Ministero della Salute...peritoneal mesothelioma ISTITUTO TUMORI MILANO BIO Oncology 2 ‐...

Ministero della SaluteDirezione Generale Ricerca Sanitaria e Biomedica e della Vigilanza sugli Enti

CODICE PROGETTO DESTINATARIO ISTITUZIONALE AREA Classificazione 1 Liv. SCORE. NOTE

BANDO 2010 RICERCA FINALIZZATA E GIOVANI RICERCATORI ‐ GRADUATORIA PROGETTI COLLABORAZIONE RICERCATORE ITALIANO ALL'ESTERO

Finanz.Richiesto

GR‐2010‐2317594

NEW GENETIC LESIONS CHARACTERIZING HIGH RISK CHRONIC LYMPHOCYTIC LEUKEMIA: CLINICAL AND FUNCTIONAL IMPLICATIONS

Piemonte BIO Oncology 2 ‐ Translational Clinical

4,5 € 600.000

RF‐2010‐2319316

High‐density EEG as a tool for localizing the epileptogenic zone in extratemporal refractory focal epilepsy: a validation study by means of Stereo‐EEG and post‐surgical outcome evaluation

Lombardia CLI Brain Disorders and Clinical Neuroscience

5 € 393.000

RF‐2010‐2310438

PROTECTIVE AND DANGEROUS IMMUNE RESPONSES DURING HIV‐1 INFECTION

OSPEDALE BAMBINO GESU'

CLI AIDS and Related Research 5 € 515.000

RF‐2010‐2318372

Novel surface and intracellular targets for tailored nanotechnology‐based drug delivery in colorectal cancer

SDN BIO Oncology 1 ‐ Basic Translational

5,5 € 530.000

RF‐2010‐2306232

Identification and functional validation of microRNA biomarkers in lung cancer

ISTITUTO TUMORI MILANO

BIO Oncology 2 ‐ Translational Clinical

6 € 396.000

RF‐2010‐2307403

Congenital anomalies of the kidney and urinary tract (CAKUT): definition of genetic and structural backgrounds based on high through‐put innovative approaches.

GASLINI BIO Digestive, Kidney and Urological Systems

6 € 355.000

RF‐2010‐2305199

Autophagy in the immune response against Mycobacterium tuberculosis: identification of novel rapamycin‐regulated host targets to improve BCG vaccine immunogenicity.

Istituto Superiore di Sanita' BIO Infectious Diseases and Microbiology

6 € 500.000

GR‐2010‐2318367

Biomarkers and functional imaging guided treatment decision making in recurrent prostate cancer.

Toscana CLI Oncology 2 ‐ Translational Clinical

6 € 470.000

Pagina 1 di 35



Finanz.Richiesto

RF‐2010‐2316198

PATHWAYS OF COAGULATION AND PLATELET ACTIVATION IN FLOWING BLOOD: NEW PERSPECTIVES IN THE MANAGEMENT OF ANTITHROMBOTIC THERAPY

C.R.O. AVIANO BIO Vascular and Hematology 6,25 € 525.000

GR‐2010‐2311329

Dissection of the immune response to human cytomegalovirus glycoprotein complexes: perspective for the development of a candidate subunit vaccine

SAN MATTEO BIO Immunology 6,33 € 445.000

RF‐2010‐2305605

Mechanisms of aggregation and toxicity of tau protein in Alzheimer's disease

IRCCS AOU San Martino‐IST (Genova)

BIO Molecular, Cellular, and Developmental Neuroscience

6,5 € 520.000

RF‐2010‐2316010

P2X7 receptor/MMP9 pathway in thrombosis and atherosclerotic plaque destabilization: exploring the possibility to modulate carotid plaque progression

SAN RAFFAELE MONTE TABOR

BIO Vascular and Hematology 6,5 € 548.800

RF‐2010‐2319059

Preparatory, response‐related, outcome‐evaluation and predictive components of attentional orienting in right brain damage: clues for diagnosis and rehabilitation

SANTA LUCIA CLI Biobehavioral and Behavioral Processes

6,5 € 400.000

RF‐2010‐2309704

Targeting drug resistance in Ovarian Cancer C.R.O. AVIANO BIO Oncology 2 ‐ Translational Clinical

6,5 € 540.000

GR‐2010‐2315414

mTOR‐dependent oscillatory metabolic switch controlling self‐immune tolerance

SANTA LUCIA BIO Immunology 6,75 € 570.000

RF‐2010‐2309790

Pemphigus vulgaris as a paradigm of autoantibody‐mediated organ‐specific autoimmune disorder: pathophysiology and novel tools for diagnosis and therapy

ISTITUTO DERMOPATICO DELL'IMMACOLATA

BIO Musculoskeletal, Oral and Skin Sciences

7 € 480.000

RF‐2010‐2305526

TArgeted Multistage vector (MSV) for the DIagnosis and treatment of Solid tumors

Veneto BIO Bioengineering Sciences and Technologies

7 € 478.000

GR‐2010‐2318448

Towards intervertebral disc regeneration: mesenchymal stem/stromal cells with a novel bioactive hydrogel based approach.

MAGGIORE BIO Musculoskeletal, Oral and Skin Sciences

7 € 550.000

Pagina 2 di 35



Finanz.Richiesto

RF‐2010‐2308270

Interleukin‐27 in the control of pediatric acute leukemia cell growth in NOD/SCID/Il2rg‐/‐ mice with human immune system

GASLINI BIO Immunology 7 € 520.000

RF‐2010‐2316197

HPV INFECTION AND DISEASE IN IMMUNOSUPRESSED MALES AND FEMALES:

PREVALENCE ANDVIRO‐IMMUNOLOGICAL DETERMINANTS OF ORGAN DAMAGE


BIO Immunology 7 € 315.000

RF‐2010‐2313497

Early detection and treatment of recurrent, chemotherapy‐resistant ovarian cancer stem cells by CPE peptide complexed superparamagnetic iron oxide nanoparticles (CPE‐SPIONs)



7 € 570.000

RF‐2010‐2315888

Dissecting the role of plasmacytoid dendritic cells in the progression of cutaneous melanoma

Lombardia BIO Oncology 1 ‐ Basic Translational

7 € 560.000

RF‐2010‐2317597

Identification of common biological pathways in Rett patients mutated in MECP2, CDKL5 and FOXG1.

Toscana BIO Molecular, Cellular, and Developmental Neuroscience

7 € 470.000

RF‐2010‐2318512

Role of influenza virus infection in the etiopathogenesis of diabetes

Istituto Zooprofilattico Sperimentale delle Venezie

BIO Infectious Diseases and Microbiology

7 € 470.000

RF‐2010‐2312580

The ECM molecule MULTIMEIN2 as a potential therapeutic tool to hamper tumor angiogenesis and tumor growth.

C.R.O. AVIANO BIO Oncology 1 ‐ Basic Translational

7 € 350.000

RF‐2010‐2306205

Noncoding RNAs and cancer IRCCS AOU San Martino‐IST (Genova)

BIO Oncology 1 ‐ Basic Translational

7 € 311.300

RF‐2010‐2305957

Enhancement of models for identification of patients with potential benefit from chronic care case/disease management programs.

Emilia‐Romagna CLI Healthcare Delivery and Methodologies

7 € 200.000

RF‐2010‐2310869

Overcoming the postmitotic state of terminally differentiated cells in favor of regenerative medicine

Istituto Superiore di Sanita' BIO Musculoskeletal, Oral and Skin Sciences

7 € 390.000

Pagina 3 di 35



Finanz.Richiesto

RF‐2010‐2318827

Microvescicles (MVs) in human Hepatocellular carcinoma (HCC): Potential for diagnostic and therapeutic applications.

Abruzzo BIO Oncology 1 ‐ Basic Translational

7 € 385.000

RF‐2010‐2321176

NOVEL APPROACH FOR BONE REGENERATION AND REPAIR USING SULFUR DONOR‐BASED THERAPY

RIZZOLI BIO Musculoskeletal, Oral and Skin Sciences

7,5 € 565.000

GR‐2010‐2311017

MacroH2A1 in the pathogenesis of metabolic syndrome‐associated hepatocellular carcinoma

CASA SOLLIEVO SOFFERENZA


7,5 € 379.555

GR‐2010‐2319582

Involvement of microRNAs in triple negative breast cancer: from biology to possible therapeutic applications.



7,5 € 363.200

GR‐2010‐2316264

Deregulation of molecular cross‐talk between NRF2/KEAP1 and BCL2 pathways in Non Small Cell Lung Cancer (NSCLC) and Small Cell lung Cancer (SCLC): implications for patients treatment.



