VII edizione Capri Pediatria Capri, 28 – 30 Aprile 2014 Biomarkers nell’asma bronchiale...
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edizione Capri Pediatria ri, – 30 Aprile 2014 Biomarkers nell’asma bronchial Guglielmo Scala Napoli
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Transcript of VII edizione Capri Pediatria Capri, 28 – 30 Aprile 2014 Biomarkers nell’asma bronchiale...
VII edizione Capri PediatriaCapri,28 – 30 Aprile 2014
Biomarkers nell’asma bronchiale
Guglielmo ScalaNapoli
Pathogenesis of AsthmaHolgate S, Clin Exp Allergy, 2008
Pathogenesis of AsthmaHolgate S, Clin Exp Allergy, 2008
La cellula Th2 è fondamentale per la maturazione dell’eosinofilo
Pathogenesis of AsthmaHolgate S, Clin Exp Allergy, 2008
A new look at the pathogenesis of asthmaHolgate ST, 2010, Clinical Science
A new look at the pathogenesis of asthmaHolgate ST, 2010, Clinical Science
Pathogenesis of AsthmaHolgate S, Clin Exp Allergy, 2008 Nasce il
concetto di EMTU
Lamina basale è prodotta dalle cell epiteliali
Lamina reticolare (MBR) è prodotta dai fibroblasti
A new look at the pathogenesis of asthmaHolgate ST, 2010, Clinical Science
Viral infections and atopy in asthma pathogenesis: new rationales for asthma prevention and treatmentP. Holt & P. Sly, Nature Medicine, 2012
Holt & Sly, Nat Med 2012
Holt & Sly, Nat Med 2012
Holt & Sly, Nat Med 2012
Holt & Sly, Nat Med 2012
Holt & Sly, Nat Med 2012Smascherata la marcia atopica??
The basics of epithelial-mesenchymal transitionKalluri R, Weinbergjj R , J Clin Invest. 2009.
The basics of epithelial-mesenchymal transitionKalluri R, Weinbergjj R , J Clin Invest. 2009.
A clinical pharmacological study of the potential beneficial effects of a propolis food product as an adjuvant in asthmatic patients.
Khayyal MT 2003, Fundam Clin Pharmacol
FVC + 19%
FEV1 +30%
PEFR +30%
FEF 25-75 +41%
TNF -52%
ICAM-1 -65%
IL-6 -44%
IL-8 -30%
IL-10 +300%
Asma notturno/settimana - 60 %
22 pazienti : placebo24 pazienti : propoli
Brazilian Green Propolis: Anti-Inflammatory Property by an Immunomodulatory Activity Machado JL et al, 2012, Evidence-Based Compl Altern Med
Caffeic acid phenethyl ester inhibits nuclear factor-kB and protein kinase B signalling pathways and induces caspase-3 expression in primary human CD4+ T cells
Wang et al, 2009, Clin Exp Immunol
The inhibitory effect of CAPE results in the inhibition of cytokine production and proliferation in primary human CD4+ T cells
Caffeic Acid Phenethyl Ester and Its Amide Analogue Are Potent Inhibitors of Leukotriene Biosynthesis in Human Polymorphonuclear Leukocytes. Boudreau L, 2012, PlosOne
Caffeic Acid Phenethyl Ester and Its Amide Analogue Are Potent Inhibitors of Leukotriene Biosynthesis in Human Polymorphonuclear Leukocytes. Boudreau L, 2012, PlosOne
Propolis inhibits TGF-β1-induced epithelial-mesenchymal transition in human alveolar epithelial cells via PPARγ activation. Kao HF, et al. 2013, Int Immunopharmacol
TGF- bAlterazioni morfologiche↓ E - cadherin↑ N - cadherin↑ ROS↑ motilità cellulare
Propolis inhibits TGF-β1-induced epithelial-mesenchymal transition in human alveolar epithelial cells via PPARγ activation.
Kao HF, et al. 2013, Int Immunopharmacol
TGF- bAlterazioni morfologiche↓ E - cadherin↑ N - cadherin↑ ROS↑ motilità cellularePROPOLI
Se pretrattiamo con CAPE (ac. Caffeico) l’effetto è di minore intensità.
Propolis inhibits TGF-β1-induced epithelial-mesenchymal transition in human alveolar epithelial cells via PPARγ activation. Kao HF, et al. 2013, Int Immunopharmacol
The results of this study suggest that natural propolis extracts may prevent TGF-β1-induced EMT in alveolar cells, which may be clinically applied in the prevention and/or treatment of EMT-related fibrotic diseases as well as airway remodeling in chronic asthma
