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Manlio PALUMBO

Settore Scientifico Disciplinare: CHIM/08 - Chimica farmaceutica Qualifica: Professore Ordinario Anzianità nel ruolo: 01/11/1990 Sede Universitaria: Università degli Studi di PADOVA Struttura di afferenza (dipartimento o altro): SCIENZE DEL FARMACO

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2017

Articolo in rivista Mologni L., Dalla Via M., Chilin A., Palumbo M., Marzaro G. (2017) Discovery of novel wtRET and V804MRET inhibitors: from hit to lead.CHEMMEDCHEM, ISSN: 1860-7187, DOI: 10.1002/cmdc.201700243

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2017

Articolo in rivista Scalabrin M., Quintieri L., Palumbo M., Riccardi Sirtori F., Gatto B. (2017) Virtual Cross-Linking of the Active Nemorubicin Metabolite PNU-159682 to Double-Stranded DNA. CHEMICAL RESEARCH IN TOXICOLOGY, vol. 30, p. 614-624, ISSN: 0893-228X, DOI: 10.1021/acs.chemrestox.6b00362

3

2017

Articolo in rivista Rigo R., Palumbo M., Sissi C. (2017) G-quadruplexes in human promoters: A challenge for therapeutic applications. BIOCHIMICA ET BIOPHYSICA ACTA, vol.1861(5 Pt B), p.1399-1413, ISSN: 0304-4165, DOI: 10.1016/j.bbagen.2016.12.024

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2017

Articolo in rivista Lago S., Tosoni E., Nadai M., Palumbo M., Richter S.N. (2017) The cellular protein nucleolin preferentially binds long-looped G-quadruplex nucleic acids. BIOCHIMICA ET BIOPHYSICA ACTA, vol.1861(5 Pt B), p.1371-1381, ISSN: 0304-4165, DOI: 10.1016/j.bbagen.2016.11.036

Posizione accademica

Pubblicazioni scientifiche

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2016

Articolo in rivista Rigo Riccardo, Bianco Sara, Musetti Caterina, Palumbo Manlio, Sissi Claudia (2016). Molec Basis for Differential Recognition of G-Quadruplex versus Double-Helix DNA by Bis-Phenan Metal Complexes. CHEMMEDCHEM, vol. 11, p. 1762-1769, ISSN: 1860-7179, doi: 10.1002/cmdc.201600129

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2016

Articolo in rivista Zorzan E., S. DA Ros, Musetti C., ZORRO SHAHIDIAN L., RAMOS COELHO N.F., Bonse F., Létard S., Gelain M.E, Palumbo M., Dubreuil P., Giantin M., Sissi C., Dacasto M. (2016). Screening of candidate G-quadruplex ligands for the human c-KIT promotorial region and th in multiple in-vitro models. ONCOTARGET, vol. 7, p. 21658-21675, ISSN: 1949-2553, doi: 10.18632/oncotarget.7808

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2015

Articolo in rivista Litta Pietro, Saccardi Carlo, Gizzo Salvatore, Conte Lorena, Ambrosi Giulia, Sissi Claudia, Manlio (2015). Inflammatory cytokine expression following the use of bipolar electrocoagulat ultracision harmonic scalpel and cold knife biopsy. MOLECULAR MEDICINE REPORTS, vo 2985-90-2990, ISSN: 1791-2997, doi: 10.3892/mmr.2015.3677

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2015

Articolo in rivista Nadai Matteo, Cimino-Reale Graziella, Sattin Giovanna, Doria Filippo, Butovskaya Elena, Z Nadia, Freccero Mauro, Palumbo Manlio, Richter Sara N., Folini Marco (2015). Assessment promoter G-quadruplex binding and modulation by a naphthalene diimide derivative in tumo INTERNATIONAL JOURNAL OF ONCOLOGY, vol. 46, p. 369-380, ISSN: 1019-6439, doi: 10.3892/ijo.2014.2723

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2015

Articolo in rivista Parrino Barbara, Carbone Anna, Spanò Virginia, Montalbano Alessandra, Giallombardo Da Barraja Paola, Attanzio Alessandro, Tesoriere Luisa, Sissi Claudia, Palumbo Manlio, Cirrinc Girolamo, Diana Patrizia (2015). Aza-isoindolo and isoindolo-azaquinoxaline derivatives wit antiproliferative activity. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 94, p. 3 ISSN: 0223-5234, doi: 10.1016/j.ejmech.2015.03.009

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2015

Articolo in rivista Parrino Barbara, Carbone Anna, Ciancimino Cristina, Spanò Virginia, Montalbano Alessand Barraja Paola, Cirrincione Girolamo, Diana Patrizia, Sissi Claudia, Palumbo Manlio, Pinato Pennati Marzia, Beretta Giovanni, Folini Marco, Matyus Peter, Balogh Balázs, Zaffaroni Nad (2015). Water-soluble isoindolo[2,1-a]quinoxalin-6-imines: In vitro antiproliferative activity an molecular mechanism(s) of action. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v 149-162, ISSN: 0223-5234, doi: 10.1016/j.ejmech.2015.03.005

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2015

Articolo in rivista Morellato N, Musetti C., Palumbo M., Dolmella A., Bolzati C., Sissi C. (2015). Biologically rel Cu2+ complexes with a tridentate phenanthroline analogue: structural properties and DNA d INORGANICA CHIMICA ACTA, vol. 434, p. 127-134, ISSN: 0020-1693, doi: 10.1016/j.ica.2015.04.037

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2014

Articolo in rivista S. Da Ros, E. Zorzan, M. Giantin, L. Zorro Shahidian, M. Palumbo, M. Dacasto, C. Sissi (20 Sequencing and G-quadruplex folding of the canine proto-oncogene KIT promoter region: m be used as a model for human disease?. PLOS ONE, vol. 9, ISSN: 1932-6203, doi: 10.1371/journal.pone.0103876

13

2014

Articolo in rivista C. Sissi, M. Palumbo (2014). Telomeric G-quadruplex architecture and interactions with pot drugs . CURRENT PHARMACEUTICAL DESIGN, vol. 20, p. 6489-6509, ISSN: 1381-6128

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2014

Articolo in rivista Giuseppe Zagotto, Alessandra Gianoncelli, Claudia Sissi, Cristina Marzano, Valentina Gand Riccardo Pasquale, Giovanni Capranico, Giovanni Ribaudo, Manlio Palumbo (2014). Novel Ametantrone-Amsacrine Related Hybrids as Topoisomerase II? Poisons and Cytotoxic Age ARCHIV DER PHARMAZIE, vol. 347, p. 728-737, ISSN: 0365-6233, doi: 10.1002/ardp.201

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2013

Articolo in rivista Matteo Nadai, Giovanna Sattin, Giorgio Palù, Manlio Palumbo, Sara N. Richter (2013). Clerocidin-mediated DNA footprinting discriminates among different G-quadruplex conforma detects tetraplex folding in a duplex environment. BIOCHIMICA ET BIOPHYSICA ACTA-GE SUBJECTS, vol. 1830, p. 4660-4668, ISSN: 0304-4165, doi: 10.1016/j.bbagen.2013.05.039

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2013

Articolo in rivista Rosalba Perrone, Matteo Nadai, Ilaria Frasson, Jerrod A. Poe, Elena Butovskaya, Thomas Smithgall, Manlio Palumbo, Giorgio Palù, Sara N. Richter (2013). A Dynamic G-Quadruplex Regulates the HIV-1 Long Terminal Repeat Promoter. JOURNAL OF MEDICINAL CHEMIS 56, p. 6521-6530, ISSN: 0022-2623, doi: 10.1021/jm400914r

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2013

Articolo in rivista Filippo Doria, Matteo Nadai, Marco Folini, Matteo Scalabrin, Luca Germani, Giovanna Sattin Mella, Manlio Palumbo, Nadia Zaffaroni, Daniele Fabris, Mauro Freccero, Sara N. Richter (2 Targeting Loop Adenines in G-Quadruplex by a Selective Oxirane. CHEMISTRY-A EUROP JOURNAL, vol. 19, p. 78-81, ISSN: 0947-6539, doi: 10.1002/chem.201203097

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2013 Articolo in rivista G. Sattin, A. Artese, M. Nadai, G. Costa, L. Parrotta, S. Alcaro, M. Palumbo, S.N. Richter (2 Conformation and Stability of Intramolecular Telomeric G-Quadruplexes: Sequence Effects i Loops. PLOS ONE, vol. 8, ISSN: 1932-6203, doi: 10.1371/journal.pone.0084113

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2013

Articolo in rivista R. Perrone, M. Nadai, J.A. Poe, I. Frasson, M. Palumbo, G. Palù, T.E. Smithgall, S.N. Richt Formation of a Unique Cluster of G-Quadruplex Structures in the HIV-1 nef Coding Region: Implications for Antiviral Activity. PLOS ONE, vol. 8, ISSN: 1932-6203, doi: 10.1371/journal.pone.0073121

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2013 Articolo in rivista Sara Bianco, Caterina Musetti, A. Paul Krapcho, Manlio Palumbo, Claudia Sissi (2013). Ni2 Cu2+ complexes of a phenanthroline-based ligand bind to G-quadruplexes at non-overlappi CHEMICAL COMMUNICATIONS, vol. 49, p. 8057-8059, ISSN: 1359-7345, doi: 10.1039/c3

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2013 Articolo in rivista C. Musetti, A. P. Krapcho, M. Palumbo, C. Sissi (2013). Effect of G-quadruplex polymorphis recognition of telomeric DNA by a metal complex. PLOS ONE, vol. 8, ISSN: 1932-6203, doi: 10.1371/journal.pone.0058529

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2013 Articolo in rivista C. Sissi, B. Cheng, V. Lombardo, Y.C. Tse-Dinh, M. Palumbo (2013). Metal ion and inter-do interactions as functional networks in E. coli topoisomerase I. GENE, vol. 524, p. 253-260, I 0378-1119, doi: 10.1016/j.gene.2013.04.008

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2012

Articolo in rivista Orlotti NI, Cimino-Reale G, Borghini E, Pennati M, Sissi C, Perrone F, Palumbo M, Daidone Folini M, Zaffaroni N (2012). Autophagy acts as a safeguard mechanism against G-quadrup ligand-mediated DNA damage.. AUTOPHAGY, vol. 8, p. 1185-1196, ISSN: 1554-8627, doi: 10.4161/auto.20519

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2012 Articolo in rivista R. K. Nanjunda, C. L. Musetti, A. Kumar, M. A. Ismail, S. Wang, C. SISSI, M. Palumbo, D. W. D. Wilson (2012). Heterocyclic Dications as a New Class of Telomeric G-Quadruplex Tar Agents. CURRENT PHARMACEUTICAL DESIGN, vol. 18, p. 1934-1947, ISSN: 1381-6128

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2012 Articolo in rivista MARSON G, M. PALUMBO, SISSI C (2012). Folding versus charge: understanding selectiv recognition by the thrombin aptamers. CURRENT PHARMACEUTICAL DESIGN, vol. 18, p. 2027-2035, ISSN: 1381-6128

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2012 Articolo in rivista Matteo Nadai, Giorgio Palù, Manlio Palumbo, Sara N. Richter (2012). Differential Targeting Unpaired Bases within Duplex DNA by the Natural Compound Clerocidin: A Valuable Tool t DNA Secondary Structure. PLOS ONE, vol. 7, ISSN: 1932-6203, doi: 10.1371/journal.pone.