7,5 € 350.000

RF‐2010‐2301677

Nanotechnology for the multiplex diagnosis of infectious diseases


7,5 € 560.000

RF‐2010‐2310716

Role of Th22 lymphocytes in the expression and persistence of psoriatic phenotype: identification of molecular pathways for innovative biologic therapy


BIO Immunology 7,5 € 470.000

RF‐2010‐2298992

Modulation of FoxO1 antioxidant function to prevent aging related disorders:diabetes and atherosclerosis

Abruzzo BIO Biology of Development and Aging

7,5 € 350.000

RF‐2010‐2318830

Role of the immunological impairment in progression of from MGUS to Multiple Myeloma

Sicilia BIO Oncology 1 ‐ Basic Translational

7,5 € 460.000

RF‐2010‐2318092

Molecular mechanisms underlying metabotropic glutamate (mGlu) receptor dysfunction in Fragile X syndrome

OASI MARIA S.S. BIO Molecular, Cellular, and Developmental Neuroscience

7,5 € 530.000

RF‐2010‐2318170

Cognitive, physiological and imaging correlates of visual hallucinations in Lewy body dementia: a multimodality functional study

S.CAMILLO CLI Brain Disorders and Clinical Neuroscience

7,5 € 280.000

Pagina 4 di 35



Finanz.Richiesto

RF‐2010‐2313390

Amniotic Fluid Stem Cells (AFSCs): molecular markers of osteogenic differentiation and pre‐clinical studies of orthopedic and odontoiatric diseases.

Abruzzo BIO Biology of Development and Aging

7,5 € 509.858

RF‐2010‐2319485

Nanotechnology‐based approach for induction of immune tolerance

Lazio BIO Bioengineering Sciences and Technologies

7,5 € 395.000

RF‐2010‐2318880

Prevention and Treatment of Hardware Infection Through Titanium Surface Modifications and Improved Wound Healing Through Nanoparticle Delivery Mechanisms.

MAUGERI BIO Bioengineering Sciences and Technologies

8 € 600.000

GR‐2010‐2318370

New nanotechnology and biomedical approaches to improve postoperative pain treatment reducing risks related to opioids

SAN MATTEO CLI Surgical Sciences, Biomedical Imaging, and Bioengineering

8 € 580.000

GR‐2010‐2320784

Development and preclinical assessment of an innovative endovascular device to occlude prosthetic paravalvular leakage

Veneto BIO Bioengineering Sciences and Technologies

8 € 540.000

GR‐2010‐2311677

High Throughput analysis of cancer cells for therapy evaluation by microfluidic platforms integrating plasmonic nanodevices

Calabria BIO Bioengineering Sciences and Technologies

8 € 600.000

RF‐2010‐2302437

RELEVANCE OF TMEM16A PROTEIN (ANOCTAMIN 1) IN THE PATHOPHYSIOLOGY OF CYSTIC FIBROSIS AND GASTROINTESTINAL MOTILITY DISORDERS

GASLINI BIO Cell Biology 8 € 600.000

RF‐2010‐2312243

Role of relaxin in bone metastasis Veneto BIO Oncology 1 ‐ Basic Translational

8 € 300.000

RF‐2010‐2317059

Identification and validation of miRNAs as novel biomarkers and therapeutic targets in diffuse malignant peritoneal mesothelioma



8 € 500.000

RF‐2010‐2309234

Characterization and functions of ROR{gamma}t+ IL22‐producing innate lymphoid cells in autoimmune and neoplastic human diseases

Sicilia BIO Immunology 8 € 390.000

Pagina 5 di 35



Finanz.Richiesto

RF‐2010‐2321104

Optoelectronic retinal prosthesis: the astrocyte approach to visual restoration.

Toscana BIO Emerging Technologies and Training in Neurosciences

8,25 € 440.000

RF‐2010‐2308133

Exploiting cellular transcription factors of the Interferon Regulatory Factors family in novel therapeutic approaches to HIV‐1 infection and reactivation from latency

Istituto Superiore di Sanita' BIO AIDS and Related Research 8,25 € 546.700

RF‐2010‐2309867

Targeting myeloid cells with novel nanotechnology‐based platforms to control metastatic disease

Veneto BIO Oncology 1 ‐ Basic Translational

8,5 € 596.000

GR‐2010‐2311890

Identification of miRNAs involved in the regulation of ALK expression in neuroblastoma



8,5 € 200.200

GR‐2010‐2319335

Empowering the brain. Induction of Hebbian‐like plasticity in cortico‐cortical neural networks with transcranial magnetic stimulation (TMS): investigations of functional connectivity in healthy subjects and clinical trials in stroke patients

Lazio BIO Brain Disorders and Clinical Neuroscience

8,5 € 520.000

GR‐2010‐2310981

Congenital Myopathies: genetic screening starting from a new diagnostic algorithm


CLI Musculoskeletal, Oral and Skin Sciences

8,5 € 550.000

RF‐2010‐2319081

Hypertension in high school students: Genetic and Environmental Factors

Toscana CLI Population Sciences and Epidemiology

8,5 € 600.000

RF‐2010‐2314954

Post‐partum depression:chronobiology , sleep‐related risk factors and light therapy

Emilia‐Romagna CLI Risk, Prevention and Health Behavior

8,5 € 0

RF‐2010‐2316490

Membrane remodeling and its role in malaria parasite infection and pathogenesis


8,5 € 260.700

RF‐2010‐2318970

ROLE OF REGULATORY T‐CELLS IN THE PATHOGENESIS AND THERAPY OF PRIMARY MYELOFIBROSIS

SAN MATTEO BIO Oncology 2 ‐ Translational Clinical

8,5 € 240.000

RF‐2010‐2312524

EVALUATION OF HUMAN ADIPOSE TISSUE‐DERIVED STROMAL CELLS FOR THE TREATMENT OF DIABETIC CARDIOVASCULAR COMPLICATIONS

SAN RAFFAELE PISANA BIO Endocrinology, Metabolism, Nutrition and Reproductive Sciences

8,5 € 580.000

Pagina 6 di 35



Finanz.Richiesto

GR‐2010‐2315762

Progressive Neurodegeneration in Primary Immunodeficiencies (PIDs): characterization, genetic predisposition, pathogenesis and identification of predictive biomarkers for diagnosis and follow‐up

FATEBENEFRATELLI BIO Immunology 8,5 € 405.020

RF‐2010‐2304935

Hypoxia in neuroblastoma tumors: from the biology to the identification of novel predictors of outcome

GASLINI BIO Oncology 1 ‐ Basic Translational

8,5 € 318.600

RF‐2010‐2309251

Role of Ezh2 in DNA damage response REGINA ELENA BIO Oncology 1 ‐ Basic Translational

8,5 € 600.000

RF‐2010‐2302590

Development of new peptide‐mimetic compounds and small organic molecules targeting the ErbB3/p85 interaction to improve ErbB2‐overexpressing metastatic breast cancers therapy

REGINA ELENA BIO Oncology 1 ‐ Basic Translational

8,5 € 300.000

RF‐2010‐2320561

Regulation of cancer stem cell symmetric divisions by myc I.E.O. BIO Oncology 1 ‐ Basic Translational

8,5 € 600.000

GR‐2010‐2307889

The role of macrophages in Primary Biliary Cirrhosis: novel targets for immune intervention

HUMANITAS BIO Immunology 8,75 € 539.000

RF‐2010‐2316566

Search for new genes and new therapies for Neonatal Diabetes Mellitus (NDM) and Hyperinsulinism and Hypoglycemia (HH).


CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences

8,75 € 300.000

GR‐2010‐2320696

Novel multi‐scale approach to 3d cancer models for the discovery of new therapeutic strategies for bone metastases

GALEAZZI BIO Oncology 1 ‐ Basic Translational

9 € 600.000

GR‐2010‐2319462

Nanometer‐size Gold Clusters Bioconjugates for Efficient Drug Delivery

C.R.O. AVIANO BIO Oncology 2 ‐ Translational Clinical

9 € 600.000

GR‐2010‐2319005

Dual ErbB‐3 and PI3K/AKT pathway inhibition as a novel approach to targeting cancer

Abruzzo BIO Oncology 2 ‐ Translational Clinical

9 € 350.000

GR‐2010‐2317750

Targeting neuroprotective endogenous neural stem cells in stroke

SANTA LUCIA CLI Brain Disorders and Clinical Neuroscience

9 € 407.000

Pagina 7 di 35



Finanz.Richiesto

RF‐2010‐2317957

Biochemical markers of brain damage following epileptic seizures in children and correlation with cognitive outcome and quantitative imaging data

Toscana CLI Brain Disorders and Clinical Neuroscience

9 € 265.000

RF‐2010‐2306483

RAPAMYCIN PLUS DPPIV INHIBITOR IN IMPROVING BETA CELL FUNCTION IN LONG‐STANDING TYPE 1 DIABETES: PROSPECTIVE RANDOMIZED TRIAL


BIO Endocrinology, Metabolism, Nutrition and Reproductive Sciences

9 € 550.000

RF‐2010‐2302555

IDENTIFICATION AND VALIDATION OF NEW THERAPEUTIC TARGETS FOR MULTIPLE MYELOMA PATIENTS

Emilia‐Romagna BIO Oncology 1 ‐ Basic Translational

9 € 287.777

RF‐2010‐2298966

Pre‐clinical assessment of innovative treatments against malignancies based on microRNAs



9 € 400.500

RF‐2010‐2321646

The impact of local sleep on awake human behavior Toscana BIO Integrative, Functional, and Cognitive Neuroscience

9 € 580.000

RF‐2010‐2302355

Innovation, education and treatment of drug abuse with dual diagnosis (INNUENDO)

Abruzzo CLI Risk, Prevention and Health Behavior

9,25 € 300.000

RF‐2010‐2320094

Gene identification in rare genetic disorders affecting lysosomal degradation pathways in skeletal muscle.

