F O R M A T O E U R O P E O P E R I L C U R R I C U L U M

V I T A E

INFORMAZIONI PERSONALI Nome e cognome: Eduardo Nobile-Orazio Luogo di nascita: Bologna Data di nascita: 26 settembre 1953 Cittadinanza: Italiana Domicilio: Milano, Via De Albertis 11, 20129. Tel. 0270124894 Posizione ricoperta: Professore Associato Confermato Neurologia, Dipartimento di

Biotecnologie Mediche e Medicina Traslazionale, Università Milano Responsabile, Servizio Autonomo di Malattie Neuromuscolari e

Neuroimmunologia, IRCCS Istituto Clinico Humanitas Indirizzo di lavoro: Via Manzoni 56, 20089 Rozzano (Milano). Tel. 02-8224.2209; FAX. 02-8224.2298 e-mail:eduardo.nobile@unimi.it;

eduardo.nobile_orazio@humanitas.it Stato Civile: Coniugato (Beatrice Aliverti) Codice Fiscale: NBLDRD53P26A944F Lingue: Inglese e Francese, fluente, parlato e scritto

ISTRUZIONE E FORMAZIONE

13/7/1978 Laurea in Medicina e Chirurgia (110/110 e lode) Universita' degli Studi, Milano.

9/11/1982 Specializzazione in Neurologia (70/70 e lode) Universita' degli Studi, Milano.

5/10/1987 Dottorato di Ricerca in Scienze Neurologiche Universita' degli Studi, Milano.

ESPERIENZA LAVORATIVA 17/7/1978-28/2/1982 Medico Interno, Specializzando in Neurologia, Ist. Clinica

Neurologica, Università degli Studi, Milano 1/3/1982-30/6/1984 "Visiting Fellow", Dip. di Neurologia, Columbia University, New

York, N.Y., USA 1/7/1983-30/6/1984 "Post-doctoral Research Fellow", National Multiple Sclerosis

Society, USA 1/11/1983-31/10/1986 Borsista dell'Università di Milano, Dottorato di Ricerca in

Scienze Neurologiche 15/7/1987-29/1/1993 Assistente Medico Neurologo, Ospedale Maggiore Policlinico di

Milano, Ist. Clinica Neurologica, (dal 1/9/1987 a tempo pieno dal 19/7/1988 di ruolo).

29/1/1993- 30/09/2001 Aiuto Corresponsabile Neurologo (poi Dirigente di I Livello, fascia A) a tempo pieno, Ospedale Maggiore Policlinico di Milano, Ist. Clinica Neurologica.

1/7/1997-30/09/2001 Dirigente organizzativo del Servizio di Neuroimmunologia e Diagnostica Neurologica, Ospedale Maggiore Policlinico Milano, Ist. Clinica Neurologica,

01/10/01-30/05/2004 Professore Associato di Neurologia- Dirigente medico I° livello Unità di Neurologia, IRCCS Ospedale Maggiore Policlinico di Milano Policlinico di Milano,

01/06/2004- tuttora Professore Associato di Neurologia - Responsabile di Neurologia II poi del Servizio Autonomo Malattie Neuromuscolari e Neuroimmunologia, Istituto Clinico Humanitas, Rozzano( Milano) 01/06/2004-31/5/2015 Responsabile Neurologia 2, Istituto Clinico Humanitas, Rozzano

(Milano), 01/06/2015- tuttora Responsabile Servizio Autonomo Malattie Neuromuscolari e

Neuroimmunologia, Istituto Clinico Humanitas, Rozzano (Milano) 03/02/2014 Abilitazione Scientifica Nazionale a Professore di Prima Fascia Med 26, Neurologia

ATTIVITÀ DIDATTICA 1988/89-2000/01 Professore a contratto di Neuroimmunologia Clinica Scuola di

Specializzazione in Neurologia Universita' Studi di Milano. 01/10/01- Professore Associato di Neurologia (MED/26) Dip. Scienze

Neurologiche, Università degli Studi di Milano 04/11/02- Visiting Professor, University of Belgrade, School of Medicine,

Yugoslavia

ARTICOLAZIONE ATTIVITÀ DIDATTICA PRESSO L’UNIVERSITÀ DI MILANO 2001- Docente Corso Neuroimmunologia, Scuola Specializzazione Neurologia 2009- Docente Corso Neuroimmunologia, Scuola Specializzazion

Immunologia 2009-2015 Docente Corso di Neurologia, Scuola di Specializzazione di

Radiodiagnostica e in Radioterapia 2002-2012 Docente Responsabile, Corso Neurologia, Corso di Laurea di Logopedia 2001- Docente, Corso integrato, Malattie del del Sistema Nervoso, Corso di

Laurea di Medicina e Chirurgia, Linea C e H 2004-2014 Docente Responsabile, Corso di Neurologia, Laurea di Medicina e

Chirurgia presso il polo didattico dell’Istituto Clinico Humanitas 2004-2016 Docente Responsabile, Corso Basi Patologiche Malattie Neurologiche e

psichiatriche, Laurea Specialistica Biotecnologie Mediche e Medicina Molecolare,

2014- Docente Responsabile, Corso Clinical Neuroscience, Laurea di Medicina e Chirurgia presso il polo didattico dell’Istituto Clinico Humanitas

2016- Docente Responsabile, Corso Pathogenetic bases of Neurological and Psychiatric Disorders, Master Degree Medical Biotechnology and Molecular Medicine

2018- Docente Responsabile, Corso Neuroscience, International Medical School

ATTIVITÀ GESTIONALE PRESSO L’UNIVERSITÀ DI MILANO 2002-2008 Segretario della Scuola di Specializzazione di Neurologia Università

di Milano 01/10/2012- Membro del Comitato di Direzione, Medicina e Chirurgia, Università

di Milano 01/10/2014 Menbro della Giunta del Dipartimento di Biotecnologie Mediche e

Medicina Traslazionale, Università di Milano,

ATTIVITÀ SCIENTIFICA Pubblicazioni 772 pubblicazioni di interesse neurologico (allegato A per articoli e capitoli) di cui: 228 articoli (226 in inglese) di cui 220 con Impact Factor (IF totale 2016: 1278,146) Totale Citazioni: 8427; H index: 52+1 RMC Trial (80 citazioni) 24 capitoli o relazioni in esteso pubblicate su libri di cui 16 in inglese; 365 riassunti di comunicazioni a congressi pubblicati su riviste internazionali di cui

353 indicizzate 28 relazioni in esteso a congressi o seminari pubblicati su atti/dispense/CD (26) o

riviste (2); 82 riassunti di comunicazioni a congressi pubblicati su Atti di Congressi Congressi 313 partecipazioni a congressi e corsi di aggiornamento neurologici come relatore/

coautore in 277 (invitato in 185), moderatore in 107, organizzatore in 9, di cui: 162 nazionali, 151 internazionali

Seminari 80 Seminari e Conferenze ad invito presso Università, Istituzioni (Allegato B) FINAZIAMENTI RICEVUTI IRCCS Ospedale Maggiore Policlinico, Ricerca Corrente: Anni: 1988: 13.000.000; 1990: 20.000.000; 1991: 18.000.000; 1992:

15,275.000;1993: 55,275.000; 1994: 40.000.000; 1995: 84.145.534; 1996: 27.000.000; 1997: 44.000.000; 1998: 60.000.000; 1999: 29.438,04 €; 2000/2003: 40,000 €;

Progetti a concorso: Anni: 2001: 100.000.000; 2004: 25.822,84 €. IRCCS Istituto Clinico Humanitas, Progettidi ricerca interna: Anno 2008; 30,000 Telethon Italia: Progetto di Ricerca No, 486 (Bando 1993); durata 1 anno, 42.000.000; Progetto di Ricerca No, 674 (Bando 1995); durata 2 anni, 120.000.000. Associazione Italiana Sclerosi Multipla; Progetto Biennale 1988-1990, 50.000.000; Progetto Biennale 1994-1996, 50.000.000. Ministero dell’Istruzione dell’Università e della Ricerca: FIRB 2001: 50.000,00 € Università degli Studi di Milano FIRST 2002: 5956 €; FIRST 2003: 3089 €: FIRST 2004: 4190 €; FIRST 2005:4.858 € FIRST 2006: 4.647 €; FIRST 2007: 4.862€; PUR 2008: 4.193 €; PUR 2009: 7.000 € Regione Lombardia: 2014: Grant Biennale: “Database Lombardo per la CIDP”: Progetto Malattie Rare 2013

240.000€ GBS/CIDP International Foundation: 2016: Progetto di ricerca su “Studi immunologici nella CIDP”: 25,275$ Baxalta 2017: Grant triennale “Database Italiano sulla Neuropatia Motoria Multifocale”: 180.000€ CSL Behring 2017 e 2018: Grant annuale per “Database Italiano sulla CIDP”: 20.000 € + 20.000€ AIFA, Ricerca Indipendente 2018: Grant Triennale: ”Studio randomizzato controllato con Rituximab nella CDIP”:

Ricerca Indipendente 2016: 696.000 € Ministero della Salute, Ricerca Finalizzata 2018: Grant triennale: ”Studio immunologico nella CIDP e trattamento con rituximab nei

pazienti non responsivi a terapie convenzionali” Ricerca Finalizzata 2016: 450.000€

ATTIVITÀ EDITORIALE E INCARICH IN SOCIETÀ SCIENTIFICHE Membro dell’Editorial Board:

Neurological Sciences, Milano, Italia; Muscle & Nerve, USA: Expert Review of Neurotherapeutics, UK; Neurology and Clinical Neuroscience, Japan

Revisore ad hoc per 20 riviste internazionali o Enti di ricerca: (Allegato C) Premi e Incarichi direttivi in Società Scientifiche (Allegato C) Membro di Società Scientifiche (Allegato C) PARTECIPAZIONE E TRAINING IN TRIAL CLINICI

1998 IGF nella Sclerosi Laterale Amiotrofica, Studio internazionale multicentrico randomizzato

controllato in doppio cieco verso placebo di Fase III, Investigator 2001 IVIg verso Prednisolone nella CIDP, Studio internazionale multicentrico randomizzato controllato

in doppio cieco di Fase III, Principal Investigator (RAC Hughes Principal Investigator) 2002 IVIg vesro Placebo nella Polineuropatia cronica demielinizzante associate a gammopatia

monoclonale IgM, Studio internazionale multicentrico randomizzato di Fase III, Principal Investigator (Giacomo Comi Principal Investigator)

2006 Metotrexato verso Placebo come terapia aggiuntiva nella CIDP, Studio internazionale multicentrico randomizzato controllato di Fase III, Principal Investigator, Coordinatore per l’Italia (RMC trial). (Secondo il Good Clinical Practice) (RAC Hughes Principal Investigator)

2007 IVIg verso Metilprednisolone endovena nel trattamento prolungato della CIDP, studio nazionale multicentrico randomizzato controllato in doppio cieco di Fase III, Coordinatore dello Studio, Principal Investigator, (IMC trial). (Secondo il Good Clinical Practice)

2012 FTY720. A double-blind, randomized, multicenter, placebo-controlled, parallel-group study to evaluate the efficacy and safety of fingolimod 0.5 mg administered orally once daily versus placebo in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). Membro dello Steering Committee, National coordinator. Principal Investigator. (Sponsor Novartis;)

2014 I10E-1302. A European, multicentre, efficacy and safety study of I10E in initial and maintenance treatments of patients with Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) Responsabile Scientifico e Principal Investigator (Sponsor: LFB Francia,)

2014 I10E-1306. Extension of the European, multicentre, efficacy and safety study of I10E in patients with Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) to determine efficacy and safety of a dose reduction scheme to attempt withdrawal: a Descriptive Study. Responsabile Scientifico e Principal Investigator (Sponsor LFB Francia)

2018 CIDPRIT “An Italian Database-based randomized controlled trial with Rituximab in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP)” Responsabile Scientifico e Coordinatore dello studio, Principal Investigator (Ricerca Indipendenete AIFA 2016).

2018 Ricerca Finalizzata “Anti-nerve reactivity as predictor of response to immune therapy in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP):A proof of concept study with rituximab in patients with CIDP not responding toconventional immune therapy. Responsabile Scientifico e Coordinatore dello studio, Principal Investigator (Ministero della Salute, Ricerca Finalizzata 2016)

Training e Good Clinical Practice (GCP)

1. One day training GCP: RCT Trial Metotrexato nella CIDP, Londra Marzo 2006 2. One day training GCP: RCT IVIg nelle neuropatie dolorosa, Milano, 10 Febbraio 2012 3. GCP training (investigator version) 10 Settembre 2014 4. GCP refresh training (investigator version) 7 maggio 2018

ARTICOLAZIONE DELLE PRINCIPALI ATTIVITÀ

CLINICA Responsabile attività clinica-assistenziale prima della U.O. Neurologia 2 e poi il Servizio Autonomo Malattie Neuromuscolari e Neuroimmunologia dell’Istituto Clinico Humanitas presso cui si svolge la seguente attività: Attività di reparto per pazienti degenti con una media di 6 letti, Attività di Day Hospital, MAC e File F (4 letti di media al giorno), Attività ambulatoriale di neurologia generale, e di secondo livello per la diagnosi e terapia delle

neuropatie periferiche (2 ambulatori settimanali), sclrosi multipla (1 ambulatorio settimanale), Attività di neurofisiologia (EMG, EEG e potenziali evocati) per pazienti ambulatoriali e ricoverati, Attività di guardia neurologica per il pronto soccorso Attività di consulenza per gli altri reparti. Attività diagnostica di Neuroimmunologia (esame liquor e anìticorpi antinervo e anti-neurone) L’attività viene svolta insieme a 4 medici neurologi (due aiuti, un assistente e un Borsista di ricerca e clinica), un tecnico di Neurofisiologia e un Biologo. RICERCA

- Partecipazione allo Studio multicentrrico internazionale IGOS (International Guillain-Barré Outcome Study) Coordinatore Nazionale (Coordinatore Bart Jacobs, Olanda); In corso dal 2012

- Partecipazione allo Studio multicentrrico internazionale osservazionale Perinoms Study sulla stadardizzazione delle scale cliniche di valutazione nelle polineuropatie immuno mediate; Principal Investigator; (coordinatore Ingemar Merkies , Maastricht, Olanda). Dal 2008 al 2014

- Coordinatore dello studio CIDPRIT, “An Italian Database-based randomized controlled trial with Rituximab in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP)” Responsabile Scientifico (Ricerca Indipendenete AIFA 2016).