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2012 Monografia o trattato scientifico Yu. M. Yevdokimov, S. G. Skuridin, V. I. Salyanov, V. A. Bykov, M. Palumbo (2012). Structu Nanotechnology: Liquid-Crystalline Approach . p. 1-32, Transworld Research Network, ISB 9788178955896

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2011 Articolo in rivista G. Marson, M. Palumbo, C. SISSI (2011). Structural and functional characterization of thro binding aptamer minor loop. INTERNATIONAL REVIEW OF BIOPHYSICAL CHEMISTRY, 102-104, ISSN: 2038-0321

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2011

Articolo in rivista ZAGOTTO G, RICCI A, VAZQUEZ E, SANDOLI A, BENEDETTI S, M. PALUMBO, SISSI C Tuning G-quadruplex vs. double stranded DNA recognition in regioisomeric lysyl-peptidyl-anthraquinone conjugates. BIOCONJUGATE CHEMISTRY, vol. 22, p. 2126-2 ISSN: 1043-1802, doi: 10.1021/bc200389w

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2011 Articolo in rivista DI ANTONIO M, PERCIVALLE C, LA ROSA A, VERGA D, DORIA F, MELLA M, M. PALUM FRECCERO M (2011). Quinone Methide Generation via Photoinduced Electron Transfer. J OF ORGANIC CHEMISTRY, vol. 76, p. 3096-3106, ISSN: 0022-3263

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2011

Articolo in rivista NADAI M, DORIA F, DI ANTONIO M, SATTIN G, GERMANI L, PERCIVALLE C, M. PALUM RICHTER S N, FRECCERO M (2011). Naphthalene diimide scaffolds with dual reversible a covalent interaction properties towards G-quadruplex. BIOCHIMIE, vol. 93, p. 1328-1340, IS 0300-9084, doi: 10.1016/j.biochi.2011.06.015

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2011 Articolo in rivista SISSI C, GATTO B, M. PALUMBO (2011). The evolving world of protein-G-quadruplex reco medicinal chemist's perspective. BIOCHIMIE, vol. 93, p. 1219-1230, ISSN: 0300-9084, doi: 10.1016/j.biochi.2011.04.018

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33 2011

Articolo in rivista BACILIERI M, NAGGI A, CEOL M, SCHLEICHER E, TOSETTO E, COMOLI M, TORRI G, M M. PALUMBO, GAMBARO G (2011). Inhibitory effects of glycosaminoglycans on basal and stimulated transforming growth factor-beta 1 expression in mesangial cells: biochemical and structural considerations. GLYCOBIOLOGY, vol. 21, p. 1029-1037, ISSN: 0959-6658, doi: 10.1093/glycob/cwr038

34 2011 Articolo in rivista C. Musetti, S. Bianco, A. P. Krapcho, M. Palumbo, C. SISSI (2011). Differential binding mod phenanthroline-base metal complex to a DNA or RNA telomeric sequence. INTERNATIONA REVIEW OF BIOPHYSICAL CHEMISTRY, vol. 2, p. 156-158, ISSN: 2038-0321

35 2010

Articolo in rivista LOREGIAN A, MERCORELLI B, MURATORE G, SINIGALIA E, PAGNI S, MASSARI S, GR G, GATTO B, PALUMBO M, TABARRINI O, CECCHETTI V, PALU' G. (2010). The 6-Aminoquinolone WC5 Inhibits Human Cytomegalovirus Replication at an Early Stage by I with the Transactivating Activity of Viral Immediate-Early 2 Protein. ANTIMICROBIAL AGEN CHEMOTHERAPY, vol. 54, p. 1930-1940, ISSN: 0066-4804, doi: 10.1128/AAC.01730-09

36 2010

Articolo in rivista VERGA D, NADAI M, DORIA F, PERCIVALLE C, DI ANTONIO M, PALUMBO M., RICHTER FRECCERO M (2010). Photogeneration and Reactivity of p-Naphthoquinone Methides as P Selective DNA Alkylating Agents.. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v p. 14625-14637, ISSN: 0002-7863, doi: 10.1021/ja1063857

37 2010

Articolo in rivista TABARRINI O, MASSARI S, DAELEMANS D, MESCHINI F, MANFRONI G, BOTTEGA L, G PALUMBO M., PANNECOUQUE C, CECCHETTI V (2010). Studies on Anti-HIV Transcripti Inhibitor Quinolones: Identification of Potent N-1-Vinyl Derivatives. CHEMMEDCHEM, vol. 5 1880-1892, ISSN: 1860-7179, doi: 10.1002/cmdc.201000267

38 2010

Articolo in rivista SISSI C., E. VAZQUEZ, A. CHEMELLO, L. A. MITCHENALL, A. MAXWELL, M. PALUMBO Mapping simocyclinone D8 interaction to DNA gyrase: evidence for a new binding site on G ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 54, p. 213-220, ISSN: 0066-4804, 10.1128/AAC.00972-09

39 2010

Articolo in rivista BIANCO S, MUSETTI C, WALDECK A, SPARAPANI S, SEITZ J.D, KRAPCHO A.P, PALUM SISSI C (2010). Bis-phenanthroline derivatives as suitable scaffolds for effective G-quadrup recognition. DALTON TRANSACTIONS, vol. 39, p. 5833-5841, ISSN: 1477-9226, doi: 10.1039/c0dt00038h

40 2010 Articolo in rivista RICHTER SN, FRASSON I, PALUMBO M, SISSI C, PALU' G. (2010). Simocyclinone D8 tur against Gram-negative bacteria in a clinical setting. BIOORGANIC & MEDICINAL CHEMIST LETTERS, vol. 20, p. 1202-1204, ISSN: 0960-894X, doi: 10.1016/j.bmcl.2009.11.135

41 2010

Articolo in rivista FOLINI M, PIVETTA C, ZAGOTTO G, DE MARCO C, PALUMBO M., ZAFFARONI N, SISSI (2010). Remarkable interference with telomeric function by a G-quadruplex-selective bisantr regioisomer. BIOCHEMICAL PHARMACOLOGY, vol. 79, p. 1781-1790, ISSN: 0006-2952, d 10.1016/j.bcp.2010.02.018

42 2010 Articolo in rivista SISSI C, PALUMBO M. (2010). In front of and behind the replication fork: bacterial type IIA topoisomerases. CELLULAR AND MOLECULAR LIFE SCIENCES, vol. 67, p. 2001-2024, I 1420-682X, doi: 10.1007/s00018-010-0299-5

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2010

Articolo in rivista GIANONCELLI A, BASILI S, SCALABRIN M, SOSIC A, MORO S, ZAGOTTO G, PALUMB GRESH N, GATTO B (2010). Rational Design, Synthesis, and DNA Binding Properties of N Sequence-Selective Peptidyl Congeners of Ametantrone. CHEMMEDCHEM, vol. 5, p. 1080 ISSN: 1860-7179, doi: 10.1002/cmdc.201000106

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2010

Brevetto Palumbo Manlio, Gatto Barbara, Pescador Rodolfo, Porta Roberto, Ferro Laura Iris (2010). DNA-based aptamers for human cathepsin G . 7,838,506, Gentium S.p.A

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2009 Articolo in rivista MUSETTI C, LUCATELLO L, BIANCO S, KRAPCHO A P, CADAMURO S A, PALUMBO M. (2009). Metal ion-mediated assembly of effective phenanthroline-based G-quadruplex ligan DALTON TRANSACTIONS, vol. 21, p. 3657-3660, ISSN: 1477-9226, doi: 10.1039/b904630

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2009

Articolo in rivista M. DI ANTONIO, F. DORIA, S. N. RICHTER, C. BERTIPAGLIA, M. MELLA, SISSI C., M. P M. FRECCERO (2009). Quinone methides tethered to naphthalene diimides as selective G-quadruplex alkylating agents. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol 13132-13141, ISSN: 0002-7863, doi: 10.1021/ja904876q

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2009 Articolo in rivista RICHTER S, MENEGAZZO I, NADAI M, MORO S, PALUMBO M. (2009). Reactivity of Cler towards adenine: implications for base modulated DNA damage. ORGANIC & BIOMOLECU CHEMISTRY, vol. 7, p. 976-985, ISSN: 1477-0520, doi: 10.1039/b819049f

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2009

Articolo in rivista RICHTER SN, NADAI M, PALUMBO M, PALU' G. (2009). Topoisomerase I involvement in schedule-dependent interaction between 5-fluoro-uracil and irinotecan in the treatment of co cancer.. CANCER CHEMOTHERAPY AND PHARMACOLOGY, vol. 64, p. 199-201, ISSN: 0344-5704, doi: 10.1007/s00280-009-0971-3

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2009

Articolo in rivista MANFRONI G, GATTO B, TABARRINI O, SABATINI S, CECCHETTI V, GIARETTA G, PA DEL VECCHIO C, CALISTRI A., PALUMBO M, FRAVOLINI A (2009). Synthesis and biologi evaluation of 2-phenylquinolones targeted at Tat/TAR recognition.. BIOORGANIC & MEDIC CHEMISTRY LETTERS, vol. 19(3), p. 714-717, ISSN: 0960-894X, doi: 10.1016/j.bmcl.2008

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2009 Articolo in rivista SISSI C, PALUMBO M. (2009). Effects of Magnesium and related divalent metal ions in topoisomerase structure and function. NUCLEIC ACIDS RESEARCH, vol. 37, p. 702-711, I 0305-1048, doi: 10.1093/nar/gkp024

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2009 Articolo in rivista GATTO B, PALUMBO M., SISSI C (2009). Nucleic acid aptamers based on the G-quadrupl structure: therapeutic and diagnostic potential. CURRENT MEDICINAL CHEMISTRY, vol. 1 1248-1265, ISSN: 0929-8673

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2009

Articolo in rivista GATTO B, TABARRINI O, MASSARI S, GIARETTA G, SABATINI S, DEL VECCHIO C, PA FRAVOLINI A, PALUMBO M, CECCHETTI V (2009). 2-phenylquinolones as inhibitors of th Tat/TAR interaction.. CHEMMEDCHEM, vol. 4, p. 935-938, ISSN: 1860-7179, doi: 10.1002/cmdc.200800437

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2009 Contributo in volume (Capitolo o Saggio) GATTO B, GIARETTA G, BERTUZZI M, BIANCHINI E, ZAGOTTO G, PALUMBO M. (2009) a drug target. In: STEFANO ALCARO . NEW PERSPECTIVES IN MEDICINAL CHEMISTR p. 199-211, TRIVANDRUM:KERALA: RESEARCH SIGNPOST, ISBN: 9788130803210

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2008 Articolo in rivista PAN X.-S, DIAS M, PALUMBO M., FISHER L.M (2008). Clerocidin selectively modifies the gyrase-DNA gate to induce irreversible and reversible DNA damage. NUCLEIC ACIDS RES vol. 36, p. 5516-5529, ISSN: 0305-1048

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2008

Articolo in rivista Zagotto G, Sissi C, Moro S, Dal Ben D, Parkinson GN, Fox KR, Neidle S, Palumbo M (2008 bond direction modulates G-quadruplex recognition and telomerase inhibition by 2,6 and 2,7 bis-substituted anthracenedione derivatives.. BIOORGANIC & MEDICINAL CHEMISTRY, v 354-361, ISSN: 0968-0896, doi: 10.1016/j.bmc.2007.09.040

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2008

Articolo in rivista PIVETTA C, LUCATELLO L, KRAPCHO A.P, GATTO B, PALUMBO M., SISSI C (2008). Pe side chains modulate G-quadruplex conformation in biologically relevant DNA sequences. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, p. 9331-9339, ISSN: 0968-0896, doi: 10.1016/j.bmc.2008.08.068

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2008

Articolo in rivista GATTO B., VIANINI E, LUCATELLO L, SISSI C, MOLTRASIO D, PESCADOR R, PORTA PALUMBO M (2008). Effective DNA inhibitors of Cathepsin G by in vitro selection. INTERN JOURNAL OF MOLECULAR SCIENCES, vol. 9, p. 1008-1023, ISSN: 1422-0067, doi: 10.3390/ijms9061008

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2008

Articolo in rivista SISSI C, CHEMELLO A, VAZQUEZ E, MITCHENALL L. A, PALUMBO M. (2008). DNA gyra requires DNA for effective two-site coordination of divalent metal ions: further insight into th mechanism of enzyme action. BIOCHEMISTRY, vol. 47, p. 8538-8545, ISSN: 0006-2960, d 10.1021/bi800480j

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2008

Articolo in rivista BAZZICALUPI C, BENCINI A, BONACCINI C, GIORGI C, GRATTERI P, MORO S., PALU SIMIONATO A, SGRIGNANI J, SISSI C, VALTANCOLI B (2008). Tuning the activity of Zn(II complexes in DNA cleavage: Clues for design of new efficient metallo-hydrolases. INORGA CHEMISTRY, vol. 47, p. 5473-5484, ISSN: 0020-1669, doi: 10.1021/ic800085n

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2008

Articolo in rivista G. ZAGOTTO, C. SISSI, L. LUCATELLO, C. PIVETTA, S. A. CADAMURO, K. R. FOX, S.N PALUMBO M. (2008). Aminoacyl-anthraquinone conjugates as telomerase inhibitors: synth biophysical and biological evaluation. JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, p. 5566-5574, ISSN: 0022-2623, doi: 10.1021/jm800160v

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2008

Articolo in rivista ZAGOTTO G, SISSI C, MORO S, DAL BEN D, PARKINSON G.N, FOX K.R, NEIDLE S, PA M (2008). Amide bond direction modulates G-quadruplex recognition and telomerase inhibiti and 2,7 bis-substituted anthracenedione derivatives. BIOORGANIC & MEDICINAL CHEMIS 16, p. 354-361, ISSN: 0968-0896

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2007 Articolo in rivista VERGA D, RICHTER S.N, PALUMBO M., GANDOLFI R, FRECCERO M (2007). Bipyridyl li mildly activable mono- and bis-alkylating agents capable of DNA cross-linking. ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 10, p. 233-235, ISSN: 1477-0520, doi: 10.1039/B6162

