Curriculum Vitae Europass - asst-garda.it · Data Dal maggio 2013 al settembre 2013 Lavoro o...

Curriculum

Vitae Europass

Informazioni personaliTitoli

Italiano: Dott., Dottorando Ph.D.

Internazionale: MD, GP, DCH, Ph.Drs.

Nome

Cognome

Ferenc

Czimbalmos KozmaIndirizzo Residenza: (via e-mail [email protected])

Domicilio: (via e-mail [email protected])Telefono (via e-mail [email protected])

Stato di residenza

Cittadinanza

Italia, dal 2011.

Ungherese, Comunitario UE, HUN UE

Nr. Iscrizione Ordine dei Medici

Iscr. O.M.UD. 5.525/06.03.2013 (http://www.omceoudine.it)Ordine dei Medici, Chirurgi e Odontoiatri della Provincia di UDINE

Codice fiscale (via e-mail [email protected])

Partita IVA (via e-mail [email protected])

Data di nascita Il 15 ottombre 1961

Sesso Maschile

Nazionalità Ungherese

Religione Cattolico romano

Occupazione

Settore professionale

MEDICO SPECIALISTA PEDIATRA, MEDICO GENERICO, MEDICO DI GUARDIA

Medico Specialista Pediatra, Dottorando Ph.D. (farmacologia)

Pagina 1/16 - Curriculum vitae di Dott. Ferenc C. Kozma

Per maggiori informazioni su Europass: http://europass.cedefop.europa.eu© Unione europea, 2002-2010 24082010

http://www.omceoudine.it/doctors/94185

mailto:[email protected]







Esperienza professionale

In Italia

Data Dal 20. 05. 2016

Lavoro o posizione ricoperti Medico Specialista PediatraPrincipali attività e

responsabilità Medico Specialista Pediatra di guardia, P.S. e riparti di Pediatria

Nome e indirizzo del datore di lavoro

A. S. S. T. del Garda, Ospedale di Desenzano del Garda

Tipo di attività o settore Salute, S. S. N.

Data Dal 01. 01. 2016 Lavoro o posizione ricoperti Medico Specialista

Principali attività e responsabilità

Medico Specialista, Medico di guardia, P.S. e reparti di Medicina Interna


Policlinico Universitario Sant'Orsola-MalpighiAlma Mater Studiorum - Università di Bologna

Tipo di attività o settore Salute, Settore Universitario

Data Mese di maggio 2015 Lavoro o posizione ricoperti Medico di guardia di Continuita Assistenziale, medico generico


Medico di guardia di Continuita Assistenziale, Distretto di Faenza.


Azienda USL della Romagna, Dipartimento Cure Primarie – Faenza

Tipo di attività o settore Salute, SSN

Data Dal settembre 2014 al maggio 2015 Lavoro o posizione ricoperti Medico di guardia ospedaliero, medico generico


Medico di guardia ospedaliero, riparto postacuti e riabilitazione.


Ospedale Privato Accreditato Villa Regina, Bologna

Tipo di attività o settore Salute, Settore Privato Accreditato

Data Dal luglio 2014 al settembre 2014Lavoro o posizione ricoperti Medico di guardia turistica, medico generico


Medico di guardia turistica, Rimini.


Azienda USL della Romagna, Dipartimento Cure Primarie – Rimini




Data Dal maggio 2013 al settembre 2013Lavoro o posizione ricoperti Medico di guardia turistica, medico generico


Medico di guardia turistica, Ravenna.


Azienda USL della Romagna, Dipartimento Cure Primarie – Faenza


ALL ESTERO (UE)

Data Dal 2009 in Ungheria, UE Lavoro o posizione ricoperti Dottorando di ricerca in farmacologia oncologica


Medico specialista, ricercatore dottorando di farmacologia oncologica


PTE AOK Università di PÉCS, Scuola Dottorale, Programa “O5”, Ungheriahttp://english.pte.hu ; http://doktoriiskola.etk.pte.hu

Tipo di attività o settore Salute, Studi postgaduali di dottorato di ricerca medicaSvolti tutti i tre anni di corsi.