- Coordinatore dello studio “Anti-nerve reactivity as predictor of response to immune therapy in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): A proof of concept study with rituximab in patients with CIDP not responding to conventional immune therapy. Responsabile Scientifico (Ministero della Salute, Ricerca Finalizzata 2016)

- Partecipazione allo Studio IgM Anti-MAG peripheral Neuropathy: From proper Assessment to Trial needs IMAGiNe study, Coordinatore Nazionale (Coordinatore N. Notermans, Olanda). Dal 2018

- Paretcipazione agli studi internazionli dell’Inflammatory Neuropathy Cause And Treatment (INCAT) Group . Dal 2010

- Partecipazione alla sterusra delle Linee Guida della Peripheral Nerve Society/European Federation of Neurological Sciences (EFNS/PNS) sulla CIDP, MMN e neuropatia da gammopatia monoclonale. Dal 2008

- Parteciapazione alle stesura delle revisoni Cochrane sulla Neuropatie da gammopatia monoclonale IgM anti-MAG, neuropatia da gammopatia IgG e IgA e neuropatia motoria multifocale. Dal 2010

- Partecipazione agli studi di standardizzazione diagnostica della Associazione Italiana di Neuroimmunologia (AINI), Dal 2016

- Responsabile del Laboratorio di Neuroimmunologia prima all’Ospedale Maggiore Policlinico poi al all’Istituto Clinico Humanitas

ALLEGATI

A PUBBLICAZIONI (Lavori su Riviste e Capitoli su Libri) B ELENCO SEMINARI E CONFERENZE C ATIIVITA’ EDITORIALE E INCARICHI IN SOCIETA’ SCIENTIFICHE

Il/La Sottoscritto/a, ai sensi degli artt. 46 e 47 D.P.R. n. 445/2000, consapevole delle sanzioni penali previste

dall’art. 76 D.P.R. n. 445/2000 nel caso di mendaci dichiarazioni, falsità negli atti, uso o esibizione di atti falsi o contenenti dati non più corrispondenti a verità, dichiara che quanto sopra riportato corrisponde a verità. Dichiaro inoltre che i titoli e gli allegati sono, su richiesta, disponibili in copia fotostatica conforme agli originali. Autorizzo il trattamento dei miei dati personali ai sensi del Dlgs 196 del 30 giugno 2003

Milano, 12 Novembre 2018 EDUARDO NOBILE-ORAZIO (FIRMA)

ALL. A

PUBBLICAZIONI a) Lavori pubblicati su riviste scientifiche (IF 2016) 1. Nobile-Orazio E, Sterzi R. Cerebral Ischemia after Nifedipine treatment. British Medical Journal. 1981; 283: 948-949. IF: 20,785 2. Valli G, Ferini Strambi L, Nobile-Orazio E, Scarlato G. Idiopathic inflammatory polyradiculoneuropathy: evaluation of clinical and laboratory data and

therapeuthic considerations. Italian Journal of Neurological Sciences 1983; 1: 19-26. IF: 1,749 3. Nobile-Orazio E, Vietorisz T, Messito MJ, Sherman W, Latov N Anti-MAG IgM antibodies in patients with neuropathy and IgM M-proteins: detection by ELISA. Neurology 1983; 33: 939-942. IF: 8,320 4. Nobile-Orazio E, Latov N, Hays AP, Takatsu M, Abrams G, Sherman WH, Miller JR, Messito MJ,

Saito T, Tahmoush A,Lovelace RE, Rowland LP. Neuropathy and anti-MAG antibodies without detectable serum M-protein. Neurology 1984; 34: 218-221. IF: 8,320 5. Nobile-Orazio E, Hays AP, Latov N, Perman G, Golier G, Shy ME, Freddo L. Specificity of mouse and human monoclonal antibodies to the myelin associated glycoprotein. Neurology 1984; 34: 1336-1342. IF: 8,320 6 Shy ME, Vietorisz T, Nobile-Orazio E, Latov N. Specificity of human IgM M-proteins that bind to myelin associated glycoprotein: peptide mapping,

deglycosylation and competitive binding studies. Journal of Immunology 1984; 133: 2509-2512. IF: 4,856 7 Nobile-Orazio E, McIntosh C, Latov N. Anti-MAG antibodies and antibody complexes: detection by radioimmunoassay. Neurology 1985; 35: 988-992. IF: 8,320 8. Latov N, Godfrey M, Thomas Y, Nobile-Orazio E, Spatz L, Abraham J, Perman G, Freddo L,Chess L Neuropathy and anti-MAG IgM M-proteins: T cell regulation and M-protein secretion in vitro. Annals of Neurology 1985; 18: 182-188. IF: 9,890 9. Takatsu M, Hays AP, Latov N, Abrams GM, Nemni R, Sherman WH, Nobile Orazio E, Saito T,

Freddo L. Immunofluorescence studies of patients with neuropathy and IgM M-proteins. Annals of Neurology 1985; 18: 173-181. IF: 9,890 10. Candelise L, Landi G, Nobile-Orazio E, Boccardi E. Prognostic significance of hyperglycemia in acute stroke. Archives of Neurology 1985; 42: 661-663. IF: 10,029 11. Nobile-Orazio E, Spagnol G, Scarlato G. Failure to detect anti-MAG antibodies by RIA in CSF of patients with multiple sclerosis. Journal of Neuroimmunology 1986; 11:165-169. IF: 2,720 12. Nobile-Orazio E, Spagnol G, Daverio R, Riboni L, Macchi R, Francomano E, Scarlato G. Studies on anti-myelin antibodies in patients with multiple sclerosis. Rivista di Neurologia 1987; 57: 13-19. IF: n.n. 13. Bresolin N, Moggio M, Bet L, Gallanti A, Prelle A, Nobile-Orazio E, Addobbati L, Ferrante C,

Pellegrini G, Scarlato G. Progressive cytochrome c oxidase deficiency in a case of Kearns-Sayre Syndrome: morphological, immunological and biochemical studiesin muscle biopsies and autopsy tissues. Annals of Neurology 1987; 21: 564-572. IF: 9,890 14. Nobile-Orazio E, Marmiroli P, Baldini L, Spagnol G, BarbieriS, Moggio M, Polli N, Polli E, Scarlato

G Peripheral neuropathy in macroglobulinemia: incidence and antigen specificity of M-proteins. Neurology 1987; 37: 1506-1514. IF: 8,320 15. Barbieri S, Nobile-Orazio E, Baldini L, Fayoumi Z Manfredini E, Scarlato G. Visual evoked potentials in patients with neuropathy and macroglobulinemia.

Annals of Neurology 1987; 22: 663-666. IF: 9,890 16. Landi G, D'Angelo A, Boccardi E, Candelise L, Mannucci PM, Nobile-Orazio E, Morabito A. Hypercoagulability in acute stroke: prognostic significance. Neurology 1987; 37: 1667-1671. IF: 8,320 17 Della Casa Alberighi O, Nobile-Orazio E, Bonara P, Hu C, Spagnol G, Radelli L, Scorza Smeraldi R. NK cells in patients with peripheral neuropathy and IgM monoclonal protein reacting with the myelin

associated glycoprotein (MAG). Journal of Neuroimmunology 1988; 18: 207-216. IF: 2,720 18. Nobile-Orazio E, Baldini L, Barbieri S, Marmiroli P, Spagnol G, Francomano E, Scarlato G. Treatment of patients with neuropathy and anti-MAG IgM M-proteins. Annals of Neurology 1988; 24: 93-97 IF: 9,890 19. D'Angelo A, Landi G, Vigano' D'Angelo S, Nobile Orazio E, Boccardi E, Candelise L, Mannucci PM. Protein C in acute stroke Stroke 1988; 19: 579-583. IF: 6,032 20. D'Angelo A, Landi G, Candelise L, Nobile Orazio E, Vigano', D'Angelo S, Mannucci PM. Significance of reduced Protein C in patients with acue stroke and unfavourable prognosis. Thrombosis and Haemostasis 1988; 60 (2): 345. IF: 5,627 21. Nobile-Orazio E, Francomano E, Daverio R, Barbieri S, Marmiroli P, Manfredini E, Carpo M,

Moggio M, Legname G, Baldini L and Scarlato G. Anti-Myelin-Associated Glycoprotein IgM antibody titers in neuropathy associated with

macroglobulinemia. Annals of Neurology 1989; 26: 543-550. IF: 9,890 22. Marcus DM, Latov N, Hsi BP, Gillard BK, Antel J, Appel S, Callegaro L, Daune G, Gillard B, Latov

N, Marcus D, Nobile-Orazio E, Pestronk A, Portoukalian J, Quarles R, Salazar-Grueso E, Schneider, L, Shy M, Steck A.

Measurement and significance of antibodies against GM1 ganglioside. Report of a Workshop, 18/4/1989, Chicago, USA

Journal of Neuroimmunology 1989; 25: 255-259. IF: 2,720 23. Valli G, De Vecchi A, Gaddi L, Nobile-Orazio E, Tarantino A,Barbieri S. Peripheral nervous system involvement in essential cryoglobulinemia and nephropathy. Clinical and Experimental Rheumatology 1989; 7: 479-483. IF: 2,634 24. Monaco S, Bonetti B, Ferrari S, Moretto G, Nardelli E, Tedesco F, Mollnes TE, Nobile-Orazio E,

Manfredini E, Bonazzi L, Rizzuto N. Complement-mediated demyelination in patients with IgM monoclonal gammopathy and

polyneuropathy. New England Journal of Medicine 1990; 322: 649-652. IF: 72,406 25. Costa A, Baroni G, Piccolo G, Nobile-Orazio E, Lucio Liberato N, Ascari E. POEMS syndrome with IgA lambda monoclonal gammopathy. Haematologica 1990, 75: 170-172. IF: 7,702 26. Nobile-Orazio E, Legname G, Daverio R, Carpo M, Giuliani A, Sonnino S, Scarlato G. Motor neuron disease in a patient with a monoclonal IgMk directed against GM1, GD1b and high-

molecular-weight neural-specific glycoproteins. Annals of Neurology 1990; 28: 190-194. IF: 9,890 27. Nobile-Orazio E, Carpo M, Legname G, Meucci N, Sonnino S, Scarlato G. Anti-GM1 IgM antibodies in motor neuron disease and neuropathy. Neurology 1990; 40: 1747-1750. IF: 8,320 28. Scarlato G, Nobile-Orazio E. Motoneuron-disease-like disorder after ganglioside therapy. The Lancet 1991; 338: 314 (letter). IF: 47,831 29. Nobile-Orazio E, Carpo M, Scarlato G. Clinical relevance of anti-GM1 IgM antibodies. Acta Neurologica (Napoli) 1991; 13 (XLVI): 514-519. IF: n.n. 30. Froldi M, Castagna A, Piona A, Parma M, Tedeschi A, Miadonna A, Lorini M, Nobile-Orazio E,

Lazzarin A. Aumento della concentrazione liquorale di leucotriene B4 in pazienti con AIDS. Giornale di malattie infettive e parassitarie 1991; 43: 806-812. IF: n.n.

31. Nobile-Orazio E, Barbieri S, Baldini L, Marmiroli P, Carpo M, Premoselli S, Manfredini E, Scarlato G.

Peripheral neuropathy in monoclonal gammopathy of undetermined significance: prevalence and immunopathogenetic studies.

Acta Neurologica Scandinavica 1992; 85: 383-390. IF: 3,087 32. Nobile-Orazio E, Carpo M, Meucci N, Grassi MP, Capitani E, Sciacco M, Mangoni A, Scarlato G. Guillain Barre' Syndrome associated with high titers of anti-GM1 antibodies. Journal of the Neurological Sciences 1992; 109: 200-206. IF: 2,295 33. Froldi M, Castagna A, Parma M, Piona A, Tedeschi A, Miadonna A, Lorini M, Nobile-Orazio E,

Lazzarin A. Mediator release in cerebrospinal fluid of human immunodeficiency virus-positive patients with

central nervous system involvement. Journal of Neuroimmunology 1992; 38: 155-162. IF: 2,720 34. Landi G, D'Angelo A, Boccardi E, Candelise L, Mannucci PM, Morabito A, Nobile-Orazio E. Venous thromboembolism in acute stroke: prognostic importance of hypercoagulability. Archives of Neurology 1992; 49: 279-283. IF: 10,029 35. Nobile-Orazio E, Meucci N, Barbieri S, Carpo M, Scarlato G. High-dose intravenous immunoglobulin in multifocal motor neuropathy. Neurology 1993: 43: 537-544. IF: 8,320 36. Nobile-Orazio E, Meucci N, Barbieri S, Carpo M, Scarlato G. Immunoglobulin therapy. Neurology 1993; 43: 2727-8 (letter, reply). IF: 8,320 37. Heiman-Petterson T, Krupa T, Thompson P, Nobile-Orazio E, Tahmoush AJ, Shy ME. Anti-GM1/GD1b M-proteins damage human spinal cord neurons cocultured with muscle. Journal of the Neurological Sciences 1993; 120: 38-45. IF: 2,295 38. Baldini L, Nobile-Orazio E, Guffanti A, Barbieri S, Carpo M, Cro L, Cesana B, Damilano I, Maiolo

AT. Peripheral neuropathy in IgM monoclonal gammopathy and Waldenstrom macroglobulinemia: a

frequent complication in elderly males with low MAG-reactive serum monoclonal component. American Journal of Hematology 1994; 45: 25-31. IF: 5,275 39. Nobile-Orazio E, Carpo M, Scarlato G. Gangliosides: their role in clinical neurology Drugs 1994; 47: 576-585. IF: 5,000 40. Nobile-Orazio E, Manfredini E, Sgarzi M, Spagnol G, Allaria S, Quadroni M, Scarlato G. Serum IgG antibodies to a 35kDa P0-related glycoprotein in motor neuron disease. Journal of Neuroimmunology 1994, 53: 143-151. IF: 2,720 41. Nobile-Orazio E, Manfredini E, Carpo M, Meucci N, Monaco S, Ferrari S, Bonetti B, Cavaletti G,

Gemignani F, Durelli L, Barbieri S, Allaria S, Sgarzi M, Scarlato G. Frequency and clinical correlates of anti-neural IgM antibodies in neuropathy associated with IgM

monoclonal gammopathy. Annals of Neurology 1994; 36: 416-424. IF: 9,890 42. Froldi M, Parma M, Marenzi R, Piona A, Lorini M, Nobile-Orazio E, Castagna A, Lazzarin A. Low levels of LTB4 in cerebrospinal fluid of AIDS patients with cryptococcal meningitis. Journal of Clinical Laboratory Immunology 1995; 47 (1): 41-7. IF: n.n. 43. Monaco S, Ferrari S, Bonetti B, Moretto G, Kirshfink M, Nardelli E, Nobile-Orazio E, Zanusso G,

Rizzuto N, Tedesco F. Experimental induction of myelin changes by anti-MAG antibodies and terminal complement

complex. Journal of Neuropathology and Experimental Neurology 1995: 54:96-104. IF: 3,503 44. Barbieri S, Sandroni P, Nobile-Orazio E, Cappellari A, Cavestro C, Baldini L, Scarlato G. Small fiber involvement in neuropathy associated with IgG, IgA and IgM monoclonal gammopathy. Electromyography and Clinical Neurophysiology (ora Clinical Neurophysiology) 1995; 35: 39-44. IF: 3,866. 45. Ogino M, Nobile-Orazio (E), Latov N. IgG anti-GM1 antibodies from patients with acute motor neuropathy are predominantly of the IgG1

and IgG3 subclasses Journal of Neuroimmunology 1995; 58: 77-80. IF: 2,720

46. Manfredini E, Nobile-Orazio E, Allaria S, Scarlato G. Anti-alpha- and beta-tubulin IgM antibodies in dysimmune neuropathies. Journal of the Neurological Sciences 1995; 133: 79-84. IF: 2,295 47. Carpo M, Nobile-Orazio E, Chigorno V, Sonnino S. The anti-oligosaccharide antibodies present in sera from patients with motor neuron disease and

neuropathy recognize the N-glycolylneuraminic acid containing epitope. Glycoconjugate Journal 1995; 12: 729-731. IF: 2,186 48. Meucci N, Nobile-Orazio E, Scarlato G. Intravenous immunoglobulin therapy in amyotrophic lateral sclerosis. Journal of Neurology 1996; 243: 117-120. IF: 3,389 49. van den Berg L, Hays AP, Nobile-Orazio E, Kinsella LJ, Manfredni E,Corbo M, Rosoklija G,

Younger DS, Lovelace RE, Trojaburg W, Lange DE, Goldstein S, Delfiner JS, Sadiq S, Sherman WH, Latov N.