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2007

Articolo in rivista DORIA F, RICHTER S., NADAI M, COLLOREDO-MELS S, MELLA M, PALUMBO M, FREC (2007). BINOL-amino acid conjugates as triggerable carriers of DNA-targeted potent photoc agents. JOURNAL OF MEDICINAL CHEMISTRY, vol. 50, p. 6570-6579, ISSN: 0022-2623, 10.1021/jm070828x

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2007

Articolo in rivista SISSI C., LUCATELLO L, KRAPCHO AP, MALONEY DJ, BOXER MB, CAMARASA MV, P G, MENTA E, PALUMBO M (2007). Tri-, tetra- and heptacyclic perylene analogues as new antineoplastic agents based on DNA telomerase inhibition. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 15, p. 555-562, ISSN: 0968-0896, doi: 10.1016/j.bmc.2006.09.029

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2007

Articolo in rivista DAL BEN D, CAPRANICO G, ZAGOTTO G, PALUMBO M., MORO S (2007). DNA topoiso structures and anthracycline activity: insights into ternary complex formation. CURRENT PHARMACEUTICAL DESIGN, vol. 13, p. 2766-2780, ISSN: 1381-6128, doi: 10.2174/138161207781757105

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2007

Articolo in rivista RICHTER S., GIARETTA G, COMUZZI V, LEO E, MITCHENALL LA, FISHER LM, MAXWE PALUMBO M (2007). Hot-spot consensus of fluoroquinolone-mediated DNA cleavage by gram-negative and gram-positive type II DNA topoisomerases. NUCLEIC ACIDS RESEAR 35, p. 6075-6085, ISSN: 0305-1048, doi: 10.1093/nar/gkm653

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2006

Articolo in rivista RICHTER S.N, LEO E, GIARETTA G, GATTO B, FISHER L.M, PALUMBO M. (2006). Clero interacts with the cleavage complex of Streptococcus pneumoniae topoisomerase IV to indu selective irreversible DNA damage. NUCLEIC ACIDS RESEARCH, vol. 34, p. 1982-1991, I 0305-1048, doi: 10.1093/nar/gkl127

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2006

Articolo in rivista CARTEI G, TRESTIN A, COLOMBRINO E, NADAI M, RICHTER SN, BARZON L, PALU' G. PALUMBO M (2006). Topoisomerase I, II-alpha and II-beta mRNA expression in peripheral mononuclear cells of patients with solid tumor: preliminary results. ANNALS OF ONCOLOG Suppl. 5, p. V25-V28, ISSN: 0923-7534, doi: 10.1093/annonc/mdj945

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2006

Articolo in rivista SISSI C., LUCATELLO L, NAGGI A, TORRI G, PALUMBO M (2006). Interactions of low-molecular-weight semi-synthetic sulfated heparins with human leukocyte elastase and h Cathepsin G. BIOCHEMICAL PHARMACOLOGY, vol. 71, p. 287-293, ISSN: 0006-2952, do 10.1016/j.bcp.2005.10.027

70

2006

Articolo in rivista RICHTER S.N, CARTEI G, NADAI M, TRESTIN A, BARZON L, PALUMBO M., PALU' G (20vitro basis for schedule-dependent interaction between gemcitabine and topoisomerase-tar drugs in the treatment of colorectal cancer. ANNALS OF ONCOLOGY, vol. 17 Suppl. 5, p. 2 ISSN: 0923-7534, doi: 10.1093/annonc/mdj944

71

2005 Articolo in rivista RICHTER S.N, GATTO B, TABARRINI O, FRAVOLINI A, PALUMBO M. (2005). Antiviral 6-amino-quinolones: Molecular basis for potency and selectivity.. BIOORGANIC & MEDICI CHEMISTRY LETTERS, vol. 15, p. 4247-4251, ISSN: 0960-894X, doi: 10.1016/j.bmcl.2005.

72

2005 Articolo in rivista RICHTER S, FABRIS D, MORO S, M. PALUMBO (2005). Dissecting reactivity of Clerocidin common buffer systems by means of selected drug analogues. CHEMICAL RESEARCH IN TOXICOLOGY, vol. 18, p. 35-40, ISSN: 0893-228X, doi: 10.1021/tx049858i

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2005 Articolo in rivista SISSI C., E MARANGON, A. CHEMELLO, C.G. NOBLE, A. MAXWELL, M. PALUMBO (200 effects of metal ions on the structure and stability of the DNA gyrase B protein. JOURNAL O MOLECULAR BIOLOGY, vol. 353, p. 1152-1160, ISSN: 0022-2836, doi: 10.1016/j.jmb.2005

74

2005 Articolo in rivista SISSI C., MANCIN F., GATOS M., PALUMBO M., TECILLA P., TONELLATO U. (2005). Effi Plasmid DNA Cleavage by a Mononuclear Copper(II) Complex. INORGANIC CHEMISTRY, p. 2310-2317, ISSN: 0020-1669, doi: 10.1021/ic049316o

75

2005

Articolo in rivista LEO E, GOULD KA, PAN XS, CAPRANICO G, SANDERSON MR, PALUMBO M., FISHER (2005). Novel symmetric and asymmetric DNA scission determinants for Streptococcus pne topoisomerase IV and gyrase are clustered at the DNA breakage site. THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 280, p. 14252-14263, ISSN: 0021-9258

76

2005

Brevetto M. PALUMBO, GATTO B., PESCADOR. R, PORTA R, FERRO L (2005). DNA-based ligand Human Cathepsin and medicaments thereof. WO2005003347 , Gentium SpA

77

2004

Articolo in rivista ORIANA TABARRINI, MIGUEL STEVENS, VIOLETTA CECCHETTI, STEFANO SABATINI, MICAELA DELLUOMO, GIUSEPPE MANFRONI, PALUMBO M., CHRISTOPHE PANNEC ERIK DE CLERCQ, ARNALDO FRAVOLINI (2004). Structure Modifications of 6-Aminoquin with Potent Anti-HIV Activity. JOURNAL OF MEDICINAL CHEMISTRY, vol. 47, p. 5567-557 0022-2623

78

2004

Articolo in rivista RICHTER S., PAROLIN C., GATTO B., DEL VECCHIO C., BROCCACOFANO E., FRAVOLPALU' G., PALUMBO M. (2004). Inhibition of human immunodeficiency virus type 1 Tat-trans-Activation-Responsive Region interaction by an antiviral quinolone derivative. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 48, p. 1895-1899, ISSN: 0066-48 10.1128/AAC.48.5.t895-1899.2004

79

2004

Articolo in rivista SISSI C., LEO E., MORO S., CAPRANICO G., MANCIA A., MENTA E., KRAPCHO A.P., P M. (2004). Antitumor AZA-anthrapyrazoles: biophysical and biochemical studies on 8-aza a regioisomers. BIOCHEMICAL PHARMACOLOGY, vol. 67, p. 631-642, ISSN: 0006-2952, d 10.1016/j.bcp.2003.09.035

80

2004 Articolo in rivista RICHTER S., FABRIS D., BINASCHI M., GATTO B., CAPRANICO G., PALUMBO M. (2004 of common buffer systems on drug activity: the case of clerocidin. CHEMICAL RESEARCH TOXICOLOGY, vol. 17, p. 492-501, ISSN: 0893-228X, doi: 10.1021/tx034210b

81

2004 Articolo in rivista MORO S., BERETTA GL, DAL BEN D, NITISS J, PALUMBO M, CAPRANICO G (2004). Int model for anthracycline activity against DNA topoisomerase II. BIOCHEMISTRY, vol. 43, p. 7503-7513, ISSN: 0006-2960

82

2004 Articolo in rivista CAPRANICO G., ZAGOTTO G., PALUMBO M. (2004). Development of DNA topoisomeras therapeutics: a short perspective of new challenges. . CURRENT MEDICINAL CHEMISTRY p. 335-345, ISSN: 0929-8673, doi: 10.2174/1568011043352885

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2004 Articolo in rivista RICHTER S., MAGGI S., COLLAREDO MELS S., PALUMBO M., FRECCERO M. (2004). B quinone methides as bis-alkylating and DNA cross-linking agents. JOURNAL OF THE AME CHEMICAL SOCIETY, vol. 126, p. 13973-13979, ISSN: 0002-7863, doi: 10.1021/ja047655a

84

2004 Articolo in rivista RICHTER S., PAROLIN C., PALUMBO M., PALU' G. (2004). Antiviral properties of quinolon drugs.. CURRENT DRUG TARGETS, vol. 4, p. 111-116, ISSN: 1389-4501, doi: 10.1128/AAC.48.5.t895-1899.2004

85

2004

Articolo in rivista ZAGOTTO G., SISSI C., GATTO B., PALUMBO M. (2004). Aminoacyl-analogues of Mitoxa novel DNA-damaging cytotoxic agents. ARKIVOC, vol. V, p. 204-218, ISSN: 1551-7004

86

2004

Articolo in rivista BOSEGGIA E., GATOS M., LUCATELLO L., MANCIN F., MORO S., PALUMBO M., SISSI TECILLA P., TONELLATO U., ZAGOTTO G. (2004). Toward efficient Zn(II)-based artificial nucleases. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 126, p. 4543-4549, I 0002-7863, doi: 10.1021/ja039465q

87

2004 Articolo in rivista SARA RICHTER, ILEANA MENEGAZZO, DANIELE FABRIS, PALUMBO M. (2004). Concerbis-alkylating reactivity of clerocidin towards unpaired cytosine residues in DNA. NUCLEIC RESEARCH, vol. 32, p. 5658-5667, ISSN: 0305-1048, doi: 10.1093/nar/gkh898

88

2004

Articolo in rivista PALUMBO M. (2004). Anticancer agents:towards the future. CURRENT MEDICINAL CHEM vol. 4, p. 425-428, ISSN: 0929-8673

89

2004 Articolo in rivista STEFANO MORO, GIOVANNI L. BERETTA, DIEGO DAL BEN, JOHN NITISS, PALUMBO GIOVANNI CAPRANICO (2004). An interaction model for anthracycline activity against DN topoisomerase II. BIOCHEMISTRY, vol. 43, p. 7503-7513, ISSN: 0006-2960

90

2004 Articolo in rivista SISSI C., M. PALUMBO (2004). Antitumor potential of aza-bioisosterism in anthracenedione drugs. CURRENT TOPICS IN MEDICINAL CHEMISTRY, vol. 4, p. 219-230, ISSN: 1568-02 10.2174/1568026043451483

91

2003

Articolo in rivista YU YEVDOKIMOV, V. SALYANOV, YU NECHIPURENKO, S. SKURIDIN, M. ZAKHAROV, SPENER, PALUMBO M. (2003). Molecular Constructions (Superstructures) with Adjustable Properties Based on Double-Stranded Nucleic Acids. MOLECULAR BIOLOGY, vol. 37, p. 2 ISSN: 0026-8933

92

2003 Articolo in rivista RICHTER S, GATTO B., FABRIS D, TAKAO KI, KOBAYASHI S, PALUMBO M (2003). Cler alkylates DNA through its epoxide function: evidence for a fine tuned mechanism of action. ACIDS RESEARCH, vol. 31, p. 5149-5156, ISSN: 0305-1048, doi: 10.1093/nar/gkg696

93

2003 Articolo in rivista RICHTER S., PALUMBO M. (2003). Alternative approaches to the discovery and developm telomerase-targeted anticancer drugs . MINI-REVIEWS IN MEDICINAL CHEMISTRY, vol. 3 37-50, ISSN: 1389-5575

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2003

Articolo in rivista SISSI C., A. NAGGI, G. TORRI, M. PALUMBO (2003). Modulation of Antithrombin-Protease Interactions by Semisynthetic Low-Molecular-Weight Heparins with Different Sulfation Patte SEMINARS IN THROMBOSIS AND HEMOSTASIS, vol. 29, p. 661-670, ISSN: 0094-6176, 10.1055/s-2004-815633

95

2003

Articolo in rivista PECERE T, SARINELLA F, SALATA C, GATTO B., BET A, DALLA VECCHIA F, DIASPRO M, PALUMBO M, PALU G (2003). Involvement of p53 in specific anti-neuroectodermal tumo of aloe-emodin. INTERNATIONAL JOURNAL OF CANCER, vol. 106, p. 836-847, ISSN: 00 doi: 10.1002/ijc.11312

96

2003

Articolo in rivista Evdokimov Y.M., Salyanov V.I., Nechipurenko Y.D., Skuridin S.G., Zakharov M.A., Spener Palumbo M. (2003). Molecular constructions (superstructures) with adjustable properties ba double-stranded nucleic acids. MOLEKULJARNAJA BIOLOGIJA, vol. 37, p. 340-355, ISSN: 0026-8984

97

2003

Articolo in rivista ANTONINI I, POLUCCI P, MAGNANO A, GATTO B., PALUMBO M, MENTA E, PESCALLI MARTELLI S (2003). Design, Synthesis and Biological Properties of New Bis(acridine-4-carboxamides) as Anticancer Agents. JOURNAL OF MEDICINAL CHEMIST 46, p. 3109-3115, ISSN: 0022-2623, doi: 10.1021/jm030820x

98

2003

Articolo in rivista PAROLIN C., GATTO B., DEL VECCHIO C., TRAMONTANO E., CECCHETTI V., FRAVOL MASIERO S., M. PALUMBO, PALU' G. (2003). New anti-human immunodeficiency type 1 6-aminoquinolones: mechanism of action. ANTIMICROBIAL AGENTS AND CHEMOTHERA47, p. 889-896, ISSN: 0066-4804, doi: 10.1128/AAC.47.3.889-896.2003

99

2003 Articolo in rivista SISSI C., M. PALUMBO (2003). The quinolone family: from antibacterial to anticancer agent CURRENT MEDICINAL CHEMISTRY, vol. 3, p. 439-450, ISSN: 1568-0118, doi: 10.2174/1568011033482279

100

2003

Brevetto PALUMBO M., GATTO B., PESCADOR R., PORTA R., FERRO L. (2003). DNA-based apta human cathepsin G . Brevetto Europeo 03425428.4, Gentium S.p.A.

