Skripsi Risca
Transcript of Skripsi Risca
-
7/24/2019 Skripsi Risca
1/52
EFEKTIVITAS SEDIAAN OBAT KUMUR MENGANDUNG
CENGKEH (Syzygium aromaticum) DALAM MENURUNKAN
KADAR VOLATILE SULFUR COMPOUNDS (VSC) KOMPONEN
CYSTEIN (H2S)
SKRIPSI
Diajukan K!a"a Uni#$%i&a% Ha%anu""in
Guna M'nui Saa %a&u S*a$a&
Un&uk M'!$+ Ga$ Sa$jana K"+k&$an Gi,i
DISUSUN OLEH:
RISCA LISAL
J111 11 133
BAGIAN ILMU KESEHATAN GIGI MASYARAKAT
FAKULTAS KEDOKTERAN GIGI
UNIVERSITAS HASANUDDIN
MAKASSAR
2014
LEMBAR PENGESAHAN
-
7/24/2019 Skripsi Risca
2/52
Judul : E!"#$%$#&' S!d$&&( O) Ku*u+ C!(,"!-(Syzygium aromaticum)
D&l&* M!(u+u("&( K&d&+ Volatile Sulfur Compounds (VSC)
".*/.(!( C'#!$(H2S
Ol!- : R$'& L$'&l J 111 11 133
T!l&- D$/!+$"'& d&( D$'&-"&(
5&d& T&(,,&l 16 N.%!*)!+ 2014
Ol!- :
P'-i'-in,
P$+./ D$/ "$,/ Ra%'i"a$ Sa'a"0 MS
NIP/ 1345622 17456 2 551
M!(,!#&-u$7
Dkan Faku&a% K"+k&$an Gi,i
Uni#$%i&a% Ha%anu""in
P$+./ "$,/ H/ Man%ju$ Na%i$0 P/D
NIP/ 1365823 17659 1 551
PERNYATAAN
2
-
7/24/2019 Skripsi Risca
3/52
S&& &(, )!+#&(d& #&(,&( d$)&8&- $($ :
N&*& : R$'& L$'&l
N$* : J 111 11 133
Ad&l&- *&-&'$'8& F&"ul#&' K!d."#!+&( G$,$ U($%!+'$#&' H&'&(udd$( M&"&''&+ &(,
#!l&- *!l&"u"&( /!(!l$#$&( d!(,&( 9udul EFEKTIVITAS SEDIAAN OBAT
KUMUR CENGKEH (Syzygium aromaticum) DALAM MENURUNKAN
KADAR VOLATILE SULFUR COMPOUNDS (VSC) KOMPONEN CYSTEIN
(H2S)d&l&* +&(,"& *!(!l!'&$"&( '#ud$ 5+.,+&* 5!(d$d$"&( S#+& Su
D!(,&( $($ *!(&"&( )&-8& d$d&l&* '"+$/'$ $($ #$d&" #!+d&/ "&+& &(,
/!+(&- d$&9u"&( u(#u" *!*/!+.l!- ,!l&+ "!'&+9&(&&( d$ 'uu 5!+,u+u&( T$(,,$7 d&(
'!/&(9&(, /!(,!#&-u&( '&& 9u,& #$d&" #!+d&/ "&+& &u /!(d&/ &(, /!+(&-
d$#ul$' &u d$#!+)$#"&( .l!- .+&(, l&$(7 "!u&l$ &(, '!&+& #!+#ul$' d$ &u d&l&*
(&'"&- $($ d&( d$'!)u#"&( d&l&* d&+ /u'#&"&
M&"&''&+7 2; N.%!*)!+ 2014
Nu+&!d& A 7SS.'