Anti-MAG and anti-SGPG antibodies in neuropathy. Muscle and Nerve 1996; 19: 637-643. IF: 2,605 50. Cappellari A, Nobile-Orazio E, Meucci N, Scarlato G, Barbieri S. Multifocal motor neuropathy: a possible source of error in the serial evaluation of conduction block. Muscle and Nerve 1996; 19: 666-669. IF: 2,605 51. Carpo M, Nobile-Orazio E, Meucci N, Gamba M, Barbieri S, Allaria S, Scarlato G. Anti-GD1a ganglioside antibodies in peripheral motor syndromes. Annals of Neurology 1996; 39: 539-543. IF: 9,890 52. Gemignani F, Marchesi G, Di Giovanni G, Salih S, Quaini F, Nobile-Orazio E. Low-grade non-Hodgkin B-cell lymphoma presenting as sensory neuropathy. European Neurology 1996; 36: 138-141. IF: 1,697 53. Nobile-Orazio E. Multifocal motor neuropathy (Editorial) Journal of Neurology, Neurosurgery and Psychiatry 1996; 60: 599-603. IF: 7,349 54. Cappellari A, Nobile-Orazio E, Meucci N, Scarlato G, Barbieri S,. Criteria for the early detection of conduction block in multifocal motor neuropathy (MMN): a study

based on control populations and follow-up of MMN patients. Journal of Neurology 1997; 244: 625-630. IF: 3,389 55. Meucci N, Cappellari A , Barbieri S, Scarlato G, Nobile-Orazio E. Long term effect of intravenous immunoglobulins and oral cyclophosphamide in multifocal motor

neuropathy. Journal of Neurology, Neurosurgery and Psychiatry 1997; 63: 765-769. IF: 7,349 56. Carpo M, Pedotti R, Lolli F. Pitrola A. Allaria S, Scarlato G, Nobile-Orazio E. Clinical correlate and fine specificity of anti-GQ1b antibodies in peripheral neuropathy. Journal of Neurological Sciences 1998; 155: 186-191. IF: 2,295 57. Spagnol G, Doneda P, Cavanna B, Sgarzi M, Manfredini E, Allaria S, Scarlato G, Nobile-Orazio E. Expression of glycosylated recombinant human myelin-associated glycoprotein (MAG) on a

neuroblastoma cell line and its reactivity with HNK-1 but not human anti-MAG antibodies. Neuroscience Letters 1998; 246(3): 157-160. IF: 2,180 58. Carpo M, Cappellari A, Mora G, Pedotti R, Barbieri S, Scarlato G, Nobile-Orazio E. Deterioration of multifocal motor neuropathy after plasma exchange. Neurology 1998; 50:1480-1482. IF: 8,320 59. Borasio GD, Robberecht W, Leigh PN, Emile J, Guiloff RJ, Jerusalem F, Silani V, Vos PE, Wokke

JHJ, Dobbins T, and the European ALS/IGF-1 Study Group (tra cui E. Nobile-Orazio, vedi appedice) A placebo-controlled trial of insuline-like growth factor-I in amyotrophic lateral sclerosis. Neurology 1998; 51: 583-586. IF: 8,320 60. Pedotti R, Carpo M, Lucchi S, Righini A, Scarlato G, Nobile-Orazio E. Lumbosacral root and facial nerve enhancement in Miller Fisher syndrome. Journal of Neurology 1998; 245: 753-754. IF: 3,389 61. Nobile-Orazio E, Carpo M Rilevanza diagnostica degli anticorpi antinervo nelle neuropatie disimmuni Italian Journal of Neurological Sciences 1998; 19 (suppl): S136-S140. IF: 1,749 62. Ferrari S, Morbin M, Nobile-Orazio E, Musso A, Tomelleri G, Bertolasi L, Rizzuto N, Monaco S. Anti-sulfatide neuropathy: antibody mediated complement attack to peripheral myelin.

Acta Neuropathologica 1998; 96: 569-574. IF: 12,213 63. Maccario M, Tarantino A, Nobile-Orazio E, Ponticelli C. Campylobacter jejuni bacteremia and Guillain Barré syndrome in a renal transplant recipient. Transplant International 1998; 11: 439-442. IF: 3,079 64. Meola G, Sansone V, Rotondo G, Nobile-Orazio E, Mongini T, Angelini C, Toscano A, Mancuso M,

Siciliano G. PROMM in Italy: Clinical and Biomolecular findings. Acta Myologica 1998; Vol. II: 21-26. IF: n.n. 65. Cavanna B, Carpo M, Pedotti R, Meucci N, Allaria S , Scarpini E, Scarlato G, Nobile-Orazio E. Anti-GM2 IgM antibodies: clinical correlates and reactivity with a human neuroblastoma cell line. Journal of Neuroimmunology 1999; 94: 157-164. IF: 2,720 66. Di Troia A, Carpo M, Meucci N, Pellegrino C, Allaria S, Gemignani F, Marbini A, Mantegazza R,

Sciolla R, Manfredini E, Scarlato G, Nobile-Orazio E. Clinical features and anti-neural reactivity in neuropathy associated with IgG monoclonal

gammopathy of undetermined significance Journal of the Neurological Sciences 1999; 164: 64-71. IF: 2,295 67. Meucci N, Baldini L, Cappelari A, Di Troia A, Allaria S, Scarlato G, Nobile-Orazio E. Anti-MAG antibodies predict the development of neuropathy in asymptomatic patients with IgM

monoclonal gammopathy. Annals of Neurology 1999; 46: 119-122. IF: 9,890 68. Carpo M., Pedotti R, Allaria S, Lolli F, Matà S, Cavaletti G, Protti A, Pomati S, Scarlato G, Nobile-

Orazio E. Clinical presentation and outcome of Guillain-Barré and related syndromes in relation to anti-

ganglioside antibodies Journal of the Neurological Sciences 1999, 168: 78-84. IF: 2,295 69. Carpo M, Allaria S, Scarlato G, Nobile-Orazio E. Marginally improved detection of GM1 antibodies by covalink ELISA in multifocal motor

neuropathy. Neurology 1999; 53 2206-7. IF: 8,320 Comment in: 70. Nobile-Orazio E, Carpo M, Scarlato G. Testing for serum IgM binding to GM1 in clinical practice. Neurology 2000; 54: 2353 (letter, reply). IF: 8,320 71. Nobile-Orazio E, Carpo M, Allaria S, Gamba M. Diagnostic relevance of anti-neural antibodies in dysimmune neuropathies. Electroencephalography and Clinical Neurophysiology 1999 (ora Clinical Neurophysiology);

Supplement 50 (Clinical Neurophysiology: from receptor to perception. G. Comi, CH Lucking, J Kimura, PM Rossini, eds.): 419-427. IF: 3,866

72. Nobile-Orazio E, Meucci N. High-dose intravenous immuno-globulins in multifocal motor neuropathy. Electroencephalography and Clinical Neurophysiology 1999 (ora Clinical Neurophysiology);

Supplement 50 (Clinical Neurophysiology: from receptor to perception. G. Comi, CH Lucking, J Kimura, PM Rossini, eds.): 506-513. IF: 3,866

73. Merkies ISJ, Schmitz PIM, Samijn JPA, van der Meche FGA, van Doorn PA, for the European Inflammatory Neuropathy Cause andTreatment (INCAT) Group (Aubry J, Baumann N, Bouche P, Comi G, Dalakas MC, Hartung HP, Hughes RAC; Illa I, Knapp MRJ, Léger J-M, Nemni R, Nobile-Orazio E, Toyka KV, van de Bergh P, van der Meché FGA, van Doorn PA, Willison HJ, Younes-Chennoufi B)

Fatigue in immune-mediated polyneuropathies Neurology 1999; 53; 1648-1654. IF: 8,320 74. Merkies ISJ, Schmitz PIM, van der Meché FGA, van Doorn, PA for the Inflammatory Neuropathy

Cause and Treatment (INCAT) Group (Aubry J, Baumann N, Bouche P, Comi G, Dalakas MC, Hartung HP, Hughes RAC; Illa I, Knapp MRJ, Léger J-M, Nemni R, Nobile-Orazio E, Toyka KV, van de Bergh P, van der Meché FGA, van Doorn PA, Willison HJ, Younes-Chennoufi B)

Psychometric evaluation of a new sensory scale in immune-mediated polyneuropathies Neurology Neurology 2000; 54:943-949 IF: 8,320

75. Merkies IS, Schmitz PI, Samijn JP, Meché FG, Toyka KV, van Doorn PA, Aubry J, Baumann N, Bouche Comi G, Dalakas MC, Hartung HP, Hughes RAC, Illa I, Knapp MRJ, Lge, J-M, Nemni R, Nobile-Orazio E, Toyka KV, Van De Bergh P, Van Der Meché FGA, Willison HJ, Younes-Chennoufi B. Assessing grip strength in healthy individuals and patients with immune-mediated polyneuropathies

Muscle and Nerve 2000; 23: 1393-1401 IF: 2,605 76. Nobile-Orazio E, Meucci N, Baldini L, Di Troia A, Scarlato G. Long-term prognosis of neuropathy associated with anti-MAG IgM M-proteins and its relation with

immune therapies. Brain 2000; 123: 710-717. IF: 10,292 77. Odaka M, Yuki N, Nobile-Orazio E, Carpo M, Hiraka K. Antibodies to GM1(NeuGc) in Guillain Barré syndrome after ganglioside therapy. Journal of the Neurological Sciences 2000; 175: 96-106. IF: 2,295 78. Carpo M, Meucci N, Allaria S, Marmiroli P, Monaco S, Toscano A, Simonetti S, Scarlato G,

Nobile-Orazio E. Anti-sulfatide IgM antibodies in peripheral neuropathy. Journal of the Neurological Sciences 2000; 176: 144-150. IF: 2,295 79. Prelle A, Sciacco M, Comi GP, Messina S, Carpo M, Ciscato P, Nobile-Orazio E, Fortunato F, Mora

G, Bignotti V, Fagiolari G, Moggio M, Scarlato G. A sporadic, atypical case of desminopathy: morphological and immunological characterization. Clinical Neuropathology 2000; 19: 208-212. IF: 1,532 80. Guillain-Barré Syndrome Study group (Nappi G, Scarlato G, Citterio A, Molinari S, Cosi V, Piccolo

G, Bono G, Faggi L, Mariani G, Nobile Orazio E, Matozzo F, Vitelli E, Carpo M, Pellegrino C, Bersano A, Antozzi C, Pinardi G, Protti A, Marazzi R, Gambaro P, Vecchio C, Poloni M, Albizzati AM, De Simone V, Bordo B, Mattioli M, Ciani M, Perrone P, Marsile C, Bascelli C, Beghi E, Bogliun G, Rotondo G, Crespi V, Marmiroli P, Magrotti E, Delodovici ML, La Spina I, Frazzitta G, Perini M, Bassi P, Gomitoni A)

The Guillain-Barré syndrome: an Italian multicenter case-control study. Neurological Sciences 2000; 21: 229-234 IF: 1,749 81. Buchwald B, Bufler J, Carpo M, Heidenreich F, Pitz R, Dudel J, Nobile-Orazio E, Toyka KV. Combined pre- and postsynaptic action of IgG antibodies in Miller Fisher syndrome. Neurology 2001; 56: 67-74. IF: 8,320 82. Cavanna B, Jiang H, Allaria S, Carpo M, Scarlato G, Nobile-Orazio E. Anti-GM2 IgM antibody-induced complement-mediated cytotoxicity in patients with dysimmune

neuropathies. Journal of Neuroimmunology 2001; 114: 226-231. IF: 2,720 83. Nobile-Orazio E. Multifocal motor neuropathy. (Review Article) Journal of Neuroimmunology 2001; 115: 4-18 IF: 2,720 84. Nobile-Orazio E, Carpo M, Meucci N. Are there immunologically treatable motor neuron diseases? Amyotrophic lateral sclerosis and other motor neuron disorders 2001;2(sup 1):S23-30. IF: 3,054 85. European workshop on multifocal neuropathy (Buchwald B, Franssen H, Hughes RAC, Léger J-M,

Leigh N, Mills KR, Nobile-Orazio E, Pouget J, Toyka KV, Van den Berg LH, Van den Bergh P, Van Doorn PA, Plomp JJ, Visser MC, Willison HJ, Wokke JHJ)

79th ENMC interantional workshop: Multifocal motor neuropathy (Workshop report). Neuromuscular Disorders 2001; 11: 309-314. IF: 2,969 86. Hughes RAC, Bensa S, Willison HJ, van den Bergh P, Comi G, Illa I, Nobile-Orazio E, van Doorn P,

Dalakas M, Bojar M, Swan A and the Inflammatory Neuropathy Cause and Treatment (IINCAT) group.