101

2002 Articolo in rivista NICOLETTO M.O., PADRINI R., PALUMBO M., ZIADE A., PRATESI G., ARTIOLI G., DE C M., ZUNINO F. (2002). Intralesional topotecan in advanced ovarian cancer: A clinical report, on a preclinical study. ONCOLOGY REPORTS, vol. 9, p. 1351-1354, ISSN: 1021-335X

102

2002

Articolo in rivista SISSI C., LUCATELLO L., NAGGI A., TORRI G., PALUMBO M. (2002). Effects of Ca2+ ion interactions between antithrombin III and factor Xa mediated by variously-sulfated semi-synt low-molecular-weight heparins. SEMINARS IN THROMBOSIS AND HEMOSTASIS, vol. 28, 355-361, ISSN: 0094-6176

103

2002

Articolo in rivista ANTONINI I., POLUCCI P., MAGNANO A., GATTO B., PALUMBO M., MENTA E., PESCAL MARTELLI S. (2002). 2,6-di(omega-aminoalkyl)-2,5,6,7-tetrahydropyrazolo[3,4,5-mn]pyrimido[5,6,1-de]-acridine-5 Novel, potent, cytotoxic, and DNA-binding agents. JOURNAL OF MEDICINAL CHEMISTRY p. 696-702, ISSN: 0022-2623, doi: 10.1021/jm011004x

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2002

Articolo in rivista PALUMBO M, GATTO B., MORO S, SISSI C, ZAGOTTO G. (2002). Sequence specific inte drugs interfering with topoisomerase-DNA cleavage complex. BIOCHIMICA ET BIOPHYSIC MOLECULAR BASIS OF DISEASE, vol. 1587, p. 145-154, ISSN: 0925-4439, doi: 10.1016/S0925-4439(02)00077-7

105

2002 Contributo in volume (Capitolo o Saggio) M. PALUMBO, B. GATTO, SISSI C. (2002). DNA topoisomerase-targeted drugs. In: M. DEMEUNYNCH; C. BAILLY; W. D. WILSON. DNA AND RNA BINDERS: FROM SMALL MOLECULES TO DRUGS. vol. 2, p. 503-537, Wiley-VCH

106

2001

Articolo in rivista PEREGO P., DE CESARE M., DE ISABELLA P., CARENINI N., BEGGIOLIN G., PEZZONI PALUMBO M., PRATESI G., PISANO C., CARMINATI P, SCHEFFER G., ZUNINO F. (200 novel 7-modified camptothecin analog overcomes breast cancer resistance protein-associat resistance in a mitoxantrone-selected colon carcinoma cell line. CANCER RESEARCH, vol. 6034-6037, ISSN: 0008-5472

107

2001 Articolo in rivista SISSI C., NAGGI A., TORRI G., PALUMBO M. (2001). Effects of Sulfation on Antithrombin-Thrombin/Factor Xa Interactions in Semisynthetic Low-Molecular Weight Hepa SEMINARS IN THROMBOSIS AND HEMOSTASIS, vol. 27, p. 483-487, ISSN: 0094-6176

108

2001 Articolo in rivista C. SISSI, P. ROSSI, F. FELLUGA, FORMAGGIO F., M. PALUMBO, P. TECILLA, C. TONIO SCRIMIN (2001). Dinuclear Zn2+ complexes of synthetic heptapeptides as artificial nucleas JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 123, p. 3169-3170, ISSN: 0002

109

2001 Articolo in rivista VIANINI E, PALUMBO M, GATTO B. (2001). In vitro Selection of DNA Aptamers that Bind L-Tyrosinamide . BIOORGANIC & MEDICINAL CHEMISTRY, vol. 9, p. 2543-2548, ISSN: 0 doi: 10.1016/S0968-0896(01)00054-2

110

2001 Articolo in rivista FERLIN M.G., GATTO B., CHIARELOTTO G., PALUMBO M. (2001). Novel pyrrolo [3,2-f]qusynthesis and antiproliferative activity. BIOORGANIC & MEDICINAL CHEMISTRY, vol. 9, p. 1843-1848, ISSN: 0968-0896

111

2001

Articolo in rivista GATTO B., RICHTER S., MORO S., CAPRANICO G., M. PALUMBO (2001). The topoisom poison clerocidin alkylates non-paired guanines of DNA: implications for the irreversible stim DNA cleavage. NUCLEIC ACIDS RESEARCH, vol. 29, p. 4224-4230, ISSN: 0305-1048, doi 10.1093/nar/29.20.4224

112

2001 Articolo in rivista PALUMBO M, SISSI C, GATTO B., MORO S, ZAGOTTO G (2001). Quantitation of camptot related compounds. JOURNAL OF CHROMATOGRAPHY B. BIOMEDICAL SCIENCES AN APPLICATIONS, vol. 764, p. 121-140, ISSN: 1387-2273, doi: 10.1016/S0378-4347(01)0034

113

2001

Articolo in rivista SUPINO R, POLIZZI D, PAVESI R, PRATESI G, GUANO F, CAPRANICO G, PALUMBO M S. RICHTER, BEGGIOLIN G, MENTA E, PEZZONI G, SPINELLI S, TORRIANI D, CARENI BO L, FACCHINETTI F, TORTERETO M, ZUNINO F (2001). A novel 9-aza-anthrapyrazole against human prostatic carcinoma xenografts. ONCOLOGY, vol. 61, p. 234-242, ISSN: 00

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114 2001

Articolo in rivista SISSI C, MORO S, RICHTER S, GATTO B., MENTA E, SPINELLI S, KRAPCHO A, ZUNIN PALUMBO M (2001). DNA-Interactive Anticancer Aza-Anthrapyrazoles: Biophysical and Bio Studies Relevant to the Mechanism of Action. MOLECULAR PHARMACOLOGY, vol. 59, p. ISSN: 0026-895X

115 2001 Articolo in rivista SISSI C., PERDONA' E, DOMENICI E., FERIANI A.., HOWELLS A.J., MAXWELL A., PALU (2001). Ciprofloxacin affects conformational equilibria of DNA gyrase A in the presence of magnesium ions . JOURNAL OF MOLECULAR BIOLOGY, vol. 311, p. 195-203, ISSN: 0022

116 2001

Articolo in rivista G. ZAGOTTO, B. GATTO, S. MORO, SISSI C., M. PALUMBO (2001). Antracyclines: recent developments in their separation and quantitation. JOURNAL OF CHROMATOGRAPHY B. BIOMEDICAL SCIENCES AND APPLICATIONS, vol. 764, (1-2), p. 161-171, ISSN: 1387-22 10.1016/S0378-4347(01)00346-2

117 2000

Articolo in rivista NICOLETTO M.O., PADRINI R., GALEOTTI F., FERRAZZI E., CARTEI G., RIDDI F., PALU DE PAOLI M., CORSINI A. (2000). Pharmacokinetics of intraperitoneal hyperthermic perfusi mitoxantrone in ovarian cancer. CANCER CHEMOTHERAPY AND PHARMACOLOGY, vol. 457-462, ISSN: 0344-5704

118 2000

Articolo in rivista Evdokimov Y.M., Salyanov V.I., Mchedlischvili B.V., Belyaev A.V., Saunin S.A., Spener F., P M. (2000). Double-stranded nucleic acids in liquid-crystalline dispersions as building blocks cross-linked supramolecular structures. NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACID 19, p. 1355-1364, ISSN: 1525-7770

119 2000 Articolo in rivista O. TABARRINI, SISSI C., A FRAVOLINI, M. PALUMBO (2000). 6-hydroxy derivatives as Ne Desfluoroquinolone (DFQ): synthesis and DNA-binding study. NUCLEOSIDES, NUCLEOTI NUCLEIC ACIDS, vol. 19, p. 1327-1336, ISSN: 1525-7770

120 2000 Articolo in rivista FERLIN M.G., GATTO B., CHIARELOTTO G., PALUMBO M. (2000). Pyrroloquinoline deriv potential antineoplastic drugs . BIOORGANIC & MEDICINAL CHEMISTRY, vol. 8, p. 1415-1 ISSN: 0968-0896

121 2000 Articolo in rivista Zagotto G., Supino R., Favini E., Moro S., Palumbo M. (2000). New 1,4-anthracene-9,10-dio derivatives as potential anticancer agents. IL FARMACO, vol. 55, p. 1-5, ISSN: 0014-827X, 10.1016/S0014-827X(99)00091-9

122 2000

Articolo in rivista SISSI C., MANCIN F., PALUMBO M., SCRIMIN P., TECILLA P., TONELLATO U. (2000). D phosphodiester bond hydrolysis mediated by Cu(II) and Zn(II) complexes of 1,3,5-triaminocyclohexane derivatives . NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACID 19, p. 1265-1271, ISSN: 1525-7770

123 2000

Articolo in rivista V. CECCHETTI, C. PAROLIN, S. MORO, PECERE T., E. FILIPPONI, A. CALISTRI, O. TAB B. GATTO, M. PALUMBO, A. FRAVOLINI, G. PALU' (2000). 6-aminoquinolones as new pot anti-HIV agents. JOURNAL OF MEDICINAL CHEMISTRY, vol. 43(20), p. 3799-3802, ISSN: 0022-2623, doi: 10.1021/jm9903390

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1999

Articolo in rivista SISSI C., MORO S., G. ZAGOTTO, ELLIS M., KRAPCHO P., MENTA E., PALUMBO M (19 Binding of bis-substituted 2-aza-anthracenedione regioisomers to DNA: effects of the relativ positioning of the side chains.. ANTI-CANCER DRUG DESIGN, vol. 14 (3), p. 265-274, ISS 0266-9536

125

1999 Articolo in rivista GATTO B, CAPRANICO G, M. PALUMBO (1999). Drugs acting on DNA topoisomerases: R advances and future perspectives. CURRENT PHARMACEUTICAL DESIGN, vol. 5, p. 195-ISSN: 1381-6128

126

1999 Articolo in rivista STUDZIAN K., TOLWINSKASTANCZYK Z., WILMANSKA D., M. PALUMBO, GNIAZDOWS (1999). Crosslinking of cellular DNA by nitracrine and furocoumarin derivatives. NEOPLAS 46, p. 50-53, ISSN: 0028-2685

127

1998

Articolo in rivista MENTA E, M. PALUMBO (1998). Antineoplastic agents 1998. EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 8, p. 1627-1672, ISSN: 1354-3776

128

1998 Articolo in rivista Zagotto G., Palumbo M., Uriarte E., Bonsignore L., De Logu G., Podda G. (1998). Synthesis 2H,9H-naphtho[2,3-b:7,6-b']dipyran-2,9-diones as potential DNA-reactive agents. IL FARMA 53, p. 675-679, ISSN: 0014-827X, doi: 10.1016/S0014-827X(98)00085-8

129

1998

Articolo in rivista Zagotto G., Oliva A., Guano F., Menta E., Capranico G., Palumbo M. (1998). Synthesis, DNA-damaging and cytotoxic properties of novel topoisomerase II-directed bisantrene analo BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 8, p. 121-126, ISSN: 0960-894X 10.1016/S0960-894X(97)10207-4