KATA PENGANTAR
3
-
7/24/2019 Skripsi Risca
4/52
5u9$ d&( 'u"u+ /!(ul$' /&(9"&( "!/&d& Tu-&( &(, M&-& E'& "&+!(&
-&(& d!(,&( )!+" "!"u&(7 "&'$- d&( +&-*
-
7/24/2019 Skripsi Risca
5/52
3 "$,/ Su$ijana Ma!!an,a$a0 S!/P$i+0 M/K% '!l&"u /!(&'!- &"&d!*$"
&(, '!(&(#$&'& *!*)!+$ du"u(,&(7 (&'$- *.#$%&'$ d&( '!*&(,
'!-$(,,& /!(ul$' )!+-&'$l *!(!l!'&$"&( 9!(9&(, /!+"ul$&-&( d!(,&( )&$"
4 O+&(, #u&"u7 Ni;+ Li%ad&( C$i%&ina Buain7 '!+#& '&ud&+&
-
7/24/2019 Skripsi Risca
6/52
? Na$>a%&u (Kak F-*0 S$i&a0 Sa$i0 =&$*;ia0 =in"i0 Nia0 d&( Ran&i) '!+#&
Ha"ija&u d&( G$a;ia/ T!+$*& "&'$- &' "!-&d$+&(7 "!#ulu'&(7 d.&7 )&(#u&(7
'!*&(, *.#$%&'$7 /!+-$&(7 d&( &(d& #&8& &(, '!l&lu "&l$&( )!+$"&(
M!(,!(&l "&l$&( &d&l&- '&l&- 'u -&l &(, /&l$(, $(d&- d&l&* -$du/"u
6 T!*&( '!/!+9u&(,&( Nia Lian&+ d&( T$i%an&+%+ R?"* A%aui0 &(, #!l&-
'&*&
-
7/24/2019 Skripsi Risca
7/52
5!(ul$' )!+-&+&/ "$+&(& Tu-&( )!+"!(&( *!*)&l&' '!,&l& "!)&$"&( d&+$ '!,&l&
/$-&" &(, #!l&- )!+'!d$& *!*)&(#u /!(ul$' A"-$+(& d!(,&( '!,!(&/ "!+!(d&-&(
-$7 /!(ul$' *!(,-&+&/"&( &,&+ "$+&(& #ul$'&( $($ d&/ *!(9&d$ '&l&- 'u )&-&(
/!*)!l&9&+&( d&( /!($(,"&( "u&l$#&' /!(d$d$"&( d$ F&"ul#&' K!d."#!+&( G$,$ "!
d!/&((&7 9u,& d&l&* u'&-& /!($(,"&( /!+)&$"&( "u&l$#&' "!'!-&( G$,$ d&(
Mulu# *&'&+&" A*$(
M&"&''&+7 23 N.%!*)!+ 2014
R$'& L$'&l
EFEKTIVITAS SEDIAAN OBAT KUMUR MENGANDUNG CENGKEH
(Syzygium aromaticum) DALAM MENURUNKAN KADAR VOLATILE
SULFUR COMPOUNDS (VSC) KOMPONEN CYSTEIN (H2S)
R$'& L$'&l
7
-
7/24/2019 Skripsi Risca
8/52
ABSTRAK
B&u *ulu# &u )$&'& d$'!)u# d!(,&( halitosis &d&l&- (&&' #&" '!d&/ &(,
)!+&'&l d&+$ ud&+& &(, d$"!lu&+"&( .l!- '!'!.+&(, l!8 *ulu# d&( 60@(& )!+&'&l
d&+$ +.(,,& *ulu# &(, d$'!)&)"&( .l!- '!(&8& 'ulu+ &(, *ud&- *!(,u&/ &(,
d$'!)u# d!(,&( Volatile Sulfur Compound VSC T!l&- )!+!d&+ .) "u*u+ &(,
*!(,&(du(, !(,"!- "&+!(& .) "u*u+ !(,"!- *!(,&(du(, -&'$l $'.l&'$ d&+$
*$(&" !(,"!- Syzygium aromaticum) &$#u '!(&8& !u,!(.l &(, )!+/!+&(
'!)&,&$ &(#$)&"#!+$ &(, d&/ *!l&8&( )&"#!+$ +.(,,& *ulu# Tujuan !ni&ian$($
u(#u" *!(,!#&-u$ !!"#$%$#&' '!d$&&( .) "u*u+ &(, *!(,&(du(, !(,"!-Syzygium aromaticum d&l&* *!(u+u("&( "&d&+ Volatilesulfur compounds VSC
".*/.(!( -$d+.,!( 'ul$d&H2S 5!(!l$#$&( $($ d$l&"u"&( d$ "l$($" -&l$#.'$' RSGM
U($%!+'$#&' G&d9&- M&d& /&d& S!/#!*)!+
-
7/24/2019 Skripsi Risca
9/52
ABSTRACT
M.u#- .d.+ .+ -&l$#.'$' $' .**.(l &ll!d )&d )+!- +.* #-! &$+ !/!ll!d ) &
/!+'.( #-+.u,- -$' *.u#-7 &(d 60@ &*! +.* #-! .+&l &%$# &u'!d ) %.l$l!
