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C U R R I C U L UM V I T A E NOMEECOGNOME GIUSEPPELAURIAPINTERINDIRIZZO MILANO,VIALEGIUSTINIANO1TELEFONO 02-2394-4018FAX 02-2394-4057E-MAIL GIUSEPPE.LAURIAPINTER@ISTITUTO-BESTA.IT

GIUSEPPE.LAURIA@UNIMI.ITLUOGOEDATADINASCITA BELLUNO,22MARZO1965NAZIONALITÀ ITALIANACODICEFISCALE LRPGPP65C22A757P

FORMAZIONE

• LaureainMedicinaeChirurgiaconseguitaindata26/07/1991pressol’UniversitàdegliStudidiPadova• DiplomadispecializzazioneinNeurologiaconseguitoindata27/10/1997pressol’UniversitàdiFerrara

(110lode)• Periodidiformazioneestudioall’estero:

− Johns Hopkins University, Baltimora, USA, Dipartimento di Neuroscienze, (febbraio-novembre1997),ottenendounShort-TermMobilityProgramgrantdelConsiglioNazionaledelleRicerche

− Università di Barcellona, Centro di Elettromiografia e Controllo Motorio del Dipartimento diNeurologia,(giugno-agosto2001),ottenendounShort-TermMobilityProgramgrantdelConsiglioNazionaledelleRicerche

ABILITAZIONIECERTIFICAZIONI• Abilitazioneall'eserciziodellaprofessionediMedicoeChirurgoconseguitanellaprimasessione1992

pressol’UniversitàdegliStudidiPadova

• Iscrizioneall’albodell’OrdinedeiMedicieChirurghidellaProvinciadiBellunodal23/6/1992,n°1548,senzainterruzioni

• AbilitazioneaProfessoredi IfasciadiNeurologiaMED/26(Ministerodell’UniversitàeRicerca;Bando2012;DDn.222/2012)

• CertificazioneperDirettoridiStrutturaComplessaAreaOspedalieradellaScuoladiDirezioneinSanità(CSG DSCP 1401 edizione 2014 - Eupolis Lombardia) organizzato in ottemperanza al DPR 484/97,superandol’esamefinaleesostenendoladiscussionedelprojectworkindata25/09/2014

POSIZIONEATTUALE• Professore Ordinario, Università di Milano, settore MED/26 - Neurologia presso il Dipartimento di

Scienze Biomediche e Cliniche “L. Sacco” con funzioni assistenziali assegnate presso la FondazioneIRCCSIstitutoNeurologico“CarloBesta”diMilanoinqualitàdi:− DirettoreUnitàOperativaComplessaNeurologia3–Neuroalgologia(dal17/12/2015atutt’oggi)− DirettoredelDipartimentodiNeuroscienzeCliniche(dal16/11/2016atutt’oggi)− DirettoreScientificoVicario(dal1/6/2016atutt’oggi)

POSIZIONIPRECEDENTI• ProfessoreAssociatoUniversitàdiMilano,settoreMED/26dal11/10/2017al31/6/2018• IncaricodiDirezionediStrutturaComplessadell’UOCNeurologia3–NeuroalgologiadellaFondazione

IRCCSIstitutoNeurologico“CarloBesta”,Milanodal01/09/2013al16/12/2015• ResponsabileSOSDDayHospitaldellaFondazioneIRCCSIstitutoNeurologico“CarloBesta”,Milanodal

02/08/2010al01/09/2013• DirigenteMedicoIlivellopressol’UOCMalattieNeuromuscolarieNeuroimmunologia(NeurologiaIV),

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dellaFondazioneIRCCSIstitutoNeurologico“CarloBesta”,Milano,dal1/04/2004al31/08/2013• RicercatoreUniversitario, per concorsopubblicodi valutazioneper titoli edesame,presso laClinica

Neurologicadell’UniversitàdiBrescia,SpedaliCivilidiBrescia,dal15/11/2002al31/03/2004;nelcorsodel periodo ha svolto attività di responsabile di reparto e responsabile del Centro Neuropatie edAtassie;ha inoltresvoltoattivitàdidocenzaper ilCorsodiLaurea inOdontoiatria, inFisioterapia, inScienzeInfermieristicheeperlaScuoladiSpecializzazioneinNeurologiadell’UniversitàdiBrescia

• Borsista di ricerca, per concorso pubblico di valutazione per titoli ed esame, nell’ambito delprogrammadi ricerca«Studiodelleneuropatie ereditarie ed acquisite»presso l’IstitutoNeurologicoCarlo Besta, Milano, dal 15/5/1999 al 30/4/2000; dal 15/5/2000 al 30/4/2001 e dal 15/4/2001 al15/3/2002

• Collaborazione coordinata continuativa nell’ambito del programma di ricerca «Studio dellemalattiedegenerative del sistema nervoso centrale e periferico», presso l’Istituto Neurologico Carlo Besta,Milano,dal15/11/1998al30/04/1999

• Assistente Medico supplente, disciplina Neurologia dal 1/10/1993 al 28/12/1993 con rapporto atempopienopressolaDivisionediNeurologiadell’OspedalediBelluno

• Responsabile della Linea di Ricerca Corrente Ministeriale dell’Istituto Neurologico Carlo Besta daltitolo: Dolore Neuropatico e neuropatie periferiche nel triennio 2009-2011, inclusiva dei seguentiargomenti: 1) Neurobiologia e modelli sperimentali per lo studio della patogenesi del doloreneuropatico;2)Farmacogenomicadeldoloreneuropatico;3)Modelli sperimentali invitroed invivoperlostudiodelleneuropatieperiferiche;4)Patogenesi,clinica,geneticamolecolare,markersbiologicieterapianellepatologiedelsistemanervosoperifericoedelsistemanervosoautonomo

ATTIVITÀDIDATTICA

• CoordinatoredelMasterinternazionalediIIlivello“PeripheralNervousSystemDisorders”,UniversitàdiMilanoA.A.2018–2020(http://www.pns-master.eu/)

• CoordinatoreMarieSkłodowska-CurieInnovativeTrainingNetworks-2016/H2020-MSCA-ITN-2016• Docente del Corso di Laurea di Medicina e Chirurgia, Università di Milano, Polo Vialba, dall’A.A.

2017/2018• DocentedelDottoratoinScienzeBiomedicheeBiotecnologiche,UniversitàdegliStudidiFerrara,dal

2012atutt’oggi• DocentedellaScuoladiSpecializzazione inNeurologia,ClinicaNeurologica,UniversitàdiFerrara,dal

2007atutt’oggiinqualitàdiVisitingProfessor• ScuoladiSpecializzazioneinNeurologia,UniversitàdiBrescia;daaprile2004algiugno2013inqualità

diProfessoreacontratto• Corso di Laurea in Odontoiatria, in Fisioterapia, in Scienze Infermieristiche e per la Scuola di

SpecializzazioneinNeurologianelperiododal15/11/2002al31/03/2004inqualitàdiRicercatoredellaClinicaNeurologica,UniversitàdiBrescia

• Correlatoreper tesidi Laurea inMedicinaeChirurgia,OdontoiatriaeBiologia,di Specializzazione inNeurologia,e tutorperdottorandidelleUniversitàdiMilano,Brescia, Ferrara,MilanoBicoccaeSanRaffaelediMilano

• Membroesterno incommissionedivalutazionefinaleper ilconseguimentodeltitolodidottorato inNeuroscienzedalleUniversitàdiRotterdam,NL(2010)eAnversa,NL(2016)

ATTIVITÀSCIENTIFICA

Indicidiproduttivitàscientifica:− Co-autoredi237pubblicazioniinrivisteindicizzate,dicui98comeprimo,ultimoocorresponding

author− Co-autoredi16capitoliinlibri− Co-editoredi3libri− H-index(Scopus)54

SocietàScientifiche:• PeripheralNerveSociety(membroelettodelBoardofDirectors2007-2011)

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• Associazione Italiana SistemaNervoso Periferico della Società Italiana diNeurologia (membro elettodelComitatoScientifico2004-2012)

• SocietàItalianadiNeurologia-MembroelettodelConsiglioDirettivo(2019-)

Attivitàeditorialescientificainqualitàdi:• Editor-in-ChiefdelJournalofthePeripheralNervousSystem(2018-)• EditoreAssociatodelJournalofthePeripheralNervousSystem(dal2011al2018)• Revisore per numerose riviste scientifiche tra le quali: The New England Journal of Medicine, The

Lancet,TheLancetNeurology,Brain,Neurology,Diabetes,DiabetesCare,Muscle&Nerve,AnnalsofNeurology, European Journal of Neurology, European Journal of Pain, Journal of NeurologyNeurosurgeryandPsychiatry,JournalofNeurology,NeurologicalSciences,PlosOne,Cochrane

• Revisore per Società Italiana di Neurologia (SIN), Peripheral Nerve Society (PNS); EuropeanNeurological Society (ENS); European Federation of the Neurological Societies (EFNS), EuropeanAcademyofNeurology(EAN)

Revisorescientificoperagenziedifinanziamentoallaricerca:• European Research Council; European Commission; French National Research Agency; Faculty of

Medicine of the Imperial College of London;Medical Research Council, UK; Austrian Science Fund;PrinsesBeatrixFonds,TheNetherlands

DisegnodiLineeguidainNeurologiainqualitàdi:• Membro-CONCEPPTBoardonSmallFiberNeuropathy,WashingtonDC,April4-6,2018• Coordinatore - EFNS/PNS guidelines on the use of Skin Biopsy in the Diagnosis of Small Fibre

Neuropathy(2010)• Membro-BoardfortherevisionoftheGuidelinesintheDiagnosisofDiabeticNeuropathy(NeuroDIAB

2009)• Membro-BoardoftheAmericanAcademyofNeurology,theAmericanAssociationofNeuromuscular

andElectrodiagnosticMedicine, and theAmericanAcademyofPhysicalMedicineandRehabilitationforrevisionofthePracticeParametersforevaluationofdistalsymmetricpolyneuropathy(laboratoryandgenetictesting,autonomictesting,nervebiopsy,andskinbiopsy)(2009)

• Coordinatore-BoardfortheEFNSguidelinesontheuseofSkinBiopsyintheDiagnosisofPeripheralNeuropathy(2005)

FINANZIAMENTI(PEER-REVIEWED)-COORDINATORE

2019− CALLHUBRICERCAEINNOVAZIONE,RegioneLombardia"Innovation,newtechnologicalmodelsand

networkstocureALS(INTERSLA)"2017− GBS/CIDPFoundationInternationalProbingtheroleofskinbiopsyinCIDPnodo-paranodopathies-Co-

PIRaffaellaLombardi(€50,000)2016− EUROPEANCOMMISSIONMarieSkłodowska-CurieInnovativeTrainingNetworks-H2020-MSCA-ITN-

2016/H2020-MSCA-ITN-2016(Grant:721841-PAIN-Net;€3.354.464,57)− Fondazione Regionale per la Ricerca Biomedica (FRRB), Regione Lombardia "Translating molecular

mechanismsintoALSriskandpatients’well-being(TRANS-ALS)(Rif.20l5-0023;€4.314.463)2013− EUROPEAN COMMISSION FP7-HEALTH-2013-INNOVATION-1 Probing the Role of Sodium Channels in

PainfulNeuropathies(PROPANESTUDY-GrantNo:602273-2;€4.845.089)− Agenzia Italiana per la Ricerca nella SLA (AriSLA) 2013 - Proteinmisfolding, ALS and guanabenz: a

phaseIIRCTwithfutilitydesign(PROMISEtrial;FGCR01/2013;€300.000)2010− AgenziaItalianaperlaRicercanellaSLA(AriSLA)2010–ErythroPoietininALS:astudyofdose-finding

andsafety(EPOSSstudy;€296.000)

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− Italian Ministry of Research and University (MIUR) 2011 PON grant - Research and Developmentbioregulatorsactiveonepigeneticmechanismsofinflammatoryprocessesinchronicanddegenerativediseases(BIAM-EPI;€150.000)(Unitcoordinator)

2008− GBS/CIDPFoundationInternationalgrant2008AutonomicfailureandpaininGuillain-Barrésyndrome

(coordinators:PetervanDoorn–UniversityofRotterdam,GiuseppeLauria;€25.000)2007− ItalianMinistry of Health – Ricerca Finalizzata 2007-2009: Evaluation of the diagnostic process for

neuromusculardiseases in ItalianNeurologicalCentres (PIGraziellaFilippini;Co-PIGiuseppeLauria;€150.000)