Randomized controlled trial of intravenous immunoglobulin versus oral prednisolone in chronic inflammatory demyelinating polyradiculoneuropathy

Annals of Neurology 2001; 50: 195-201. IF: 9,890 87. Nobile-Orazio E, Carpo M. Neuropathy and monoclonal gammopathy. Current Opinion in Neurology 2001; 14: 615-620. IF: 4,699 88. Nobile-Orazio E, Meucci N, Carpo M, Terenghi, Bersano A, Cappellari A, Barbieri S, Scarlato G.

Multifocal motor neuropathy: clinical and immunological features and response to IVIg in relation to the presence and degree of motor conduction block.

Journal of Neurology, Neurosurgery and Psychiatry 2002; 72:761-6. IF: 7,349 89. Terenghi F, Allaria S, Scarlato G, Nobile-Orazio E. Multifocal motor neuropathy and Campylobacter jejuni reactivity.

Neurology 2002; 59: 282-284 IF: 8,320 90. Toscano A, Rodolico C, Benvenga S, Girlanda P, Laurà M, Mazzeo A, Nobile-Orazio E, Trimarchi F,

Vita G, Messina C. Multifocal motor neuropathy and asymptomatic Hashimotos’s thyroiditis: first report of an association Neuromuscular disorders 2002; 12: 566-568. IF: 2,969 91. Nobile-Orazio E, Bersano A. High-dose intravenous immunoglobulin therapy in dysimmune neuropathies Neurological Sciences 2002; 23 (Suppl 1): S25-S32 IF: 1,749 92. Umapathi T, Hughes RAC, Nobile-Orazio E, Leger JM Immunosuppressive tratment for multifocal motor neuropathy Cochrane Database of Systematic Reviews 2002; Issue 3. Oxford:Update Software IF: 6,264. 93. Nobile-Orazio E, Casellato C, Di Troia A. Neuropathies associated with IgG and IgA monoclonal gammopathy. Revue Neurologique (Paris) 2002; 158: 979-987 IF: 1,039 94. Comi G, Roveri L, Swan A, Willison H, Bojar M, Illa I, Karageorgiou C, Nobile-Orazio E, van den

Bergh P, Swan T, Hughes RAC and the Inflammatory Neuropathy Cause and Treatment (INCAT) group.

A randomised controlled trial of intravenous immunoglobulin in IgM paraprotein associated demyelinating neuropathy.

Journal of Neurology 2002; 249: 1370-1377 IF: 3,389 95. Priori A, Cinnante C, Pesenti A, Carpo M, Cappellari A, Nobile-Orazio E, Scarlato G, Barbieri S Distinctive abnormalities of motor axonal strength-duration properties in multifocal motor neuropathy

and in motor neuron disease Brain 2002;125: 2481-90 IF: 10,292 96. Lunn M., Nobile-Orazio E. Immunnotherapy for IgM anti-Myelin-associated Gglycoprotein paraprotein associated neuropathy The Cochrane Database of Systematic Reviews 2003; Issue 1. Oxford :Update Software IF: 6,264 97. Micco A, Nobile-Orazio E, Baron P, Conti G, Napoli L, Serafini M, Scarlato G, Scarpini E. Severe chronic sensory-motor polyneuropathy: coexistence of 3 unrelated etiologies in a type 1

diabetic patient. A case report and review of the literature Journal of the Peripheral Nervous System 2003; 8: 23-28 IF: 2,258 98. De Giorgio R, Bovara M, Barbara G, Canossa M, Sarnelli G, De Ponti F, Stanghellini V, Tonini M,

Cappello S, Pagnotta E, Nobile-Orazio E, Corinaldesi R. Anti-HuD-induced neuronal apoptosis underlying paraneoplastic gut dysmotility. Gastroenterology 2003 Jul;125(1):70-9. IF: 18,392 99. McCrone P, Chisholm D, Knapp M, Hughes R, Comi G, Dalakas M, Illa I, Kilindireas C, Nobile-

Orazio E, Swan A, Van den Bergh P, Willison HJ, the INCAT Study Group Cost-Utility Analysis of Intravenous immunoglobulin and Prednisolone for Chronic Inflammatory

Demyelinating Polyradiculoneuropathy (CIDP) European Journal of Neurology 2003; 10: 687-694 IF: 3,988 100. Nobile-Orazio E, Terenghi F, Carpo M, Bersano A. Treatment of multifocal motor neuropathy Neurological Sciences 2003; 24 (Suppl 4): S251-S255 IF: 1,749 101. Nobile-Orazio E, Terenghi F Other Dysimmune neuropathies. In : Peripheral Neurologic Disease Continuum, Lifelong Learning in Neurology. December 2003; Volume 9, No. 6: 56-85 IF: n.n. 102. Terenghi F, Cappellari A, Versano A, Carpo M, Barbieri S, Nobile-Orazio E How-long is IVIg effective in multifocal motor neuropathy? Neurology 2004; 62:666-8. IF: 8,320 103. Bersano A, Carpo M, Cappellari A, Bresolin N, Nobile-Orazio E Transient response to immune therapies in post-irradiation lumbosacral radiculoplexopathy.

Journal of Neurology 2004; 251; 488-490 IF: 3,389 104. Nobile-Orazio E IgM paraproteinaemic neuropathies.

Current Opinion in Neurology 2004; 17(5): 599-605 IF: 4,699 105. Nobile-Orazio E. Neuropathy and monoclonal gammopathy Haematologica 2004; 89 (Suppl. 1) : 23-29. IF: 7,702 106. Basilisco G, Gebbia C, Peracchi M, Velio P, Conte D, Bresolin N, Nobile-Orazio E. Cerebellar degeneration and hearing loss in a patient with idiopathic myenteric ganglionitis.

European Journal Gastroenterology and Hepatology 2005 Apr;17(4):449-52. IF: 1,968 107. Padua L, Schenone A, Aprile I, Benedetti L, Calandro P, Tonali P, Nobile-Orazio E for the Italian

NEUROPA Study Group Qualità of life and disability assessment in neuropathy: a multicenter study. Journal of the Peripheral Nervous System 2005; 10: 3-10 IF: 2,258 108. Nobile-Orazio E Treatment of Dysimmune Neuropathies. ENS Teaching Review Journal of Neurology 2005; 252 (4): 385-95. IF: 3,389 109. Nobile-Orazio E, Cappellari A, Priori A. Multifocal Motor Neuropathy: current concepts and controversies Muscle and Nerve 2005; 31: 663 - 680 IF: 2,605 110. Hughes R on behalf of the CIDPand MMN trial group (Blomkwist P, Hughes R, Illa I, Léger J-M,

McCrone P, Murphy C, Nobile-Orazio E, Swan A, van den Berg L, van den Bergh P, van Doorn P, van Schaik I)

129th ENMC International Workshop: Clinical Trials for Chronic Inflammatory Demyelinating Polyradiculoneuropathy and Multifocal Motor Neuropathy, 27th October 2004, Schiphol Airport, The Netherlands.

Neuromuscular Disorders 2005;15: 321-5. IF: 2,969 111 Nobile-Orazio E, Terenghi F. IVIg in idiopathic autoimmune neuropathies: analysis in the light of the latest results Journal of Neurology 2005; 252 (Suppl 1): 1/7-1/13 IF: 3,389 112. Priori A, Bossi B, Ardolino G, Bertolasi L, Carpo M, Nobile-Orazio E, Barbieri S. Pathophysiological heterogeneity of conduction blocks in multifocal motor neuropathy. Brain. 2005; 128:1642-8. IF: 10,292 113. Scarlato M, Previtali SC, Carpo M, Pareyson D, Briani C, Del Bo R, Nobile-Orazio E, Quattrini A,

Comi GP Polyneuropathy in POEMS syndrome: role of angiogenic factors in the pathogenesis.

Brain. 2005; 28:1911-20. IF: 10,292 114. Umapathi T, Hughes R, Nobile-Orazio E, Leger J Immunosuppressant and immunomodulatory treatments for multifocal motor neuropathy.

Cochrane Database of Systematic Reviews 2005 Jul 20 (3): IF: 6,264. 115. Joint Task Force of the EFNS and the PNS (Hughes RAC, Bouche P, Cornblath DR, Evers E, Hadden

RD, Hahn AF, Illa I, Koski CL, Léger J-M, Nobile-Orazio E, Pollard JD, Sommer C, Van den Bergh P, van Doorn PA, van Schaik I)

European Federation of Neurological Societies/Peripheral Nerve Society Guideline on management of chronic inflammatory demyelinating polyradiculoneuropathy. Report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society

Journal of the Peripheral Nervous System 2005; 10: 220-228 IF: 2,258 116. Franciotta D, Avolio C, Capello E, Lolli F, AINI participating members (Trojano M, Leante R,

Falcone M, Marrosu M, Costa G, Murru MR, Cocco E, Galli E, Chicchi A, Maimone D, Cuccia S, Lugaresi A, Pantalone A, Paolino E, Castellazzi M, Zaffaroni M, Villa C, Giunti D, Panarese C, Ribizzi G, Vita G, Aguennouz M, Ciranni AM, Salmaggi A, Bernardi G, Ciusani E, Passerini G, Nobile-Orazio E, Carpo M, Allaria S, Merelli E, Bedin R, Bertolotto A, Sala A, Gallo P, Zardini E, Andreoni L, Siciliano G, Bacci A, Meucci G, Simone P, Desina G, Di Viesti P, Apollo F, Sotgiu S, Deiana G, Annunziata P, Morucci A, Bonetti B, Alberti D.

Consensus recommendations of the Italian Association for Neuroimmunology for immunochemical cerebrospinal fluid examination.

Journal of the Neurological Sciences, 2005; 237: 5–11 IF: 2,295

117. Bersano A, Carpo A, Allaria A, Franciotta D, Citterio A, Nobile-Orazio E Long term disability and social status change after Guillain-Barré syndrome Journal of Neurology 2006; 253: 214-218 IF: 3,389 118. Joint Task Force of the EFNS and the PNS (Hughes RAC, Bouche P, Cornblath DR, Evers E, Hadden

RD, Hahn AF, Illa I, Koski CL, Léger J-M, Nobile-Orazio E, Pollard JD, Sommer C, Van den Bergh P, van Doorn PA, van Schaik I)

European Federation of Neurological Societies/Peripheral Nerve Society Guideline on management of multifocal motor neuropathy. Report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society

Journal of the Peripheral Nervous System 2006; 11: 1-8 IF: 2,258 119. Joint Task Force of the EFNS and the PNS (Hadden RD, Nobile-Orazio E, Sommer C, Hahn AF, Illa

I, Morra E, Pollard JD, Hughes RAC, Bouche P, Cornblath DR, Evers E, Koski CL, Léger J-M, Van den Bergh P, van Doorn PA, van Schaik I)

European Federation of Neurological Societies/Peripheral Nerve Society Guideline on management of paraproteinemic demyelinating neuropathy. Report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society

Journal of the Peripheral Nervous System 2006; 11: 9-19 IF: 2,258 120. Terenghi F, Allaria S, Nobile-Orazio E Circulating levels of cytokines and their modulation by IVIg in multifocal motor neuropathy Journal of the Peripheral Nervous System 2006; 11: 67-71 IF: 2,258 121. Hughes RAC, Bouche P, Cornblath DR, Evers E, Hadden RD, Hahn AF, Illa I, Koski CL, Léger J-

M, Nobile-Orazio E, Pollard JD, Sommer C, Van den Bergh P, van Doorn PA, van Schaik I Response to comment on European Federation of Neurological Societies/Peripheral Nerve Society

Guideline on management of chronic inflammatory demyelinating polyradiculoneuropathy. Journal of the Peripheral Nervous System 2006; 11: 90-91 (letter, reply) IF: 2,258 122. Lunn MPT, Nobile-Orazio E Immunotherapy for IgM anti-myelin-associated glycoprotein paraprotein-associated peripheral

neuropathies [Review] Cochrane Database Systematic Reviews 2006; (2) IF: 6,264 123. Hughes RA, Bouche P, Cornblath DR, Evers E, Hadden RD, Hahn A, Illa I, Koski CL Leger JM,

Nobile-Orazio E, Pollard J, Sommer C, Van den Bergh P, van Doorn PA, van Schaik IN. European Federation of Neurological Societies/Peripheral Nerve Society guideline on management of

chronic inflammatory demyelinating polyradiculoneuropathy: report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society. European Journal of Neurology 2006; 13: 326-332. IF: 3,988

124. van Schaik IN, Bouche P, Illa I, Leger JM, Van den Bergh P, Cornblath DR, Evers E, Hadden RD, Hughes RA, Koski CL, Nobile-Orazio E, Pollard J, Somner C, van Doorn PA,

European Federation of Neurological Societies/Peripheral Nerve Society guideline on management of multifocal motor neuropathy.

European Journal of Neurology 2006;13: 802-8. IF: 3,988 125. Hadden RD, Nobile-Orazio E, Hahn A, Illa I, Morra E, Pollard J, Hughes RA, Bouche P, Cornblath

DR, Evers E, , Koski CL, Leger JM, , Van den Bergh P, van Doorn PA, van Schaik IN. European Federation of Neurological Societies/Peripheral Nerve Society guideline on management of

paraproteinaemic demyelinating neuropathies: report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society.

European Journal of Neurology 2006; 13: 809-18. IF: 3,988 126. Bersano A, Fiorini M, Allaria S, Zanusso G, Fasoli E, Gelati M, Monaco H, Squintani G, Monaco S,

Nobile-Orazio E.Detection of CSF 14-3-3 protein in Guillain Barré syndrome Neurology 2006; 67: 2211-2216 IF: 8,320 127. Allen D, Lunn MPT, Niermeijer J, Nobile-Orazio E, Treatment for IgG and IgA paraproteinemic neuropathy. Cochrane Database of Systematic Reviews 2007, Issue 1, Art. No. CD005376 IF: 6,264 128. Ardolino G, Bossi B, Barbierib B, Nobile-Orazio E, Priori A. Pathophysiology of conduction block in multifocalmotor neuropathy Schweizer Archive fur Neurologie und Psychiatrie 2007;158:78–80. IF: n.n. 129. Benedetti L, Briani C, Grandis M, Vigo T, Gobbi M, Ghiglione E, Carpo M, Cocito D, Caporale C,

Soriani MP, Mancardi GL, Nobile-Orazio E, Schenone A.

Predictors of response to Rituximab in patients with neuropathy and anti-myelin associated glycoprotein immunoglobulin M.

