Cari colleghi,In vista del rinnovo delle cariche riservate ai soci SIEDP nell’ambito della rivista

"Journal of Endocrinological Investigation", vorrei proporre la mia candidatura a Reviewing Editor. Sarò onorata di una vostra eventuale preferenza.

È possibile segnalare 1 nome per Editor e Associate Editor e fino a 3 nomi per i Reviewing Editors del JEI. Se ritenete di sostenere la mia candidatura, vi invito a indicare il mio nominativo entro il 5 luglio p.v., compilando la sezione apposita della scheda scaricabile dalla corrispondente pagina del portale della Società. Allego CV.

Grazie.Cordiali salutiAlessandra Vottero

Curriculum vitae

Nome: Alessandra Vottero

Indirizzo: via I. Pizzi 343100 Parmatel: 0521-968659cell. 348-9154981

Data di nascita: 19 maggio 1963

Luogo di nascita Pisa

Stato civile: Sposata

Istruzione pre- ed universitaria:

1976-1982 Maturità Scientifica,Liceo Scientifico, Parma

1983-1992 Laurea in Medicina e Chirurgia, Università degli Studi di Milano (106/110)

1992-1996 Specializzazione in PediatriaUniversità degli Studi di Parma(50/50 cum laude)

2000-2003 Dottorato di Ricerca in Gastro-Endocrinologia PediatricaUniversità degli Studi di Parma

2002-2003 Master di II livelli in “Management dei disordini endocrini, metabolico e alimentari dell’età evolutiva”Università degli Studi di Parma(110/110 cum laude)

Abilitazione: 1992 Abilitazione all'esercizio della professione medica

Specializzazioni e stages all’estero:

1992-1996 Specializzazione in Pediatria Generale

Università degli Studi di Parma(50/50 cum laude)

Novembre 1995-1997:Research FellowshipSection on Pediatric Endocrinology (Dir Dr. G.P. Chrousos)Developm. Endocrinology Branch, NICHDNational Institutes of Health Bethesda, Md 20892(Research Fellowship Sponsorizzata da Novo Nordisk a/s)

Novembre 1997-2000:Visiting FellowshipSection on Pediatric Endocrinology (Dir Dr. G.P. Chrousos)Developm. Endocrinology Branch, NICHDNational Institutes of Health Bethesda, Md 20892(Fogarty Visiting Fellowship Award)

2002-2003 Master Universitario di II livello in“Management dei disordini endocrini, metabolici e alimentari dell’età evolutiva” Università degli Studi di Parma

2003-2007 Assegno di ricerca in Endocrinologia PediatricaClinica Pediatrica Dipartimento dell’età evolutiva (Dir. Prof. S. Bernasconi)Università di Parma

Titolare di Borsa di studio in Endocrinologia Pediatrica(dal gennaio 2007 al gennaio 2008)Clinica Pediatrica Dipartimento dell’età evolutiva (Dir. Prof. S. Bernasconi)Università di Parma

Posizione attuale: Contratto a tempo determinato(da marzo 2008 ad adesso)Clinica Pediatrica Dipartimento dell’età evolutiva (Dir. Prof. S. Bernasconi)Università di Parma

Premi ed onoreficienze:

Società Italiana di Pediatria (SIP) 1997 Research Award

Società Italiana di Diabetologia e Endocrinologia Pediatrica (SIEDP) 1999 Borsa di Studio sulla Pubertà Precoce

Endocrine Society (ES) 1999 Travel Award

Endocrine Society (ES) 1999 International Award for Excellence in Published Clinical Research:The Aromatase Excess Syndrome Is Associated With Feminization Of Both Sexes And Autosomal Dominant Transmission Of Aberrant P450arom Gene Transcription. C.A Stratakis, A. Vottero, A. Brodie, L.S. Kirschner, D. DeAtkine, Q. Lu, W. Yue, C.S. Mitsiades, A.W. Flor, G.P. Chrousos. J Clin Endocrinol Metab. 1998; 83 (4): 1348-1357.

European Society for Pediatric Endocrinology (ESPE) 1999 Travel Award

European Society for Pediatric Endocrinology (ESPE) 2000 Travel Award

European Society for Pediatric Endocrinology (ESPE) 2000 Henning Andersen Prize for the best basic science abstract

Società Italiana di Diabetologia e Endocrinologia Pediatrica (SIEDP) 2001 Borsa di Studio in Endocrinologia Pediatrica

Endocrine Society (ES) 2005 Travel Award

Endocrine Society (ES) 2007 Travel Award

Società Italiana di Diabetologia e Endocrinologia Pediatrica (SIEDP) 2007 Premio “Rina Balducci” per il miglior lavoro scientifico pubblicato negli ultimi 2 anni.

Corsi post-laurea : Growth Seminar.Organized by Kabi International Growth Study.Stockholm, 1-4 October 1992.

Knemometry.Organized by the Italian Society for Paediatric Endocrinology.Torino, 9-10 November 1992.

Post-graduate course on Paediatric Endocrinology.Organized by the Italian Society for Paediatric Endocrinology.Taormina, 10-12 December 1992.

Post-graduate course on Molecular Genetics for Endocrinology.Lerici, 9-10 December 1993

Post-graduate course on Molecular Biology for Endocrinology.Firenze, 31 March-1 April 1995

International Symposium on A current Review of Pediatric EndocrinologyWashington, DC, April 28-May 2, 1997

ESPE Summer School 1997June 18-22 1997Roslagens Pärla, Ljusterö, Sweden

International Symposium on A current Review of Pediatric EndocrinologyBethesda, MD, September 9-13, 1998

Società: Società di Medicina e Scienze Naturali

Società Italiana di Pediatria (SIP)

Società Italiana di Diabetologia ed Endocrinologia Pediatrica (SIEDP)

Endocrine Society (ES)

European Society for Pediatric Endocrinology (ESPE)

ARTICOLI ORIGINALI

1. Dynamics of 24-hour pulsatile cortisol, 17-hydroxyprogesterone, and androstenedione release in prepubertal patients with nonclassic 21-hydroxylase deficiency and normal prepubertal children. L. Ghizzoni, S. Bernasconi, R. Virdis, A. Vottero, M. Ziveri, C. Volta, L. Iughetti, G.Giovannelli. Metabolism. 1994; 43:372-377 (I.F. 2.013).