'ulu+ .*/.u(d' &ll!d %.l$l! 'ulu+ .*/.u(d VSC M.u#-8&'- #- .(#&$('
l.%! -&' )!!( $+ul!d (.8&d&'7 $# )!&u'! l.%!' &' & *.u#-8&'- .(#&$($(,
$'.l!d
-
7/24/2019 Skripsi Risca
10/52
LEMBAR PENGESAHAN ///////////////////////////////////////////////////////////////////////// ii
PERNYATAAN //////////////////////////////////////////////////////////////////////////////////////////// iii
KATA PENGANTAR ///////////////////////////////////////////////////////////////////////////////// i#
ABSTRAK //////////////////////////////////////////////////////////////////////////////////////////////////// #iii
DAFTAR ISI/////////////////////////////////////////////////////////////////////////////////////////////////
DAFTAR TABEL////////////////////////////////////////////////////////////////////////////////////////// i#
DAFTAR GAMBAR///////////////////////////////////////////////////////////////////////////////////// #
BAB I PENDAHULUAN
11 LATAR BELAKANG 1
12 RUMUSAN MASALAH 2
13 TUJUAN 5ENELITIAN 3
131 Tu9u&( U*u* 3
132 Tu9u&( K-u'u' 3
14HI5OTESIS 5ENELITIAN 3
BAB II TINAUAN PUSTAKA
21 HALITOSIS 4
10
-
7/24/2019 Skripsi Risca
11/52
211 E#$.l.,$ H&l$#.'$' 4
212 Kl&'$$"&'$ H&l$#.'$' =
213 M!"&($'*! H&l$#.'$' ?
22 CENGKEH 6
221 K&(du(,&( K$*$& 5&d& C!(,"!- 6
222 M&(& C!(,"!- 10
23 OBAT KUMUR 13
231 A"#$ D&l&* O) Ku*u+ 13
24 HUBUNGAN HALITOSIS DAN CENGKEH 1;
BAB III KERANGKA KONSEP
31 KERANGKA KONSE5 1
32 VARIABEL 5ENELITIAN 1?
33 KETERBATASAN 5ENELITIAN 1?
BAB IV METODE PENELITIAN
41 JENIS 5ENELITIAN 16
42 LOKASI 5ENELITIAN 16
11
-
7/24/2019 Skripsi Risca
12/52
43 AKTU 5ENELITIAN 16
44 5O5ULASI SAM5EL 5ENELITIAN 16
4; METODE 5ENGAMBILAN SAM5EL 20
4= VARIABEL 5ENELITIAN 20
4 DEFINISI O5ERASIONAL 20
4? KRITERIA 5ENILAIAN 20
46 ALAT BAHAN 21
461 Al 21
462 B&-&( 21
410 5ROSEDUR 5ENELITIAN 21
4101 5!(,&*)$l&( S&*/!l 21
4102 5+.'!' 5!(,u9$&( D!(,&( O+&l-+.*& F$' I( 22
4103 K!l&$"&( E#$" 5!(!l$#$&( 22
411 DATA 23
412 ALUR 5ENELITIAN 24
BAB V HASIL PENELITIAN//////////////////////////////////////////////////////////////// 23
12
-
7/24/2019 Skripsi Risca
13/52
BAB V1 PEMBAHASAN/////////////////////////////////////////////////////////////////////// 91
BAB VII PENUTUP
1 SIM5ULAN 3=
2 SARAN 3=
DAFTAR PUSTAKA//////// 94
DAFTAR TABEL
T&)!l ;1 D$'#+$)u'$ "&+&"#!+$'#$" '&*/!l /!(!l$#$&( 2;
T&)!l ;2 D$'#+$)u'$ "&d&+ +&
-
7/24/2019 Skripsi Risca
14/52
"u*u+ !(,"!- )!+d&'&+"&( u'$& '&*/!l 2=
T&)!l ;3 5!+)!d&&( "&d&+ -$d+.,!( 'ul$d& H2S d&( *!#-$l*!+&/#&(
CH3SH '!)!lu* (pretest)d&( '!'ud&- $(#!+%!('$ (posttest)
)!+"u*u+ .) "u*u+ !(,"!- 26
T&)!l ;4 5!+)!d&&( "&d&+ Volatile Sulfur CompoundVSC '!)!lu*
(pretest)d&( '!'ud&- $(#!+%!('$ (posttest))!+"u*u+ .)
