04/22/23 Prof. Giancarlo Pantaleoni : Farmacologo- Idroclimatologo

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Coherence 2006 Il ciclo e la chimica-fisica dell’acqua:

Venerdì 21 aprile 2006 ore 14.00-19.30Aula La Ginestra Dipartimento di Chimica

Università di Roma “La Sapienza”Piazzale Aldo Moro 1 Roma

04/22/23 Prof. Giancarlo Pantaleoni : Farmacologo- Idroclimatologo

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CARDIOTOSSICITA’ DEI FREONS (HALOCARBONS):

13) Cardiotossicità del diclorodifluoroetano.(G.L.Pantaleoni, L.Zoccolillo, A.P.Magrì) Rassegna Medicina Sperimentale,  22  (1975)  1-9.17) La tossicità degli idrocarburi alifatici alogenati contenenti fluoro. (G.Pantaleoni, L.Zoccolillo) Ann.Ist.Super.Sanità,  13  (1977)  343-352.

39) Halocarbons in Antarctic Surface Water.(L. Zoccolillo, M. Rellori)  International Journal of Environmental Analytical Chemistry,  55  (1994)  27-32 40) Halocarbons in Antarctic surface waters and snow. (L. Zoccolillo, L. Amendola, G.A. Tarallo) International Journal of Enviromental Analytical Chemistry, 63  (1996)  91-98

Saluto con riconoscenza i presenti ed in modo particolare i Colleghi di Chimica dell’Università di Roma “La Sapienza” che ospitano questo Convegno di Coherence2006

I primi anni della mia CARRIERA UNIVERSITARIA ho pubblicato con loro (….primo tra i Farmacologi italiani….) i primi lavori sui FREONS (HALOCARBONS)…quei gas che producono il buco d’Ozono e tanti problemi meteorologici attuali

Ecco i lavori fatti insieme…!

04/22/23 Prof. Giancarlo Pantaleoni : Farmacologo- Idroclimatologo

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« Back to article 

                                                            

Ozone hole over the South Pole during 25 September 2003 monitored by MIPAS. Ozone 'thickness' is measured in Dobson Units.

Credits: BIRA-IASB

ECCO IL BUCO D’OZONO OGGI….SUL POLO SUD

04/22/23 Prof. Giancarlo Pantaleoni : Farmacologo- Idroclimatologo

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Giancarlo Pantaleoni, Umberto Grieco, Bruno Brandimarte, Antonio Pacilè,:

Moderne acquisizioni di biochimicofisica sulle funzioni dell’acqua nelle cellule e negli interstizi

cellulari (in rapporto alle acque alimentari farmacologicamente testate e tutelate tossicologicamente) (esposizione del progetto presentato all’Unione Europea come Sistema Integrato per Il Controllo Strategico delle Acque (Sicsa) e del progetto di collaborazione Italo-Greca per il Termalismo.

1) - per produrre cibo per sé e per tutta la piramide alimentare che su di esse poggia,

2) - per approvvigionare d'ossigeno l'atmosfera.

1° FUNZIONE

Sono passate le ere ma ancora oggi le piante utilizzano la Fotosintesi nella sua incredibilmente semplice “miracolosa” equazione :

…acqua + anidride carbonica > glucosio + ossigeno

04/22/23 Prof. Giancarlo Pantaleoni : Farmacologo- Idroclimatologo

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These five letters are used to represent the different classes of a simple simbolic plant:B - fruits,F - flowers,I - internodes,L - leafs, andT - tubers

L’uomo Simbolico di VitruvioLa Pianta Simbolica

Tutti i Regni della Natura quindi tutte le Scienze sono interconnesse !

04/22/23 Prof. Giancarlo Pantaleoni : Farmacologo- Idroclimatologo

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04/22/23 Prof. Giancarlo Pantaleoni : Farmacologo- Idroclimatologo

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04/22/23 Prof. Giancarlo Pantaleoni : Farmacologo- Idroclimatologo

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Gli Atomi della Vita

04/22/23 Prof. Giancarlo Pantaleoni : Farmacologo- Idroclimatologo

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La VITA UMANA è partita da:

Las células procariontes no poseen un núcleo celular delimitado por una membrana.Los organismos procariontes son las células más simples que se conocen. En este grupo se incluyen las algas azul-verdosas y las bacterias.