Journal of the Peripheral Nervous System 2007; 12: 102-107 IF: 2,258 130. Terenghi F, Ardolino GL, Nobile-Orazio E. Guillain-Barré syndrome after combined CHOP and rituximab therapy in non-hodgkin lymphoma. Journal of the Peripheral Nervous System 2007; 12: 142-143 IF: 2,258 131. Cavaletti G, Nobile-Orazio E, Bortezomib-induced peripheral neurotoxicity: still far from a painless gain. Haematologica 2007; 92: 1308-9 (editorial) IF: 7,702 132. Nobile-Orazio E, Gallia F, Terenghi F, Allaria S, Giannotta C, Carpo M How useful are anti-neural IgM antibodies in the diagnosis of chronic immune-mediated neuropathies?

Journal of the Neurological Sciences. 2008; 266:156-63 IF: 2,295 133. Ardolino G, D’Adda E, Nobile-Orazio E Recurrent atrial fibrillation after subcutaneous apomorphine. Parkinsonism & Related Disorders 2008;14:173-4; IF: 4,484 134. Nobile-Orazio E, Evidence for long-term IVIg treatment of chronic inflammatory demyelinating

polyradiculoneuropathy. Nature Clinical Practice Neurology (ora Nature Review Neurology) 2008; 4: 352-3 IF: 20,257 135. Benedetti L, Briani C, Franciotta D, Carpo M, Padua L, Zara G, Zambello R, Sormani MP, Mancardi

GL, Nobile-Orazio E, Schenone A Long-term effect of Rituximab in anti-MAG polyneuropathy

Neurology 2008; 71: 1742-1744 IF: 8,320 136. van Nes I, Faber CG, Hamers RM,Harschnitz O, Bakkers M, Hermans MC, Meijer RJ, van Doorn PA,

Merkies IS and the Perinoms Study Group (Bennett D, van den Berg LH, Van den Bergh PY, Cornblath DR, DalakaS M, van Doorn PA, Faber CG, Gorson KC, Hadden RD, Hahn AF, Hughes RA, Lauria G, Léger JM, Lewis RA, Lunn PT, Merkies IS, Nobile-Orazio E, Notermans NC, Padua L, Reilly MM)

Revising two-point discrimination assessment in normal aging and in patients with polyneuropathies Journal of Neurology Neurosurgery & Psychiatry 2008 Jul;79(7):832-4. IF: 7,349 137. Nobile-Orazio E What is new in multifocal motor neuropathy in 2007-2008 Journal of the Peripheral Nervous System 2008; 13: 261-263 IF: 2,258 138. Umapathi T, Hughes R, Nobile-Orazio E, Leger J Immunosuppressant and immunomodulatory treatments for multifocal motor neuropathy.

Cochrane Database Systematic Reviews 2009 Jan 21;(1):CD003217 IF: 6,264 139. Galassi G, Girolami F, Nobile-Orazio E, Funakoshi K, Ariatti A, Odaka M Acute hand weakness as a regional variant of Guillain-Barré syndrome European Journal of Neurology 2009; 16: e49 (letter) IF: 3,988 140. RMC Trial Group (Mahdi-Rogers M, Rutterford C, Hughes RA, Léger JM, Nobile-Orazio E, Van den

Bergh P, van Doorn P, van Schaik IN, Hadden RD, Choy E, Reilly M, Winer J, Evers E, Créange A, Gueguen A, Uzenot D, Behin A, Nicolas G, Pautot V, Uncini A, Manzoli C, Lauria G, Pareyson D, Casellato C, Sabatelli M, Conte A, Luigetti M, Briani C, Lucchetta M, Schenone A, Benedetti L, Fiorina E, Brusse E, van der Kooi AJ, Guiloff RJ, Rakowicz WP, Lecky BR, Dougan CF, Marshall D, Davies N, Busby M, Lansbury A, Overell J, Willison HJ, Rajabally YA, Kendall B, Gow D, Nixon J, Kulkarni O, Katifi H, Hammans S, Gibson A, McDermott C, Cornblath DR, Chaudry V)

Pilot Randomised Controlled Trial of Methotrexate for Chronic Inflammatory Demyelinating Polyradiculoneuropathy (RMC Trial) Lancet Neurology 2009; 8: 158-164 DOI: 10.1016/S1474-4422(08)70299-0 IF: 26,284

141. Padua L, Briani C, Jann S, Nobile-Orazio E., Pazzaglia C, Morini A, Mondelli M, Ciaramitaro P, Cavaletti G, Cocito D, Fazio R , Santoro L, Galeotti F, Carpo M, Plasmati R, Benedetti L, Schenone A, Marchettini P, Cruccu G.

Validation of the Italian version of the Neuropathic Pain Symptom Inventory (NPSI) in peripheral nervous system diseases.

Neurological Sciences 2009; 30: 99-106 IF: 1,749 142. Nobile-Orazio E, Terenghi F, Giannotta C, Gallia F, Nozza A. Serum VEGF levels in POEMS syndrome and in immune-mediated neuropathies.

Neurology 2009; 72(11): 1024-6. IF: 8,320 143. Nobile-Orazio E. Antigenic determinants in IgM parapotein-related neuropathies. Clinical Lymphoma & Myeloma (già Clinical Lymphoma) 2009 Feb; 9(1):107-9. IF: 2,494 144. The CI-PERINOMS study Group (including Nobile-Orazio E.) Announcement: CI-PERINOMS: chemotherapy-induced peripheral neuropathy outcome measures

study Journal of the Peripheral Nervous System 2009; 14: 69-71 IF: 2,258 145. Nobile-Orazio E, Terenghi F, Cocito D, Gallia F, Casellato C. Oral methotrexate as adjunctive therapy in patients with Multifocal Motor Neuropathy on chronic

IVIg therapy. Journal of the Peripheral Nervous System 2009; 14: 203-205 IF: 2,258 146. van Nes SI, Vanhoutte EK, Faber CG, Garssen M, van Doorn PA, Merkies IS and the PeriNomS Study

Group (Bennett D, van den Berg LH, Van den Bergh PY, Cornblath DR, Dalakas M, Devigili G, van Doorn PA, Faber CG, Gorson KC, Hadden RD, Hahn AF, Hartung HP, Hughes RA, Lauria G, Léger JM, Lewis RA, Lunn MP, Merkies IS, Nobile-Orazio E, Notermans NC, Padua L, Reilly MM, Smith B).

Improving fatigue assessment in immune-mediated neuropathies: the modified Rasch-built fatigue severity scale.

Journal of the Peripheral Nervous System 2009; 14: 268-78. IF: 2,258 147. Cocito D, Paolasso I, Antonini G, Benedetti L, Briani C, Comi C, Fazio R, Jann S, Matà S, Mazzeo A,

Sabatelli M, Nobile-OrazioE. A nationwide retrospective analysis on the effect of immune therapies in patients with Chronic

Inflammatory Demyelinating Polyneuropathy. European Journal of Neurology 2010; 17: 289-294 IF: 3,988 148. Nobile-Orazio E, Giannotta C, Briani C Anti-ganglioside complex IgM antibodies in multifocal motor neuropathy and chronic immune-

mediated neuropathies Journal of Neuroimmunology 2010; 219: 119-122 IF: 2,720 149. Van den Bergh PYK , Hadden RDM , Bouche P , Cornblath DR , Hahn A , Illa I, Koski CL, Léger J-

M , Nobile-Orazio E , Pollard J , Sommer C , van Doorn PA, van Schaik IN. European Federation of Neurological Societies/Peripheral Nerve Society Guideline on management of

chronic inflammatory demyelinating polyradiculoneuropathy: Report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society — First Revision

European Journal of Neurology 2010; 17: 356-363 IF: 3,988 150. Joint Task Force of the EFNS and the PNS (Van den Bergh PY, Hadden RD, Bouche P, Cornblath

DR, Hahn A, Illa I, Koski CL, Léger JM, Nobile-Orazio E, Pollard J, Sommer C, van Doorn PA, van Schaik IN)

European Federation of Neurological Societies/Peripheral Nerve Society Guideline on management of chronic inflammatory demyelinating polyradiculoneuropathy: Report of a joint task

force of the European Federation of Neurological Societies and the Peripheral Nerve Society – First Revision

Journal of the Peripheral Nervous System 2010; 15: 1-9 IF: 2,258 151. Nobile-Orazio E, Gallia F, Tuccillo F, Terenghi F Chronic inflammatory demyelinating polyradiculoneuropathy and multifocal motor neuropathy:

treatment update. Current Opinion in Neurology 2010; 23(5):519-23 IF: 4,699 152. Joint Task Force of the EFNS and the PNS (Hadden RD, Nobile-Orazio E, Sommer CL, Hahn AF,

Illa I, Morra E, Pollard JD, Lunn MP, Bouche P, Cornblath DR, Evers E, Koski CL, Léger JM, Van den Bergh P, van Doorn PA, van Schaik IN)

European Federation of Neurological Societies/Peripheral Nerve Society Guideline on management of paraproteinemic demyelinating neuropathy: Report of a joint task force of the

European Federation of Neurological Societies and the Peripheral Nerve Society – First Revision Journal of the Peripheral Nervous System 2010; 15: 185-195 IF: 2,258 153. Joint Task Force of the EFNS and the PNS (van Schaik IN, Léger JM, Nobile-Orazio E, Cornblath

DR, Hadden RD, Koski CL, Pollard JD, Sommer C, Illa I, van den Bergh P, van Doorn PA.) European Federation of Neurological Societies/Peripheral Nerve Society Guideline on

management of multifocal motor neuropathy: Report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society – First Revision

Journal of the Peripheral Nervous System 2010; 15: 295-301 IF: 2,258 154. Nobile-Orazio E Update on neuropathies associated with monoclonal gammopathy of undetermined significance (2008–2010) Journal of the Peripheral Nervous System 2010; 15: 301-306 IF: 2,258 155. Pazzaglia C, Briani C, Nobile-Orazio E,Caliandro P, Granata G, Tonali P, Padua L. Occurrence and characterisation of Pain in dysimmune neuropathies: a multicentre prospective study. European Journal of Neurology 2011, 18: 177–183 IF: 3,988 156. Riva N, Iannaccone S, Corbo M, Casellato C, Sferrazza B, Lazzerini A, Scarlato M, Cerri F, Previtali SC, Nobile-Orazio E, Comi G, Quattrini A Motor Nerve Biopsy: Clinical Usefulness and Histopathological Criteria Annals of Neurology 2011; 69: 197-201. IF: 9,890 157. Benedetti L, Briani C, Fazio R, Paolasso I, Comi C, Luigetti M, Sabatelli M, Giannini F, Schenone A,

Nobile-Orazio E, Cocito D. Rituximab in patients with CIDP: A report of 13 cases and review of the literature Journal of Neurology Neurosurgery and Psychiatry 2011; 82: 306-8. IF: 7,349 158. Peters MJH, van Nes SI, Vanhoutte EK, Bakkers M, van Doorn PA, Merkies ISJ, Faber CG; on behalf

of the PeriNomS Study group (Barreira AA, Bennett D, van den Berg LH, van den Bergh PY, Bril V, Cornblath DR, Dalakas M, Devigili G, van Doorn PA, Faber CG, Fisher MA, Gorson KC, Hadden RD, Hahn AF, Hartung HP, Hughes RA, Illa I, Katzberg H, Kieseier BC, van de Kooi AJ, Lauria G, Léger JM, Lewis RA, Lunn MP, Merkies IS, Nobile-Orazio E, Notermans NC, Padua L, Pouget J, Reilly MM, Smith B, de Visser M, Walk D)

Revised normative values for grip strength with the Jamar dynamometer Journal of the Peripheral Nervous System 2011; 16: 47-50 IF: 2,258 159. Nobile-Orazio E, Giannotta C Testing for anti-glycolipid IgM antibodies in chronic immune-mediated demyelinating neuropathies Journal of the Peripheral Nervous System 2011; 16 (Supplement): 18-23 IF: 2,258 160. Cocito D, Grimaldi S, Paolasso I, Falcone Y, Antonini G, Benedetti L, Briani C, Fazio R, Jann S,

Matà S, Sabatelli M, Nobile-Orazio E. Immunosuppressive treatment in refractory chronic inflammatory demyelinating

polyradiculoneuropathy. A nationwide retrospective analysis. European Journal of Neurology 2011; 18: 1417–1421 IF: 3,988 161. Judica E, Nobile-Orazio E Le neuropatie in corso di vasculite e di malattie reumatologiche. Reumatismo 2011; 63: S2:30-33. IF: n.n. 162. Riva N, Gallia F, Iannaccone S, Corbo M, Terenghi F, Lazzerini A, Cerri F, Comi G, Quattrini A,

Nobile-Orazio E. Chronic motor axonal neuropathy Journal of the Peripheral Nervous System 2011; 16: 341-346 IF: 2,258 163. Mazzeo A, Stancanelli C, Russo M, Granata F, Gentile L, Di Leo R, Vita G, Nobile-Orazio E,

Toscano A. Subacute inflammatory demyelinating polyneuropathy disclosed by massive nerve root enhancement

in CMT1A. Muscle and Nerve 2012; 45(3): 451-452 IF: 2,605 164. Umapathi T, Hughes RA, Nobile-Orazio E, Léger JM. Immunosuppressant and immunomodulatory treatments for multifocal motor neuropathy. Cochrane Database of Systematic Review 2012; Apr 18;4:CD003217. IF: 6,264 165. Nobile-Orazio E, Cocito D, Jann S, Uncini A, Beghi E, Messina P, Antonini G, Fazio R, Gallia F,

Schenone A, Francia A, Pareyson D, Santoro L, Tamburin S, Macchia R, Cavaletti G, Giannini F, Sabatelli M, for the IMC Trial Group

Intravenous immunoglobulin versus intravenous methylprednisolone for chronic inflammatory demyelinating polyradiculoneuropathy: a randomised controlled trial.

Lancet Neurology 2012, 11: 493-502. IF. 26,284 166. Vanhoutte EK, Faber CG, Merkies IS and the PeriNomS Study Group (Barreira AA, Bennett D, van

den Bergh PY, Bril V, Devigili G, Hadden RD, Hahn AF, Hartung HP, Hughes RA, Illa I, Katzberg H,

van der Kooi AJ, Léger JM, Lewis RA, Lunn MP, Nobile-Orazio E, Padua L, Pouget J, Reilly MM, van Schaik I, de Visser M.

MRC sum-score in the ICU: good reliability does not necessarily reflect "true reliability". Muscle and Nerve. 2012; May; 45(5):767-8 (Letter) IF: 2,605 167. Lunn MP, Nobile-Orazio E. Immunotherapy for IgM anti-myelin-associated glycoprotein paraprotein-associated peripheral

neuropathies. Cochrane Database of Systematic Reviews. 2012 May 16;5:CD002827. IF: 6,264 168. Vanhoutte EK, Faber CG, van Nes SI, Jacobs BC, van Doorn PA, van Koningsveld R, Cornblath DR,

van der Kooi AJ, Cats EA, van den Berg LH, Notermans NC, van der Pol WL, Hermans MC, van der Beek NA, Gorson KC, Eurelings M, Engelsman J, Boot H, Meijer RJ, Lauria G, Tennant A, Merkies IS; PeriNomS Study Group (Barreira AA, Bennett D, van den Bergh PY, Bril V, Devigili G, Hadden RD, Hahn AF, Hartung HP, Hughes RA, Illa I, Katzberg H, van der Kooi AJ, Léger JM, Lewis RA, Lunn MP, Nascimento OJ, Nobile-Orazio E, Padua L, Pouget J, Reilly MM, van Schaik I, Smith B, de Visser M, Walk D).