2. Premature pubarche: differential diagnosis, auxological features and clinical outcome. S. Bernasconi, L. Ghizzoni, A. Vottero, M. Zampolli, C. Volta, T. Onesti, M. Costa, R. Virdis. Zdrav Vestn. 1994; 63:I-33-35.

3. Isolated growth hormone deficiency type IA associated with a 45-kilobase gene deletion within the human growth hormone gene cluster in an Italian family. L. Ghizzoni, P. Duquesnoy, T. Torresani, A. Vottero, M. Goossens, S. Bernasconi. Pediatr Res. 1994; 36:654-659 (I.F. 3.064).

4. Spontaneous cortisol and growth hormone secretion interactions in patients with nonclassic 21-hydroxylase deficiency (NCCAH) and control children. L. Ghizzoni, G. Mastorakos, A. Vottero, M.A. Magiakou, G.P. Chrousos, S. Bernasconi. J Clin Endocrinol Metab. 1996; 81(2): 482-487 (I.F. 5.873).

5. Pituitary-ovarian responses to leuprolide acetate testing in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. L. Ghizzoni, R. Virdis, A. Vottero, M. Cappa, M.E. Street, M. Zampolli, L. Ibanez, S. Bernasconi. J Clin Endocrinol Metab. 1996; 81(2): 601-606 (I.F. 5.873).

6. Dose-dependent inhibition of growth hormone (GH)-releasing hormone-induced GH release by corticotropin-releasing hormone in prepubertal children. L. Ghizzoni, A. Vottero, M.E. Street, S. Bernasconi. J Clin Endocrinol Metab. 1996; 81(4): 1397-1400 (I.F. 5.873).

7. Dideoxyfingerprinting (ddF) analysis of the type X collagen gene (COL10A1) and identification of a novel mutation (S671P) in a kindred with Schmid metaphyseal chondrodysplasia. C.A. Stratakis, Z. Orban, A.L. Burns, A. Vottero, C.S. Mitsiades, S.J. Marx, V. Abbassi, G.P. Chrousos. Biochem Mol Med. 1996; 59: 112-117.

8. Corticotropin-releasing hormone (CRH) inhibits steroid biosynthesis by cultured human granulosa-lutein cells in a CRH and interleukin-1-receptor-mediated fashion. L. Ghizzoni, G. Mastorakos, A. Vottero, A. Barreca, M. Furlini, A. Cesarone, B. Ferrari, G.P. Chrousos, S. Bernasconi. Endocrinology 1997; 138 (11): 4806-4811 (I.F. 5.063).

9. Spontaneous thyrotropin and cortisol secretion interactions in patients with nonclassic 21-hydroxylase

deficiency and control children. L. Ghizzoni, G. Mastorakos, M.E. Street, A. Vottero, G. Mazzardo, M. Vanelli, G.P. Chrousos, S. Bernasconi. J Clin Endocrin Metab. 1997; 82 (11): 3677-3683 (I.F. 5.873).

10. Association of glucocorticoid insensitivity with increased expression of glucocorticoid receptor . D.Y.M. Leung, Q. Hamid, A. Vottero, S.J. Szefler, W. Surs, E. Minshall, G.P. Chrousos, D.J. Klemm. J Experim Med. 1997; 186 (9): 1567-1574 (I.F. 15.302)

11. The aromatase excess syndrome is associated with feminization of both sexes and autosomal dominant transmission of aberrant P450arom gene transcription. C.A Stratakis, A. Vottero, A. Brodie, L.S. Kirschner, D. DeAtkine, Q. Lu, W. Yue, C.S. Mitsiades, A.W. Flor, G.P. Chrousos. J Clin Endocrinol Metab. 1998; 83 (4): 1348-1357 (I.F. 5.873).

12. P450arom gene expression in peripheral blood lymphocytes: identification of a cryptic splice site for

exon-1 after Epstein-Barr virus transformation. A. Vottero, L.S. Kirschner, W. Yue, A. Brodie, C.A. Stratakis. J Steroid Biochem. 1998; 64 (5-6): 245-250 (I.F. 2.596).

13. Plasma cortisol responses after intramuscular ACTH 1-24 in healthy men. C.A. Longui, A. Vottero, A. Harris, G.P. Chrousos. Metabolism 1998; 47(11): 1419-1422 (I.F. 2.013).

14. Imbalanced expression of the glucocorticoid receptor isoforms in cultured lymphocytes from a patient with systemic glucocorticoid resistance and chronic lymphocytic leukemia. H. Shahidi, A. Vottero, C.A. Stratakis, S.E. Taymans, M. Karl, C.A. Longui, G.P. Chrousos, S.A. Daughaday, W.H. Gregory, J.M.D. Plate. Biochem Biophys Res Commun. 1999; 254(3): 559-565 (I.F. 2.836).

15. Androgen receptor-mediated hypersensitivity to androgens in women with nonhyperandrogenic hirsutism: skewing of X-chromosome inactivation. A. Vottero, C.A. Stratakis, L. Ghizzoni, C.A. Longui, M. Karl, G.P. Chrousos. J Clin Endocrinol Metab. 1999; 84(3): 1091-1095 (I.F. 5.873).

16. Low glucocorticoid receptor GRalpha/GRbeta ratio in T-cell lymphoblastic leukemia. C.A. Longui, A. Vottero, P.C. Adamson, D.E. Cole, T. Kino, O. Monte, G.P. Chrousos. Horm Metab Res. 2000; 32 (10):401-406 (I.F. 1.669).

17. Long-term results with growth hormone (GH) therapy in idiopathic hypopituitarism. S. Bernasconi, T.

Arrigo, M. Wasniewsk, L.Ghizzoni, C. Ruggeri, T. Di Pasquale, A. Vottero, F. De Luca. Horm. Res. 2000; 53 (suppl. 1):55-59(I.F. 1.669) .

