Cyano-Bridged Coordination Polymer Nanoparticles as High ...
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SUPPLEMENTARY INFORMATION
Cyano-Bridged Coordination Polymer Nanoparticles as High
Relaxivity Contrast Agent for MRI.
Yannick Guari,a Joulia Larionova,a* Maurizio Corti,b,d Alessandro Lasciafari,c,d*
Massimo Marinone,c Giulio Poletti,c Karine Molvinger,e and Christian Guérin.a
aInstitut Charles Gerhardt Montpellier, UMR 5253 CNRS-UM2-ENSCM-UM1, Chimie
Moléculaire et Organisation du Solide, Université Montpellier II, Place E. Bataillon,
34095 Montpellier cedex 5, France. Fax: (33) 4 67 14 38 52, e-mail: joulia@univ-
montp2.fr.
b Dipartimento di Fisica “A. Volta”, Università degli studi di Pavia, Via Bassi 6, I-27100
Pavia, Italy. Fax: (39) 0382 987563, email : [email protected]
c Istituto di Fisiologia Generale e Chimica Biologica, Università degli studi di Milano, I-
20134 Milano, Italy and CNR-INFM-S3 NRC, I-41100 Modena, Italy. Fax: (39) 02 50315775,
email : [email protected]
d INFM-CNR c/o Dipartimento di Fisica “A. Volta”, Università degli studi di Pavia, Via
Bassi 6, I-27100 Pavia, Italy
e Institut Charles Gerhardt Montpellier, UMR 5253, Matériaux Avancés pour la Catalyse et la
Santé, Ecole Nationale Supérieure de Chimie de Montpellier, 8, rue de l’école normale,
34296 Montpellier cedex 5, France.
Electronic Supplementary Information for Dalton TransactionsThis journal is © The Royal Society of Chemistry 2008
H O
H
NH2H
CH2OH
OH O
H O
H
NHCOCH3H
OH
CH2OH
OO
n
Figure 1S. a) Chitosan chemical formula and b) Schematic representation of the intrapore
growth of cyano-bridged coordination polymer nanoparticles Gd3+/[Fe(CN)6]3-/chitosan.
a)
b)
Gd3+
[Fe(CN)6]3-
0
0.05
0.1
0.15
0.2
0.25
0.3
0.35
0
0.05
0.1
0.15
0.2
0.25
0.3
0.35
0.4
0 5 10 15 20 25
χ' /
emu
μL-1 χ'' / em
u μL-1
T / K
0
5 104
1 105
1.5 105
2 105
2.5 105
3 105
0 50 100 150 200 250 300 350
1/χ
wei
ght /
emu-1
Oe-1
g
T / K
Figure 2S. Temperature dependence of the ac susceptibility, its χ’ (in phase) and χ’’, out-of-
phase components at the frequency of 125 Hz showing the paramagnetic behaviour of the
sample. Static field is of 0 Oe and alternative field is of 3 Oe. . b) Temperature dependence of
the inverse of the magnetic susceptibility performed with an applied field of 1000 Oe for the
sample 1.
0 2 4 6 8 100
50
100
150
200
250
Occ
uren
ce/n
Diameter/nm
Figure 3S. a) TEM image and b) size distribution of sample 1. Scale bar = 50 nm.
a)
b)
100
10
20
30
40
50
r 2p (m
M-1s-1
)
ν (MHz)
Figure 4S. Transverse relaxivity of sample 2 ( ), collected at T≈25°C, compared to the same
quantity reported for the commercial compound Omniscan ( ).
Equation 1S :
By definition of relaxivity rip (i=1 refers to longitudinal relaxivity, i=2 to transverse relaxivity): rip = [ (1/Ti)meas – (1/Ti)dia ] / c i=1,2 (1S) where (1/Ti)meas is the measured value on the sample with concentration c (mmol L-1) of magnetic center (8 mmol L-1 in our case), and (1/Ti)dia refers to the nuclear relaxation rate of the diamagnetic host solution (water in our case).