2006− Italian Ministry of Health – Ricerca Finalizzata 2006-2008: Endogen and exogen mediators to

counteractnervedamageduetoantineoplasticdrugs(€550.000)2005− Regione Lombardia – Ricerca Finalizzata 2005 (DGR. VII/13235 del 9.6.2003, in attuazione al PSSR

2002-2004) – A randomized, double blind, placebo-controlled study to assess the efficacy ofelectroacupunctureinchronicneuropathicpain.(€50.000)

2004− EuropeanFederationoftheNeurologicalSocietiesgrant2004−Developmentofguidelinesfortheuse

ofskinbiopsyinthediagnosisofperipheralneuropathies(€5.000)2000− ItalianAssociationofDiabetologistsgrant2000-2001−Earlydiagnosisofdiabeticneuropathywithskin

biopsy(Lire5.000.000)

FINANZIAMENTI(UNRESTRICTEDGRANTS)-COORDINATORE

− LaViallasrl,Arezzo,Italy,2016-EffectofAqueousOlivePulpExtractinexperimentaldiabetes− LaViallasrl,Arezzo,Italy,2014-EffectofAqueousOlivePulpExtractinexperimentalmodelsofdiabetic

andchemotherapyneuropathies− CLSBehringGmbH-IndependentResearchGrant2013-SkininnervationinCIDP.Amulticentrestudy

onbiomarkersoftreatment− IRCCS Fondazione Istituto Neurologico“Carlo Besta” 2009 – Efficacy and safety of erythropoietin in

amyotrophiclateralsclerosis–TheEPOStrial− Epitech - Independent ResearchGrant2009 –Efficacy of PEA in the regeneration of humandiabetic

neuropathy.Pilotstudy.− Chiesi Farmaceutici – DEMAND study 2003 -2008−Amulticenter, randomized, prospective, double-

blindstudytoevaluatethenephroprotectiveandneuroprotectiveeffectofdelaprilaloneorcombinedwithmanidipineinpatientswithtype2diabetes.(coordinatoresottoprogettoneuropatiadiabetica)

− Grünenthal-FormentiIndependentResearchGrant2007−Efficacyofbuprenorphineinanimalmodelsofpainfulneuropathy(co-coordinatorProf.G.Cavaletti,UniversitàMilanoBicocca)

− PfizerUSA - IndependentResearchGrant2006−Evaluationof theanalgesicactivityofpregabalin inBurningMouthSyndrome

− AgaveIndependentResearchGrant2007−Evaluationofneuroprotectiveeffectofalfa-lipoicacidininvitromodelsoftoxicneuropathy.

− Grünenthal-Formenti-IndependentResearchGrant2005−EvaluationoftheefficacyofbuprenorphineTDSinpainfulneuropathies

− Rotary Club Belluno 1992 – Epidemiological study on cerebrovascular diseases in the Province ofBelluno,Italy

CLINICALTRIALS(PRINCIPALINVESTIGATOR)

− Vertex-APhase2,Randomized,Double-blind,Placebo-controlled,6-Week,Parallel-designStudyoftheEfficacy and Safety of VX-150 in Treating Subjects With Pain Caused by Small Fiber Neuropathy(EudraCTNumber:2017-001042-10)

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− Biogen-Aphase2,parallelgroup,randomized,double-blindplacebo-controlledstudytoevaluatetheefficacyandsafetyofBIIB074insubjectswithsmallfibreneuropathy

− CSL BehringGmbH -Multicenter, open-label extension study to investigate the long-term safety andefficacyof IgPro20 inmaintenance treatmentof chronic inflammatorydemyelinatingpolyneuropathy(CIDP) in subjects completing study IgPro20_3003 (Protocol Number:IgPro20_3004) (nationalcoordinator)

− CSLBehringGmbH-Randomized,multicenter,double-blind,placebo-controlled,parallel-groupphaseIIIstudyto investigatetheefficacy,safety,andtolerabilityof2differentdosesof IgPro20(subcutaneousimmunoglobulin)forthetreatmentofchronicinflammatorydemyelinatingpolyneuropathy(CIDP)–thePATHstudy(ProtocolNumber:IgPro20_3003)

− LFB Biotechnologies - An international, multicentre, efficacy and safety study of I10E in initial andmaintenancetreatmentofpatientswithChronicInflammatoryDemyelinatingPolyradiculoneuropathy

− King’s College London, Guy’s & St Thomas’ NHS Foundation Trust -RMC Trial - A Pilot RandomisedcontrolledtrialofMethotrexateforChronicInflammatoryDemyelinatingPolyradiculoneuropathy

− EliLilly-F1J-EW-HMGQ“UseofDuloxetineorPregabalininMonotherapyversusCombinationTherapyof Both Drugs in Patients with Painful Diabetic Neuropathy “The COMBO - DN (COmbination vsMonotherapyofpregaBalinanddulOxetineinDiabeticNeuropathy)Study”

− Grünenthal-FormentiIndependentResearchGrant2007(nationalcoordinator)−Safetyandefficacyoflidocaine5%medicatedplaster in comparisonwithpregabalin in postherpetic neuralgia anddiabeticpolyneuropathicpain”(KF10004/03)

− IRCCS Fondazione “Carlo Besta” 2009 – Efficacy and safety of erythropoietin in amyotrophic lateralsclerosis–TheEPOStrial

− Chiesi Farmaceutici – DEMAND study 2003 -2008−Amulticenter, randomized, prospective, double-blindstudytoevaluatethenephroprotectiveandneuroprotectiveeffectofdelaprilaloneorcombinedwithmanidipineinpatientswithtype2diabetes(neuropathysubstudycoordinator)

− PierreFabre-StudyoftheanalgesiceffectsofrepeateddosesofF13640inspinalcordinjurypatientswithmoderate to severe central neuropathic pain. Amultinational, multicenter, randomized, doubleblind,parallelgroups,placebo-controlledstudy(StudycodeF13640GE210)

− European Neuromuscular Centre - Peripheral Neuropathy Outcome Measures Standardisation(PeriNomS) study. A multicentre international study on outcome measures in autoimmunepolyneuropathies.

− AIFAbandi2006-Sperimentazioneclinicacontrollatapertrattamentoconeritropoietinainpazienticonatassia di Friedreich: studio pilota per l'ottimizzazione del dosaggio e delle modalità disomministrazioneperuntrattamentoalungotermine(IstitutoNeurologico“CarloBesta”)

− Epitech 2010 Independent Research Grant - Neuroprotective effect of palmitoylethanolamide indiabeticneuropathy:apilotstudy

− “La Sapienza” University - Neuropathic pain in Italy (NeuP-Italy). Prevalence and characteristics ofneuropathic pain in diabetic neuropathy, traumatic and postsurgical neuropathies, multiple sclerosisandstroke

RICONOSCIMENTI

− EuropeanNeurologicalSociety2002–bestscientificcontributionon“Peripheralneuropathies”− EuropeanNeurologicalSociety2004–bestscientificcontributionon“Peripheralneuropathies”

LETTUREMAGISTRALI,SEMINARIECORSIDIAGGIORNAMENTO

2019− 50thMeeting of the Italian Neurological Society, Bologna, October 12-15, 2019 - Small fibre

neuropathyinfibromyalgia− Le malattie Neuromuscolari - Competenze integrate nel percorso diagnostico-terapeutico”,

PordenoneSeptember26,2019-TerapienellaSLA:ieri,oggiedomani− International Society of Peripheral Neurophysiological Imaging, 8th Annual Meeting, 19-21

September2019,Trieste-Painfulneuropathiesdiagnosisandtreatment

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− ArthurK.Asbury:GBS/CIDP/InflammatoryLectureClinical–PeripheralNerveSociety,Genoa,June22-26-SkinforNeurologists

− National Academy of Medicine, Diagnostic and therapeutic update in clinical neurophysiology.Venice,February8,2019-Painfulneuropathies

− DptofNeurology,UniversityofGenova,January14,2019-Painfulneuropathiesandskinbiopsy2018− BritishPeripheralNerveSociety,London,UK,November9,2018–Painfulneuropathies− 5thInternational Congress on Neuromuscular Diseases (ICNMD2018), Vienna, July 6-8, 2018 – Skin

biopsy,notjustfordiagnosis− National Academy of Medicine, Diagnostic and therapeutic update in clinical neurophysiology.

Venice,February9-10,2017-Painfulneuropathies2017− WeillCornellMedicine-Qatar,DptofNeurosciencesGrandRounds,Doha,Qatar,December17,2017-

Bigpain,smallfibers:personalisingmedicineinpainfulneuropathies− Integrated Approach to NeurologicalManifestations (IANM 2017), Istambul, Turkey, December 14,

2017–Geneticpainfulneuropathies− XLVIIIMeetingoftheItalianNeurologicalSociety,Naples,October14-17,2017

o Ilsignificatodell'analisidell'innervazionecutaneanellepatologiedelsistemanervosoo PerchépartecipareadunTrial terapeuticooadunostudioosservazionale:dalla ricercaalmondo

reale− III corso di aggiornamento Teorico–pratico Update diagnostico e Terapeutico sulle Neuropatie

periferiche,Rovigo,September29,2017–Smallfibreneuropathy− 62thMeetingoftheItalianNeurophysiologySociety,Ferrara,June22,2017-Variantigenetichedelle

neuropatiedellepiccolefibre− IonChannelModulationSymposium,Cambridge,UK,June20th,2017-Sodium-channelrelatedpainful

neuropathies− 6th International Congress on Neuropathic Pain (NeuPSIG 2017),Gothenburg, Sweden, 15-18 June,

2017-Skinbiopsyasagold-standardforassessingtheIENFD− University of Venice Ca’ Foscary, Dpt of Computer Sciences, Venice 9 June, 2017 – Numbers and

neuroscience:towardprecisionmedicine− XIXUpdateCourse,Peripheralneuropathies in infancy:clinical-diagnosticandtherapeuticalupdate

of genetic and inflammatory forms, Fondazione Mariani, Milano, March 21, 2017 – Painfulneuropathies

− UniversityofPadova,DptofNeurology,March7,2017–Clinicaegeneticadeldoloreneuropatico− NationalAcademyofMedicine,Diagnosticandtherapeuticupdateinclinicalneurophysiology.Venice,

February9-10,2017o Painfulneuropathieso Clinicandneurophysiologicdiagnosisofmotorneurondiseases

− Italian Association for the Study of the Autonomic Nervous System, Palermo, February 8, 2017 -Painfulneuropathies

2016− ANIRCEF-SISC – II Congresso Nazionale Congiunto, Bologna, 25 Novembre 2016 – Genetics of

neuropathicpain− Italian Peripheral Nerve Association - Corso teorico–pratico di alta formazione ulle neuropatie

perifericheModuloneuropatiedellepiccolefibre.IIEdizioneTeleseTerme(BN),21novembre2016–Paingenetics

− Italian Neurology Society, ALS Study Group, Venice, October 24, 2016 – From pathogenicheterogeneitytonoveltherapeutictargetsinamyotrophiclateralsclerosis

− II Corso di Aggiornamento Teorico–Pratico, Update Diagnostico e Terapeutico sulle NeuropatiePeriferiche–Rovigo,September16,2016-Smallfibreneuropathies

− InternationalCongressonNeuromuscularDiseases,Toronto,July4-9,2016–DiagnosisofSmallFiberNeuropathy

− NationalAcademyofMedicine,Diagnosticandtherapeuticupdateinclinicalneurophysiology.Venice,

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February152016-Neuropatieiperalgiche.2015− Gordon Research Conference on Barrier Function of Mammalian Skin, Waterville Valley, NH (USA),

August16-21,2015–Theskinasanociceptor− XLVI Italian Neurological Society meeting, Workshop "Update sul dolore neuropatico" Genova,

October 11, 2015 - Il dolore nella neuropatia delle piccole fibre: dai meccanismi fisiopatologici altrattamento

− ItalianPeripheralNerveSocietyannualmeeting.Torino,April9-11,2015–GeneticsandEpigeneticsofPain

− France-ItalianMeetingonPeripheralNervousSystemDiseases,Centred’InformationScientifiquedel’InstitutPasteur,Paris,January30-31,2015–Smallfibres,sodiumchannelsandpain

− UniversityofFirenze,DptofPharmacology,March19-21,2015-Geneticsofneuropathicpain− NationalAcademyofMedicine,Diagnosticandtherapeuticupdateinclinicalneurophysiology.Venice,

February 19-21, 2015. Present and future of diagnostic techniques for painful neuropathies andtherapeuticchallenges

2014− BrazilianAcademyofNeurology,Curitiba(Paraná),Brazil,November8-12,2014.

o Skinbiopsyforthediagnosisofpainfulandimmunemediatedneuropathies.o Neuropathicpaindiagnosis:challengeandpossibilities.o Somaticsmallfibreneuropathy–anupdate

− 16thEuropeanFederationofAutonomicSocietiesmeeting&4thschool,Malaga,Spain,9-11thOctober2014ChannelopathiesandAutonomicNervousSystem

− Nervecon2014,Nizam's InstituteofMedical Sciences,Hyderabad, India -PeripheralNerveDisordersSymposiumonbehalfofthePeripheralNeuropathyFoundation.August2-3,2014.

o Diabeticneuropathy-Anupdateo Channelopathiesandpainfulneuropathyo Paraneoplasticneuropathies-Newconceptsandtreatment

− Peripheral Nervous System in development and disease. International training course on PNSdevelopment, function, disease, regeneration and remyelination. Lecce, Italy, July 1-4, 2014.Painfulneuropathiesandsodiumchannels.