18. High constitutive glucocorticoid receptor in human neutriphils enables them to reduce their spontaneous rate of cell death in response to glucocorticoids. I. Strickland, K. Kisich, P.J. Hauk, A. Vottero, G.P. Chrousos, D.J. Klemm, D.Y.M. Leung. J Experim Med. 2001; 193 (5):585-593 (I.F. 15.302).

19. Interactions of leptin and thyrotropin 24-hour secretory profiles in short-normal children. L. Ghizzoni, G. Mastorakos, M. Ziveri, M. Furlini, A. Solazzi, A. Vottero, S. Bernasconi. J Clin Endocrinol Metab. 2001; 86 (5): 2065-2072 (I.F. 5.873).

20. Leptin, cortisol, and GH secretion interactions in short normal prepubertal children. L. Ghizzoni, G. Mastorakos, M.E. Street, G. Mazzardo, A. Vottero, M. Vanelli, S. Bernasconi. J Clin Endocrinol Metab. 2001; 86 (8):3729-3734 (I.F. 5.873).

21. Leptin inhibits steroid biosynthesis by human granulosa-lutein cells. L. Ghizzoni, A. Barreca, G. Mastorakos, M. Furlini, A. Vottero, B. Ferrari, G.P. Chrousos, S. Bernasconi. Horm Metab Res. 2001; 33: 323-328 (I.F. 1.669).

22. A novel, C-terminal dominant negative mutation of the GR causing familial glucocorticoid resistance through abnormal interactions with p160 steroid receptor coactivators. A. Vottero, H. Combe, P. Lecomte, T. Kino, G.P. Chrousos. J Clin Endocrinol Metab. . J Clin Endocrinol Metab. 2002; 87 (6):2658-2667 (I.F. 5.873).

23. Increased glucocorticoid receptor beta expression converts mouse hybridoma cells to a corticoid resistant phenotype. P.A. Hauk, E. Goleva, I. Strickland, A. Vottero, G.P. Chrousos, K. Kisich, D.Y.M. Leung. Am J Respir Cell Mol Biol. 2002; 27:361-367 . (I.F. 4.015)

24. Familial/sporadic glucocorticoid resistance syndrome and hypertension. T. Kino, A. Vottero, E. Charmandari, G.P. Chrousos. Ann N Y Acad Sci 2002 2002; 970: 101-111 (I.F. 1.892).

25. Hormonal regulation of interleukin-6 production in human adipocytes. V. Vicennati, A. Vottero, C. Friedman, D.A. Papanicolaou. Int J Obes 2002; 26(7): 905-911 (I.F. 2.794)

26. Relative abundance of growth hormone receptor isoforms in Rhesus monkey tissues and human transformed lymphocytes. A. Vottero, C. Kimchi-Sarfaty, J. Kratzsch, G. Miller, A. Lafferty, G.P. Chrousos, Z. Hochberg. Horm Metab Res 2003; 35: 1-6 (I.F. 1.669).

27. Transcriptional and translational regulation of the splicing isoforms of the growth hormone receptor by glucocorticoids. A. Vottero, C. Kimchi-Sarfaty, J. Kratzsch, G.P. Chrousos, Z. Hochberg. Horm Metab Res 2003; 35: 7-12 (I.F. 1.669).

28. Natural glucocorticoid receptor mutants causing generalized glucocorticoid resistance: molecular genotype, genetic transmission, and clinical phenotype. E. Charmandari, T. Kino, E. Souvatzoglou, A. Vottero, N. Bhattacharyya, G.P. Chrousos. J Clin Endocrinol Metab. 2004; 89(4):1939-1949 (I.F. 5.873).

29. Spontaneous GH secretion is not directly affected by ghrelin either in short-normal prepubertal children or in children with GH neurosecretory dysfunction. L. Ghizzoni, G. Mastorakos, A. Vottero, M. Ziveri, I. Viani, S. Bernasconi. J Clin Endocrinol Metab. 2004; 89(11):5488-5495(I.F. 5.873) .

30. Physical activity and hypothalamic-pituitary-gonadal axis (HPG) function. S. Bernasconi, T. Luppino, M. Ferrari, V. Barone, A. Vottero. Minerva Pediatrica. 2004; 56(Suppl.1):25-27.

31. Novità in endocrinologia pediatrica. L. Ghizzoni, L. Iughetti, S. Madeo, G. Radetti, A. Vottero, S. Bernasconi. Prospettive in pediatria. 2004; 34:241-247.

32. The human glucocorticoid receptor (hGR) beta isoform suppresses the transcriptional activity of hGR alpha by interfering with formation of coactivator complexes. E. Charmandari, G.P. Chrousos, T. Ichijo, N. Bhattacharyya, A. Vottero, E. Souvatzoglou, T. Kino. Mol Endocrinol. 2005;19(1):52-64 (I.F. 5.708)

33. Aromatase is differentially expressed in peripheral blood leukocytes from children, and adult female and male subjects. A. Vottero, V. Rochira, M. Capelletti, I. Viani, L. Zirilli, T.M. Neri, C. Carani, S. Bernasconi, L. Ghizzoni. Eur J Endocrinol. 2006 ; 154 (3):425-31 (I.F. 52.941).

34. Decreased androgen receptor gene methylation in premature pubarche: a novel pathogenetic mechanism? A. Vottero, M. Capelletti, S. Giuliodori, I. Viani, M. Ziveri, T.M. Neri, S. Bernasconi, L. Ghizzoni. J Clin Endocrinol Metab. 2006; 91(3):968-972 (I.F. 5.873).

35. Final height in girls with central idiopathic precocious puberty treated with GnRH analogue and oxandrolone. A. Vottero, S. Pedori, M. Verna, B. Pagano, M. Cappa, L. Loche, S. Bernasconi, L. Ghizzoni. J Clin Endocrinol Metab. 2006; 91(4):1284-1287 (I.F. 5.873).