130

1998 Articolo in rivista G. ZAGOTTO, MITARITONNA G., SISSI C., PALUMBO M. (1998). New peptidyl-anthraquin Synthesis and DNA binding. NUCLEOSIDES & NUCLEOTIDES, vol. 17 (9-11), p. 2135-214 0732-8311, doi: 10.1080/07328319808004756

131

1998 Articolo in rivista MARCAZZAN M., B. GATTO, SISSI C, ZAGOTTO G, CAPRANICO G., PALUMBO M (1998insight into the Zn2+-mediated binding of streptonigrin to DNA. IL FARMACO, vol. 53, p. 64 ISSN: 0014-827X, doi: 10.1016/S0014-827X(98)00080-9

132

1998

Articolo in rivista C. SISSI, L. BOLGAN, S. MORO, G. ZAGOTTO, C. BAILLY, E. MENTA, G. CAPRANICO, PALUMBO (1998). DNA-binding preferences of bisantrene analogues: Relevance to the se specificity of drug-mediated topoisomerase II poisoning. MOLECULAR PHARMACOLOGY, (6), p. 1036-1045, ISSN: 0026-895X

133

1998

Articolo in rivista CAPRANICO G., GUANO F., MORO S., ZAGOTTO G., SISSI C., GATTO B., ZUNINO F., E., M. PALUMBO (1998). Mapping drug interactions at the covalent topoisomerase II-DNA c by bisantrene/amsacrine congeners. THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 2 12732-12739, ISSN: 0021-9258, doi: 10.1074/jbc.273.21.12732

134

1998 Articolo in rivista SISSI C, ANDREOLLI M, CECCHETTI V, FRAVOLINI A, GATTO B, M. PALUMBO (1998). Mg2+-mediated binding of 6-substituted quinolones to DNA: Relevance to biological activity BIOORGANIC & MEDICINAL CHEMISTRY, vol. 6, p. 1555-1561, ISSN: 0968-0896

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1998

Articolo in rivista Y. YEVDOKIMOV, Y. SALYANOV, Lortkipanigz GB, E. GEDIG, F. SPENER, M. PALUMBO Sensing biological effectors through the response of bridged nucleic acids and polynucleotid in liquid-crystalline dispersions. BIOSENSORS & BIOELECTRONICS, vol. 13, p. 279-291, I 0956-5663, doi: 10.1016/S0956-5663(97)00133-4

136

1998 Abstract in rivista RICHTER S, ZAGOTTO G, B. GATTO, BINASCHI M, CAPRANICO G, PALUMBO M (1998 Interaction between the cytotoxic drug Clerocidin and DNA: evidence for covalent adduct for EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 6-S1, p. S57, ISSN: 092

137

1998 Contributo in volume (Capitolo o Saggio) Capranico G., Binaschi M., Borgnetto M.E., Zunino F., Cornarotti M., Zagni E., Palumbo M. Sequence-specific poisons of type II DNA topoisomerases. In: M. Palumbo. DNA sequence agents. vol. 3, p. 7-38, doi: 10.1016/S1067-568X(98)80004-2

138

1998

Contributo in volume (Capitolo o Saggio) M. Palumbo (1998). Introduction to DNA sequence-specific agents. In: M. Palumbo. Advanc DNA Sequence Specidic Agents. vol. 3, p. 1-6, doi: 10.1016/S1067-568X(98)80003-0

139

1998

Monografia o trattato scientifico Palumbo M. (1998). Advances in DNA sequence specific agents. vol. 3, p. 1-283, Elsevier S ISBN: 9780762302031

140

1997

Articolo in rivista P. DE ISABELLA, M. PALUMBO, C. SISSI, N. CARENINI, G. CAPRANICO, E. MENTA, A. SPINELLI, KRAPCHO A.P, GIULIANI F.C, ZUNINO F (1997). Physicochemical properties, activity and topoisomerase II inhibition of 2,3-diaza-anthracenediones . BIOCHEMICAL PHARMACOLOGY, vol. 53, p. 161-169, ISSN: 0006-2952

141

1997 Articolo in rivista De Logu, G., Maccioni E., Palumbo M., Podda G., Zagotto G. (1997). Synthesis of a new cl pharmaceutically relevant naphtyridines. BOLLETTINO CHIMICO FARMACEUTICO, vol. 1 334-335, ISSN: 0006-6648

142

1997 Articolo in rivista CAPRANICO G., BINASCHI M., BORGNETTO M.E., ZUNINO F., M. PALUMBO (1997). A protein-mediated mechanism for the DNA sequence-specific action of topoisomerase II pois TRENDS IN PHARMACOLOGICAL SCIENCES, vol. 18, p. 323-329, ISSN: 0165-6147

143

1997 Articolo in rivista ZAGOTTO G, S. MORO, URIARTE E, FERRAZZI E, PALU G, PALUMBO M (1997). Amido of mitoxantrone: physico chemical properties, molecular modeling, cellular effects and antin potential. ANTI-CANCER DRUG DESIGN, vol. 12(2), p. 99-112, ISSN: 0266-9536

144

1997

Articolo in rivista MENTA E, M. PALUMBO (1997). Novel antineoplastic agents. EXPERT OPINION ON THERAPEUTIC PATENTS, vol. 7, p. 1401-1426, ISSN: 1354-3776

145

1997 Articolo in rivista Y. YEVDOKIMOV, V. SALYANOV, L BULIGIN, E. GEDIG, F, SPENCER, M. PALUMBO (19 Liquid-crystalline structure of nucleic acids: Effect of antracycline drugs and copper ions. JO OF BIOMOLECULAR STRUCTURE & DYNAMICS, vol. 15, p. 97-105, ISSN: 0739-1102

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146

1997

Articolo in rivista B. GATTO, ZAGOTTO G, SISSI C, PALUMBO M (1997). Preferred interaction of D-peptidyl-anthraquinones with double-stranded B-DNA. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, vol. 21, p. 319-326, ISSN: 0141-8130, doi: 10.1016/S0141-8130(97)00076-7

147

1997

Articolo in rivista BINASCHI M, ZAGOTTO G, M. PALUMBO, ZUNINO F, FARINOSI R, CAPRANICO G (199 Irreversible and reversible topoisomerase II DNA cleavage stimulated by clerocidin: Sequen specificity and structural drug determinants. CANCER RESEARCH, vol. 57, p. 1710-1716, I 0008-5472

148

1996

Articolo in rivista BOARO M, CORAIN B, JERABEK K, LORA S, PALMA G, PALUMBO M, M. ZECCA (1996) route to designable chiral macromolecular supports: Implications for supported metal cataly JOURNAL OF MOLECULAR CATALYSIS. A: CHEMICAL, vol. 109, p. L81-L84, ISSN: 1381 doi: 10.1016/1381-1169(96)00046-5

149

1996

Articolo in rivista Evdokimov Y.M., Salyanov V.I., Spener F., Palumbo M. (1996). Adjustable 'cross-linking' of neighboring DNA molecules in liquid-crystalline dispersions through (daunomycin-copper) p chelate complexes. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 247-255, ISSN: 0141-8130, doi: 10.1016/S0141-8130(96)01134-8

150

1996 Articolo in rivista Barlocco D., Bergomi M., Menta E., Palumbo M., Cignarella G. (1996). Tricyclic indenopyrid derivatives: Synthesis, cytotoxic activity and DNA-binding properties. RECUEIL DES TRAV CHIMIQUES DES PAYS-BAS, vol. 115, p. 25-30, ISSN: 0165-0513

151

1996

Articolo in rivista B. GATTO, G. ZAGOTTO, C. SISSI, C. CERA, E. URIARTE, G. PALU, G. CAPRRANICO, PALUMBO (1996). Peptidyl anthraquinones as potential antineoplastic drugs: synthesis, DNA-binding, redox cycling and biological activity. JOURNAL OF MEDICINAL CHEMISTRY p. 3114-3122, ISSN: 0022-2623, doi: 10.1021/jm950924a

152

1996 Articolo in rivista C. SISSI, G. CAPRANICO, E. MENTA, M. PALUMBO (1996). Aza-bioisosteres of 9,10-anthracenedione: a modulation of DNA sequence specificity. MOLECULAR PHARMA vol. 50, p. 838-845, ISSN: 0026-895X

153

1996 Articolo in rivista CECCHETTI V., FRAVOLINI A., M. PALUMBO, SISSI C., TABARRINI O., TERNI P., XIN T.Potent 6-desfluoro-8-methylquinolones as new lead compounds in antibacterial chemothera JOURNAL OF MEDICINAL CHEMISTRY, vol. 39, p. 4952-4957, ISSN: 0022-2623

154

1996

Contributo in volume (Capitolo o Saggio) G. ZAGOTTO, PALUMBO M. (1996). Gli aptameri. In: CASCINO A.; NICOLIN A.. Gli oligon sintetici: principi e applicazioni. p. 211-218, Utet

155

1995

Articolo in rivista C. A. GANDOLFI, G. BEGGIOLIN, E. MENTA, M. PALUMBO, C. SISSI, S. SPINELLI, F. JO (1995). Chromophore-modified antitumor anthracenediones: synthesis, DNA binding and cy activity of 1,4-bis[(aminoalkil)amino]benzo [g]phthalazine-5,10-diones. JOURNAL OF MEDI CHEMISTRY, vol. 38, p. 526-536, ISSN: 0022-2623

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1995 Articolo in rivista Zatta P., Zambenedetti P., Marturano M.B., Palumbo M., Nicolini M. (1995). Effects of Tacri murine neuroblastoma cells. JOURNAL OF NEURAL TRANSMISSION, vol. 102, p. 113-12 0300-9564

157

1995

Articolo in rivista Maccioni E., Delogu G., Podda G., Palumbo M., Zagotto G., Seraglia R., Traldi P. (1995). F bombardment mass spectrometry of some pharmacologically relevant anthraquinone deriva RAPID COMMUNICATIONS IN MASS SPECTROMETRY, vol. 9, p. 167-174, ISSN: 0951-4 10.1002/rcm.1290090212

158

1995

Articolo in rivista NICOLETTO MO, R. PADRINI, KOUSSIS H, ROSABIAN A, AVERSA S, ENDRIZZI L, AZZ PALUMBO M, FIORENTINO MV (1995). CONTINUOUS MITOXANTRONE INFUSION IN PRETREATED EPITHELIAL OVARIAN-CANCER. CANCER CHEMOTHERAPY AND PHARMACOLOGY, vol. 35, p. 506-510, ISSN: 0344-5704

159

1995

Articolo in rivista P. DE ISABELLA, M. PALUMBO, G. CAPRANICO, C. SISSI, E. MENTA, S. SPINELLI, N. CARONINI, A. D. KRAPCHO, F. C. GIULIANI, F. ZUNINO (1995). Topoisomerase II DNA cl stimulation, DNA binding activity, cytotoxicity and physico-chemical properties of 2-aza and 2-aza-oxide-anthracenedione derivatives. MOLECULAR PHARMACOLOGY, vol. 30, p. 30- 0026-895X

160

1994

Articolo in rivista Palumbo M., Mabilia M., Pozzan A., Capranico G., Tinelli S., Zunino F. (1994). Conformatio determinants of the sequence specificity of drug-stimulated topoisomerase II DNA cleavage. JOURNAL OF MOLECULAR BIOLOGY, vol. 235, p. 1218-1230, ISSN: 0022-2836, doi: 10.1006/jmbi.1994.1075

161

1994 Articolo in rivista Palumbo M., Mabilia M., Pozzan A., Capranico G., Tinelli S., Zunino F. (1994). Conformatio properties of topoisomerase II inhibitors and sequence specificity of DNA cleavage. JOURN MOLECULAR RECOGNITION, vol. 7, p. 227-231, ISSN: 0952-3499

162

1994 Articolo in rivista Capranico G., Palumbo M., Tinelli S., Zunino F. (1994). Unique sequence specificity of topoisomerase II DNA cleavage stimulation and DNA binding mode of streptonigrin. JOURN BIOLOGICAL CHEMISTRY, vol. 269, p. 25004-25009, ISSN: 1083-351X

163

1993

Articolo in rivista Guendalina Trovò, Bruno Longato, Benedetto Corain, Andrea Tapparo, Ariella Furlani, Vito Francarosa Baccichetti, Franco Bordin, Manlio Palumbo (1993). Remarkable lack of biologic exhibited by a dna-reactive and water-soluble cis-bis(phosphino) platinum(II) complex. JOU THE CHEMICAL SOCIETY DALTON TRANSACTIONS, p. 1547-1550, ISSN: 0300-9246, d 10.1039/dt9930001547

