. Expression and secretion of RANTES by

human peripheral blood CD4+ cells are dependent on the presence of monocytes. Ann Clin Lab Sci. 2001;31(1):75-84.

84. Boscolo P, Bergamaschi A, Di Sciascio MB, Benvenuti F, Reale M, Di Stefano F,

Conti P, Di Gioacchino M. Effects of low frequency electromagnetic fields on expression of lymphocyte subsets and production of cytokines of men and women employed in a museum. Sci Total Environ. 2001;270(1-3):13-20.

85. Boscolo P, Di Sciascio MB, D'Ostilio S, Del Signore A, Reale M, Conti P, Bavazzano

P, Paganelli R, Di Gioacchino M. Effects of electromagnetic fields produced by radiotelevision broadcasting stations on the immune system of women. Sci Total Environ. 2001;273(1-3):1-10.

86. Di Luzio S, Felaco M, Barbacane RC, Frydas S, Grilli A, Castellani ML, Macrì MA, Di

Gioacchino M, Merlitti D, De Lutiis MA, Masci S, Di Giulio C, Cacchio M, Reale M. Effects of 50 Hz sinusoidal electromagnetic fields on MCP-1 and RANTES generated from activated human macrophages. Int J Immunopathol Pharmacol. 2001;14(3):169-172

87. Iarlori C, Reale M, De Luca G, Di Iorio A, Feliciani C, Tulli A, Conti P, Gambi D,

Lugaresi A. Interferon beta-1b modulates MCP-1 expression and production in relapsing-remitting multiple sclerosis. J Neuroimmunol. 2002;123(1-2):170-179

88. M.Reale, R.C. Barbacane. Cyclosporins, adhesion molecules and chemokines: Involvement in Disease. Int J Immunopathol Pharmacol. 2002;15(1 S):49-53

89. Reale M, Intorno R, Tenaglia R, Feliciani C, Barbacane RC, Santoni A, Conti P. Production of MCP-1 and RANTES in bladder cancer patients after bacillus Calmette-Guerin immunotherapy. Cancer Immunol Immunother. 2002;51(2):91-98.

90. Conti P, Frydas S, Reale M, Barbacane RC, Di Gioacchino M, Felaco M, Trakatellis A. Inhibition of MCP-1 and MIP-2 transcription and translation by mimosine in muscle tissue infected with the parasite Trichinella spiralis. Mol Cell Biochem. 2002;229(1-2):129-137

91. Conti P, Kempuraj D, Kandere K, Di Gioacchino M, Reale M, Barbacane RC,

Castellani ML, Mortari U, Boucher W, Letourneau R, Theoharides TC. Interleukin-16 network in inflammation and allergy. Allergy Asthma Proc. 2002;23(2):103-108.

92. Di Gioacchino M, Sabbioni E, Di Giampaolo L, Schiavone C, Di Sciascio MB, Reale M, Verna N., Qiao N, Paganelli R, Conti P, Boscolo P. In vitro effects of vanadate on human immune functions. Ann Clin Lab Sci. 2002;32(2):148-154.

93. Frydas S, Papaioannou N, Reale M, Barbacane RC, Conti P. MCP-1 and MIP-2

response in Trichinella spiralis infected mice treated with 4-deoxypyridoxine (4-DPD). Immunol Lett. 2002;83(1):31-37.

94. Conti P, Kempuraj D, Di Gioacchino M, Boucher W, Letourneau R, Kandere K,

Barbacane RC, Reale M, Felaco M, Frydas S, Theoharides TC. Interleukin-6 and mast cells. Allergy Asthma Proc. 2002;23(5):331-335.

95. Di Gioacchino M, Verna N, Cavallucci E, Paolini F, Caruso R, Grana M, Schiavone C,

Di Iorio A, Ramondo S, Reale M, Paganelli R, Theoharides TC. Steroid and antihistamines modulate RANTES release in cultured peripheral blood mononuclear cells of atopic patients. Int J Immunopathol Pharmacol. 2002;15(1):27-34.

96. Conti P, Reale M, Barbacane RC, Castellani ML, Orso C. Differential production of

RANTES and MCP-1 in synovial fluid from the inflamed human knee. Immunol Lett. 2002;80(2):105-111.

97. Boscolo P, del Signore A, Sabbioni E, Di Gioacchino M, Di Giampaolo L, Reale M,

Conti P, Paganelli R, Giaccio M. Effects of resveratrol on lymphocyte proliferation and cytokine release. Ann Clin Lab Sci. 2003;33(2):226-231.