Data Dal 1990 al 2011 in Ungheria, UE (continuo, con aggiornamento professionale conforme U.E., con partecipazione alla guardia)

Lavoro o posizione ricoperti Medico specialista pediatra e medico di guardia (dal 1993), (medico generico dal 1990 al 1993), dottorando di ricerca in farmacologia oncologica (dal 2009)


Medico specialista pediatra di base libera professionista e dottorando di ricerca


Medico di base libera professionista privata, e dottorando di ricerca Ungheria

Data Dal 2009 al 2011 in Ungheria, UELavoro o posizione ricoperti Medico specialista pediatra ospedaliero


Medico specialista pediatra in dipartimento di pronto soccorso ospedaliero, ostetricia e poliambulatorio


Ospedale Civile Mohács, piazza Szepessy 7, 7700 Mohacs, Ungheria.

Data Dal 1988 al 1990 in Romania, UE Lavoro o posizione ricoperti Medico generico


Medico generico


Tipo di attività o settore

Periodo di tirocinio postuniversitario in vari strutture ospedaliere e di territorio.

Salute, Settore dello Stato



http://doktoriiskola.etk.pte.hu/



http://english.pte.hu/



Istruzione e formazione

Data Dal 01. 09. 2009 -Titolo della qualifica rilasciata Dottorando PhD

Principali tematiche/competenze professionali acquisite

Formazione in corso. Dottorando PhD e ricercatore oncologo.

Nome e tipo d'organizzazione erogatrice dell'istruzione e

formazione

Scuola Dottorale della Università degli Studi di Pécs – PTE - ETK Ungheria

Livello nella classificazione nazionale o internazionale

ISCED 8. (Dottorato in corso, tutti i crediti acquisti)

Data 1985-1987 e 01. 04. 1990 – 03. 12. 1993Titolo della qualifica rilasciata Medico specialista pediatra (con aggiornamento professionale conforme U. E.)

Principali tematiche/competenze professionali acquisite

Medico specialista pediatra e neonatologo. Epidemiologia, fisiopatologia, diagnostica, prevenzione, terapia e cura delle malattie d'infanzia, ecc. Formazione complessa, specialistica, postuniversitaria, teoretica e pratica di 5 anni.


formazione

Università di Medicina e Farmacia di Tîrgu Mures, Romania, 1985-1987 eUniversità Semmelweis, Budapest, Ungheria, 1990-1993 (studi finiti in Ungheria, dopo trasloco). Laurea specialistica a Budapest, il 02/12/1993.


ISCED 7.2 (Medico specialista pediatra).

Data 1981 - 1987Titolo della qualifica rilasciata Laurea in medicina (con aggiornamento professionale conforme U. E.)

Principali tematiche/competenze

professionali acquisite

Medico. Studi universitari di medicina, programma conforme U.E. (Anatomia, fisiologia, biochimica, genetica, patologia, sintomatologia, ecc. Farmacologia, ecc. e le specialità in medicina.Epidemiologia, fisiopatologia, diagnostica, prevenzione, terapia e cura delle malattie, ecc.). Formazione universitaria, complessa, teoretica e pratica di 6 anni.


formazione

Università di Medicina e Farmacia di Tîrgu Mures, Romania,


ISCED 7.1 (Medico, laurea in medicina, formazione universitaria di 6 anni).

Riconoscimento dei titoli in Italia

Titolo Medico Chirurgo 24/01/2013, DECRETO del Ministero della Salute 24/01/2013http://www.trovanorme.salute.gov.it

Titolo Medico Specialista Pediatra DECRETO del Ministero della Salute 12/04/2013 http://www.trovanorme.salute.gov.it



http://www.trovanorme.salute.gov.it/norme/renderTrpPdf;jsessionid=S5nkELBpavfU



http://www.trovanorme.salute.gov.it/norme/renderTrpPdf?codleg=45091&anno=2013&parte=1



Altre tematiche/competenze professionali acquisite

Scuola tecnica di laboratorio chimia e biologiaStudi universitari di elettronica medica.Studi di informatica (hardware, sistemi operazionali)Abilità di presentare studi specialistici in pubblico, in congressi, in inglese, italiano, francese, rumeno, ungherese.Esperienza medica dal 1988 (pediatria, pronto soccorso)Lavoro di ricerca oncologica in laboratorio, spettroscopia, cromatografia, microscopia in vivo, sperimenti sulle linee cellulere maligne e animali di sperimento.