164

1993

Articolo in rivista P. DE ISABELLA, G. CAPRANICO, M. PALUMBO, C. SISSI, A. P. KRAPCHO, F. ZUNINO Sequence selectivity of Topoisomerase II DNA cleavage stimulated by Mitoxantrone derivati relationships with drug DNA binding and cellular effects. MOLECULAR PHARMACOLOGY, p. 715-721, ISSN: 0026-895X

165

1993 Articolo in rivista O. GIA, S. MOBILIO, M. PALUMBO, M.A.PATHAK (1993). Benzo- and tetrahydrobenzo-ps congeners: DNA binding and photobiological properties. PHOTOCHEMISTRY AND PHOTOBIOLOGY, vol. 57, No. 3, p. 497-503, ISSN: 0031-8655

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166 1993 Articolo in rivista PALUMBO M, GATTO B, ZAGOTTO G, PALU' G (1993). On the mechanism of action of qu drugs. TRENDS IN MICROBIOLOGY, vol. 1, p. 232-235, ISSN: 0966-842X, doi: 10.1016/0966-842X(93)90138-H

167 1993 Articolo in rivista G. Zagotto, O. Gia, F. Baccichetti, E. Uriarte, M. Palumbo. (1993). Synthesis and photobiolo properties of 4- hydroxymethyl-4'- methylpsoralen derivatives.. PHOTOCHEMISTRY AND PHOTOBIOLOGY, vol. 58, p. 486-491, ISSN: 0031-8655, doi: 10.1111/j.1751-1097.1993.tb

168 1993 Articolo in rivista PALU' G., TOGNON M., ROMANELLI M.G., RASSU M., PAROLIN C., ZAGOTTO G., PALU (1993). Relevance of DNA-binding to the mechanism of anti-herpesvirus activity of benzhyd ANTIVIRAL RESEARCH, vol. 20, p. 305-316, ISSN: 0166-3542, doi: 10.1016/0166-3542(93

169 1993

Articolo in rivista ANTONELLO C., URIARTE E., PALUMBO M., VALISENA S., PAROLIN C., PALU' G. (1993 Synthesis and biological activity of new quinolone derivatives. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 28, p. 291-296, ISSN: 0223-5234, doi: 10.1016/0223-5234(93)90146-6

170 1993 Articolo in rivista Nicoletto M.O., Padrini R., Ferrazzi E., Nascimben O., Visona E., Tumolo S., Palumbo M., C Vinante O., Monfardini S. (1993). Phase I-II intraperitoneal mitoxantrone in advanced pretre ovarian cancer . EUROPEAN JOURNAL OF CANCER, vol. 29, p. 1225-1226, ISSN: 0959-8

171 1993 Articolo in rivista Salyanov V.I., Palumbo M., Evdokimov Y.M. (1993). Formation of complexes of different typ anthraquinone-DNA interaction. MOLEKULJARNAJA BIOLOGIJA, vol. 27, p. 869-879, ISSN 0026-8984

172 1992 Articolo in rivista Cera C., Palumbo M., Stefanelli S., Rassu (1992). Water-soluble polysaccharide-anthracycli conjugates: Biological activity. ANTI-CANCER DRUG DESIGN, vol. 7, p. 143-151, ISSN: 02

173 1992 Articolo in rivista Zagotto G., Uriarte E., Antonello C., Conconi M.T., Magno S.M., Palumbo M. (1992). New hydroxy-amido-anthraquinones as potential antineoplastic drugs. BIOORGANIC & MEDICIN CHEMISTRY LETTERS, vol. 2, p. 659-662, ISSN: 0960-894X, doi: 10.1016/S0960-894X(00

174 1992 Articolo in rivista Salyanov V.I., Palumbo M., Evdokimov Y.M. (1992). Enzyme splitting of superhelical DNA u liquid-crystalline packing. MOLEKULJARNAJA BIOLOGIJA, vol. 26, p. 1036-1046, ISSN: 00

175 1992 Articolo in rivista O. GIA, S. MARCIANI MAGNO, A.GARBESI, F.P.COLONNA, M.PALUMBO (1992). Sequen specificity of psoralen photobinding to DNA: a quantitative approach. BIOCHEMISTRY, vol. 47, p. 11818-11822, ISSN: 0006-2960, doi: 10.1021/bi00162a021

176 1992 Articolo in rivista PALU' G, VALISENA S, CIARROCCHI G, B. GATTO, PALUMBO M (1992). Quinolone bindi DNA is mediated by magnesium ions. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 89, p. 9671-9675, ISSN: 0027-84

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1991 Articolo in rivista PALU' G, VALISENA S, PAROLIN C, CIARROCCHI G, GATTO B, PALUMBO M (1991). Fu insight into the mechanism of action of quinolones. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, vol. SI, p. 350-351, ISSN: 0934-9723

178

1991 Articolo in rivista Cera C., Palu' G., Marciani M.S., Palumbo M. (1991). Interaction between second generatio anthracyclines and DNA in the nucleosomal structure. NUCLEIC ACIDS RESEARCH, vol. 1 2309-2314, ISSN: 0305-1048

179

1991 Articolo in rivista Cera C., Palumbo M. (1991). The peculiar binding properties of 4'-deoxy,4'-iododoxorubicin isolated DNA and 175 bp nucleosomes. NUCLEIC ACIDS RESEARCH, vol. 19, p. 5707-57 0305-1048

180

1991 Articolo in rivista Rassu M., Ferrazzi E., Stefanelli S., Palu' G., Antonello C., Palumbo M. (1991). Structure-ac relationship of several mitoxantrone analogues [Correlazioni struttura-attività di alcuni analo mitoxantrone.]. GIORNALE ITALIANO DI CHEMIOTERAPIA, vol. 38, p. 201-203, ISSN: 001

181

1991

Articolo in rivista A. LAPOLLA, GERHARDINGER C., CREPALDI G., FEDELE D., PALUMBO M., DAL ZOPP PORTER C.J., GHEZZO E., SERAGLIA R., TRALDI P. (1991). Mass spectrometic approac structural identification of reaction products arising from the interaction between glucose an TALANTA, vol. 38 (4), p. 405-412, ISSN: 0039-9140, doi: 10.1016/0039-9140(91)80078-E

182

1990 Articolo in rivista Yevdokimov Y.M., Skuridin S.g., salyanov V.I., Rybin V.K., Palumbo M. (1990). Principles of biodetectors based on liquid crystals of nucleic acids. BIOPHYSICS, vol. 35, p. 755-764, IS 0360-019X

183

1990

Articolo in rivista Cera C, Palumbo M (1990). Anti-cancer activity of anthracycline antibiotics and DNA conde ANTI-CANCER DRUG DESIGN, vol. 5, p. 265-271, ISSN: 0266-9536

184

1990

Articolo in rivista M. Palumbo, F. Baccichetti, C. Antonello, O. Gia, A. Capozzi, S. Marciani Magno (1990). Photobiological activity of 3,4'-dimethyl-8-methoxypsoralen, a linear furocoumarin with unus DNA-binding properties. PHOTOCHEMISTRY AND PHOTOBIOLOGY, vol. 52, p. 533-540, 0031-8655

185

1990

Articolo in rivista PAROLIN C., MONTECUCCO A., CIARROCCHI G., PEDRALY-NOY G., VALISENA S., PA M., PALU' G. (1990). The effect of the minor groove binding agent DAPI (4', 6-diamidino-2-phenyl-indole) on DNA-directed enzymes: an attempt to explain inhibition of p expression in Escherichia coli. FEMS MICROBIOLOGY LETTERS, vol. 68, p. 341-346, ISS 0378-1097, doi: 10.1111/j.1574-6968.1990.tb13962.x

186

1990 Articolo in rivista VALISENA S., PALUMBO M., M. PAROLIN, PALU' G., MELONI G.A. (1990). Relevance of effects on norfloxacin uptake by Escherichia coli. BIOCHEMICAL PHARMACOLOGY, vol. 4 431-436, ISSN: 0006-2952, doi: 10.1016/0006-2952(90)90540-2

187

1990 Articolo in rivista Palumbo M., Marciani Magno S. (1990). Monofunctional Psoralen Derivatives: DNA binding photochemical potential. TRENDS IN PHOTOCHEMISTRY & PHOTOBIOLOGY, vol. 1, p. 2 ISSN: 0972-4532

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1990 Articolo in rivista Evdokimov IuM, Skuridin SG, Salianov VI, Rybin VK, Palumbo M (1990). Principles of creati biotransducers based on nucleic acid liquid crystals. BIOFIZIKA, vol. 35, p. 731-738, ISSN: 0006-3029

189

1990 Articolo in rivista Salyanov V.I., Evdokimov Y., Palumbo M. (1990). Investigation of properties of condensed f complexes of linear and circular superstranded DNA with mitroxantrone and bisantrene. ANTIBIOTICS AND CHEMOTHERAPY, vol. 35, p. 19-22, ISSN: 0066-4758

190

1990

Articolo in rivista Cera C., Palumbo M., Palu' G., Crothers D.M. (1990). N-methylmitomycin A cross-linking to nucleosomal structure. ANTI-CANCER DRUG DESIGN, vol. 5, p. 55-58, ISSN: 0266-9536

191

1990 Contributo in volume (Capitolo o Saggio) PALUMBO M, B. GATTO (1990). Aminoacyl-anthraquinones: DNA-binding and sequence s In: PULLMAN B and Jortner J. DNA sequence specific agents. p. 207-224, --Netherlands: S Netherlands -Dordrecht Netherlands:Kluwer Academic Publishers

192

1989 Articolo in rivista A. GUIOTTO, A. CHILIN, G. PASTORINI, M. PALUMBO (1989). Methylfuroquinolinones: ne furocoumarin isosters as potential photoreagents toward DNA.. JOURNAL OF HETEROCY CHEMISTRY, vol. 26, p. 917-922, ISSN: 0022-152X

193

1989 Articolo in rivista Yevdokimov Y.M., Skuridin S.G., Salyanov V.I., Semeikin A.S., Palumbo M. (1989). Nucleic a basis for creating biosensors. MOLEKULJARNAJA BIOLOGIJA, vol. 23, p. 1581-1588, IS 0026-8984

194

1989 Articolo in rivista Salyanov V.I., Prasolov V.S., Palumbo M., Yevdokimov Yu. M. (1989). Anomalous optical a induced on condensation of different spatial forms of double-chain ring DNA. BIOPHYSICS, p. 15-24, ISSN: 0360-019X

195

1989 Articolo in rivista Antonello C., Uriarte E., Palumbo M. (1989). Diethylaminopropionamido-hydroxy-anthraquin potential anticancer agents: Synthesis and characterization. ARCHIV DER PHARMAZIE, vo 541-544, ISSN: 1521-4184

196

1989 Articolo in rivista Salianov V.I., Prasolov V.S., Palumbo M., Evdokimov I.M. (1989). Anomalous optical activit during condensation of various spatial forms of double-stranded circular DNA . BIOFIZIKA, 20-27, ISSN: 0006-3029

197

1989

Articolo in rivista Gava C., Perazzolo M., Zentilin L., Levis A.G., Corain B., Bombi G.G., Palumbo M., Zatta P. Genotoxic potentiality and DNA binding properties of Acetylacetone, Maltol, and their alumin and chromium(III) neutral complexes. TOXICOLOGICAL AND ENVIRONMENTAL CHEMIS 22, p. 149-157, ISSN: 0277-2248

198

1988 Articolo in rivista Cera C., Terbojevich M., Cosani A., Palumbo M. (1988). Anthracycline antibiotics supported water-soluble polysaccharides: Synthesis and physicochemical characterization. INTERNA JOURNAL OF BIOLOGICAL MACROMOLECULES, vol. 10, p. 66-74, ISSN: 0141-8130

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1988 Articolo in rivista Palumbo M, Cera C, Marciani-Magno S, Palù G (1988). Interaction of nucleosomes with anthracycline antibiotics: relevance to anticancer activity.. BIOCHEMICAL PHARMACOLO 37, p. 1871-1872, ISSN: 0006-2952

200

1988 Articolo in rivista O. GIA, S. MOBILIO, A. CHILIN, P. RODIGHIERO, M. PALUMBO (1988). Pyrrolocoumarin derivatives: DNA-binding properties. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIO B-BIOLOGY, vol. 2, p. 435-442, ISSN: 1011-1344, doi: 10.1016/1011-1344(88)85072-3

201

1988 Articolo in rivista Antonello C., Uriarte E., Palumbo M. (1988). New anthracenediones with potential anticanc Synthesis and characterization of bis-diethylaminopropionamido derivatives. ARCHIV DER PHARMAZIE, vol. 321, p. 513-515, ISSN: 1521-4184

202

1988

Articolo in rivista Palu' G., Valisena S., Bertoloni G., Cera C., Palumbo M. (1988). A further insight into the m of action of anthracycline antibiotics. MICROBIOLOGICA, vol. 11, p. 307-319, ISSN: 0391-5