− 3rdJointMeetingBelgian-DutchNeuromuscular,Vaals(NL)May9,2014.Painfulneuropathies− 7thWorldCongressoftheWorldInstituteofPain,Maastricht(NL)May8,2014.Diagnosisandclinical

implicationsofsmallfiberneuropathy2013− PeripheralNerveSocietyTeachingCourse-BelgradeNeuropathyUpdate,Belgrade,April4-6,2013.

o Skinbiopsyinneurologyo Treatmentofpainfulneuropathies.

− NationalAcademyofMedicine,Diagnosticandtherapeuticupdateinclinicalneurophysiology.Venice,February 13-15 2014. Present and future of diagnostic techniques for painful neuropathies andtherapeuticchallenges

− ItalianSocietyofDiabetology,Riccione,21ottobre2013.Painfuldiabeticneuropathy:Pathophysiologyanddiagnosis

− SanRaffaeleUniversityHospital,Milano18ottobre2013. Imaging inNeuromuscular andPeripheralNerveDiseases:stateoftheart.Skinbiopsyinpainfulandinflammatoryneuropathies

− NeuroDiab2013,Barcelona,September21st,2013.Sodiumchannelsanddiabeticpainfulneuropathy:Themissinglink.

− 23rd EuropeanNeurological Society, Barcelona, June 11, 2013.Teaching course onGenetics of pain -Mutationsinsodium-channelgeneandgeneticpaindisorders.

− NationalAcademyofMedicine,Diagnosticandtherapeuticupdateinclinicalneurophysiology.Venice22-24February,2013.Painfulneuropathies

− 196thENMCInternationalWorkshop:“OutcomeMeasuresinInflammatoryPeripheralNeuropathies”8-10 February 2013, Naarden, The Netherlands. Is there a place for skin biopsy as an outcome ininflammatoryneuropathies?

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2012− Incontro Nazionale Neurofisiologia: Nuove Strategie. Palermo, 29-30 novembre 2012 - Controversie

sulladiagnosieterapiadeldoloreneuropatico− Università di Bologna, Le molteplici facce del sintomo dolore., 3 ottobre 2012 –Neurobiologia del

doloreegenetica− XLIIICongressodellaSocietàItalianadiNeurologia.Rimini,6ottobre2012–Leneuropatiesensitivee

dolorose− 16thCongressoftheEuropeanFederationofNeurologicalSocieties,Stockholm,Sweden,September

8-11,2012–Workshoponclinicalmeasuresinneuropathies− American Academy of Neurology, New Orleans, April 25, 2012 – Education Program: Small fiber

neuropathy:somatic,autonomic,andboth− NationalAcademyofMedicine,Diagnosticandtherapeuticupdateinclinicalneurophysiology.Venice

January19-21,2012–Painfulneuropathies2011− UniversityofBrescia,January27,2012–Skinbiopsyinthediagnosisofperipheralneuropathies− XXWorldCongressofNeurology,Marrakesh,Morocco,November16,2011–AdvancesinNeuropathy:

SkinBiopsy− EFICHamburg,September23,2011-Skinbiopsyasadiagnostictoolinneuropathicpain− 21st Annual Meeting of the Diabetic Neuropathy Study Group of the EASD, September 10, 2011,

Porto(P)–Skinbiopsyindiabeticneuropathy− EuropeanAssociationfortheStudyofDiabetes,Lisbon,12-16September2011-Skinbiopsy:research

toolorroutinediagnosticprocedure?− European Neurological Society, Lisbon, 28 May 2011 - Histopathological landmarks of small fibre

neuropathyandhowtheycorrelatewithotherdata− UniversitàdiFerrara, IVCorsoTeorico-Praticosu“ladiagnosidelpazientecondoloreneuropatico. Il

contributo della neurofisiologia clinica” Ferrara, 26 Maggio 2011 - “Biopsia di cute e doloreneuropatico:update”

2010− XLI Meeting of the Italian Neurological Society (SIN), October 25, 2010, Catania – Diabetic

Neuropathies− 13th World Congress on Pain, Official Satellite Symposium, Montreal, August 28th, 2010 – Burning

MouthSyndrome:histologicalfeatures− EuropeanFederationoftheNeurologicalSocieties,NeuromuscularDiseasesTeachingCourse,Geneve,

September25th,2010–Cutaneousbiopsy− PeripheralNerveSociety,Sidney,July4,2010–Skinbiopsyinimmune-mediatedneuropathies− EuropeanNeurologicalSociety,Berlin, June26,2010–Skinbiopsy in themanagementofperipheral

neuropathies− Queen’s Square Institute of Neurology, UCL, London, April 6, 2010 - Skin biopsy in peripheral

neuropathies− 10th Course on Therapeutic Frontiers in Neurology, Bergamo,March 13, 2010 -Neuroprotection of

PeripheralNerves2009− NeuroDiab ConsensusMeeting:Revision of the guidelines for the diagnosis of diabetic neuropathy,

Toronto,Oct13-15,2009− XLMeetingof the ItalianNeurological Society (SIN),November21-25,2009,Padova -Neuroscience

andPainStudyGroup–Nervebiopsyandskinbiopsyinpainfulneuropathies− WorkshopoftheItalianALSstudygroup,November13-15,Genova–NeurotrophicfactorsinALS− VIII Convegno Nazionale Area Culturale Dolore (ACD) SIAARTI, Roma 11-13 Novembre 2009 -

Buprenorfina:dallafarmacologiaallaclinicanelpazientecondoloreneuropatico− EuropeanNeurologicalSociety,SymposiumforIndianNeurologists,25-26July2009,Chennai,India–

Neuropathic pain; Clinical, Neurophysiological, and Neuropathological Features of PeripheralNeuropathies

− XLVCongressoAssociazioneItalianaNeuropatologia,3-6June,2009,Bologna

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− ConsensusConferenceonChiariSyndrome: aMalformationoranAnomaly?–Medical treatmentofneuropathicpain,7-9May,2009,Milan

2008− LXIIICongresoChilenoNeurologíaPsiquiatríaNeurocirugía,ViñaDelMar,Chile,November2008

o Painfulneuropathies:fromsymptomstoneuropathologyo Applicationofskinbiopsyinhumanneuropathiesandexperimentalmodels

− CongresoAnualde LaSociedadEspañolaDeNeurologia,Barcelona,November27,2008,DiagnosticCriteriaForSmallFiberNeuropathy,

− University of Basel, Continued Medical Education seminars for Neurology, October 2, 2008 - Skinbiopsyforperipheralneuropathiesinclinicalpractiseandresearch

− EuropeanNeurologicalSociety,NiceJune7,2008–Skinbiopsiesandtheiruseindiagnosingperipheralneuropathies

− University of Rotterdam, Dpt of Neurology, May 27, 2008 - Neuropathic Pain and InflammationSymposium:Skinbiopsyandpain

− 48°CongressodellaSocietàNazionalediNeurologia,Milano22maggio2008–Neuropatiedolorose:daisintomiallaneuropatologia

2007− XXXVIII Congresso della Società Italiana di Neurologia, Firenze Ottobre 2007 – Utilità della

neuropatologianellaneurologiaclinicaattuale− HôpitaldelaPitiéSalpétrière,Paris-Gennaio2007-Controversiesontheuseofskinbiopsy.− UniversidaddeBarcelona-HopitalClinic,DptofNeurology–12Feb2007–Skinbiopsyinthediagnosis

ofperipheralneuropathies.− Updates inClinicalNeurology -SezioneLombardaSIN-SNO,Brescia30marzo2007−Ladiagnostica

strumentalenelleneuropatieperiferiche− 30° Congresso dell’Associazione Italiana Studio Dolore, Assisi 25maggio 2007 − Trattamento della

neuropatiadolorosa2006− XXXVIICongressodellaSocietàItalianadiNeurologia,Bariottobre2006–Biopsia:oltreilsurale− 60°CongressoNazionaleSIAARTI,Perugiaottobre2006–Doloreneuropaticorefrattario.− EuropeanFederationoftheNeurologicalSocieties−GlasgowSettembre2006

o Focusedworkshop:Skinbiopsy:anewwindowintotheperipheralnervoussystem.o Teachingcourse:Painfulneuropathies.

− UniversitàdiCatania,DipartimentodiEndocrinologia-maggio2006:Neuropatiadiabetica:patogenesi,diagnosi,terapie

− NeuroscienzeeDolore - PeschieraDelGarda (VR)27ottobre2006:La SindromedelleGambeSenzaRiposo

2005− UniversitàdiPadova,ClinicaNeurologica,Padova14febbraio2005−Neuropatiesensitive− XXXVICongressodellaSocietàItalianadiNeurologia,CernobbioOttobre2005−ClinicaeSemiologia

delleneuropatiesensitive.− UniversitàdiFerrara,maggio2005−Labiopsiacutaneanelladiagnosidelleneuropatieperiferiche.2003− King’sCollegeNeuromuscularDiseaseAnnualSymposium,DepartmentofNeurosciences,University

ofLondon,Novembre2003−Theuseofskinbiopsyinthediagnosisofperipheralneuropathies.− JohnsHopkinsUniversity,DptofNeuroscienceandNeurology,Baltimore−Oct,102003-Skinbiopsy

inPeripheralNeuropathies.− UniversitàdiFerrara.WorkshopdiNeuroimmunologia,settembre2003−Biopsiacutanea:Applicazioni

eProspettive2002− VIIcongressodelGruppoItalianodiStudiodelSistemaNervosoPeriferico,AscoliPicenoaprile2002−

Biopsiacutanea-Contributodiagnosticonelleneuropatiedolorose.

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5. DonedduPE,BianchiE,CocitoD,ManganelliF,FazioR,FilostoM,MazzeoA,CosentinoG,CorteseA,JannS,ClericiAM,AntoniniG,SicilianoG,LuigettiM,MarfiaGA,BrianiC,LauriaG,RossoT,CavalettiG,CarpoM,BenedettiL,BeghiE,LiberatoreG,SantoroL,PeciE,TronciS,PiccinelliSC,ToscanoA,PiccoloL,VerrengiaEP,LeonardiL,SchirinziE,MataluniG,RuizM,DacciP,Nobile-OrazioE;ItalianCIDPDatabaseStudyGroup.RiskfactorsforCIDP:antecedentevents,lifestyleanddietaryhabits.DatafromtheItalianCIDPdatabase.EurJNeurol.2019Jul20.doi:10.1111/ene.14044

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59. Vohra B, Estacion M, Hoeijmakers J, Faber CG, Merkies ISJ, Lauria G, Black JA, Waxman SG. Ca2+toxicity due to reverseNa+-Ca2+exchange contributes todegenerationof neurites ofDRGneuronsinducedbyaneuropathy-associatedNav1.7mutation.JNeurophysiol2015;114(3):1554-64.

60. Lauria G, Dacci P, Lombardi R, Cazzato D, Porretta-Serapiglia C, TaianaM, Sassone J, Dalla Bella E,Rinaldo S, Lettieri C, Eleopra R, Devigili G. Side and time variability of intraepidermal nerve fiberdensity.Neurology.2015Jun9;84(23):2368-71.