98. Reale M, Di Giulio C, Cacchio M, Barbacane RC, Grilli A, Felaco M, Bianchi G, Di

Gioacchino M, Conti P. Oxygen supply modulates MCP-1 release in monocytes from young and aged rats: decrease of MCP-1 transcription and translation is age-related. Mol Cell Biochem. 2003;248(1-2):1-6.

99. Paganelli R, Buttari B, Camera E, Dell'Anna ML, Mastrofrancesco A, Di Giampaolo L,

Reale M, Schiavone C, Verna N, Di Gioacchino M, Sabbioni E, Boscolo P, Picardo M. In vitro effects of nickel-sulphate on immune functions of normal and nickel-allergic subjects: a regulatory role for zinc. J Trace Elem Med Biol. 2003;17:11-15.

100. Reale M, Iarlori C, Gambi F, Feliciani C, Salone A, Toma L, DeLuca G, Salvatore M, Conti P, Gambi D. Treatment with an acetylcholinesterase inhibitor in Alzheimer

patients modulates the expression and production of the pro-inflammatory and anti-inflammatory cytokines. J Neuroimmunol. 2004;148(1-2):162-171.

101. Lugaresi A, Di Iorio A, Iarlori C, Reale M, De Luca G, Sparvieri E, Michetti A,

Conti P, Gambi D, Abate G, Paganelli R. IL-4 in vitro production is upregulated in Alzheimer's disease patients treated with acetylcholinesterase inhibitors. Exp Gerontol. 2004;39(4):653-657.

102. Gambi F, Reale M, Iarlori C, Salone A, Toma L, Paladini C, De Luca G, Feliciani

C, Salvatore M, Salerno RM, Theoharides TC, Conti P, Exton M, Gambi D. Alzheimer patients treated with an AchE inhibitor show higher IL-4 and lower IL-1 beta levels and expression in peripheral blood mononuclear cells. J Clin Psychopharmacol. 2004;24(3):314-321.

103. Di Gioacchino M, Di Giampaolo L, Verna N, Reale M, Di Sciascio MB, Volpe

AR, Carmignani M, Ponti J, Paganelli R, Sabbioni E, Boscolo P. In vitro effects of platinum compounds on lymphocyte proliferation and cytokine release. Ann Clin Lab Sci. 2004;34(2):195-202.

104. Di Giampaolo L, Di Gioacchino M, Ponti J, Sabbioni E, Castellani ML, Reale M,

Toto E, Verna N, Conti P, Paganelli R, Boscolo P. "In vitro" comparative immune effects of different titanium compounds. Int J Immunopathol Pharmacol. 2004;17:115-122.

105. Boscolo P, Di Giampaolo L, Reale M, Castellani ML, Ritavolpe A, Carmignani

M, Ponti J, Paganelli R, Sabbioni E, Conti P, Di Gioacchino M. Different effects of platinum, palladium, and rhodium salts on lymphocyte proliferation and cytokine release. Ann Clin Lab Sci. 2004;34(3):299-306.

106. Reale M, Iarlori C, Gambi F, Lucci I, Salvatore M, Gambi D.

Acetylcholinesterase inhibitors effects on oncostatin-M, interleukin-1 beta and interleukin-6 release from lymphocytes of Alzheimer's disease patients. Exp Gerontol. 2005;40(3):165-171.

107. Comani S, Mantini D, Merlino B, Reale M, Di Luzio S, Romani GL. Integrated

software suite for magnetocardiographic data analysis--a proposal based on an interactive programming environment. Methods Inf Med. 2005;44(1):114-123.

108. Iarlori C, Gambi D, Gambi F, Lucci I, Feliciani C, Salvatore M, Reale M. Expression and production of two selected beta-chemokines in peripheral blood mononuclear cells from patients with Alzheimer's disease. Exp Gerontol. 2005;40(7):605-611.

109. Boscolo P, Di Giampaolo L, Qiao N, Reale M, Castellani ML, Lucci I, Travaglini

P, Kouri M, Verna N, Volpe AR, Carmignani M, Paganelli R, Di Gioacchino M. Inhibitory effects of cadmium on peripheral blood mononuclear cell proliferation and cytokine release are reversed by zinc and selenium salts. Ann Clin Lab Sci. 2005;35(2):115-120.

110. Cacchio M, Lucci I, Di Giulio C, Bianchi G, Grilli A, Patruno A, Reale M. MCP-1 and MIP-2 expression and production in BB diabetic rat: effect of chronic hypoxia. Mol Cell Biochem. 2005;276(1-2):105-111.

