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Curriculum Vitae Dae Joon Kim, Ph.D.
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Dae Joon Kim, Ph.D.
Associate Professor Department of Molecular Science
School of Medicine University of Texas Rio Grande Valley
1214 W. Schunior RD, Edinburg, TX
78541 E-mail) [email protected]
EDUCATION
1988 – 1992 B.S. Konkuk University, Korea 1992 – 1995 M.S. Konkuk University, Korea 2000 – 2004 Ph.D. in Molecular Toxicology, Integrative Biosciences Graduate
Program, The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA (Advisor: Dr. Jeffrey M. Peters)
PROFESSIONAL EXPERIENCE
03/1992 – 02/1993 Research Assistant, Konkuk University, Korea 03/1993 – 12/1993 Teaching Assistant, Konkuk University, Korea 12/1993 – 06/1994 Visiting Student, Department of Pharmacology, University of Minnesota, MN 01/1995 – 12/1995 Research Assistant, College of Medicine, Konkuk University, Korea
01/1996 – 07/2000 Research Scientist, Samyang Genex Biotechnology Research Institute, Korea
09/2001 – 08/2002 Teaching Assistant, Department of Biochemistry and Molecular
Biology, The Pennsylvania State University, PA 09/2002 – 12/2004 Research Assistant, Department of Veterinary Science, The
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Pennsylvania State University, PA 01/2005 – 07/2005 Postdoctoral Fellow, The Pennsylvania State University, PA
08/2005 – 08/2009 Postdoctoral Fellow, The University of Texas M.D. Anderson Cancer
Center, TX (Advisor: Dr. John DiGiovanni) 09/2009 – 03/2010 Instructor, The University of Texas M.D. Anderson Cancer Center, TX 03/2010 – 07/2010 Research Associate, The University of Texas at Austin, TX
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08/2010 – 08/2015 Assistant Professor, Department of Pharmacology, School of Medicine, The University of Texas health Science Center at San Antonio, TX
09/2015 – 08/2016 Assistant Professor, Department of Molecular Science (previously Biomedical Sciences), School of Medicine, The University of Texas Rio Grande Valley, TX (Transferred to new medical school due to UT strategic plan)
09/2016 – present Associate Professor (Tenure), Department of Molecular Science (previously Biomedical Sciences), School of Medicine, The University of Texas Rio Grande Valley, TX
02/2018 – present Associate Professor (Joint Appointment), Department of Human Genetics, School of Medicine, The University of Texas Rio Grande Valley, TX
ACADEMIC MEMBERSHIPS
03/2011 – 08/2015 Associate Member, Cancer Development and Progression Program,
Cancer Therapy & Research Center, The University of Texas health Science Center at San Antonio, TX
06/2011 – 08/2015 Faculty Member, Cell & Molecular Biology Track, Integrated Multidisciplinary Graduate Program, The University of Texas health Science Center at San Antonio, TX
06/2011 – 08/2015 Faculty Member, Cancer Biology Track, Integrated Multidisciplinary Graduate Program, The University of Texas health Science Center at San Antonio, TX
06/2011 – 08/2015 Faculty Member, Pharmacology Track, Integrated Multidisciplinary Graduate Program, The University of Texas health Science Center at San Antonio, TX
HONORS/AWARDS
1988 – 1991 Undergraduate Scholarship, Konkuk University, Korea 2000 – 2001 Integrative Biosciences Fellowship, The Huck Institutes of the Life Sciences, The
Pennsylvania State University
2002 Second Place Award, The 17th Annual Graduate Exhibition, The
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Pennsylvania State University
2003 Graduate Student Travel Award, The 42nd Annual Meeting of Society of
Toxicology 2003 Predoctoral Travel Award, The American Society for Cell Biology 43rd
Annual Meeting 2003 First Place Award for an Outstanding Presentation, Dermal Toxicology Specialty Section,
The 42nd Annual Meeting of Society of Toxicology
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2004 Second Place Award, The 19th Annual Graduate Exhibition, The Pennsylvania
State
2004 University
Graduate Student Travel Award for the 43rd Annual Meeting of Society of Toxicology,
2005 The Pennsylvania State University First Place Award for an Outstanding Presentation, Dermal Toxicology Specialty
2006 – 2008
Section, The 44th Annual Meeting of Society of Toxicology The M.D. Anderson Odyssey Postdoctoral Fellowship and the H-E-B Foundation Awards
2008 For Scientific Achievement, The University of Texas M.D. Anderson Cancer Center Outstanding Postdoctoral Presentation Award, Dermal Toxicology Specialty Section,
2008 The 47th Annual Meeting of Society of Toxicology
AACR-Busch Scholar-in-Training Award, The 99th Annual Meeting of American
2009 Association for Cancer Research First Place Postdoctoral Presentation Award, Korean Toxicologists Association in
2009 America, The 48th Annual Meeting of Society of Toxicology The AMGEN Award in Basic Science Research, Trainee Research Day, The University
2010 of Texas M.D. Anderson Cancer Center Stratacor – Port Royal Postdoctoral Award, Dermal Toxicology Specialty Section,
2011 The 49th Annual Meeting of Society of Toxicology The Annual Paper of the Year Award, Dermal Toxicology Specialty Section, The 50th
2012 Annual Meeting of Society of Toxicology AACR Minority-Serving Institution Faculty Scholar in Cancer Research Award, The
2013 103rd Annual Meeting of American Association for Cancer Research AACR Minority-Serving Institution Faculty Scholar in Cancer Research Award, The
2014 104th Annual Meeting of American Association for Cancer Research AACR Minority-Serving Institution Faculty Scholar in Cancer Research Award, The
