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Allegato 2 Schema della struttura del gene TRP53 Legenda: 5' downstrea m sequence Exon ..........gggggttgctgggattgggactttcccctcccacgtgctcaccctgg cta Lunghezza(nt) 1 128 AAGTTCTGTAGCTTCAGTTCATTGGGACCATCCTGGCTGTAGGTAGCGACTACAGTTAG G GGGCACCTAGCATTCAGGCCCTCATCCTCCTCC TTCCCAGCAGGGTGTCACGCTTCTCC G AAGACTGG Intron 1-2 6,3 75 gtaagtaattgatgagcgtgacgagacctctcggtcactggctctctccgtttgcatcc a taaaactagagaaaaccgtggggtttgggggtggggcagt................... . ....................attctaccctttcctataagccataggggtttgtttgtt t gta tgttttttaattgacaagttatgcatccatacagtacacaa tctcttctctctaca g 2 83 ATGACTGCCATGGAGGAGTCACAGTCGGATATCAGCCTCGAGCTCCCTCTGAGCCAGGA G ACATTTTCAGGCTTATGGAAACT Intron 2-3 283 gtgagtggatctttttggggcccttaagatacatcccgccatacctgtatcctcccctt g cctgagagaaacaaaaacagtagtgttcaaacatggtatg................... . ....................tgactacatagcaagttggaggccagcctgggataagtg a gattctgtcttcaaaaaatggaaggaaatcaggaactaactctctgctcttg ttttcca g USR – IFOM – ANSAS “LO STUDENTE RICERCATORE - Anno 2010 – Relazione finale scientifica dello studente Struttura del gene Trp53 ( Mus Musculus ) Regione intronica Regione esonica tradotta Regione esonica non tradotta

Transcript of Allegato 2

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Allegato 2

Schema della struttura del gene TRP53

Legenda:

5' downstream sequenceExon

..........gggggttgctgggattgggactttcccctcccacgtgctcaccctggcta

Lunghezza(nt)

1 128 AAGTTCTGTAGCTTCAGTTCATTGGGACCATCCTGGCTGTAGGTAGCGACTACAGTTAGGGGGCACCTAGCATTCAGGCCCTCATCCTCCTCCTTCCCAGCAGGGTGTCACGCTTCTCCGAAGACTGG

  Intron 1-2

6,375

gtaagtaattgatgagcgtgacgagacctctcggtcactggctctctccgtttgcatccataaaactagagaaaaccgtggggtttgggggtggggcagt........................................attctaccctttcctataagccataggggtttgtttgtttgtatgttttttaattgacaagttatgcatccatacagtacacaatctcttctctctacag

2 83 ATGACTGCCATGGAGGAGTCACAGTCGGATATCAGCCTCGAGCTCCCTCTGAGCCAGGAGACATTTTCAGGCTTATGGAAACT

  Intron 2-3

283 gtgagtggatctttttggggcccttaagatacatcccgccatacctgtatcctccccttgcctgagagaaacaaaaacagtagtgttcaaacatggtatg........................................tgactacatagcaagttggaggccagcctgggataagtgagattctgtcttcaaaaaatggaaggaaatcaggaactaactctctgctcttgttttccag

3 22 ACTTCCTCCAGAAGATATCCTG  Intron

3-493 gtaaggcccagagcagaaagggacttgggctttggtgttgggtggtaggctgagaacac

agtcctgagggttcttctttgtcccatccacag4 261 CCATCACCTCACTGCATGGACGATCTGTTGCTGCCCCAGGATGTTGAGGAGTTTTTTGA

AGGCCCAAGTGAAGCCCTCCGAGTGTCAGGAGCTCCTGCAGCACAGGACCCTGTCACCGAGACCCCTGGGCCAGTGGCCCCTGCCCCAGCCACTCCATGGCCCCTGTCATCTTTTGTCCCTTCTCAAAAAACTTACCAGGGCAACTATGGCTTCCACCTGGGCTTCCTGCAGTCTGGGACAGCCAAGTCTGTTATGTGCACG

USR – IFOM – ANSAS“LO STUDENTE RICERCATORE - Anno 2010 – Relazione finale scientifica dello studente

Struttura del gene Trp53 ( Mus Musculus )

Regione intronica

Regione esonica tradotta

Regione esonica non tradotta

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  Intron 4-5

731 gtgagtgggccccggggagttgtctttcgtgtgacctttcaatgcctctttttctctgtctagatttgggggttcctcttcagcctgtagactgtgcctc........................................tccaatggtgcttggacaatgtgtttcattagttccccaccttgacacctgatcgttactcggcttgtccccgacctccgttctctctcctctcttccag

5 184 TACTCTCCTCCCCTCAATAAGCTATTCTGCCAGCTGGCGAAGACGTGCCCTGTGCAGTTGTGGGTCAGCGCCACACCTCCAGCTGGGAGCCGTGTCCGCGCCATGGCCATCTACAAGAAGTCACAGCACATGACGGAGGTCGTGAGACGCTGCCCCCACCATGAGCGCTGCTCCGATGGTGATG