111. Reale M, Iarlori C, Gambi F, Feliciani C, Isabella L, Gambi D. The

acetylcholinesterase inhibitor, Donepezil, regulates a Th2 bias in Alzheimer's disease patients. Neuropharmacology. 2006;50(5):606-613.

112. Reale M, De Lutiis MA, Patruno A, Speranza L, Felaco M, Grilli A, Macrì MA,

Comani S, Conti P, Di Luzio S. Modulation of MCP-1 and iNOS by 50-Hz sinusoidal electromagnetic field. Nitric Oxide. 2006;15(1):50-57.

113. Di Giampaolo L, Di Donato A, Antonucci A, Paiardini G, Travaglini P, Spagnoli

G, Magrini A, Reale M, Dadorante V, Iannaccone U, Di Sciascio MB, Di Gioacchino M, Boscolo P. Follow up study on the immune response to low frequency electromagnetic fields in men and women working in a museum. Int J Immunopathol Pharmacol. 2006;19:37-42

114. Boscolo P, Di Giampaolo L, Di Donato A, Antonucci A, Paiardini G, Morelli S,

Vasile R, Spagnoli G, Reale M, Dadorante V, Kouri M, Di Gioacchino M. The immune response of women with prolonged exposure to electromagnetic fields produced by radiotelevision broadcasting stations. Int J Immunopathol Pharmacol. 2006;19:43-48.

115. Di Donato A, Di Giampaolo L, Reale M, Dadorante V, Alparone F, Stocchi M, Fattorini E, Di Gioacchino M, Magrini A, Boscolo P. Effect of occupational stress and anxiety on natural killer lymphocyte activity of men and women employed in a university. Int J Immunopathol Pharmacol. 2006;19:79-84.

116. C. Iarlori, D. Gambi, A. Lugaresi, A. Patruno, M. Felaco, M. Salvatore, L. Speranza, M. Reale. Reduction of free radicals in Multiple Sclerosis: effect of glatiramer acetate (Copaxone®) Multiple Sclerosis Journal 2008,14:739-748

117. G. Vianale, M. Reale, P. Amerio, M. Stefanachi, S. Di Luzio, and R. Muraro. Extremely Low Frequency Electromagnetic Field (ELF-EMF) enhances human keratinocyte cell growth and decreases pro-inflammatory chemokines production. British Journal of Dermatology 2008; 158(6):1189-1196.

118. M. Reale, C.Iarlori, C. Feliciani, D.Gambi. Peripheral chemokine receptors, their

ligands, cytokines and Alzheimer's disease. Journal of Alzheimer’s Disease, 2008; 14 (2): 147-159

119. Boscolo P, Di Donato A, Di Giampaolo L, Forcella L, Reale M, Dadorante V,

Alparone F, Pagliaro S, Kouri M, Magrini A, Fattorini E. Blood natural killer activity is reduced in men with occupational stress and job insecurity working in a university. Int Arch Occup Environ Health. 2009, 82(6):787-94.

120. M. Reale, C Iarlori, A Thomas, D Gambi, B Perfetti, M. Di Nicola, M Onofrj.

Peripheral cytokines profile in Parkinson’s Disease. Brain, Behavior and Immunity 2009 Jan; 23(1):55-63.

121. Maccallini C, Patruno A, Besker N, Alì JI, Ammazzalorso A, De Filippis B, Franceschelli S, Giampietro L, Pesce M, Reale M, Tricca ML, Re N, Felaco M, Amoroso R. Synthesis, biological evaluation and docking studies of N-substituted acetamidines as selective inhibitors of inducible nitric oxide synthase J Med Chem. 2009. Mar 12;52(5):1481-5.

122. Patruno A, Amerio P, Pesce M, Vianale G, Di Luzio S, Tulli A, Franceschelli S,

Grilli A, Muraro R, Reale M. Extremely low frequency electromagnetic field (elf-emf) modulate iNOS, eNOS and Cox-2 expressions in the human keratinocyte cell line hacat: potential therapeutical effects in wound healing. British Journal of Dermatology 2010 162, pp258–266

123. Amerio P, Vianale G, Reale M, Trubiani O, Muraro R, Tulli A, Piattelli A. The

effect of deproteinized bovine bone on osteoblast growth factors and pro-inflammatory cytokine production. Clinical Oral Implants Research 21, 2010 (6):650-5.; 650–655.ISSN 0905-7161

124. Kamal MA, Reale M, Al-Jafari AA. Multiple Approaches to Analyse the Data for Rat Brain Acetylcholinesterase Inhibition by Cyclophosphamide. Neurochem Res. 2010. 35(10):1501-9.