61. Tramacere I, Dalla Bella E, Chiò A,Mora G, Filippini G, Lauria G on behalf of the EPOS Trial StudyGroup. The MITOS system predicts long-term survival in amyotrophic lateral sclerosis. J NeurolNeurosurgPsychiatry2015Nov;86(11):1180-5.

62. DraakTH,PruppersMH,vanNesSI,VanhoutteEK,BakkersM,GorsonKC,VanderPolWL,NotermansNC,Nobile-OrazioE,LégerJM,VandenBerghPY,LauriaG,BrilV,KatzbergH,LunnMP,PougetJ,vanderKooiAJ,vandenBergLH,vanDoornPA,CornblathDR,HahnAF,FaberCG,MerkiesIS;PeriNomS

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63. VanhoutteEK,PDraakTH,GorsonKC, vanNes SI,Hoeijmakers JG,VanderPolWL,NotermansNC,Nobile-OrazioE,LégerJM,VandenBerghPY,LauriaG,BrilV,KatzbergH,LunnMP,PougetJ,vanderKooiAJ,HahnAF,vanDoornPA,CornblathDR,vandenBergLH,FaberCG,MerkiesIS;PeriNomSstudygroup. Impairment measures versus inflammatory-RODS in GBS and CIDP: A responsivenesscomparison.JPeripherNervSyst.2015Sep;20(3):289-95

64. DraakTH,VanhoutteEK,vanNesSI,GorsonKC,VanderPolWL,NotermansNC,Nobile-OrazioE,LégerJM,VandenBerghPY,LauriaG,BrilV,KatzbergH,LunnMP,PougetJ,vanderKooiAJ,HahnAF,vandenBergLH,vanDoornPA,CornblathDR,FaberCG,MerkiesIS.ComparingtheNISvsMRCandINCATsensoryscalethroughRaschanalyses.JPeripherNervSyst.2015Sep;20(3):277-88.

65. VanhoutteEK,FaberCG,vanNesSI,CatsEA,VanderPolWL,GorsonKC,vanDoornPA,CornblathDR,vandenBergLH,MerkiesIS;PeriNomSStudyGroup.Rasch-builtOverallDisabilityScaleforMultifocalmotorneuropathy(MMN-RODS©).JPeripherNervSyst.2015Sep;20(3):296-305.

66. PruppersMH,DraakTH,VanhoutteEK,VanderPolWL,GorsonKC,LégerJM,Nobile-OrazioE,LewisRA, van den Berg LH, Faber CG, Merkies IS; PeriNomS study group. Outcome measures in MMNrevisited:furtherimprovementneeded.JPeripherNervSyst.2015Sep;20(3):306-18.

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68. ImbriciP,MaggiL,MangiatordiG,DinardoMM,AltamuraC,BrugnoniR,AlbergaD,LauriaG,RicciG,SicilianoG,MicheliR,AnnicchiaricoG, LattanziG,NicolottiO,Morandi L,BernasconiP,Desaphy JF,Mantegazza R, Conte Camerino D. ClC-1 mutations in myotonia congenita patients: insights intomoleculargatingmechanismsandgenotype-phenotypecorrelation.JPhysiol2015;593(18):4181-4199

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70. HanC,YangY,deGreefBTA,HoeijmakersJGJ,GerritsMM,VerhammeC,QuJ,LauriaG,MerkiesISJ,FaberCG,Dib-HajjSD,WaxmanSG,onbehalfofthePROPANEStudyGroup.ThedomainIIS4-S5linkerinNav1.9: amissensemutation enhances activation, impairs fast-inactivation, and produces humanpainfulneuropathy.NeuromolecularMed.2015Jun;17(2):158-69.

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72. PensatoV,TilocaC,CorradoL,BertolinC,SardoneV,DelBoR,CaliniD,MandrioliJ,LauriaG,MazziniL,QuerinG,CeroniM,CantelloR,CortiS,CastellottiB,SoldàG,DugaS,ComiGP,CeredaC,SorarùG,D'AlfonsoS,TaroniF,ShawCE,LandersJE,TicozziN,RattiA,GelleraC,SilaniV.TUBA4AgeneanalysisinalargecohortofItalianpatientswithsporadicamyotrophiclateralsclerosis:identificationofnovelmutations.JNeurol2015;262(5):1376-8.

73. Rigamonti A, Lauria G, Mantero V, Piamarta F, Parolin M, Salmaggi A. A case of papilloedemaassociatedwithChiariImalformation.JNeurolSci.2015;353(1-2):183-4.

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76. Othman A, Bianchi R, Alecu I, Wei Y, Porretta-Serapiglia C, Lombardi R, Chiorazzi A, Meregalli C,Oggioni N, Cavaletti G, Lauria G, von Eckardstein A, Hornemann T. Lowering Plasma 1-DeoxysphingolipidsImprovesNeuropathyinDiabeticRats.Diabetes2015;64(3):1035-45

77. TaianaMM, Lombardi R, Porretta-Serapiglia C, Ciusani E, Oggioni N, Sassone J, Bianchi R, Lauria G.NeutralizationofSchwanncell-secretedVEGFisprotectivetoinvitroandinvivoexperimentaldiabeticneuropathy.PLoSOne2014Sep30;9(9):e108403.doi:10.1371/journal.pone.0108403

78. WaxmanSG,MerkiesISJ,GerritsMM,Dib-HajjSD,LauriaG,CoxJJ,WoodJN,WoodsCG,DrenthJPH,Faber CG. Sodium channel genes in pain-related disorders: review of phenotype-genotyperelationshipsandrecommendationsonclinicaluse.LancetNeurol2014;13(11):1152-60

79. SmithBN,TicozziN,FalliniC,GkaziAS,ToppS,KennaKP,ScotterEL,KostJ,KeagleP,MillerJW,CaliniD,VanceC,DanielsonEW,TroakesC,TilocaC,Al-SarrajS,LewisEA,KingA,ColombritaC,PensatoV,CastellottiB,deBellerocheJ,BaasF,TenAsbroekAL,SappPC,McKenna-YasekD,McLaughlinRL,PolakM, Asress S, Esteban-Pérez J, Muñoz-Blanco JL, SimpsonM; SLAGEN Consortium, van RheenenW,Diekstra FP, Lauria G, Duga S, Corti S, Cereda C, Corrado L, Sorarù G, Morrison KE, Williams KL,NicholsonGA,BlairIP,DionPA,LeblondCS,RouleauGA,HardimanO,VeldinkJH,vandenBergLH,Al-ChalabiA,PallH,ShawPJ,TurnerMR,TalbotK,TaroniF,García-RedondoA,WuZ,GlassJD,GelleraC,Ratti A, Brown RH Jr, Silani V, Shaw CE, Landers JE; SLAGEN Consortium. Exome-wide Rare VariantAnalysisIdentifiesTUBA4AMutationsAssociatedwithFamilialALS.Neuron.2014Oct22;84(2):324-31.

80. RigamontiA,LauriaG,MelziP,ManteroV,VismaraD,RossiG,TettoA,SalmaggiA.AcaseofBing-Neelsyndromepresentingasspinalcordcompression.JNeurolSci2014;346(1-2):345-7

81. DraakTH.P,VanhoutteEK, vanNes SI,GorsonKC,VanderPolWL,NotermansNC,Nobile-Orazio E,LégerJM,.VandenBerghPYK,LauriaG,BrilV,KatzbergH,LunnMPT,PougetJ,vanderKooiAJ,HahnAF,vanDoornPA,CornblathDR,vandenBergLH,FaberCG,Merkies ISJ,onbehalfofthePeriNomSstudy group. Changing outcome in inflammatory neuropathies: Rasch–comparative responsiveness.Neurology2014;83(23):2124-32

82. DallaTorreC,LessiF,CavallaroT,ScarlatoM,FerrariS,CampagnoloM,LucchettaM,CabriniI,MorbinM, Lauria G, Adami F, Manfredi AA, Briani C. Pentraxin-3 and VEGF in POEMS syndrome: a 2-yearlongitudinalstudy.JNeuroimmunology2014;277(1-2):189-192

83. DevigiliG,EleopraR,PierroT, LombardiR,RinaldoS, LettieriC,FaberCG,Merkies ISJ,WaxmanSG,LauriaG.Paroxysmalitchcausedbygain-of-functionNav1.7mutation.Pain.2014;155(9):1702-7.

84. FillaA, LauriaG.Guillain-Barré syndrome followingmeasles infection: case reportand reviewof theliterature.NeurolSci2014;35(12):2017-8.

85. Dalla Bella E, Rigamonti A, Mantero V, Morbin M, Saccucci S, Gellera C, Mora G, Lauria G.Heterozygous D90A-SOD1 mutation in a patient with facial onset sensory motor neuronopathy

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86. HuangJ,HanC,EstacionM,VasylyevD,GerritsMG,HoeijmakersJGJ,TyrrellL,LauriaG,FaberCG,Dib-Hajj SD,Merkies ISJ,Waxman SG, on behalf of the PROPANE StudyGroup. Gain-of-functionNaV1.9mutationsinpainfulneuropathy.Brain2014;137;1627–1642

87. LauriaG,ZieglerD,MalikR,MerkiesISJ,WaxmanSG,FaberCGonbehalfofthePROPANEStudygroup.The role of sodium channels in painful diabetic and idiopathic neuropathy. Curr Diab Rep2014;14(10):538-543.

88. PiscosquitoG,ReillyMM,SchenoneA,FabriziGM,CavallaroT,SantoroL,VitaG,QuattroneA,PaduaL,GemignaniF,VisioliF,LauràM,CalabreseD,HughesRA,RadiceD,SolariA,PareysonD;fortheCMT-TRIAAL&CMT-TRAUKGroup.IsoverworkweaknessrelevantinCharcot-Marie-Toothdisease?JNeurolNeurosurgPsychiatry.2014;85(12):1354-8

89. Nobbio L, Visigalli D, Radice D, Fiorina E, Solari A, Lauria G, Reilly MM, Santoro L, Schenone A,PareysonD,fortheCMT-TRIAALGroup.PMP22mRNAlevelsinCMT-TRIAALskinbiopsies:testingtheeffectivenessofaCMT1Abiomarker.Brain2014;137(Pt6):1614-20.

90. LauriaG,LombardiR.LettertotheEditor.Pain2014;155(6):1177-8.91. TzartosJS,ZisimopoulouP,RentzosM,KarandreasN,ZouvelouV,EvangelakouP,TsonisA,Thomaidis

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92. PupilloE,MessinaP,LogroscinoG,BeghiE;SLALOMGroup-MicheliA,RosettaniP,BaldiniD,BianchiG,RigamontiA,BonitoV,ChiveriL,GuidottiM,RezzonicoM,VidaleS,CorboM,LunettaC,MaestriE,CotelliMS,FilostoM,FilippiniG,LauriaG,MoraG,PapettiL,MorelliC,PeriniM,TavernelliF,PerroneP,GuaitaMC,TestaD,SasanelliF,GalbusseraA,TremolizzoL,FerrareseC,GalliA,VitelliE,PrelleA,RivaN,CeroniM,DelodoviciL,ClericiM,BonoG,BuzziP,PrevidiP,GuarneriG,AbruzziL,RiccardiT,LorussoL,MazziniL.Long-termsurvivalinamyotrophiclateralsclerosis:apopulation-basedstudy.AnnNeurol.2014;75(2):287-97.

93. BorsaniE,MajoranaA,CocchiMA,ContiG,BonadeoS,PadovaniA,LauriaG,BardelliniE,RezzaniR,Rodella LF. Epithelial expression of vanilloid and cannabinoid receptors: a potential role in burningmouthsyndromepathogenesis.HistolHistopathol.2014;29(4):523-533

94. BakkersM,FaberCG,HoeijmakersJG,LauriaG,MerkiesIS.Smallfibers,largeimpact:qualityoflifeinsmallfiberneuropathy.MuscleNerve2014;49(3):329-36

95. Rigamonti A, Lauria G, Grimod G, Bianchi G, Salmaggi A. Valproate induced hyperammonemicencephalopathysuccessfullytreatedwithlevocarnitine.JClinNeurosci.2014Apr;21(4):690-1

96. RigamontiA, LauriaG, Stanzani L,ManteroV,Andreetta F, SalmaggiA.Non-paraneoplastic voltage-gatedcalciumchannelsantibody-mediatedcerebellarataxiaresponsivetoIVIGtreatment.JNeurolSci.2014Jan15;336(1-2):169-70.