36. Clinical significance of the parental origin of the X chromosome in Turner syndrome. L. Sagi, N. Zucherman-Levin, A. Gawlik, L. Ghizzoni, A. Buyukgebiz, Y. Bistritzer, O. Admoni, A. Vottero, O. Baruch, F. Fares, E. Malecka-Tendera, Z. Hochberg. . J Clin Endocrinol Metab. 2007; 92(3):846-852 (I.F. 5.873).

37. Ghrelin inhibits steroids biosymthesis by cultured human granulosa-lutein cells. I. Viani, A. Vottero, F. Tassi, G. Cremonini, C. Sartori, S. Bernasconi, B. Ferrari, L. Ghizzoni. J Clin Endocrinol Metab. 2008; 93(4):1476-1481 (I.F. 5.873).

38. Heterozygous mutation of HESX1 causing hypopituitarism and multiple anatomical malformations without features of septo-optic dysplasia. Corneli G, Vivenza D, Prodam F, Di Dio G, A. Vottero, Rapa A, Bellone S, Bernasconi S, Bona G. J Endocrinol Invest. 2008; 31(8):689-93.

39. Dyslipidaemia, hepatic steatosis and selective post-receptor insulin resistance: insights from humans with insulin receptor and post-receptor signaling defects. R.K. Semple, A. Sleigh, P.R. Murgatroyd, C.A. Adams, L. Bluck, S. Jackson, A. Vottero, V. Charlton-Menys, P. Durrington, M.A. Soos, T.A. Carpenter, D.J. Lomas, E.K. Cochran, P. Gorden, S. O’Rahilly, D.B. Savage. JCI. 2009; 119(2):315-322.

40. Prevalence of pathogenetic MC4R mutations in Italian children with early onset obesity, tall stature and familial history of obesity. N. Santoro, G. Cirillo, Z. Xiang, R. Tanas, N. Greggio, G. Morino, L. Iughetti, A. Vottero, A. Salvatoni, M. Di Pietro, A. Balsamo, A. Crino, A. Grandone, C. Haskell-Luevano, L. Perrone, E. Miraglia Del Giudice. BMC Med Genet. 2009;10(1):25.

REVIEWS

1. Glucocorticoid receptor isoforms alpha and beta: potential physiologic and pathologic importance. A. Vottero, G.P. Chrousos. The Journal of Endocrine Genetics. 1999; 1(2): 61-71.

2. Glucocorticoid receptor : view I. A. Vottero, G.P. Chrousos. Trends Endocrinol Metab. 1999; 10 (8):333-338.

3. Adrenal hyperandrogenism in children. L. Ghizzoni, G. Mastorakos, A. Vottero. J Clin Endocrinol Metab. 1999; 84(12): 4431-4435.

CHAPTERS

1. Mineralocorticoid and glucocorticoid receptors. T. Kino, A. Vottero, G.P. Chrousos. Nuclear receptors and genetic disease. Eds. T.P. Burris and E.R.B. McCabe. Academic Press. 2001; 297-308.

2. Adrenal Hyperfunction. A. Vottero, L. Ghizzoni. Endocrinologia Pediatrica. Eds. S. Bernasconi, L. Iughetti, and L. Ghizzoni. McGraw-Hill Press. 2001;

3. Gynecomastia. A. Vottero, C. Pintor. Endocrinologia Pediatrica. Eds. S. Bernasconi, L. Iughetti, and L. Ghizzoni. McGraw-Hill Press. 2001;

4. Glucocorticoid resistance and hypersensitivity states. D.P. Franchimont, A. Vottero, T. Kino, G.P. Chrousos. Hormone resistance and hypersensitivity states. Eds. G.P. Chrousos, J.M. Olefsky, and E. Samols. Maple Press. 2002; 373-387.

5. Glucocorticoid resistance and hypersensitivity syndromes. A. Vottero, G.P. Chrousos. Oxford Textbook of Endocrinology and Diabetes. Eds. J.A.H. Wass, S.M. Shalet, and E. Gale and S.A. Amiel. Oxford University Press. 2002; 845-851.

6. Glucocorticoid resistance syndromes and states. A. Vottero, G.P. Chrousos. Encyclopedia of endocrine diseases. ED. L. Martini. Elsevier Inc. 2004; 235-241.

7. Glucocorticoid resistant syndromes and states. A. Vottero, G.P. Chrousos. Endotext.org.

8. Adrenal androgens. L. Ghizzoni, G. Mastorakos, A. Vottero. Endotext.org.

ABSTRACTS

1. Relative cortisol deficiency in patients with nonclassical steroid 21-hydroxylase deficiency (NCCAH). L.Ghizzoni, A. Vottero, R. Virdis, G. Caselli, L. Iughetti, C. Volta, S. Bernasconi. Abs # 1000. 75th Annual Meeting of the Endocrine Society. Las Vegas 1993.

2. Le problematiche nella definizione del deficit di GH. S. Bernasconi, C. Volta, L. Ghizzoni, L. Iughetti, A. Vottero. Incontro Internazionale di Endocrinologia dell’eta’ evolutiva. Padova 1993.

3. Malattia di Cushing in eta’ pediatrica associata ad un grave quadro osteoporotico. A. Vottero, L. Ghizzoni, G. Mazzardo, M.C. Baroni, R. Delsignore, S. Bernasconi. Societa’ Italiana di Medicina Interna. Parma 1994.

4. Pituitary-ovarian responses to leuprolide acetate testing in patients with classic congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency. L. Ghizzoni, A. Vottero, R. Virdis, M. Cappa, M.E. Street, M. Zampolli, L. Ibanez, S. Bernasconi. Abs # p2-74. 77th Annual Meeting of the Endocrine Society. Washington, DC 1995.

5. Autosomal dominant inheritance of Schmid’s metaphyseal chondrodysplasia: description of a new family , and investigation of the COL10A1 gene. C.A. Stratakis, A. Vottero, C.S. Mitsiades, V. Abbassi. Pediatr Res. 1996; 39(4): 148A.