"u*u+ !(,"!- 30
DAFTAR GAMBAR
G&*)&+ 41 Alu+ 5!(!l$#$&( 24
G&*)&+ ;1 5+.'!' /!(,&*)$l&( '&*/!l d."u*!(#&'$
/+$)&d$ 2=
14
-
7/24/2019 Skripsi Risca
15/52
G&*)&+ ;2 5+.'!' )!+"u*u+ .) "u*u+ !(,"!- d."u*!(#&'$
/+$)&d$ 2
G&*)&+ ;3 I(9!"'$ '&*/!l "! $(l!# oralchromad."u*!(#&'$
/+$)&d$ 26
BAB I
PENDAHULUAN
1/1/ LATAR BELAKANG
B&u *ulu# &u )$&'& d$'!)u# d!(,&( halitosis &d&l&- (&&' #&" '!d&/ &(,
)!+&'&l d&+$ ud&+& &(, d$"!lu&+"&( .l!- '!'!.+&(, l!8 *ulu# d&( *!(u+u# '#ud$
d&+$ /&+& &-l$ d$ A*!+$"& S!+$" 60@(& )!+&'&l d&+$ +.(,,& *ulu# &(,
d$'!)&)"&( .l!- '!(&8& 'ulu+ &(, *ud&- *!(,u&/ &(, d$'!)u# d!(,&( Volatile
Sulfur Compound VSC Volatile sulfur compounds &d&l&- -&'$l /+.du"'$ d&+$
&"#$$#&' )&"#!+$ &(&!+.) d$ d&l&* *ulu# &(, *!(,-&'$l"&( '!(&8& )!+u/& 'ulu+
&(, *ud&- *!(,u&/ d&( )!+)&u #$d&" !(&" 5+.'!' #!+9&d$(& VSC &d&l&- d$&8&l$
d!(,&( /!*!&-&( 'u)'#+ /+.#!$( d&+$ '$'& *&"&(&( .l!- )&"#!+$ ,+&* (!,$ &(,
)!+'$ /+.#!.l$#$" *!(9&d$ +&(#&$ /!/#$d& d&( &'&* &*$(. '!/!+#$ *!#-$.($(7
'#!$(! d&( '#$(!1K!*ud$&( &'&* &*$(. #!+'!)u# &"&( d$+!du"'$ *!(9&d$ *!#-$l
*!+&/#&(7 -$d+.,!( 'ul$d& d&(
d$*!#-$l 'ul$d& revotella intermedia7 revotella nigrescens d&( !reponema
denticola )!+".+!l&'$ d!(,&( "&d&+ -$d+.,!( 'ul$d& orphyromonas gingivalis7
.intermedia7 d&( !annerella forsythensis)!+".+!l&'$ d!(,&( "&d&+ *!#$l *!+"&/#&(
S!l&(9u#(&7 *!#$l *!+"&/#&( *!+u/&"&( /!(!)&) u#&*& -&l$#.'$' d$)&(d$(,"&(
15
-
7/24/2019 Skripsi Risca
16/52
-$d+.,!( 'ul$d& d&( d$*!#$l'ul$d& d$*&(& *!#$l *!+"&/#&( d&( -$d+.,!( 'ul$d&
)!+&'&l d&+$ $(#+&.+&l7 '!d&(,"&( d$*!#$l'ul$d& d$du,& )!+&'&l d&+$ !"'#+&.+&l2
B&-&( &(#$*$"+.)& &(, '!+$(, d$,u(&"&( d&l&* "!-$du/&( '!-&+$
-
7/24/2019 Skripsi Risca
17/52
2 A/&"&- '!d$&&( .) "u*u+ &(, *!(,&(du(, !(,"!- Syzygium
Aromaticum d&/ *!(u+u("&( "&d&+ Volatilesulfur compounds VSC
".*/.(!( *!#-$.($( CH3SH
1/9/ TUUAN PENELITIAN
1/1/1/ Tujuan U'u'
U(#u" *!(,!#&-u$ !!"#$%$#&' '!d$&&( .) "u*u+ &(, *!(,&(du(,
!(,"!- Syzygium Aromaticum d&l&* *!(u+u("&( "&d&+ Volatile
sulfur compounds VSC
1/1/2/ Tujuan Ku%u%
1 U(#u" *!(,!#&-u$ !!"#$%$#&' '!d$&&( .) "u*u+ &(,
*!(,&(du(, !(,"!- Syzygium Aromaticum d&l&* *!(u+u("&(
"&d&+ Volatilesulfur compounds VSC ".*/.(!( '#!$(! H2S
2 U(#u" *!(,!#&-u$ !!"#$%$#&' '!d$&&( .) "u*u+ &(,
*!(,&(du(, !(,"!- Syzygium Aromaticum d&l&* *!(u+u("&(
"&d&+ Volatilesulfur compounds VSC ".*/.(!( *!#-$.($(!