125. Speranza L, Franceschelli S, Pesce M, Reale M, Menghini L, Vinciguerra I, De Lutiis MA, Felaco M, Grilli A. Antiinflammatory effects in THP-1 cells treated with verbascoside. Phytother Res. 2010;24(9):1398-404.

126. Reale M, Patruno A, De Lutiis MA, Pesce M, Felaco M, Di Giannantonio M, Di Nicola M, Grilli A.Dysregulation of chemo-cytokine production in schizophrenic patients versus healthy controls. BMC Neurosci. 2011 Jan 25;12(1):13.

127. Boscolo P., Di Gioacchino M., Reale M., Muraro R., L. Di Giampaolo. Work stress and innate response. Int. J. Immunopath.Pharmacol. 2011, 24 (S1): 51-54.

128. Patruno A, Pesce M, Marrone A, Speranza L, Grilli A, De Lutiis MA, Felaco M, Reale M.Activity of matrix metallo proteinases (MMPs) and the tissue inhibitor of MMP (TIMP)-1 in electromagnetic field-exposed THP-1 cells. J Cell Physiol. 2011 Sep 16. doi: 10.1002/jcp.23024 .

129. Reale M, Vianale G, Lotti LV, Mariani-Costantini R, Perconti S, Cristaudo A, Leopold K, Antonucci A, Di Giampaolo L, Iavicoli I, Di Gioacchino M, Boscolo P. Effects of palladium nanoparticles on the cytokine release from peripheral blood mononuclear cells of palladium-sensitized women. J Occup Environ Med. 2011 Sep;53(9):1054-60. doi: 10.1097/JOM.0b013e318228115e. .

130. Reale M, Boscolo P, Bellante V, Tarantelli C, Di Nicola M, Forcella L, Li Q, Morimoto K, Muraro R. Daily intake of Lactobacillus casei Shirota increases natural killer cell activity in smokers. Br J Nutr. 2011 Dec 6:1-7 .

131. Patruno A, Tabrez S, Amerio P, Pesce M, Vianale G, Franceschelli S, Grilli A, Kamal MA, Reale M. Kinetic Study on the Effects of Extremely Low Frequency Electromagnetic Field on Catalase, Cytochrome P450, Inducible Nitric Oxide Synthase in Human HaCaT and THP-1 Cell Lines. CNS Neurol Disord Drug Targets. 2011 Dec 1;10(8):936-44.

132. Al Jafari AA, Shakil S, Reale M, Kamal MA. Human Platelet Acetylcholinesterase Inhibition by Cyclophosphamide: A Combined Experimental and Computational Approach. CNS Neurol Disord Drug Targets. 2011 Dec 1;10(8):936-44.

133. Reale M, Kamal MA, Velluto L, Gambi D, Di Nicola M, Greig NH. Relationship between Inflammatory Mediators, Aβ Levels and APOE Genotype in Alzheimer's Disease. Curr Alzheimer Res. May;9(4):447-57, 2012

134. Reale M, Pesce M, Priyadarshini M, Kamal MA, Patruno A. Mitochondria as an Easy Target to Oxidative Stress Events in Parkinson's Disease. CNS Neurol Disord Drug Targets Jun 1;11(4):430-8. 2012,

135. Priyadarshini M, Kamal MA, Greig NH, Reale M, Abuzenadah AM, Chaudhary A, Damanhouri GA. Alzheimers Disease and Type 2 Diabetes: Exploring the Association to Obesity and Tyrosine Hydroxylase. CNS Neurol Disord Drug Targets. Jun 1;11(4):482-9 2012 May 11.

136. Reale M., De Angelis F. , Di Nicola M. , Capello E. , Di Ioia M. , De Luca G. , Lugaresi A., Tata A.M. Relation between Pro-inflammatory Cytokines and Acetylcholine Levels in Relapsing-Remitting Multiple Sclerosis Patients. Int. J. Mol. Sci. 2012, 13(10), 12656-12664; doi:10.3390/ijms131012656

137. Yu QS, Reale M, Kamal MA, Holloway HW, Luo W, Sambamurti K, Ray B, Lahiri DK, Rogers JT, Greig NH. Synthesis of the Alzheimer drug Posiphen into its primary metabolic products (+)-N1-norPosiphen, (+)-N8-norPosiphen and (+)-N1, N8-bisnorPosiphen, their inhibition of amyloid precursor protein, α-synuclein synthesis, interleukin-1β release, and cholinergic action. Antiinflamm Antiallergy Agents Med Chem. 2013 Jan 22. [Epub ahead of print]PMID: 23360256