97. LatronicoN,FilostoM,FagoniN,GhezaL,GuarneriB,TodeschiniA,PadovaniA,LombardiR,LauriaG.Smallnervefiberpathologyincriticalillness.PLoSOne.2013Sep30;8(9):e75696.

98. DacciP,LessiF,DallaBellaE,MorbinM,BrianiC,LauriaG.IschemicstrokeasclinicalonsetofPOEMSsyndrome.JNeurol.2013;260:3178-81

99. Figliuzzi M, Bianchi R, Cavagnini C, Lombardi R, Porretta-Serapiglia C, Lauria G, Avezza F, Canta A,Carozzi V, Chiorazzi A, Marmiroli P, Meregalli C, Oggioni N, Sala B, Cavaletti G, Remuzzi A. Islettransplantation and insulin administration relieve long-term complications and rescue the residualendogenouspancreaticβcells.AmJPathol183:1527-38.

100. Vanhoutte EK, FaberCG,Merkies IS; PeriNomS study groupVandenBerghP, Bril V, vanDoornPA,FaberCG,GorsonK,HahnA,HughesRA,vanderKooiA,LauriaG,LegerJM,LewisR,LunnM,MerkiesIS,Nobile-Orazio E,NotermansNC,Querol L, van Schaik I, ZollingerD, ZittersteinA, van Engelen B,BarreiraAA,BennettD,vandenBergP,CornblathDR,DevigiliG,HaddenRD,IllaI,PaduaL,PougetJ,ReillyMM,deVisserM,vanNesSI,WalkD.196thENMCinternationalworkshop:Outcomemeasuresininflammatoryperipheralneuropathies8-10February2013,Naarden,TheNetherlands.NeuromusculDisord.2013Nov;23(11):924-33.

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103. IdiaquezJ,FadicR,VerdugoR, IdiaquezJF, IodiceV,LowDA,MathiasCJ,LombardiR,LauriaG.Pureautonomicfailurewithcoldinducedsweating.AutonNeurosci.2013;176(1-2):98-100

104. TilocaC,TicozziN,PensatoV,CorradoL,DelBoR,BertolinC,FenoglioC,GagliardiS,CaliniD,LauriaG,CastellottiB,BagarottiA,CortiS,GalimbertiD,CagninA,GabelliC,RanieriM,CeroniM,SicilianoG,MazziniL,CeredaC,ScarpiniE,SorarùG,ComiGP,D'AlfonsoS,GelleraC,RattiA,LandersJE,SilaniV;SLAGEN Consortium. Screening of the PFN1 gene in sporadic amyotrophic lateral sclerosis and infrontotemporaldementia.NeurobiolAging.2013May;34(5):1517.e9-1517.e10.

105. Rigamonti A, Lauria G, Prone V, Agostoni E. Mills’ syndrome: an Italian case and revision of theliterature.NeurolSci2013Feb;34(2):255-6

106. FaberCG*,LauriaG*,MerkiesISJ*,ChengX,HanC,AhnHS,PerssonAK,HoeijmakersJGJ,GerritsMM,PierroT,LombardiR,KapetisD,Dib-HajjSD,WaxmanSG(*co-firstauthors).Gain-of-functionNaV1.8mutationsinpainfulneuropathy.ProcNatlAcadSciUSA2012,Nov20;109(47):19444-9

107. DacciP,TaroniF,DallaBellaE,MilaniM,PareysonD,MorbinM,LauriaG.MyelinproteinzeroArg36Glymutation with very late onset and rapidly progressive painful neuropathy. J Periph Nerv Syst 2012Dec;17(4):422-5.

108. LauriaG,MerkiesISJ,FaberGC.Smallfibreneuropathy.CurrOpNeurol2012;25(5):542-9.109. Lauria G, Lombardi R. Small fiber neuropathy: is skin biopsy the Holy Grail? Curr Diab Rep

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113. LauriaG, LombardiR. Skinbiopsy inpainful and immune-mediatedneuropathies. JPeriphNerv Syst2012Dec;17Suppl3:38-45.

114. HanC,HoeijmakersJGJ,LiuS,GerritsMM,teMorscheRHM,LauriaG,Dib-HajjSD,DrenthJPH,FaberCG,MerkiesISJ,WaxmanSG.FunctionalprofilesofNav1.7variantsinDRGandSCGneuronscorrelatewithautonomicsymptomsinsmallfiberneuropathy.Brain2012;135(Pt9):2613-28

115. RigamontiA,LauriaG,StanzaniL,PiamartaF,AgostoniE.Acaseofmultifocalmotorneuropathywithconductionblockassociatedwithgastricandlungadenocarcinoma.JPeriphNervSyst2012;17(2):226-8.

116. Rigamonti A, Lauria G, Prone V, Fumagalli C, LongoniM, Balgera R, Agostoni E. Recurrent Horner'ssyndromeandpersistenttrigeminalartery.Neurologist,2012;18(6):406-408

117. GelleraC,TicozziN,PensatoV,NanettiL,CastucciA;CastellottiB,LauriaG,TaroniF,SilaniV,MariottiC.ATAXIN2CAG-repeatlengthinALSItalianpatients:riskfactororvariantphenotype?Implicationforgenetictestingandcounselling.NeurobiologyofAging2012;33(8):1847.e15-21

118. HoeijmakersJGJ,FaberCG,LauriaG.,MerkiesISJ,WaxmanSG.Smallfiberneuropathies:advancesindiagnosis,pathophysiologyandmanagement.NatureReviewsNeurology2012;8:369–379

119. HanC,Hoeijmakers JGJ,AhnHS,ZhaoP,ShahP,LauriaG,GerritsMM,MorscheRHM,Dib-HajjSD,DrenthJPH,FaberCG,MerkiesISJ,WaxmanSG.Nav1.7-relatedsmallfiberneuropathy:Impairedslow-inactivationandDRGneuronhyperexcitability.Neurology2012;78(21):1635-1643.

120. HoeijmakersJGJ,HanC,MerkiesISJ,MacalaLJ,LauriaG,GerritsMM,Dib-HajjDS,FaberCG,WaxmanS. Small nerve fibres, small hands and small feet: a new syndrome of pain, dysautonomia andacromesomeliainakindredwithanovelNaV1.7mutation.Brain2012;135;345–358

121. VanhoutteEK,CGFaber,vanNesSI, JacobsBC,vanDoornPA,vanKoningsveldR,CornblathDR,vanderKooiAJ,CatsEA,vandenBergLH,NotermansNC,vanderPolWL,HermansMCE,vanderBeekNAE, Gorson KC, EurelingsM, Engelsman J, Boot H,Meijer RJ, Lauria G, Tennant A,Merkies SIJ onbehalfofthePeriNomSStudyGroup.ModifyingtheMedicalResearchCouncilgradingsystemthroughRaschanalyses.Brain2012;135(Pt5):1639-1649.

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122. Chiò A, Borghero G, Restagno G,Mora G,Drepper C, Traynor BJ, SendtnerM, BrunettiM, Ossola I,CalvoA,PugliattiM,SotgiuMA,MurruMR,MarrosuMG,MarrosuF,MarinouK,Mandrioli J,SolaP,Caponnetto C,Mancardi G,Mandich P, La Bella V, Spataro R, Conte A,Monsurro`MR, Tedeschi G,PisanoF,BartolomeiI,SalviF,LauriaG,SimoneI,LogroscinoG,GambardellaA,QuattroneA,LunettaC, Volanti P, Zollino M, Penco S, Battistini S, The ITALSGEN consortium, Renton AE, Majounie E,Abramzon Y, Conforti FL, Giannini F, CorboM, Sabatelli M. Clinical characteristics of patients withfamilial amyotrophic lateral sclerosis carrying the pathogenic GGGGCC hexanucleotide repeatexpansionofC9ORF72.Brain2012:135;784–793

123. MariottiC,FancelluR,CaldarazzoS,NanettiL,DiBellaD,PlumariM,LauriaG,CappelliniMD,DucaL,SolariA,TaroniF.ErythropoietininFriedreichAtaxia:NoEffectonFrataxininaRandomizedControlledTrial.MovementDisorders2012;27(3):446-449

124. OthmanA,RüttiMF,ErnstD,SaelyCH,ReinP,DrexelH,Porretta-SerapigliaC,LauriaG,BianchiR,vonEckardsteinA,HornemannT.Plasmadeoxysphingolipids:anovelclassofbiomarkersforthemetabolicsyndrome?Diabetologia2012Feb;55(2):421-31.

125. Bianchi R, Cervellini I, Porretta-Serapiglia C, Oggioni N, Burkey B, Ghezzi P, Cavaletti G, Lauria G.Beneficial effects of PKF275-055, a novel, selective, and orally bioavailable, longacting dipeptidylpeptidase IV inhibitor in streptozotocin-induceddiabeticperipheralneuropathy. JPharmExpTherap2012;340(1):64-72

126. Faber CG,Hoeijmakers JGJ, ChengX,AhnH-S,HanC, Choi J-S, EstacionM, LauriaG, Vanhoutte EK,GerritsMM,Dib-Hajj S,Drenth JPH,Waxman SG,Merkies ISJ.Gain-of-functionNaV1.7mutations inidiopathicsmallnervefiberneuropathy.AnnNeurol2012;71:26–39

127. RutsL,vanDoornPA,LombardiR,HaasdijkED,PenzaP,TulenJH,HempelRJ,vandenMeirackerAH,Lauria G. Unmyelinated andmyelinated skin nerve damage in Guillain-Barré syndrome: correlationwithpainandrecovery.Pain2012;153(2):399-409

128. RistagnoG, Fumagalli F, Porretta-Serapiglia C,OrrùA, CassinaC, PesaresiM,Masson S,Villanova L,MerendinoA,VillanovaA,CervoL,LauriaG,LatiniR,BianchiR.Hydroxytyrosolattenuatesperipheralneuropathyinstreptozotocin-induceddiabetesinrats.JAgricFoodChem.2012;60(23):5859-65.

129. DelSorboF,BrancatiF,DeJoannaG,ValenteEM,LauriaG,AlbaneseA.Primaryfocalhyperhidrosisinanewfamilynotlinkedtoknownloci.Dermatology2011;223(4):335-42

130. EstacionM,HanC,ChoiJS,HoeijmakersJGJ,LauriaG,DrenthJPH,GerritsMM,Dib-HajjS,FaberCG,Merkies ISJ, Waxman SG. Intra- and interfamily Phenotypic Diversity in Pain Syndromes associatedwithaGain-of-FunctionVariantofNaV1.7.MolecPain2011;7:92-102

131. Lauria G, Cazzato D, Carla Porretta-Serapiglia C, Casanova-Molla J, TaianaM, Penza P, Lombardi P,FaberCG, ISJMerkies.Morphometryofdermalnerve fibers inhumanskin.Neurology.2011;77:242-249

132. Lauria G, Faber CG, ISJ Merkies. Morphometry of dermal nerve fibers in human skin. Neurology2011;77:9(letter)

133. Ruggenenti P, Lauria G, Iliev IP, Fassi A, Ilieva AP, Rota S, Chiurchiu C, Barlovic DP, Sghirlanzoni A,LombardiR,PenzaP,CavalettiG,PiattiML,FrigeniB,FilipponiM,RubisN,NorisG,MotterliniN,Ene-Iordache B, Gaspari F, Perna A, Zaletel J, Bossi A, Trevisan R, Remuzzi G, for the DEMAND StudyInvestigators. Effects of manidipine and delapril in hypertensive patients with type 2 diabetes: theDEMANDrandomizedclinicaltrialHypertension2011;58(5):776-783

134. PesaresiM,Giatti S, Cavaletti G, Abbiati F, CalabreseD, Lombardi R, Bianchi R, LauriaG, CarusoD,Garcia-Segurae LM, Melcangi RC. Sex-Dimorphic Effects Of Dehydroepiandrosterone In DiabeticNeuropathy.Neuroscience,2011;199:401-9.

135. Penza P, BricchiM, Scola A, Campanella A, Lauria G. Electroacupuncture is not effective in chronicpainfulneuropathies.PainMed.201112(12):1819-1823

136. LauriaG.Neuropathicpainanddiabetes: focusonmechanismsandpotential therapeutic strategies.HotTopicsinNeurologyandPsychiatry2011;10:7-12

137. MalikRA,VevesA,TesfayeS,SmithG,CameronN,ZochodneD,LauriaG.SmallFiberNeuropathy:RoleinthediagnosisofDiabeticSensorimotorPolyneuropathy.DiabetesMetabResRev2011;27:678–684.