CARLO BESTA BIO Musculoskeletal, Oral and Skin Sciences

9,25 € 480.800

GR‐2010‐2313864

Role of hypoxia‐induced miR‐210 in tissue response to peripheral ischemia



GR‐2010‐2320147

Extracellular iron as a key signal in muscle necrosis and regeneration



RF‐2010‐2316726

Role of HIV‐1 infection on colorectal carcinoma onset and progression: development of novel therapeutic strategies

Istituto Superiore di Sanita' BIO AIDS and Related Research 9,25 € 533.500

RF‐2010‐2312196

Effects of testosterone supplementation on erythropoiesis: potential therapeutic implications in the anemia of older patients

Emilia‐Romagna CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences

9,5 € 157.500

Pagina 8 di 35



Finanz.Richiesto

RF‐2010‐2302573

EVALUATION OF THE SENSITIVITY AND SPECIFICITY OF DIFFERENT MEMORY TESTS FOR ALZHEIMER S DISEASE


CLI Brain Disorders and Clinical Neuroscience

9,5 € 600.000

GR‐2010‐2318314

Autoimmunity to PDGF receptor and DNA instability: a novel pathogenic mechanism with implications for new diagnostic and therapeutic tools in fibrotic diseases

Marche BIO Immunology 9,5 € 595.000

GR‐2010‐2319057

Robotic Therapy for balance recovery and evaluation in pediatrics


BIO Integrative, Functional, and Cognitive Neuroscience

9,5 € 330.000

RF‐2010‐2317381

New molecular pathways involved in coronary and carotid atherosclerosis



RF‐2010‐2319378

Quantitative assessment of spasticity: physiopathology and clinical application

SANTA LUCIA CLI Biobehavioral and Behavioral Processes

9,5 € 454.000

RF‐2010‐2315253

Role of squamous cell differentiation regulators in lung cancer.

SDN BIO Musculoskeletal, Oral and Skin Sciences

9,5 € 360.000

RF‐2010‐2308905

Reactive oxygen species (ROS) and phosphoinositide 3‐kinase (PI3K) signalling in breast cancer

Abruzzo BIO Oncology 1 ‐ Basic Translational

9,5 € 290.451

RF‐2010‐2303925

Assessing the immunomodulatory effect of probiotics in the Experimental Model of Myasthenia Gravis

CARLO BESTA BIO Brain Disorders and Clinical Neuroscience

9,5 € 495.300

RF‐2010‐2311107

ROLE OF THE DNAM‐1/PVR PATHWAY IN THE PATHOGENESIS OF HIV‐1 INFECTION


BIO AIDS and Related Research 9,5 € 252.500

GR‐2010‐2311772

The role of T cells in postmenopausal bone loss: focus on autoreactive T cells in peripheral blood of patients affected by severe form of osteoporosis.

Piemonte BIO Immunology 9,5 € 205.000

RF‐2010‐2308348

THE GASTRIC SUBMUCOSAL SPACE(GSMS) AS A SITE FOR ISLET ALLOTRANSPLANTATION WITH THE USE OF ALEMTUZUMAB

Sicilia BIO Endocrinology, Metabolism, Nutrition and Reproductive Sciences

10 € 600.000

GR‐2010‐2319063

The role of eNOS in neoplastic progression induced by chronic stress.

PASCALE BIO Oncology 1 ‐ Basic Translational

10 € 600.000

Pagina 9 di 35



Finanz.Richiesto

GR‐2010‐2306686

Effects of cognitive and aerobic training on cognitive performances and the resting state brain activity in aging individuals

Abruzzo BIO Biobehavioral and Behavioral Processes

10 € 594.000

GR‐2010‐2302599

Targeting Histone Acetylation as a Approach to Cancer Therapy

REGINA ELENA BIO Oncology 2 ‐ Translational Clinical

10 € 500.000

GR‐2010‐2318215

Assessment of the diagnostic value of novel salivary and lachrymal biomarkers for the early non‐invasive diagnosis of primary Sjögren s syndrome

Toscana BIO Musculoskeletal, Oral and Skin Sciences

10 € 405.000

RF‐2010‐2309791

SURVEILLANCE OF MULTI‐DRUG RESISTANT (MDR) MICRO‐ORGANISM AND FUNGI COLONIZATION AND INFECTIONS ACQUIRED IN A NOSOCOMIAL SETTING, WITH PARTICULAR REFERENCE TO SURGICAL INFECTIONS IN CANCER PATIENTS AND EMERGENCY SURGERY PATIENTS.

Sicilia CLI Risk, Prevention and Health Behavior

10 € 150.000

RF‐2010‐2312990

Role of HIF factors in leukemogenesis and evaluation of the effectiveness of their targeting as anti‐leukemia therapy



10 € 490.000

RF‐2010‐2316030

Translational Research Strategies for Treatment of Acute Neurodegenerative Disorders


10 € 566.500

RF‐2010‐2317527

A new approach to diagnosis in muscular diseases CARLO BESTA BIO Genes, Genomes and Genetics

10 € 532.550

RF‐2010‐2306978

Lysophosphatidic acid (LPA) as a lipid modulator of tumor/stroma cross‐talk during HCC tumor progression

ONCOLOGICO DI BARI BIO Oncology 1 ‐ Basic Translational

10 € 500.000

RF‐2010‐2318457

Susceptibility to heat in cohorts of births, children and elderly: a multi‐centric study to identify short‐term effects of heat, effect modifiers and to study long term exposure effects over a ten year period

Lazio BIO Population Sciences and Epidemiology

10 € 400.000

RF‐2010‐2319391

Comprehensive analysis for identification of prognostic and predictive epigenetic signature in Renal Cell Carcinoma


10 € 450.000

Pagina 10 di 35



Finanz.Richiesto

RF‐2010‐2321072

Neurophysiological and functional connectivity markers of fluctuating cognition and attention disorders in Dementia with Lewy Bodies and Parkinson s Disease with Dementia

NEUROLESI BIO Brain Disorders and Clinical Neuroscience

10,25 € 400.000

RF‐2010‐2314622

DOPAMINERGIC MODULATION OF TONIC GABAA INHBITION: PATHOPHYSIOLOGICAL AND THERAPEUTIC IMPLICATIONS FOR ABSENCE SEIZURES

NEUROMED BIO Brain Disorders and Clinical Neuroscience

10,5 € 300.000

GR‐2010‐2318791

Study of the role of epigenetics in the regulation of microRNA expression in heart failure to identify novel therapeutic targets

HUMANITAS BIO Cardiovascular and Respiratory Sciences

10,5 € 572.000

GR‐2010‐2321515

Modulation of HIF by new synthetic PHD2 inhibitors for a new and effective treatment of ischemic heart failure

SAN DONATO BIO Cardiovascular and Respiratory Sciences

10,5 € 500.000

GR‐2010‐2311146

Long term safety and efficacy of thalidomide in IBD. BURLO GAROFALO CLI Digestive, Kidney and Urological Systems

10,5 € 425.000

RF‐2010‐2319721

Whole‐exome approach to identify the gene responsible for a novel condition associating severe mental retardation with skeletal dysplasia (SEMD‐Mental Retardation)

ARCISPEDALE BIO Genes, Genomes and Genetics

10,5 € 184.100

RF‐2010‐2311325

ROLE OF TGFbeta AND HER‐2 PATHWAYS IN THE DEVELOPMENT OF EMT, ENDOCRINE RESISTANCE AND BREAST CANCER PROGRESSION

Sicilia BIO Oncology 2 ‐ Translational Clinical

10,5 € 585.000

RF‐2010‐2307091

ECHOCARDIOGRAPHIC EPICARDIAL FAT THICKNESS AS NEW PREDICTIVE MARKER OF CARDIOVASCULAR EVENTS AND CARDIAC REMODELLING

SAN DONATO CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences

10,5 € 150.000

RF‐2010‐2314888

PRE‐CLINICAL EVALUATIONS OF CELL THERAPY FOR OSTEOARTHRITIS TREATMENT


10,5 € 520.000

RF‐2010‐2306728

Molecular and metabolic signature of Gleason grading in prostate cancer

Emilia‐Romagna BIO Oncology 1 ‐ Basic Translational

10,5 € 450.000

Pagina 11 di 35



Finanz.Richiesto

RF‐2010‐2310964

A toxicological redox assay as a new tool for the discovery of susceptibility biomarkers in Parkinson s disease

MONDINO BIO Brain Disorders and Clinical Neuroscience

10,75 € 492.800

RF‐2010‐2315335

Genomic and proteomic profiling in Traumatic Brain Injury patients.