CH3SH
1/6/ HIPOTESIS PENELITIAN
3
-
7/24/2019 Skripsi Risca
18/52
1 S!d$&&( .) "u*u+ &(, *!(,&(du(, !(,"!- Syzygium Aromaticum
d&/ *!(u+u("&( "&d&+ Volatile sulfur compounds VSC ".*/.(!(
'#!$(! H2S
2 S!d$&&( .) "u*u+ &(, *!(,&(du(, !(,"!- Syzygium Aromaticum
d&/ *!(u+u("&( "&d&+ Volatile sulfur compounds VSC ".*/.(!(
*!#-$.($(! CH3SH
BAB II
TINAUAN PUSTAKA
2/1/ HALITOSIS
H&l$#.'$' &d&l&- )&u (&&' #&" '!d&/ &(, "!lu&+ d&+$ +.(,,& *ulu# S&*/&$ '&
$($7 -&l$#.'$' *!+u/&"&( '&l&- 'u *&'&l&- "!'!-&( *ulu# &(, )&(&" d$"!lu-"&(
*&'&+&" '!#!l&- "&+$!' d&( /!(&"$# /!+$.d.(#&l4
2/1/1/ E&i++,i Hai&+%i%
H&l$#.'$' d&/ d$'!)&)"&( .l!- )!)!+&/& &"#.+7 &(#&+& l&$( :
& F$'$.l.,$'
5!(u+u(&( &l$+&( '&l$%& '& #$du+ *!+u/&"&( '&l&- 'u /!(!)&)
-&l$#.'$'
Fu(,'$ u#&*& d&+$ '&l$%& &d&l&- '!)&,&$ &(#$)&"#!+$7 *!(,&(,"u# ."'$,!( "!
d&l&* +.(,,& *ulu#7 #+&('/.+# !($* '!/!+#$ &*l&'! d&( u(#u" *!('#&)$l"&(
4
-
7/24/2019 Skripsi Risca
19/52
/H d&l&* *ulu#;
) 5.l.,$'
1 5!(!)&) I(#+&.+&l
& G$,$
D$'!)&)"&( .l!- ,$,$ ,!l$,$ "&+!(& &d&(& l!'$ "&+$!' &(,
d&l&* d!(,&( $*/&"'$ *&"&(&(7 lu"& !"'#+&"'$ d!(,&(
,u*/&l&( d&+&- G$,$ /&l'u &"+$l$"7 #!+u#&*& "!#$"& d$/&"&$
'& #$du+ d&( #$d&" #!+u+ d$)!+'$-"&(7 9u,& d&/
*!(,-&'$l"&( )&u *ulu# &(, d$'!)&)"&( .l!- &(d$d$&'$'=
) I(!"'$ 5!+$.d.(#&l
B!+d&'&+"&( )!)!+&/& /!(!l$#$&( *!(u(9u""&( )&-8&
/!(&"$# /!+$.d.(#&l *!(!)&)"&( )&u #$d&" '!d&/ K.('#+&'$
VSC &(, #$(,,$ d$d&/"&( /&d& /!(d!+$#& /!(&"$#
/!+$.d.(#&l T.(!(#$-= *!(u9u""&( )&-8& ".('#+&'$ d&+$
VSC /&d& (&&' d&+$ *ulu# *!($(," d!(,&( &d&(& /."!#
d&l&*7 VSC d$#!*u"&( l!)$- )&(&" /&d& /&'$!( d!(,&(
/+.)$(, '!)!'&+ 4 ** &u l!)$- d&+$/&d& /&'$!( d!(,&(
"!d&l&*&( /."!# "u+&(, d&+$ 4 **=
M$"+.l.+&
B&"#!+$ &(, *!(!)&)"&( )&u *ulu#7 &d&l&-
Fuso#acterium nucleatum$ revotella intermedia$ d&(
!annerella forsythensis B&"#!+$ l&$( &(, #!l&- #!+l$) d&l&*
5
-
7/24/2019 Skripsi Risca
20/52
/+.du"'$ '!(&8& 'ulu+ %.l$l #!+*&'u" rophyromonas
gingivalis$ orphyromonas endodontalis$ !reponema
denticola$ Aggregati#acter actinomycetemcomitans$
Atopo#ium parvulum$ Campylo#acter rectus$ %esulfovi#rio
spesies$ "i&enella corrodens$ "u#acterium sulci$ Spesies
Fuso#acterium dan eptostreptococcus micros B&"#!+$