2018
105th Annual Meeting of American Association for Cancer Research Marquis Who’s Who in America
PROFESSIONAL MEMBERSHIPS
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2002 – present Society of Toxicology 2003 – present The American Society for Cell Biology 2005 – present American Association for Cancer Research 2018 – present American Society for Photobiology
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CONFERENCES AND SYMPOSIA
Administrative positions and committee memberships
2008 – 2010 Postdoctoral Representative for Dermal Toxicology Specialty Section, Society of Toxicology
2017 Ambassador, American Society of Cell Biology
Session chairmanships
2009 Co-Chair of Chemical Carcinogenesis Poster Session, The 48th Annual Meeting of Society of Toxicology
TEACHING
Supervisory Teaching
Advisory Committees and Supervisory Committees (Graduate Students)
Mohammad Albataineh, Microbiology & Immunology Track, Integrated Multidisciplinary Graduate Program, UT Health Science Center at San Antonio, 2010 – 2015
Andrew Robles, Pharmacology Track, Integrated Multidisciplinary Graduate Program, UT Health Science Center at San Antonio, 2013 - 2015
Nick Hargreaves, Pharmacology Track, Integrated Multidisciplinary Graduate Program, UT Health Science Center at San Antonio, 2014 - 2015
Direct Supervision
Undergraduate student supervision
Karina Mercado, University of Texas at Pan America, Summer student program, 2011 Alex Garcia, University of Texas at Pan America, Summer student program, 2012 Mario Capetillo, University of Texas at Pan America, HHMI training program, 06/2013 - 05/2015 Annsuriya Saji, Pre-med program student, University of Texas Rio Grande Valley, 09/2017 – 05/2019 Justina Jose, Pre-med program student, University of Texas Rio Grande Valley, 09/2017 – 05/2019
Medical student supervision
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Ibrahim Odewale, University of Texas Rio Grande Valley, Summer Research, 05/2018 – 08/2018 Anna Archbold, University of Texas Rio Grande Valley, Research elective course, 2018
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Postdoctoral research supervision
Young Suk Lee, Ph.D., Chungnam National University, Korea, 05/2011 - 04/2013 Gyuyoup Kim, Ph.D., Seoul National University, Korea, 05/2011 - 04/2012 Jun Wan Shin, Ph.D., Seoul National University, Korea, 07/2012 - 03/2014 Hyunseung Lee, Ph.D., Seoul National University, Korea, 06/2013 - 12/2016 Pinki Anand, Ph.D., University of Delhi, India, 12/2015 – 07/2016 Minwoo Baek, Ph.D., Chonnam National University, Korea, 03/2016 - 08/2017 Jaesung Lim, Ph.D., Chonnam National University, Korea, 01/2017 – 12/2017 Cheol Jung Lee, Ph.D., The Catholic University of Korea, Korea, 03/2019 - present
SERVICE
UTRGV Campuswide
2016 - Member, Animal Research Care Committee 2018 - Member, University Faculty Senate
UTRGV School of Medicine
2017 Member, Faculty Compensation and Incentive Planning Committee 2017 Member, Research & Innovation Workgroup, Strategic Planning
Committee 2017 - 2019
Member, Promotion Tenure Appointment Committee
2017 - 2019
Search Committee Member, Department of Biomedical Sciences
2018 Member, Research Symposium Planning Committee 2018 Member, Research Symposium Scientific Committee
EDITORIAL AND REVIEW ACTIVITIES
Editor/Service on Editorial Board(s)
2010 – present Editorial Board Member, Journal of Cancer Science & Therapy
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Research Journal Reviewer
American Journal of Pathology, Cancer Letters, Journal of Investigative Dermatology, Molecular Carcinogenesis, Oncogene, Oncotarget, Plos One, Scientific Reports, Toxicological Sciences
RESEARCH GRANTS
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Active:
1. Project #: R01 ES022250 Funding Agency: NIH/NIEHS Title: The role of TC-PTP in skin carcinogenesis Status: Complete Period: 08/2013 – 05/2018 Role: Principal Investigator % Effort: 40 Total Costs: $1,681,875 ($1,125,000 direct) Grant Detail: The major goal of this project is to explore the specific functional role of TC-PTP in the cellular mechanisms involved in environmental skin carcinogenesis.
INVITED PRESENTATIONS
Invited Presentations at National or International Conferences
1. Targeted disruption of signal transducer and activator of transcription 3 (Stat3) in
bulge region keratinocyte stem cells inhibits chemically-induced skin carcinogenesis.
Minisymposium, The 99th Annual Meeting of American Association for Cancer Research, San Diego, CA, April 2008.
2. Stat3 in keratinocyte stem cells is required for initiation of epithelial carcinogenesis. The
17th CRI Cancer Symposium, Seoul National University, Korea, June 2008. 3. T-cell protein tyrosine phosphatase (TC-PTP) dephosphorylates Stat3 in keratinocytes
following exposure to UVB. The 10th Biennial FASEB Summer Research Conference for Protein Phosphatases, Snowmass, CO, July 2008.
4. T-cell protein tyrosine phosphatase (TC-PTP) as a potential target for skin cancer prevention. Seoul National University Cancer Research Institute Annual Symposium, Korea, April 2014
5. Emerging role of TC-PTP in the suppression of UVB-induced keratinocyte survival and proliferation. American Society for Photobiology Biennial Meeting, Tampa, FL, May 2018.
6. Regulation of T-cell protein tyrosine phosphatase subcellular localization by UVB
radiation in keratinocytes. The 13th International Skin Carcinogenesis Conference, Austin, TX, October 2018.