Sicilia BIO Brain Disorders and Clinical Neuroscience

11 € 397.000

GR‐2010‐2319243

Collaboratory and remote mentoring: a strategy to optimize pancreatic islet isolation .

Sicilia BIO Endocrinology, Metabolism, Nutrition and Reproductive Sciences

11 € 462.000

GR‐2010‐2319431

Chimeric antigen receptor‐redirected T cells targeting CD19 for therapy of high‐risk/relapsed childhood acute lymphoblastic leukemia



11 € 600.000

GR‐2010‐2321629

Fragile X Protein in breast cancer progression CASA SOLLIEVO SOFFERENZA


11 € 500.000

GR‐2010‐2309252

MicroRNA as predictive biomarkers in Hepatoblastoma pediatric tumour

Istituto Superiore di Sanita' BIO Oncology 1 ‐ Basic Translational

11 € 550.000

GR‐2010‐2318041

Enteric glial cells: at the crossroads of obesity, gastrointestinal neurodysfunction and gut bacterial endotoxins

MEDEA BIO Digestive, Kidney and Urological Systems

11 € 460.000

GR‐2010‐2318297

Exploring the role of Epstein‐Barr virus infection and innate immune signalling pathways in the pathogenesis of myasthenia gravis


11 € 567.248

RF‐2010‐2318911

CLINICAL AND GENETIC CHARACTERIZATION OF EARLY COMPLICATIONS IN JUVENILE OBESITY


CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences

11 € 592.000

RF‐2010‐2315795

Genetics of cardiovascular disease in patients with type 2 diabetes. An integrated approach, including epidemiology, gene expression profiles and cell biology functional studies


BIO Genes, Genomes and Genetics

11 € 600.000

RF‐2010‐2311016

Hexanucleotide repeat expansion in c9orf72 as a bridge between amyotrophic lateral sclerosis and other neurodegenerative diseases.

AUXOLOGICO BIO Brain Disorders and Clinical Neuroscience

11 € 593.000

Pagina 12 di 35



Finanz.Richiesto

RF‐2010‐2309665

A novel in‐vivo diagnostic test for Creutzfeldt‐Jakob disease (CJD) patients by nasal brushing

Istituto Superiore di Sanita' BIO Brain Disorders and Clinical Neuroscience

11 € 270.000

GR‐2010‐2318650

Group I metabotropic glutamate receptors and regulation of synaptic plasticity in a mouse model of Angelman syndrome


11 € 300.000

RF‐2010‐2309134

New insigths in the treatment of necrotizing enterocolitis: Modulation of the cholinergic anti‐inflammatory pathway with the use of melanocortins in an experimental neonatal model.

Sicilia BIO Surgical Sciences, Biomedical Imaging, and Bioengineering

11 € 300.000

RF‐2010‐2317851

Unveiling the microbial signature of Coeliac Disease SDN BIO Infectious Diseases and Microbiology

11 € 550.000

RF‐2010‐2299665

Novel therapeutic approaches to counteract neuronal loss and cognitive decline in an animal model of AD

Abruzzo BIO Brain Disorders and Clinical Neuroscience

11 € 592.072

RF‐2010‐2308550

ADVANCED THERAPY IN THE TREATMENT OF SKIN LOSS: HUMAN ALLODERMIS WITH PLATELET GEL AND MINIMALLY MANIPULATED MESENCHIMAL STEM CELLS.

Toscana CLI Surgical Sciences, Biomedical Imaging, and Bioengineering

11 € 372.000

RF‐2010‐2304785

Correction of Beta‐Haemoglobinopathies after in situ gene transfer by homologous recombination

Liguria BIO Genes, Genomes and Genetics

11 € 400.000

RF‐2010‐2307118

Molecular genetic variants and circulating levels of natriuretic peptides: assessment of their predictive role for cardiovascular acute events and cardiovascular diseases in a general Italian population

NEUROMED CLI Cardiovascular and Respiratory Sciences

11 € 300.000

RF‐2010‐2320967

The early phases of diabetic retinopathy: possible role of Pigmented Epithelium Derived Factor in contrasting neuroglial dysfunction

Istituto Superiore di Sanita' BIO Cell Biology 11 € 380.000

GR‐2010‐2311620

DO INHIBITORY NETWORKS SUSTAIN SEIZURE GENESIS IN FOCAL EPILEPSY?


11,25 € 300.500

Pagina 13 di 35



Finanz.Richiesto

RF‐2010‐2312459

Cellular and molecular determinants of mitral valve prolapse

MONZINO BIO Cardiovascular and Respiratory Sciences

11,5 € 405.556

RF‐2010‐2312101

Toxins produced by intestinal bacteria and predisposing genetic variations: a dangerous link for colorectal cancer development?


11,5 € 397.000

GR‐2010‐2313839

Acid Retinoic‐Producing Dendritic Cells as New Therapy for Type 1 Diabetes

Sicilia BIO Immunology 11,5 € 180.000

GR‐2010‐2311169

Autoimmunity in Diabetes: a Holistic Hypothesis of the Diabetes Syndrome

SAN DONATO BIO Immunology 11,5 € 325.000

GR‐2010‐2315189

Circuitry rearrangement and clinical outcome of high technological platform based‐ restorative therapy in an ovine model of stroke: definition of microenvironment interactions and epigenetic modification contribution


11,5 € 572.300

GR‐2010‐2312195

Mitochondria involvement in synaptic dysfunction during early stage of Alzheimer's disease


11,5 € 407.000

RF‐2010‐2318415

Mechanism of hypertrophy in genetically determined Hypertrophic Cardiomyopathy (HCM)

Lombardia BIO Cardiovascular and Respiratory Sciences

11,5 € 600.000

RF‐2010‐2311018

Identification of humoral and cellular biomarkers for cerebro and coronary acute vascular events

NEUROMED CLI Vascular and Hematology 11,5 € 300.000

RF‐2010‐2311956

The role of mineralocorticoid receptor (MR) overactivation in obesity:effects of MR blockade in

human and animal models of overfeeding.

SAN RAFFAELE PISANA BIO Endocrinology, Metabolism, Nutrition and Reproductive Sciences

11,5 € 580.000

RF‐2010‐2311565

ANALYSIS OF PHERIPHERAL BLOOD DENDRITIC CELLS IN ALZHEIMER S DISEASE

SANTA LUCIA BIO Brain Disorders and Clinical Neuroscience

11,5 € 400.000

RF‐2010‐2310625

Production and optimization of cartilage and bone spherules for repairing large bone losses and osteoarthritis.

Istituto Superiore di Sanita' BIO Musculoskeletal, Oral and Skin Sciences

11,5 € 500.000

Pagina 14 di 35



Finanz.Richiesto

RF‐2010‐2320054

Disability related chronic conditions in older adults: an innovative approach to estimate the disease burden and the adherence to evidence‐based pharmacological treatments using linked clinical and administrative data.

Lazio CLI Healthcare Delivery and Methodologies

11,5 € 300.000

RF‐2010‐2319473

Corticostriatal alterations in dopamine‐graft transplanted parkinsonian rats: implications for L‐DOPA therapy


11,5 € 430.000

RF‐2010‐2317931

Prediction of targeted therapies for hepatocellular carcinoma through molecular profiling of tumorous and cirrhotic tissue

Emilia‐Romagna BIO Oncology 2 ‐ Translational Clinical

11,5 € 540.000

GR‐2010‐2312436

The role of B cells in Graft‐versus‐Host Disease after allogeneic hemopoietic cell transplantation

Provincia autonoma Bolzano


GR‐2010‐2308317

Identification of new genetic variations involved in Bipolar I disorder via all exome sequencing of families with high genetic vulnerability from a founder Sardinian population

FATEBENEFRATELLI BIO Genes, Genomes and Genetics

12 € 599.000

RF‐2010‐2319788

Controlled Ex Vivo Expansion of Human Mesenchymal Stem Cells Methodologies: A First Step Toward Clinically Relevant Bone Regeneration

RIZZOLI BIO Cell Biology 12 € 328.000

RF‐2010‐2300967

IN PURSUIT OF NOVEL THERAPEUTIC STRATEGIES FOR NON‐ALCOHOLIC FATTY LIVER DISEASE: UNDERSTANDING THE ROLE OF LITAF PROTEIN.