203

1988

Articolo in rivista Palù G, Valisena S, Peracchi M, Palumbo M (1988). Do quinolones bind to DNA?. BIOCHE PHARMACOLOGY, vol. 37, p. 1887-1889, ISSN: 0006-2952

204

1987 Articolo in rivista Palumbo M, Palù G, Gia O, Ferrazzi E, Gastaldi S, Antonello C, Meloni GA. (1987). Bis-sub hydroxy-anthracenediones: DNA-binding and biological activity. ANTI-CANCER DRUG DES 1, p. 337-346, ISSN: 0266-9536

205

1987 Articolo in rivista Mannucci LL, Cosani S, Palumbo M (1987). Treatment of dry eyes in several immune disea new hypothesis on the role of hydrophilic corneal lenses. OPHTALMOLOGIE, vol. 1, p. 523-ISSN: 0989-3105

206

1987 Articolo in rivista O. Gia, G. Palù, M. Palumbo, C. Antonello, S. Marciani Magno (1987). Photoreaction of pso derivatives with structurally organized DNA. PHOTOCHEMISTRY AND PHOTOBIOLOGY, 87-92, ISSN: 0031-8655

207

1986 Articolo in rivista Terbojevich M, Cosani A, Palumbo M, Pregnolato F (1986). Structural properties of hyaluro moderately concentrated solutions.. CARBOHYDRATE RESEARCH, vol. 149, p. 269-272, I 0008-6215

208

1986 Articolo in rivista Palù G, Palumbo M, Antonello C, Meloni GA, Marciani-Magno S (1986). A search for potent antitumor agents: biological effects and DNA binding of a series of anthraquinone derivative MOLECULAR PHARMACOLOGY, vol. 29, p. 211-217, ISSN: 0026-895X

209

1986

Articolo in rivista Ferrazzi E., Palumbo M., Valisena S, Antonello C, Palù G (1986). Antitumor activity of new anthraquinone derivatives.. CHEMIOTERAPIA, vol. 5, p. 330-336, ISSN: 0392-906X

210

1986 Articolo in rivista Rodighiero P., Palumbo M., Magno S.M. (1986). Methyl derivatives of tetrahydrobenzo- and benzofurocoumarins, a new class of potential photoreagents toward DNA. JOURNAL OF HETEROCYCLIC CHEMISTRY, vol. 23, p. 1405-1410, ISSN: 0022-152X

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1986 Articolo in rivista M. Palumbo, P. Rodighiero, O. Gia, A. Guiotto, S. Marciani Magno (1986). Benzofurocouma monofunctional DNA-photobinding agents. PHOTOCHEMISTRY AND PHOTOBIOLOGY, v 1-4, ISSN: 0031-8655, doi: 10.1111/j.1751-1097.1986.tb03555.x

212

1986 Articolo in rivista Gia O., Baccichetti F., Pastorini G., Rodighiero P., Palumbo M. (1986). Photobiological and binding properties of 4,8-dimethyl-5'-carboxypsoralen amides. MÉDECINE. BIOLOGIE. ENVIRONNEMENT, vol. 14, p. 115-119, ISSN: 0302-0800

213

1985 Articolo in rivista Palumbo M., Capasso L, Palu' G., Magno S.M. (1985). Conformational aspects of drug-DN interactions: Studies on anthracycline antibiotics and psoralen derivatives. JOURNAL OF BIOSCIENCES, vol. 8, p. 689-697, ISSN: 0250-5991

214

1985 Articolo in rivista Yevdokimov Y.M., Salianov V.I., Akimenko N.M., Chel'tsov P.A., Palumbo M. (1985). "Exter chromophores" and intense bands in the spectra of circular dichroism of the liquid crystallin microphases of nucleic acids. BIOPHYSICS, vol. 30, p. 1030-1038, ISSN: 0360-019X

215

1985 Articolo in rivista Evdokimov IuM, Salianov VI, Akimenko NM, Chel'tsov PA, Palumbo M (1985). "External chromophores" and intensive bands in circular dichroism spectra of liquid-crystalline microp nucleic acids. BIOFIZIKA, vol. 30, p. 948-954, ISSN: 0006-3029

216

1985 Articolo in rivista Yevdokimov Y., M., salyanov V.I., Poletaev A.I., Palumbo M. (1985). Liquid-crystalline state complexes with some biologically active compounds. DOKLADY BIOCHEMISTRY AND BIOPHYSICS, vol. VOL. 280-282, p. 14-17, ISSN: 1607-6729

217

1985

Articolo in rivista Mannucci LL, Moro F, Cosani A, Palumbo M (1985). Conformational state of lacrimal protei adsorbed on contact lenses.. CURRENT EYE RESEARCH, vol. 4, p. 734-736, ISSN: 0271-

218

1985 Articolo in rivista Bacchichetti F, Antonello C, Carlassare F, Gia O, Palumbo M, Bordin F (1985). Photobiologi properties of some water-soluble 5-MOP and 8-MOP derivatives.. PHOTODERMATOLOGY p. 221-228, ISSN: 0108-9684

219

1985 Articolo in rivista Evdokimov IuM, Salianov VI, Poletaev AI, Palumbo M (1985). [Liquid-crystal state of comple DNA with biologically active compounds].. DOKLADY AKADEMII NAUK SSSR, vol. 280, p. 1456-1459, ISSN: 0002-3264

220

1985 Articolo in rivista Evdokimov Y.M., Salyanov V., Palumbo M. (1985). Liquid chrystalline state of DNA molecul complexed with biologically active compounds . MOLECULAR CRYSTALS AND LIQUID C vol. 131, p. 285-297, ISSN: 0026-8941

221

1984

Articolo in rivista Palumbo M., Antonello S., Bonali F., Magno S.M. (1984). Interaction of deoxyribonucleic aci potential photobiological agents: A physicochemical investigation. INTERNATIONAL JOUR BIOLOGICAL MACROMOLECULES, vol. 6, p. 203-210, ISSN: 0141-8130, doi: 10.1016/0141-8130(84)90032-1

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1984

Articolo in rivista Palumbo M., Magno S.M. (1984). Studies on anthracycline antibiotics and related compoun interacting with DNA. STUDIA BIOPHYSICA, vol. 104, p. 123-130, ISSN: 0081-6337

223

1984 Articolo in rivista Palù G, Palumbo M, Cusinato R, Meloni GA, Marciani Magno S (1984). Antiviral properties psoralen derivatives: a biological and physico-chemical investigation.. BIOCHEMICAL PHARMACOLOGY, vol. 33, p. 3451-3456, ISSN: 0006-2952

224

1984 Articolo in rivista Peggion E, Mammi S, Palumbo M, Moroder L, Wünsch E (1984). Interaction of metal ions w gastrointestinal hormones: binding studies of Mg++ to biologically active analogs of little gas minigastrin.. BIOPOLYMERS, vol. 23, p. 1225-1240, ISSN: 0006-3525, doi: 10.1002/bip.36

225

1984 Articolo in rivista Palumbo M, Capasso L, Palù G, Marciani Magno S (1984). DNA-binding of water-soluble furocoumarins: a thermodynamic and conformational approach to understanding different bi effects.. NUCLEIC ACIDS RESEARCH, vol. 12, p. 8567-8578, ISSN: 0305-1048

226

1984 Articolo in rivista Palù G, Palumbo M, Cusinato R, Antonello C, Gastaldi S, Marciani Magno S, Meloni GA (19 Attività antivirale di Furocumarine [Antiviral activity of furocoumarins].. GIORNALE ITALIAN CHEMIOTERAPIA, vol. 31, p. 49-54, ISSN: 0017-0445

227

1983 Articolo in rivista Viano I., Palumbo M., Santiano M. (1983). In vitro antiviral activity and interaction with nucle of a benzodifuran derivative. DRUGS UNDER EXPERIMENTAL AND CLINICAL RESEARC p. 827-836, ISSN: 0378-6501

228

1983 Articolo in rivista Peggion E, Mammi S, Palumbo M (1983). Interaction of calcium ions with peptide hormones gastrin family.. BIOPOLYMERS, vol. 22, p. 2443-2457, ISSN: 0006-3525, doi: 10.1002/bip.360221110

229

1983 Articolo in rivista Palumbo M, Antonello C, Viano I, Santiano M, Gia O, Gastaldi S, Magno SM (1983). New anthracenedione derivatives: interaction with DNA and biological effects.. CHEMICO-BIOLO INTERACTIONS, vol. 44, p. 207-218, ISSN: 0009-2797

230

1983 Articolo in rivista Palumbo M., Magno S.M. (1983). Interaction of deoxyribonucleic acid with anthracenedione derivatives. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, vol. 5, p 301-307, ISSN: 0141-8130, doi: 10.1016/0141-8130(83)90046-6

231

1982 Articolo in rivista Cosani A., Terbojevich M., Palumbo M., Peggion E., Goodman M. (1982). N-Substituted pol acids. III. Synthesis and conformational properties of poly(N-methyl-L-glutamic acid) . BIOPOLYMERS, vol. 21, p. 471-474, ISSN: 0006-3525

232

1981 Articolo in rivista Palumbo M., Cosani A., Terbojevich M., Peggion E. (1981). Conformational studies on synt polypeptides: poly (d-phenylglycine) and poly(d-cyclohexylglycine). INTERNATIONAL JOU BIOLOGICAL MACROMOLECULES, vol. 3, p. 91-96, ISSN: 0141-8130

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233

1981 Articolo in rivista Jaeger E., Palumbo M., Peggion E., Wuensch E. (1981). Correlation between Ca2+ binding conformation and action of the gastrins. HEPATO-GASTROENTEROLOGY, vol. 28, p. 64-6 0172-6390

234

1981 Articolo in rivista Terbojevich M., Palumbo M., Cosani A., Peggion E., Gotte L., Garbisa S (1981). Interaction calcium ions with -elastin: an equilibrium dialysis, circular dichroism, and microcalorimetric s BIOPOLYMERS, vol. 20, p. 2213-2223, ISSN: 0006-3525

235

1981 Articolo in rivista Antonello C, Marciani Magno S, Gia O, Baessato O, Palumbo M (1981). 3-Amino- and 3-oxy-derivatives of psoralen: preparation and interactions with DNA.. IL FARMACO. EDIZI SCIENTIFICA, vol. 36, p. 629-647, ISSN: 0430-0920

236

1981

Articolo in rivista Magno S.M., Antonello C., Palumbo M. (1981). Interaction of 3-substituted psoralen derivati DNA. MÉDECINE. BIOLOGIE. ENVIRONNEMENT, vol. 9, p. 321-334, ISSN: 0302-0800

237

1981 Articolo in rivista Wünsch E, Jaeger E, Moroder L, Peggion E, Palumbo M (1981). Somatostatin-28: a confor analysis.. BIOPOLYMERS, vol. 20, p. 1741-1745, ISSN: 0006-3525, doi: 10.1002/bip.1981.360200813

238

1980 Articolo in rivista Palumbo M, Jaeger E, Knof S, Peggion E, Wünsch E (1980). Interaction of metal ions with gastrointestinal hormones. Binding of Ca2+ to Nle11-minigastrin I.. FEBS LETTERS, vol. 11 158-160, ISSN: 0014-5793

239

1980

Articolo in rivista Chessa G, Filippi B, Borin G, Moroder L, Palumbo M, Marchiori F (1980). Inhibition of the cy c/cytochrome c oxidase system by cytochrome c derivatives and related fragments.. HOPPE-SEYLER'S ZEITSCHRIFT FÜR PHYSIOLOGISCHE CHEMIE, vol. 361, p. 1077-10 0018-4888

240

1979 Articolo in rivista Cosani A., Terbojevich M., Palumbo M., Peggion E., Goodman M. (1979). N-substituted pol acids). 2. Conformational properties of poly(-ethyl N-methyl-L-glutamate) in various solvent MACROMOLECULES, vol. 12, p. 875-877, ISSN: 0024-9297

241

1979

Articolo in rivista Bonora G.M., Palumbo M., Toniolo C., Mutter M. (1979). Linear oligopeptides 55. Infrared conformational analysis of polyethylene glycol bound alanine and valine homooligopeptides solid state and in solution. DIE MAKROMOLEKULARE CHEMIE, vol. 180, p. 1293-1304, IS 0025-116X

242

1979

Articolo in rivista Palumbo M., Cosani A., Terbojevich M., Peggion E. (1979). Interaction of polypeptides with ions. POLYMER SCIENCE, vol. 21, p. 3040-3045, ISSN: 0965-545X

