Agen infevi : ruolo eziologico primario o solo trigger?...Priyanka Sharma Roberto Benigni -99.5% of...
Transcript of Agen infevi : ruolo eziologico primario o solo trigger?...Priyanka Sharma Roberto Benigni -99.5% of...
Agen%infe)vi:ruoloeziologicoprimarioosolotrigger?RobertoFurlan
Monza,5giugno2017
Infec%onsinMS(andautoimmunity):- Causal- Co-factor- Protec%ve
Causal:EBV
PerronFerranteSotgiuDolei
Sriram
Prototypicalinfec0ousdiseasesandimmunedisorders
BachJF.NEnglJMed2002
Bacteriaandparasiteswithprotec0veeffectsinautoimmunedisease
Helminththerapy
KhanandFallon.IntJParasitol2013
Malariaandautoimmunediseases
• Thepresenceofaspa0alandtemporalclusterofMSoccurredaJermalariaeradica0on
• Correla0onbetweenA30-B18-DR3HLAhaplotype,MSandhighmalariaprevalenceareas
• SomeTNFpolymorphismsintheTNF-promoterregionalreadyassociatedwithbothmalariaandMSareupto100meselevatedamongstSardiniansascomparedtoSiciliansandanyotherpopula0onworldwide
PugliaSetal.Neurology2002Wirzetal.2004Fernandez-Arqueroetal.Neurology1999Knightetal.NatGenet1999McGuireetal.JInfectDis1999
Horubatoslidesa:MauraPuglia)MichelBrahicPriyankaSharmaRobertoBenigni