Seminar Invitations from Other Institutions
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1. T-cell protein tyrosine phosphatase dephosphorylates Stat3 in keratinocytes following exposure to UVB. College of Dentistry, Yonsei University, Korea, June 2008.
2. T-cell protein tyrosine phosphatase dephosphorylates Stat3 in keratinocytes following exposure to UVB. Korea Basic Research Institute, Korea, June 2008.
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3. T-cell protein tyrosine phosphatase dephosphorylates Stat3 in keratinocytes following exposure to UVB. Korea Institute of Science and Technology, Korea, June 2008.
4. Stat3 signaling in epithelial carcinogenesis. College of Dentistry, University of Nebraska Medical Center, March 2010.
5. Stat3 signaling in epithelial carcinogenesis. Department of Cellular & Structural Biology, The University of Texas health Science Center at San Antonio, May 2011.
6. Protein tyrosine phosphatases in skin. Toxicology Seminar in College of Pharmacy, The University of Texas at Austin, February 2013
7. Tyrosine phosphorylation signaling in epithelial carcinogenesis. College of Animal Bioscience & Technology, Konkuk University, Korea, March 2013
8. Tyrosine phosphorylation signaling in epithelial carcinogenesis. College of Natural Sciences, Sungsil University, Korea, March 2013
9. T-cell protein tyrosine phosphatase (TC-PTP) as a potential target for skin cancer prevention. Department of Pharmaceutical and Biomedical Sciences, University of Georgia, December 2013.
10. T-cell protein tyrosine phosphatase (TC-PTP) as a potential target for skin cancer prevention. Department of Environmental Health, University of Cincinnati, December 2013.
11. T-cell protein tyrosine phosphatase (TC-PTP) as a potential target for skin cancer prevention. Institute for New Drug Development, Keimyung University, Korea, April 2014.
12. T-cell protein tyrosine phosphatase (TC-PTP) as a potential target for skin cancer prevention. Translational Research Center for Protein Function Control, Yonsei University, Korea, April 2014.
13. T-cell protein tyrosine phosphatase (TC-PTP) as a potential target for skin cancer prevention. College of Pharmacy, The Catholic University of Korea, Korea, April 2014.
14. T-cell protein tyrosine phosphatase (TC-PTP) as a potential target for skin cancer prevention. Hyundai Pharm. Research Institute, Korea, April 2014.
15. T-cell protein tyrosine phosphatase (TC-PTP) as a potential target for skin cancer prevention. Division of Biological Science and Technology, Yonsei University, Korea, April 2014.
16. T-cell protein tyrosine phosphatase (TC-PTP) as a potential target for skin cancer prevention. Department of Anatomy and Cell Biology, University of Florida, May 2014.
17. T-cell protein tyrosine phosphatase (TC-PTP) as a potential target for skin cancer
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prevention. Department of Biochemistry and Molecular Biology, University of Maryland, May 2014.
18. T-cell protein tyrosine phosphatase as a potential target for skin cancer prevention. Biomedical Studies Thematic Community Seminar Series, University of Texas at Pan American, September 2014.
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19. T-cell protein tyrosine phosphatase as a potential target for skin cancer prevention. Department of Dermatology, Boston University, October 2014.
20. Protein tyrosine phosphatase in environmental carcinogenesis. Bloomberg School of Public Health, Johns Hopkins University, October 2014.
21. T-cell protein tyrosine phosphatase in environmental carcinogenesis. Seminar in Environmental Health Sciences Graduate Program, University of California at Irvine, May 2015.
22. A novel mechanism in osteosarcoma chemoresistance. Cancer Development and Progression Program Research Forum, University of Texas Health Science Center at San Antonio, September 2015.
23. Protein tyrosine phosphatase in environmental carcinogenesis. Department of Dermatology, University of Wisconsin-Madison, December 2015.
24. Protein tyrosine phosphatase in environmental carcinogenesis. Department of Cell Biology, Microbiology, and Molecular Biology, University of South Florida, October 2016.
25. T-cell protein tyrosine phosphatase in environmental skin carcinogenesis. Institute of Environmental Health Sciences, Wayne State University, January 2017.
26. GFRA1: a novel molecular target for the prevention of osteosarcoma chemoresistance. College of Pharmacy, The Catholic University of Korea, Korea, June 2018.
27. GFRA1: a novel molecular target for the prevention of osteosarcoma chemoresistance. Korea Research Institute of Bioscience & Biotechnology, Korea, June 2018.
28. GFRA1: a novel molecular target for the prevention of osteosarcoma chemoresistance. Korea Basic Research Institute, Korea, June 2018.
29. GFRA1: a novel molecular target for the prevention of osteosarcoma chemoresistance. College of Life Science and Nano Technology, Hannam University, Korea, June 2018.
30. GFRA1: a novel molecular target for the prevention of osteosarcoma chemoresistance. Translational Research Center for Protein Function Control, Yonsei University, Korea, June 2018.
31. T-cell protein tyrosine phosphatase (TC-PTP) in the regulation of keratinocyte survival and proliferation. Computation Systems Biology Seminar Series in Collaborative Genome Program and Basic Science Research Program, Chonnam National University,
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Korea, September 2018.
PUBLICATIONS
1. Kim, D.J., Akiyama, T.E., Harman, F.S., Burns, A.M., Shan, W., Kennett, M.J., Ward,
J.M., Gonzalez, F.J., and Peters, J.M. Peroxisome proliferator-activated receptor �()-dependent regulation of ubiquitin C expression contributes to attenuation of skin carcinogenesis. Journal of Biological Chemistry 279:23719-23727, 2004.