  Intron 5-6

78 gtaagccctcaacaccgcctgtggggttaggactggcagcctcccatctcccggcttctgacttattcttgctcttag

6 113 GCCTGGCTCCTCCCCAGCATCTTATCCGGGTGGAAGGAAATTTGTATCCCGAGTATCTGGAAGACAGGCAGACTTTTCGCCACAGCGTGGTGGTACCTTATGAGCCACCCGAG

  Intron 6-7

402 gtctgtaattttgttttggtttgtgcgtcttagagacagttgactccagcctagactgatgttgactttctagcaacccgtttgcctcaccctcctgagt........................................tgaaacttattagaggctatagccagccattcccggctgctgcaggtcacctgtagtgaggtagggagcgacttcacctggatcctgtgtcttcccccag

7 110 GCCGGCTCTGAGTATACCACCATCCACTACAAGTACATGTGTAATAGCTCCTGCATGGGGGGCATGAACCGCCGACCTATCCTTACCATCATCACACTGGAAGACTCCAG

  Intron 7-8

322 gtaggaaggcgcgtggtaggttaggttagcctgtttcttccccagcttctgcctgtttctgttccacgagtcccgccccctaccacatgcccaacgctct........................................aagaggggttgggaacaggtgggggcctagtttacacacagtcaggatggggcccagctttcttactgccttgtgctggtccttttcttgtcccggatag

8 137 TGGGAACCTTCTGGGACGGGACAGCTTTGAGGTTCGTGTTTGTGCCTGCCCTGGGAGAGACCGCCGTACAGAAGAAGAAAATTTCCGCAAAAAGGAAGTCCTTTGCCCTGAACTGCCCCCAGGGAGCGCAAAGAGAG

  Intron 8-9

79 gtacgcaggcgggaccaaggaggcggaggagcctgttgagcttcaccccaaagtcacctcttgctctctccttccacag

9 74 CGCTGCCCACCTGCACAAGCGCCTCTCCCCCGCAAAAGAAAAAACCACTTGATGGAGAGTATTTCACCCTCAAG

  Intron 9-10

793 gtaccaaggctggagagtcgcatgccagagacaagctgtacccattattgcctctgtctctcgcatgtataaaatagtgttattagcaggttgccaggtc........................................ttaagttgggaaccaactttcagaaagaaagttgttaaaatcgtgaaagtggttgtgtgaccttgtccagtgcttccatctcacttcatctctgctgcag

10 107 ATCCGCGGGCGTAAACGCTTCGAGATGTTCCGGGAGCTGAATGAGGCCTTAGAGTTAAAGGATGCCCATGCTACAGAGGAGTCTGGAGACAGCAGGGCTCACTCCAG

  Intron 10-11

587 gtaagtggcctggggcagcgcctgcctgtggtgctctacccagacctccctccagctcagcctttgtagtgaaagataaaaaccccaccctgctagatgc........................................tcagcctccagcctagagccttccaagccttgatcaagga

USR – IFOM – ANSAS“LO STUDENTE RICERCATORE - Anno 2010 – Relazione finale scientifica dello studente

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ggaaagcccaaactgctagctcccatcacttcatccctccccttttctgtcttcctatag

11 523 CTACCTGAAGACCAAGAAGGGCCAGTCTACTTCCCGCCATAAAAAAACAATGGTCAAGAAAGTGGGGCCTGACTCAGACTGACTGCCTCTGCATCCCGTCCCCATCACCAGCCTCCCCCTCTCCTTGCTGTCTTATGACTTCAGGGCTGAGACACAATCCTCCCGGTCCCTTCTGCTGCCTTTTTTACCTTGTAGCTAGGGCTCAGCCCCCTCTCTGAGTAGTGGTTCCTGGCCCAAGTTGGGGAATAGGTTGATAGTTGTCAGGTCTCTGCTGGCCCAGCGAAATTCTATCCAGCCAGTTGTTGGACCCTGGCACCTACAATGAAATCTCACCCTACCCCACACCCTGTAAGATTCTATCTTGGGCCCTCATAGGGTCCATATCCTCCAGGGCCTACTTTCCTTCCATTCTGCAAAGCCTGTCTGCATTTATCCACCCCCCACCCTGTCTCCCTCTTTTTTTTTTTTTTACCCCTTTTTATATATCAATTTCCTATTTTACAATAAAATTTTGTTATCACTT

3' downstream sequence

atatggttttgagaggttgatatcagcataagctgtctgggcccccaggg..........

USR – IFOM – ANSAS“LO STUDENTE RICERCATORE - Anno 2010 – Relazione finale scientifica dello studente

Le sequenze in minuscolo verde corrispondono alle regioni non tradotte alle estremità del gene (UTRs)Le sequenze in minuscolo blu corrispondono alle regioni introniche situate tra gli esoniLe sequenze in maiuscolo nero corrispondono alle regioni esoniche tradotteLe sequenze in maiuscolo viola corrispondono alle regioni esoniche non tradotte

La sequenza codificante inizia con lo start codon ATG (Met) e termina con lo stop codon TGA