243

1978 Articolo in rivista Cosani A., Palumbo M., Terbojevich M., Peggion E. (1978). N-methyl poly(-amino acids). Sy and preliminary conformational analysis of poly(N-methyl--Methyl-L-glutamate). BIOPOLYM 17, p. 2519-2521, ISSN: 1097-0282

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n

244

1978 Articolo in rivista palumbo M., Cosani A., Terbojevich M., Peggion E. (1978). Metal complexes of poly-alpha-aminoacids. Interaction of copper(II) ions with poly(L-lysine) in the beta structure. BIOPOLYMERS, vol. 17, p. 243-246, ISSN: 1097-0282

245

1978 Articolo in rivista Cosani A., Palumbo M., Terbojevich M., Peggion E. (1978). N-Substituted poly(alpha-amino Synthesis and characterization of poly(N-methyl--methyl L-glutamate) and poly(N-methyl--et L-glutamate). MACROMOLECULES, vol. 11, p. 1041-1045, ISSN: 0024-9297

246

1978 Articolo in rivista Palumbo M., Cosani A., Terbojevich M., Peggion E. (1978). Metal complexes of poly(-amino Conformational aspects of the interaction between cupric ions and poly(L-histidine). MACROMOLECULES, vol. 11, p. 1271-1275, ISSN: 0024-9297

247

1978 Articolo in rivista Toniolo C., Bonora G.M., Palumbo M. (1978). Linear oligopeptides. XLIII. Study of the relati between conformation and nature of side chain: Homologous series derived from -branched acid residues. BIOPOLYMERS, vol. 17, p. 1713-1727, ISSN: 1097-0282

248

1978 Articolo in rivista Palumbo M., Cosani A., Terbojevich M., Peggion E. (1978). Metal complexes of poly(-amino Cu(II) chelates of acetoacetylated poly(L-lysine), poly(L-ornithine), and poly(L-diaminobutyri BIOPOLYMERS, vol. 17, p. 1003-1014, ISSN: 1097-0282

249

1977

Articolo in rivista Palumbo M, Cosani A, Terbojevich M, Peggion E (1977). Metal complexes of poly(alpha-am acids). A potentiometric and circular dichroism investigation of Cu(II) complexes of poly(L-ly poly(L-ornithine), and poly(L-diaminobutyric acid).. MACROMOLECULES, vol. 10, p. 813-82 0024-9297

250

1977

Articolo in rivista Palumbo M, Cosani A, Terbojevich M, Peggion E (1977). Metal complexes of poly(alpha-am acids). Optical rotatory properties of copper(II) complexes of poly-L-lysine, poly-L-ornithine, poly-L-diaminobutyric acid.. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 99, 939-941, ISSN: 0002-7863

251

1977 Articolo in rivista Benedetti E, Pavone V, Toniolo C, Bonora GM, Palumbo M (1977). Solid-state and solution conformation of N-tert-butyloxycarbonyl-L-prolylglycine.. MACROMOLECULES, vol. 10, p. 1350-1356, ISSN: 0024-9297

252

1977

Articolo in rivista Palumbo M, Cosani A, Terbojevich M, Peggion E (1977). Intermolecular indole-imidazolium complexes. II. Interaction of a block copolymer (L-tryptophan)n-(gamma-ethyl-DL-glutamate imidazolium hydrochloride and poly(L-histidine hydrochloride).. BIOPOLYMERS, vol. 16, p. ISSN: 0006-3525, doi: 10.1002/bip.1977.360160109

253

1977

Articolo in rivista Toniolo C, Palumbo M (1977). Solid-state infrared absorption spectra and chain arrangeme synthetic homooligopeptides in the intermolecularly hydrogen-bonded pleated-sheet beta-conformation.. BIOPOLYMERS, vol. 16, p. 219-224, ISSN: 0006-3525, doi: 10.1002/bip.1977.360160116

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5

254

1976

Articolo in rivista Palumbo M., Cosani A, Terbojevich M, Peggion E (1976). Ferric complexes of acetoacetyl d of poly(L-lysine), poly(L-ornithine), and poly(L-diaminobutyric acid). II. Conformational prope solution. Evidence for a stereospecific complex formation.. BIOPOLYMERS, vol. 15, p. 225 ISSN: 0006-3525, doi: 10.1002/bip.1976.360151112

255

1976 Articolo in rivista Palumbo M., Da Rin S., Bonora G.M., Toniolo C. (1976). Linear oligopeptides 29. Infrared conformational analysis of homo-oligopeptides in the solid state and in solution. DIE MAKROMOLEKULARE CHEMIE, vol. 177, p. 1477-1492, ISSN: 0025-116X

256

1976 Articolo in rivista Benedetti E, Palumbo M, Bonora GM, Toniolo C (1976). On the oxy analogues to the 4 lead intramolecularly hydrogen-bonded peptide conformations.. MACROMOLECULES, vol. 9, p. ISSN: 0024-9297

257

1976

Articolo in rivista Palumbo M, Cosani A, Terbojevich M, Bacchion G, Peggion E (1976). Ferric complexes of acetoacetyl derivatives of poly(L-lysine), poly(L-ornithine), and poly(L-diaminobutyric acid). I Preparation and absorption properties in solution.. BIOPOLYMERS, vol. 15, p. 2241-2253, I 0006-3525, doi: 10.1002/bip.1976.360151111

258

1976 Articolo in rivista Del Pra A, Palumbo M., Goodman M (1976). An X-ray study of poly(L-prolyl-L-alpha-phenylglycyl-L-proline).. BIOPOLYMERS, vol. 15, p. 503-506, ISSN: 0006-3525, doi: 10.1002/bip.1976.360150306

259

1976 Articolo in rivista Peggion E, Cosani A, Palumbo M, Terbojevich M (1976). A potentiometric and CD investiga the conformational properties of poly(L-p-aminophenylalanine) in aqueous solution.. BIOPO vol. 15, p. 2227-2239, ISSN: 0006-3525, doi: 10.1002/bip.1976.360151110

260

1976 Articolo in rivista Toniolo C, Palumbo M, Benedetti E (1976). On the oxy analogues to the 3 leads to 1 intram hydrogen-bonded peptide conformations.. MACROMOLECULES, vol. 9, p. 420-424, ISSN: 0024-9297

261

1975 Articolo in rivista Palumbo M., Rodin RL, Goodman M (1975). Synthesis and conformational studies in solutio sequential copolypeptides: poly(L-prolyl-L-alpha-phenylglycyl-L-proline).. BIOCHEMISTRY, 485-491, ISSN: 0006-2960

262

1975

Articolo in rivista Shibaev V, Palumbo M, Peggion E (1975). Synthesis and conformational properties of polyp containing long aliphatic side chains. Poly(N-epsilon-stearyl-L-lysine) and poly(N-epsilon-pelargonyl-L-lysine).. BIOPOLYMERS, vol. 14, p. 73-81, ISSN: 0006-3525, d 10.1002/bip.1975.360140106

263

1975 Articolo in rivista Palumbo M, Peggion E (1975). Letter: Optical activity of the charge-transfer complex betwe poly-L-histidine hydrochloride and indole.. BIOPOLYMERS, vol. 14, p. 431-432, ISSN: 0006 doi: 10.1002/bip.1975.360140215

264

1974

Articolo in rivista Peggion E., Palumbo M., Bonora G.M., Toniolo C. (1974). Phenylalanine oligopeptides: circ dichroism studies in solution. BIOORGANIC CHEMISTRY, vol. 3, p. 125-132, ISSN: 0045-2

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a T

265

1974 Articolo in rivista Goodman M. Gilon C., Palumbo M., Ingwall R. (1974). Polydepsipeptides II. Synthesis and preliminary conformational studies of an alternating alpha-amino and alpha-hydroxy acid pol ISRAEL JOURNAL OF CHEMISTRY, vol. 12, p. 67-77, ISSN: 0021-2148

266

1974 Articolo in rivista Cosani A, Palumbo M, Terbojevich M, Peggion E (1974). A potentiometric and CD study on beta-random coil transition of poly-L-tyrosine in aqueous solution.. INTERNATIONAL JOUR PEPTIDE & PROTEIN RESEARCH, vol. 6, p. 457-463, ISSN: 0367-8377

267

1974 Articolo in rivista Goodman M., Steinfeld A., Tonelli A., Lepore U., Palumbo M., Donzel B. (1974). Synthesis conformational analysis of cyclo-TRI[l-valyl-d-hexahydromandelyl]. BIOORGANIC CHEMIS 3, p. 184-203, ISSN: 0045-2068

268

1973

Articolo in rivista Cosani, A., Terbojevich, M., Palumbo, M., Peggion, E., Scoffone, E (1973). Solution properti synthetic polypeptides. Synthesis and conformational properties of poly(N-acetoacetyl-L-lysi poly(N-acetoacetyl-L-ornithine), and poly(N-acetoacetyl-L-diaminobutyric acid) in aqueous s MACROMOLECULES, vol. 6, p. 571-577, ISSN: 0024-9297

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Direzione di enti o istituti di ricerca di alta qualificazione internazionale

Direttore del Dipartimento di Scienze Farmaceutiche- Università di Padova dal 01-10-2001 al 30-09-2005 Direttore del Dipartimento di Scienze del Farmaco - Università di Padova dal 01-01-2012 al 30-09-2015

Responsabilità scientifica per progetti di ricerca internazionali e nazionali, ammessi al finanziamento sulla base di bandi competitivi che prevedano la revisione tra pari

Piano Nazionale Farmaci 1997-2000 MIUR - Responsabile Unità Operativa dal 01-01-1997 al 31-12-2000 Ricerca Sanitaria Finalizzata- Regione Veneto 1997 - Responsabile del Progetto dal 01-01-1998 al 31-12-1999 FP5-2000 Human Potential Responsabile Unità Operativa dal 01-01-2001 al 31-12-2004 PRIN 2000 -Responsabile Unità Operativa dal 01-01-2001 al 31-12-2003 FIRB Progetti Autonomi 2001 dal 01-01-2002 al 31-12-2005 PRIN 2001 Responsabile Unità Operativa dal 01-01-2002 al 31-12-2003 PRIN 2002 Responsabile Unità Operativa dal 01-01-2003 al 31-12-2004 FP6-2002 LIFESCIHEALTH Responsabile Unità Operativa dal 01-01-2003 al 31-12-2006 PRIN 2003 Responsabile Unità Operativa dal 01-01-2004 al 31-12-2005 AIRC Principal Investigator dal 01-01-2008 al 31-12-2010 PRIN 2010-2011 Responsabile Unità Operativa dal 01-01-2012 al 31-12-2015 Progetto Ricerca Interarea - Universtà di Padova Principal Investigator dal 01-01-2012 al 31-12-2013

Direzione o partecipazione a comitati editoriali di riviste, collane editoriali, enciclopedie e trattati di riconosciuto prestigio

Current Medicinal Chemistry- Anticancer Agents dal 01-05-2001 al 30-04-2010 Medicinal Chemistry Reviews dal 01-01-2004 al 31-12-2005

Incarichi di insegnamento o di ricerca (fellowship) presso qualificati atenei e istituti di ricerca esteri o sovranazionali

Titoli

Research Chemist, University of California San Diego dal 01-01-1972 al 31-07-1973 NATO Fellowship - University of California San Diego dal 01-06-1979 al 30-09-1979 Reasearch Associate Max Planck Institut fuer Biochemie - Monaco di Baviera dal 01-05-1980 al 30-04-1981 Visiting Professor Universidad de Santiago de Compostela dal 01-03-1997 al 31-07-1997

Premi e riconoscimenti per l’attività scientifica, inclusa l’affiliazione ad accademie di riconosciuto prestigio nel settore

Medaglia "Giacomello" della Divisione di Chimica Farmaceutica della Società Chimica Italiana dal 09-09-2015 al 09-09-2015

Nei settori concorsuali in cui è appropriato, risultati ottenuti nel trasferimento tecnologico in termini di partecipazione alla creazione di nuove imprese (spin off), sviluppo, impiego e commercializzazione di brevetti

Coautore di 4 brevetti internazionali dal 01-01-1992 a oggi

Altri titoli che contribuiscano a una migliore definizione del profilo scientifico

Fa parte - degli esperti dell'INSERM e INCA(Francia), - degli esperti generali della Commissione Europea. E' valutatore di progetti -PRIN, FIRB, Futuro in ricerca e SIR (MIUR), - Human Science Frontiers (Francia), - Israel Science Foundation (Israele), - International Center for Genetic Engineering and Biotechnology (Trieste), - Czech Science Foundation (Repubblica Ceca). E' stato - per 6 anni Presidente dell'area scientifica "Scienze del Farmaco"- Università di Padova - per 4 anni in commissione di Ateneo per i rapporti culturali con l'estero -Università di Padova