I MITOCONDRI = AMICI PROCARIOTI

COLLABORANTI !!!

04/22/23 Prof. Giancarlo Pantaleoni : Farmacologo- Idroclimatologo

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Comportamenti Cellulari: di Procarioti ed Eucarioti

1. Taxis

2. Difesa Attiva

3. Difesa Passiva

4. CollaborazioneLa Collaborazione ha unito due Procarioti “tolleranti” ed ha creato un nuovo organismo Cellulare senza il quale le Piante e noi non esisteremmo !!!….

La Cellula EUCARIOTA

04/22/23 Prof. Giancarlo Pantaleoni : Farmacologo- Idroclimatologo

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Tutte le Cellule sono un IDROGEL

Tutte le Cellule sono una EVOLUZIONE ENERGETICA

un Assemblaggio cellulare eucariotico

è ENERGIA che prende coscienza di se stessa (chimica, fisica) e del mondo che lo circonda ( biologia, astrofisica, etc..etc.. )

La VITA proviene dal BIG BANG

L’essere umano è coordinato da TRE CERVELLI (Rettiliano-Ipotalamico-Neocorticale)

1°

2°

3°

…altre Definizioni VITA ESSERE

UMANO

La Scienza dice :

la Vita è COLLABORAZIONE

1

2

1

2

…da confermare..

confermato !

04/22/23 Prof. Giancarlo Pantaleoni : Farmacologo- Idroclimatologo

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LA COLLABORAZIONE

e quindi Inserita a livello

GENETICOMOLECOLARE

È già presente nel PSEUDO-CAOS del BIG BANG

L’ESSERE UMANO con difficoltà

ne prende coscienza SCIENTIFICAMENTE con la

NEOCORTEX (III° CERVELLO)

LE CELLULE lo fanno automaticamente

VITTORIO ERSPAMER lo ha scoperto nel suo TRIANGOLO PEPTIDICO

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THE PEPTIDE TRIANGLE di Vittorio Erspamer Farmacologo a ROMA“La Sapienza”

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BRAIN GUT SKINMammalian Mammalian Amphibian

PEPTIDES

Substance P Substance P Tachykinins

CCK CCK Caeruleins

Bradykinins Bradykinins Bradykinins

Gastrin Gastrin (7)  

Neurotensin Neurotensin Xenopsin

Enkephalins & endorphinsDermorphin-like peptides Enkephalins & endorphins Dermorphins

TRH TRH TRH

Somatostatin Somatostatin ?

Bombesin-like peptides Bombesin-like peptides Bombesin

VIP VIP VIP

Angiotensin I & II? Angiotensin I & II Crinia angiotensin II

Corticotropin-releasing factorSauvagine-like peptidesUrotensin-like peptides

Corticotropin-releasing factorSauvagine-like peptidesUrotensin-like peptides

Sauvagines

? ? Tryptophyllins

BIOGENIC AMINES

Indolealkylamines Indolealkylamines Indolealkylamines

Imidazolealkylamines Imidazolealkylamines Imidazolealkylamines

Catecolamines Catecolamines Catecolamines

References"Structure of sauvagine, a vasoactive peptide from the skin of a frog" by Montecucchi, P.C., Henschen, A. and Erspamer, V. (1981) in: "Structure and Activity of Natural Peptides" (Voelter, W. and Weitzel,G. eds.) De Gruyter, Berlin, pp 225 - 236"The brain-gut-skin triangle: new peptides" by Erspamer V, Melchiorri P, Broccardo M, Erspamer GF, Falaschi P, Improta G, Negri L, Renda T. (1981) in: Peptides 2 , Suppl. 2 , 7 - 16"The Tachykinin Peptide Family" by Cinzia Severini, Giovanna Improta, Giuliana Falconieri-Erspamer, Severo Salvadori, and Vittorio Erspamer in Pharmacol Rev 54:285-322, 2002, Review  - This paper is available online at http://pharmrev.aspetjournals.org"Making Magic" by Peter Gorman at: http://diseyes.lycaeum.org/fresh/nunu.htm  "AmphibiaWeb" at: http://elib.cs.berkeley.edu/aw/

04/22/23 Prof. Giancarlo Pantaleoni : Farmacologo- Idroclimatologo

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LA COLLABORAZIONE TRA CELLULE EUCARIOTE