6. The syndrome of increased aromatase activity causes isosexual precocious puberty in girls and prepubertal gynecomastia in boys: diagnosis, biochemical and molecular investigation in two generations and treatment. C.A. Stratakis, A. Brodie, D. DeAtkine, A. Vottero, W. Yue, A.W. Flor, A. Garnica, C.S. Mitsiades, G.P. Chrousos. 10th International Congress of Endocrinology (Endocrine Society). San Francisco, CA 1996.

7. Corticotropin-releasing hormone-induced inhibition of estradiol production by human granulosa-lutein cells. L. Ghizzoni, G. Mastorakos, A. Vottero, A. Barreca, M.A. Furlini, A. Cesarone, G.P. Chrousos, S. Bernasconi. 78th Annual Meeting of the Endocrine Society in conjunction with the 10th International Congress of Endocrinology. San Francisco, CA 1996.

8. Spontaneous cortisol and TSH secreation interactions in patients with nonclassic 21-hydroxylase deficiency (NCCAH) and control children. L. Ghizzoni, G. Mastorakos, M.E. Street, M.A. Magiakou, A. Vottero, A. Solazzi, G.P. Chrousos, S. Bernasconi. 35th Annual Meeting of European Society for Paediatric Endocrinology. Montpellier, 1996.

9. Biochemical and molecular genetics of the syndrome of increased aromatase activity: segregation with a marker from within the P450arom gene and evidencefor aberrant alternative splicing of its 5’-end mRNA. C.A. Stratakis, A. Vottero, A. Brodie, D. DeAtkine, Q. Lu, C.S. Mitsiades, G.P.Chrousos. The American Journal of Human Genetics. 1996; 59 (4): 216.

10. Carney complex segregates with markers from the chromosome 2p16 CNC locus in two new kindreds; placement of new markers, and integration of genetic and physical mapping in the region. A. Vottero, J-P. Lin, L. Aksentijevich, D.L. Kastern, J.A. Carney, G.P. Chrousos, C.A. Stratakis. The American Journal of Human Genetics. 1996; 59 (4): 1383.

11. Schmid metaphyseal chondrodysplasia: application of diideoxyfingerprinting (ddF) in the analysis of the COL10A1 gene in a new kindred, and identification of a novel (S671P) mutation at the NC1 domain. Z. Orban, C.A. Stratakis, A. Vottero, A.L. Burns, C.S. Mitsiades, S.J. Marx, V. Abbassi, G.P. Chrousos. The American Journal of Human Genetics. 1996; 59 (4): 1598.

12. The dominant negative effect of glucocorticoid receptor may explain glucocorticoid resistance in primates. A. Vottero, M. Castro, S. Elliot, M. Karl, C.A. Stratakis, G.P. Chrousos. NIH Research Festival, Bethesda, MD, 1996.

13. Glucocorticoid-induced apoptosis in B-cell chronic lymphocytic leukemia (B-cell) associated with the syndrome of glucocorticoid resistance. H. Shahidi, S.A. Gregory, C.A. Stratakis, A Vottero, T. Kino, M. Karl, G.P. Chrousos, JMD Plate. 38th Annual Meeting of the American Society of Hematology, Orlando, Florida, December 1996.

14. Familial aromatase excess syndrome: a clinical, genetic, and molecular investigation. A. Vottero, C.A. Stratakis, G.P. Chrousos. NIH Clinical Research Day, Bethesda, MD, 1997

15. Genetic and radiation hybrid map of the Carney complex (CNC) locus; construction of a yeast artificial chromosome (YAC)-based physical map. L.S. Kirschner, S. Taymans, A. Vottero, J.-P. Lin, C.A. Stratakis. Biomedicine ’97, Washington, DC, 1997.

16. Refinement of the genetic map of the Carney complex (CNC) locus, and construction of a yeast artificial chromosome (YAC)-based phisical map. L.S. Kirchner, A. Vottero, J.-P. Lin, C.A. Stratakis. 79th

Annual Meeting of the Endocrine Society, Minneapolis, MN, 1997.

17. Analysis of the polymorphic (CAG) microsatellite of the androgen receptor gene (exon 1) in patients with idiopathic hirsutism and normal controls. A Vottero, L. Ghizzoni, C.A. Stratakis, C. Longui, M. Karl, G.P. Chrousos. 79th Annual Meeting of the Endocrine Society, Minneapolis, MN, 1997.

18. Corticotropin-releasing hormone-induced inhibition of steroid biosynthesis by cultured granulosa-lutein cells is mediated by interleukin-1 (IL-1) receptors. L. Ghizzoni, G. Mastorakos, A Vottero, A. Barreca, M. Furlini, A. Cesarone, B. Ferrari, G.P. Chrousos, S. Bernasconi. 79 th Annual Meeting of the Endocrine Society, Minneapolis, MN, 1997.

19. Increased aromatase activity in transformed lymphoblastoid cell lines from patients with the familial aromatase excess syndrome and normal controls is associated with novel alternative splicing of the 5’-end of P450arom mRNA. C.A. Stratakis, A. Vottero, G.P. Chrousos. The Society for Pediatric Research (SPR) Annual Meeting, Washington, DC, 1997.

20. Identification of novel alternative splicing of the 5’-end of P450arom mRNA in peripheral blood lymphocytes from patients with familial aromatase excesssyndrome and normal controls. A. Vottero, C.A. Stratakis, G.P. Chrousos. 5th Meeting of European Society for Pediatric Endocrinology (ESPE), Hormone Research 1997; 48 (2): 1-212 (#5) .

21. Human glucocorticoid receptor- measurements by quantitative Western analysis suggest presence of large amounts of non-ligand-binding spare receptors. A. Vottero, S. Elliot, B.S.Warren, M. Karl, T. Kino, G.L. Hager, G.P. Chrousos. 5th Meeting of European Society for Pediatric Endocrinology (ESPE), Hormone Research 1997; 48 (2): 1-212 (#519).