Altre lingueAutovalutazione livello

europeo (*) Comprensione Parlato Scritto

Ascolto Lettura Interazione orale Produzione orale

Lingua C1 Italiana C1 Italiana B2 Italiana B2 Italiana B2 Italiana

Lingua B1 inglese B1 inglese B1 inglese B2 inglese B1 inglese

Lingua A2 francese B2 francese B1 francese B2 francese B1 francese

Lingua A1 tedesca A1 tedesca A1 tedesca A1 tedesca A1 tedesca

Lingua A1 russa A1 russa A1 russa A1 russa A1 russa

Lingua(**) C2 romena C2 romena C2 romena C2 romena C2 romena

Lingua(**) C2 ungherese C2 ungherese C2 ungherese C2 ungherese C2 ungherese(*) Quadro comune europeo di riferimento per le lingue

Capacità e competenze sociali

Capacità di adeguamento ad ambienti multiculturali;Buono spirito di gruppo; Buone capacità di comunicazione;Ho partecipato alla fondazione del movimento cattolico clandestino, nella città dove ho studiato all'università, prima della rivoluzione anticommunista in Romania (abitavo là);Come attività volontaria, aiutavo gli anziani;Ho partecipato agli esercizi spirituali cattolici.

Capacità e competenze organizzative

Capacità di organizzare il lavoro in territorio, guardia medica, dipertimento ospedaliero e ambulatorio;Buona attitudine alla gestione di progetti e di gruppi, p.es. team di ricerca;Organizzare i viaggi in centri culturali e musei d'Europa;Organizzare i grandi avvenimenti familiari.

Capacità e competenze tecniche

Uso dell'apparecchiatura medica di emergenza e terapia intensiva.Uso dell'apparecchatura di ricerca in laboratorio di ricerca oncologica.Uso dell'apparecchatura cromatografica e spettroscopica.Competenze militare (servizio obbligatorio) di commando, uso dell'armamento e tecnica speciale e degli esplosivi, artigliere da cecchino, competenze con l'armi con telescopio.



http://europass.cedefop.europa.eu/LanguageSelfAssessmentGrid/it



Capacità e competenze informatiche

Conoscenze al livello di utente dei sistemi operazionali Unix (Linux, Symbian, Android) e Windows, Conoscenze al livello di utente dei programmi SUN Microsystems Open Office e Microsoft Office (Word, Excel, Power Point), Redigere documenti (odt., doc., xls., pdf., ppt., pps.,), redigere siti web Conoscenze al livello di hardware il computer, cambiare, installare hardware. Conoscenze al livello di utente delle varie apparecchiature mediche computerizzate.

Capacità e competenze artistiche

Grafica (illustratore di corsi universitari)Cucinare specialità gastronomiche italiani e ungheresi.Fotografare la natura, gli animali, il mare, i ritratti.

Altre capacità e competenze

Passatempi:Elettronica hobby. Astronomia. Matematica.Produzione dei vini rossi (medaglia d'oro categoria Merlot, mostra nazionale ungherese 2008),Alpinismo, incluso vulcani attivi,Turismo culturale, visitare i famosi musei e città storiche d'Europa,Storia delle arte,Opera, teatro, musica (classica, Dixieland, anni '60 italiani, moderna),Cultura e letteratura classica, tecnica e scientifica.Cultura tecnica e scientifica (fortezze, volo, storia, nautica, tecnica spaziale, astronomia).

Patente “B” dal 1988, Patente italiano valido.

Ulterioriinformazioni

** Lingua romena e unherese: certificato di stato di traduttore di specialità medica.Riferimenti: da vedere l'allegato.

Allegati Elenco delle pubblicazioni, congressi internazionali, brevetti, copyright, raccomandazioni, documenti.

Firma



Allegati:

Ultimi congressi internazionali (oncologia):

1.

Ferenc Czimbalmos-Kozma 1, Erika Papp 1,Róbert Ohmacht 4, Ferenc Budán 1,Tímea Varjas 1, Éva Szőke 2, Éva Jámbor 4,János Jung 3 (Chairman), István Ember 1(Chairman)

1 Department of Public Health, Faculty of Health Sciences, Medical School, University of Pécs, H-7643 Pécs, Hungary2 Department of Pharmacology, Faculty of Health Sciences, Medical School, University of Pécs, H-7643 Pécs, Hungary3 Department of Pathology, Faculty of Medicine, University of Medicine and Pharmacy Târgu Mureş, România4 Department of Biochemistry and Medical Chemistry, Faculty of Health Sciences, Medical School, University of Pécs, Hungary

“The inhibitory effect of the sweet chestnut extracts on the tumor cell cultures (The antimitochondrial target in oncopharmacology)”

INTERNATIONAL CONFERENCE OF PREVENTIVE MEDICINE AND PUBLIC HEALTH19-20 NOVEMBER 2010 PÉCS, HUNGARY

Institute of Public Health, Medical School, University of PécsHungarian Society for EpidemiologyWorking Committee for Preventive Medicine, PécsCommittee of the Hungarian National AcademySouth-Transdanubian Regional Public Health Center

2.