138. León L, Casanova-Molla J, Lauria G, Valls-Solé J. The somatosensory blink reflex in upper and lowerbrainstemlesions.MuscleNerve2011;43(2):196-202.

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139. Rigamonti A, Lauria G, Piamarta F, Fiumani A, Agostoni E. Thymoma-associated myasthenia graviswithoutacetylcholinereceptorantibodies.JNeurolSci.2011;302(1-2):112-3

140. RigamontiA, LauriaG, LongoniM,Stanzani L,AgostoniE.Acute isolatedophthalmoplegiawithanti-GQ1bantibodies:acasereport.NeurolSci.2011Aug;32(4):681-2

141. PetersMJH,vanNesSI,Vanhoutte1EK,BakkersM,vanDoornPA,MerkiesISJ,FaberCGonbehalfofthePeriNomSStudygroup:RevisednormativevaluesforgripstrengthwiththeJamardynamometer.JPeriphNervSyst2011;16:47-50

142. PareysonD,ReillyMM,SchenoneA,FabriziGM,CavallaroT,SantoroL,VitaG,QuattroneA,PaduaL,GemignaniF,VisioliF,LauràM,RadiceD,CalabreseD,HughesRA,SolariA;CMT-TRIAAL;CMT-TRAUKgroups. Ascorbic acid in Charcot-Marie-Tooth disease type 1A (CMT-TRIAAL and CMT-TRAUK): adouble-blindrandomisedtrial.LancetNeurol.2011Apr;10(4):320-8.

143. Lauria G, Bakkers M, Schmitz C, Lombardi R, Penza P, Devigili G, Smith AG, Hsieh ST, Mellgren SI,Umapathi T, ZieglerD, Faber CG,Merkies ISJ. Intraepidermal nerve fiber density at the distal leg: aworldwidenormativereferencestudy.JPeriphNervSyst,2010;15:202-207

144. Dacci P, Dina G, Cerri F, Previtali SC, Lopez ID, Lauria G, Feltri ML, Bolino A, Comi G, Wrabetz L,QuattriniA.Footpadskinbiopsyinmousemodelsofhereditaryneuropathy.Glia.2010;58:2005–2016

145. BakonjaM,LauriaG.Takingapeekintopain,fromskintobrain.Pain.2010Dec;151(3):559-60.146. Marchesi C,MilaniM,MorbinM, CesaniM, Lauria G, Scaioli V, Piccolo G, Fabrizi GM, Cavallaro T,

Taroni F, PareysonD. Four novel cases of periaxin-related neuropathy and review of the literature.Neurology2010;75:1830–1838

147. Tesfaye S, BoultonAJ,Dyck PJ, FreemanR,HorowitzM, Kempler P, LauriaG,Malik RA, SpalloneV,VinikA,Bernardi L,Valensi P;onbehalfof theTorontoDiabeticNeuropathyExpertGroup.DiabeticNeuropathies: Update on Definitions, Diagnostic Criteria, Estimation of Severity, and Treatments.DiabetesCare.2010Oct;33(10):2285-2293

148. BakkersM,FaberCG,DrentM,HermansMC,vanNesSI,LauriaG,DeBaetsM,Merkies IS.Painandautonomic dysfunction in patients with sarcoidosis and small fibre neuropathy. J Neurol. 2010;257(12):2086-90

149. GhezziP,BernaudinM,BianchiR,BlomgrenK,BrinesM,CampanaW,CavalettiG,CeramiA,ChoppM,ColemanT,DigicayliogluM,EhrenreichH,ErbayraktarS,ErbayraktarZ,GassmannM,GencS,GokmenN, Grasso G, Juul S, Lipton SA, Hand CC, Latini R, Lauria G, LeistM, Newton SS, Petit E, Probert L,SfacteriaA,SirenAL,TalanM,ThiemermannC,WestenbrinkD,YaqoobM,ZhuC.Erythropoietin:notjustabouterythropoiesis.Lancet.2010Jun19;375(9732):2142.

150. LauriaG,HsiehST,JohanssonO,KennedyWR,LegerJM,MellgrenSI,NolanoM,MerkiesISJ,PolydefkisM,SmithAG,SommerC,Valls-SoléJ.EuropeanFederationofNeurologicalSocieties/PeripheralNerveSocietyGuidelineontheUseofSkinBiopsyintheDiagnosisofSmallFibreNeuropathy.EurJNeurol,2010Jul;17(7):903-912;e44-49

151. LauriaG,HsiehST,JohanssonO,KennedyWR,LegerJM,MellgrenSI,NolanoM,MerkiesISJ,PolydefkisM,SmithAG,SommerC,Valls-SoléJ.EuropeanFederationofNeurologicalSocieties/PeripheralNerveSocietyGuidelineontheUseofSkinBiopsyintheDiagnosisofSmallFibreNeuropathy.JPeriphNervSyst2010;15(2):79-92.

152. PenzaP,MajoranaA, LombardiR, Camozzi F, BonadeoS, Sapelli P, LauriaG. “Burning Tongue” and“BurningTip”:TheDiagnosticChallengeofBurningMouthSyndrome.ClinJPain,2010;26(6):528-32.

153. CervelliniI,BelloE,FrapolliR,Porretta-SerapigliaC,OggioniN,CantaA,LombardiR,CamozziF,RoglioI,Melcangi RC,D’IncalciM, LauriaG,Ghezzi P, CavalettiG, Bianchi R. Theneuroprotective effect oferythropoietinindocetaxel-inducedperipheralneuropathyisexertedwithnoreductionofantitumouractivityin13762adenocarcinoma-bearingrats.NeurotoxRes.2010;18(2):151-160

154. Nanetti L, Lauria G, Scaioli V, Marchesi C, Salsano E, Lombardi R, Pareyson D. Slowly progressivesensoryhemisyndrome:unusualpresentationofparaneoplastic sensoryneuronopathy JPeriphNervSyst,2010Mar;15(1):73-4.

155. RigamontiA,BassoF,StanzaniL,AgostoniE,LauriaG.Guillain-Barrésyndromemimickingbraindeath.JPeriphNervSyst2009;14(4):316-9.

156. vanNes SI, Vanhoutte EK, Faber CG,GarssenM, vanDoorn PA,Merkies IS; PeriNomS StudyGroup(BennettD,vandenBergLH,VandenBerghPY,CornblathDR,DalakasM,DevigiliG,vanDoornPA,FaberCG,GorsonKC,HaddenRD,HahnAF,HartungHP,HughesRA,LauriaG,LégerJM,LewisRA,Lunn

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MP, Merkies IS, Nobile-Orazio E, Notermans NC, Padua L, Reilly MM, Smith B). Improving fatigueassessment in immune-mediated neuropathies: the modified Rasch-built fatigue severity scale. JPeripherNervSyst.2009;14(4):268-78.

157. Remuzzi A, Cornolti R, Bianchi R, Figliuzzi M, Porretta-Serapiglia C, Oggioni N, Carozzi V, Crippa L,AvezzaF,FiordalisoF,SalioM,LauriaG,LombardiR,CavalettiG.Regressionofdiabeticcomplicationsbyislettransplantationintherat.Diabetologia2009;52:2653–2661

158. GiattiS,PesaresiM,CavalettiG,BianchiR,CarozziV,LombardiR,MaschiO,LauriaG,Garcia-SeguraLM,CarusoD,Melcangi RC.Neuroprotective effects of a ligandof translocator protein-18kda (RO5-4864)inexperimentaldiabeticneuropathy.Neuroscience2009;164(2):520-9.

159. LauriaG,CampanellaA,FilippiniG,MartiniA,PenzaP,MaggiL,AntozziC,CianoC,BerettaP,CaldiroliD, Ghelma F, FerraraG, Ghezzi P,Mantegazza R. Erythropoietin in Amyotrophic Lateral Sclerosis: Apilot, randomised,double-blind,placebo-controlled studyof safetyand tolerability.Amyotrophic LatSclerosis2009;10(5-6):410-5

160. BakkersM,MerkiesISJ,LauriaG,DevigiliG,PenzaP,LombardiR,HermansMCE,vanNesSI,DeBaetsM,FaberCG. Intra-epidermalnerve fiberdensitynormativevaluesand itsapplication insarcoidosis.Neurology2009;73:1142–1148

161. ChiorazziA,NicoliniG,CantaA,OggioniN,RigolioR,CossaG,LombardiR,RoglioI,CervelliniI,LauriaG,MelcangiRC,BianchiR,CrippaD,CavalettiG.ExperimentalepothiloneBneurotoxicity:resultsofinvitroandinvivostudies.NeurobiolDis2009;35(2):270-7

162. CantaA, Chiorazzi A,Meregalli C, Carozzi V,OggioniN, LauriaG, Bianchi R,NicoraMF, Cavaletti G.Continuous buprenorphine delivery effect in streptozotocine-induced painful diabetic neuropathy inrats.JPain2009;10(9):961-8.

163. Rigamonti A, Lauria G, Balgera R, Agostoni E. Subacute inflammatory polyradiculopathy associatedwithSjögren’ssyndrome.MuscleNerve.200939(6):855-7.

164. CavalettiG,CornblathDR,PostmaTJ,MerkiesIS,ArgyriouA,BoogerdW,BrianiC,BrunaJ,FaberCG,Grisold W, Heimans JJ, Kalofonos H, Krarup-Hansen A, Koeppen S, Lauria G, Leandri M, Mielke S,Nobile-OrazioE,PaceA,PaduaL,PlasmatiR,PsimarasD,RosT,SchenoneA,StragliottoG,GalimbertiS, Valsecchi MG (CI-PERINOMS Study Group) CI-PERINOMS: chemotherapy-induced peripheralneuropathyoutcomemeasuresstudy.JPeriphNervSyst2009;14(2):69-71.

165. Roglio I, Bianchi R, Camozzi F, Carozzi V, Cervellini I, Crippa D, Lauria G, Cavaletti G, Melcangi RC.Docetaxel-induced peripheral neuropathy: protective effects of dihydroprogesterone andprogesteroneinanexperimentalmodel.JPeripherNervSyst.2009Mar;14(1):36-44.

166. PenzaP,LombardiR,CamozziF,CianoC,LauriaG.Painfulneuropathy insubclinicalhypothyroidism:clinical and neuropathological recovery after hormone replacement therapy. Neurol Sci. 2009Apr;30(2):149-51.

167. (RMC Trial Group) Mahdi-Rogers M, Rutterford C, Hughes RA, Léger JM, Nobile-Orazio E, Van denBerghP,vanDoornP,vanSchaik IN,HughesRA,HaddenRD,ChoyE,ReillyM,WinerJ,EversE,vanSchaikIN,vanDoornPA,LégerJM,Nobile-OrazioE,VandenBerghP,CréangeA,GueguenA,UzenotD,LégerJM,BehinA,NicolasG,PautotV,UnciniA,ManzoliC,LauriaG,PareysonD,Nobile-OrazioE,CasellatoC,SabatelliM,ConteA,LuigettiM,BrianiC,LucchettaM,SchenoneA,BenedettiL,FiorinaE,van Doorn PA, Brusse E, van Schaik IN, van der Kooi AJ, Hughes RA, Hadden RD,Mahdi-RogersM,GuiloffRJ,RakowiczWP,LeckyBR,DouganCF,MarshallD,Winer J,DaviesN,BusbyM,LansburyA,OverellJ,WillisonHJ,RajaballyYA,KendallB,ReillyM,GowD,NixonJ,KulkarniO,KatifiH,HammansS,GibsonA,McDermottC,CornblathDR,ChaudryV.Randomisedcontrolledtrialofmethotrexateforchronic inflammatory demyelinating polyradiculoneuropathy (RMC trial): a pilot, multicentre study.LancetNeurol.2009Feb;8(2):158-64.