22. X-chromosome inactivation: possible influence on phenotype of patients with idiopathic hirsutism. A. Vottero, L. Ghizzoni, C.A. Longui, M. Karl, C.A. Stratakis, G.P. Chrousos. 80th Annual Meeting of the Endocrine Society, New Orleans, LA, 1998 (oral presentation).

23. Glucocorticoid-receptor isoforms and dexamethasone-induced apoptosis in leukemia cell lines. C.A. Longui, A. Vottero, T. Kino, Y. Yang, V. Poulaki, G.P. Chrousos. 80th Annual Meeting of the Endocrine Society, New Orleans, LA, 1998.

24. Spontaneous leptin secretion and its interactionswith spontaneous growth hormone secretion in prepubertal children. L. Ghizzoni, G. Mastorakos, G. Mazzardo, M.E. Street, L. Petrucci, A. Vottero, G.P. Chrousos, S. Bernasconi. 80th Annual Meeting of the Endocrine Society, New Orleans, LA, 1998.

25. High variability of glucocorticoid receptor isoform in normal humans may explain physiologic differences in glucocorticoid sensitivity. A. Vottero, C.A. Longui, S. Elliot, G.P. Chrousos. ESPE Annual Meeting, Florence, Italy, 1998 (oral presentation).

26. Transient tranfection of and glucocorticoid receptor-expressing vectors in leukemic cell lines: effects on luciferase activity. C.A. Longui, A. Vottero, T. Kino, G.P. Chrousos. ESPE Annual Meeting, Florence, Italy, 1998.

27. Leptin-induced inhibition of estradiol production by human granulosa-lutein cells. L. Ghizzoni, M. Furlini, G. Mastorakos, B. Ferrari, A. Vottero, G.P. Chrousos, S. Bernasconi. ESPE Annual Meeting, Florence, Italy, 1998.

28. Spontaneous leptin secretion and its interactions with spontaneous growth hormone secretion in prepubertal children. L. Ghizzoni, G. Mastorakos, G. Mazzardo, M.E. Street, L. Petrucci, A. Vottero, G.P. Chrousos, S. Bernasconi. ESPE Annual Meeting, Florence, Italy, 1998.

29. X-chromosome inactivation: possible influence on phenotype of patients with idiopaathic hirsutism. A. Vottero, C.A. Longui, L. Ghizzoni, C.A. Stratakis, G.P. Chrousos. 12th Annual Meeting of the Latin-American Society for Pediatric Endocrinology, Sao Pedro, Brazil, 1998 (oral presentation).

30. Dexamethasone-induced apoptosis and glucocorticoid receptor isoforms in leukemic cells. C.A. Longui, A. Vottero, T. Kino, Y. Yang, G.P. Chrousos. 12th Annual Meeting of the Latin-American Society for Pediatric Endocrinology, Sao Pedro, Brazil, 1998.

31. A novel mutation of the glucocorticoid receptor in familial glucocorticoid resistance. A. Vottero, H. Combe, P. Lecomte, C.A. Longui, G.P. Chrousos. 81th Annual Meeting of the Endocrine Society, San Diego, CA, 1999 (oral presentation).

32. Glucocorticoid resistance in inflammatory diseases: no evidence for IL-4 and IL-2 regulation of glucocorticoid receptor RNA splicing to its two major isoforms. D.P. Franchimont, M. Gadina, A. Vottero, J. Galon, C.A. Longui, T. Kino, G.P. Chrousos. 81th Annual Meeting of the Endocrine Society, San Diego, CA, 1999.

33. Familial autosomal dominant pseudohypoaldosteronism (PHA): alteration in the expression of the glucocorticoid receptor. A. Vottero, G. Simic-Schleicher, G.P. Chrousos. ESPE Annual Meeting, Warsaw, Poland, 1999 (oral presentation).

34. Catecholamines in asymptomatic and symptomatic pseudohypoaldosteronism. G. Simic-Schleicher, A. Vottero, U. Neuudorf, B.P. Hauffa, G.P. Chrousos. ESPE Annual Meeting, Warsaw, Poland, 1999.

35. Individual expression and tissue distribution of the splice isoforms of the human growth hormone receptor (GHR). A. Vottero, S. Chava-Sarfaty, G. Miller, T. Lafferty, G.P.Chrousos, Z. Hochberg. 82nd

Annual Meeting of the Endocrine Society, Toronto, Canada, 2000.

36. Endocrine modulators of interlukin-6 secretion by human adypocites. V. Vicennati, A. Vottero, C. Friedman, D. Papanicolaou. 82nd Annual Meeting of the Endocrine Society, Toronto, Canada, 2000.

37. Interactions of leptin and thyrotropin 24-hour secretory profiles in short-normal children. L. Ghizzoni, G. Mastorakos, M. Ziveri, M. Furlini, A. Solazzi, A. Vottero, S. Bernasconi. 82nd Annual Meeting of the Endocrine Society, Toronto, Canada, 2000.

38. Transcriptional and translational regulation of the splicing isoforms of the GH receptor by glucocorticoids. A. Vottero, S. Chava-Sarfaty, J. Kratzsch, G.P.Chrousos, Z. Hochberg. ESPE Annual Meeting, Brussels, Belgium, 2000 (Henning Anderson Award; oral presentation).

39. Interlukin-6 and tumor necrosis factor in asymptomatic and symptomatic pseudohypoaldosteronism. G. Simic-Schleicher, A. Vottero, V. Vicennati, U. Neuudorf, B.P. Hauffa, G.P. Chrousos. ESPE Annual Meeting, Brussels, Belgium, 2000.

40. Peripheral IL-6 is not involved in the activation of the hypothalamic-pituitary-adrenal (HPA) axis by insulin-induced hypoglicemia. A. Vottero, G. Mastorakos, G.P. Chrousos, S. Bernasconi, L. Ghizzoni. EFES Annual Meeting, Turin, Italy, 2001.

41. Cross talk between leptin, cortisol, GH, and TSH. L. Ghizzoni, G. Mastorakos, A. Vottero, S. Bernasconi. EFES Annual Meeting, Turin, Italy, 2001.