VITTORIO ERSPAMER è lo scienziato che più di tutti ha scoperto con il suo TRIANGOLO PEPTIDICO

Il PRODOTTO INTRACELLULARE

della COLLABORAZIONE

È riversato nei Liquidi Interstiziali di ogni apparato ed organo

Lo studio dei LIQUIDI INTERSTIZIALI è stato affrontato da URBAN UNGHERSTEDT che ha messo a punto la MICRODIALISI

I LAVORI IN QUESTO SETTORE PROCEDONO..purtroppo… CON MOLTA DIFFICOLTÀ PER MANCANZA DI Fondi…!!!

04/22/23 Prof. Giancarlo Pantaleoni : Farmacologo- Idroclimatologo

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Lo studio del LIQUIDI INTERSTIZIALI CON IL METODO DELLA MICRODIALISI DI URBAN UNGHERTEDT PROCEDE A RILENTO PER MANCANZA DI SOLDI (=

FONDI)

COLLABORAZIONE TRA CELLULE-APPARATI-ORGANI

IN OGNI “PATOLOGIA”

POTREBBE RISOLVERE PROBLEMI DI BASE SULLA

E quindi indirizzare meglio

ogni TERAPIA !!!

04/22/23 Prof. Giancarlo Pantaleoni : Farmacologo- Idroclimatologo

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nell’ACQUA INTRACELLULARE

1. Sono riversati i prodotti cellulari di ogni apparato ed organo.

2. Dall’ acqua intracellulare passano poi nell’ acqua extracellulare (= spazi interstiziali)

3. Dagli spazi interstiziali si rovesciano nel torrente circolatorio e vengono diffusi alle cellule di ogni apparato ed organo che collaborano tutte tra loro per superare ogni emergenza.

PER ORA SAPPIAMO CHE:

Debbono essere studiate:

1) Le funzioni dell’Acqua intracellulare ed extracellulare.

2) Come, dove e perchè vengono trasportati i “Prodotti Cellulari “ scoperti da VITTORIO ERSPAMER, e da altri RICERCATORI… prima e dopo di lui.

Oggi si conosce quanto segue:

04/22/23 Prof. Giancarlo Pantaleoni : Farmacologo- Idroclimatologo

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A) Come l’acqua penetra nelle cellule

Funzioni dell’Acqua intracellulare

FunctionsWater serves as:1. a solvent for nutrients and delivers nutrients to cells, while it also 2. helps the body eliminate waste products from the cells. 3. Both the spaces between cells (intercellular spaces) and the spaces inside

cells (intracellular spaces) are filled with water. 4. Water lubricates joints and 5. acts as shock absorbers inside the eyes and spinal cord. 6. Amniotic fluid, which is largely water, protects the fetus from bumps

and knocks.7. Water also helps the body maintain a constant temperature by acting as

a thermostat. When a person is too hot, whether from being in a hot environment or from intense physical activity, the body sweats. When sweat evaporates, it lowers the body temperature and restores homeostasis.

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Water BalanceWater balance refers to the balance between the amount of water consumed and the amount of water excreted. The body's water content needs to be constant for optimal functioning. Cells are bathed in interstitial fluids (fluids from between cells) that contain nutrients. These fluids also carry metabolic wastes away from the cells. Intracellular fluids facilitate chemical reactions inside the cells, and they help maintain cell structure by adhering to the cell's larger molecules, such as proteins and glycogen. Body fluids contain solutes (chemical compounds that are soluble in water), which separate into charged particles, or ions, when dissolved in water. Intracellular fluids are high in potassium and phosphate ions, while interstitial fluids are high in sodium and chloride ions. These ions help to maintain the amount of fluids both within and outside the cells. Water molecules follow the solutes moving across cell membranes from a lower to higher solute concentration to maintain homeostasis. Water facilitates a number of critical body functions, from lubricating joints to carrying away cellular waste. Physical activity speeds fluid loss via perspiration. Athletes who do not drink enough water can easily become dehydrated, which can impair physical and mental functioning. Here, soccer star David Beckham drinks from a water bottle during a practice session.