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2. Kim, D.J., Murray, I.A., Burns, A.M., Gonzalez, F.J., Perdew, G.H., and Peters, J.M. Peroxisome proliferator-activated receptor �() inhibits epidermal cell proliferation by down-regulation of kinase activity. Journal of Biological Chemistry 280:9519-9527, 2005.
3. Burdick, A.D., Kim, D.J., Peraza, M.A., Gonzalez, F.J., and Peters, J.M. The role of peroxisome proliferator-activated receptor-�/ in epithelial cell growth and differentiation. Review. Cellular Signaling 18:9-20, 2006.
4. Patel, R.D., Kim, D.J., Peters, J.M., and Perdew, G.H. The aryl hydrocarbon receptor directly regulates expression of the potent mitogen epiregulin. Toxicological Sciences 89:75-82, 2006.
5. Kim, D.J., Prabhu, K.S., Gonzalez, F.J., and Peters, J.M. Inhibition of chemically-induced skin carcinogenesis by sulindac is independent of peroxisome proliferator-activated receptor �/ (PPAR�/). Carcinogenesis 27:1105-1112, 2006.
6. Kim, D.J., Bility, M.T., Willson, T.M., Billin, A.N., Gonzalez, F.J., and Peters, J.M. Peroxisome proliferator-activated receptor � () selectively induces differentiation and inhibits cell proliferation. Cell Death & Differentiation 13:53-60, 2006.
7. Kim, D.J., Chan, K.S., Sano, S., and DiGiovanni, J. Signal transducer and activator of transcription 3 (Stat3) in epithelial carcinogenesis. Review. Molecular Carcinogenesis 46:725- 731, 2007. PMID: 17610223.
8. Kataoka, K.*, Kim, D.J.*, Carbajal, S., Clifford J., and DiGiovanni, J. Stage-specific disruption of Stat3 demonstrates a requirement during both initiation and promotion stages of mouse skin tumorigenesis. Carcinogenesis 29:1108-1114, 2008. (*Co-first authors) PMCID: PMC2902397.
9. Kim, D.J., Angel, J.M., Sano, S., and DiGiovanni, J. Constitutive activation and targeted disruption of signal transducer and activator of transcription 3 (Stat3) in mouse epidermis reveal its critical role in UVB-induced skin carcinogenesis. Oncogene 28:950-960, 2009. PMCID: PMC2645481.
10. Kim, D.J., Kataoka, K., Sano, S., Connolly, K., Kiguchi, K., and DiGiovanni, J. Targeted disruption of Bcl-xL in mouse keratinocytes inhibits both UVB- and chemically-induced skin carcinogenesis. Molecular Carcinogenesis 48:873-885, 2009. PMCID: PMC4066197.
11. Kim, D.J., Kataoka, K., Rao, D., Kiguchi, K., Cotsarelis, G., and DiGiovanni, J. Targeted disruption of Stat3 reveals a major role for follicular stem cells in skin tumor initiation. Cancer Research 69:7587-7594, 2009. Highlight article. PMCID: PMC4043290.
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12. Kim, D.J.*, Tremblay, M.L., and DiGiovanni, J.* Protein tyrosine phosphatases, TC-PTP, SHP1, and SHP2, cooperate in rapid dephosphorylation of Stat3 in keratinocytes following UVB irradiation. PLoS One 5:e10290, 2010. (*Co-corresponding authors) PMCID: PMC2858656.
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13. Rho, O.*, Kim, D.J.*, Kiguchi, K., and DiGiovanni, J. Growth factor signaling pathways as targets for prevention of epithelial carcinogenesis. Review. Molecular Carcinogenesis 50: 264- 279, 2011. (*Co-first authors) PMCID: PMC3005141.
14. Morales, L.D., Pena, K., Kim, D.J., and Lieman, J.H. SHP-2 and PTP-PEST induction during RB-E2F associated apoptosis. Cellular & Molecular Biology Letters 17:422-432, 2012. PMID: 22644489.
15. Bandyopadhyay, D., Cruz, J., Morales, L.D., Arman, H.D., Cuate, E., Lee, Y.S., Banik, B.K.*, and Kim, D.J.* A green approach toward quinoxalines and bis-quinoxalines and their biological evaluation against A431, human skin cancer cell lines. Future Medicinal Chemistry 5(12):1377- 1390, 2013. (*Co-corresponding authors) PMID: 23919545.
16. Junco, J.J., Mancha, A., Malik, G., Wei, S.J., Kim, D.J., Liang, H., and Slaga, T.J. Resveratrol and P-glycoprotein inhibitors enhance the anti-skin cancer effects of ursolic acid. Molecular Cancer Research 11:1521-1529, 2013. PMCID: PMC3869897.
17. Zhang, Y., Chang, F.M., Huang, J., Junco, J.J., Maffi, S.K., Pridgen, H.I., Catano, G., Dang, H., Ding, X., Yang, F., Kim, D.J., Slaga, T.J., He, R., and Wei, S.J. DSSylation, a novel protein modification targets proteins induced by oxidative stress, and facilitates their degradation in cells. Protein & Cell 5:124-140, 2014. PMCID: PMC3956975.
18. Morales, L.D., Casillas Pavón, E.A., Shin, J.W., Garcia, A., Capetillo, M., Kim, D.J.*, and Lieman, J.H.* Protein tyrosine phosphatases PTP1B, SHP2, and PTEN facilitate Rb/E2F- associated apoptotic signaling. PLoS One 9:e97104, 2014. (*Co-corresponding authors) PMCID: PMC4014576.