42. Corticotropin-releasing hormone is directly affecting human adipose tissue functions. V. Vicennati, A. Vottero, E. Zoumakis, U. Pagotto, R. Pasquali, D.A. Papanicolaou. EFES Annual Meeting, Turin, Italy, 2001.

43. A novel dominant negative mutation of the glucocorticoid receptor causing familial glucocorticoid resistance: defective interaction P160 coactivators. A. Vottero, T. Kino, H. Combe, P. Lecomte, G.P. Chrousos. 83rd Annual Meeting of the Endocrine Society, Denver, CO, 2001.

44. Interleukin-6 promotes insulin resistance and lypolysis in human adipocytes. V. Vicennati, A. Vottero, C. Friedman, D.A. Papanicolaou. 83rd Annual Meeting of the Endocrine Society, Denver, CO, 2001

45. A clinical assay of the human growth hormone receptor (GHR) isoforms in peripheral blood lymphocytes (PBL). A. Vottero, S. Chava-Sarfaty, G.P.Chrousos, Z. Hochberg. LWPES7ESPE 6th Joint Meeting, Montreal, Canada, 2001.

46. Una nuova mutazione dominante negativa del recettore per i glucocorticoidi causa la sindrome da resistenza familiare ai glucocorticoidi: difetto nell’interazione con I coattivatori p160. A. Vottero, T. Kino, H. Combe, P. Lecomte, G.P. Chrousos. SIEDP, Trieste, 2001.

47. Interazioni tra leptina e cortisolo, GH e TSH. L. Ghizzoni, A. Vottero, G. Mastorakos, M. Ziveri, S. Bernasconi. SIEDP, Trieste, 2001.

48. Gender difference in lymphocytes aromatase gene expression. A. Vottero, C. Carani, M. Capelletti, V. Rochira, E. Valassi, T.M. Neri, S. Bernasconi, L. Ghizzoni.. 84dh Annual Meeting of the Endocrine Society, San Francisco, CA, 2002.

49. Differential interaction and activation function 2 of natural glucocorticoid receptor mutants causing familial glucocorticoid resistance. E. Charmandari, A. Vottero, A.C. Latronico, B. Mendonca, G.P. Chrousos, T. Kino. 84dh Annual Meeting of the Endocrine Society, San Francisco, CA, 2002.

50. The human glucocorticoid receptor (GR) beta isoform interacts with coactivators only through its transcriptional activation function (AF) 1 region and suppresses both AF1 and AF2 activities of GR beta. E. Charmandari, A. Vottero, G.P. Chrousos, T. Kino. 84dh Annual Meeting of the Endocrine Society, San Francisco, CA, 2002.

51. Quantificazione del trascritto del gene dell’aromatasi nei leucociti di donne, uomini e bambini. M. Capelletti, A. Vottero, K. Canali, C. Carani, S. Bernasconi, L. Ghizzoni, T.M. Neri. SIGU 2002, Verona, 2002.

52. Spontaneous 24-hour Ghrelin secretion in short-normal prepubertal children. L.Ghizzoni, A. Vottero, G. Mastorakos, F. Folli, M. Ziveri, S. Bernasconi. ESPE Annual Meeting, Madrid, Spain, 2002.

53. Quantification of human aromatase gene expression in peripheral blood leukocytes (PBLS). A. Vottero, T.M. Neri, S. Bernasconi, L. Ghizzoni.. ESPE Annual Meeting, Madrid, Spain, 2002.

54. Crescita ed espressione del gene dell’aromatasi. S. Bernasconi, A. Vottero, M. Capelletti, L. Ghizzoni. Palermo 2003.

55. Androgen receptor CAG repeats and gene methylation in children with premature pubarche. M. Capelletti, A. Vottero, T.M. Neri, S. Bernasconi, L. Ghizzoni. 85dh Annual Meeting of the Endocrine Society, Philadelphia, PA, 2003 (oral presentation).

56. Studio del numero delle triplette CAG e della metilazione del gene per il recettore degli androgeni in bambine prepuberi, donne e pazienti con pubarca prematuro. A. Vottero, M. Capelletti, S. Giuliodori, T.M. Neri, S. Bernasconi. SIEDP, Roma, 2003.

57. Secrezione spontanea delle 24 ore di Ghrelina in bambini prepuberi con bassa statura. L. Ghizzoni, A. Vottero, F. Folli F, M. Ziveri M, S. Bernasconi. SIEDP, Roma, 2003.

58. Spontaneous GH secretion is not directly affected by ghrelin either in short-normal prepubertal children or in children with GH neurosecretory dysfunction. L. Ghizzoni, G. Mastorakos, A. Vottero, M. Ziveri, I. Viani, S. Bernasconi. 86dh Annual Meeting of the Endocrine Society, New Orleans, 2004 (P2-414).

59. The human glucocorticoid receptor (hGR) beta isoform suppresses the transcriptional activity of hGR alpha by interfering with binding of hGR alpha to coactivators molecules through its preserved activation

function (AF)-1. E. Charmandari, G.P. Chrousos, N. Bhattacharyya, A. Vottero, E. Souvatzoglou, T. Kino. 86dh Annual Meeting of the Endocrine Society, New Orleans, 2004 (P2-140).

60. Androgen receptor gene methylation pattern in normal children and adults, and in premature pubarche patients. A. Vottero, M. Capelletti, S. Giuliodori, S. Bernasconi, L. Ghizzoni. 43 rd ESPE Annual Meeting, Basel, Sweetzerlan, 2004 (Clinical Focus, CF3-108).

61. Clinical significance of parental origin of the X chromosome in Turner syndrome (TS). L. Sagi, A. Gawlik, L. Ghizzoni, N. Zuckerman-Levin, A. Buyukgebiz, Y. Rakover, T. Bistritzer, O. Baruch, A. Vottero, E. Malecka-Tendera, Z. Hochberg. 43rd ESPE Annual Meeting, Basel, Sweetzerlan, 2004 (Clinical Focus, CF2-100).