04/22/23 Prof. Giancarlo Pantaleoni : Farmacologo- Idroclimatologo

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Water Intake RegulationWhen the body has lost a lot of water, the concentration of solutes in the blood becomes too high. The solutes attract water from the salivary glands, making the mouth dry and causing a person to feel thirsty. The sense of thirst is a craving for water or other fluids. When water loss is slow, a person may have time to feel thirsty enough to replenish the water loss. In cases where the water loss is excessive and acute, however, and replenishment is not adequate, a state of dehydration can occur. Dehydration is a state in which the body has lost so much water that normal physiologic functions cannot take place, resulting in symptoms such as fainting(= svenimento) and nausea.Heat, intense physical activity (profuse sweating), diarrhea, vomiting, and excessive urination can all cause excessive fluid loss. A runner can sweat off six cups of fluid in an hour. Mild dehydration occurs with a loss of 5 percent or less of a person's bodily fluids, moderate dehydration is a loss of 5 to 10 percent of a person's bodily fluids, and severe dehydration is a loss of 10 to 15 percent of fluids. Severe dehydration can cause death. Some clinical signs of dehydration include dry skin, less frequent urination, fatigue, light-headedness, dark-colored urine, dry mouth, and lack of skin elasticity. Often, increased fluid intake and replacement of lost electrolytes are sufficient oral rehydration therapy for mild dehydration. However, the cause of dehydration has to be addressed for further improvement. In cases of severe dehydration, it may be necessary to hospitalize the person and restore fluid balance through intravenous fluid replacement.

04/22/23 Prof. Giancarlo Pantaleoni : Farmacologo- Idroclimatologo

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Water Excretion RegulationThe brain and kidneys regulate the amount of water excreted by the body. When the blood volume is low, the concentration of solutes in the blood is high. The brain responds to this situation by stimulating the pituitary gland to release an antidiuretic hormone (ADH), which signals the kidneys to reabsorb and recirculate water. When the individual needs more water, the kidneys will excrete less and even reabsorb some.When excessive fluid loss occurs, the blood volume will fall, as will blood pressure. The kidneys respond by secreting an enzyme called rennin. Rennin activates the blood protein angiotensinogen to convert to angiotensin, which causes the blood vessels to constrict and blood pressure to rise. Angiotensin also activates the adrenal glands to release a hormone called aldosterone. Aldosterone causes the kidneys to retain sodium and water. When the body needs water, less is excreted and more is retained.

Water IntoxicationWater intoxication occurs when there is too much fluid in the body. Excess fluid may collect in bodily tissue, particularly in the feet and legs, a condition called edema. Excess consumption of fluids, as well as kidney disorders that reduce urine output, may contribute to water intoxication. The symptoms of water intoxication are confusion, convulsions, and, in extreme cases, death.DEHYDRATION; DIARRHEA; NUTRIENTS; ORAL REHYDRATION THERAPY. from Kweethai C. Neill

04/22/23 Prof. Giancarlo Pantaleoni : Farmacologo- Idroclimatologo

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B) Funzioni dell’acqua intracellulare ed extracellulare

Recenti acquisizioni sulla regolazione dell’Acqua intracellulare

The Nobel Prize in Chemistry 2003

The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Chemistry for 2003 "for discoveries concerning channels in cell membranes", with one half of the prize to

1. Peter Agre "for the discovery of water channels" and2. one half of the prize to Roderick MacKinnon "for structural

and mechanistic studies of ion channels".

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  Salt and water are important actors in the chemistry of life. Life on earth, and our own lives, originated in salt water – in the oceans and in the womb (= grembo materno). Yet only fairly recently have we understood how water molecules and salt ions are transported in and out through the cell walls.    

        

     

        

      

Peter Agre

Roderick MacKinnon

Peter Agre Roderick MacKinnon

04/22/23 Prof. Giancarlo Pantaleoni : Farmacologo- Idroclimatologo

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The Art of Water Transport in Aquaporins

Aquaporins are membrane water channels that play critical roles in controlling the water contents of cells. These channels are widely distributed in all kingdoms of life, including bacteria, plants, and mammals.

More than ten different aquaporins have been found in human body, and several diseases, such as congenital cataracts and nephrogenic diabetes insipidus, are connected to the impaired function of these channels.

They form tetramers in the cell membrane, and facilitate the transport of water and, in some cases, other small solutes across the membrane.