BIO Digestive, Kidney and Urological Systems

12 € 488.000

RF‐2010‐2307645

Exploiting endoplasmic reticulum aminopeptidases modulation for innovative strategies of anticancer immunotherapy



RF‐2010‐2319774

UNRAVELING MECHANISMS UNDERLYING THE RECOVERY OF WALKING ABILITY IN STROKE SURVIVORS

Emilia‐Romagna CLI Brain Disorders and Clinical Neuroscience

12 € 600.000

Pagina 15 di 35



Finanz.Richiesto

GR‐2010‐2315085

Prospective, Randomized, Multi‐Center Trial of Lateral Trendelenburg versus Semi‐Recumbent Body Position in Mechanically Ventilated Patients For The Prevention of Ventilator‐Associated Pneumonia

MAGGIORE CLI Infectious Diseases and Microbiology

12 € 600.000

GR‐2010‐2317866

New specific calcium inhibitor BZ194 as potential modulator of Myasthenia Gravis


12 € 430.000

GR‐2010‐2321987

Scaffold‐assisted mesenchymal stem cells therapy for cartilage tissue engineering

GALEAZZI BIO Musculoskeletal, Oral and Skin Sciences

12 € 600.000

RF‐2010‐2319842

Associations between ambulatory blood pressure monitoring profiles, cognitive decline, and diastolic dysfunction in the very elderly population: a multicentre study to identify novel, population‐specific, management algorithms.

AUXOLOGICO CLI Cardiovascular and Respiratory Sciences

12 € 400.000

GR‐2010‐2321727

Sodium channel Nav1.1: the most relevant epilepsy gene. Pathomechanisms and development of novel therapeutic strategies.

Lombardia BIO Molecular, Cellular, and Developmental Neuroscience

12 € 197.000

RF‐2010‐2309532

Role of purinergic receptor P2X7R in ischemic tissue damage and collateral vessels development

SAN RAFFAELE PISANA BIO Cardiovascular and Respiratory Sciences

12 € 600.000

RF‐2010‐2298967

Studies on the functional role and regulation of a restricted signature of microRNAs in acute myeloid leukemia


12 € 300.000

RF‐2010‐2320500

Validation of a health technology for calculating fractionated doses for pediatric drugs

Piemonte CLI Healthcare Delivery and Methodologies

12 € 240.000

RF‐2010‐2309615

IDENTIFICATION OF NEW DISEASE GENES IN MITOCHONDRIAL COMPLEX I DEFICIENCY


BIO Brain Disorders and Clinical Neuroscience

12 € 578.000

RF‐2010‐2312752

Adipocyte‐derived leptin as a new tool to manipulate immune response in Tuberculosis


12 € 600.000

Pagina 16 di 35



Finanz.Richiesto

RF‐2010‐2309741

Hereditary spastic paraplegia: generation of cellular and animal models to dissect the complex interplay of the pathways involved combined with novel tools for disease diagnosis

MEDEA BIO Brain Disorders and Clinical Neuroscience

12 € 600.000

RF‐2010‐2304907

Turning expression into advantage: a new tool for regulatory T cell therapy

BURLO GAROFALO BIO Immunology 12 € 560.000

RF‐2010‐2315045

Myocardial regeneration and functional recovery of the infarcted heart:role of pericardial fluids

SAN RAFFAELE PISANA BIO Cardiovascular and Respiratory Sciences

12 € 300.000

RF‐2010‐2304930

Development of vaccines to control salmonellosis using attenuated strains with altered metal uptake capability

Istituto Superiore di Sanita' BIO Veterinary 12 € 480.000

RF‐2010‐2320697

Functional validation of candidate oncogenes in pancreatic cancer



12 € 450.000

GR‐2010‐2313877

A defect in TLR7 gene expression impaires innate and adaptive immunity in Multiple Sclerosis patients: intracellular mechanisms as therapeutic targets

Istituto Superiore di Sanita' BIO Immunology 12,25 € 350.000

RF‐2010‐2311277

ULTRA‐HIGH FIELD(7T)MAGNETIC RESONANCE SYSTEM: NEUROMUSCOLAR APPLICATIONS

STELLA MARIS CLI Brain Disorders and Clinical Neuroscience

12,5 € 178.500

RF‐2010‐2303770

Role of Human Papilloma Virus in Head and Neck Cancer.

I.E.O. BIO Infectious Diseases and Microbiology

12,5 € 360.000

RF‐2010‐2312240

Molecular characterization of the epithelial‐mesenchimal transition process underlying idiopathic pulmonary fibrosis and lung cancer.

SAN MATTEO BIO Cardiovascular and Respiratory Sciences

12,5 € 500.000

RF‐2010‐2315861

Role of multiple HPV infections in the development of cervical diseases.

BURLO GAROFALO CLI Infectious Diseases and Microbiology

12,5 € 175.000

RF‐2010‐2314813

MEDITERRANEAN DIET, PHYTO‐ESTROGENS AND RECURRENCE OF COLORECTAL ADENOMAS. A MULTICENTER RANDOMIZED CONTROLLED TRIAL .

DE BELLIS BIO Oncology 2 ‐ Translational Clinical

12,5 € 400.000

Pagina 17 di 35



Finanz.Richiesto

RF‐2010‐2313125

The role of microbial agents in prostate cancer pathogenesis


12,5 € 463.290

RF‐2010‐2321885

FK‐506 Pharmacogenetics/Pharmacogenomics and new approaches in FK‐506 therapeutic drug monitoring in pediatric and adult liver transplantation

Piemonte BIO Immunology 12,5 € 300.000

GR‐2010‐2321227

Unravelling the susceptibility to develop rotator cuff tears and its role onto surgical outcome



12,5 € 290.000

GR‐2010‐2317163

Modularity for sensory motor control: implications of muscles synergies in motor recovery after stroke.

S.CAMILLO CLI Biobehavioral and Behavioral Processes

12,5 € 294.000

GR‐2010‐2311331

INTERMED Self Assessment Study (IMSAS) ‐ Self‐assessed clinical evaluation of bio‐psycho‐social complexity

Emilia‐Romagna CLI Healthcare Delivery and Methodologies

12,5 € 110.000

GR‐2010‐2305115

Pathway association and genetic interaction analysis for genome wide association study of cerebrovascular ischemic diseases in the Italian population

CARLO BESTA CLI Genes, Genomes and Genetics

12,5 € 571.100

RF‐2010‐2312613

Phenotypic characterization and genomic sequencing in schizophrenia

SAN RAFFAELE PISANA BIO Genes, Genomes and Genetics

12,5 € 593.000

GR‐2010‐2321373

Investigation of B cell function and diversity in patients with SCID‐X1 following HSCT or gene therapy

Toscana BIO Immunology 12,75 € 195.000

RF‐2010‐2314589

Modulation of pharmacogenomic and pharmacodynamic biomarkers of glucose metabolism by metronomic chemotherapy in cancer and endothelial cells

Toscana BIO Oncology 2 ‐ Translational Clinical

13 € 240.000

GR‐2010‐2321033

Pulmonary Valve Implantation using Self‐expanding Tissue Valve without Cardiopulmonary Bypass: a

Controlled Randomised Clinical Trial

MAGGIORE CLI Surgical Sciences, Biomedical Imaging, and Bioengineering

13 € 460.000

GR‐2010‐2321979

Daily at‐home follow‐up of Parkinson s Disease patients motor performance through robotic and portable devices

SAN RAFFAELE PISANA BIO Brain Disorders and Clinical Neuroscience

13 € 600.000

Pagina 18 di 35



Finanz.Richiesto

GR‐2010‐2320268

Indoleamine 2,3‐Dioxygenase and Peripheral Tolerance to Exogenous Factor VIII:A Multi‐Centre Study

Umbria BIO Vascular and Hematology 13 € 284.000

GR‐2010‐2310943

NAD‐dependent signaling as a target in cerebrovascular disease: a preclinical assessment in mouse disease models


BIO Brain Disorders and Clinical Neuroscience

13 € 585.000

RF‐2010‐2305545

TLR2 at the crossroads between infections and Multiple Sclerosis in human and experimental pathology

Lazio BIO Immunology 13 € 400.000

RF‐2010‐2315369

Effect of dopamine treatment on neurocognitive functioning in Parkinson s disease: a fMRI study


13 € 400.000

RF‐2010‐2309338

Analysis of pattern recognition receptor activation in cognitively impaired subjects


13 € 354.440

RF‐2010‐2316216

Molecular bases of phenotypic heterogeneity of Alzheimer's disease: diagnostic and therapeutic implications


13 € 540.000

RF‐2010‐2320177

From personality to molecular mechanisms through neurocognitive phenotypes: a translational study of liability to compulsive drug‐seeking


13 € 413.600

GR‐2010‐2311289

A novel in vivo model to study molecular determinants in lymphopoietic disorders


13 € 538.800

RF‐2010‐2311213

The KidsInPlaces Initiative: an international partnership for the study of societal resilience and early child development

Emilia‐Romagna CLI Population Sciences and Epidemiology

13,25 € 220.000

GR‐2010‐2318337

In vivo imaging of microglia signature: from mouse models to brain injured patients

MAGGIORE BIO Molecular, Cellular, and Developmental Neuroscience

13,25 € 529.000

GR‐2010‐2315805

EARLY EVENTS IN THE INDIRECT PATHWAY IN ANIMAL MODELS OF PARKINSON S DISEASE.