168. EnglandJD,GronsethGS,FranklinG,CarterGT,KinsellaLJ,CohenJA,AsburyAK,SzigetiK,LupskiJR,Latov N, Lewis RA, Low PA, FisherMA, Herrmann D, Howard JF, Lauria G,Miller RG, PolydefkisM,Sumner AJ; American Academy of Neurology; American Association of Neuromuscular andElectrodiagnosticMedicine;AmericanAcademyofPhysicalMedicineandRehabilitation.Evaluationofdistal symmetric polyneuropathy: The role of laboratory and genetic testing (an evidence-basedreview).MuscleNerve.2009;39(1):116-25

169. EnglandJD,GronsethGS,FranklinG,CarterGT,KinsellaLJ,CohenJA,AsburyAK,SzigetiK,LupskiJR,Latov N, Lewis RA, Low PA, FisherMA, Herrmann D, Howard JF, Lauria G,Miller RG, PolydefkisM,

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Sumner AJ; American Academy of Neurology; American Association of Neuromuscular andElectrodiagnosticMedicine;AmericanAcademyofPhysicalMedicineandRehabilitation.Evaluationofdistal symmetric polyneuropathy: The role of laboratory and genetic testing (an evidence-basedreview).PMR.2009Jan;1(1):5-13.

170. EnglandJD,GronsethGS,FranklinG,CarterGT,KinsellaLJ,CohenJA,AsburyAK,SzigetiK,LupskiJR,Latov N, Lewis RA, Low PA, FisherMA, Herrmann D, Howard JF, Lauria G,Miller RG, PolydefkisM,Sumner AJ; American Academy of Neurology; American Association of Neuromuscular andElectrodiagnosticMedicine;AmericanAcademyofPhysicalMedicineandRehabilitation.Evaluationofdistal symmetric polyneuropathy: The role of autonomic testing, nerve biopsy, and skin biopsy (anevidence-basedreview).MuscleNerve.2009;39(1):106-15.

171. EnglandJD,GronsethGS,FranklinG,CarterGT,KinsellaLJ,CohenJA,AsburyAK,SzigetiK,LupskiJR,Latov N, Lewis RA, Low PA, FisherMA, Herrmann D, Howard JF, Lauria G,Miller RG, PolydefkisM,Sumner AJ; American Academy of Neurology; American Association of Neuromuscular andElectrodiagnosticMedicine;AmericanAcademyofPhysicalMedicineandRehabilitation.Evaluationofdistal symmetric polyneuropathy: The role of autonomic testing, nerve biopsy, and skin biopsy (anevidence-basedreview).PMR.2009Jan;1(1):14-22.

172. EnglandJD,GronsethGS,FranklinG,CarterGT,KinsellaLJ,CohenJA,AsburyAK,SzigetiK,LupskiJR,Latov N, Lewis RA, Low PA, FisherMA, Herrmann D, Howard JF, Lauria G,Miller RG, PolydefkisM,Sumner AJ. Practice Parameter: The evaluation of distal symmetric polyneuropathy: the role oflaboratory and genetic testing (an evidence-based review). Report of the American Academy ofNeurology, the American Association of Neuromuscular and Electrodiagnostic Medicine, and theAmericanAcademyofPhysicalMedicineandRehabilitation.Neurology.2009Jan13;72(2):185-92.

173. EnglandJD,GronsethGS,FranklinG,CarterGT,KinsellaLJ,CohenJA,AsburyAK,SzigetiK,LupskiJR,Latov N, Lewis RA, Low PA, FisherMA, Herrmann D, Howard JF, Lauria G,Miller RG, PolydefkisM,Sumner AJ. Practice Parameter: The evaluation of distal symmetric polyneuropathy: the role ofautonomictesting,nervebiopsy,andskinbiopsy(anevidence-basedreview)ReportoftheAmericanAcademyofNeurology, theAmericanAssociationofNeuromuscularandElectrodiagnosticMedicine,and the American Academy of Physical Medicine and Rehabilitation. Neurology. 2009 Jan13;72(2):177-84

174. LauriaG, Lombardi R, Camozzi F, Devigili G. Skin biopsy for the diagnosis of peripheral neuropathy.Histopathology.2009Feb;54(3):273-85.

175. Penza P, Campanella A, Martini A, Melli G, Lombardi R, Camozzi F, Devigili G, Lauria G. Short andintermediate-term efficacy of buprenorphine TDS in chronic painful neuropathies. J Periph NervSystem,2008;13(4):283-8.

176. Melli G, Taiana M, Camozzi F, Triolo D, Podini P, Quattrini A, Taroni F, Lauria G. Alpha-lipoic acidprevents mitochondrial damage and neurotoxicity in experimental chemotherapy neuropathy. ExpNeurol.2008;214(2):276-84

177. Devigili G, Tugnoli V, Penza P, Camozzi F, Lombardi R, Melli G, Broglio L, Granieri E, Lauria G. Thediagnostic criteria for small fibreneuropathy: fromsymptoms toneuropathology.Brain2008;131(Pt7):1912-25

178. vanNesSI,FaberCG,HamersRM,HarschnitzO,BakkersM,HermansMC,MeijerRJ,vanDoornPA,MerkiesIS;BennettD,vandenBergLH,VandenBerghPY,CornblathDR,DalakaSM,vanDoornPA,FaberCG,GorsonKC,HaddenRD,HahnAF,HughesRA,LauriaG,LégerJM,LewisRA,LunnPT,MerkiesIS,Nobile-OrazioE,NotermanSNC,PaduaL,ReillyMM.Revisingtwo-pointdiscriminationassessmentin normal aging and in patients with polyneuropathies. J Neurol Neurosurg Psychiatry. 2008Jul;79(7):832-4.

179. Magnaghi,V,BallabioM,CamozziF,ColleoniM,ConsoliA,GassmannM,LauriaG,MottaM,ProcacciP,TrovatoAE,BettlerB.Alteredperipheralmyelinationandpainperception inmice lackingGABA-breceptors.MolCellNeurosci2008;37:599–609

180. Focosi D, Kast RE,Maggi F, LauriaG, Ceccherini-Nelli L, PetriniM. 5-HT2a inhibitors for progressivemultifocalleukoencephalopathy:olddrugsforanolddisease.JInfectDis2008;197(2):328

181. SolariA, LauràM, SalsanoE,RadiceD,PareysonD, (CMT-TRIAALStudyGroup) SalsanoE,Marelli C,Scaioli V, Ciano C, Rimoldi M, Rizzetto E, Camozzi F, Schenone A, GrandisM, Narciso E, Nobbio L,BenedettiL,RizzutoN,FabriziGM,CavallaroT,BertolasiL,CasanoA,ManganelliF,PisciottaC,Nolano

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M,VitaG,MazzeoA,DiLeoR,GirlandaP,MajoranaG,AguennouzM,CiranniA,LanzanoN,QuattroneA,ValentinoP,NisticòR,PirritanoD,ClodomiroA,CaninoM,PazzagliaC,MignognaT,GemignaniF,BrindaniF,VitettaF,VisioliF,BoganiP,HughesRA, VisioliF,MancardiGL,CavalettiG,GalimbertiS,RadiceD, CalabreseD, FerrariG,Visioli F, RimoldiM, Santoro L, Padua L, SeredaMW, SchenoneA,LauriaG.ReliabilityofclinicaloutcomemeasuresinCharcot-Marie-Toothdisease.NeuromusculDisord.2008;18(1):19-26.

182. Roglio I, Giatti S, Pesaresi M, Bianchi R, Cavaletti G, Lauria G, Garcia-Segura LM, Melcangi RC.Neuroactivesteroidsandperipheralneuropathy.BrainResReviews2008;57(2):460-9.

183. Lauria G, Lombardi R. Skin biopsy: a new tool for diagnosing peripheral neuropathy. Br Med J2007;334(7604):1159-1162

184. LauriaG,DevigiliG.Skinbiopsyasadiagnostictoolinperipheralneuropathies.NatureClinicalPracticeNeurology2007,Oct;3(10):546-57.

185. Sommer C, Lauria G. Skin biopsy: a new diagnostic tool for autonomic dysfunctions in Parkinson'sdisease?LancetNeurology2007;6:849

186. Sommer C, Lauria G. The use of skin biopsy in the management of peripheral neuropathy. LancetNeurology2007;6:632-642.

187. LauriaG.Recentdevelopments in themanagementofperipheral neuropathyusing skinbiopsy.RevNeurologique2007;163:1266-1270

188. MarucciG,Morandi L, Bartolomei I, Salvi F, PessionA, Righi A, LauriaG, FoschiniMP.AmyotrophiclateralsclerosiswithmutationoftheCu/Znsuperoxidedismutasegene(SOD1)inapatientwithDownsyndrome.NeuromusculDisord.2007;17(9-10):673-6.

189. RigamontiA,MagiS,VenturiniE,MorandiL,CianoC,LauriaG.Celiacdiseasepresentingwithmotorneuropathy:effectofglutenfree-diet.MuscleNerve2007;35(5):675-677

190. Roglio I,BianchiR,Giatti S,CavalettiG,CarusoD, Scurati S,CrippaD,Garcia-Segura LM,Camozzi F,LauriaG,MelcangiRC.Testosteronederivativesareneuroprotectiveagents inexperimentaldiabeticneuropathy.CellMolLifeSci2007;64(9):1158-68.

191. BianchiR,GiardiniA,Rodriguez-MenendezV,OggioniN,CantaA,ColomboT,DeMicheleG,MartoneS, Sfacteria A, Piedemonte G, Grasso G, Beccaglia P, Ghezzi P, D'Incalci M, Lauria G, Cavaletti G.Cisplatin-inducedperipheralneuropathy:neuroprotectionbyerythropoietinwithoutaffectingtumourgrowth.EurJCancer2007;43:710-717.

192. LeonelliE,BianchiR,CavalettiG,CarusoD,CrippaD,Garcia-SeguraLM,LauriaG,MagnaghiV,RoglioI,MelcangiRC.Progesteroneanditsderivativesareneuroprotectiveagentsinexperimentaldiabeticneuropathy:biochemicalandfunctionalanalyses.Neuroscience2007;144:1293-1304.

193. RestivoDA,Marchese-RagonaR,LauriaG,SquatritoS,GulloD,VigneriR.Botulinumtoxintreatmentfororopharyngealdysphagiaassociatedwithdiabeticneuropathy.DiabetesCare2006;29:2650-2653.

194. LauriaG,MorbinM,LombardiR,CapobiancoR,CamozziF,PareysonD,ManconiM,GeppettiP.Expressionofcapsaicinreceptorimmunoreactivityinhumanperipheralnervoussystemandinpainfulneuropathies.JPeriphNervSyst2006,11:262–271

195. BianchiR,BrinesM,LauriaG,SavinoC,GiardiniA,NicoliniG,Rodriguez-MenendezV,OggioniN,CantaA, Penza P, Lombardi R, Minoia C, Ronchi A, Cerami A, Ghezzi P, Cavaletti G. Protective effect oferythropoietin and of its carbamylated derivative in experimental cisplatin peripheral neurotoxicity.ClinCancerRes2006;12:2607-2612.

196. Merkies IS, Lauria G. 131st ENMC international workshop: selection of outcome measures forperipheral neuropathy clinical trials 10-12December2004,Naarden, TheNetherlands.NeuromusculDisord.2006;16:149-156.

197. SghirlanzoniA,PareysonD,LauriaG.Sensoryneurondiseases.LancetNeurology2005;4:349-361198. Lombardi R, Erne B, Lauria G, Pareyson D, Borgna M, Morbin M, Arnold A, Czaplinski A, Fuhr P,

Schaeren-Wiemers N, Steck AJ. IgM deposits on skin nerves in anti–myelin-associated glycoproteinneuropathy.AnnNeurol2005;57:180–187

199. LauriaG,MajoranaA, BorgnaM, Lombardi R, Penza P, Padovani A, Sapelli P. Trigeminal small-fibersensoryneuropathycausesburningmouthsyndrome.Pain2005;115:332–337.

200. LauriaG.Skinbiopsyinthediagnosisofperipheralneuropathies.PracticalNeurology2005;5:92-99.

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201. LauriaG,CornblathDR,JohanssonO,McArthur,S.I.Mellgren,M.Nolano,N.Rosenberg,C.Sommer.EFNS Guidelines on the use of skin biopsy in the diagnosis of peripheral neuropathy. Eur J Neurol2005;12:747–758

202. LauriaG,LombardiR,BorgnaM,PenzaP,BianchiR,SavinoC,CantaA,NicoliniG,MarmiroliP,Cavaletti

G.Intraepidermalnervefiberdensityinratfootpad:neuropathologic-neurophysiologiccorrelation.JPeriphNervSyst2005;10:199–205.