Modifying the Medical Research Council grading system through Rasch analyses. Brain 2012;135 :1639-49. IF: 9,890 169. Padua L, Briani C, Truini A, Aprile I, Bouhassirà D, Cruccu G, Jann S, Nobile-Orazio E, Pazzaglia C,

Morini A, Mondelli M, Ciaramitaro P, Cavaletti G, Cocito D, Fazio R, Santoro L, Galeotti F, Carpo M, Plasmati R, Benedetti L, Schenone A.

Consistence and discrepancy of neuropathic pain screening tools DN4 and ID-Pain. Neurological Sciences 2013; 34 (3): 373-7. IF: 1,749 170. Nobile-Orazio E Treatment of chronic immune-mediated neuropathies: Impact of the Rare Diseases Centers network in Italy. Revue Neurologique 2013: 169: S33-S38 IF: 1,039 171. Nobile-Orazio E, Gallia F Multifocal Motor Neuropathy: Current Therapies and Novel Strategies Drugs 2013; 73:397-406 IF: 5,000 172. Nobile-Orazio E, Léger JM, Lewis RA, Bolino A, Shy ME, Cornblath DR. Meeting Report: 2013 Peripheral Nerve Society Biennial Meeting, Saint-Malo, France, June 29–July

3, 2013 (Editorial) Journal of the Peripheral Nervous System 2013; 18: 197–198. IF: 2,258 173. Galeotti F, Massari M, D'Alessandro R, Beghi E, Chiò A, Logroscino G, Filippini G, Benedetti MD,

Pugliatti M, Santuccio C, Raschetti R; ITANG study group (Michelucci R, Riguzzi P, Sacquegna T, Borghi AM, Neurologiche S, Mussuto V, De Massis P, Cirignotta F, Rinaldi R, Neri W, Guidi C, Rosaria M, Granieri E, Simioni V, Nichelli P, Mandrioli J, Guidetti D, Terlizzi E, Terzano MG, Pavesi G, Rasi F, Callegarini C, Marcello N, Bondavalli M, Ravasio A, Curro'Dossi M, Mauro A, Minardi C, Greco G, Amidei S, Montanari E, Medici D, Riccardi T, D'Adda E, Bettoni L, Abruzzi L, Agostoni E, Basso F, Magnoni A, Crespi V, Repaci M, Cheldi A, Bellotti M, Ferrarese C, Curto NA, Meola G, Rotondo G, Nobile-Orazio E, Terenghi F, Sasanelli F, Galbussera A, Mattioli M, Tiriticco Azienda M, Nascimbene C, Vanotti A, Jann S, De Toni Franceschini L, Silani V, Ticozzi N, Comi G, Fazio R, Perrone P, Giorgetti A, Romorini A, Bassi P, Santoro D, Bresolin N, Tonietti S, Suardelli M, Bezzi G, Baldini D, Clerici AM, Cafazzo G, Porazzi D, La Spina I, Grampa G, Zarcone D, Perini M, Poloni M, Agazzi E, Filosto M, Padovani A, Besana R, Donati E, Magni E, Arnaboldi M, Belcastro V, Guidotti M, Riva M, Vitelli E, Previdi P, Micieli G, Candeloro E, Dallocchio C, Arbasino C, Calvo A, Moglia C, Vercellino M, Ferrero B, Pignatta P, Oddenino E, Imperiale D, Leotta D, Gionco M, Ravetti C, Cavallo R, Di Vito N, Geda C, Bortolotto S, Luda di Cortemiglia E, Liotta G, Ursino E, Palermo M, Ambrogio L, Meineri P, Dotta M, Ghiglione P, Maistrelli J, Onorato S, Leone M, Papurello DM, Villani A, Conti R, Coppo F, Tesser F, Testa L, Cattaneo SI, Penza MT, Gusmaroli G, Savio K, Perla F, Mondovı C, Pisano F, Poglio F, Pradotto L, Bottacchi EF, Livrea P, Federico F, Trojano M, Covelli V, Maggio B, Santamato V, Passarella B, Zimatore G, Trianni G, Ciardo G, Interno S, Marchini C, Zambito Marsala S, Michieli G, Borsato C, Didone G, Frasson E, Polo A, Argentiero V, Romeo V, Perlotto N, L'Erario R, Micaglio G, Rosso T, Bruno S, Giometto B, Serena M, Quatrale R, Gastaldo E, Perini F, DiLeone M, Casano A, Silvestri L, Burlina A, Munerati V, D'Anna S, Sanson F, Sartori V, Moretto G, Squintani G, Monaco S, Benedetti MD, Fusina S, Bianconi C, Pimazzoni F, Bonometti A, Zanette G, Turatti M, Leoni S, Mura G, Ticca A, Marchi P, Manca D).

Risk of Guillain-Barré syndrome after 2010-2011 influenza vaccination. European Journal of Epidemiology 2013; 28 (5): 433-44. IF: 7,226 174. Vanhoutte EK, Faber CG, Merkies IS; PeriNomS study group (Van den Bergh P, Bril V, van Doorn

PA, Faber CG, Gorson K, Hahn A, Hughes RA, van der Kooi A, Lauria G, Leger JM, Lewis R, Lunn M, Merkies IS, Nobile-Orazio E, Notermans NC, Querol L, van Schaik I, Zollinger D, Zitterstein A, van Engelen B, Barreira AA, Bennett D, van den Berg P, Cornblath DR, Devigili G, Hadden RD, Illa I, Padua L, Pouget J, Reilly MM, de Visser M, van Nes SI, Walk D.)

196th ENMC international workshop: Outcome measures in inflammatory peripheral neuropathies 8-10 February 2013, Naarden, The Netherlands.

Neuromuscular Disorders 2013; 23(11): 924-33. IF: 2,969 175. Nobile-Orazio E, Giannotta C, Musset L, Messina P, Léger JM Sensitivity and predictive value of anti-GM1/galactocerebroside IgM antibodies in multifocal motor

neuropathy. Journal of Neurology Neurosurgery and Psychiatry 2014; 85: 754-758 IF: 7,349 176. Nobile-Orazio E.

Chronic Inflammatory demyelinating polyradiculoneuropathy. Where we are, where we should go. Journal of the Peripheral Nervous System 2014; 19: 2-13 IF: 2,258

177. Di Fonzo A, Ronchi D, Gallia F, Cribiù FM, Trezzi I, Vetro A, Della Mina E, Limongelli I, Bellazzi R, Ricca I, Micieli G, Fassone E, Rizzuti M, Bordoni A, Fortunato F, Salani S, Mora G, Corti S, Ceroni M, Bosari S, Zuffardi O, Bresolin N, Nobile-Orazio E, and Comi G.

Lower motor neuron disease with respiratory failure caused by a novel MAPT mutation. Neurology 2014; 82; 1990-1998 IF: 8,320

178. Nobile-Orazio E Treatment dependence in chronic inflammatory demyelinating polyradiculoneuropathy: is it related to

disease phenotype or to the therapy used? (Editorial) Journal of Neurology Neurosurgery and Psychiatry 2014; 85: 829 IF: 7,349

179. Cocito D, Merola, Peci E, Toscano A, Fazio R, Francia A, Valentino P, Liguori R, Filosto M, Siciliano G, Bono G, Lelli S, Marfia GA, Antonini G, Cecconi I, Nobile-Orazio E, Lopiano L.

Subcutaneous immunoglobulin in CIDP and MMN: a short-term nationwide study Journal of Neurology 2014, 261(11): 2159-64 IF: 3,389 180. Draak T, Vanhoutte EK, van Nes S, Gorson KC, van der Pol L, Notermans L, Nobile-Orazio E, Léger

J-M, Van den Bergh P, Lauria G, Bril V, Katzberg H, Lunn M, Pouget J, van der Kooi A, Hahn A, van Doorn P, Cornblath D, van den Berg L, Faber C, Merkies IDJ.

Changing outcome in inflammatory neuropathies: Rasch–comparative responsiveness Neurology 2014; 83(23): 2124-32. IF: 8,320 181. Notturno F, Di Febo T, Fernandez Rodriguez BM, Corti D, Yuki N, Nobile-Orazio E, Carpo M, De

Lauretis A, Uncini A. Antibodies to neurofascin 186 and gliomedin in multifocal motor neuropathy Journal of Neuroimmunology 2014; 276 (1-2): 207-12. IF: 2,720 182. Nobile-Orazio E, Lewis RA 7th International Immunoglobulin Conference: Neurology (Meeting Report) Clinical and Experimental Immunology 2014, 178: 22-24 IF: 3,410 183. Nobile-Orazio E, Lewis RA 7th International Immunoglobulin Conference: Neurologyy Summary (Meeting Report) Clinical and Experimental Immunology 2014; 178: 45 IF: 3,410 184. Nobile-Orazio E, Cocito D, Jann S, Uncini A, Messina P, Antonini G, Fazio R, Gallia F, Schenone A,

Francia A, Pareyson D, Santoro L, Tamburin S, Cavaletti G, Giannini F, Sabatelli M, Beghi E, for the IMC Trial Group

Frequency and time to relapse after discontinuing 6-month therapy with IVIg or pulsed methylprednisolone in CIDP

Journal of Neurology Neurosurgery and Psychiatry 2015, 86:729-34 IF: 7,349 185. Giannotta C, Di Pietro D, Gallia F, Nobile-Orazio E Anti-sulfatide IgM antibodies in peripheral neuropathy: to test or not to test? European Journal of Neurology 2015; 22: 879-882 IF: 3,988 186. Stork AC, Lunn MPT, Nobile-Orazio E, Notermans NC Treatment for IgG and IgA paraproteinemic neuropathy. Cochrane Database of Systematic Reviews 2015 Mar 24;3:CD005376. IF: 6,264

187. Umapathi T, Hughes RA, Nobile-Orazio E, Léger JM. Immunosuppressant and immunomodulatory treatments for multifocal motor neuropathy. Cochrane Database of Systematic Review 2015 Mar 4;3:CD003217. IF: 6,264 188. Cocito D, Merola A, Romagnolo A, Peci E, Toscano A, Mazzeo A, Gentile L, Russo M, Fazio F,

Filosto M, Siciliano G, Schirinzi E, Nobile-Orazio E, Lopiano L. Subcutaneous immunoglobulin in CIDP and MMN: a different long-term clinical response? Journal of Neurology Neurosurgery and Psychiatry 2015 Jun 24. pii: jnnp-2014-310280. [Epub ahead

of print] IF: 7,349 189. Nobile-Orazio E, Gallia F Update on the treatment of chronic inflammatory demyelinating polyradiculoneuropathy.

Current Opinion in Neurology 2015; 28: 480-5. IF: 4,699 190. Draak THP, Pruppers MHJ, van Nes SI, Vanhoutte EK, Bakkers B, Gorson KC, Van der Pol WL,

Notermans NC, Nobile-Orazio E, Léger J-M, Van den Bergh PYK, Lauria G, Bril V, Katzberg H, Lunn MPT, Pouget J, van der Kooi AJ, van den Berg LH, van Doorn PA, Cornblath DR, Hahn AF, Faber KG, Merkies ISJ on behalf of the PeriNomS study group

Grip strength comparison in immune-mediated neuropathies: Vigorimeter versus Jamar Journal of the Peripheral Nervous System 2015; 20.: 269-276. IF: 2,258

191. Draak THP, Vanhoutte EK, van Nes SI, Gorson KC, Van der Pol WL, Notermans NC, Nobile-Orazio E, Léger J-M, Van den Bergh PYK, Lauria G, Bril V, Katzberg H, Lunn MPT, Pouget J, van der Kooi AJ, Hahn AF, van den Berg LH, van Doorn PA, Cornblath DR, Faber KG, Merkies ISJ, on behalf of the PeriNomS study group

Comparing the NIS vs MRC and INCAT sensory scale through Rasch analyses Journal of the Peripheral Nervous System 2015; 20: 277-286 IF: 2,258

192. Vanhoutte EK, Draak THP, Gorson KG, van Nes SI, Hoeijmakers JGJ, Van der Pol WL, Notermans NC, Nobile-Orazio E, Léger J-M, Van den Bergh PYK, Lauria G, Bril V, Katzberg H, Lunn MPT, Pouget J, van der Kooi AJ, Hahn AF, van Doorn PA, Cornblath DR, van den Berg LH, Faber CG, Merkies ISJ, on behalf of the PeriNomS study group.

Impairment measures versus inflammatory-RODS in GBS and CIDP: A responsiveness comparison Journal of the Peripheral Nervous System 2015; 20: 289-295. IF: 2,258

193. Pruppers MHJ, Draak THP, Vanhoutte EK, Van der Pol WL, Gorson KC, Léger J-M, Nobile-Orazio E, van den Berg LH, Faber CG, Merkies ISJ, on behalf of the PeriNomS study group.