Czimbalmos-Kozma Ferenc, Papp Erika

“The inhibitory effect of the sweet chestnut extracts on the tumor cell cultures”

International Medical Congress, Targu Mures, 23-25. 05. 2009.Medical And Pharmaceutical University of Targu Mures, Romania, Medical and Pharmaceutical Section of the Society of the Transylvanian MuseumAcademy of Science Of Republic of Hungary

Abstract

Life should be logical. Because life is a part of the Universe, and “the mathematicsof the Universe should be beautiful” (Garrrett Lisi),the life should have a beautifulmathematics too, and, naturally, all the processes of the life should be logic. Lifeprocesses lacking reason simply does not exist. The processes of life must be logicand mathematically modellable. But here we encounter problems: the malignanttissues have new, special, complex functions, useful for themselves only – from theloss of function and wrong mechanisms cannot arise special, developed, targetedfunctions having the capacity of adaptation. And the resultant malignant tissuesmake something exactly contrary to the interests of the organism: apparently theorganism poses a non-logical program and operates with a loss of reason. But thisis not probable. This study examines the mathematical considerations of thepossible mitochondrial (exactly: the mutantmitochondrial) aetiology of themalignancy, in part based on finding the logically possible and not possible modelsof the cells, as systems, in the structural concept of the Turing-machines, in partbased on the logically possible information pathways in the cell division, etc. Thestudy the authors’ original theories as to mathematical modelling of malignantprocesses, describing the algorithms of the possible actions of the mutantmitochondria(arising from endosymbionts to intracellular parasites) in the processof the malignization; in short, it presents some preliminary results from the authors’original experimental lab works with possible antimitochondrial agents, like thesweet chestnut plant extracts (elected thanks to the results of mathematicalmodelling) under malignant cell culture lines.

Keywords: malignancy, modelling, mitochondriaPagina 7/16 - Curriculum vitae di

Dott. Ferenc C. KozmaPer maggiori informazioni su Europass: http://europass.cedefop.europa.eu© Unione europea, 2002-2010 24082010

Pubblicazioni:

1. CELIAC DISEASE

In the years '90 the author described a new method of laboratory diagnosis for glutenesensitive enteropathy, published in the Hungarian Pediatrician and presented onthe National Congress of Pediatrics in Balatonaliga, Hungary, on the 24-26 may2001.

„New ELISA diagnostics of the GSE”

Dr. Czimbalmos-Kozma Ferenc

ABSTRACT:

Nowadays, gastroenterological diseases are coming into prominence,because recent epidemic data have shown unexpected, increasing incidence ofthem. Despite both the trigger food and the autoimmune pathomechanism of thediseases are well known (e .g. in celiac disease) it seems reasonable to makefurther efforts to identify the large number of potentially immunogenic alimentarycomponents. A portion of these components is insoluble in water, therefore, theyare difficult to analyse. In this paper a new method is published that, according topreliminary results, seems to be useful in immunological testing of the alimentarycomponents soluble only in organic solvents. The method is suitable for obtaininghighly purified separated fractions even in such an amount that immunological kitsmight be produced of them. The method is demonstrated on the example of wheatand (in part) oat, both playing major ethiological role in celiac disease. Thispreliminary communication presents an outlined description of the extraction ofwheat flour with organic solvents and publishes some spectrophotometric results. Aprocedure for the preparation of a solution suitable to be subjected anelectrophoretic separation of the organic extract is reported. Furthermore, a non - HPLC chromatographic method is described in which an organic eluent is used forvery effective separation of the non-polar components of corn on larger scale. Themethod may be adapted in botany and agriculture for identification of species. Thedifference between the chromatograms of wheat and oat extracts is also presented.A modified ELISA procedure has been developed to investigate the separatedfractions. Though based on a relatively few samples analysed, the preliminaryresults show that there is a c on siderable difference in the reactivity between theserum of the healthy and that of the ill patients. The serum of the celiacal patientsalso exhibit remarkable differences and this may be informative for the family doctorwhether the patient has kept to his/her diet. It can be seen, that the serum of theceliacal patient reacts with more than one component of the extract. Thechromatographic investigations showed, that there is a difference in thecomposition of the wheat and oat extracts. There is a com po nent present in thewheat extract but absent from that of oat. It should be emphasised that the presentpaper is only a preliminary communication. Our goal is to report the methodsdeveloped in a hope that application of them would help and initiate furtherinvestigations on diagnostics of corn-antigeninduced diseases. Our methods alsomay facilitate the creation of a follow-up monitoring system to evaluate the purity,identity and potential immunogenic properties of corn and oil-seed from differenthabi ta ts and vegetation periods, and even enable the laboratory testing tosubstitute the duodenal biopsy. The current, widely used methods involveenzymatichydrolysis of the water-insoluble alimentary components prior toseparation. As a result, a large numbe r of fractions is obtained and there is a littleor no information about the composition of the original food. To avoid the abovedifficulties it is proposed to apply the separation by the presented method prior tothe enzymatic hydrolysis for the sake of better recognition of theimmunomechanism.