203. LauriaG.Smallfibreneuropathy.CurrOpinNeurol2005;18:591–597204. BroglioL,LauriaG.Worseningafterrituximabtreatmentinanti-MAGneuropathy.MuscleNerve2005;

32:378-9205. LauriaG.Semeiologiaeclinicadelleneuropatiesensitive.NeurolSci2005;26:S301-S304.206. Lauria G, Borgna M, Morbin M, Lombardi R, Mazzoleni G, Sghirlanzoni A, Pareyson D. Tubule and

neurofilamentimmunoreactivityinhumanhairyskin:markersforintraepidermalnervefibers.MuscleNerve2004;30:310-316.

207. BianchiR,BuyukakilliB,BrinesM,SavinoC,CavalettiG,OggioniN,LauriaG,BorgnaM,LombardiR,CimenB,ComelekogluU,KanikA,TatarogluC,CeramiA,GhezziP.Erythropoietinbothprotectsfromandreversesexperimentaldiabeticneuropathy.ProcNatlAcadSciUSA2004;10:823-828

208. LauriaG,LombardiR,BorgnaM.L'innervazionedellacutenell'uomo:daPaulLangerhansalleattualiprocedurediagnostiche.NeurolSci2004;25:S419-S422.

209. LauriaG,MorbinM,LombardiR,BorgnaM,MazzoleniG,SghirlanzoniA,PareysonD.Axonalswellingspredict thedegenerationofepidermalnerve fibers inpainfulneuropathies.Neurology2003;61:631-636

210. LauriaG,PareysonD,PitzoluMG,BazzigaluppiE.Excellentresponsetosteroidtreatmentinanti-GADcerebellarataxia.LancetNeurology2003;2:634-635

211. Lauria G, Pareyson D, Sghirlanzoni A. Neurophysiological diagnosis of acquired sensoryganglionopathy.EurNeurol2003;50:146-152

212. Pareyson D, Testa D, Morbin M, Erbetta A, Ciano C, Lauria G, Milani M, Taroni F. Does CMT1AhomozygositycausemoreseverediseasewithroothypertrophyandhigherCSFproteins?Neurology2003;60:1721-1722.

213. Pareyson D, Sghirlanzoni A, Lauria G. Algoritmo diagnostico: dal sintomo alla causa. Polineuropatiesensitive.NeurolSci2003;24:S677-S680.

214. PareysonD,ScaioliV,CianoC,LauriaG,SghirlanzoniA,TaroniF.NeuropatiediCharcot-Marie-Tooth:rivisitazionedellaneurofisiopatologianell’eradellageneticamolecolare.NeurolSci2002;23:S461-S466

215. LauriaG,PareysonD,SghirlanzoniA.Sensoryganglionopathies:causesandneuroradiologicalfindings.NEnglJMed2002;346(13):1029-1030.

216. LauriaG,SghirlanzoniA,LombardiR,PareysonD.Epidermalinnervationinsensoryganglionopathies–Clinicalandneurophysiologicalcorrelations.MuscleNerve2001;24:1034-1039.

217. Lauria G, Erbetta A, Pareyson D, Sghirlanzoni A. Parenchymatous neurosyphilis. Neurol Sci2001;22:281-282.

218. Pareyson D, Lauria G, Sghirlanzoni A. La terapia con immunoglubuline (IVIg) nelle neuropatiedisimmuni.NeurolSci2001;22:S431-S435.

219. Lauria G, Chiapparini L, Pareyson D, Sghirlanzoni A. Spinal cord lesion due to epidural anesthesia.NeurolSci2000;21:411-412.

220. Lauria G, Pareyson D, Grisoli M, Sghirlanzoni A. Clinical and MRI findings in chronic sensoryganglionopathies.AnnNeurol2000;47:104-109.

221. Lauria G, Pareyson D, Sghirlanzoni A. Chronic cryptogenic sensory polyneuropathy. Arch Neurol2000:57:759-760.

222. PareysonD, Taroni F, Botti S,MorbinM, Baratta S, LauriaG, Ciano C, Sghirlanzoni A. Cranial nerveinvolvement in CMT disease type 1 due to early growth response gene mutation. Neurology2000;54:1696-1698.

223. Sghirlanzoni A, Lauria G, Lombardi R, Pareyson D. Diagnostica differenziale delle ganglionopatieparaneoplastiche.NeurolSci2000;21:S273-S275.

224. LauriaG,HollandN,HauerPE,CornblathDR,GriffinJW,McArthurJC.Epidermalinnervation:changeswithaging,topographiclocation,andsensoryneuropathy.JNeurolSci1999;164:172-178.

225. LauriaG.Innervationofthehumanepidermis.Ahistoricalreview.ItalJNeurolSci1999;20:63-70.

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226. CasettaI,GranieriE,GilliG,LauriaG,TolaMR,PaolinoE.Temporaltrendandfactorsassociatedwithdelayedhospitaladmissionofstrokepatients.Neuroepidemiology1999;18:255-264

227. LauriaG,McArthur JC,HauerPE,Griffin JW,CornblathDR.Neuropathological alterations indiabetictruncalneuropathy:evaluationbyskinbiopsy.JNeurolNeurosurgPsychiatry1998;65:762-766.

228. FlaniganKM,LauriaG,GriffinJW,KunclRW.Agerelatedbiologyanddiseasesofmuscleandnerves.NeurologicClinics1998:659-669.

229. Lauria G, Gentile M, Fassetta G, et al. Transient global amnesia and transient ischemic attack: acommunity-basedcase-controlstudy.ActaNeurolScand1998;97:381-385.

230. CasettaI,GranieriE,MarchiD,MurgiaSB,TolaMR,TiccaA,LauriaG,GovoniV,MurgiaB,PugliattiM.AnepidemiologicstudyofmultiplesclerosisincentralSardinia,Italy.ActaNeurolScand1998;98:391-394.

231. LauriaG,GentileM,FassettaG,etal. Incidenceof transientglobalamnesia in theBellunoprovince,Italy:1985through1995.Resultsofacommunity-basedstudy.ActaNeurolScand1997;95:303-310.

232. Barrella M, Lauria G, Quatrale R, Paolino E. Hypokaliemic rhabdomyolisis associated with liquoriceingestion:reportofanatipicalcase.ItalJNeurolSci1997;18:217-220.

233. LauriaG,GentileM,FassettaG,etal.IncidenceoftransientischemicattacksintheBellunoprovince,Italy.First-yearresultsofacommunity-basedstudy.ActaNeurolScand1996;93:291-296.

234. LauriaG,GentileM,FassettaG,etal.IncidenceandprognosisofstrokeintheBellunoprovince,Italy.First-yearresultsofacommunity-basedstudy.Stroke1995;26:1787-1793.

235. ZanchinG,DeBoniA,LauriaG,MaggioniF,RossiP,VillacaraA.Synaptosomalglutamateuptakeinamodelofexperimentalcerebralischemia.NeurochemResearch1995;20:195-199.

236. Gentile M, Lauria G. Cephalic tetanus presenting with incomplete Bell’s palsy. Ital J Neurol Sci1994;15:111-113

237. Villacara A, Garbin L, Lauria G, Zanchin G, Galzigna L. Substrate-stimulated oxygen consumption byisolated rat brain microvessels in the presence and absence of ATP. Neurochem Research1993;18:1113-1116.

COAUTOREDICAPITOLIINLIBRI

1. GiuseppeLauria,DanieleCazzato.Prognosisofneurologicalpain.In:Prognosisofneurologicaldiseases.A.Sghirlanzoni,G.Lauria,L.Chiapparini(eds),Springer-Verlag2015

2. LauriaG.,MerkiesI.S.J.,WaxmanS.G.,andFaberC.G.(2014)EpidermalNerveFibers.In:AminoffM.J.andDaroffR.B.(eds.)EncyclopediaoftheNeurologicalSciences,2ndedition,vol.2,pp.76-79.Oxford:AcademicPress.

3. Giuseppe Lauria, Ingemar S.J.Merkies, StephenG.Waxman,CatharinaG. Faber (2013).Approach tosmall fiberneuropathy. In:NeuromuscularDisorders inClinicalPractice.HenryKaminski,RobertRuff,BasharKatir(eds),SpringerNewYork(USA)

4. BianchiRoberto,LombardiRaffaella,Porretta-SerapigliaCarla,LauriaGiuseppe.Intra-EpidermalNerveFibresdensity inErythropoietin-treatedType1diabetic ratswithperipheralneuropathy. In:EPOandtissue-protectivecytokines,MethodsinMolecularBiologyseries,GhezziPandCeramiA(eds),SpringerScience+BusinessMedia,LLC,NewYork,2012

5. Giuseppe Lauria, Paola Penza (2011). Malattie neurologiche degli organi di senso. In:Manuale diNeurologia.GianCamilloManzoniandPaolaTorelli(eds).Esculapio,Bologna,2011,pp45-54

6. LauriaG,HsiehST,JohanssonO,KennedyWR,LegerJM,MellgrenSI,NolanoM,MerkiesISJ,PolydefkisM,SmithAG,SommerC,Valls-SoléJ(2010).EuropeanFederationofNeurologicalSocieties/PeripheralNerve Society Guideline on the Use of Skin Biopsy in the Diagnosis of Small Fibre Neuropathy. In:European Handbook of Clinical Management, Hughes RAC, Brainin M, Gilhus NE (eds), BlackwellPublishing,2010,p94-108

7. Sghirlanzoni A, Lauria G, Pareyson D (2009).Malattie dei nervi periferici. In: Terapia delle malattieneurologiche.p.439-462,MILANO:Springer-VerlagItalia

8. Sommer C., Lauria G (2006). Painful small fiber sensory neuropathies. In:Pain;Handbook of ClinicalNeurology,PJVinken&GWBruyn(eds),ElsevierB.V.,vol.81,p.621-633

9. Lauria G (2007). La gestione della cervicobrachialgia. In:Neuropatie periferiche: casi clinici. SEEd srl,Torino

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10. LauriaG,NolanoM(2005).Labiopsiacutaneanellapraticaclinica.In:TrattatodiNeuropatologia.G.L.Mancardi,F.Tagliavini,G.Vita(eds),Elsevier:Amsterdam,NewYork,vol.2,p.991-1024,

11. SghirlanzoniA,LauriaG,PareysonD.Malattiedelsistemanervosoperiferico.In:Terapiadellemalattieneurologiche con principi di diagnosi. A. Sghirlanzoni, G. Lauria, D. Pareyson, N. Nardocci (eds). Edi-Ermes:Milano,2004

12. LauriaG.Spasticità.In:Terapiadellemalattieneurologicheconprincipididiagnosi.A.Sghirlanzoni,G.Lauria,D.Pareyson,N.Nardocci(eds).Edi-Ermes:Milano,2004

13. Sghirlanzoni A, Lauria G. Complicazioni della Chemioterapia. In Le Complicazioni Neurologiche inOncologiaCaraceniA,SghirlanzoniA,SimonettiF(Eds).Springer,Milano,2006

14. Sghirlanzoni A, Lauria G. Complicazioni della Radioterapia. In Le Complicazioni Neurologiche inOncologiaCaraceniA,SghirlanzoniA,SimonettiF(Eds).Springer,Milano,2006

15. Sghirlanzoni A, Lauria G. Principali Complicazioni Neurologiche della Chirurgia Oncologica. In LeComplicazioniNeurologicheinOncologiaCaraceniA,SghirlanzoniA,SimonettiF(Eds).Springer,Milano,2006

CO-EDITOREDILIBRI

1. Prognosisofneurologicaldiseases.A.Sghirlanzoni,G.Lauria,L.Chiapparini,(eds).Springer-Verlag20152. Terapiadellemalattieneurologicheconprincipididiagnosi.A.Sghirlanzoni,G.Lauria,D.Pareyson,N.

Nardocci(eds).Edi-Ermes:Milano,20043. LocalizzazionedellelesioninelSistemaNervosoPeriferico.A.Sghirlanzoni,G.Lauria,D.Pareyson(eds).

I&VPublisher,Milano,2001.

Milano,01/11/2019GiuseppeLauriaPinter

Ilsottoscrittoèaconoscenzache,aisensidell’art.art.76delDPR445/2000,ledichiarazionimendaci,lafalsitànegliattiel’usodiattifalsisonopunitiaisensidelcodicepenaleedelleleggispeciali.Inoltre,ilsottoscrittoautorizzaaltrattamentodeidatipersonaliaisensidell’art.13D.Lgs.30giugno2003n°196–“Codiceinmateriadiprotezionedeidatipersonali”edell’art.13GDPR679/16–“Regolamentoeuropeosullaprotezionedeidatipersonali”