Outcome measures in MMN revisited: further improvement needed Journal of the Peripheral Nervous System 2015; 20: 306-318 IF: 2,258

194. Vanhoutte EK, Hermans MCE, Faber CG, Gorson KC, Merkies IS;Thonnard J-L., PeriNomS Study Group (Barreira AA, Bennett D, van den Berg LH, Van den Bergh PY, Bombelli F, Bril V, Campanella A, Cats A, Cornblath DR, Costa R, Devigili G, van Doorn PA, Faber CG, Franques J, Gallia F, Gorson KC, Hadden RD, Hahn AF, Hughes RA, Illa I, Katzberg H, van der Koi AJ, Lauria G, Léger JM, Lewis RA, Lunn MP, , van der Kooi AJ, Merkies IS, van Nes SI , Nobile-Orazio E, Notermans NC, Padua L, Pouget J, Querol L, Raaphorts J, Reilly MM, van Schaik IN, de Visser M)

Rasch-ionale for Neurologists. Journal of the Peripheral Nervous System 2015; 20: 260-268 IF: 2,258 195. Vanhoutte EK, Faber CG, van Nes SI, Cats EA, Van der Pol WL, Gorson KC, van Doorn PA,

Cornblath DR, van den Berg LH, Merkies IS; PeriNomS Study Group (Barreira AA, Bennett D, Hadden RD, Hughes RA, Lunn MP, Reilly MM, van den Berg LH, van Doorn PA, Faber CG, van der Kooi AJ, Merkies IS, Notermans NC, Raaphorts J, van Schaik IN, de Visser M, Cats EA, Van den Bergh PY, Bombelli F, Costa R, Franques J, Léger JM, Pouget J, Bril V, Hahn AF, Katzberg H, Campanella A, Devigili G, Gallia F, Lauria G, Nobile-Orazio E, Padua L, Cornblath DR, Gorson KC, Lewis RA, Illa I, Querol L, van Nes SI)

Rasch-built Overall Disability Scale for Multifocal motor neuropathy (MMN-RODS© ).. Journal of the Peripheral Nervous System 2015; 20: 296-305 IF: 2,258 196. Benedetti MD, Pugliatti M, D'Alessandro R, Beghi E, Chiò A, Logroscino G, Filippini G, Galeotti F,

Massari M, Santuccio C, Raschetti R; ITANG Study Group (Abruzzi L, Agazzi E, Agostoni E, Ambrogio L, Amidei S, Arbasino C, Argentiero V, Arnaboldi M, Baldini D, Barki R, Bassi P, Basso F, Belcastro V, Bellotti M, Bersano E, Besana R, Bettoni L, Bezzi G, Bianconi C, Bondavalli M, Bonometti A, Borghi AM, Borsato C, Bortolotto S, Bottacchi EF, Bresolin N, Bruno S, Burlina A, Cafasso G, Callegarini C, Calvo A, Candeloro E, Casano A, Cattaneo SI, Cavallo R, Cheldi A, Ciardo G, Cirignotta F, Clerici AM, Clerici R, Comi G, Conti R, Coppo F, Covelli V, Crespi V, Currò Dossi

M, Curtò NA, D'Adda E, Dallocchio C, D'Anna S, De Massis P, De Toni Franceschini L, Di Vito N, Didonè G, Dileone M, Donati E, Dotta M, Fazio R, Federico F, Ferrarese C, Ferrazzini F, Ferrero B, Filosto M, Frasson E, Fusina S, Galbussera A, Gastaldo E, Geda C, Ghiglione P, Giometto B, Gionco M, Giorgetti A, Giussani G, Gobbin F, Grampa G, Granieri E, Greco G, Guidetti D, Guidi C, Guidotti M, Gusmaroli G, Imperiale D, Internò S, Jann S, La Spina I, Leo A, Leone M, Leoni S, Leotta D, Lerario R, Liotta G, Livrea P, Luda di Cortemiglio E, Maggio B, Magni E, Magnoni A, Maistrelli J, Manca D, Mandrioli J, Manera U, Marcello N, Marchi P, Marchini C, Marconi S, Mattioli M, Mauro A, Mazzaglia G, Medici D, Meineri P, Meola G, Micaglio G, Michelucci R, Michieli G, Micieli G, Minardi C, Moglia C, Monaco S, Montanari E, Moretto G, Munerati V, Mura G, Mussutto V, Nascimbene C, Neri W, Nichelli P, Nobile-Orazio E, Oddenino E, Onorato S, Padovani A, Palermo M, Papurello DM, Passarella B, Pavesi G, Penza MT, Perini M, Perini F, Perla F, Perlotto N, Perrone P, Pignatta P, Pisano F, Poglio F, Polo A, Poloni M, Porazzi D, Pradotto L, Previdi P, Quatrale R, Rasi F, Ravasio A, Ravetti C, Repaci M, Riccardi T, Riguzzi P, Rinaldi R, Riva M, Romeo V, Romorini A, Rosso T, Rotondo G, Sacquegna T, Sanson F, Santamato V, Santoro D, Sartori V, Sasanelli F, Savio K, Serena M, Silani V, Silvestri L, Simioni V, Squintani GM, Suardelli M, Tartagla L, Terenghi F, Terlizzi E, Terzano MG, Tesser F, Testa L, Ticca A, Ticozzi N, Tiriticco M, Tola MR, Tonietti S, Trianni G, Trojano M, Trotta F, Turatti M, Ursino E, Vanotti A, Vercellino M, Villani A, Vitelli E, Zambito Marsala S, Zanette G, Zarcone D, Zimatore G, Zoccolella S.

A Multicentric Prospective Incidence Study of Guillain-Barré Syndrome in Italy. The ITANG Study. Neuroepidemiology 2015; 45(2): 90-9 IF: 2,886 197. Gallia F, Balducci C, Nobile-Orazio E Efficacy and tolerability of different brands of intravenous immunoglobulin in the maintenance

treatment of chronic immune mediated neuropathies Journal of the Peripheral Nervous System 2016 ; 21(2): 82-4 IF: 2,258 198. Draak TH, Gorson KC, Vanhoutte EK, van Nes SI, van Doorn PA, Cornblath DR, van den Berg LH,

Faber CG, Merkies IS; PeriNomS Study Group (Barreira AA, Bennett D, van den Berg LH, Van den Bergh PY, Bombelli F, Bril V, Campanella A, Cats EA, Cornblath DR, Costa R, Devigili G, van Doorn PA, Faber CG, Franques J, Gallia F, Gorson KC, Hadden RD, Hahn AF, Hughes RA, Illa I, Katzberg H, van der Kooi AJ, Lauria G, Léger JM, Lewis RA, Lunn MP, Merkies IS, van Nes SI, Nobile-Orazio E, Notermans NC, Padua L, Van der Pol WL, Pouget J, Querol L, Raaphorst J, Reilly MM, van Schaik IN, de Visser M).

Does ability to walk reflect general functionality in inflammatory neuropathies? Journal of the Peripheral Nervous System 2016; 21 (2): 74-81. IF: 2,258 199. Draak TH, Gorson KC, Vanhoutte EK, van Nes SI, van Doorn PA, Cornblath DR, van den Berg LH,

Faber CG, Merkies IS; PeriNomS Study Group (Barreira AA, Bennett D, Van den Bergh PY, Bombelli F, Bril V, Campanella A, Cats EA, Costa R, Devigili G, Franques J, Gallia F, Hadden RD, Hahn AF, Hughes RA, Illa I, Katzberg H, van der Kooi AJ, Lauria G, Léger JM, Lewis RA, Lunn MP, Nobile-Orazio E, Notermans NC, Padua L, Ludo Van der Pol W, Pouget J, Querol L, Raaphorst J, Reilly MM, van Schaik IN, de Visser M.)

Correlation of the patient's reported outcome Inflammatory-RODS with an objective metric in immune-mediated neuropathies.

European Journal of Neurology 2016; 23(7): 1248-1253 IF: 3,988 200. Lunn MP, Nobile-Orazio E. Immunotherapy for IgM anti-myelin-associated glycoprotein paraprotein-associated peripheral

neuropathies. Cochrane Database Syst Rev. 2016 October 4; 10:CD002827. IF: 6,264 201. Riva N, Clarelli F, Domi T, Cerri F, Gallia F, Trimarco A, Brambilla P, Lunetta C, Lazzerini A,

Lauria G, Taveggia C, Iannaccone S, Nobile-Orazio E, Comi G, D'Antonio M, Martinelli Boneschi F, Quattrini A.

Unraveling gene expression profiles in peripheral motor nerve from Amyotrophic Lateral Sclerosis patients: insights into pathogenesis

Scientific Reports 2016 Dec 16; 6:39297. doi: 10,2928/srep39297 IF: 4,259 202. Nobile-Orazio E, Cocito D, Briani C, Plasmati R, Schenone A, Gallia F, Marjanovic I, Lotti Suffredini

A. High-dose Ig VENA is well tolerated and efficacious in patients with multifocal motor neuropathy Neurological Sciences 2017; 38(5): 899-902. IF: 1,749

203. Campagnolo M, Zambello R, Nobile-Orazio E, Benedetti L, Marfia GA, Riva N, Castellani F, Bianco M, Salvalaggio A, Garnero M, Ruiz M, Mataluni G, Fazio R, Ermani M, Briani C. IgM MGUS and Waldenstrom-associated anti-MAG neuropathies display similar response to rituximab therapy.

Journal of Neurology Neurosurgery and Psychiatry 2017, Dec; 88(12):1094-1097 IF: 7,349 204. Nobile-Orazio E, Gallia F, Terenghi F, Bianco, M Comparing treatment options for chronic inflammatory neuropathies and choosing the right treatment

plan. Expert Review of Neurotherapeutics 2017 Aug;17(8):755-765, doi: 10.1080/14737175.2017.1340832.

IF: 3,149 205. Clerici AM, Nobile-Orazio E, Mauri M, Squellati FS, Bono GG.

Utility of somatosensory evoked potentials in the assessment of response to IVIG in along-lasting case of chronic immune sensory polyradiculopathy. 1

BMC Neurology 2017: 17:127. DOI 10.1186/s12883-017-0906-2 IF: 2.006 206. Jacobs BC, van den Berg B, Verboon C, Chavada G, Cornblath DR, Gorson KC, Harbo T, Hartung

HP, Hughes RAC, Kusunoki S, van Doorn PA, Willison HJ; IGOS Consortium (van Woerkom M, Roodbol J, Reisin RC, Reddel SW, Islam Z, Islam B, Mohammad QD, Feasby TE, Wang YZ, T, Péréon Y, Lehmann HC, Dardiotis E, Nobile-Orazio E, Shahrizaila N, Verboon C, Bateman K, Illa I, Querol LA, Hsieh ST, Chavada G, Davidson A, Addington JM, Ajroud-Driss S, Andersen H, Antonini G, Attarian S, Badrising U, Barroso FA, Benedetti L, Beronio A, Bianco M, Binda D, Briani C, Bürmann J, Bella IR, Bertorini TE, Bhavaraju-Sanka R, Brannagan TH, Busby M, Butterworth S, Campagnolo M, Casasnovas C, Cavaletti G, Chao CS, Chen S, Chetty S, Claeys KG, Cohen JA, Conti ME, Cosgrove JS, Dalakas MC, Dimachkie MM, Dillmann U, Domínguez González C, Doppler K, Dornonville de la Cour C, Echaniz-Laguna A, Eftimov F, Faber CG, Fazio R, Fokke C, Fujioka T, Fulgenzi EA, Galassi G, Garcia T, Garnero M, Garssen MPJ, Gijsbers CJ, Gilchrist JM, Gilhuis HJ, Goldstein JM, Goyal N, Granit V, Grapperon A, Gutiérrez Gutiérrez G, Gutmann L, Hadden RDM, Holbech JV, Holt JKL, Homedes Pedret C, Htut M, Jellema K, Jericó Pascual I, Kaida K, Karafiath S, Katzberg HD, Kiers L, Kieseier BC, Kimpinski K, Kleyweg RP, Kokubun N, Kolb NA, Kuitwaard K, Kuwabara S, Kwan JY, Ladha SS, Landschoff Lassen L, Lawson V, Ledingham D, Léon Cejas L, Luciano CA, Lucy ST, Lunn MPT, Magot A, Manji H, Marchesoni C, Marfia GAM, Márquez Infante C, Martinez Hernandez E, Mataluni G, Mattiazi M, McDermott CJ, Meekins GD, Miller J, Monges MS, Montero MCJ, Morís de la Tassa G, Nascimbene C, Neumann C, Nowak RJ, Orizaola Balaguer P, Osei-Bonsu M, Pan EBL, Pardo Fernandez J, Pasnoor M, Pulley MT, Rajabally YA, Rinaldi S, Ritter C, Roberts RC, Rojas-Marcos I, Rudnicki SA, Sachs GM, Samijn JPA, Santoro L, Saperstein DS, Savransky A, Schneider H, Schenone A, Sedano Tous MJ, Sekiguchi Y, Sheikh KA, Silvestri NJ, Sindrup SH, Sommer CL, Stein B, Stino AM, Spyropoulos A, Srinivasan J, Suzuki H, Taylor SW, Tankisi H, Tigner D, Twydell PT, Valzania F, van Damme P, van der Kooi AJ, van Dijk GW, van der Ree T, van Koningsveld R, Varrato JD, Vermeij FH, Verschuuren JJGM, Visser LH, Vytopil MV, Waheed W, Wilken M, Wilkerson C, Wirtz PW, Yamagishi Y, Yiu EM, Zhou L, Zivkovic S... International Guillain-Barré Syndrome Outcome Study: protocol of a prospective observational cohort study on clinical and biological predictors of disease course and outcome in Guillain-Barré syndrome. Journal of the Peripheral Nervous System 2017 Jun;22(2): 68-76 IF: 2.361

207. Boso F, Ruggero S, Giannotta C, Benedetti L, Marfia GA, Ermani M, Campagnolo M, Salvalaggio A, Gallia F, De Michelis C,

Visentin A, Bianco M, Ruiz M, Mataluni G, Nobile-Orazio E, Briani C. Anti-sulfatide/galactocerebroside antibodies in IgM paraproteinemic neuropathies European Journal of Neurology 2017; 24(11):1334-1340. doi:10.1111/ene.13387 IF: 3,988 208. Nozza A, Terenghi F, Gallia F, Adami F, Briani C, Merlini G, Giordano L, Santoro A, Nobile-Orazio

E. Lenalidomide and dexamethasone in patients with POEMS syndrome: results of a prospective, open-label trial. British Journal of Haematology 2017; 179(5):748-755. doi: 10.1111/bjh.14966. IF: 5,670

209. Nobile-Orazio E, Bianco M, Nozza A. Advances in the Treatment of Paraproteinemic Neuropathy Current Treatment Options in Neurology 2017 Oct 16;19(12):43. doi: 10.1007/s11940-017-0479-9. Review. IF: 2,383

210. Gastaldi M, Zardini E, Leante R, Ruggieri M, Costa G, Cocco E, De Luca G, Cataldo I, Biagioli T, Ballerini C, Castellazzi M, Fainardi E, Pettini P, Zaffaroni M, Giunti D, Capello E, Bernardi G,

Ciusani E, Giannotta C, Nobile-Orazio E, Bazzigaluppi E, Passerini G, Bedin R, Sola P, Brivio R, Cavaletti G, Sala A, Bertolotto A, Desina G, Leone MA, Mariotto S, Ferrari S, Paternoster A, Giavarina D, Lolli F, Franciotta D.

Cerebrospinal fluid analysis and the determination of oligoclonal bands. Neurological Sciences 2017; 38(Suppl 2): 217-224. doi: 10.1007/s10072-017-3034-2. IF: 1,749

211. Zoccarato M, Gastaldi M, Zuliani L, Biagioli T, Brogi M, Bernardi G, Corsini E, Bazzigaluppi E, Fazio R, Giannotta C, Nobile-Orazio E, Costa G, Iorio R, Evoli A, Mariotto S, Ferrari S, Galloni E, De Riva V, Zardini E, Franciotta D, Giometto B.

