Appartengono al gruppo dei polifenoliMigliaia di molecole

FLAVONOIDI

FLAVONOIDI

CAROTENOIDI E RISCHIO CV

STUDI EPIDEMIOLOGICIRapporti tra introiti alimentari e

CVD

Effetto protettivo

> 600 molecol

e

α-carotene, β-carotene, licopene, luteina, zeaxantina.....

TRIALS CLINICISupplementazione

mortalità in alcuni trials

Kristenson M et al. BMJ 1997 Rapola JM et al, Lancet 1997 Osganian SK et al Am J Clin Nutr 2003 Hak AE et al. Circulation 2003 Knekt P et al. Am J Clin Nutr 2004 Sesso HD et al. Am J Clin Nutr 2005 Tavani A et al. Free Radic Res 2006 Ito Y et al. J Epidemiol 2006

Vivekananthan DP et al. Lancet 2003 Bjelakovi G et al. JAMA 2007

ANTIOXIDANT SUPPLEMENTS Cochrane Database Systematic Review 2012

AUTHORS’ CONCLUSIONS

We found no evidence to support antioxidant supplements for primary or secondary prevention. Beta-carotene and vitamin E seem to increase mortality, and so may higher doses of vitamin A.

There is not currently sufficient conclusive evidence to justify making any public health recommendation in relation to antioxidants

ANTIOXIDANTS

ANTIOXIDANTS

ZUCCHERI AGGIUNTI: RACCOMANDAZIONI

BEVANDE DOLCI: RACCOMANDAZIONI

BEVANDE DOLCI E RISCHIO CARDIOMETABOLICO

Consumption of sugar-sweetened beverages has been associated to:

• non-alcoholic fatty liver disease

• hypertricerydemia

• increased visceral fat

• obesity

• metabolic syndrome

• cardiovascular disease

Richelsen B et al. Sugar-sweetened beverages and cardio-metabolic disease risk

Curr Opin Clin Nutr Matab Care 2013 (in press)

Nutrition 2010; 26: 1044-9

World Action on Salt & Health(WASH)

SALE: RACCOMANDAZIONI

Intermediate target < 5 g/die

SALTSALT

Long-term GOAL < 4 g/die

Greater adherence to a Mediterranean diet confers a significant protection for overall mortality, as well as cardiovascular disease mortality and incidence of cancer and degenerative diseases.

MODELLO ALIMENTARE MEDITERRANEO

BMJ 2008; 337:a1344

BMJ 2008; 337:a1344

Am J Clin Nutr 2010; 92: 1180-96

Kastorini CM, J Am Coll Cardiol 2011; 57: 1299-1313

35 studi534.906 soggetti

Efficace in prevenzione primaria

S. metabolica DIETA MEDITERRANEAS. metabolica DIETA MEDITERRANEA

Kastorini CM, J Am Coll Cardiol 2011; 57: 1299-1313

Migliora i parametri metabolici

S. metabolica DIETA MEDITERRANEAS. metabolica DIETA MEDITERRANEA

DIETE MEDITERRANEE: CARATTERISTICHE

ALIMENTAZIONE E PREVENZIONE CARDIOVASCOLARE

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