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The Evolving Role of theEnvironmental Manager at

Genzyme Corporationfrom Compliance to Sustainability

Joan BoegelAssociate Director, Environmental Affairs

Genzyme CorporationMarch 18, 2005

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Outline

About Genzyme

Environmental Department

Changes since 2000 Business Tools for Environmental

Management

Key Priorities Future Opportunities

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Genzyme Corporation

One of the worlds foremostbiotechnology companies

Founded in Boston in 1981

Dedicated to making positiveimpact on lives of patientswith serious diseases

Products and Services focusedon Rare inherited diseases

Kidney disease Orthopedics Transplant / immune diseases Cancer Genetics / Diagnostics

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Genzyme - Global and Growing

7,000 employees in 29 countries(Up from 4,434 in 2000)

Serving patients in more than 80 countries

14 manufacturing sites 9 genetic testing lab sites

More than 25 marketed products and

services

2004 revenues of $2.2 billion(Up from $0.9 billion in 2000)

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Genzymes Corporate

Environmental CommitmentGenzyme Corporation will conduct its

businesses in a safe andenvironmentallyresponsible manner in compliance with allhealth, safety and environmental regulations.

Genzyme will operate its facilities so as toprotect our environment and conserve ournatural resources, making our corporate andresidential neighbors proud to have Genzyme intheir communities. Genzyme managers will

provide leadership to achieve these goalsthrough their plans and operations and allemployees will incorporate these goals andpractices into their daily operations."

Henri A. Termeer

President andCEO

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Genzyme CenterCambridge, MA

Green Building symbolic of Genzymescommitment to the environment, thecommunity and employees

Reflective of Genzymes core values

Environmentally responsible andenergy-efficient

INNOVATION

COLLABORATION

TRANSPARENCY

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Genzymes Environmental

DepartmentOur mission is to ensure compliance with environmental

regulations and to promote pollution prevention andenvironmental stewardship at Genzyme facilities worldwide.

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Organization Structure

CEO

Sr. VP Operations

VP, Engineering & Facilities Planning, HS&E

Director, Environmental Affairs

Environmental Operations Group

(Massachusetts)

Director, Occupational Health and Safety

Corporate Environmental Group Lab Support Services

Outside MASite Environmental

Professionals

HSE Sr. SteeringCommittee

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Genzyme - Massachusetts

14 Sites in Cambridge,Allston, Framingham &Westborough

Manufacturing 6 sites

Therapeutics, Diagnostics,BioSurgery

Research 4 GenzymeScience laboratorybuildings

QC Laboratories

Clinical Laboratory Genzyme Genetics

4 Office-only buildings

1.5 million sq. ft.

>3,000 employees

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Changes since 2000

GENZYME

Growth Acquisitions

New facility construction /renovation

Old facility shutdown / closure /moves

New processes and operations

New employees

EXTERNAL

New Environmental ComplianceRequirements

More information available on-line

More electronic reporting

Environmental Agency (DEP, MWRA)staff and budget cuts

Business Trends EnvironmentalManagement Systems, Sustainability

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Changes since 2000

Introduction ofGEMSGenzymeEnvironmental Management System

Construction and opening ofGenzyme Center Green Building

Expansion of Beyond Complianceinitiatives recycling, stewardshipevents, paper use reduction

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Impact

Workload growing

Scope & variety of jobexpanding

Its not just about COMPLIANCE anymore.

Management andemployee involvement

Recognition / AwardsGenzyme CenterEPA WasteWiseEPA Best Workplaces for

CommutersDow Jones Sustainability

Index

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Genzyme Environmental Management System

GEMS is:A cycle of planning, implementing,reviewing and improving the actionsthat Genzyme takes to address itsimpacts on the environment. Modeled on ISO 14001

Supported by senior management Flexible and integrated into each sitesoperations

Goals

Compliance with applicable

regulations Continual improvement of

Genzymes environmentalperformance

Plan

Do

Check

Act

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GEMS - Business Tools for

Environmental Management

POLICYSite Environmental Management Policy

KNOWLEDGE & TRAININGEnvironmental awareness training

MONITORING & MEASUREMENTKey Environmental Performance Indicators (KEPIs)

INTERNAL COMMUNICATION Reports Quarterly & annual Intranet Environmental Website

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Site Environmental Management Policy

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Environmental Awareness TrainingScope All employees office, lab, mfg

Content Site Specific Intro to GEMS, Environmental Dept., compliance requirements,

beyond-compliance programs Links to resources on intranet

Delivery Roll-out by e-mail from Site Management or Committee Computer-based

Self-guided PowerPoint presentation On-line survey tool quiz

Records Employee Learning Management System

Results 70% participation by year-end 2004 overall Strong Site Management or Committee involvement yields best

% completion

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Monitoring and Measurement ofEnvironmental Performance

Compliance

Air Emissions Energy Use

Water Use

Solid Waste

Chemical Waste Stewardship

GEMS identifies seven Key EnvironmentalPerformance Indicators (KEPIs):

These seven indicators are tracked and reported at all

Genzyme sites in order to measure our impact on theenvironment.

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KEPI Success Stories

Measurement & Reporting identifiesopportunities for improvement

Water conservation Landscape irrigation Autoclave steam condensate quench

Air emissions Surface disinfection

Solid Waste / Recycling Better data collection / new recycling programs Paper Reduction double-sided printing, paperless

meetings

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Quarterly Environmental Report

Sent to HSE-SSC in advance of their quarterly meeting Highlights discussed at meeting Shared with site environmental professionals worldwide

Compliance Regulatory non-compliance events Summary of any inspections or audits Permit activity

Success Stories Water Conservation, Energy Savings, Waste Reduction,

Recycling

Stewardship Volunteer events e.g., Charles River clean up Donations

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Annual Environmental PerformanceReports

Contents KEPI data & narrative Progress vs. goals New goals Success stories Green Initiative awards

Audience Genzyme management Genzyme employees

Functions Awareness Comparisons Goals

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Intranet Environmental Web Site

Navigate to your area of interest.

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GEMS Benefits

Proactive Environmental Compliance Assurance

Environmental risks, liabilities, and impacts

minimized Reduced waste generation and costs Reduced energy and water use and costs

Reduced emissions to environment

Positive corporate image with environmentalagencies, the public and employees Recognition as green company biotechnology

industry leader

Employee pride in the organization

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Key Priorities short term

Environmental Performance Reports

On-line service to access regulations and analysis

Voluntary programs EPA Labs 21 for Framingham Science Center

EPA / DEP WasteWise at Cambridge,

Westborough & Framingham

EPA Performance Track

Paper Use Reduction

Documentation QA system

http://www.epa.gov/wastewise/

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Future Opportunities

Innovation Green building Green power Green chemistry

Collaboration Within Genzyme Peer groups Agency partnerships Environmental non-profits Community

TransparencySustainability Reporting to Public

INNOVATION

COLLABORATION

TRANSPARENCY