Diagnostics of paraneoplastic neurological syndromes. Neurological Sciences 2017; 38(Suppl 2): 237-242. doi: 10.1007/s10072-017-3031-5. IF: 1,749

212. Zuliani L, Zoccarato M, Gastaldi M, Iorio R, Evoli A, Biagioli T, Casagrande S, Bazzigaluppi E, Fazio R, Giannotta C, Nobile-Orazio E, Andreetta F, Simoncini O, Costa G, Mariotto S, Ferrari S, Galloni E, Marcon M, Franciotta D, Giometto B. Diagnostics of autoimmune encephalitis associated with antibodies against neuronal surface antigens. Neurological Sciences 2017; 38(Suppl 2): 225-229. doi: 10.1007/s10072-017-3032-4. IF: 1,749

213. Franciotta D, Gastaldi M, Benedetti L, Pesce G, Biagioli T, Lolli F, Costa G, Melis C, Andreetta F, Simoncini O, Giannotta C, Bazzigaluppi E, Fazio R, Bedin R, Ferraro D, Mariotto S, Ferrari S, Galloni E, De Riva V, Zardini E, Cortese A, Nobile-Orazio E. Diagnostics of dysimmune peripheral neuropathies. Neurological Sciences 2017; 38(Suppl 2): 243-247. doi: 10.1007/s10072-017-3025-3. IF: 1,749

214. Franciotta D, Gastaldi M, Benedetti L, Garnero M, Biagioli T, Brogi M, Costa G, Fadda E, Andreetta F, Simoncini O, Giannotta C, Bazzigaluppi E, Fazio R, Bedin R, Ferraro D, Mariotto S, Ferrari S, Galloni E, De Riva V, Zardini E, Cortese A, Nobile-Orazio E. Diagnostics of anti-MAG antibody polyneuropathy. Neurological Sciences 2017; 38(Suppl 2): 249-252. doi: 10.1007/s10072-017-3024-4. IF: 1,749

215. Pruppers MHJ, Merkies IDJ, Lunn MPT, Notermans NC, on behalf of the IMAGiNe study group (van den Bergh P, Blomkwist-Markens P, Cornblath D, D’Sa S, Faber C, Goedee S, Gorson K, Léger J-M, Lewis R, Lunn M, Mazawey L, Merkies I, Nobile-Orazio E, Notermans N, Padua L, van der Pol L, Pruppers M)

230 th ENMC international workshop: Improving future assessment and research in IgM anti-MAG peripheral neuropathy: a consensus collaborative effort. Naarden, The Netherlands, 24-26/02/2017

Neuromuscular Disorders 2017; Nov;27(11): 1065-1072. IF: 2,969 216. Draak THP, Faber CG, Merkies ISJ; PeriNomS study Group. Barreira AA, Bennett D, Van Den Berg

LH, Van Den Bergh P, Bombelli F, Bril V, Campanella A, Cats EA, Cornblath DR, Costa R, Devigili G, Van Doorn PA, Faber CG, Franques J, Gallia F, Gorson KC, Hadden RD, Hahn AF, Hughes R, Illa I, Katzberg H, Van Der Kooi AJ, Lauria G, Léger JM, Lewis RA, Lunn M, Merkies I, Van Nes SI, Nobile-Orazio E, Notermans NC, Padua L, Pouget J, Querol L, Raaphorst J, Reilly MM, Van Schaik IN, De Visser M.

Quality of life in inflammatory neuropathies: the IN-QoL Journal of Neurology Neurosurgery Psychiatry 2018; 89: 256-262. doi: 10.1136/jnnp-2017-316634.

IF: 7,349 217. Eftimov F, Bunschoten C, Rajabally Y, Querol L; participants of the 231st ENMC workshop

(Adrichem ME, Allen J, Antoine JC, Basta I, Van den Bergh P, Blomkwist-Markens P, Breukel A, Bunschoten C, Cornblath D, Doppler K, Eftimov F, Goedee S, Hadden R, Harbo T, Hiew FL, Jacobs BC, Lehmann H, Lunn MP, Merkies ISJ, Nobile-Orazio E, Querol L, Rajabally Y, Reddel S, Vallat JM, Uncini A) 231st ENMC International Workshop:: International Standard for CIDP Registry and Biobank, Naarden, The Netherlands, 12-14 May 2017. Neuromuscular Disorders 2018; 28(2): 178-184. doi: 10.1016/j.nmd.2017.10.009. IF: 2,969

218. Franciotta D, Gastaldi M, Zardini E; Nobile-Orazio E Cerebrospinal fluid total protein determination in acute and chronic inflammatory demyelinating polyneuropathies: A critical reappraisal Journal of the Peripheral Nervous System 2018; 23: 70-72 ; DOI: 10.1111/jns.12253IF: 2,258

219. Nobile-Orazio E Complement story in GBS: from pathogenesis to possible therapy. Lancet Neurology 2018; 17:483-485. doi: 10.1016/S1474-4422(18)30144-3 (Commentary)IF: 26,284

220. Franciotta D, Gastaldi M, Biagioli T, Benedetti L, Giannotta C, Bedin R, Zardini N, Nobile-Orazio E.

Anti-ganglioside antibodies: experience from the Italian Association of Neuroimmunology external quality assessment scheme.

Clinical Chemistry and Laboratory Medicine 2018; doi: 10.1515/cclm-2018-0234. [Epub ahead of print] IF: 3,432

221. Hughes R, Dalakas M, Merkies I, Latov N, Léger J-M, Nobile-Orazio E, Sobue G, Genge A, Cornblath D, Merschhemke M, Marie EC, Agoropoulou C, Hartung H-P.

Randomized controlled trial of oral fingolimod in chronic inflammatory demyelinating polyradiculoneuropathy (FORCIDP trial).

Lancet Neurology 2018; 17(8):689-698. IF: 26,284 222. van Lieverloo GGA, Stojan P, Doneddu P, Gallia F, Nikolic A, Luuk W, Verhamme C, van Schaik I,

Nobile-Orazio E, Basta I, Eftimov F. Corticosteroids in Chronic Inflammatory Demyelinating Polyneuropathy. A retrospective, multicentre

study, comparing efficacy and safety of daily prednisolone, pulsed dexamethasone and pulsed intravenous methylprednisolone.

Journal of Neurology 2018; 265 (9): 2052-2059 IF: 3,389 223. Doets A, Verboon C, van den Berg B, Harbo T, Cornblath D, Willison H, Attarian S, Barroso F,

Bateman K,Benedetti L, van den Bergh P, Casasnovas C, Cavaletti G, Chavada G, Claeys K, Dardiotis E, Davidson A, van Doorn P, Feasby T, Pardo J, Galassi G, Gorson K, Hartung H-P, Hshieh S-T, Hughes R, Illa I, Islam B, Kusunoki S, Kuwabara S, Lehmann H, Miller J, Monges S, Nobile-Orazio E, Pereon Y, Rinaldi S, Querol L, Reddel S, Reisin R, Shahrizaila N, Sindrup S, Waqar W, Jacobs B, for the IGOS consortium.

Regional variation of Guillain-Barré syndrome. IF: 10,292 Brain 2018: 141(10): 2866-2877. 224. Doneddu PE, Nobile-Orazio E. Management of Chronic Inflammatory Demyelinating Polyradiculopathy

Current Opinion in Neurology 2018; 31(5): 511-516. IF: 4,699 225. Bianco M, Terenghi F, Gallia F, Nozza A, Scarale A, Fayoumi MZ, Giannotta C, Nobile-Orazio E. Clinical, electrophysiological and VEGF 2-year response after lenalidomide or stem cell

transplantation in patients with POEMS syndrome J Neurol Neurosurg Psychiatry. 2018 Jun 26. pii: jnnp-2018-317949. doi: 10.1136/jnnp- 2018-

317949. [Epub ahead of print] IF: 7,349 226. Falzone YM, Campagnolo M, Bianco M, Dacci P, Martinelli D, Ruiz M, Bocci S, Cerri F, Quattrini A,

Comi G, Benedetti L, Giannini F, Lauria G, Nobile-Orazio E, Briani C, Fazio R, Riva N. Functioning and quality of life in patients with neuropathy associated with anti-MAG antibodies Journal of Neurology 2018, Oct 10. doi: 10.1007/s00415-018-9081-7. [Epub ahead of print] IF: 3,389 227. Doneddu PE, Cocito D, Manganelli F, Fazio R, Briani C, Filosto M, Benedetti L, Mazzeo A, Marfia

GA, Cortese A, Fierro B, Jann S, Beghi E, Clerici AM, Carpo M, Schenone A, Luigetti M, Lauria G, Antonini G, Rosso T, Siciliano G, Cavaletti G, Liberatore G, Santoro L, Peci E, Tronci S, Ruiz M, Cotti Piccinelli S, Toscano A, Mataluni G, Piccolo L, Cosentino G, Sabatelli M, Nobile-Orazio E;

Atypical CIDP: diagnostic criteria, progression and treatment response. Data from the Italian CIDP Database.

Journal of Neurology Neurosurgery and Psychiatry 2018 Oct 8. pii: jnnp-2018-318714. doi: 10.1136/jnnp-2018-318714. [Epub ahead of print] IF: 7,349

228. Léger JM, Alfa-Cissé O, Cocito D, Grouin JM, Katifi H, Nobile-Orazio E, Ouaja R, Pouget J, Rajabally YA, Sevilla Mantecon T, Merkies I

IqYmune® is an effective maintenance treatment for multifocal motor neuropathy: a randomised, double-blind, multicenter cross-over non-inferiority study versus Kiovig® - The LIME Study Journal of the Peripheral Nervous System 2018 (in press) IF: 2,258

b) Capitoli su libri o relazioni pubblicate in esteso su libri 1. Nobile-Orazio E. Immunofissazione: principi generali e applicazione alla elettroforesi del liquido cerebrospinale. In: L'analisi diagnostica del liquor. Tavolato B e Livrea G (eds). Piccin Padova, 1983: 123-132. 2. Latov N, Nobile-Orazio E.

The myelin-associated glycoprotein in demyelinating diseases. In: Multiple Sclerosis: Present and Future. Aloisi C, Matthews WB e Scarlato G (eds). Plenum Press.

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CIC Edizion Internazionali, Roma. 1996: 100-106 9. Meucci N, Barbieri S, Cappellari A, Allaria S, Scarlato G, Nobile-Orazio E. Long term follow-up of multifocal motor neuropathy patients treated with intravenous immunoglobulin

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1997: 149-159. 11. Nobile-Orazio E. Neuropathies associated with anti-MAG antibodies and IgM monoclonal gammopathies. In: Immunological and infectious diseases of the peripheral Nerve. Latov N, Wokke JHJ, Kelly JJ,(eds).

Cambridge University Press, Cambridge, UK 1998: pp169-189. 12. Nobile-Orazio E, Carpo M. Immunopathogenetic role of anti-neural antibodies in demyelinating dysimmune neuropathies. In: From basic immunology to immune-mediated demyelination. Martino G, Adorini L (eds). Springer&

Verlag Italia, Milano 1999: pp 274-286. 13. Nobile-Orazio E, Cappellari A. Paraneoplastic motor neuron disease. In: Handbook of Clinical Neurophysiology Vol. 4: Clinical Neurophysiology of Motor neuron Diseases.

Eisen A. (ed). Elsevier Science BV. Amsterdam (NL) 2004. pp 569-582 14. Nobile-Orazio E, Terenghi F, Bersano A Sindrome di Guillain-Barré e altre neuropatie immunomediate. In. Trattato di Neuropatologia. Mancardi GL, Tagliavini F, Vita (eds). AINP Associazione Italiana di

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Multifocal motor neuropathy. In: European Handbook of Neurological Management, Vol. 1. 2nd Edition. Gilhus NE, Barnes M,

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ALL. C ATIIVITA EDITORIALE E INCARICHI IN SOCIETA’ SCIENTIFICHE

REVISORE AD HOC

Journal of Neurology, Neurosurgery and Psychiatry, London, UK Revue Neurologique, Paris, Francia. Journal of Neurology, Amsterdam, Olanda. Journal of the Neurological Sciences, Amsterdam, Olanda European Journal of Neurology, Oxford, UK Journal of the Peripheral Nervous System, NY, USA Muscle & Nerve, USA Neuromuscular Disorders, London, UK (Italian Journal of the) Neurological Sciences, Milano, Italia Journal of Neuroimmunology, USA Journal of Neurochemistry, USA Brain, London, UK Neurology, USA Clinical Neurophysiology Annals of Neurology, USA Nature Clinical Practice Neurology, UK Lancet Neurology, UK Nature Reviews in Neurology, UK AIFA, Italia Ministero della Salute, Italia

PREMI E INCARICHI DIRETTIVI IN SOCIETA’ SCIENTIFICHE 1980-1981 Premio di Studio "Devisart" per l'estero Universita' di Milano. 1993-1996 Membro del Comitato Direttivo dell’Associazione Italiana di Neuropatologia. 1997-2010 Membro del Comitato Scientifico del Gruppo Italiano di Studio delle Neuropatie Periferiche 2001-2005 Coordinatore del Gruppo Italiano di Studio delle Neuropatie Periferiche 1998-2003 Membro del Comitato Direttivo dell’ Associazione Italiana di Neuroimmunologia 2001-2005 Membro dell’Executive Commitee dell’European Neurological Society (dal 2003 al 2005

Director of the Teaching Courses) 2003-2007 Membro del Board of Director della Peripheral Nerve Society 2007-2011 Chairman del Guideline Committee della Peripheral Nerve Society 2005- Membro dell’Organizing Committee dell’Inflammatory Neuropathy Consortium (INC) della

Peripheral Nerve Society 2009-2011 President Elect della Peripheral Nerve Society 2011-2013 President della Peripheral Nerve Society 2013-2015 Past-President Peripheral Nerve Society 2013-2017 Chair dell’Educational Committee, Peripheral Nerve Society 2017- Membro dell’Educational Committee, Peripheral Nerve Society 2013- Membro del Medical Advisory Board dell GBS-CIDP Foundation International AFFILIAZIONE A SOCIETA' 1989-1999 Associazione Italiana di Neuropatologia 1988-2005 Gruppo Italiano di Neuroimmunologia (Ass. Italiana di Neuroimmunologia) 1989- European Neurological Society 1991- Società Italiana di Neurologia 1994- Peripheral Nerve Society 1996- Gruppo di Studio (ora Associazione) sul Sistema Nervoso Periferico. 1998- American Academy of Neurology, Correspondig Fellow 2012- American Neurological Association, Correspondig Fellow