19. Lee, H., Morales, L., Slaga, T.J., and Kim, D.J. Activation of T-cell protein tyrosine phosphatase suppresses keratinocyte survival and proliferation following UVB irradiation. Journal of Biological Chemistry 290:13-24, 2015. PMCID: PMC4281716.
20. Junco, J.J., Mancha, A., Malik, G., Wei, S.J., Kim, D.J., Liang, H., and Slaga, T.J. Ursolic acid and resveratrol synergize with chloroquine to reduce melanoma cell viability. Melanoma Research 25:103-112, 2015. PMID: 25647735.
21. Lee, H., Kim, M., Morales, L., Riggs, P.K., DiGiovanni, J., and Kim, D.J. Constitutive activation of Stat3 in mouse epidermis is linked to hair deficiency and cytoskeletal network damage. Experimental Dermatology 24:796-798, 2015. PMID: 25940573.
22. Hwang, J.H., Joo, J.C., Kim, D.J., Jo, E., Yoo, H.S., Lee, K.B., Park, S.J., and Jang, I.S. Cordycepin promotes apoptosis by modulating the ERK-JNK signaling pathway via DUSP5 in renal cancer cells. American Journal of Cancer Research 6(8):1758-1771, 2016. PMCID: PMC5004077.
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23. Kim, M., Jung, J., Choi, S., Lee, H., Morales, L.D., Koh, J.T., Kim, S.H., Choi, Y., Choi, C., Slaga, T.J., Kim, W.J.*, and Kim, D.J.* GFRA1 promotes cisplatin-induced chemoresistance in osteosarcoma by inducing autophagy. (*Co-corresponding authors) Autophagy 13:149-168, 2017. PMCID: PMC5240831.
24. Lee, H., Kim, M., Baek, M., Morales, L.D., Jang, I.S., Slaga, T.J., DiGiovanni, J., and Kim, D.J. Targeted disruption of TC-PTP in the proliferative compartment augments STAT3 and AKT signaling and skin tumor development. Scientific Reports 7:45077, 2017. PMCID: PMC5359614.
25. Kim, M., Baek, M., and Kim, D.J. Tyrosine phosphorylation signaling and its potential therapeutic implications in carcinogenesis. Review. Current Pharmaceutical Design 23:4226- 4246, 2017. PMID: 28625132.
26. Joo, J.C., Hwang, J.H., Jo, E., Kim, Y.R., Kim, D.J., Lee, K.B., Park, S.J., and Jang, I.S. Cordycepin induces apoptosis by caveolin-1-mediated JNK regulation of Foxo3a in human lung adenocarcinomas. Oncotarget 8(7):12211-12224, 2017. PMCID: PMC5355338.
27. Hwang, J.H., Park, S.J., Ko, W.G., Kang, S.M., Lee, D.B., Bang, J., Park, B.J., Wee, C.B., Kim, D.J., Jang, I.S., and Ko, J.H. Cordycepin induces human lung cancer cell apoptosis by inhibiting nitric oxide mediated ERK/Slug signaling pathway. American Journal of Cancer Research 7:417- 432, 2017. PMCID: PMC5385633.
28. Kim, M., Morales, L., Baek, M., Slaga, T.J., DiGiovanni, J., and Kim, D.J. UVB-induced nuclear translocation of TC-PTP by AKT/14-3-3 axis inhibits keratinocyte survival and proliferation. Oncotarget 8:90674-90692, 2017. PMCID: PMC5710877. Cover Article and Priority Research Paper.
29. Kim, M., Morales, L., and Kim, D.J. TC-PTP nuclear trafficking in keratinocytes. Editorial. Aging 9:2459-2460, 2017. PMID: 29232657.
30. Kim, M. and Kim, D.J. GFRA1: A novel molecular target for the prevention of osteosarcoma chemoresistance. Review. International Journal of Molecular Sciences 19:1078, 2018. PMID: 29617307.
31. Cui, Z.Y., Park, S.J., Jo, E., Hwang, J.H., Lee, K.B., Kim, S.W., Kim, D.J., Joo, C.J., Hong, S.H., Lee, M.G., and Jang, I.S. Cordycepin induces apoptosis of human ovarian cancer cells by inhibiting CCL5-mediated AKT/NF-B signaling pathway. Cell Death Discovery, 4:62, 2018. PMCID: PMC5966410.
32. Baek, M., Kim, M., Lim, J.S., Morales, L.D., Hernandez, J., Mummidi, S., Williams-Blangero, S., Jang, I.S., Tsin, A.T., and Kim, D.J. Epidermal-specific deletion of TC-PTP
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promotes UVB- induced epidermal cell survival through the regulation of Flk-1/JNK signaling. Cell Death & Disease 9:730, 2018. PMCID: PMC6023867.
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33. Junco, J.J., Cho, J., Mancha, A., Malik, G., Wei, S.J., Kim, D.J., Liang, H., DiGiovanni, J., and Slaga, T.J. Role of AMPK and PPAR in the anti-skin cancer effects of ursolic acid. Molecular Carcinogenesis 57:1698-1706, 2018. PMID: 30129681.
34. Kim, M., Morales, L.D., Jang, I.S., Cho, Y.Y., and Kim, D.J. Protein tyrosine phosphatases as potential regulators of STAT3 signaling. Review. International Journal of Molecular Sciences 19:2708, 2018. PMID: 30208623.