KEYWORDS: gastroenterological diseases, celiac disease, fractions of the gluten,gliadin, cromatography, electrophoresis, ELISA, autoimmunity.



2. SUDDEN INFANT DYING SYNDROME, SIDS

In the years '90 the author described the first case of SIDS in Hungary, with foundedneurohistopathological diagnosis, in collaboration with Prof. Dr. Luigi Matturri fromthe University of Milan, Italy, published in the Hungarian Pediatrics Newsletter ofthe National Congress of Pediatrics in Balatonaliga, Hungary, May 2002, andpresented on the National Congress of Pediatrics in in Balatonaliga, Hungary, onthe 24-26 May 2002, and in the 1.th Channel of the Hungarian State Television, onthe 22 March 2002.

„SIDS and the hypoplasia of the nucleus arcuatus”

Dr. Czimbalmos-Kozma Ferenc

in collaboration with Prof. Dr. Luigi Matturri, from the University of Milan, Italy

ABSTRACT:

There are several hypotheses in regard to the etiology of SIDSpathogenesis. The team headed by professor Luigi Matturri of Milan, Italy, focuseson defective embryo-stage development of truncus cerebri and medulla oblongataneuronal structures. It is presumed that the hypoplasias of the reticular formationand especially of the nucleus arcuatus are a risk factor in SIDS. In the author’scase, the patient’s death occurred at the age of 3 months. Heredocollateralanamnesis was positive, as the patient’s brother, now 3 years old, has been 3 timesresuscitated due to apnea episodes during his first year of life, thanks to the apneaalarm employed because of the positive results rendered by the poligraphycexamination during sleep. Furthermore, the patient’s anamnesis pointed out thatthe mother’s smoking during pregnancy significantly heightened the risk of SIDS.The patient’s neuro-histopathological examination was performed at the PathologyInstitute of the University of Milan by professor Matturri and provided evidenceregarding a serious unilateral hypoplasia of the nucleus arcuatus. The resultsconstitute additional proof for the hypotheses of the Milan-based team. The articlestrongly supports the idea of international cooperation in SIDS research in order toclarify the cause. However, significant steps have recently been made from totalobscurity to concrete hypotheses. Although today it is deemed that SIDS hasseveral causes, abovementioned hypothesis is one of the most important. Theauthor’s case constitutes additional support to extend poligraphyc examinationsduring sleep to patients exposed to higher risks (SIDS in the family, apneaepisodes, and maternal smoking). Furthermore, the article draws attention to theneed of social initiative against SIDS such as the one performed in Italy, whichmanaged to integrate civil and professional organizations, thus reporting excellentresults in the diminishment of SIDS cases.

Keywords: sudden infant death syndrome, neurohistopathology, arcuatenucleus,hypothalamus, apoptosis, thymus, gliosis, reticular formation, cerebellarcortex, dentate gyrus, respiratory center.



3. MATHEMATICS, BIOMATHEMATICS

The author began self-teaching myself mathematics in 1995, and continued with the study ofthe NKS. I published a theoretical study about one possible type of discrete,"quantum" mathematics in 2002 In 2004 I published a possible discrete, "quantum","cell automaton like" dynamic model of the real physical space. Since 2000 I beganto study some algorithm-based models, like Turing machines, and the game theory.Whilst trying to model the living cell as a dynamic system, described by algorithms,I wrote the Turing machine-based model of the living cell and the model ofinformation flow in normal and cancer cells, based on the concept of cell modellinglike non-virtual Turing machines.