62. Aromatase overexpression. A. Vottero. Genesis Meeting, Washington D.C., 2005 (invited speaker)

63. Premature pubarche as epiphenomenon of non-random androgen receptor gene methylation. A. Vottero, M. Capelletti, S. Giuliodori, I. Viani, T.M. Neri, S. Bernasconi, L. Ghizzoni. 87dh Annual Meeting of the Endocrine Society, San Diego, CA 2005 (OR34-2, oral presentation, travel grant).

64. Final height in girls with idiopathic central precocious puberty treated with GnRH analogue and oxandrolone. L. Ghizzoni, A. Vottero, S. Pedori, M.Verna, M. Cappa, S. Loche, S. Bernasconi. ESPE/LWPES 7th Joint Meeting Pediatric Endocrinology, Lyon, France, 2005 (P2-704).

65. Altezza finale di bambine affette da pubertà precoce centrale idiopatica trattate con l’analogo del GnRH ed oxandrolone. T. Luppino, A. Vottero, S. Pedori, M.Verna, M. Cappa, S. Loche, S. Bernasconi, L. Ghizzoni. XV Congresso Nazionanle SIEDP, Cagliari, 2005.

66. Analisi dei geni dell’asse melanocortinico in bambini con obesità ad esordio precoce: risultati preliminari di uno studio multicentrico. E. Miraglia del Giudice, G. Cirillo, G. Morino, L. Iughetti, A. Vottero, A. Salvatoni, M. Di Pietro, E. Modestini, A. Balsamo, M. Gennari, L. Perrone. XV Congresso Nazionanle SIEDP, Cagliari, 2005.

67. Aromatase overexpression. A. Vottero. Conference Alfred Jost 2006, Paris, 2006 (invited speaker).

68. Ghrelin-dependent regulation of estradiol secretion by human granulosa-lutein cells. I. Viani, A. Vottero, E. Cattani, T. Luppino, S. Bernasconi, B. Ferrari, L. Ghizzoni. 88dh Annual Meeting of the Endocrine Society, Boston, MA, 2006.

69. Decreased androgen receptor gene methylation in premature pubarche: a novel pathogenetic mechanism? A. Vottero, L. Ghizzoni, S. Bernasconi. The 4th biennal meeting Asia Pacific Paediatric Endocrine Society, Pattaya, Thailand, 2006.

70. Hyperandrogenism. A. Vottero. National Colombian Meeting, Medellin, Colombia, 2007 (Invited Lecture).

71. GnRH analogue and oxandrolone in precocious puberty. A. Vottero. National Colombian Meeting, Medellin, Colombia, 2007 (Oral presentation).

72. Genotype and 17-hydroxyprogesterone blood levels in italian children with premature pubarche due to nonclassic 21-hydroxylase. A. Vottero, O. Porzio, D. Carta, F. Pinna, G. Ubertini, N. Di Iorgi, F. Napoli, L. Melandri, S. Loche, M. Maghnie, M. Cappa, L. Ghizzoni . 89dh Annual Meeting of the Endocrine Society, Toronto, Canada 2007.

73. Inhibitory effect of ghrelin on human ovarian steroidogenesis. A. Vottero, I. Viani, F. Tassi, L. Melandri, G. Cremonini, S. Bernasconi, B. Ferrari, L. Ghizzoni. 46 th ESPE Annual Meeting, Helsinki, Finlandia, 2007 (Oral presentation).

74. Melanocortin-4-receptor molecular screening in a group of phenotypically obese children: report of two new mutations and lack of association to the early onset of the disease. N. Santoro, G. Cirillo, T. Romano, A. Capaldo, P. Marzuillo, G. Morino, L. Iughetti, A. Vottero, A. Salvatoni, M. Di Pietro, E. Modestini, A. Balsamo, M. Gennari, L. Perrone, A. Crinò. E. Miraglia del Giudice. 46 th ESPE Annual Meeting, Helsinki, Finlandia, 2007.

75. Nuovi geni coinvolti nella funzione dell’asse ipofisi-surrene. A. Vottero. XVI Congresso Nazionanle SIEDP, Parma, 2007 (Invitated Lecture).

76. Relazione tra genotipo e livelli sierici di 17-idrossiprogesterone in bambini italiani con pubarca prematuro secondario a deficit non classico di 21-idrossilasi. A. Vottero, O. Porzio, D. Carta, F. Pinna, G. Ubertini, N. Di Iorgi, F. Napoli, L. Melandri, S. Bernasconi, S. Loche, M. Maghnie, M. Cappa, L. Ghizzoni. XVI Congresso Nazionanle SIEDP, Parma, 2007.

77. Irsutismo e poi….. M. Marchesi, V. Raggi, A. Vottero, L. Ghizzoni, S. Bernasconi. XVI Congresso Nazionanle SIEDP, Parma, 2007.

78. In vitro modulation of androgen receptor gene methylation by steroids. A. Vottero, F. Tassi, I. Viani, S. Bernasconi, M. Marchesi, V. Raggi, L. Ghizzoni. 90dh Annual Meeting of the Endocrine Society, S. Francisco, CA 2008.

79. Absence of functional interaction between p23 and DNA methyltransferase 1 in steroid-stimulated fibroblasts. A. Vottero, I. Viani, F. Tassi, S. Bernasconi, M. Marchesi, V. Raggi, L. Ghizzoni. 47th ESPE Annual Meeting, Istanbul, Turchia, 2008.

80. Androgen receptor gene methylation in steroid-stimulated fibroblasts is mediated by dimethyltransferase 3a. A. Vottero, I. Viani, F. Tassi, S. Bernasconi, R. Minari, L. Ghizzoni. 91st Annual Meeting of the Endocrine Society, Washington DC, USA 2009.

Autorizzo il trattamento dei miei dati personali ai sensi del Decreto Legislativo 30 giugno 2003, n. 196 "Codice in materia di protezione dei dati personali”

Dott.ssa Alessandra Vottero