35. Mancha-Ramirez, A., Yang, X., Liang, H., Junco, J.J., Lee, K.P., Bovio, S.F., Espinoza, M., Wool, J., Slaga, A., Glade, D.C., Hanes, M., Malik, G., Kim, D.J., DiGiovanni, J., and Slaga, T.J. Harnessing the gatekeepers of glucocorticoids for chemoprevention of non-melanoma skin cancer. Molecular Carcinogenesis 58:102-112, 2019. PMID: 30302860.
36. Song, J.H., Lee, C.J., An, H.J., Yoo, S.M., Kang, H.C., Lee, J.Y., Kim, K.D., Kim, D.J., Lee, H.S., and Cho, Y.Y. Magnolin targeting of ERK1/2 inhibits cell proliferation and colony growth by induction of cellular senescence in ovarian cancer cells. Molecular Carcinogenesis 58:88-101, 2019. PMID: 30230030.
37. Yoo, S.M., Lee, C.J., Kang, H.C., Lee, H.S., Lee, J.Y., Kim, K.D., Kim, D.J., An, H.J., and Cho, Y.Y. Epimagnolin targeting on an active pocket of mammalian target of rapamycin suppressed cell transformation and colony growth of lung cancer cells. Molecular Carcinogenesis In press.
38. Yoo, S.M., Lee, C.J., An, H.J., Lee, J.Y., Lee, H.S., Kang, H.C., Cho, S.J., Kim, S.M., Park, J., Kim, D.J., and Cho, Y.Y. RSK2-mediated ELK3 activation enhances cell transformation and breast cancer cell growth by regulation of c-fos promoter activity. International Journal of Molecular Sciences. In press.
39. Peters, J.M., Kim, D.J., Bility, M.T., Borland, M.G., Zhu, B., and Gonzalez, F.J. Regulatory mechanisms mediated by peroxisome proliferator-activated receptor-�/ (PPAR�/) in skin cancer. Review. Molecular Carcinogenesis. In press.
40. Lee, C.J., An, H.J., Kim, S.M., Kim, W.Y., Kim, D.J., Kang, H.C., Lee, J.Y., Lee, H.S., Cho, S.J., and Cho, Y.Y. FBXW7-mediated stability regulation of signal transducer and activator of transcription 2 in melanoma formation. EMBO Journal. Submitted.
41. Kim, M., Morales, L.D., Olivarez, S.A., Hernandez, J., Mummidi, S., Tsin, A.T., Jang, I.S., Slaga, T.J., Cho, Y.Y., and Kim, D.J. Overexpression of TC-PTP in murine epidermis attenuates skin cancer formation. Oncogene. Submitted.
42. Morales, L.D., Archbold, A.K., Olivarez, S.A., DiGiovanni, J., and Kim, D.J. The role of T-cell protein tyrosine phosphatase in carcinogenesis. Review. Molecular
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Carcinogenesis. In revision.
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43. Jang, H.J., Hwang, I.H., Huh, Y.H., Yang, K.E., Kim, D.J., Yoo, H.S., Park, S.J., and Jang, I.S. Cordycepin inhibits human ovarian cancer by inducing autophagy and apoptosis through Dickkopf-related protein 1/�-catenin signaling. Molecular Cancer Therapeutics. Submitted.
PRESENTATIONS/ABSTRACTS
1. Kim, D.J., Gonzalez, F.J., and Peters, J.M. Enhanced skin carcinogenicity in
peroxisome proliferator-activated receptor � null mice. The 41st Annual Meeting of Society of Toxicology, March 2002.
2. Harman, F.S., Yim, S., Kim, D.J., Gonzalez, F.J., and Peters, J.M. Molecular and biochemical alterations in peroxisome proliferator-activated receptor � null mouse skin
in response to 12-O- tetradecanoylphorbol-13-actate (TPA). The 41st Annual Meeting of Society of Toxicology, March 2002.
3. Kim, D.J. and Peters, J.M. Role of peroxisome proliferator-activated receptor �
(PPAR�) in mouse keratinocyte proliferation and differentiation. The 42nd Annual Meeting of Society of Toxicology, March 2003. Presentation/Travel Awards.
4. Peters, J.M., Kim, D.J., and Gonzalez, F.J. The role of PPAR�() in epithelial cell proliferation. Second International Symposium on PPARs: From Basic Science To Clinical Applications, March 2003. Florence, Italy. p23.
5. Kim, D.J., Gonzalez, F.J., and Peters, J.M. Identification and preliminary characterization of a PPAR� target gene in skin. The American Society for Cell
Biology 43rd Annual Meeting, December 2003. Molecular Biology of the Cell 14 (Supplement): 415a. Travel Award.
6. Kim, D.J. and Peters, J.M. Modulation of PKC/MAPK signaling pathway by
peroxisome proliferator-activated receptor � (PPAR�). The 43rd Annual Meeting of Society of Toxicology, March 2004. Travel Award.
7. Kim, D.J. and Peters, J.M. PPAR�-dependent regulation of epidermal cell proliferation via modulation of protein kinase C and ERK activity. The American
Society for Cell Biology 44th Annual Meeting, December 2004. Molecular Biology of the Cell 15 (Supplement) #L51.
8. Kim, D.J., Billin, A.N., Willson, T.M., and Peters, J.M. Peroxisome proliferator-activated receptor � (PPAR�) selectively regulates differentiation and cell
Curriculum Vitae Dae Joon Kim, Ph.D.
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proliferation. The 44th Annual Meeting of Society of Toxicology, March 2005. Presentation Award.
9. Devlin, M.K, Kim, D.J., Billin, A.N., Willson, T.M., and Peters, J.M. The peroxisome proliferator-activated receptor � (PPAR�) agonist GW0742 inhibits skin carcinogenesis.