„The Theory of the Discrete Field”©

ABSTRACT:

The Basic Concept of the Discrete Field © (©Dr. Czimbalmos-KozmaFerenc, 2004) The goal of the Discrete Field Theory is to describe all the structuresand phenomena belonging to the real physical Universe on the grounds of unitaryand general principles. The discrete field theory assumes that the space of theUniverse is not empty, it’s not “made out of nothing,” it is not a mathematic, abstractspace; rather, it is a space constituted of an actual material field, which definitelyisn’t a mere a mathematical abstraction. The field is built up by the total sum of itssub-units, hereinafter called “toposes,” whose number is unimaginable, yet finite.Thus, the field’s subunits, i.e. the toposes, are individual and discrete, and have theminimum possible size and dimension in all space directions (yet said size is notnil). Moreover, toposes are indivisible and lack structure. Space constitutingtoposes are contiguous and interact. The discrete field theory assumes that spaceand time are identical and the ultrastructure of the field constituting the Universe’sspace is not continuous; rather, it is nonhomogenous and anisotropic at the lowestpossible scale of size and dimension (the real, existing physical space has a“granular” texture). The discrete field theory assumes that toposes constitutingspace may exist in two different states: basic state and transformedstate. The set ofneighboring toposes in a basicstate build up what is called the void. Globaltopological models describing the topology of toposes’ vicinities on the set of alltoposes may have solutions (spherical models, Moebius bands, etc.) that leave outtoposes without neighbors in a dimension, and thus constitute infinite cosmologicalmodels, while those accepting such toposes constitute finite cosmological models.The special topological models describing field texture and various topologicalmodels of toposes’ distribution symmetry in the field (spherical, hexagonal, spiral,cubical, helicoidal symmetries, etc.) are describing spaces that are Euclidean,hyperbolic, etc, or special situations (space curvatures, singularities, etc.) on thegrounds of general and unitary principles. A topos shifts from the basic state into atransformed state because of the transformation of neighboring toposes, within theshortest possible time, which however isn’t equal to zero. Such duration shallhereinafter be called basic time. The transformed topos shall maintain said statethroughout the duration of a basic time, and shall return to the basic state within thefollowing basic time sequence. The shift from basic state into transformed conditionisn’t continuous; instead, it is quantum-like. Basic time of all neighboring toposesissynchronous. The topos shifts from the basic state into a transformed state as aconsequence of the transformation of neighboring toposes. Thus, the set of alltoposes constitute an orderly topological set of points, which, within the sequentialsuccession of basic times, makes up a cell automaton. © Copyright 2002-2004 Dr.Czimbalmos-Kozma Ferenc. (BIOMATHEMATICS: see 4.)



4. ONCOLOGY

ABSTRACT OF THE ARTICLE INCLUDING THE MITOCHONDRIAL THEORY OFCANCER,

presented on the International Medical Congress in Targu Mures, organised by theMedical And Pharmaceutical University of Targu Mures, Romania, the Medical andPharmaceutical Section of the the Transylvanian Museum Society and theAcademy of Science Of Republic of Hungary in May 2009, and on theINTERNATIONAL CONFERENCE OF PREVENTIVE MEDICINE ANDPUBLIC HEALTH, 19-20 NOVEMBER 2010 PÉCS, HUNGARY.(article published in the Bulletin of Medical Sciences of theTRANSYLVANIAN MUSEUM SOCIETY).

“The inhibitory effect of the sweet chestnut extracts on the tumor cell cultures”

Czimbalmos-Kozma Ferenc, Papp Erika

ABSTRACT:

