Patrizia Tosi UO Ematologia Rimini - ER Congressi - P...ness. skclctal involvement cspcci'lly of the...

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Laprognosidelmielomamultiplo,oggi:

DamalattiainguaribileamalattiaguaribilePatriziaTosi

UOEmatologiaRimini

Sarah Newbury 1844 Sopravvivenza 4aa dai primi sintomi

Annals NY Acad Sci 1958

Annals NY Acad Sci 1958

Cancerchemotherapyreports1962

Che cosa è cambiato?

Lacurvadose-rispostadelMelphalanSRE

Selby et al, BR J Haematol 1987 Attal et al NEJM 1996

We are indebted to Beth Wolmer for her persistence in recommending the clinical evaluation of thalidomide in the treatment of multiple myeloma……………… This article is dedicated to the memory of Ira Wolmer, M.D

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Haematologica 2018

Ravi et al, Blood cancer journal 2018

Ravi et al, Blood cancer journal 2018

“pathwaytocure”Eradicazionedelclone

Metodichepervalutarel’efficaciadeltrattamento(MRD)

Trattamentoprecoce

Nuovicriteridiiniziotrattamento

StudisulMMsmouldering

Identificazionedeipazientiadaltorischio

Trattamentiadhoc(potenziamentodell’immunoterapia?)