138. Reale M, Tata AM.Modulation of Cholinergic System Activity in Neuronal and Non-Neuronal Tissues: Therapeutic Implications. Antiinflamm Antiallergy Agents Med Chem. 2013 Jan 22. [Epub ahead of print] PMID: 23360255

Congress M.Reale, D. Gambi, M. Onofrj, M. Salvatore, A.Thomas, C. Iarlori. Immunological involvement in the pathogenesis of Parkinson’s disease. XVI Meeting of the European Neurological Society ENS 2006. May 27-31, Lousanne, Switzerland 2006.

D.Gambi, M.Reale, M.Onofrj, A.Thomas and C.Iarlori. Cytokine involvement in neurodegenerative disorders 8th International Conference of Neuroimmunology (ISNI 2006)， Nagoya, Japan,OCT. 15-19, 2006.

Iarlori, M. Reale, A. Patruno, A. Thomas, M. Onofrj, D. Gambi. Inducible NOS (iNOS) and peroxynitrite determination reveal continous inflammation in Parkinson's disease. 8th Internation Conference AD/PD 2007. Salzburg, Austria, March 14-18, 2007

Gambi, M. Reale, A. Patruno, A. Thomas, M. Onofrj, C. Iarlori. Inducible NOS(iNOS) expression in Parkinson's disease. XXXVIII CONGRESSO SIN - FIRENZE ottobre, 13 -17, 2007 Velluto L., Reale M., Iarlori C., Gambi D. Levels of soluble adhesion molecules in APOEε4 carriers Alzheimer’s patients. XXXIX Congress of the Italian Neurological Society. Naples 2008. Neurological Sciences,Vol.29, 2008

Reale M., Bellante V., Gambi D. and Iarlori C. Effect of amyloid peptide and acetylcholinesterase inhibitor on PBMC cultures. Controversies in Neurology (CONy), Athens, Greece, October 23-26, 2008 Reale M., Iarlori C., Velluto L., Gambi D. Impact of apoE genotype on soluble adhesion molecules in Alzheimer’s patients.ENS, Eigteenth meeeting, Nice-France. June 7-11,2008 Reale M., Gatta V., Di Nicola M., Stuppia L., Palka G., Iarlori C., Thomas A., Onofrj M., Gambi D. polymorphisms of chemokine and chemokine receptor genes in ad and pd patients. 9th International Conference AD/PD. Prague, Czech Republic, March 11–15, 2009. Reale M., Di Nicola M., Velluto L., Iarlori C., Bellante V. and Gambi D. Impact of apoE genotype on circulating IL-18 and Amyloid beta levels in Alzheimer’s disease. ICAD in Vienna, Austria, July 11-16, 2009. Reale M., Velluto L., Iarlori C., Bellante V. and Gambi D. Circulating levels of il-18 and apoe genotype in alzheimer’s patients. IAGG Paris, 5-9 July, 2009. Reale M., Velluto L., Di Nicola M., Bellante V., Gambi D. Apoe genetype and plasma levels of IL-18 in alzheimer's patients. The 3rd World Congress on Controversies in Neurology (CONy), Prague, Czech Republic, October 8-11, 2009 Di Nicola M., Reale M., Mattei P., Colagrande V., Ballone E.The association between chemokine receptor gene polymorphisms and two neurodegenerative disorders:Alzheimer’s and Parkinson’s disease.Congresso Nazionale SISMEC. Dalla genetica all’ambiente, Pavia 16-19 Settembre, 2009 Patruno A, Pesc M., Franceschelli S.,Vinciguerra I., Reale M., Speranza L., Grilli A., De Lutiis M.A., Felaco M. Effetto dei campi elettromagnetici a bassa frequenza (ELF-EMF) sulla modulazione dei mediatori infiammatori e sulla proliferazione in una linea cellulare di cheratinociti umana (HaCaT). XI Congresso Nazionale AIBG. Palermo 7-10 Ottobre, 2009. Reale M., Iarlori C., Bellante V., Di Nicola M., and D. Gambi. Imbalance in Interleukin-18 and Interleukin-18 binding protein in AD patients.10th International Congress of Neuroimmunology Sitges (Barcellona) Spain. October 26th-30th, 2010. Vianale G., Costantini E., Muraro R., Gambi D., Tata A.M., M. Reale. Transcriptional analysis of T cell regulatory cytokines in Miltiple Sclerosis patients. The 4rd World Congress on Controversies in Neurology (CONy), Barcelona, Spain. October 28-31, 2010 Patruno Antonia, Pesce Mirko, Speranza Lorenza, Franceschelli Sara, Vinciguerra Isabella, De Lutiis Mara anna, Zara Susy, Reale Marcella, Vianale Giovina, Amerio Paolo, Grilli Alfredo, Felaco Mario Extremely low frequency electromagnetic fields (ELF-EMF) effect on morphology and gentic expression profile of a human keratinocyte (HaCaT). XII Congresso Nazionale AIBG 8-9 Ottobre 2010 Trento Marcella Reale, Carla Iarlori, Veronica Bellante, Domenico Gambi and Nigel H. Greig.