However, the water pores are completely impermeable to charged species, such as protons, a remarkable property that is critical for the conservation of membrane's electrochemical potential, but paradoxical at the same time, since protons can usually be transfered readily through water molecules.

04/22/23 Prof. Giancarlo Pantaleoni : Farmacologo- Idroclimatologo

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04/22/23 Prof. Giancarlo Pantaleoni : Farmacologo- Idroclimatologo

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Major Sites of Expression Comments to the Functions

Aquaporin-0 Eye: lens fiber cells Fluid balance within the lens

Aquaporin-1

Red blood cells Osmotic protection

Kidney: proximal tubule Concentration of urine

Eye: ciliary epithelium Production of aqueous humor

Brain: choriod plexus Production of cerebrospinal fluid

Lung: alveolar epithelial cells Alveolar hydration state

Aquaporin-2 Kidney: collecting ducts Mediates antidiuretic hormone activity

Aquaporin-3 *Kidney: collecting ducts Reabsorbtion of water into blood

Trachea: epithelial cells Secretion of water into trachea

Aquaporin-4

Kidney: collecting ducts Reabsorbtion of water

Brain: ependymal cells CSF fluid balance

Brain: hypothalamus Osmosensing function?

Lung: bronchial epithelium Bronchial fluid secretion

Aquaporin-5Salivary glands Production of saliva

Lacrimal glands Production of tears

Aquaporin-6 Kidney Very low water permeability; function?

Aquaporin-7 * Testis and sperm

Aquaporin-8 Testis, pancreas, liver, others

Aquaporin-9 * Leukocytes

* an aquaglyceroporin

04/22/23 Prof. Giancarlo Pantaleoni : Farmacologo- Idroclimatologo

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Conclusioni

Studiare ed approfondire a livello Microdialitico:

La Collaborazione peptidica e neuroumorale tra cellule-apparati ed organi (ne sono già state scoperte alcune: fattore natriuretico, ormoni, neuromediatori, ecc.ecc.)

Attendiamo fondi per:

1

2 Produrre tecnologie e Metodi per monitorare e Controllare l’inquinamento delle acque alimentari e d’irrigazione ( abbiamo presentato qui un Metodo illustrato dall’ ING. Antonio PACILÈ e presentato per i Fondi EUROPEI)

3 Scoprire e Classificare Farmacotossicologicamente ogni sostanza naturale Vegetale ed animale per una Banca dati internazionale.

Noi abbiamo messo a punto un Metodo di base che produce il risparmio per la sperimentazione del 90% degli animali di Laboratorio e di sostanze da testare.

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Grazie per l’attenzione! Attendiamo Fondi = MONETE per la Ricerca Scientifica!..a proposito…una scoperta curiosa!!!

180 avanti Cristo I° Moneta conosciuta in NICKEL-RAME di King Pantaleon ”the Savior”.

Moneta Europea in Nickel-Rame

Valore= 1936,27 Lire Italiane

Classe 1936

04/22/23 Prof. Giancarlo Pantaleoni : Farmacologo- Idroclimatologo

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Eccoci qui… tutti insieme!!!... Quanta acqua…!!!

Questa conferenza è riportata nel mio sito:

www.fasam.it

Fasam = farmaci-salute-ambiente

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Water Structure and BehaviorMartin Chaplin Liquid water (H2O) is often perceived to be pretty ordinary as it is transparent, odorless, tasteless and ubiquitous. It is the simplest compound of the two most common reactive elements in the Universe. However, it is the most remarkable substance. Although we drink it, wash, fish and swim in it, and cook with it (although probably not all at the same time), we nearly always overlook the special relationship it has with our lives. Droughts cause famines and floods cause death and disease. We are about two-thirds water and, without it, we die within a few days. It has importance as a structured and structuring solvent, a solute, a reactant and a biomolecule. Life cannot evolve or continue without liquid water, which is why there is so much fuss about water being found on Mars and other planets and moons. Water is the second most common molecule in the Universe (behind hydrogen, H2) and is fundamental to star formation. It is unsurprising that it plays a central role in many of the World's religions. Because of its clear importance, water is the most studied material on Earth but it comes as a surprise to find that its behavior and function are so poorly understood (or even ignored), not only by people in general, but also by scientists working with it everyday.Water seems, at first sight, to be a very simple molecule, consisting of just two hydrogen atoms attached to an oxygen atom. Indeed, there are very few molecules that are smaller or lighter.