13,25 € 290.000

Pagina 19 di 35



Finanz.Richiesto

GR‐2010‐2312633

Evaluation of chemotherapy induced liver damage in patients with colorectal liver metastasis using of non invasive tools

REGINA ELENA CLI Digestive, Kidney and Urological Systems

13,5 € 250.000

RF‐2010‐2319227

Early risk indicators and prevention of dementia following stroke.

S.CAMILLO CLI Brain Disorders and Clinical Neuroscience

13,5 € 600.000

GR‐2010‐2319078

Integration of high throughput and analytical data to discover biomarkers of cell‐products quality and therapy efficacy in dendritic‐cells‐based cancer immunotherapy studies

Istituto Superiore di Sanita' BIO Oncology 2 ‐ Translational Clinical

13,5 € 350.000

RF‐2010‐2317978

Glucocorticoid receptor polymorphisms and Corticosteroid‐Binding Globulin polymorphisms may modulate the clinical effects of immunosuppressive therapy with corticosteroids in determining the risk of developing diabetes after kidney transplantation.

Marche CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences

13,5 € 250.000

RF‐2010‐2317080

Clinical impact of accurate patient specific three‐dimensional treatment planning in molecular radiotherapy

ARCISPEDALE BIO Oncology 2 ‐ Translational Clinical

13,5 € 600.000

RF‐2010‐2312849

Unlocking tumor immune recognition through self HLA‐E molecules

REGINA ELENA BIO Immunology 13,5 € 300.000

GR‐2010‐2319264

Integration of expression profiles and genetic mapping data to identify risk variants in IgA nephropathy

Puglia BIO Digestive, Kidney and Urological Systems

13,5 € 450.000

RF‐2010‐2319175

DEVELOPMENT OF AN INTEGRATED BIOSTATISTICS AND BIOINFORMATICS FRAMEWORK FOR CLINICAL TRANSLATION AND EVALUATION OF NEW BIOMARKER TECHNOLOGIES



13,5 € 212.000

RF‐2010‐2310982

The neurobiology of social behaviour: physiological and pathological processes in mice and humans

Istituto Superiore di Sanita' BIO Biobehavioral and Behavioral Processes

13,75 € 526.000

Pagina 20 di 35



Finanz.Richiesto

RF‐2010‐2303796

PREGNANCIES IN WOMEN WITH PREVIOUS ADVERSE OBSTETRIC EVENTS AND PREGNANCY‐RELATED VENOUS THROMBOEMBOLISM : NEW DIAGNOSTIC TOOLS AND IMPROVEMENT OF THERAPEUTHIC STRATEGIES



14 € 300.000

GR‐2010‐2321960

Identification of new genes responsible for Albinism phenotype

Lombardia BIO Genes, Genomes and Genetics

14 € 220.000

GR‐2010‐2308290

Understanding and treating impairment in automatic movements execution in Parkinson's disease


CLI Integrative, Functional, and Cognitive Neuroscience

14 € 150.000

GR‐2010‐2306549

Molecular determinants of tumour resistance to radio/chemotherapies

Veneto BIO Oncology 2 ‐ Translational Clinical

14 € 450.000

GR‐2010‐2315899

Vaccine platform for oncogenic viruses. PASCALE BIO Immunology 14 € 587.500

GR‐2010‐2313075

Synaptic alteration of mGluR signaling underlying SHANK3 mutations in intellectual disability and their rescue by pharmacological therapies

CARLO BESTA BIO Molecular, Cellular, and Developmental Neuroscience

14 € 360.000

RF‐2010‐2312951

Tuberculosis control among immigrants in Italy: a cost‐effectiveness assessment.

Piemonte CLI Infectious Diseases and Microbiology

14 € 360.000

RF‐2010‐2320796

Mechanisms of altered DNA methylation in sporadic and hereditary colorectal cancer

REGINA ELENA BIO Genes, Genomes and Genetics

14 € 600.000

RF‐2010‐2320335

Identification of slow proliferating cancer cells with stem‐like features


14 € 570.000

RF‐2010‐2314055

Innovative therapeutic approaches against CD49d‐driven microenvironmental interactions in chronic lymphocytic leukemia


14 € 600.000

RF‐2010‐2317730

LCAT MODULATION TO TREAT ATHEROSCLEROTIC CARDIOVASCULAR DISEASE

Lombardia BIO Vascular and Hematology 14 € 350.000

Pagina 21 di 35



Finanz.Richiesto

RF‐2010‐2314049

Hormonal implications in the mesothelioma pathogenesis.


14 € 596.500

RF‐2010‐2311234

Using hyperbaric‐hyperoxigenated‐transportable machine to preserve liver to be transplanted.A new preservation method evaluated throught an animal model transplantation study.

Emilia‐Romagna BIO Surgical Sciences, Biomedical Imaging, and Bioengineering

14 € 600.000

RF‐2010‐2320258

THERapeutically relevant STEM cells for THALassemia (THERSTEMTHAL)

Emilia‐Romagna BIO Genes, Genomes and Genetics

14 € 600.000

GR‐2010‐2303803

Fighting Alzheimer: new prospectives and therapeutical strategies


14 € 644.800

RF‐2010‐2314240

Enpowering neuromodulation by individually tuned brain‐behavior frequency

Istituto Superiore di Sanita' BIO Emerging Technologies and Training in Neurosciences

14,25 € 230.000

RF‐2010‐2312471

Neurobiological bases of the Impulse Control Disorders: the role of the cerebellum.


14,5 € 230.000

GR‐2010‐2318381

Effects of Antidepressant Drugs on Autophagy pathway in neurons

MONDINO BIO Brain Disorders and Clinical Neuroscience

14,5 € 600.000

GR‐2010‐2314036

Oncolytic HSV vector strategy for the study of TRIM8 role in the pathogenesis of glioblastoma and therapy.



14,5 € 571.000

GR‐2010‐2314427

Autoantibodies specific to ATP synthase in the pathogenesis of Alzheimer disease

SAN RAFFAELE PISANA BIO Brain Disorders and Clinical Neuroscience

14,5 € 540.000

GR‐2010‐2315991

Tailoring electrical parameters of subthalamic nucleus stimulation to treat behavioural symptoms in Parkinson s disease

MAGGIORE CLI Brain Disorders and Clinical Neuroscience

14,5 € 408.800

RF‐2010‐2314571

Effect of Human C‐Peptide on the Prevention of Diabetic Retinopathy and Nephropathy in a Rat Model of Type 2 Diabetes



14,5 € 400.000

RF‐2010‐2315800

EARLY ENVIRONMENTAL RISK FACTORS AND THE RISK OF DEVELOPING ANOREXIA NERVOSA

FATEBENEFRATELLI CLI Brain Disorders and Clinical Neuroscience

14,5 € 350.000

Pagina 22 di 35



Finanz.Richiesto

RF‐2010‐2314660

Myocardial Toll‐like receptors in human myocarditis. SAN RAFFAELE PISANA CLI Cardiovascular and Respiratory Sciences

14,5 € 363.000

RF‐2010‐2312530

Wnt/b‐catenin signaling in melanoma: in vitro and in vivo investigations

SAN GALLICANO BIO Oncology 1 ‐ Basic Translational

14,5 € 520.000

RF‐2010‐2313681

Use of antisense oligonucleotides to PTPN22 gene variant conjugated to immuno‐liposomes as a novel therapeutic approach in type 1 diabetes and autoimmune polyendocrine syndrome type 3 variant


CLI Immunology 14,5 € 600.000

RF‐2010‐2307217

Wilson disease: methionine metabolism and epigenetic regulation of gene expression

Veneto BIO Genes, Genomes and Genetics

14,5 € 500.000

RF‐2010‐2315965

Host biomarkers in exhalate breath condensate and other accessible body fluids for clinical and incipient tuberculosis detection


BIO Infectious Diseases and Microbiology

14,5 € 600.000

RF‐2010‐2320384

Preclinical studies on TM9SF4, a novel potential biomarker associated with malignancy in patients with skin cancers


14,5 € 500.000

RF‐2010‐2312125

Role of Notch in regulation of mesenchymal cells from adipose tissue of heart failure patients: consequences for cell therapy

MAUGERI BIO Cardiovascular and Respiratory Sciences

14,5 € 400.000

RF‐2010‐2317428

DEVELOPMENT OF VALIDATED INSTRUMENTS TO ASSESS SPINAL CORD INJURY (SCI) SUBJECTS.