The 44th Annual Meeting of Society of Toxicology, March 2005.
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10. Bility, M.T., Kim, D.J., Billin, A.N., Willson, T.M., and Peters, J.M. Transcriptional regulation of tissue-specific inhibitor of matrix metalloproteinase 1 (TIMP1) by
peroxisome proliferator- activated receptor � (PPAR�). The 44th Annual Meeting of Society of Toxicology, March 2005.
11. Kim, D.J., Devlin, M.K., Bility, M.T., Gonzalez, F.J., Billin, A.N., Willson, T.M., and Peters, J.M. PPAR�()-dependent regulation of cell proliferation, differentiation, and
carcinogenesis: studies from null mouse models. 3rd International Symposium on PPARs: Efficacy and Safety, March 2005. Monte Carlo, Monaco. p2.
12. Burdick, A.D., Bility, M.T., Kim, D.J., Billin, A.N., Willson, T.M., and Peters, J.M. PPAR� induces differentiation and inhibits cell proliferation in human and murine keratinocytes.
The 45th Annual Meeting of Society of Toxicology, March 2006. 13. Kim, D.J., Kataoka, K., Sano, S., Chan, K.S., and DiGiovanni, J. The functional role of
signal transducer and activator of transcription 3 (Stat3) in UVB-induced skin
carcinogenesis. The 97th Annual Meeting of American Association for Cancer Research, April 2006. Abstract #2844.
14. Kataoka, K., Kim, D.J., Chan, K.S., Sano, S., Carbajal, S., Hollek, L., Clifford, J., and DiGiovanni, J. Stage-specific disruption of Stat3 demonstrates a requirement during both initiation and promotion stages of mouse skin carcinogenesis. The
97th Annual Meeting of American Association for Cancer Research, April 2006. Abstract #2842.
15. Kim, D.J. and DiGiovanni, J. Negative regulation of Stat3 signaling by T-cell protein
tyrosine phosphatase (TC-PTP) in skin following UVB irradiation. The 7th
International Skin Carcinogenesis Conference, November 2006. 16. Kim, D.J. and DiGiovanni, J. UVB-induced dephosphorylation of Stat3 by T-cell
protein tyrosine phosphatase (TC-PTP). The American Society for Cell Biology 46th
Annual Meeting, December 2006. Molecular Biology of the Cell 17 (Supplement) #1992.
17. Kim, D.J., Tremblay, M.L., and DiGiovanni, J. T-cell protein tyrosine phosphatase (TC-
PTP) regulates Stat3 signaling in mouse epidermis after UVB irradiation. The 98th
Annual Meeting of American Association for Cancer Research, April 2007. Abstract #3920.
18. Kim, D.J., Riggs, P.K., Kataoka, K., and DiGiovanni, J. Constitutive activation of Stat3 in
Curriculum Vitae Dae Joon Kim, Ph.D.
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mouse epidermis (BK5.Stat3C) is linked to hair growth deficiency and cytoskeletal
network damage: Gene expression profiling of BK5.Stat3C mice. The 68th Annual Meeting of Society of Investigative Dermatology, May 2007. Abstract #569.
19. Kim, D.J. and DiGiovanni, J. Constitutive activation and targeted disruption of signal transducer and activator of transcription 3 (Stat3) in mouse epidermis reveal its critical
role in UVB-induced skin carcinogenesis. The 47th Annual Meeting of Society of Toxicology, March 2008. Abstract #530. Presentation Award.
Curriculum Vitae Dae Joon Kim, Ph.D.
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20. Kim, D.J., Kataoka, K., Rao, D., Cotsarelis, G., and DiGiovanni, J. Targeted disruption
of Stat3 reveals a major role for follicular stem cells in skin tumor initiation. The 8th
International Skin Carcinogenesis Conference, October 2008.
21. Kim, D.J., Kataoka, K., Sano, S., and DiGiovanni, J. Targeted disruption of Bcl-xL in mouse keratinocytes inhibits both UVB- and chemically-induced skin carcinogenesis.
The 48th Annual Meeting of Society of Toxicology, March 2009. Abstract #1650. Presentation Award.
22. Kim, D.J., Kataoka, K., Sano, S., and DiGiovanni, J. Impact of Bcl-xL deficiency in mouse keratinocytes on susceptibility to both UVB- and chemically-induced skin
carcinogenesis. The 100th Annual Meeting of American Association for Cancer Research, April 2009.
23. Rao, D., Kim, D.J., Carbajal, S., Kiguchi, K., and DiGiovanni, J. Impact of Stat3
activation on target cells for skin tumor development. The 100th Annual Meeting of American Association for Cancer Research, April 2009.
24. Kim, D.J. and DiGiovanni, J. Protein tyrosine phosphatases, TC-PTP, SHP1, and SHP2,
cooperate in rapid dephosphorylation of Stat3 in skin following UVB irradiation. The 49th
Annual Meeting of Society of Toxicology, March 2010. Abstract #1671. Presentation Award.
25. Kim, D.J., Tremblay, M.L., and DiGiovanni, J. Cooperative regulation of Stat3 signaling
by TC- PTP, SHP1, and SHP2 in keratinocytes following UVB irradiation. The 101st Annual Meeting of American Association for Cancer Research, April 2010. Abstract #4007.
26. Kim, D.J., Tremblay, M.L., and DiGiovanni, J. TC-PTP, SHP1, and SHP2 cooperate in
UVB- mediated dephosphoorylation of Stat3 in keratinocytes. The 9th International Skin Carcinogenesis Conference, June 2010.