Ulteriori approfondimenti in Internet per gli studenti:

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The size of the water molecule, however, belies the complexity of its actions and its singular capabilities. Water's unique properties seem to fit ideally into the requirements for life as can no other molecule.A number of explanations of the complex behavior of liquid water have been published, many quite recently, with several stirring up great controversy. In this site, I have attempted to present these ideas in a self-consistent manner, which I hope will encourage both its understanding and further work. The water molecule The structure of the water molecule (easier introduction, water's molecular orbitals) Molecular vibration and absorption of water Hydrogen bonding in water (easier introduction, the molecular orbitals of a water dimer and cyclic pentamer) The Phase Diagram of water Hexagonal ice, Cubic ice, Ice-two, Ice-three, Ice-four, Ice-five, Ice-six, Ice-seven, Ice-eight, Ice-nine, Ice-ten, Ice-eleven, Ice-twelve, Ice-thirteen, Ice-fourteen, Clathrate ices I, II and H, Amorphous ice Water ionization (the molecular orbitals of the H3O+ and OH- ions, H3O2+ ion and H5O2+ ions) Forty-one anomalies of water and their explanations

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Weird properties of water Vapor pressure-Temperature behavior, Pressure-Temperature-Density behavior Volume-Temperature behavior, Temperature-viscosity behavior Properties of water and heavy water (changes with temperature) Molecular models of water Water clustering in liquid water Overview of the structuring in liquid water (outline of methods for investigating water structure) Introduction to water clustering (a brief history of water clusters) The icosahedral (H2O)280 water clusters The tetrahedral (H2O)14 water cluster Water icosahedral cluster architecture (spherical coordinates, shell radii/occupancy, alternatives) Differences in icosahedral water structures on puckering Water cluster equilibria, puckering and temperature effects (explanation using animated gifs) Connectivity map for the icosahedral water cluster Supercluster of 13 icosahedral water clusters (superstrand of water icosahedral clusters) Substructural forms of the icosahedral water cluster Alternative clusters and water cluster architecture, based on gas clathrates

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Paper model Evidence for icosahedral water clusters Conclusions Hydration Hydrocolloids Agar, Alginate, Arabinoxylan, Carrageenan, CMC, Cellulose, Curdlan, Gelatin Gellan, b-Glucan, Gum arabic, Guar gum, Locust bean gum, Pectin, Starch, Xanthan gum Hydrocolloid rheology Hydrocolloids and health Ions and the Hofmeister series H3O+ magic number cluster ion, SO42- cluster, tetramethylammonium ion clustering, CO2 cluster Hydrophobic hydration Kosmotropes and chaotropes Sugar hydration (cyclodextrins) Polysaccharide hydration (introduction to polysaccharides, furan pseudorotational angles) Protein hydration and denaturation Intracellular water Nucleic acid hydration Aqueous biphasic systems

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Aqueous solutions of C60 Magnetic and electric effects on water Water and microwave radiation (background information, complex dielectric permittivity) Water activity Water and health Frequently asked questions concerning liquid water How can hot water freeze quicker than cold water? Can water be prevented from freezing by increasing the pressure? Is water good for you? Is water blue? Does water have a memory? Does magnetic descaling of water work? How can a liquid have a structure? Does the radial distribution peak at about 3.7 Å exist? Is there fine structure in the radial distribution function? Do interstitial water molecules exist? How is icosahedral clustering related to the outer structure two-state mixture model?

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Water-related material Homeopathy, including a working hypothesis of the dilution effect. Declustered water, anomalous water and polywater Novel fulleranes Platonic solids and water Extras Contributed papers J. G. Watterson, Enzyme function: random events or coherent action? Philippa Wiggins, Life depends upon two kinds of water Book reviews Aqueous systems at elevated temperatures and pressures Handbook of refractive index and dispersion of water for scientists and engineers References 1 - 100, 101 - 200, 201 - 300, 301 - 400, 401 - 500, 501 - 600, 601 - 700, 701 - 800, 801 - 900, 901 - 1000, 1001 ® Visitor's Book (post your news and views, Visitor's Book archive 2000-2003) Site news Water related links