14,75 € 295.000

RF‐2010‐2318892

Mother‐delivered infant massage in preterm infants to promote neurodevelopment and bonding: effects on infant sleep and brain maturation

STELLA MARIS CLI Brain Disorders and Clinical Neuroscience

14,75 € 115.000

GR‐2010‐2309621

NEUROREHABILITATIVE PROGRAM FOR LIMB APRAXIA BY NEUROMODULATION OF LINGUISTIC VICARIOUS SKILLS

FATEBENEFRATELLI BIO Integrative, Functional, and Cognitive Neuroscience

14,75 € 580.000

Pagina 23 di 35



Finanz.Richiesto

RF‐2010‐2319562

Study of the interactions between noise and vibration exposure in view of the assessment of synergistic effect on the cochlea

Ist. Sup. per la Prevenzione e Sicurezza sul Lavoro

BIO Risk, Prevention and Health Behavior

14,75 € 585.000

GR‐2010‐2312697

Impaired VitaminD metabolism in Rheumatoid Arthritis. Implication for disease pathogenesis and treatment.

Piemonte CLI Musculoskeletal, Oral and Skin Sciences

15 € 300.000

GR‐2010‐2316050

Transcranial Direct Current Stimulation as treatment in depressive illness: mechanism of action and efficacy

MAGGIORE CLI Brain Disorders and Clinical Neuroscience

15 € 310.000

GR‐2010‐2308883

The role of internal models in locomotor schemas and neurorehabilitation of children with cerebral palsy


15 € 350.000

GR‐2010‐2318987

The VERY SHINING (Vessels, Endothelium and Risk in the next Years. Sodium Handling and INtake: INteractions with Genes) Study.

Veneto CLI Cardiovascular and Respiratory Sciences

15 € 400.000

GR‐2010‐2313156

Gaining new insights into the molecular mechanisms underlying the cholangiocarcinoma

REGINA ELENA BIO Genes, Genomes and Genetics

15 € 250.000

GR‐2010‐2316602

Role of FOXP3 in breast cancer metastatic process and possible therapeutic targeting



15 € 357.500

GR‐2010‐2309328

Novel strategies for tackling obesity epidemics by targeting the resting energy expenditure (EE)

AUXOLOGICO CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences

15 € 460.000

GR‐2010‐2312856

GENERATION OF PRION PROTEIN‐BASED COMPOUNDS AS NOVEL THERAPEUTIC STRATEGY FOR ALZHEIMER'S DISEASE

Lombardia BIO Brain Disorders and Clinical Neuroscience

15 € 595.000

GR‐2010‐2316389

LONGITUDINAL CHANGES IN MICROARCHITECTURE AND NEURONAL METABOLISM ASSOCIATED WITH PROPRIOCEPTIVE TRAINING TO AMELIORATE BALANCE IN MULTIPLE SCLEROSIS

REGINA ELENA CLI Emerging Technologies and Training in Neurosciences

15 € 415.000

RF‐2010‐2318768

Shaping the autoimmune response in the gut: the role of intestinal microbiota in immune regulation of Type 1 Diabetes



Pagina 24 di 35



Finanz.Richiesto

GR‐2010‐2318218

Diffusion Weighted Imaging (DWI) for the detection and monitoring of pulmonary inflammation: preliminary assessment and validation with molecular imaging.

Veneto BIO Surgical Sciences, Biomedical Imaging, and Bioengineering

15 € 300.000

GR‐2010‐2317973

Cerebrospinal fluid and serum biomarkers of brain damage in epilepsy

NEUROLESI CLI Brain Disorders and Clinical Neuroscience

15 € 370.500

RF‐2010‐2316350

Induced pluripotent stem cell (iPSC) technology in the study of human genetic diseases of the hematologic system: modelling and correcting the cellular and genetic defect

HUMANITAS BIO Immunology 15 € 600.000

GR‐2010‐2309479

Risk assessment and safety procedures for MRI examination on patients with deep brain stimulators

Istituto Superiore di Sanita' BIO Surgical Sciences, Biomedical Imaging, and Bioengineering

15 € 400.000

RF‐2010‐2314737

Multimodal optical imaging platform for video‐rate intraoperative near infrared fluorescence cardiac imaging.

Provincia autonoma Trento BIO Surgical Sciences, Biomedical Imaging, and Bioengineering

15 € 520.000

GR‐2010‐2319145

Identification of predictive biomarkers of pegIFN‐alpha‐induced depression and comprehension of the underlying mechanisms

FATEBENEFRATELLI BIO Brain Disorders and Clinical Neuroscience

15 € 400.000

RF‐2010‐2318954

Identification of new biomarkers in rhabdomyosarcoma: potential targets of novel therapeutic strategies.



15 € 600.000

RF‐2010‐2319109

OVERCOMING TARGETED TREATMENT RESISTANCE IN HUMAN CANCER: NOVEL STRATEGIES TO INHIBIT SURVIVAL AND ESCAPE SIGNALS AND TARGETED DELIVERY OF ANTI‐CANCER NANOPARTICLES

REGINA ELENA BIO Oncology 2 ‐ Translational Clinical

15 € 600.000

RF‐2010‐2314017

Exploitation of immunogenic tumor cell death for improved dendritic cell‐based cancer vaccines


15 € 550.000

RF‐2010‐2314997

Identification of a panel of enteric‐hepatic biomarkers in children with an elevated risk of cardiovascular disease and type 2 diabetes

Toscana CLI Cardiovascular and Respiratory Sciences

15 € 581.000

Pagina 25 di 35



Finanz.Richiesto

RF‐2010‐2317496

Plasma factors, integrins and modulators of podocyte shape. A new window on focal segmental glomerulosclerosis and its treatment

GASLINI BIO Digestive, Kidney and Urological Systems

15 € 208.440

RF‐2010‐2318760

The impact of the insulin/IGF‐I pathway in bladder cancer invasion and metastasis

Calabria BIO Oncology 1 ‐ Basic Translational

15 € 420.000

GR‐2010‐2299397

Development of new strategies to study alcoholism: evaluation of toxicity, tolerance and ethanol dependence mechanisms by molecular imaging, genetic and epigenetic analysis

Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise

BIO Molecular, Cellular, and Developmental Neuroscience

15 € 433.000

RF‐2010‐2319269

DIALECTICAL BEHAVIOR THERAPY (DBT) VS. HIGH‐QUALITY OUTPATIENT CARE FOR BORDERLINE PERSONALITY DISORDER. A PRAGMATIC RANDOMIZED TRIAL.

Emilia‐Romagna CLI Biobehavioral and Behavioral Processes

15 € 300.000

RF‐2010‐2311225

Improving the diagnostic homogeneity in schizophrenia using cognitive endophenotypes: an integrated genetic, neuroimaging and neurocognitive approach


15,25 € 600.000

RF‐2010‐2319204

Targeting mitochondria‐associated Heat Shock Proteins, autophagy and bioenergetics in human solid tumors

MAGGIORE BIO Oncology 2 ‐ Translational Clinical

15,5 € 380.000

GR‐2010‐2321042

Neural correlates of apathy and Executive Dysfunction in Parkinson s disease.

NEUROLESI BIO Brain Disorders and Clinical Neuroscience

15,5 € 420.000

GR‐2010‐2312269

Neural response to behavioral treatments in Focal Hand Dystonia

Veneto CLI Brain Disorders and Clinical Neuroscience

15,5 € 385.000

GR‐2010‐2319406

Neurophysiological indices of functional network integration in vegetative and minimally conscious patients and their relation to awareness and prognosis


15,5 € 490.000

GR‐2010‐2313440

Molecular tools for the diagnosis and treatment of early placentation defects and related pregnancy pathologies

BURLO GAROFALO BIO Endocrinology, Metabolism, Nutrition and Reproductive Sciences

15,5 € 225.000

Pagina 26 di 35



Finanz.Richiesto

RF‐2010‐2315471

Muscle Catabolism Fuels Anabolic Tumor Growth: Translational and Therapeutic Implications

GASLINI BIO Oncology 1 ‐ Basic Translational

15,5 € 258.000

RF‐2010‐2306180

Development of Training Optimization Techniques for Robot‐assisted Neurorehabilitation.