Butyrylcholinesterase inhibitors as prospective therapeutic agents of Alzheimer Disease. VII European Congress Healthy and active ageing forall Europeans "II". April 14th-17th, 2011 Bologna.

Marcella Reale, Paolo Boscolo, Veronica Bellante, Chiara Tarantelli, Marta Di Nicola, Laura Forcella, Qing Li, Kanehisa Morimoto and Raffaella Muraro. Lactobacillus casei Shirota daily intake improves NK cytotoxicity in smokers in a randomized controlled trial. The 6th InternationalYakult Symposium” May 26th - 27th, 2011, Vienna M. Reale, F. De Angelis, E. Capello, M. Di Ioia, G. De Luca, A. Lugaresi and A.M. Tata Non-neuronal acetylcholine: a new modulator of immune responses in multiple sclerosis patients. Convegno AINP 24 Giugno 2011. Genova Tata A.D., F. De Angelis, A. Bernardo, L. Minghetti, E. Capello, M. Di Ioia, G. De Luca, A. Lugaresi, M. Reale. Acetylcholine in multiple sclerosis: possible involvement in the modulation of the immune response and in oligodendrocyte recruitment. Third International Symposim on non neuronal acetylcholine, a Groningen,Olanda, 24-26 Aug. 2011. Velluto L., Iarlori C., Costantini E. , Gambi D., Di Nicola M. Reale M. Peripheral inflammatory markers in patients with Alzheimer's disease: relationship with ApoE genotype. XLII SIN, Torino 22-24 Oct., 2011 M. Reale, F. De Angelis, G. Vianale, M. di Ioia, G. De Luca, A. Lugaresi and A.M. Tata. Modulation of the immune response in multiple sclerosis patients: effect of non-neuronal acetylcholine. XLII SIN, Torino 22-24 Oct., 2011 G. Vianale, E.Costantini, Di Nicola, M.Auriemma, P.Amerio, M.Reale. Effect of iloprost treatment withdrawal during summer time on the expression of proinflammatory cytokines in systemic sclerosis. The 8th International Congress on Autoimmunity - AUTO 2012. Granada, Spain, May 9- 13, 2012. M.Reale, A.M. Tata., S.Biagioni, C. D’Angelo, E.Costantini, M. Di Nicola, L. Velluto: BuChE, AChE and ACh levels in serum and CSF of RR-MS Patients. 11th int. Conf. On Alzheimer’s & Parkinson’s Disease. AD/PD 2013. Florence, Italy, March 6-10, 2013. BOOK Marcella Reale, Carla Iarlori, Claudio Feliciani, Domenico Gambi. Chemokine Involvement in Alzheimer's Disease Pathogenesis: Implication for Peripheral Inflammatory Process. Progress in Chemokine Research, Ed. W.P. Linker, Chap.12.. ISBN 978-1-60021-641-1. Nova Science Publisher,Inc. 2007 Lucia Velluto, Carla Iarlori, Domenico Gambi, Marcella Reale CYTOKINES AND ALZHEIMER’S DISEASE. Cytokines: Preedy, Victor R.; Hunter, Ross. Taylor & Francis Inc. ISBN: 9781578086900 June 2011 Carla Iarlori, Domenico Gambi, Marcella Reale PARKINSON’S DISEASE AND CYTOKINES. Cytokines: Preedy, Victor R.; Hunter, Ross. Taylor & Francis Inc. ISBN: 9781578086900 June 2011 Reale M. Cytokine network as attractive therapeutic target for neurodegenerative diseases. In "Cytokines: Mechanisms, Functions and Abnormalities " NOVA SCIENCE PUBLISHERS, INC (In press)