27. Lee, Y.S., Morales, L., Slaga, T.J., DiGiovanni, J., and Kim, D.J. UVB irradiation
induces nuclear translocation of TC-PTP in keratinocytes. The 103rd Annual Meeting of American Association for Cancer Research, April 2012. Abstract #2537.
28. Lee, Y.S., Morales, L., Slaga, T.J., DiGiovanni, J., and Kim, D.J. Nuclear translocation
of TC- PTP in skin following UVB irradiation. The 10th International Skin Carcinogenesis Conference, June 2012.
29. Lee, Y.S., Shin, J.W., Morales, L., Slaga, T.J., and Kim, D.J. The role of T-cell protein tyrosine phosphatase (TC-PTP) in UVB-induced epidermal cell proliferation and
Curriculum Vitae Dae Joon Kim, Ph.D.
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survival. The 104th Annual Meeting of American Association for Cancer Research, April 2013. Abstract #3586.
30. Shin, J.W., Lee, Y.S., Morales, L., Slaga, T.J., and Kim, D.J. TC-PTP regulates UVB-induced epidermal cell proliferation and survival by modulating Stat3 signaling. The
28th Aspen Cancer Conference, July 2013.
Curriculum Vitae Dae Joon Kim, Ph.D.
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31. Shin, J.W., Lee, H., Morales, L., Slaga, T.J., and Kim, D.J. T-cell protein tyrosine phosphatase (TC-PTP) inhibits UVB-induced keratinocyte survival and proliferation by regulating Stat3 signaling. Lone Star Regional Chapter (LSSOT) Annual Meeting, Society of Toxicology, October 2013.
32. Shin, J.W., Lee, H., Morales, L., Slaga, T.J., and Kim, D.J. TC-PTP inhibits UVB-induced
keratinocyte survival and proliferation by regulating Stat3 signaling. The 53rd Annual Meeting of Society of Toxicology, March 2014. Abstract #1736.
33. Morales, L.D., Capetillo, M., Casillas Pavón, E.A., Shin, J.W., Garcia, A., Lieman, J.H., and Kim, D.J. Protein tyrosine phosphatase PTP-1B, SHP-2 and PTEN facilitate
Rb/E2F-associated apoptotic signaling. The 105th Annual Meeting of American Association for Cancer Research, April 2014. Abstract #1353.
34. Lee, H., Morales, L., Slaga, T.J., and Kim, D.J. Activation of T-cell protein tyrosine phosphatase suppresses keratinocyte survival and proliferation following UVB
irradiation. The 54th Annual Meeting of Society of Toxicology, March 2015. Abstract #1282.
35. Lee, H., Kim, M., Morales, L., Slaga, T.J., and Kim, D.J. Activation of T-cell protein tyrosine phosphatase suppresses keratinocyte survival and proliferation following UVB
irradiation. The 106th Annual Meeting of American Association for Cancer Research, April 2015. Abstract #4567.
36. Kim, M., You, H.J., and Kim, D.J. APE/Ref1 promotes cell adhesion and migration in
cervical cancer cells. The 106th Annual Meeting of American Association for Cancer Research, April 2015. Abstract #5097.
37. Lee, H., Kim, M., Morales, L., Vazquez, A.K., Slaga, T.J., DiGiovanni, J., and Kim, D.J. Targeted disruption of T-cell protein tyrosine phosphatase in mouse epidermis
promotes chemically-induced skin carcinogenesis. The 55th Annual Meeting of Society of Toxicology, March 2016. Abstract #2065.
38. Lee, H., Kim, M., Morales, L., Slaga, T.J., DiGiovanni, J., and Kim, D.J. Targeted disruption of T-cell protein tyrosine phosphatase in mouse epidermis reveals its critical
role in chemically- induced skin carcinogenesis. The 107th Annual Meeting of American Association for Cancer Research, April 2016. Abstract #4071.
39. Baek, M., Kim, M., Lim, J., Slaga, T.J., DiGiovanni, J., and Kim, D.J. Targeted disruption of TC-PTP in the proliferative compartment augments STAT3 and AKT
Curriculum Vitae Dae Joon Kim, Ph.D.
31
signaling and skin tumor development. The 32th Aspen Cancer Conference, July 2017. 40. Kim, D.J., Baek, M., Kim, M., Lim, J., Morales, L.D., Tsin, A.T. TC-PTP deficiency in
mouse epidermis promotes UVB-induced keratinocyte cell survival through the regulation of VEGFR2 signaling. Cancer Prevention and Research Institute of Texas Conference, November 2017.
Curriculum Vitae Dae Joon Kim, Ph.D.
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41. Kim, M., Lim, J., Baek, M., Morales, L.D., Jang, I.S., Tsin, A.T., and Kim, D.J. Epidermal- specific deletion of TC-PTP promotes UVB-induced keratinocyte cell survival
through the regulation of VEGFR2/JNK signaling. The 57th Annual Meeting of Society of Toxicology, March 2018.
42. Kim, M., Lim, J., Morales, L.D., Jang, I.S., Tsin, A.T., and Kim, D.J. Epidermal-specific overexpression of T-cell protein tyrosine phosphatase in mouse attenuates
chemically-induced skin carcinogenesis. The 109th Annual Meeting of American Association for Cancer Research, April 2018.
PATENTS
1. Kim, D.J., Kim, M., Jung, J.-Y., Kim, W.J., Slaga, T.J. “GFR1 as a Biomarker for Cisplatin- Induced Chemoresistance and Metastasis.” PCT/US2016/036875.