MAUGERI BIO Brain Disorders and Clinical Neuroscience

15,5 € 450.000

RF‐2010‐2312206

MicroRNAs as potential diagnostic and therapeutic tools for Multiple Osteochondromas disease


15,5 € 468.000

RF‐2010‐2305056

Cancer and Heart study: Cancer from Radiological medical imaging in cardiovascular patients


15,5 € 301.000

RF‐2010‐2317543

Air pollution, Epigenomic Arterial Signatures, and Post Heart‐Surgery Risk of Cardiovascular Events

MAGGIORE BIO Genes, Genomes and Genetics

15,5 € 570.000

RF‐2010‐2320087

Hormonal changes and impaired spermatogenesis in young males with different levels of spinal cord injury: A longitudinal study

MAUGERI CLI Endocrinology, Metabolism, Nutrition and Reproductive Sciences

15,5 € 150.000

RF‐2010‐2309199

Brain‐heart axis impairment in stroke patients: integration of neuroimaging data with cardiovascular variability signals.

Istituto Superiore di Sanita' BIO Brain Disorders and Clinical Neuroscience

15,5 € 395.000

RF‐2010‐2319131

Global and gene‐specific DNA methylation in maternal‐infant pairs, environmental exposures, and subsequent respiratory and neurobehavioral phenotypes in childhood

Lazio BIO Genes, Genomes and Genetics

15,5 € 600.000

GR‐2010‐2319470

ELBA.PSDEcological Language Behaviour Assessment For Post Stroke Dementia


15,75 € 200.000

RF‐2010‐2311912

Lower limb robotic exoskeleton for children with motor impairment



15,75 € 600.000

RF‐2010‐2321986

Oxidative stress induced DNA damage response and autophagy in skeletal muscle cells: mechanisms and implication for muscle dystrophy

SANTA LUCIA BIO Biology of Development and Aging

15,75 € 600.000

GR‐2010‐2300170

Impact of influenza vaccination in HIV‐1 multi‐treated elderly patients

Istituto Superiore di Sanita' BIO AIDS and Related Research 16 € 435.000

Pagina 27 di 35



Finanz.Richiesto

RF‐2010‐2321005

Study of SP‐A polymorphisms as a predictor of over‐all lung transplant outcome.

SAN MATTEO BIO Cardiovascular and Respiratory Sciences

16 € 300.000

RF‐2010‐2315568

Clinical and molecular genetic spectrum of Coenzyme Q10 deficiencies: identifications of new phenotypes and genetic variants. Implications for the pathogenesis and therapeutic approach.

NEUROLESI CLI Genes, Genomes and Genetics

16 € 338.000

RF‐2010‐2314830

The hMena alternative splicing program and host immune response in EMT and breast tumor progression


16 € 280.000

RF‐2010‐2315820

Innovative combinatorial therapeutic strategies to revert resistance to target therapy in NSCLC

PASCALE BIO Oncology 2 ‐ Translational Clinical

16 € 580.000

RF‐2010‐2317064

Biocompetent dendrons (BD) vs platelet‐rich plasma (PRP) finalized to induce angiogenesis and bone regeneration in osteonecrosis.

Marche BIO Musculoskeletal, Oral and Skin Sciences

16 € 480.000

RF‐2010‐2310905

Gene identification in muscle disorders disrupting cell‐extracellular matrix interactions

CARLO BESTA BIO Musculoskeletal, Oral and Skin Sciences

16 € 480.500

RF‐2010‐2319783

Preventing onset of psychosis in high risk youths: identification and treatment

MONDINO CLI Brain Disorders and Clinical Neuroscience

16 € 396.000

RF‐2010‐2318826

Autoimmunome‐driven immunotherapy of Alzheimer's Disease

Piemonte BIO Brain Disorders and Clinical Neuroscience

16,25 € 280.000

GR‐2010‐2319637

Structure, Function and New Insight Strategies for Prevention of Left Atrium Remodeling In Mouse Heart Failure

MONZINO BIO Cardiovascular and Respiratory Sciences

16,5 € 510.000

GR‐2010‐2304836

Role of Mcl‐1 protein in tumor angiogenesis and progression


16,5 € 400.000

GR‐2010‐2311275

Multimodality MR imaging (DTI, fMRI and quantitative relaxometry) for the evaluation of cerebral modifications induced by different rehabilitation protocols in children with cerebral palsy and traumatic brain injury.

MEDEA CLI Brain Disorders and Clinical Neuroscience

16,5 € 545.000

Pagina 28 di 35



Finanz.Richiesto

GR‐2010‐2312350

PHENOTYPE VARIABILITY IN PRNP E200K MUTATION CARRIERS: A CLINICAL, GENETIC AND PROTEOMIC STUDY

Istituto Superiore di Sanita' BIO Genes, Genomes and Genetics

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SiPIMIS (Single Portal with Intraperitoneal Magnetic Instruments Surgery): a brand new no scar surgical

approach for major abdominal intervention.

Lombardia BIO Surgical Sciences, Biomedical Imaging, and Bioengineering

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Assessment and management of risk factors for sleep disordered breathing and sleep bruxism in pediatric populations. The role of Orthodontics.

Emilia‐Romagna CLI Integrative, Functional, and Cognitive Neuroscience

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Engineering the microenvironment of implantable matrices to enhance the host response to tissue damages: a new regenerative medicine approach for wound healing


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Biotherapy of Colorectal Carcinoma by enhancing HLA‐class II expression and cooperation with CD16+ myeloid cells in the CRC microenvironment

Lazio BIO Oncology 2 ‐ Translational Clinical

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Biomarkers of adverse neuropsychological outcomes in pre‐term newborns: Structural/functional connectivity Magnetic Resonance Imaging (MRI), Electroencephalography (EEG) and genetics

Abruzzo CLI Brain Disorders and Clinical Neuroscience

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Linguistic competence screening for dementia in patients with ischemic stroke.


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Genetics and molecular biomarkers of Food Allergy Toscana BIO Genes, Genomes and Genetics

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Genomic and Proteomic Biomarkers in Patients with Subarachnoid Hemorrhage

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Multimodal MRI in the degenerative brain diseases SANTA LUCIA CLI Brain Disorders and Clinical Neuroscience

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Nutrient Signaling Pathways and Immune Response in the Sensitization of Neuroblastoma and Breast Cancer to Chemotherapy

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Bioengineering of TAVI Istituto Superiore di Sanita' BIO Cardiovascular and Respiratory Sciences

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Cancer stem cells as a model of carcinogenesis for head and neck squamous cell carcinoma: new technologies with potential to translate from the laboratory into the clinic.

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Recruitment, computer‐assisted electroencephalographic analysis and functional evaluation in Encephalopathy with Status Epilepticus during Sleep/Continuous Spike and Waves during Sleep.

MONDINO CLI Brain Disorders and Clinical Neuroscience

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Predicting recidivism of driving under the influence of alcohol and drug. A genetic, neuropsychological and evoked potential study.

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HUNT FOR NEW DISEASE GENES IN CONGENITAL MUSCULAR DYSTROPHY WITH HYPOGLYCOSYLATED ALPHA‐DYSTROGLYCAN

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Clinical and biological markers in unipolar vs bipolar depression

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HEREDITARY EARLY ONSET ATAXIAS: DIAGNOSTIC PROTOCOLS AND THERAPEUTIC STRATEGIES


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Mesenchymal stem cells and islet co‐transplantation in diabetic rats: natural chemistry and physical Energy to improve graft revascularization and function by human adipose derived stem cells

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Effects of ambulatory oxygen on breathlessness, mobility and quality of life in patients with idiopathic pulmonary fibrosis


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Genetic polymorphism and bisphosphonate‐related osteonecrosis of the jaws: a case control study

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Evaluation of effect of PARP inhibitors with or without irradiation in preclinical models of soft‐tissue sarcomas.

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Quantitative gait analysis in older adults with Alzheimer s disease and mild cognitive impairment: pathophysiological meaning and possible clinical applications


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Iron in cholangiocarcinoma: from understanding the role to possible development of novel treatments

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Studies on antibodies in single‐chain format against the HPV16 E6, E7 oncoproteins as a novel therapeutic approach for HPV‐associated lesions.


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Role of leukocyte telomere length and CD34+ hematopoietic precursor telomerase activity in the pathogenesis of cellular senescence in diabetic nephropathy

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Genetic and functional analysis of circulating microRNAs in multiple sclerosis: potential prognostic biomarkers of disease course?

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Use of saliva as biological matrix for non invasive screening of oral cancer ‐ ONCOSAL (ONCOlogical Diagnosis by SALiva)

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Role of type I IFN in dictating the immunogenicity of chemotherapy and in predicting the therapeutic efficacy of anticancer treatments


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