Life should be logical. Because life is a part of the Universe, and “the mathematicsof the Universe should be beautiful” (Garrrett Lisi), the life should have a beautifulmathematics too, and, naturally, all the processes of the life should be logic. Lifeprocesses lacking reason simply does not exist. The processes of life must be logicand mathematically modellable. But here we encounter problems: the malignanttissues have new, special, complex functions, useful for themselves only – from theloss of function and wrong mechanisms cannot arise special, developed, targetedfunctions having the capacity of adaptation. And the resultant malignant tissuesmake something exactly contrary to the interests of the organism: apparently theorganism poses a non-logical program and operates with a loss of reason. But thisis not probable. This study examines the mathematical considerations of thepossible mitochondrial (exactly: the mutantmitochondrial) aetiology of themalignancy, in part based on finding the logically possible and not possible modelsof the cells, as systems, in the structural concept of the Turing-machines, in partbased on the logically possible information pathways in the cell division, etc. Thestudy the authors’ original theories as to mathematical modelling of malignantprocesses, describing the algorithms of the possible actions of themutantmitochondria (arising from endosymbionts to intracellular parasites) in the processof the malignization; in short, it presents some preliminary results from the authors’original experimental lab works with possible antimitochondrial agents, like thesweet chestnut plant extracts (elected thanks to the results of mathematicalmodelling) under malignant cell culture lines.

Keywords: malignancy, modelling, mitochondria



BREVETTI, © COPYRIGHT:

“The use of the extracts and the drug forms (infusions, solutions, injections, tabletsand other drug forms) obtained from Castanea sativa (and subsp.) or obtainedfrom the components of the extracts extracts of the Castanea sativa (and subsp.) inthe in vitro inhibition of the malignant cell line cultures and in the preparation of thedrugs used for the treatment of malignant tumours.”PATENT FOR USE OF CASTANEA SATIVA AND COMP. IN THE RESEARCHAND THERAPY OF MALIGNANT TUMORS, PAT. No P0800453.,REG. No 0816705., REG. DATE: 07. 22. 2008., HUNGARIAN PATENT OFFICE, BUDAPEST, HUNGARY, EU. BY Dr. CZIMBALMOS-KOZMA, FERENC, Dr. PAPP, ERIKA.

"THE MITOCHONDRIAL THEORY OF CANCER", © ARTISJUS COPYRIGHT No 080722001T, DATE: 07. 22. 2008. BY Dr. CZIMBALMOS-KOZMA, FERENC, Dr. PAPP, ERIKA.COPYRIGHT © REG. BY THE HUNGARIAN ARTISJUS OFFICE ASSOCIATIONFOR COPYRIGHT PROTECTION.



Article review:

Request to Review Cancer Research Manuscript: CAN-09-1709

[email protected]<[email protected]>

2009. május 15. 12:57

Címzett: [email protected]

Dear Ms. Dr. Czimbalmos-Kozma:

We request your assistance as a reviewer for the above-referenced submission to the AACR journal CANCER RESEARCH.

The name of the assigned editor, title, corresponding author, and abstract are listed below for your reference. If you agree to review this manuscript, when making your recommendation concerning acceptability please remember that due the journal's stringent publication requirements, manuscripts that receive a priority score of less than 2 will not be accepted for publication. If you agree to review this manuscript, you would be given two weeks to complete your review.

EDITORSofia Merajver

MANUSCRIPT NUMBER CAN-09-1709

MANUSCRIPT TITLEDetection of Treatment-Induced Changes in Signaling Pathways in Gastrointestinal Stromal Tumors using Transcriptomic Data

MANUSCRIPT TYPE Research Article

AUTHOR Dr. Ochs

ABSTRACTCell signaling plays a central role in the etiology of cancer. Numerous therapeutics in use or under development target signaling proteins, however off-target effects often limit assignment of positive clinical response to the intended target. As direct measurements of signaling protein activity are not generally feasible during treatment, there is a need for more powerful methods to determine if therapeutics inhibit their targets and when off-target effects occur.We have used the Bayesian Decomposition algorithm and data on transcriptional regulation to create a novel methodology, DESIDE (Differential Expression for SIgnaling DEtermination), for inferring signaling activity from microarray measurements. We applied DESIDE to deduce signaling activity in gastrointestinal stromal tumor cell lines treated with the targeted therapeutic imatinib mesylate (Gleevec). We detected the expected reduced activity in the KIT pathway, as well as unexpected changes in the TP53 pathway.Pursuing these findings, we have determined that imatinib-induced DNA damage is responsible for the increased activity of TP53, identifying a novel off-target activity for this drug. We then used DESIDE on data from resected, post-imatinib treatment tumor samples and identified a pattern in these tumors similar to that at late time points in the cell lines, and this pattern correlated with initial tumor response. The pattern showed increased activity of ELK1 and STAT3 transcription factors, which are associated with the growth of side population cells.DESIDE infers the global reprogramming of signaling networks during treatment, permitting treatment modification that leverages ongoing drug development efforts, which is crucial for personalized medicine.

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